Oral concentrated solvent dissolving equipment

Abstract

The utility model aims to provide oral concentrated solvent dissolving equipment which comprises a tank body, a partition plate is arranged in the tank body and divides an inner cavity of the tank body into an upper cavity body and a lower cavity body, and a through hole is formed in the partition plate and enables the upper cavity body to be communicated with the lower cavity body; a pipeline for communicating the upper cavity with the lower cavity is arranged on one side of the tank body, and a pump is arranged on the pipeline. The utility model relates to the technical field of liquid medicine preparation equipment, and adopts a step-by-step dissolution mode to primarily dissolve medicine powder in an upper cavity by using a small amount of hot purified water to form a concentrated solution. Then, the concentrated solution is put into the lower cavity to be mixed and stirred with a large amount of purified water, and the stirred liquid in the lower cavity is continuously sucked to the upper cavity, so that the concentrated solution flows in the equipment through a pipeline, is uniformly distributed through a partition plate and drips and flows back through a through pipe; the contact between solute and solvent is greatly increased through the multi-form flow path, and the overall dissolution rate is increased.

Description

Technical Field

[0001] This utility model relates to the technical field of pharmaceutical preparation equipment, specifically an oral concentrated solvent dissolution device. Background Technology

[0002] The preparation process of oral concentrated solvents (such as sodium potassium magnesium sulfate oral concentrated solvent) typically includes steps such as solution preparation, pH adjustment, volume adjustment, and filtration. Among these, the solution preparation stage is a critical step. This stage usually involves adding the drug powder and solvent to a preparation tank, mixing with purified water, and then heating and stirring to promote dissolution. According to current process requirements, this stirring and dissolution process often needs to last 30 to 40 minutes to ensure that the drug powder is completely dissolved in the purified water to form a homogeneous solution. However, traditional stirred tanks have relatively low dissolution efficiency when processing drug powders. This is mainly because the contact area between the powder particles and the solvent is limited, and under conventional stirring conditions, the dispersion and dissolution rate of the particles is slow, especially when processing drug powders with multiple components or high concentrations. This low dissolution rate leads to a long solution preparation stage, reducing overall production efficiency. Therefore, there is an urgent need in existing technologies to improve the dissolution efficiency of the oral concentrated solvent preparation stage and shorten the dissolution time. Utility Model Content

[0003] To address the shortcomings of existing technologies, this invention provides an oral concentrated solvent dissolution device that solves the problem of low stirring and dissolution efficiency in the preparation stage of existing oral concentrated solvents.

[0004] To achieve the above objectives, this utility model provides the following technical solution: an oral concentrated solvent dissolution device, comprising a tank, an injection pipe and a stirrer inserted into the tank, a stirring paddle at the bottom of the stirrer, a partition inside the tank dividing the inner cavity into an upper cavity and a lower cavity, a through hole in the partition connecting the upper cavity and the lower cavity; a pipe connecting the upper cavity and the lower cavity is provided on one side of the tank, and a pump is installed on the pipe.

[0005] Preferably, the stirring paddle includes a main stirring paddle and an auxiliary stirring paddle, with the auxiliary stirring paddle located in the upper cavity and the main stirring paddle located in the lower cavity.

[0006] Preferably, the upper surface of the partition plate is provided with multiple protruding ridges, and a gap groove is formed between two adjacent protruding ridges.

[0007] Preferably, the protruding ridges are strip-shaped and arranged in a circular array on the partition plate with the main shaft of the stirrer as the axis.

[0008] Preferably, the auxiliary stirring paddle is located above the convex ridge.

[0009] Preferably, the inner top of the lower cavity is provided with a plurality of side support plates supporting the partition, and a guide fluid is provided between two adjacent side support plates, the wall of the guide fluid being arc-shaped.

[0010] Preferably, the bottom of the arc-shaped inner wall of the fluid guide is tangent to the inner wall of the tank, and the top is tangent to the bottom surface of the partition.

[0011] Preferably, the through holes and pipes are located on both sides of the tank body under the orthographic projection of the tank body.

[0012] Preferably, an auxiliary heater is provided at the bottom of the partition.

[0013] Preferably, a through pipe is provided inside the through hole, the top of the through pipe being flush with or lower than the top surface of the through hole, and the bottom extending into the lower cavity.

[0014] Beneficial effects

[0015] By using the oral concentrated solvent dissolution device provided by this utility model, a stepwise dissolution method is adopted. The drug powder is first initially dissolved in a small amount of hot purified water in the upper chamber to form a concentrated solution. Subsequently, this concentrated solution is added to the lower chamber and mixed with a large amount of purified water. The stirred liquid in the lower chamber is continuously drawn into the upper chamber, allowing the concentrated solution to flow through pipes, be evenly distributed by baffles, and drip back through a connecting pipe. These multiple flow paths greatly increase the contact between the solute and solvent, improving the overall dissolution rate. During stirring and circulation, incompletely dissolved particles collide with the protrusions on the inner wall of the chamber or collide with each other in the gaps, helping to break up particle aggregation, reduce particle size, and accelerate the dissolution process, further improving the overall dissolution rate. Attached Figure Description

[0016] Figure 1 This is a front view of the tank body of this utility model;

[0017] Figure 2 This utility model Figure 1 AA projection diagram;

[0018] Figure 3 This utility model Figure 1 BB projection diagram;

[0019] Figure 4 This is a schematic diagram of the fluid guiding structure of this utility model;

[0020] Figure 5 This is a diagram showing the liquid flow path inside the tank of this utility model.

[0021] Explanation of symbols in the diagram:

[0022] 1. Tank body, 2. Agitator, 3. Auxiliary agitator, 4. Main agitator, 5. Baffle, 6. Upper cavity, 7. Lower cavity, 8. Injection pipe, 9. Auxiliary heater, 10. Through pipe, 11. Fluid guide, 12. Side support plate, 13. Pump, 14. Pipe, 15. Rib, 16. Gap groove. Detailed Implementation

[0023] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Various changes can be made to the implementation scheme as long as the effects of the present invention can be achieved.

[0024] Those skilled in the art can connect the components in this case sequentially. The specific connection and operation sequence should refer to the working principle described below. The detailed connection methods are well-known technologies in the field. The following mainly introduces the working principle and process.

[0025] Reference Figure 1-5 An oral concentrated solvent dissolution device according to this embodiment includes a tank 1, on which an injection pipe 8 is provided and a stirrer 2 inserted into the tank 1. A stirring paddle is provided at the bottom of the stirrer 2. There may be multiple injection pipes 8, which are used to add purified water, drug powder (such as sodium sulfate, potassium sulfate and magnesium sulfate, etc.), drug solvent (such as flavoring agents and benzoic acid, etc.) and excipients such as preservatives and pH adjusters into the tank 1.

[0026] Furthermore, such as Figure 1 As shown, tank 1 is a vertical stirring tank with an internal partition 5 dividing the inner cavity of tank 1 into an upper cavity 6 and a lower cavity 7 arranged vertically. The partition 5 has a through-hole allowing the upper cavity 6 and lower cavity 7 to communicate. A pipe 14 connecting the upper cavity 6 and lower cavity 7 is located on one side of tank 1, and a pump 13 is installed on the pipe 14. Pump 13 draws heated purified water from the lower cavity 7 into the upper cavity 6, where it is initially mixed with the drug powder added to the upper cavity 6. The water then flows through the through-hole into the lower cavity 7 for further stirring and mixing, allowing the powder to dissolve in a smaller amount of heated purified water to obtain a concentrated solution. This concentrated solution is then added to pure water for further stirring, increasing the dissolution rate of the powder. Simultaneously, during stirring, pump 13 continuously draws the stirred liquid into the upper cavity 6, and then returns it to the lower cavity 7, forming a water circulation.

[0027] Furthermore, in this embodiment, an auxiliary heater 9 is provided at the bottom of the partition 5. The auxiliary heater 9 is a resistance wire heater, which heats and replenishes the temperature of the partition 5 and the upper cavity 6, so that the hot purified water in the upper cavity 6 can be maintained between 75°C and 85°C. At the same time, the temperature released by the auxiliary heater 9 acts on the partition 5, raising the temperature of the powder to be dissolved and accelerating the dissolution rate of the powder.

[0028] In another embodiment, the partition 5 is double-layered (not shown in the figure) with a cavity in the middle, and the auxiliary heater 9 can be placed in the cavity to improve the thermal conductivity.

[0029] In this embodiment, a through pipe 10 is provided inside the through hole, and a solenoid valve is installed inside the through pipe 10. When installing, the top of the through pipe 10 needs to be flush with or lower than the top surface of the through hole to ensure that the liquid in the upper cavity 6 can enter the through pipe 10, and the bottom of the through pipe 10 extends into the lower cavity 7.

[0030] Furthermore, under the orthographic projection of tank 1, through holes and pipes 14 are respectively located on both sides of tank 1. During the water circulation phase, such as... Figure 5 As shown, the concentrated solution prepared in the lower chamber 7 enters the upper chamber 6 through the pipe 14. After flowing over the surface of the partition 5, it flows back to the lower chamber 7 through the connecting pipe 10 on the other side, forming a water circulation. This allows the concentrated solution (before filtration) to flow through the pipe 14, be evenly distributed by the partition 5, and drip back through the connecting pipe 10. It is then stirred by the stirring paddle in the upper chamber 6 and the lower chamber 7, so that the drug powder and drug solvent are completely dissolved in the purified water.

[0031] In this embodiment, the stirring paddle includes a main stirring paddle 4 and an auxiliary stirring paddle 3, wherein the auxiliary stirring paddle 3 is located in the upper cavity 6 and the main stirring paddle 4 is located in the lower cavity 7, and the liquids in the upper cavity 6 and the lower cavity 7 are stirred and fused respectively.

[0032] like Figure 1 and Figure 2 As shown, the upper surface of the partition 5 is provided with multiple protruding ribs 15, and a gap groove 16 is formed between two adjacent protruding ribs 15. In one arrangement of the protruding ribs 15, the protruding ribs 15 are strip-shaped and arranged in a circular array on the partition 5 with the main shaft of the stirrer as the axis. The auxiliary stirring paddle 3 is located above the protruding ribs 15.

[0033] When the drug powder is added, the drug powder and high-temperature purified water in the upper cavity 6 rotate at high speed under the influence of the auxiliary stirring paddle 3. The particulate matter precipitated by the powder acts on the protrusion 15 and the gap groove 16, impacting the protrusion 15 or colliding with each other in the gap groove 16, so as to improve the dissolution rate of particulate matter in the drug powder.

[0034] At the same time, such as Figure 1 and Figures 3 to 5As shown, in the lower cavity 7 of this embodiment, multiple side support plates 12 for supporting the partition 5 are arranged circumferentially at the top. A guide fluid 11 is arranged between two adjacent side support plates 12, and the wall surface of the guide fluid 11 is arc-shaped. The bottom of the arc-shaped inner wall surface of the guide fluid 11 is tangent to the inner wall of the tank 1, and the top is tangent to the bottom surface of the partition 5. When the solution in the lower cavity 7 is stirred by the main stirring paddle 4, the solution floats to the outside of the lower cavity 7 and is guided down from the middle (circumferentially close to the stirrer 2) to form an internal circulation in the lower cavity 7. When the solution floats to the top on the outside of the lower cavity 7, it contacts the arc-shaped inner wall surface of the guide fluid 11, directly guiding the solution to the main shaft of the stirrer 2, avoiding irregular movement of the solution after floating, improving the flow smoothness of the solution in the lower cavity 7, thereby improving the stirring and dissolution rate.

[0035] Furthermore, this embodiment also discloses a method for preparing sodium potassium magnesium sulfate oral concentrated solvent using the above-mentioned oral concentrated solvent dissolution device. The method includes: S1, adding purified water into the lower chamber 7 through the upper chamber 6 and heating it to 80°C, then drawing the heated purified water into the upper chamber 6, adding the drug powder and stirring for 8 minutes; S2, introducing the solution obtained in S1 into the lower chamber 7 through the connecting pipe 10, mixing it with the remaining high-temperature purified water and stirring for 5 minutes; S3, turning on the pump 13 and opening the solenoid valve to allow the lower chamber to... S7. The stirred solution is circulated through pipe 14, upper chamber 6 and connecting pipe 10 for 10 minutes to obtain solution A; S4. Add drug solvent and preservative to obtain solution B; S5. Adjust the pH of the solution to 3.4; S6. Heat to 95°C and maintain for 30 minutes, then cool down to less than 30°C, turn on pump 13 again and open solenoid valve to circulate the stirred solution in lower chamber 7 through pipe 14, upper chamber 6 and connecting pipe 10 for 10 minutes; S7. Filter the solution obtained in S6 and fill it.

[0036] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. An oral concentrated solvent dissolving device comprising a tank body, an injection pipe is arranged on the tank body, and a stirrer is inserted into the inside of the tank body, a stirring paddle is arranged at the bottom of the stirrer, characterized in that: The tank body is equipped with a partition that divides the inner cavity of the tank body into an upper cavity and a lower cavity. The partition has a through hole that allows the upper cavity and the lower cavity to communicate with each other. A pipe connecting the upper and lower chambers is provided on one side of the tank, and a pump is installed on the pipe.

2. An oral dense solvent dissolution device according to claim 1, wherein: The stirring paddle includes a main stirring paddle and an auxiliary stirring paddle, with the auxiliary stirring paddle located in the upper cavity and the main stirring paddle located in the lower cavity.

3. An oral concentrated solvent dissolving apparatus according to claim 1, wherein: The upper surface of the partition plate is provided with multiple protruding ridges, and a gap groove is formed between two adjacent protruding ridges.

4. An oral dense solvent dissolution device according to claim 3, wherein: The protruding ridges are strip-shaped and arranged in a circular array on the partition plate with the main shaft of the stirrer as the axis.

5. An oral dense solvent dissolution device according to claim 3, wherein: The auxiliary stirring paddle is located above the convex ridge.

6. An oral dense solvent dissolution device according to claim 1, wherein: The lower cavity has multiple side support plates circumferentially arranged at the top of the inner cavity to support the partition. A fluid guide is arranged between two adjacent side support plates, and the wall of the fluid guide is arc-shaped.

7. An oral dense solvent dissolution device according to claim 6, wherein: The bottom of the arc-shaped inner wall of the fluid guide is tangent to the inner wall of the tank, and the top is tangent to the bottom surface of the partition.

8. The oral dense solvent dissolution device of claim 1, wherein: Under the orthographic projection of the tank body, the through holes and pipes are located on both sides of the tank body.

9. The oral dense solvent dissolution device of claim 1, wherein: An auxiliary heater is provided at the bottom of the partition.

10. The oral dense solvent dissolution device of claim 1, wherein: A through pipe is provided inside the through hole. The top of the through pipe is flush with or lower than the top surface of the through hole, and the bottom extends into the lower cavity.

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