Antibacterial absorbable gentamicin-loaded silk fibroin medical rivet and mold

Abstract

The utility model relates to the technical field of medical rivets, and provides an antibacterial absorbable gentamicin-loaded silk fibroin medical rivet and a mold. The rivet rod of the rivet is provided with an inner hexagonal notch and a wire passing through hole, and the screw pitches of threads at the near end and the far end of the rivet are different, so that the fixing strength of the rivet in sclerotin can be enhanced; the material overcomes the defects that metal cannot be absorbed and polylactic acid is used as a material, and can be degraded in time, resist bacteria, reduce foreign body reaction and inflammation and promote tissue healing; and the internal structural design of the rivet can meet the use requirement of the rivet under an arthroscopic surgery. The personalized mold is suitable for the special preparation process of fibroin, a mold body is composed of an upper mold body and a lower mold body which are detachable, and a pouring cavity formed by butt joint of pouring grooves of the upper mold body and the lower mold body can precisely mold the appearance of a rivet; the inner core assembly comprises an inner hexagonal column, a circular column and a positioning seat, and the inner structure of the rivet can be accurately formed. And the rivet is integrally formed to avoid later processing, so that high standard and consistency of products are ensured. The mold is ingenious in overall matching, convenient to assemble, maintain and operate, and time-saving and labor-saving.

Description

Technical Field

[0001] This utility model relates to the field of medical rivet technology, specifically to an antibacterial and absorbable gentamicin-loaded silk fibroin medical rivet and its mold. Background Technology

[0002] Shoulder arthroscopy is a modern minimally invasive surgical technique used for the diagnosis and treatment of shoulder diseases. During the procedure, the surgeon makes several tiny incisions in the patient's shoulder, typically only a few millimeters in diameter, and then inserts a specially designed arthroscope into the joint cavity. The arthroscope, a sophisticated instrument equipped with a light source and a high-definition camera, acts like the surgeon's "eye" inside the shoulder joint, clearly transmitting real-time images of the joint's structures, such as cartilage, ligaments, and synovium, to an external display screen. Based on these images, the surgeon can precisely observe the lesion and determine the location and extent of the injury. Furthermore, through the tiny operating channels attached to the arthroscope, the surgeon can introduce various delicate surgical instruments, such as miniature scalpels, grasping forceps, and radiofrequency ablation needles, to perform a series of complex surgical procedures under direct arthroscopic visualization, such as cleaning damaged tissue, repairing torn ligaments, and removing loose bodies. This aims to alleviate shoulder pain, restore joint function, and improve the patient's quality of life. Compared to traditional open surgery, it has significant advantages such as less trauma, less bleeding, and faster postoperative recovery.

[0003] Within the scope of shoulder arthroscopy, rivet implantation is a common procedure. Currently, the main types of rivets available on the market are metal and polylactic acid (PLA). Metal rivets, due to their non-absorbable nature, are used less frequently in clinical practice. In contrast, PLA rivets have a wider range of applications; however, they also present several significant challenges. Firstly, PLA rivets can easily induce local inflammation after implantation, leading to increased skin temperature and often significant pain. Secondly, the absorption process of these rivets is extremely slow; generally, even after 2 to 3 years, complete absorption is difficult. More seriously, both metal and PLA rivets increase the risk of postoperative infection to varying degrees, adding numerous obstacles to the patient's recovery.

[0004] Furthermore, the humeral head of the shoulder joint has unique structural characteristics: a hard outer cortical bone and a loose inner cancellous bone. Current methods of fixation with rivets present specific challenges. If the rivet's threads are fine, while a relatively tight engagement with the hard outer cortical bone can be achieved to some extent, the stability of the connection with the inner cancellous bone is significantly compromised, making the rivet prone to being pulled out. Conversely, if the rivet's threads are sparse, the connection with the hard outer cortical bone will be significantly insufficient, making it difficult to ensure the stability and durability of the fixation, thus affecting the overall quality of the surgery and the patient's recovery. Utility Model Content

[0005] The purpose of this invention is to provide an antibacterial and absorbable gentamicin-loaded silk fibroin medical rivet and mold, aiming to solve the technical problems in the background art mentioned above.

[0006] The embodiments of this utility model are implemented as follows:

[0007] In a first aspect, embodiments of this application provide an antibacterial and absorbable gentamicin-loaded fibroin medical rivet, comprising a gentamicin-loaded fibroin-type rivet shank, wherein a first end face of the gentamicin-loaded fibroin-type rivet axially has an internal hexagonal notch, and the bottom of the internal hexagonal notch axially has two through holes, and one end of any of the through holes, away from the internal hexagonal notch, penetrates the second end face of the gentamicin-loaded fibroin-type rivet shank; wherein the outer circumferential surface of the gentamicin-loaded fibroin-type rivet shank is provided with an external thread, and the pitch of the external thread on the same side as the internal hexagonal notch is less than the pitch of the external thread on the same side as any of the through holes.

[0008] Furthermore, based on the aforementioned scheme, one end of the external thread is flush with the first end face of the gentamicin-loaded silk fibroin type nail rod, and the other end is spaced apart from the second end face of the gentamicin-loaded silk fibroin type nail rod.

[0009] In particular, along the direction from the first end face to the second end face of the gentamicin-loaded silk fibroin type nail rod, the diameter of the gentamicin-loaded silk fibroin type nail rod between the external thread and the second end face of the gentamicin-loaded silk fibroin type nail rod gradually decreases.

[0010] Secondly, this application provides a mold for manufacturing the traditional Chinese medicine rivets mentioned in the first aspect, comprising: a mold body including a detachably fitted upper mold and a lower mold, wherein the upper mold is provided with a first casting groove, the lower mold is provided with a second casting groove, and the lower mold is connected to the first casting groove to form a casting cavity, the outer contour of the casting cavity being the same as the outer contour of the gentamicin-loaded silk fibroin type rivet; wherein, both ends of the casting cavity respectively penetrate the outer side of the mold body on the same side; and a seal detachably fitted to the first port of the casting cavity. The body; and the inner core assembly, including an internal hexagonal prism, two circular prisms and a positioning seat, wherein the positioning seat is used for detachable engagement with the second port of the casting cavity, the internal hexagonal prism is disposed on the positioning seat, and the two circular prisms are disposed on the end face of the internal hexagonal prism away from the positioning seat, and the axis of any of the circular prisms is parallel to the axis of the internal hexagonal prism. When the positioning seat is engaged with the second port of the casting cavity, the internal hexagonal prism and the two circular prisms extend into the casting cavity, and the internal hexagonal prism is coaxial with the casting cavity.

[0011] Furthermore, based on the aforementioned scheme, the positioning seat is provided with multiple guide holes, and the axis of any of the guide holes is parallel to the axis of the internal hexagonal column.

[0012] Furthermore, based on the aforementioned scheme, the positioning seat, the internal hexagonal column, and the two circular columns constitute an integral molded structure.

[0013] Furthermore, based on the aforementioned scheme, the positioning seat includes an overlapping and coaxially arranged first circular platform and a second circular platform, wherein the diameter of the second circular platform is smaller than the diameter of the first circular platform.

[0014] The second port of the aforementioned casting cavity is circular and is adapted to the aforementioned second circular platform.

[0015] Furthermore, based on the aforementioned scheme, the upper mold and the lower mold are detachably connected by bolts.

[0016] Furthermore, based on the aforementioned scheme, the sealing body is a stud and is threadedly engaged with the first port of the casting cavity.

[0017] Compared with the prior art, the embodiments of this utility model have at least the following advantages or beneficial effects:

[0018] The antibacterial and absorbable gentamicin-loaded silk fibroin medical rivet provided in this application has significant advantages compared to traditional metal and polylactic acid materials. In terms of material, it eliminates the non-absorbability of metal, avoiding a series of potential problems that may arise from long-term metal retention in the body, such as foreign body reactions and interference with subsequent imaging examinations. It also overcomes the drawbacks of polylactic acid, such as slow absorption and a tendency to cause local inflammatory reactions. The gentamicin-loaded silk fibroin material not only degrades and is absorbed in the body in a timely manner, without causing long-term burden on the patient, but also possesses antibacterial properties due to the presence of gentamicin, effectively reducing the risk of postoperative infection and creating a favorable environment for wound healing. The differentiated setting of the external thread pitch at both ends when connecting to bone is also ingenious. This design allows the tightly threaded outer portion (with a smaller pitch) of the rivet to connect more firmly with the outer cortical bone after it is driven into the bone, while the looser threaded outer portion (with a larger pitch) reduces cutting into the cancellous bone as it penetrates deeper into the inner cancellous bone, increasing compression of the cancellous bone around the screw. On the other hand, the gentamicin-loaded silk fibroin screw will slightly expand after absorbing water, further strengthening the screw's holding force within the bone. The advantages of the rivet's structure and material properties ensure that it achieves firm and reliable fixation within the bone, making it less prone to loosening or being pulled out. This greatly improves the practicality and effectiveness of medical rivets in scenarios such as shoulder arthroscopic surgery.

[0019] The antibacterial and absorbable gentamicin-loaded fibroin medical rivet provided in this application has an internal hexagonal groove at the proximal end and two through holes at the distal end, which allow the sutures to slide inside the rivet, thus enabling it to be implanted and used in minimally invasive surgeries such as shoulder arthroscopy and knee arthroscopy.

[0020] Furthermore, this application also provides a mold for manufacturing the aforementioned rivets, which has many advantages. First, the mold body adopts a detachable upper and lower mold design, which greatly facilitates the assembly and disassembly of the mold. During the production process, whether it is daily maintenance, cleaning residue, or replacing worn parts, the operation is more convenient and efficient, effectively saving time and costs. The first and second casting grooves are connected to form a casting cavity with the same outline as the gentamicin-loaded silk fibroin rivet rod, which can accurately shape the rivet shape, and the one-piece molding avoids post-processing, ensuring product consistency and standardization, and meeting the high precision and high quality requirements of the medical field for instruments. Furthermore, the internal hexagonal prism, circular prism, and positioning seat in the inner core assembly are cleverly matched. The positioning seat ensures precise docking between the inner core and the casting cavity, the internal hexagonal prism corresponds to the internal hexagonal slot of the rivet, and the circular prism corresponds to the through hole. In addition, the holes and layered design on the positioning seat and the permeation holes on the mold body allow the external methanol solution to enter the casting cavity during the rivet preparation process and fully contact the silk fibroin solution, so as to solidify and form it. This precise internal structure design ensures that the internal structure of the manufactured rivets fully meets the usage requirements. Attached Figure Description

[0021] To more clearly illustrate the technical solutions of the embodiments of this utility model, the drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of this utility model and should not be regarded as a limitation on the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.

[0022] Figure 1 This is a front view of an antibacterial and absorbable gentamicin-loaded silk fibroin medical rivet according to an embodiment of the present invention;

[0023] Figure 2 for Figure 1 A partial cross-sectional diagram;

[0024] Figure 3 This is an isometric view of a mold according to an embodiment of the present invention;

[0025] Figure 4 This is a cross-sectional view of a mold according to an embodiment of the present utility model;

[0026] Figure 5 This is an exploded view of a mold according to an embodiment of the present invention.

[0027] Icons: 1-Gentamicin-loaded silk fibroin type nail rod, 2-External thread, 3-Internal hexagonal slot, 4-Through hole, 5-Mold body, 501-Upper mold, 502-Lower mold, 6-Positioning seat, 7-Threaded hole, 8-Sealing body, 9-Circular column, 10-Pouring cavity, 11-Permeation hole, 12-Drainage hole, 13-Internal hexagonal column, 14-Foot column. Detailed Implementation

[0028] The embodiments of this application will now be described in detail with reference to the accompanying drawings.

[0029] Example 1

[0030] Please refer to Figure 1 and Figure 2 This application provides an antibacterial and absorbable gentamicin-loaded fibroin medical rivet, comprising a gentamicin-loaded fibroin rivet 1. The first end face of the gentamicin-loaded fibroin rivet 1 is axially provided with an internal hexagonal notch 3. The bottom of the internal hexagonal notch 3 is axially provided with two through holes 4, and the end of any of the through holes 4 away from the internal hexagonal notch 3 penetrates the second end face of the gentamicin-loaded fibroin rivet 1. The outer ring surface of the gentamicin-loaded fibroin rivet 1 is provided with an external thread 2, and the pitch of the external thread 2 on the same side as the internal hexagonal notch 3 is less than the pitch of the external thread 2 on the same side as any of the through holes 4.

[0031] The antibacterial and absorbable gentamicin-loaded silk fibroin medical rivet provided in this application has significant advantages compared to traditional metal and polylactic acid materials. In terms of material, it eliminates the non-absorbability of metal, avoiding a series of potential problems that may arise from long-term metal retention in the body, such as foreign body reactions and interference with subsequent imaging examinations. It also overcomes the drawbacks of polylactic acid, such as slow absorption and a tendency to cause local inflammatory reactions. The gentamicin-loaded silk fibroin material not only degrades and is absorbed in the body in a timely manner, without causing long-term burden on the patient, but also possesses antibacterial properties due to the presence of gentamicin, effectively reducing the risk of postoperative infection and creating a favorable environment for wound healing. The differentiated setting of the two-pitch external threads at both ends when connecting to bone is particularly ingenious. This design allows the tightly threaded portion of the external thread 2 (with a smaller pitch) to connect more firmly with the outer layer of hard cortical bone after the rivet is screwed into the bone. Meanwhile, the looser threaded portion of the external thread 2 (with a larger pitch) reduces the cutting of cancellous bone as it penetrates deeper into the loose bone, increasing the compression of the cancellous bone around the screw. On the other hand, the gentamicin-loaded silk fibroin screw will slightly expand after absorbing water, further strengthening the screw's holding force within the bone. The advantages of the rivet's structure and material properties ensure that it achieves a firm and reliable fixation within the bone, making it less prone to loosening or being pulled out. This greatly improves the practicality and effectiveness of medical rivets in scenarios such as shoulder arthroscopic surgery.

[0032] In a preferred embodiment, one end of the external thread 2 is flush with the first end face of the gentamicin-loaded silk fibroin type nail rod 1, and the other end is spaced apart from the second end face of the gentamicin-loaded silk fibroin type nail rod 1.

[0033] In particular, along the direction from the first end face to the second end face of the gentamicin-loaded silk fibroin type nail rod 1, the diameter of the gentamicin-loaded silk fibroin type nail rod 1 between the external thread 2 and the second end face of the gentamicin-loaded silk fibroin type nail rod 1 gradually decreases.

[0034] In the above embodiments, when such rivets are implanted into bone, the distal end of the smaller-diameter second end face is more easily inserted into the bone tissue, reducing resistance during implantation and making the surgical operation smoother and more precise. Meanwhile, the relatively larger-diameter threaded rivet, once implanted, provides more stable support and fixation, acting like a solid base to better resist various stresses such as external tension and pressure, preventing loosening or displacement of the rivet during use. This gradient diameter design considers both the ease of implantation and the reliability of fixation, optimizing the performance of medical rivets in medical applications. It is particularly suitable for scenarios with high requirements for operating space and convenience, such as shoulder arthroscopy, effectively improving the success rate of surgery and the postoperative recovery of patients.

[0035] Example 2

[0036] Please refer to Figures 2-5 This application provides a mold for manufacturing the traditional Chinese medicine rivets mentioned in the first aspect, comprising: a mold body 5, including a detachably fitted upper mold 501 and a lower mold 502, wherein the upper mold 501 is provided with a first casting groove, and the lower mold 502 is provided with a second casting groove, and is connected to the first casting groove to form a casting cavity 10, the outer contour of the casting cavity 10 being the same as the outer contour of the gentamicin-loaded silk fibroin type rivet 1; wherein, both ends of the casting cavity 10 respectively penetrate the outer side of the mold body 5 on the same side; and a sealing body 8 detachably fitted to the first port of the casting cavity 10; and so on. The inner core assembly includes an internal hexagonal column 13, two circular columns 9, and a positioning seat 6. The positioning seat 6 is used for detachable engagement with the second port of the casting cavity 10. The internal hexagonal column 13 is disposed on the positioning seat 6. The two circular columns 9 are disposed on the end face of the internal hexagonal column 13 away from the positioning seat 6, and the axis of any of the circular columns 9 is parallel to the axis of the internal hexagonal column 13. When the positioning seat 6 is engaged with the second port of the casting cavity 10, the internal hexagonal column 13 and the two circular columns 9 extend into the casting cavity 10, and the internal hexagonal column 13 is coaxial with the casting cavity 10.

[0037] This application provides a mold for manufacturing the aforementioned rivets, which has many advantages. First, the mold body 5 adopts a detachable upper mold 501 and lower mold 502 design, which greatly facilitates the assembly and disassembly of the mold. During the production process, whether it is daily maintenance, cleaning residue, or replacing worn parts, the operation is more convenient and efficient, effectively saving time and costs. The first and second casting grooves are connected to form a casting cavity 10 with the same outline as the gentamicin-loaded silk fibroin rivet rod 1, which can accurately shape the rivet shape, ensuring product consistency and standardization, and meeting the high precision and high quality requirements of the medical field for instruments. Furthermore, the internal hexagonal column 13, circular column 9, and positioning seat 6 in the inner core assembly are cleverly matched. The positioning seat 6 ensures precise alignment between the inner core and the casting cavity 10. The internal hexagonal column 13 corresponds to the internal hexagonal slot 3 of the rivet, and the circular column 9 corresponds to the through hole 4. This precise internal structure forming design makes the internal structure of the manufactured rivet fully meet the usage requirements.

[0038] Specifically, mold legs 14 are provided on the mold body 5.

[0039] In a preferred embodiment, the positioning seat 6 is provided with a plurality of guide holes 12, and the axis of any of the guide holes 12 is parallel to the axis of the internal hexagonal column 13.

[0040] In the above embodiment, after the silk protein solution is poured into the mold body 5, the entire mold body 5 needs to be immersed in methanol solution for 3 days. This is because the methanol solution can solidify the silk protein solution upon contact with it, and the guide hole 12 facilitates the penetration of the methanol solution into the pouring cavity 10 to fully contact the silk protein solution, thus promoting better solidification. After 3 days, the sealing body 8 is removed. Since there are two support pillars 14 on the mold body 5, the mold pouring cavity 10 is suspended, allowing the methanol solution to enter the pouring cavity 10 through the holes in the sealing body 8, continuing to fully contact the silk protein solution and promoting better solidification.

[0041] Preferably, the second end of the casting cavity 10 is also provided with a permeation hole 11 for connecting the casting cavity 10 and the outside of the mold body 5 to allow the methanol solution to enter.

[0042] As a preferred embodiment, the positioning seat 6, the internal hexagonal column 13, and the two circular columns 9 are integrally formed.

[0043] In the above embodiments, the one-piece molding greatly enhances the integrity and stability of the structure, avoids the impact of subsequent machining on the overall structure of the rivet, and reduces the possibility of displacement or loosening of various components due to uneven stress during use, thereby ensuring that the inner core assembly can always accurately shape the complex internal structure of the medical rivet when used repeatedly.

[0044] In a preferred embodiment, the positioning seat 6 includes an overlapping and coaxially arranged first circular platform and a second circular platform, wherein the diameter of the second circular platform is smaller than the diameter of the first circular platform.

[0045] The second port of the casting cavity 10 is circular and is adapted to the second circular platform.

[0046] In the above embodiments, on the one hand, the smaller-diameter second circular platform is adapted to the port of the casting cavity 10, enabling more precise positioning and docking during mold use. This ensures that the inner core component is accurately inserted into the casting cavity 10, keeping the inner core always at the center of the rivet. This guarantees the precision and consistency of the internal structure of the produced medical rivets, better meeting the stringent requirements of medical applications. On the other hand, the larger-diameter first circular platform serves as a stable support surface, facilitating operator work during the installation and disassembly of the inner core component. This improves the ease of mold use and work efficiency. Furthermore, the first circular platform supports the inner core, preventing the second circular platform from being tightly pressed against the casting cavity 10, allowing the methanol solution to enter the casting cavity 10 more effectively.

[0047] In a preferred embodiment, the upper mold 501 and the lower mold 502 are detachably connected by bolts.

[0048] In the above embodiments, the bolted connection method makes the disassembly and assembly of the mold simple and easy. During routine maintenance, cleaning, and component replacement of the mold, operators can quickly separate the upper mold 501 and the lower mold 502, making it convenient to clean the residual casting material inside the mold, ensuring that the quality of the next casting is not affected. At the same time, it also allows for timely inspection and replacement of worn or damaged parts, reducing production downtime caused by mold failure and improving production efficiency.

[0049] Preferably, the upper mold 501 and the lower mold 502 are connected by multiple sets of bolts to improve the stability of their connection. Both the upper mold 501 and the lower mold 502 are provided with threaded holes 7 for the matching bolts.

[0050] In a preferred embodiment, the sealing body 8 is a stud and is threadedly engaged with the first port of the casting cavity 10.

[0051] In the above embodiments, the threaded fit ensures a tight connection between the sealing body 8 and the casting cavity 10, effectively preventing leakage of the casting material and ensuring a stable and reliable casting process, thereby guaranteeing the stability and consistency of the medical rivet molding quality. Furthermore, the threaded sealing body 8 is easy and quick to install and remove, facilitating mold cleaning and maintenance, improving operational efficiency during production, reducing production time costs, and making it suitable for large-scale production.

[0052] Furthermore, when casting rivets using the molds described in this application embodiment, the main steps include:

[0053] Solution preparation: Dissolve gentamicin sulfate in hexafluoroisopropanol at a concentration of 10 mg / ml. Cut the vacuum-dried silk into small pieces and put them into a 50 ml syringe. Add gentamicin-hexafluoroisopropanol solution at a ratio of 5 ml per milligram of silk protein. Invert the syringe and place it at room temperature until the silk protein is completely dissolved to obtain a 20 w / v % hexafluoroisopropanol / silk protein solution. Store at room temperature.

[0054] Mold processing and solution injection: The designed mold is fabricated using a precision lathe. After assembly, the first port of the casting cavity 10 is sealed with a sealing body 8. The prepared hexafluoroisopropanol / silk fibroin solution is injected into the casting cavity 10 using a syringe until it stops about 2 mm from the port of the casting cavity 10. Then, the inner core assembly is inserted, and the mold is placed in a vibrator and vibrated for 5 minutes to expel air and make the silk fibroin solution evenly distributed and compacted. After standing for 1 hour, the solution is evenly distributed under gravity. Then, it is soaked in methanol solution for 3 days. Methanol flows into the second port of the casting cavity 10 through the guide hole 12 and the permeation hole 11 and comes into full contact with the silk fibroin solution. After that, the sealing body 8 is removed. Since there are two foot pillars on the mold body 501 and 502, the mold casting cavity 10 is suspended, allowing methanol to continue to contact the silk fibroin from the first port of the casting cavity 10. After soaking for another 3 days, the gentamicin-loaded silk fibroin rivets gradually take shape and are completely cured.

[0055] Gradient water replacement and demolding: Perform gradient water replacement on the entire mold and molding material in 4 stages, with an interval of 1 hour between each stage. The water replacement sequence is 100% methanol, 75% methanol, 50% methanol, 25% methanol, and 100% water. After completion, allow the molding material to soak in water for at least 2 days. Open the mold. At this time, the material has shrunk, making it easier to demold. Cut the demolded rivets to 15mm in length with a blade, and then put the rivets into a 50℃ oven to dry for 6 hours.

[0056] Further processing: Properly grind the area between the two through holes 4 at the far end of the rivet so that the surface of the thread passing through is not higher than the surface of the rivet. Insert the thread to finally obtain the gentamicin-silk fibroin threaded rivet of the required length.

[0057] Furthermore, unless otherwise explicitly specified or limited, the terms "installation" and "connection" in this application embodiment should be interpreted broadly. For example, "connection" can be a detachable connection or a non-detachable connection; it can be a direct connection or an indirect connection through an intermediate medium. The terms "upper," "lower," "left," "right," "inner," "outer," and "side," etc., are merely for reference to the direction in the accompanying drawings or the usual placement of the product during use. They are only for clearly describing this application and do not indicate or imply that the device or component referred to must have a specific orientation, or be constructed and operated in a specific orientation. They should not be construed as limitations on this application. The terms "first," "second," etc., are only used for distinguishing descriptions and should not be construed as indicating or implying relative importance; "multiple" refers to at least two. In this application embodiment, the limitations on relative positional relationships such as parallel, perpendicular, and aligned are all relative to the current technological level and are not absolutely strict limitations. Slight deviations are allowed; approximations of parallel, perpendicular, and aligned are all acceptable. For example, "A and B are parallel" means that A and B are parallel or approximately parallel, and the angle between A and B can be between 0 degrees and 10 degrees.

[0058] The above are only some embodiments and implementation methods of this application. The protection scope of this application is not limited thereto. In the absence of conflict, the embodiments and features in the embodiments of this application can be combined with each other. Any combination of features in different embodiments is also within the protection scope of this application. Any changes or substitutions that can be easily conceived by those skilled in the art within the scope of the technology disclosed in this application should be included within the protection scope of this application.

Claims

1. An antibacterial absorbable gentamicin-carrying silk fibroin medical rivet, characterized in that, The device includes a gentamicin-loaded silk fibroin type nail rod (1), wherein the first end face of the gentamicin-loaded silk fibroin type nail rod (1) is axially provided with an internal hexagonal groove (3), and the bottom of the internal hexagonal groove (3) is axially provided with two through holes (4), and the end of any one of the through holes (4) away from the internal hexagonal groove (3) penetrates the second end face of the gentamicin-loaded silk fibroin type nail rod (1); The outer ring surface of the gentamicin-loaded silk fibroin type nail rod (1) is provided with an external thread (2), and the pitch of the external thread (2) on the same side as the internal hexagonal slot (3) is less than the pitch of the external thread (2) on the same side as any of the through holes (4).

2. The gentamicin-carrying absorbable silk fibroin medical rivet according to claim 1, wherein the gentamicin-carrying absorbable silk fibroin medical rivet is a medical rivet for use in the treatment of osteomyelitis. One end of the external thread (2) is flush with the first end face of the gentamicin-loaded silk fibroin type nail rod (1), and the other end is spaced apart from the second end face of the gentamicin-loaded silk fibroin type nail rod (1); In particular, along the direction from the first end face to the second end face of the gentamicin-loaded silk fibroin type nail (1), the diameter of the gentamicin-loaded silk fibroin type nail (1) between the external thread (2) and the second end face of the gentamicin-loaded silk fibroin type nail (1) gradually decreases.

3. A mold for manufacturing the medical rivet as claimed in claim 2, characterized by include: The mold body (5) includes a detachable upper mold (501) and a lower mold (502). The upper mold (501) is provided with a first pouring groove, and the lower mold (502) is provided with a second pouring groove, which is connected to the first pouring groove to form a pouring cavity (10). The outer contour of the pouring cavity (10) is the same as the outer contour of the gentamicin-loaded silk fibroin type nail rod (1). Wherein, the two ends of the casting cavity (10) respectively penetrate the outer side of the mold body (5) on the same side; A sealing body (8) that is detachably fitted to the first port of the casting cavity (10); as well as The inner core assembly includes an internal hexagonal column (13), two circular columns (9), and a positioning seat (6). The positioning seat (6) is used to detachably engage with the second port of the casting cavity (10). The internal hexagonal column (13) is disposed on the positioning seat (6). The two circular columns (9) are disposed on the end face of the internal hexagonal column (13) away from the positioning seat (6), and the axis of any circular column (9) is parallel to the axis of the internal hexagonal column (13). When the positioning seat (6) is connected to the second port of the casting cavity (10), the internal hexagonal column (13) and the two circular columns (9) extend into the casting cavity (10), and the internal hexagonal column (13) is coaxial with the casting cavity (10).

4. A mold according to claim 3, wherein The positioning seat (6) is provided with a plurality of guide holes (12), and the axis of any one of the guide holes (12) is parallel to the axis of the internal hexagonal column (13).

5. A mold according to claim 3, wherein The positioning seat (6), the internal hexagonal column (13), and the two circular columns (9) form an integral molded structure.

6. A mold according to claim 5, wherein The positioning seat (6) includes an overlapping and coaxially arranged first circular platform and a second circular platform, wherein the diameter of the second circular platform is smaller than the diameter of the first circular platform. The second port of the pouring cavity (10) is circular and matches the second circular table.

7. A mold according to claim 3, characterized in that, The upper mold (501) and the lower mold (502) are detachably matched through bolts.

8. A mold according to claim 3, wherein The sealing body (8) is a threaded stud and is threadedly matched with the first port of the pouring cavity (10).

Images