Automatic radiopharmaceutical detection equipment

Abstract

The utility model provides automatic radiopharmaceutical detection equipment, which comprises a working table and a protective shell arranged on the outer side of the working table, an activity detection mechanism and / or an endotoxin detection module and / or a nuclide detection module and / or a PH detection platform are sequentially arranged on the working table, and a medicine carrying mechanism is further arranged on the working table. The medicine carrying mechanism comprises a movably arranged sample platform and a medicine placing position arranged on one side of the sample platform, so that after medicine bottles to be detected are placed on the medicine placing position, the medicines are sequentially sampled into all reagent bottles on the sample platform to be detected; according to the utility model, the safety of radiopharmaceutical detection is improved, and various types of detection can be synchronously carried out in a single pharmaceutical detection process.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical testing equipment, and in particular to an automatic testing device for radioactive pharmaceuticals. Background Technology

[0002] In the field of radiopharmaceutical testing, manual intervention is required, resulting in low efficiency and extended testing time. Although the relevant shielding and protection measures have a high shielding effect, they still pose a certain degree of radiation damage to operators, and safety cannot be guaranteed. At the same time, the quality control of radiopharmaceutical testing has been a field where automation has progressed relatively slowly. Only in recent years have some integrated positron emission tomography (PET) quality control devices been developed.

[0003] However, the existing instruments and equipment have different testing functions and are not fully suitable for the needs of nuclear medicine companies. Because these companies test a variety of drugs, they are not limited to testing positron-emitting drugs, but often need to test other types of radiopharmaceuticals and drug intermediates. Secondly, the testing methods of some imported equipment may not meet the requirements of relevant domestic regulatory authorities, and the testing process lacks flexibility. At the same time, these devices still require manual sample introduction and manual waste disposal, which involve contact with radiopharmaceuticals and cannot completely avoid radiation exposure. Utility Model Content

[0004] The purpose of this invention is to provide an automatic radiopharmaceutical detection device that improves the safety of radiopharmaceutical detection and ensures that multiple types of detections can be performed simultaneously during a single drug detection process.

[0005] To solve the above-mentioned technical problems, this utility model provides an automatic detection device for radiopharmaceuticals, including a workbench and a protective shell disposed outside the workbench. The workbench is sequentially provided with an activity detection mechanism and / or an endotoxin detection module and / or a radionuclide detection module and / or a pH detection platform. The workbench also has a drug transport mechanism, which includes a movable sample platform and a drug placement position disposed on one side of the sample platform, so that after the drug bottle to be tested is placed in the drug placement position, the drug is sequentially sampled to each reagent bottle at the sample platform for testing.

[0006] Furthermore, a robotic arm extends inward from the protective shell, and a liquid extraction and injection mechanism is also provided on the worktable. The liquid extraction and injection mechanism includes a syringe connecting plate for placing a syringe, a first lifting rail located on one side of the syringe connecting plate, and a second lifting rail connected to the syringe handle, so that the syringe can sample or inject from the medicine bottle.

[0007] Furthermore, the medicine placement position is rotatable, so that when the syringe takes a sample from the medicine bottle, the medicine placement position causes the medicine bottle to rotate and tilt.

[0008] Furthermore, a medicine bottle opening mechanism is also provided on the workbench. The medicine bottle opening mechanism includes a positioning platform on one side of the sample platform and an inclined surface on the side of the positioning platform close to the sample platform. The inclined surface matches the cap of the medicine bottle so that when the medicine bottle passes the positioning platform, the cap of the medicine bottle is opened along the inclined surface.

[0009] Furthermore, the workbench is also equipped with a reagent bottle opening mechanism, which includes a horizontally movable opening slide, a lifting opening slide on one side of the horizontal opening slide, and an opening gripper on one side of the lifting opening slide, so that after the opening gripper grabs the cap of the reagent bottle, it drives the cap of the reagent bottle to rotate and rise to open the cap; the sample platform has a reagent bottle gripper so that when the reagent bottle is opened, the reagent bottle gripper holds the bottom of the reagent bottle.

[0010] Furthermore, a pipetting mechanism is also provided on the worktable, which includes a three-axis moving slide and a pipette located on one side of the three-axis moving slide, so that the pipette can pipe liquid between reagent bottles and between reagent bottles and detection positions.

[0011] Furthermore, a camera is also provided on one side of the three-axis moving slide.

[0012] Furthermore, the activity detection mechanism includes a lifting platform with a lifting mechanism, a placement slot on the lifting platform, and an activity detector located below the lifting platform, so that after the medicine is placed in the placement slot, the lifting platform drives the medicine down to the activity detector for activity detection.

[0013] Furthermore, the top of the sample platform has several cap placement positions, and the cap placement positions correspond to the caps of the reagent bottles.

[0014] Furthermore, positioning blocks are symmetrically arranged on the side of the syringe connecting plate, the syringe is engaged between the two positioning blocks, and the side of the positioning block near the syringe has a spring ball.

[0015] The beneficial effects of this utility model are as follows: the protective shell protects the radioactive drug detection process, preventing radiation damage to the testing personnel. After placing the aluminum can containing the drug to be tested in the designated position on the workbench, a robotic arm opens the can and removes the drug. The drug is then placed at the activity detection mechanism and the drug handling mechanism. The activity detection mechanism performs activity detection, and the drug handling mechanism selectively transfers the drug to the endotoxin detection module, the radionuclide detection module, and the pH detection platform. This allows multiple types of drug detection operations to be performed simultaneously in a single drug testing process. Attached Figure Description

[0016] Figure 1This is a schematic diagram of the structure of this utility model.

[0017] Figure 2 This is a schematic diagram of the internal structure of this utility model.

[0018] Figure 3 This is a schematic diagram of the activity detection mechanism in this utility model.

[0019] Figure 4 This is a schematic diagram of the sample platform in this utility model.

[0020] Figure 5 This is a schematic diagram of the structure of the medicine bottle opening mechanism in this utility model.

[0021] Figure 6 This is a utility model Figure 5 A magnified view of a portion of point A in the middle.

[0022] Figure 7 This is a schematic diagram of the reagent bottle opening mechanism in this utility model.

[0023] Figure 8 This is a schematic diagram of the syringe installation in this utility model.

[0024] Figure 9 This is a utility model Figure 8 A magnified view of a section at point B.

[0025] Figure 10 This is a schematic diagram of the pipetting mechanism in this utility model.

[0026] Reference numerals: 1. Workbench; 2. Protective housing; 3. Robotic arm; 4. Activity detection mechanism; 5. Endotoxin detection module; 6. Radionuclide detection module; 7. pH detection platform; 8. Sample platform; 9. Drug placement position; 10. Drug bottle; 11. Reagent bottle; 12. Syringe; 13. Syringe connecting plate; 14. First lifting rail; 15. Second lifting rail; 16. Positioning stage; 17. Inclined surface; 18. Horizontal cap opening slide; 19. Lifting cap opening slide; 20. Cap opening gripper; 21. Reagent bottle gripper; 22. Three-axis moving slide; 23. Pipette; 24. Camera; 25. Lifting platform; 26. Placement slot; 27. Activity detector; 28. Cap placement position; 29. ​​Positioning block; 30. Spring ball. Detailed Implementation

[0027] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present utility model are within the protection scope of the present utility model.

[0028] Those skilled in the art should understand that, in the disclosure of this utility model, the terms "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, the above terms should not be construed as limitations on this utility model.

[0029] It is understood that the term "a" should be understood as "at least one" or "one or more", that is, in one embodiment, the number of an element can be one, while in another embodiment, the number of the element can be multiple, and the term "a" should not be understood as a limitation on the number.

[0030] like Figures 1-10 The present invention provides an automatic detection device for radioactive drugs, including a workbench 1, a protective shell 2 located outside the workbench 1, and a robotic arm 3 located on the protective shell 2 and extending inward. The workbench 1 is sequentially provided with an activity detection mechanism 4 and / or an endotoxin detection module 5 and / or a radionuclide detection module 6 and / or a pH detection platform 7. The workbench 1 also has a drug transport mechanism, which includes a movable sample platform 8 and a drug placement position 9 located on one side of the sample platform 8, so that after the drug bottle 10 to be tested is placed in the drug placement position 9, the drug is sequentially sampled to each reagent bottle 11 at the sample platform 8 for testing.

[0031] The radiopharmaceutical testing process is protected by a protective shell to prevent radiation damage to testing personnel. After the aluminum can containing the drug to be tested is placed in the designated position on the workbench, a robotic arm opens the can and removes the drug. The drug is then placed at the activity detection mechanism and the drug handling mechanism. The activity detection mechanism performs activity testing, and the drug handling mechanism selectively transfers the drug to the endotoxin detection module, the radionuclide detection module, and the pH detection platform. This allows multiple types of drug testing operations to be performed simultaneously in a single drug testing process.

[0032] The protective shell is made of aluminum shielding and has an aluminum shielding door. The robotic arm is a sword-type robotic arm. The detection methods of the activity detection mechanism 4, endotoxin detection module 5, radionuclide detection module 6, and pH detection platform 7 are consistent with the existing detection methods, and will not be described in detail here.

[0033] In one embodiment of this solution, the sample platform moves horizontally by driving a track control, and the medicine placement position has a structure such as a spring clamping block for positioning the medicine bottle to ensure the stability of the medicine bottle placement.

[0034] In another embodiment of this solution, the workbench has an initial drug placement position and a waste collection device. The drug bottles to be tested are placed in the initial drug placement position, and all kinds of waste are collected in the waste collection device. At the same time, the protective shell is also provided with an aluminum glass observation window, which allows the operator to observe through the window.

[0035] Preferably, the workbench 1 is further provided with a liquid extraction and injection mechanism, which includes a syringe connecting plate 13 for placing the syringe 12, a first lifting rail 14 located on one side of the syringe connecting plate 13, and a second lifting rail 15 connected to the syringe handle, so that the syringe 12 can sample or inject the medicine bottle 10.

[0036] Specifically, when sampling the medicine in the medicine bottle, the first and second lifting tracks descend synchronously, causing the syringe to move down and puncture into the medicine bottle. Then, the second lifting track rises separately to pull the syringe handle to take a sample. After sampling, the syringe is moved up again by the synchronous rise of the first and second lifting tracks to complete the sampling operation. Then, the medicine transport mechanism moves horizontally so that the syringe is aligned with the reagent bottle. The syringe can then be controlled by the first and second lifting tracks to inject the medicine into the designated reagent bottle.

[0037] The first and second lifting tracks are electrically operated.

[0038] In one embodiment of this solution, positioning blocks 29 are symmetrically arranged on the side of the syringe connecting plate 13. The syringe 12 is snapped between the two positioning blocks 29, and the side of the positioning block 29 near the syringe 12 has a spring ball 30, so that when the syringe is snapped between the two positioning blocks, the syringe can be positioned by the spring ball, and the subsequent replacement of the syringe by the sword-type robotic arm is convenient.

[0039] Preferably, the medicine placement position 9 is rotatably configured so that when the syringe 12 samples the medicine bottle 10, the medicine placement position 9 causes the medicine bottle 10 to rotate and tilt.

[0040] Specifically, when the syringe is used to sample the medicine bottle, the medicine placement position is used to tilt the medicine bottle at a certain angle in advance, so that the needle of the syringe can be inserted to the bottom of the medicine bottle, ensuring that the syringe completely samples the medicine in the medicine bottle.

[0041] The medicine placement area is rotated by a motor.

[0042] Preferably, the workbench 1 is also provided with a medicine bottle opening mechanism. The medicine bottle opening mechanism includes a positioning platform 16 located on one side of the sample platform 8 and an inclined surface 17 located on the side of the positioning platform 16 close to the sample platform 8. The inclined surface 17 matches the cap of the medicine bottle 10 so that when the medicine bottle 10 passes the positioning platform 16, the cap of the medicine bottle 10 is opened along the inclined surface 17.

[0043] Specifically, after the medicine bottle is placed in the medicine placement position, the sample platform moves the medicine bottle towards the positioning platform, so that the cap of the medicine bottle contacts the inclined surface. Then, during the movement, the inclined surface pushes the cap upward, thus opening the medicine bottle.

[0044] Preferably, the workbench 1 is also provided with a reagent bottle opening mechanism, which includes a horizontally movable opening slide 18, a lifting opening slide 19 that is lifted and lowered on one side of the horizontal opening slide 18, and an opening gripper 20 that is rotatably disposed on one side of the lifting opening slide 19, so that after the opening gripper 20 grabs the cap of the reagent bottle 11, it drives the cap of the reagent bottle 11 to rotate and rise to open the cap; the sample platform 8 has a reagent bottle gripper 21 so that when the reagent bottle 11 is opened, the reagent bottle gripper 21 holds the bottom of the reagent bottle 11.

[0045] Specifically, when opening the various reagent bottles at the sample platform, the sample platform moves the reagent bottles to the underside of the opening gripper. The lifting opening slide moves the opening gripper downward, allowing the opening gripper to pick up the cap of the corresponding reagent bottle. Then, the opening gripper, in conjunction with the lifting opening slide, rotates the cap upward, thereby completing the opening action of the reagent bottle.

[0046] Meanwhile, due to the design of the reagent bottle grippers, the body of the reagent bottle is fixed when the cap rotates and rises, preventing the reagent bottles from rising synchronously.

[0047] The horizontal and vertical opening slides are both electric tracks, the opening grippers are electric grippers and rotated by a motor, and the reagent bottle grippers are controlled by a double-headed cylinder.

[0048] In one embodiment of this solution, an additional set of horizontal opening slides can be added between the horizontal opening slide and the lifting opening slide, so that the two sets of horizontal opening slides and the lifting opening slide together form a drive track of X, Y, and Z axes, thereby controlling the opening operation of reagent bottles in different rows and columns.

[0049] Preferably, the workbench 1 is also provided with a pipetting mechanism, which includes a three-axis moving slide 22 and a pipette 23 disposed on one side of the three-axis moving slide 22, so that the pipette 23 can pipette between reagent bottles 11 and between reagent bottles 11 and detection positions.

[0050] Specifically, the pipette is moved to the top of the corresponding reagent bottle by a three-axis moving slide, and then the medicine in the corresponding reagent bottle is transferred to the designated testing institution for testing to ensure testing efficiency.

[0051] It is worth mentioning that when there are multiple rows of reagent bottles in the sample platform, the syringe injects the medicine into each reagent bottle in the middle row. Then the sample platform moves to the pipette, and the pipette, in conjunction with the three-axis moving slide, distributes the medicine in the reagent bottles in the middle row to the reagent bottles in the other rows.

[0052] The three-axis moving slide can move relative to the X, Y, and Z axes to ensure stable and accurate pipetting.

[0053] Preferably, a camera 24 is also provided on one side of the three-axis moving slide 22 so that the detection process, such as pH detection, can be photographed and recorded by the camera.

[0054] Preferably, the activity detection mechanism 4 includes a lifting platform 25 with lifting and lowering, a placement slot 26 on the lifting platform 25, and an activity detector 27 located below the lifting platform 25, so that after the medicine is placed in the placement slot 26, the lifting platform 25 drives the medicine down to the activity detector 27 for activity detection.

[0055] Specifically, when conducting activity testing on a drug, the drug bottle to be tested is placed in a placement slot, and then a lifting platform lowers the drug bottle into the activity detector, whereby the activity of the drug is tested.

[0056] When the drug to be tested is subjected to specific activity testing, the operator uses a sword-shaped robotic arm to place the drug bottle on the activity detector 27 for testing, and then uses the sword-shaped robotic arm to place the drug bottle on the drug transport mechanism. The drug transport mechanism moves to below the liquid collection and injection mechanism, which descends to remove the liquid from the drug bottle. The drug transport mechanism moves the sample platform 8 to below the liquid collection and injection mechanism, and the syringe injects the extracted drug liquid into the sample bottle containing the reagent. The operator then uses the sword-shaped robotic arm to place the sample bottle on the activity detector 27 again to test the drug activity and compare it with the first test.

[0057] When the drug to be tested is subjected to half-life testing, the operator uses a sword-shaped robotic arm to place the drug bottle on the activity detector 27 for testing, and then uses the sword-shaped robotic arm to place the drug bottle on the drug transport mechanism. The drug transport mechanism moves to below the liquid extraction and injection mechanism, which descends to extract the liquid from the drug bottle. The drug transport mechanism then moves the sample platform 8 to below the liquid extraction and injection mechanism, and the syringe injects the extracted drug liquid into the sample bottle containing the reagent. A decay time is preset, and after the decay time has elapsed, the operator uses the sword-shaped robotic arm to place the sample bottle on the activity detector 27 again to test the drug activity.

[0058] Preferably, the sample platform 8 has several cover placement positions 28 on its top, and the cover placement positions 28 correspond to the covers of the reagent bottles 11.

[0059] Specifically, when the reagent bottle is opened using the reagent bottle opening mechanism, the opening gripper removes the cap of the reagent bottle and places it in the cap placement position to ensure convenient subsequent cleaning.

[0060] This utility model is not limited to the above-described preferred embodiments. Anyone can derive other forms of products under the guidance of this utility model. However, regardless of any changes made in their shape or structure, any technical solution that is the same as or similar to this application falls within the protection scope of this utility model.

Claims

1. An automatic detection device for radiopharmaceuticals, characterized in that: The device includes a workbench (1) and a protective shell (2) located outside the workbench (1). The workbench (1) is provided with an activity detection mechanism (4) and / or an endotoxin detection module (5) and / or a radionuclide detection module (6) and / or a pH detection platform (7) in sequence. The workbench (1) also has a drug transport mechanism, which includes a movable sample platform (8) and a drug placement position (9) located on one side of the sample platform (8). After the drug bottle (10) to be tested is placed in the drug placement position (9), the drug is sampled sequentially to each reagent bottle (11) at the sample platform (8) for testing.

2. The automatic detection equipment for radiopharmaceuticals according to claim 1, characterized in that: A robotic arm (3) is provided extending inward on the protective shell (2). A liquid injection mechanism is also provided on the workbench (1). The liquid injection mechanism includes a syringe connecting plate (13) for placing a syringe (12), a first lifting rail (14) located on one side of the syringe connecting plate (13), and a second lifting rail (15) connected to the syringe handle, so that the syringe (12) can sample or inject the medicine bottle (10).

3. The automatic detection equipment for radiopharmaceuticals according to claim 2, characterized in that: The drug placement position (9) is rotatable so that when the syringe (12) samples the drug bottle (10), the drug placement position (9) causes the drug bottle (10) to rotate and tilt.

4. The automatic detection equipment for radiopharmaceuticals according to claim 1, characterized in that: The workbench (1) is also equipped with a medicine bottle opening mechanism. The medicine bottle opening mechanism includes a positioning platform (16) located on one side of the sample platform (8) and an inclined surface (17) located on the side of the positioning platform (16) close to the sample platform (8). The inclined surface (17) matches the cap of the medicine bottle (10) so that when the medicine bottle (10) passes the positioning platform (16), the cap of the medicine bottle (10) is opened along the inclined surface (17).

5. The automatic detection equipment for radiopharmaceuticals according to claim 1, characterized in that: The workbench (1) is also equipped with a reagent bottle opening mechanism, which includes a horizontal opening slide (18) that moves horizontally, a lifting opening slide (19) that is lifted and lowered on one side of the horizontal opening slide (18), and an opening gripper (20) that is rotatably set on one side of the lifting opening slide (19), so that after the opening gripper (20) grabs the cap of the reagent bottle (11), it drives the cap of the reagent bottle (11) to rotate and rise to open the cap; the sample platform (8) has a reagent bottle gripper (21) so that when the reagent bottle (11) is opened, the reagent bottle gripper (21) holds the bottom of the reagent bottle (11).

6. The automatic detection equipment for radiopharmaceuticals according to claim 1, characterized in that: The workbench (1) is also equipped with a pipetting mechanism, which includes a three-axis moving slide (22) and a pipette (23) located on one side of the three-axis moving slide (22) so that the pipette (23) can pipette between reagent bottles (11) and between reagent bottles (11) and the detection position.

7. The automatic detection device for radiopharmaceuticals according to claim 6, characterized in that: A camera (24) is also provided on one side of the three-axis moving slide (22).

8. The automatic detection equipment for radiopharmaceuticals according to claim 1, characterized in that: The activity detection mechanism (4) includes a lifting platform (25) with lifting and lowering, a placement slot (26) on the lifting platform (25), and an activity detector (27) located on the lower side of the lifting platform (25), so that after the medicine is placed in the placement slot (26), the lifting platform (25) drives the medicine down to the activity detector (27) for activity detection.

9. The automatic detection device for radiopharmaceuticals according to claim 1, characterized in that: The sample platform (8) has several cover placement positions (28) on its top, and the cover placement positions (28) correspond to the covers of the reagent bottles (11).

10. The automatic detection device for radiopharmaceuticals according to claim 2, characterized in that: The syringe connecting plate (13) is symmetrically provided with positioning blocks (29) on its side. The syringe (12) is snapped between the two positioning blocks (29), and the side of the positioning block (29) near the syringe (12) has a spring ball (30).

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