Tumor immune microenvironment detection and analysis device

Abstract

The utility model relates to the technical field of detection and analysis devices, in particular to a tumor immune microenvironment detection and analysis device which comprises a base, a detection light source, a detection groove and a spectrum receiving assembly. The detection groove is fixedly installed between the detection light source and the spectrum receiving assembly, a first adjusting frame is fixedly installed at the right end of the top of the base, the spectrum receiving assembly is fixedly installed at the top end of the first adjusting frame, a rotating column is rotationally connected to the front end of the base, and a second adjusting frame is fixedly installed at the top end of the rotating column. A cleaning cover is fixedly mounted at the top end of the second adjusting frame, a water guide ring is fixedly mounted on the inner side of the cleaning cover, and a plurality of groups of rotary spraying mechanisms are mounted at the bottom of the water guide ring. And the detection accuracy is improved.

Description

Technical Field

[0001] This utility model relates to the field of detection and analysis device technology, specifically to a tumor immune microenvironment detection and analysis device. Background Technology

[0002] When diagnosing cancer patients, immune testing is required. Immunoassay analyzers are various detection and analysis devices based on the principle of specific immune responses. They are widely used in the life sciences field. Immunoassay analyzers are instruments used to determine specific molecules in samples such as body fluids, serum, plasma, and whole blood. They generally include steps such as sample introduction, mixing, temperature control, reaction, cleaning, display, and detection and analysis.

[0003] In the cleaning process of immunoassay analyzers, fluid samples are placed in the detection tank and analyzed by spectroscopy. To improve detection accuracy, the inside of the detection tank needs to be washed after each test to remove the sample inside, so that it can be used for the next test. To ensure detection sensitivity, the ideal washing effect is to wash thoroughly and remove the least amount of sample residue.

[0004] A search revealed CN215066121 U, a device for detecting and analyzing the immune microenvironment of solid tumors. This device involves sliding a spectral receiving plate assembly onto a vertical plate, with a bracket fixedly mounted on a rotating column. A cleaning sealing cover is longitudinally slidably mounted on the bracket, with its rotation plane always positioned between the detection tank and the spectral receiving plate assembly. This allows for position adjustment of the cleaning sealing cover and pressurized spraying of the detection tank. After cleaning, the cleaning sealing cover separates from the detection tank and rotates to make way, thus not affecting detection, further reducing sample residue and improving detection accuracy. However, because the nozzle is fixed and the water flow direction is always downward, in actual use, when the cleaning sealing cover is closed, the water flow impact can easily spray sample residue from the detection tank onto the top of the cleaning sealing cover and the connection between the cleaning sealing cover and the detection tank. Since the nozzle can only spray downwards, sample residue may drip back down after the cleaning sealing cover is opened, resulting in incomplete cleaning and reduced detection accuracy.

[0005] Therefore, it is of great importance to design a tumor immune microenvironment detection and analysis device to address the above-mentioned shortcomings. Utility Model Content

[0006] To address the shortcomings of existing technologies, this invention presents a tumor immune microenvironment detection and analysis device. This device aims to solve the technical problem that existing solid tumor immune microenvironment detection and analysis devices, when cleaning the detection tank, suffer from incomplete cleaning due to the fixed nozzle and the always downward water flow, thus reducing the accuracy of detection.

[0007] To achieve the above objectives, this utility model provides the following technical solution:

[0008] A tumor immune microenvironment detection and analysis device includes a base, a detection light source, a detection tank, and a spectral receiving component. The detection light source is fixedly installed on the top of the base and directly below the spectral receiving component. The detection tank is fixedly installed between the detection light source and the spectral receiving component. A first adjustment frame is fixedly installed on the right end of the top of the base. The spectral receiving component is fixedly installed on the top of the first adjustment frame. A rotating column is rotatably connected to the front end of the base. A second adjustment frame is fixedly installed on the top of the rotating column. A cleaning hood is fixedly installed on the top of the second adjustment frame. A water guiding ring is fixedly installed on the inner side of the cleaning hood. Multiple sets of rotary spray mechanisms are installed at the bottom of the water guiding ring.

[0009] The rotary spray mechanism includes a connector threaded to the bottom of the water guide ring, a rotating head rotatably connected to the bottom end of the connector, a rotary spray pipe threaded to the bottom end of the rotating head, and multiple sets of spray hoses embedded inside the rotary spray pipe.

[0010] As a preferred embodiment of this utility model, the connector is rotatably connected to a rotating shaft inside, an impeller is fixedly installed on the outer side of the rotating shaft, a drive gear is fixedly connected to one end of the rotating shaft located on the outer side of the connector, and the outer side of the top of the rotating head meshes with the drive gear through a gear ring.

[0011] As a preferred embodiment of this utility model, a sealing ring is provided at the connection between the top of the rotary nozzle and the rotating head, and a shrinkage groove is provided inside the rotary nozzle at the position corresponding to the multiple sets of water spray hoses. The bottom ends of the inner sides of the multiple sets of water spray hoses are fixedly connected to the rotary nozzle by springs.

[0012] As a preferred embodiment of this utility model, the bottom end of the swirl spray pipe is provided with a lower spray port, the outer side of the multiple sets of water spray hoses is provided with multiple sets of side spray ports, and the top end of the multiple sets of water spray hoses is provided with an upper spray port.

[0013] As a preferred embodiment of this utility model, a lead screw is rotatably connected to the inner side of both the first and second adjustment frames, a motor is fixedly installed on the top of both the first and second adjustment frames, the top end of the lead screw is fixedly connected to the output end of the motor, a slide block is slidably connected to the inner side of both the first and second adjustment frames, and the slide block is threadedly connected to the lead screw, the spectral receiving component is fixedly connected to the slide block through a first connecting plate, and the cleaning cover is fixedly connected to the slide block through a second connecting plate.

[0014] As a preferred embodiment of this utility model, the first adjustment frame and the second adjustment frame are provided with sliding grooves on the left and right sides of the slide block, and the left and right ends of the slide block are slidably connected to the sliding grooves.

[0015] As a preferred embodiment of this utility model, the detection tank is fixedly connected to the outside of the first adjustment frame through the third connecting plate, a drain pipe is provided at the bottom of the outside of the detection tank, and a water inlet pipe is fixedly installed on the outside of the water guide ring and on the outside of the cleaning cover. Valves are installed on both the drain pipe and the water inlet pipe.

[0016] Compared with the prior art, the beneficial effects of this utility model are:

[0017] In this invention, through the coordinated design of the water guide ring and the rotary spray mechanism, when cleaning the inside of the testing tank, the cleaning cover is first placed on top of the testing tank, and then high-pressure water is introduced into the inside of the water guide ring. After the water enters the inside of the water guide ring, it is then introduced into the inside of multiple sets of connectors for diversion, and finally sprayed out through multiple sets of rotary spray pipes and water spray hoses. The power of the water flow drives the rotary spray pipes and multiple sets of water spray hoses to rotate and spray the testing tank, avoiding sample residue on the inside of the cleaning cover or the testing tank, thus fully completing the cleaning and improving the accuracy of the test. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0019] Figure 2 This is a schematic diagram of the water guide ring and swirl jet mechanism of this utility model;

[0020] Figure 3 This is a schematic diagram of the rotary spray mechanism of this utility model;

[0021] Figure 4 This is a schematic diagram of the internal structure of the connector of this utility model;

[0022] Figure 5 This is a schematic diagram of the internal structure of the swirl nozzle and water spray hose of this utility model.

[0023] In the diagram: 1. Base; 2. Detection light source; 3. Detection groove; 301. Third connecting plate; 302. Drain pipe; 4. Spectrum receiving component; 5. First adjusting frame; 501. Lead screw; 502. Motor; 503. Slide; 504. First connecting plate; 505. Second connecting plate; 506. Slide groove; 6. Rotating column; 7. Second adjusting frame; 8. Cleaning hood; 9. Water guide ring; 901. Water inlet pipe; 902. Valve; 10. Spraying mechanism; 1001. Connector; 1002. Rotating head; 1003. Spraying pipe; 1004. Water spray hose; 1005. Rotating shaft; 1006. Impeller; 1007. Drive gear; 1008. Gear ring; 1009. Sealing ring; 1010. Shrinkage groove; 1011. Spring; 1012. Lower nozzle; 1013. Side nozzle; 1014. Upper nozzle. Detailed Implementation

[0024] The technical solutions of the present utility model will be clearly and completely described below with reference to the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present utility model without creative effort are within the protection scope of the present utility model.

[0025] Example:

[0026] Please see Figures 1-5 This utility model provides a technical solution:

[0027] A tumor immune microenvironment detection and analysis device includes a base 1, a detection light source 2, a detection slot 3, and a spectral receiving component 4. The detection light source 2 is fixedly installed on the top of the base 1 and located directly below the spectral receiving component 4. The detection slot 3 is fixedly installed between the detection light source 2 and the spectral receiving component 4. A first adjustment frame 5 is fixedly installed on the right end of the top of the base 1. The spectral receiving component 4 is fixedly installed on the top of the first adjustment frame 5. A rotating column 6 is rotatably connected to the front end of the base 1. A second adjustment frame 7 is fixedly installed on the top of the rotating column 6. A cleaning hood 8 is fixedly installed on the top of the second adjustment frame 7. A water guiding ring 9 is fixedly installed on the inner side of the cleaning hood 8. Multiple sets of rotary spray mechanisms 10 are installed at the bottom of the water guiding ring 9.

[0028] First, in this embodiment, the specific structure of the rotary spraying mechanism 10 is as follows:

[0029] The rotary spray mechanism 10 includes a connector 1001 threaded to the bottom of the water guide ring 9. A rotating head 1002 is rotatably connected to the bottom end of the connector 1001. A rotary spray pipe 1003 is threaded to the bottom end of the rotating head 1002. Multiple sets of water spray hoses 1004 are embedded inside the rotary spray pipe 1003. When cleaning the inside of the test tank 3, the cleaning cover 8 is first placed on the top of the test tank 3. Then, high-pressure water is introduced into the inside of the water guide ring 9. After the water enters the inside of the water guide ring 9, it is then introduced into the inside of the multiple sets of connectors 1001 for diversion. Finally, it is sprayed out through the multiple sets of rotary spray pipes 1003 and water spray hoses 1004, thereby cleaning the inside of the test tank 3.

[0030] Furthermore, a rotating shaft 1005 is rotatably connected inside the connector 1001, and an impeller 1006 is fixedly installed on the outside of the rotating shaft 1005. A drive gear 1007 is fixedly connected to one end of the rotating shaft 1005 located outside the connector 1001. The outer side of the top of the rotating head 1002 meshes with the drive gear 1007 through a gear ring 1008. After the high-pressure water flow enters the interior of the connector 1001, the rotating shaft 1005 is driven to rotate under the action of the impeller 1006. Subsequently, the rotating head 1002 is driven to rotate under the transmission of the drive gear 1007 and the gear ring 1008, thereby driving the rotary spray pipe 1003 and multiple sets of water spray hoses 1004 to rotate and spray the detection tank 3, avoiding sample residues in the cleaning hood 8 or the inside of the detection tank 3, thus thoroughly cleaning the inside of the detection tank 3 and improving the accuracy of the detection.

[0031] Then, a sealing ring 1009 is fitted at the connection between the top of the spray nozzle 1003 and the rotating head 1002. A shrinkage groove 1010 is provided inside the spray nozzle 1003 at the corresponding positions of the multiple sets of water spray hoses 1004. The bottom ends of the inner sides of the multiple sets of water spray hoses 1004 are fixedly connected to the spray nozzle 1003 by springs 1011. After the bottom end of the rotating head 1002 is connected to the spray nozzle 1003, the sealing ring 1009 ensures the sealing of the connection. When the spray nozzle 1003 rotates, the multiple sets of water spray hoses 1004 are ejected from the inside of the shrinkage groove 1010 under the action of centrifugal force. At the same time, under the connection of the springs 1011, the multiple sets of water spray hoses 1004 are always in an inclined state, thereby expanding the spray range and fully cleaning the inside of the detection tank 3.

[0032] Furthermore, the bottom end of the rotary nozzle 1003 is provided with a lower nozzle 1012, and the outer sides of the multiple sets of water spray hoses 1004 are provided with multiple sets of side nozzles 1013. The top end of the multiple sets of water spray hoses 1004 is provided with an upper nozzle 1014. When water flows into the interior of the rotary nozzle 1003, it can spray and wash the bottom end of the detection tank 3 downward through the lower nozzle 1012. When the side nozzles 1013 on the outer side of the water spray hoses 1004 rotate, they can fully spray and wash the inner walls of the detection tank 3 and the cleaning hood 8. The upper nozzle 1014 can spray and wash the top of the cleaning hood 8 upward, thereby spraying and washing all parts of the cleaning hood 8 and the interior of the detection tank 3, avoiding sample residue in the cleaning hood 8 or the interior of the detection tank 3, thus fully completing the cleaning and improving the accuracy of the detection.

[0033] The first adjusting frame 5 and the second adjusting frame 7 are rotatably connected to the inner sides of a lead screw 501. A motor 502 is fixedly installed on the top of the first adjusting frame 5 and the second adjusting frame 7. The top end of the lead screw 501 is fixedly connected to the output end of the motor 502. A slide block 503 is slidably connected to the inner sides of the first adjusting frame 5 and the second adjusting frame 7. The slide block 503 is threadedly connected to the lead screw 501. The spectral receiving component 4 is fixedly connected to the slide block 503 through a first connecting plate 504. The cleaning cover 8 is fixedly connected to the slide block 503 through a second connecting plate 505. The motor 502 drives the lead screw 501 to rotate, which drives the slide block 503 to slide up and down on the inner sides of the first adjusting frame 5 and the second adjusting frame 7, thereby moving the spectral receiving component 4 and the cleaning cover 8 up and down.

[0034] Secondly, the first adjusting frame 5 and the second adjusting frame 7 are provided with sliding grooves 506 on the left and right sides of the slide block 503. The left and right ends of the slide block 503 are slidably connected to the sliding grooves 506. When the slide block 503 moves, its movement stability is improved by the sliding grooves 506.

[0035] Finally, the detection tank 3 is fixedly connected to the outside of the first adjusting frame 5 through the third connecting plate 301. A drain pipe 302 is provided at the bottom of the outside of the detection tank 3. An inlet pipe 901 is fixedly installed on the outside of the water guide ring 9 and on the outside of the cleaning cover 8. Valves 902 are installed on both the drain pipe 302 and the inlet pipe 901. High-pressure water is introduced through the inlet pipe 901 to clean the inside of the cleaning cover 8 and the detection tank 3. After cleaning, the drain pipe 302 is opened to discharge wastewater.

[0036] In this embodiment, the specific implementation scenario is as follows: When cleaning the inside of the detection tank 3, the cleaning cover 8 is first placed on top of the detection tank 3, and then high-pressure water is introduced into the inside of the water guide ring 9. After the water enters the inside of the water guide ring 9, it is then introduced into the inside of the multiple sets of connectors 1001 for diversion. Under the action of the impeller 1006, the rotating shaft 1005 is driven to rotate. Then, under the transmission of the drive gear 1007 and the gear ring 1008, the rotating head 1002 is driven to rotate, thereby driving the vortex spray pipe 1003 and the multiple sets of water spray hoses 1004 to rotate and spray the detection tank 3. When the vortex spray pipe 1003 rotates, the multiple sets of water spray hoses 1004 are ejected from the inside of the shrinkage tank 1010 under the action of centrifugal force. At the same time, under the connection of the spring 1011, the multiple sets of water spray hoses 1004 are ejected from the inside of the shrinkage tank 1010. The 04 nozzle is always tilted, thus expanding the spray range to thoroughly clean the inside of the detection tank 3. After the water flow is introduced into the interior of the vortex spray pipe 1003, the bottom of the detection tank 3 can be sprayed downwards through the lower nozzle 1012. The side nozzle 1013 on the outside of the water spray hose 1004 can thoroughly spray the inner walls of the detection tank 3 and the cleaning hood 8 when rotating, while the upper nozzle 1014 can spray upwards to clean the top of the cleaning hood 8. This ensures that the cleaning hood 8 and the inside of the detection tank 3 are cleaned, preventing sample residue from remaining in the cleaning hood 8 or the inside of the detection tank 3. The entire operation process is simple and convenient. Compared with existing tumor immune microenvironment detection and analysis devices, this utility model can fully complete the cleaning and avoid sample residue through its design, thus improving the accuracy of the detection.

[0037] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A tumor immune microenvironment detection and analysis device, comprising a base (1), a detection light source (2), a detection slot (3), and a spectral receiving component (4), characterized in that: The detection light source (2) is fixedly installed on the top of the base (1) and located directly below the spectral receiving component (4). The detection slot (3) is fixedly installed between the detection light source (2) and the spectral receiving component (4). A first adjustment frame (5) is fixedly installed on the right end of the top of the base (1). The spectral receiving component (4) is fixedly installed on the top of the first adjustment frame (5). A rotating column (6) is rotatably connected to the front end of the base (1). A second adjustment frame (7) is fixedly installed on the top of the rotating column (6). A cleaning cover (8) is fixedly installed on the top of the second adjustment frame (7). A water guide ring (9) is fixedly installed on the inner side of the cleaning cover (8). Multiple sets of rotary spray mechanisms (10) are installed at the bottom of the water guide ring (9). The rotary spray mechanism (10) includes a connector (1001) threaded to the bottom of the water guide ring (9), a rotating head (1002) rotatably connected to the bottom end of the connector (1001), a rotary spray pipe (1003) threaded to the bottom end of the rotating head (1002), and multiple sets of water spray hoses (1004) embedded inside the rotary spray pipe (1003).

2. The tumor immune microenvironment detection and analysis device according to claim 1, characterized in that: The connector (1001) is rotatably connected to a rotating shaft (1005). An impeller (1006) is fixedly installed on the outer side of the rotating shaft (1005). A drive gear (1007) is fixedly connected to one end of the rotating shaft (1005) located on the outer side of the connector (1001). The outer side of the top of the rotating head (1002) meshes with the drive gear (1007) through a gear ring (1008).

3. The tumor immune microenvironment detection and analysis device according to claim 1, characterized in that: A sealing ring (1009) is fitted at the connection between the top of the spray pipe (1003) and the rotating head (1002). A shrinkage groove (1010) is provided inside the spray pipe (1003) at a position corresponding to the multiple sets of water spray hoses (1004). The bottom ends of the inner sides of the multiple sets of water spray hoses (1004) are fixedly connected to the spray pipe (1003) by springs (1011).

4. The tumor immune microenvironment detection and analysis device according to claim 1, characterized in that: The bottom end of the rotary nozzle (1003) is provided with a lower nozzle (1012), and the outer side of the multiple sets of water spray hoses (1004) is provided with multiple sets of side nozzles (1013). The top end of the multiple sets of water spray hoses (1004) is provided with an upper nozzle (1014).

5. The tumor immune microenvironment detection and analysis device according to claim 1, characterized in that: Both the first adjusting frame (5) and the second adjusting frame (7) are rotatably connected to a lead screw (501). Both the first adjusting frame (5) and the second adjusting frame (7) are fixedly mounted with a motor (502). The top end of the lead screw (501) is fixedly connected to the output end of the motor (502). Both the first adjusting frame (5) and the second adjusting frame (7) are slidably connected to a slide block (503). The slide block (503) is threadedly connected to the lead screw (501). The spectral receiving component (4) is fixedly connected to the slide block (503) through a first connecting plate (504). The cleaning cover (8) is fixedly connected to the slide block (503) through a second connecting plate (505).

6. The tumor immune microenvironment detection and analysis device according to claim 5, characterized in that: The first adjusting frame (5) and the second adjusting frame (7) are provided with sliding grooves (506) on the left and right sides of the slide block (503), and the left and right ends of the slide block (503) are slidably connected to the sliding grooves (506).

7. The tumor immune microenvironment detection and analysis device according to claim 1, characterized in that: The detection tank (3) is fixedly connected to the outside of the first adjustment frame (5) via the third connecting plate (301). A drain pipe (302) is provided at the bottom of the outside of the detection tank (3). An inlet pipe (901) is fixedly installed on the outside of the water guide ring (9) and on the outside of the cleaning cover (8). Valves (902) are installed on both the drain pipe (302) and the inlet pipe (901).

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