Head model for treating object by near-infrared light
By designing a head model for near-infrared light therapy, the problem of inaccurate light power density measurement was solved, enabling precise evaluation of near-infrared light therapy equipment and rational formulation of treatment plans, suitable for different patients.
Patent Information
- Application Number
- CN202422511200.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-10-16
- Publication Date
- 2026-02-06
- Estimated Expiration
- 2034-10-16
AI Technical Summary
Existing near-infrared light therapy equipment has vague and confusing definitions of irradiation parameters, making it difficult to accurately measure light power density. Furthermore, it is affected by the size, shape, and skin color of the patient's head, which hinders the promotion and development of near-infrared light therapy.
A head model for near-infrared light therapy was designed. The deviation between the surface absorptivity of the head model and the preset absorptivity is less than a threshold. It has a mounting position for an optical power meter, and the structure is recessed relative to the reference head model to adapt to the thickness of the optical power meter probe. The electrode positions are marked for accurate measurement of light attenuation and transmission.
It enables convenient and accurate evaluation of near-infrared light therapy devices, allows for the rational development of treatment plans, ensures the accuracy of light power density, and is suitable for patients of different skin colors.
Smart Images
Figure CN223874261U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The present application relates to the technical field of medical devices, in particular to a head mold for near-infrared light treatment. BACKGROUND
[0002] Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disease that mainly affects the elderly, especially people over 60 years old. The disease is characterized by memory loss, loss of social and occupational functioning, reduced executive function, speech and motor deficits, personality changes, and behavioral and psychological disorders. The deterioration process can last for 8-10 years, and there is currently no complete cure, which brings a heavy burden to families and society.
[0003] In recent years, photobiomodulation (PBM) has been introduced to treat AD, which is to apply red or near-infrared light with a wavelength range of 600 to 1100 nm to the head, through the scalp and skull to the brain tissue, to treat AD non-invasively through various mechanisms, such as increasing Aβ clearance, reducing abnormal aggregation of Tau protein, improving metabolism and mitochondrial function, increasing cerebral blood flow, improving antioxidant stress and anti-inflammatory capacity, etc.
[0004] However, the irradiation parameters of existing various photobiomodulation devices (also referred to as light treatment devices herein) are ambiguous, confusing and vary greatly. On the one hand, the existing detection devices are difficult to accurately measure the optical power density of the near-infrared light that can actually be irradiated to the patient's head, and on the other hand, the optical power density of the near-infrared light actually acting on the patient's head is also affected by the size, shape and even skin color of the patient's head. These technical problems hinder the promotion and development of near-infrared light treatment devices and even near-infrared light treatment methods. CONTENT OF THE UTILITY MODEL
[0005] The present application aims to provide a head mold for near-infrared light treatment of an object, which can conveniently attach a probe of an optical power meter with a thickness of several mm to the surface of the head mold to determine the optical power density that the reference head mold should have.
[0006] According to a first aspect of the present application, a head mold for near-infrared light treatment of an object is provided, the deviation between the absorption rate of the surface of the head mold for near-infrared light and the preset absorption rate is less than a preset threshold value, the upper surface of the head mold has a mounting position for an optical power meter, the optical power meter is used to measure the light attenuation and transmission in the accommodation space of the near-infrared light treatment device, and the structure of at least the upper part of the head mold is recessed by a predetermined size relative to the structure of the reference head mold, the predetermined size is adapted to the thickness of the probe of the optical power meter, and the structure parameters of the reference head mold include: the head circumference is any value in the range of 525-583 mm, the head length is any value in the range of 170-196 mm, and the head width is any value in the range of 140-166 mm.
[0007] Exemplarily, the plurality of electrode positions are marked on the head mold and are externally visible.
[0008] Exemplarily, the plurality of electrode positions are marked on the head mold and are externally visible.
[0009] Exemplarily, the plurality of electrode positions are marked on the head mold and are externally visible.
[0010] Exemplarily, the plurality of electrode positions are marked on the head mold and are externally visible.
[0011] Exemplarily, the plurality of electrode positions are located in the inner portion of the head mold.
[0012] Exemplarily, the upper portion of the head mold corresponds to at least one of the upper front portion of the skull, the top portion of the skull, the left side portion of the skull, the right side portion of the skull and the back portion of the skull of the near-infrared light treatment subject.
[0013] Exemplarily, the lower structure of the head mold is equivalent to the lower structure of the reference head mold, and the boundary line between the upper portion and the lower portion of the head mold is located in the accommodation space during the measurement.
[0014] Exemplarily, the head mold is structurally recessed by a predetermined size relative to the reference head mold as a whole.
[0015] Exemplarily, the preset absorption rate is adapted to the absorption rate of the head surface of the population represented by the near-infrared light treatment subject to near-infrared light.
[0016] Exemplarily, the surface of the head mold is black, and the head length-width index composed of the head length and the head width is 81.0-85.4.
[0017] Exemplarily, the morphological face length is any value in the range of 104-130 mm; the head sagittal arc is any value in the range of 304-372 mm; the intertragal arc is any value in the range of 320-375 mm; and the head height is any value in the range of 206-253 mm.
[0018] Exemplarily, the structural parameters of the reference head mold specifically include: the morphological face length is 104-111.9 mm, the head sagittal arc is 348.8-362.4 mm, the intertragal arc is 320-329.6 mm, and the head height is 206-210.7 mm.
[0019] Exemplarily, the structural parameters of the reference head mold specifically include: the head circumference is 536.7 mm, the head length is 184 mm, and the head width is 152 mm.
[0020] Exemplarily, the head width and the head length in the structure parameters of the reference headform are both determined based on the mean of the P50 parameter values of the head width and the head length of the females in the age range of 61-70 years old and the P50 parameter values of the head width and the head length of the males in the age range of 61-70 years old.
[0021] Exemplarily, one or more of the following is marked on the head model and visible externally: a total separation line, a first separation line, a second separation line, a third separation line, a fourth separation line, and a fifth separation line, wherein: the total separation line passes through the glabella point of the head model, along the malar bone, through the preauricular points on both sides, and then converges by going around the inion, and the electrode positions O1, OZ, and O2 of the 10-10 international standard lead system; the first separation line passes through the electrode positions F7 and FT7, the electrode positions F5 and FC5, the electrode positions FC3 and C3, the electrode positions FC1 and C1, the electrode positions FCZ and CZ, the electrode positions FC2 and C2, the electrode positions FC4 and C4, the electrode positions F6 and FC6, and the electrode positions F8 and FT8 of the 10-10 international standard lead system in sequence; the second separation line passes through the electrode positions FC3 and C3, the electrode positions FC1 and C1, the electrode positions FCZ and CZ, the electrode positions FC2 and C2, the electrode positions FC4 and C4, the electrode positions C6 and C4, the electrode positions CP6 and CP4, the electrode positions P6 and P4, the electrode positions PO4 and P4, the electrode positions PO4 and P2, the electrode positions POZ and P2, the electrode positions POZ and PZ, the electrode positions POZ and P1, the electrode positions PO3 and P1, the electrode positions PO3 and P3, the electrode positions P5 and P3, the electrode positions CP5 and CP3, and the electrode positions C5 and C3 of the 10-10 international standard lead system in sequence; the third separation line passes through the electrode positions FT7 and F7, the electrode positions FC5 and F5, the electrode positions FC5 and FC3, the electrode positions C5 and C3, the electrode positions CP5 and CP3, the electrode positions P5 and P3, the electrode positions P5 and PO5, the electrode positions P7 and PO7 of the 10-10 international standard lead system in sequence; the fourth separation line passes through the electrode positions FT8 and F8, the electrode positions FC6 and F6, the electrode positions FC6 and FC4, the electrode positions C6 and C4, the electrode positions CP6 and CP4, the electrode positions P6 and P4, the electrode positions P6 and PO6, the electrode positions P8 and PO8 of the 10-10 international standard lead system in sequence; and the fifth separation line passes through the electrode positions P7 and PO7, the electrode positions P5 and PO5, the electrode positions P3 and PO3, the electrode positions P1 and POZ, the electrode positions PZ and POZ, the electrode positions P2 and POZ, the electrode positions P4 and PO4, the electrode positions P6 and PO6, and the electrode positions P8 and PO8 of the 10-10 international standard lead system in sequence.
[0022] Exemplarily, the partition lines are configured to satisfy one or more of the following conditions: the area enclosed by the first partition line and the total partition line corresponds to the upper anterior part of the skull of the near-infrared light treatment subject; the area enclosed by the second partition line corresponds to the parietal part of the skull of the near-infrared light treatment subject; the area enclosed by the third partition line and the total partition line corresponds to the left part of the skull of the near-infrared light treatment subject; the area enclosed by the fourth partition line and the total partition line corresponds to the right part of the skull of the near-infrared light treatment subject; and the area enclosed by the fifth partition line and the total partition line corresponds to the posterior part of the skull of the near-infrared light treatment subject. Thus, the performance of the near-infrared light treatment device can be evaluated more conveniently and accurately by using the head model, and the near-infrared light treatment device can be improved accordingly. By using the head model, the treatment scheme of the near-infrared light can also be more reasonably formulated. For other devices that irradiate the head for light treatment, the head model can also play a certain evaluation role.
[0023] A series of simplified concepts are introduced in the utility model content, which will be further described in detail in the specific embodiment part. The utility model content part does not mean trying to limit the key features and necessary technical features of the claimed technical solutions, and even less means trying to determine the protection scope of the claimed technical solutions.
[0024] The advantages and features of the present application will be described in detail below in combination with the drawings. BRIEF DESCRIPTION OF DRAWINGS
[0025] The following drawings of the present application are hereby incorporated into the present application as part of the present application for understanding the present application. The embodiments of the present application and the description thereof shown in the drawings are used to explain the principles of the present application. In the drawings,
[0026] Figure 1 A schematic diagram of a head model of a first embodiment of the present application is shown;
[0027] Figures 2(a)-2(f) A diagram showing characteristic parameters of a head model of a subject or a subject population according to a second embodiment of the present application is shown;
[0028] Fig. 3(a) shows a front view of a reference head model as an example of a subject head, on which the electrode positions of the 10-10 international standard lead system, the total boundary line of the reference head cover part, and the boundary lines between the upper anterior part, the left part of the skull and the right part of the skull are shown, according to a third embodiment of the present application;
[0029] Fig. 3(b) shows a left side view of a reference head model as an example of a subject head, on which the electrode positions of the 10-10 international standard lead system, the total boundary line of the reference head cover part, and the boundary lines between the upper anterior part, the left part of the skull, the parietal part and the posterior part of the skull are shown, according to a third embodiment of the present application;
[0030] Fig. 3(c) shows a right side view of the reference head model as an example of the object head, on which the electrode positions of the 10-10 international standard lead system, the total boundary line of the reference head cover part, and the boundary lines among the upper front part of the skull, the right part of the skull, the top part of the skull, and the back part of the skull are shown, according to the third embodiment of the present application;
[0031] Fig. 3(d) shows a top view of the reference head model as an example of the object head, on which the electrode positions of the 10-10 international standard lead system, the total boundary line of the reference head cover part, and the boundary lines among the upper front part of the skull, the top part of the skull, the left part of the skull, the right part of the skull, and the back part of the skull are shown, according to the third embodiment of the present application;
[0032] Fig. 3(e) shows a back view of the reference head model as an example of the object head, on which the electrode positions of the 10-10 international standard lead system, the total boundary line of the reference head cover part, and the boundary lines among the top part of the skull, the left part of the skull, the right part of the skull, and the back part of the skull are shown, according to the third embodiment of the present application. DETAILED DESCRIPTION
[0033] In the following description, a large number of details are provided in order to allow a thorough understanding of the present application. However, it can be appreciated by those skilled in the art that the following description only shows the preferred embodiments of the present application in some embodiments, and the present application can be implemented without one or more such details. In addition, in order to avoid confusion with the present application, some technical features known in the art are not described in detail.
[0034] To at least partially solve the above technical problems, the present application provides a head model for near-infrared light treatment of an object. The deviation between the absorption rate of the surface of the head model for near-infrared light and the preset absorption rate is less than a preset threshold. The preset absorption rate can be the absorption rate of the skin of a real human body for near-infrared light, or close to the absorption rate of the skin of a real human body for near-infrared light. For the same near-infrared light treatment device, it is detected in experiments that the reflectivity of the head of a human body for near-infrared light is low. Using the same operation to irradiate to the head model of the same size, the surface light power density measured by the head model with aluminum foil pasted on the surface is 5-12 mW / cm 2 This can be due to the reflection of near-infrared light between the surface of the head model and the near-infrared light treatment device, resulting in superposition of the near-infrared light reaching the detection device. The above measurement shows that the absorption rate of the surface of the head model for near-infrared light will affect the actual measured light power density. The preset threshold can fall within the range of the difference between the absorption rate of the skin of different skin color population for near-infrared light and the preset absorption rate. In some embodiments, the measured light power density can also be calibrated according to the absorption rate and reflectivity of the skin of the head of a real human body.
[0035] The upper surface of the head mold has a mounting position for an optical power meter, which is used to measure light attenuation and transmission within the space housing the near-infrared light therapy device. Compared to simply attaching sensors directly to the head mold surface, standard optical power meter probes, due to their mature technology, can achieve higher detection accuracy through calibration. However, the probes are typically quite thick. If placed directly on a head mold proportional to a real human head, the detection surface may be too close to the light source of the near-infrared light therapy device, resulting in a discrepancy between the detected light power density and the actual light power density received by the subject's head. Furthermore, the measurement accuracy will be even worse when there is superposition of near-infrared light shining on the head.
[0036] Figure 1 A schematic diagram of an exemplary head mold is shown. This head mold is designed for use with a near-infrared light therapy device, targeting the upper part of the subject's head. Therefore, at least the upper part of the head mold's structure is recessed by a predetermined dimension relative to a reference head mold. The reference head mold refers to a head mold that is the same size as the head of the subject undergoing near-infrared light therapy. Figure 1 As shown in the diagram, the dashed lines indicate the dimensions of the base head mold, and the solid lines enclosed by the dashed lines represent the recessed portion. This reduces manufacturing costs for head molds manufactured by means of machining, for example, especially when modifying a base head mold to have a recessed portion. Figure 1 The measurement target area is only specified in the middle. Figure 1 The area above the ears (the head cover region) has been shrunk inwards, but this is just an example. The entire surface of the head cover of the head model can also be shrunk inwards, while the face is adaptively reduced.
[0037] The head molds with recessed portions according to various embodiments of this application differ significantly from other head molds (e.g., in size or shape), making them less prone to misuse or confusion. A predetermined size is adapted to the thickness of the probe of the optical power meter. Thus, when the probe is positioned in the recessed portion of the head mold, its detection surface is precisely located in space on the surface corresponding to the reference head mold surface. This allows for more accurate measurement of the optical power density on the corresponding surface of the near-infrared light therapy subject's head.
[0038] The present application is directed to a near-infrared light treatment device that accommodates a head in an accommodation space and applies near-infrared light for treatment. In the case of an embodiment in which the head of a subject is inserted into the accommodation space from below, the length, width and circumference of the head of the subject need to be taken into account. Otherwise, it can be impossible to wear the device, or it can be uncomfortable to wear. In the case of a head model, it is necessary to ensure that, when a detection probe is arranged on the head model, the detection surface of the detection probe is in the same position relative to the near-infrared light treatment device as the surface of a real human head. The structural parameters of the reference head model include: the circumference of the head is any value in the range of 525-583 mm, the length of the head is any value in the range of 170-196 mm, and the width of the head is any value in the range of 140-166 mm. The various parameters are shown schematically in Figures 2(a)-2(c) On the basis of the reference head model, a head model having a recessed portion can have a length and width that are 1-2 probe thicknesses smaller (the positions at which the length and width are measured are included in the recessed portion).
[0039] Thus, the performance of a near-infrared light treatment device can be evaluated more conveniently and accurately using the head model, and the near-infrared light treatment device can be improved. The head model can also be used to develop a more reasonable treatment plan for near-infrared light. The head model can also be used to evaluate other devices that irradiate the head for light treatment.
[0040] Exemplarily, a plurality of electrode positions are marked on the head model and are visible from the outside. The plurality of electrode positions can be electrode positions of the 10-20 international standard electrode system, or electrode positions of the 10-10 international standard electrode system. The 10-10 international standard electrode system is an electrode placement standard for electroencephalogram (EEG) recording, which provides an accurate and consistent way to mark and position electrodes on the head. That is, the 10-10 system can be applied directly to the head of a subject without transcranial application. This system is an extension of the earlier 10-20 system, which was proposed by the International Society for Electroencephalography to standardize electrode positions in EEG recordings.
[0041] Therefore, simulations or modeling can be performed based on the details of the intended localized concentrated stimulation scheme or multi-zone balanced stimulation scheme. The structure of the phototherapy equipment, especially the three-dimensional spatial arrangement of the lamp panels, can be adjusted based on the simulation results to ensure that the designed phototherapy equipment meets the required synergistic irradiation conditions under the intended implementation scheme. After such verification, a prototype of the designed phototherapy equipment can be manufactured, and the prototype can be used to irradiate a physical head model for actual verification. It is understood that if the actual verification results on the physical head model are good, given that the head model's size is well representative of the individual head sizes of the treatment population (for example, the parameters of the treatment population's head are 80% to 120% of the parameters of the head model), the results of subsequent phototherapy tests on the treatment population will have a high degree of consistency. This manufacturing process can balance manufacturing costs and treatment effectiveness.
[0042] To ensure measurement accuracy, it may be necessary to detect every point on the head mold surface as much as possible during the measurement process. Specifically, the probe can be placed around the electrode position markers, or placed on top of the electrode position markers. Exemplarily, the markers for multiple electrode positions do not protrude from the head mold surface. This avoids a situation where the probe's detection surface is higher when placed on the electrode position markers than when placed in other positions, thus preventing reduced measurement accuracy. In other embodiments, the markers for multiple electrode positions may protrude from the head mold surface, but the protrusion height does not exceed a predetermined size. Increasing the probe's detection surface height by the predetermined size may not affect the detection results. Alternatively, the predetermined size can be set according to the differences in head sizes between different subjects to simulate the light power density of the head surface corresponding to different populations. Exemplarily, some of the markers for multiple electrode positions do not protrude from the head mold surface, while others protrude from the head mold surface by a height not exceeding a predetermined size. Of course, embodiments where the markers for multiple electrode positions do not protrude from the head mold surface also include cases where the markers are recessed into the head mold surface.
[0043] The recessed portion of the head mold is used to house the probe, and multiple electrode positions are used to identify where the probe should be placed. Thus, exemplarily, the multiple electrode positions are located within the recessed portion of the head mold.
[0044] For example, the upper part of the head mold corresponds to at least a portion of the upper anterior skull, top skull, left side skull, right side skull, and posterior skull of the near-infrared light therapy subject. These portions correspond to the irradiation areas of the head of the near-infrared therapy subject by common near-infrared therapy devices. The upper anterior skull, top skull, left side skull, right side skull, and posterior skull will be described in detail below.
[0045] Exemplarily, the lower structure of the headform is comparable to that of the reference headform, and the demarcation line between the upper and lower portions of the headform is located within the accommodation space during the measurement. This embodiment makes the portion of the headform exposed outside the near-infrared therapeutic device during the process of wearing the near-infrared therapeutic device have the same size as the portion of the reference headform or the portion exposed outside when worn by the patient, thereby facilitating the determination of whether the headform is in place in the accommodation space according to the positions of the head features (e.g., the brow, the external occipital protuberance, etc.). In the process of cooperating with some near-infrared therapeutic devices, the lower portion that is not retracted can prevent the leakage of near-infrared light as when worn by the subject's head. In one embodiment, the demarcation line between the upper and lower portions of the headform can be the total separation line as described below, and in another embodiment, the demarcation line between the upper and lower portions of the headform is lower or higher than the total separation line. In some embodiments, the headform is retracted by a predetermined size in structure relative to the reference headform as a whole. This design and manufacture are simpler.
[0046] Through clinical investigation and statistical analysis, the concentrated age range of AD patients is above 60 years old. For this age range of the treated population, representative head parameters are selected, which can greatly reduce the workload. Exemplarily, the head width and head length of the reference headform are determined based on the average of the P50 parameter values of the head width and head length of females in the age range of 61-70 years old and the P50 parameter values of the head width and head length of males in the age range of 61-70 years old.
[0047] Specifically, the parameter range of the reference headform falls within the intersection of the distribution ranges of the P1, P5, P10, P50, P90, P95, and P99 parameter values of females in this age range and the P1, P10, P50, P90, P95, and P99 parameter values of males in this age range, and thus is representative for both males and females in this age range. Specifically, the structural parameters of the reference headform further include: the morphological face length being any value in the range of 104-130 mm, the head sagittal arc being any value in the range of 304-372 mm, the inter-tragus arc being any value in the range of 320-375 mm, and the head height being any value in the range of 206-253 mm.
[0048] Exemplarily, the structural parameters of the reference headform specifically include: the morphological face length being 104-111.9 mm, the head sagittal arc being 348.8-362.4 mm, the inter-tragus arc being 320-329.6 mm, and the head height being 206-210.7 mm. Each of the parameters herein is schematically shown in FIG. 1. Figures 2(d)-2(f)
[0049] For example, the preset absorption rate can be adapted to the absorption rate of the head surface of the represented near-infrared light treatment subject population to near-infrared light. For example, for a yellow race as the treatment subject, the preset absorption rate can be determined according to the absorption rate of the subject with the darkest skin color to near-infrared light and the absorption rate of the subject with the lightest skin color to near-infrared light. Specifically, the preset absorption rate can be the average of the above two, and the preset threshold is not greater than the difference between any one of the above two and the preset absorption rate.
[0050] For example, the head model surface can be configured to be black. In this way, the head model is simple to manufacture and has low cost. As described above, the head model surface configured to be black makes the actually measured light power density of the near-infrared light the lowest, so that the lower limit of the light power density of the near-infrared light output by the near-infrared light treatment device can be determined according to the value. This can ensure that even if the skin color of the subject is dark, the head surface of the subject can also receive a sufficient dose of near-infrared light irradiation to ensure the treatment effect. The head length and head width dimensions constitute a head length-width index of 81.0-85.4. Further, the head-facial index of this parameter can be 82%, which also coincides with the head-facial index range of the dominant head type in Chinese people (even East Asian population) - round head type (Brachycephaly). Therefore, the parameters of the head model have particularly good representativeness in Chinese and East Asian populations.
[0051] For example, the parameters of the reference head model can be further refined as follows: the head width is 152 mm, the head length is 184 mm, the head circumference is 536.7 mm, the morphological face length is 109.3 mm, the head sagittal arc is 355.6 mm, the inter-tragus arc is 324.1 mm, and the head height is 206 mm. The refined parameters are determined based on the P50 parameter values of females in this age group and the P50 parameter values of males in this age group, wherein the head width and the head length are the average of the two corresponding P50 parameter values. The P50 parameter values of females in this age group are as follows: the head width is 149 mm, the head length is 180 mm, the head circumference is 548 mm, the morphological face length is 111 mm, the head sagittal arc is 335 mm, the inter-tragus arc is 342 mm, and the head height is 228 mm. The P50 parameter values of males in this age group are as follows: the head width is 155 mm, the head length is 188 mm, the head circumference is 565 mm, the morphological face length is 121 mm, the head sagittal arc is 343 mm, the inter-tragus arc is 351 mm, and the head height is 231 mm. Therefore, for example, the head circumference of the head model can be 536.7 mm, the head length can be 184 mm, and the head width can be 152 mm. It can be seen that the parameters of the head model have good consistency with the P50 parameters of females and males in this age group, and thus are more representative. The head model manufactured based thereon can obtain measurement data suitable for most subjects.
[0052] Exemplarily, the head model can also be marked with a separation line. The head model can be marked with one or more of a total separation line, a first separation line, a second separation line, a third separation line, a fourth separation line, and a fifth separation line, so as to facilitate determination of the parts corresponding to the brain regions.
[0053] The separation line is configured to satisfy one or more of the following conditions:
[0054] 1) the region enclosed by the first separation line and the total separation line corresponds to the upper front part of the skull of the near-infrared light treatment subject;
[0055] 2) the region enclosed by the second separation line corresponds to the top part of the skull of the near-infrared light treatment subject;
[0056] 3) the region enclosed by the third separation line and the total separation line corresponds to the left part of the skull of the near-infrared light treatment subject;
[0057] 4) the region enclosed by the fourth separation line and the total separation line corresponds to the right part of the skull of the near-infrared light treatment subject;
[0058] 5) the region enclosed by the fifth separation line and the total separation line corresponds to the back part of the skull of the near-infrared light treatment subject.
[0059] In some embodiments, the top part of the skull 300b is within the region enclosed by the second separation line 302c. The top part of the skull 300b occupies more than 60%, or more than 70%, or more than 80% of the surface area of the region.
[0060] In some embodiments, the left part of the skull 300c is within the region enclosed by the third separation line 302d and the total separation line 301, and the right part of the skull 300d is within the region enclosed by the fourth separation line 302e and the total separation line 301. Specifically, the left part of the skull 300c occupies more than 60%, or more than 70%, or more than 80% of the surface area of the region enclosed by the third separation line 302d and the total separation line 301, and the right part of the skull 300d occupies more than 60%, or more than 70%, or more than 80% of the surface area of the region enclosed by the fourth separation line 302e and the total separation line 301.
[0061] The total separation line passes through the preaurale points on both sides of the glabella point of the head model along the superciliary arch, and converges after passing around the inion and the electrode positions O1, OZ, and O2 of the 10-10 international standard electrode system. As shown in FIG. 3, the total separation line includes most of the important target points of the near-infrared light treatment within it, and the near-infrared light treatment device can irradiate towards the range defined by the total separation line to cover the whole brain treatment. Figures 3(a)-3(e) As shown in FIG. 3, the total separation line includes most of the important target points of the near-infrared light treatment within it, and the near-infrared light treatment device can irradiate towards the range defined by the total separation line to cover the whole brain treatment. As described above, the head model is provided with a retracted portion. In order to clearly show the positions of the points, Figures 3(a)-3(e)The headform shown does not show the retracted portion, or it can be considered that the headform shown in the figure is a reference headform corresponding to the headform, and the actual headform sets the retracted area on the basis of the reference headform.
[0062] According to the 10-10 standard guide system, the first separation line 302b passes through the electrode positions F7 and FT7, the electrode positions F5 and FC5, the electrode positions FC3 and C3, the electrode positions FC1 and C1 (see FIG. 3(b)), the electrode positions FCZ and CZ (see FIG. 3(d)), the electrode positions FC2 and C2, the electrode positions FC4 and C4, the electrode positions F6 and FC6, and the electrode positions F8 and FT8 (see FIG. 3(c)) of the 10-10 international standard guide system in order.
[0063] The second separation line 302c passes through the electrode positions FC3 and C3, the electrode positions FC1 and C1, the electrode positions FCZ and CZ, the electrode positions FC2 and C2, the electrode positions FC4 and C4 (see FIG. 3(d)), the electrode positions C6 and C4, the electrode positions CP6 and CP4, the electrode positions P6 and P4 (see FIG. 3(c)), the electrode positions PO4 and P4, the electrode positions PO4 and P2, the electrode positions POZ and P2, the electrode positions POZ and PZ, the electrode positions POZ and P1, the electrode positions PO3 and P1, the electrode positions PO3 and P3 (see FIG. 3(e)), the electrode positions P5 and P3, the electrode positions CP5 and CP3, and the electrode positions C5 and C3 (see FIG. 3(b)) of the 10-10 international standard guide system in order.
[0064] The third separation line 302d passes through the electrode positions FT7 and F7, the electrode positions FC5 and F5, the electrode positions FC5 and FC3, the electrode positions C5 and C3, the electrode positions CP5 and CP3, the electrode positions P5 and P3, the electrode positions P5 and POS, the electrode positions P7 and POS (see FIG. 3(b)) of the 10-10 international standard guide system in order.
[0065] The fourth separation line 302e passes through the electrode positions FT8 and F8, the electrode positions FC6 and F6, the electrode positions FC6 and FC4, the electrode positions C6 and C4, the electrode positions CP6 and CP4, the electrode positions P6 and P4, the electrode positions P6 and P06, the electrode positions P8 and P08 (see FIG. 3(c)) of the 10-10 international standard guide system in order.
[0066] The fifth partition line 302a passes through the electrode positions P7 and PO7, P5 and PO5, P3 and PO3, PI and POZ, PZ and POZ, P2 and POZ, P4 and PO4, P6 and PO6, P8 and PO8, in order, between the electrode positions of the 10-10 international standard electrode system. (See FIG. 3(b), FIG. 3(c), and FIG. 3(e)).
[0067] In some embodiments, each of the sections can contain sparser electrode positions, that is, a shrunken coverage. For example, the prefrontal superior section 300a can contain the electrode positions AFZ, FZ, F1, F2, FP1, FP2, according to the 10-10 standard electrode system. The parietal section 300b contains the electrode positions CZ, C1, C2, and CPZ. The left temporal section 300c contains the electrode positions FT7, FC5, T7, C5, or TP7, CP5, P7, or P5, and the right temporal section 300d contains the electrode positions FT8, FC6, T8, C6, or TP8, CP6, P8, P6. Although the coverage of each section is shrunk, by providing sufficient time-averaged irradiance power to each section, it is still possible to break through the spatial separation and spread to the nearby core network nodes and brain areas of the default mode network (DMN), the central executive network (ECN, also known as the executive control network), the salience network (SN), the sensory-motor network (SMN), and the dorsal attention network (DAN), to perform AD inhibitory processing along the spread path of the functional connectivity area, such as inhibiting or eliminating the deposition of Aβ plaques, inhibiting or eliminating the abnormal aggregation of Tau protein, inhibiting or improving the tangle of neuronal fibers, and thus effectively inhibiting or cutting off the development process of neurodegenerative diseases caused by Aβ plaques and Tau protein abnormalities along the spread of the brain functional network.
[0068] In some embodiments, the prefrontal superior section 300a, the parietal section 300b, as well as the left temporal section 300c and the right temporal section 300d can be divided as needed based on the set of electrode positions contained therein. Please note that such division can be for the convenience of light therapy device light control, or for the specific structure of the light therapy device, especially the spatial arrangement of each unit in the array of near-infrared irradiation units. Thus, the set of electrode positions contained in each of the prefrontal superior section 300a, the parietal section 300b, as well as the left temporal section 300c and the right temporal section 300d can be flexibly divided, as long as it can cover or be sufficiently adjacent to the core network nodes and brain areas of the default mode network (DMN), the central executive network (ECN, also known as the executive control network), the salience network (SN), the sensory-motor network (SMN), and the dorsal attention network (DAN).
[0069] In the description of the present application, it should be understood that the orientation words such as "front", "back", "upper", "lower", "left", "right", "transverse", "vertical", "vertical", "horizontal" and "top", "bottom" and the like indicated orientation or position relationship is generally based on the orientation or position relationship shown in the drawings, only for the convenience of describing the present application and simplifying the description, without making the opposite statement, these orientation words do not indicate and imply that the device or device must have a particular orientation or be constructed and operated in a particular orientation, therefore, it cannot be understood as a limitation on the scope of protection of the present application; the orientation words "inner", "outer" refer to the inner and outer of the contour of each component itself.
[0070] For the convenience of description, the area relative terms such as "on", "above", "upper surface", "upper" and the like can be used herein to describe the area position relationship of one or more components or features shown in the figure with other components or features. It should be understood that the area relative terms not only include the orientation of the components described in the figure, but also include different orientations in use or operation. For example, if the components in the figure are inverted as a whole, the components "above" or "above" other components or features will include the components "below" or "below" other components or structures. Thus, the exemplary term "above" can include both "above" and "below". In addition, these components or features can also be positioned at other different angles (for example, rotated by 90 degrees or other angles), and all these cases are intended to be included herein.
[0071] It should be noted that the terms used herein are only for the purpose of describing specific embodiments, and are not intended to limit the exemplary embodiments according to the present application. As used herein, the singular form is intended to include the plural form unless the context clearly indicates otherwise, and furthermore, it should be understood that when the terms "comprise" and / or "include" are used in the specification, it means that the features, steps, operations, components, assemblies and / or combinations thereof are present.
[0072] The present application has been described by the above examples, but it should be understood that the above examples are only for the purpose of example and illustration, and are not intended to limit the present application to the scope of the described embodiments. In addition, those skilled in the art can understand that the present application is not limited to the above examples, and more variations and modifications can be made according to the teachings of the present application, which are all within the scope of the present application. The scope of protection of the present application is defined by the appended claims and their equivalent scope.
Claims
1. A head model for near-infrared light therapy, characterized in that, The deviation between the absorption rate of the head model surface to near-infrared light and the preset absorption rate is less than a preset threshold, the head model has a mounting position of a light power meter on the upper surface of the head model, the light power meter is used to measure the light attenuation and transmission in the accommodating space of the near-infrared light treatment device, and the structure of at least the upper part of the head model is recessed by a predetermined size relative to the structure of a reference head model, the predetermined size is adapted to the thickness of a probe of the light power meter, and the structure parameters of the reference head model include: the head circumference is any value in the range of 525-583 mm, the head length is any value in the range of 170-196 mm, and the head width is any value in the range of 140-166 mm.
2. The headform of claim 1, wherein The head model is marked with a plurality of electrode positions visible externally, and the plurality of electrode positions are electrode positions of the 10-20 international standard electrode system or the 10-10 international standard electrode system.
3. The head model of claim 2, wherein, the mark of the plurality of electrode positions is not prominent on the surface of the head model; or the height of the mark of the plurality of electrode positions protruding from the surface of the head model is not higher than the predetermined size; or the mark of a part of the plurality of electrode positions is not prominent on the surface of the head model, and the height of the mark of another part of the plurality of electrode positions protruding from the surface of the head model is not higher than the predetermined size. The plurality of electrode positions are located in the recessed part of the head model.
4. The headform of claim 2 or 3, wherein, The upper part of the head model corresponds to at least part of the front upper part, the top part, the left side part, the right side part and the back part of the skull of the near-infrared light treatment object.
5. The headform of any of claims 1-3, wherein, 6. The head model of any one of claims 1-3, wherein, the lower structure of the head model is equivalent to the lower structure of the reference head model, and the boundary line between the upper part and the lower part of the head model is located in the accommodating space during the measurement; or the head model is recessed by the predetermined size in structure as a whole relative to the reference head model.
7. The head model of any one of claims 1-3, wherein, the preset absorption rate is adapted to the absorption rate of the head surface of the population represented by the near-infrared light treatment object to near-infrared light; and / or the surface of the head model is black, and the head length-width index composed of the head length and the head width is 81.0-85.
4. The structure parameters of the reference head model further include:
8. The headform of any of claims 1-3, wherein, the morphological face length is any value in the range of 104-130 mm; the head sagittal arc is any value in the range of 304-372 mm; the inter-tragus arc is any value in the range of 320-375 mm; the head height is any value in the range of 206-253 mm. The structure parameters of the reference head model specifically include: the morphological face length is 104-111.9 mm, the head sagittal arc is 348.8-362.4 mm, the inter-tragus arc is 320-329.6 mm, and the head height is 206-210.7 mm.
9. The headform of claim 8, wherein, The structure parameters of the reference head model specifically include: the head circumference is 536.7 mm, the head length is 184 mm, and the head width is 152 mm.
10. The headform of any of claims 1-3, wherein, 11. The headform of any of claims 1-3, wherein, The head width and the head length in the structure parameters of the reference headform are determined based on the mean of the P50 parameter values of the head width and the head length of females in the age range of 61-70 years old and the P50 parameter values of the head width and the head length of males in the age range of 61-70 years old.
12. The headform of any of claims 1-3, wherein, The headform is further marked with one or more of an outer visible total separation line, a first separation line, a second separation line, a third separation line, a fourth separation line, and a fifth separation line, wherein: The total separation line passes through the glabella point of the headform, along the superciliary arch, through the preauricular points on both sides, and converges backward through the inion and between the electrode positions O1, OZ and O2 of the 10-10 international standard lead system; The first separation line passes through between the electrode positions F7 and FT7, between the electrode positions F5 and FC5, between the electrode positions FC3 and C3, between the electrode positions FC1 and C1, between the electrode positions FCZ and CZ, between the electrode positions FC2 and C2, between the electrode positions FC4 and C4, between the electrode positions F6 and FC6, and between the electrode positions F8 and FT8 of the 10-10 international standard lead system in sequence; The second separation line passes through between the electrode positions FC3 and C3, between the electrode positions FC1 and C1, between the electrode positions FCZ and CZ, between the electrode positions FC2 and C2, between the electrode positions FC4 and C4, between the electrode positions C6 and C4, between the electrode positions CP6 and CP4, between the electrode positions P6 and P4, between the electrode positions PO4 and P4, between the electrode positions PO4 and P2, between the electrode positions POZ and P2, between the electrode positions POZ and PZ, between the electrode positions POZ and P1, between the electrode positions PO3 and P1, between the electrode positions PO3 and P3, between the electrode positions P5 and P3, between the electrode positions CP5 and CP3, and between the electrode positions C5 and C3 of the 10-10 international standard lead system in sequence; The third separation line passes through between the electrode positions FT7 and F7, between the electrode positions FC5 and F5, between the electrode positions FC5 and FC3, between the electrode positions C5 and C3, between the electrode positions CP5 and CP3, between the electrode positions P5 and P3, between the electrode positions P5 and PO5, between the electrode positions P7 and PO7 of the 10-10 international standard lead system in sequence; The fourth separation line passes through between the electrode positions FT8 and F8, between the electrode positions FC6 and F6, between the electrode positions FC6 and FC4, between the electrode positions C6 and C4, between the electrode positions CP6 and CP4, between the electrode positions P6 and P4, between the electrode positions P6 and PO6, between the electrode positions P8 and PO8 of the 10-10 international standard lead system in sequence; The fifth partition line passes through between electrode positions P7 and PO7, between electrode positions P5 and PO5, between electrode positions P3 and PO3, between electrode positions P1 and POZ, between electrode positions PZ and POZ, between electrode positions P2 and POZ, between electrode positions P4 and PO4, between electrode positions P6 and PO6, and between electrode positions P8 and PO8 in the 10-10 international standard electrode system in order.
13. The headform of claim 12, wherein, The total partition line, the first partition line, the second partition line, the third partition line, the fourth partition line, and the fifth partition line are configured to satisfy one or more of the following conditions: An area enclosed by the first partition line and the total partition line corresponds to a front upper portion of the near-infrared light treatment subject; An area enclosed by the second partition line corresponds to a top portion of the near-infrared light treatment subject; An area enclosed by the third partition line and the total partition line corresponds to a left portion of the near-infrared light treatment subject; An area enclosed by the fourth partition line and the total partition line corresponds to a right portion of the near-infrared light treatment subject; An area enclosed by the fifth partition line and the total partition line corresponds to a rear portion of the near-infrared light treatment subject.