Micro-scale automatic oscillation uniform mixing device

Abstract

The utility model discloses a trace automatic oscillation blending device which comprises a guide sleeve, a sleeve bottom cover detachably arranged in the middle of the lower end of the guide sleeve, a reagent tube supporting table arranged in the middle of the inner wall of the guide sleeve in a sliding mode, and a reagent tube lantern ring arranged over the reagent tube supporting table. A trace reagent tube is arranged in the middle of the reagent tube lantern ring, and the self-adaptive variable-diameter calibration mechanism is arranged in the middle of the reagent tube lantern ring and is used for centering and positioning the trace reagent tube; the eccentric reciprocating lifting mechanism is arranged at the bottom of the reagent tube supporting table and is used for vibrating the trace reagent tubes. By arranging the eccentric reciprocating lifting mechanism and utilizing the intermittent transmission mode of the inclined eccentric wheel and the linkage lock teeth, the reagent tube supporting table and the trace reagent tube can be driven to do reciprocating lifting motion along the guide sleeve, it is guaranteed that plasma and blood cells form the turbulent flow uniform mixing effect in the vertical direction, and the problem that existing layered interfaces are not sufficient in uniform mixing is solved.

Description

Technical Field

[0001] This utility model relates to the field of blood cell analysis technology, and in particular to a micro-volume automatic shaking and mixing device. Background Technology

[0002] Blood cell analysis is one of the core technologies in clinical laboratory medicine. By quantitatively and qualitatively detecting the morphology, quantity, and functional parameters of various cells in the blood, it provides crucial evidence for disease diagnosis, efficacy evaluation, and health screening. This technology relies on principles such as flow cytometry, impedance spectroscopy, optical detection, and immunochemistry to accurately measure the counts and subgroups of red blood cells, white blood cells, and platelets. It can also analyze more than 30 indicators, including hemoglobin concentration, hematocrit, and leukocyte differentiation antigen expression. Its clinical applications cover areas such as anemia identification, leukemia classification, infection type determination, coagulation function assessment, and tumor chemotherapy monitoring. It has irreplaceable value, especially in the diagnosis of hematological diseases.

[0003] Blood cell analysis requires the collection of venous blood or a small amount of blood sample. Due to the special needs of pediatric and emergency patients, small amounts of blood sample are often used in clinical practice. This sample must be left to stand for more than ten minutes to allow the blood cells and plasma to separate due to the difference in specific gravity. Therefore, it must be thoroughly mixed before testing. Traditional mechanical equipment generally relies on shaking to achieve the purpose of mixing, which leads to insufficient mixing at the interface between blood cells and plasma, which can easily affect the accuracy of test results. To address this, a micro-volume automatic shaking mixing device is provided. Utility Model Content

[0004] In order to overcome the shortcomings of the existing technology, this utility model proposes a micro-volume automatic vibration mixing device.

[0005] To solve the above-mentioned technical problems, the basic technical solution proposed by this utility model is as follows:

[0006] A micro-volume automatic oscillation mixing device includes a guide sleeve, a sleeve bottom cover detachably disposed at the lower middle part of the guide sleeve, a reagent tube support slidably disposed at the middle part of the inner wall of the guide sleeve, and a reagent tube collar disposed directly above the reagent tube support, wherein a micro-reagent tube is disposed at the middle part of the reagent tube collar, and further includes:

[0007] An adaptive diameter calibration mechanism is set in the middle of the reagent tube collar and is used to center and position the micro reagent tube. The adaptive diameter calibration mechanism consists of three pressing components arranged in a ring with equal spacing.

[0008] An eccentric reciprocating lifting mechanism is located at the bottom of the reagent tube holder and is used to oscillate micro-reagent tubes.

[0009] Preferably, the pressing assembly includes a threaded knob disposed on the inner wall of the reagent tube collar, a clamping guide rod slidably disposed on the inner wall of the threaded knob, a vertical clamping plate fixedly disposed on the clamping guide rod facing the middle of one end of the micro-reagent tube, a compression spring wound around the outer wall of the clamping guide rod and close to the vertical clamping plate, and a clamping guide plate fixedly disposed on the outer wall of the vertical clamping plate and close to the reagent tube collar. The threaded knob and the reagent tube collar are engaged by threads, the compression spring is connected to the vertical clamping plate, and the compression spring and the threaded knob rotate relative to each other. Both the upper and lower ends of the vertical clamping plate are provided with slopes.

[0010] Preferably, the pressing assembly further includes a plurality of rubber wheels arranged vertically at equal intervals on the inner wall of the vertical clamping plate, and a damping ring disposed at both ends of each of the rubber wheels, wherein the damping ring is connected to the vertical clamping plate, and the rubber wheel and the damping ring rotate relative to each other.

[0011] Preferably, the eccentric reciprocating lifting mechanism includes a push-pull block fixedly disposed at the middle of the lower end of the reagent tube holder, a tension spring disposed inside the push-pull block, and two linkage locking teeth fixed to the same outer wall of the push-pull block. The two linkage locking teeth are arranged vertically in a corresponding manner along the height direction of the outer wall, and the two linkage locking teeth have the same structure. The push-pull block and the sleeve bottom cover are elastically disposed by the tension spring.

[0012] Preferably, the eccentric reciprocating lifting mechanism further includes a drive shaft near the push-pull block and an inclined eccentric wheel fixedly disposed on the outer wall of the drive shaft and located between two linkage locking teeth. The drive shaft and the sleeve bottom cover are rotatably disposed via bearings. The inclined eccentric wheel rotates relative to the linkage locking teeth. The lower end of the drive shaft is connected and assembled to the output end of the external drive component.

[0013] Preferably, three equally spaced ring-shaped connecting arms are provided between the reagent tube sleeve and the reagent tube support, and the reagent tube sleeve and the reagent tube support are connected by the ring-shaped connecting arms. Three equally spaced sliders are fixedly provided on the outer wall of the reagent tube support, and a sliding groove is provided through the outer wall of the guide sleeve at each slider position.

[0014] Preferably, the reagent tube collar includes a pressure-locking mechanism for pressing the micro-reagent tube. The pressure-locking mechanism includes a flipping arm disposed on one side of the upper end of the reagent tube collar, an arm shaft disposed at the bottom of the flipping arm, a horizontal plate fixedly disposed on the upper end of the flipping arm, a tightening screw disposed on the inner wall of the horizontal plate by means of a thread, and a rubber pressure head fixedly disposed in the middle of the lower end of the tightening screw. The tightening screw corresponds to the position of the reagent tube collar, and the flipping arm and the reagent tube collar are rotatably disposed via the arm shaft.

[0015] The beneficial effects of this utility model are:

[0016] By setting up an eccentric reciprocating lifting mechanism, and using the intermittent transmission method of the inclined eccentric wheel and the linkage locking teeth, the reagent tube support and the micro reagent tube can be driven to reciprocate and lift along the guide sleeve, ensuring that the plasma and blood cells form a turbulent mixing effect in the vertical direction, thus solving the problem of insufficient mixing at the existing layered interface.

[0017] By setting up an adaptive variable diameter calibration mechanism, three ring-shaped pressing components can stably center and fix micro-reagent tubes of different specifications. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0019] Figure 2 This is a schematic diagram of the internal structure of the guide sleeve of this utility model. Figure 1 ;

[0020] Figure 3 This is a schematic diagram of the adaptive variable diameter calibration mechanism of this utility model;

[0021] Figure 4 This is a schematic diagram of the internal structure of the guide sleeve of this utility model. Figure 2 .

[0022] Explanation of reference numerals in the attached figures:

[0023] 100. Guide sleeve; 101. Slide groove; 200. Sleeve bottom cover; 300. Eccentric reciprocating lifting mechanism; 301. Tension spring; 302. Linkage locking tooth; 303. Drive shaft; 304. Inclined eccentric wheel; 305. Push-pull block; 400. Adaptive diameter calibration mechanism; 401. Vertical clamping plate; 402. Damping ring; 403. Rubber wheel; 404. Compression spring; 405. Threaded knob; 406. Clamping plate guide rod; 407. Clamping plate guide plate; 500. Ring platform connecting arm; 600. Reagent tube collar; 700. Pressure locking mechanism; 701. Flipping arm; 702. Horizontal plate; 703. Tightening screw; 704. Rubber pressure head; 705. Arm shaft; 800. Micro-reagent tube; 900. Reagent tube support; 901. Slider; 902. Rubber support. Detailed Implementation

[0024] The following will be combined with the appendix Figure 1 To be continued Figure 4 The technical solutions in the embodiments of this utility model are clearly and completely described. Obviously, the described embodiments are only a part of the embodiments of this utility model, and not all of them. Based on the embodiments of this utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of this utility model.

[0025] This utility model provides a technical solution: a micro-volume automatic oscillation mixing device, including a guide sleeve 100, a sleeve bottom cover 200 detachably disposed at the lower middle part of the guide sleeve 100, a reagent tube support 900 slidably disposed at the middle part of the inner wall of the guide sleeve 100, and a reagent tube collar 600 disposed directly above the reagent tube support 900. Three equally spaced ring-shaped connecting arms 500 are provided between the reagent tube collar 600 and the reagent tube support 900, and the reagent tube collar 600 and the reagent tube support 900 are connected by the ring-shaped connecting arms 500, allowing the reagent tube collar 600 to rise and fall synchronously with the reagent tube support 900. The device includes a micro-reagent tube 800 located in the middle of the reagent tube collar 600. It also includes an adaptive diameter calibration mechanism 400 located in the middle of the reagent tube collar 600 for centering and positioning the micro-reagent tube 800. The adaptive diameter calibration mechanism 400 consists of three pressing components arranged in a ring at equal intervals. The three pressing components move closer or further apart to clamp and release the micro-reagent tube 800, which is positioned between the three pressing components. An eccentric reciprocating lifting mechanism 300 located at the bottom of the reagent tube support 900 for oscillating the micro-reagent tube 800 is also included to mix the sample filled inside the micro-reagent tube 800.

[0026] Specifically, the pressing assembly includes a threaded knob 405 disposed on the inner wall of the reagent tube collar 600, a clamping guide rod 406 slidably disposed on the inner wall of the threaded knob 405, a vertical clamping plate 401 fixedly disposed on the clamping guide rod 406 facing the middle of one end of the micro-reagent tube 800 for supporting the micro-reagent tube 800, a compression spring 404 wound around the outer wall of the clamping guide rod 406 and close to the vertical clamping plate 401 for providing thrust to the vertical clamping plate 401, and a clamping guide plate 407 fixedly disposed on the outer wall of the vertical clamping plate 401 and close to the reagent tube collar 600 for correcting the vertical clamping plate 401 and preventing the vertical clamping plate 401 from rotating. The upper end of the clamping guide plate 407 contacts the lower end of the reagent tube collar 600, and the clamping guide plate 407 and the reagent tube... The collar 600 slides relative to each other, and the threaded knob 405 is engaged with the reagent tube collar 600 by threads. The compression spring 404 is connected to the vertical clamping plate 401, and the compression spring 404 and the threaded knob 405 rotate relative to each other. In this way, medical personnel can further compress the compression spring 404 by rotating the threaded knob 405, increasing the thrust of the vertical clamping plate 401 to increase the clamping force. Both the upper and lower ends of the vertical clamping plate 401 are provided with slopes. The pressing assembly also includes multiple rubber wheels 403 arranged vertically and equidistantly on the inner wall of the vertical clamping plate 401, and damping rings 402 set at both ends of each rubber wheel 403 to provide resistance to the damping rings 402 and ensure the overall stability of the micro-reagent tube 800. The damping rings 402 are connected to the vertical clamping plate 401, and the rubber wheels 403 and the damping rings 402 rotate relative to each other.

[0027] Specifically, the eccentric reciprocating lifting mechanism 300 includes a push-pull block 305 fixedly disposed at the lower middle part of the reagent tube holder 900, a tension spring 301 disposed inside the push-pull block 305, and two linkage locking teeth 302 both fixed to the same outer wall of the push-pull block 305. The two linkage locking teeth 302 are arranged vertically in a corresponding manner along the height direction of the outer wall, and the two linkage locking teeth 302 have the same structure. The push-pull block 305 and the sleeve bottom cover 200 are elastically set by the tension spring 301. The eccentric reciprocating lifting mechanism 300 also includes a drive shaft 303 near the push-pull block 305, and an inclined eccentric wheel 304 fixedly disposed on the outer wall of the drive shaft 303 and located between the two linkage locking teeth 302. When the inclined eccentric wheel 304 rotates, the raised parts at both ends can cooperate with the two linkage locking teeth. 302 drives the push-pull block 305 to rise and fall. The drive shaft 303 and the sleeve bottom cover 200 are rotatably set through bearings. The outer side of the tilting eccentric wheel 304 extends deep between the two linkage locking teeth 302 and is locked. The tilting eccentric wheel 304 and the linkage locking teeth 302 rotate relative to each other. The lower end of the drive shaft 303 is connected and assembled to the output end of the external drive component, which is the electric motor. It is not shown or labeled in the attached drawings of the instruction manual. As it is prior art, it will not be described in detail here. It is worth noting that the lower end of the push-pull block 305 is far enough away from the upper end of the sleeve bottom cover 200 so that it will not touch the sleeve bottom cover 200 when the push-pull block 305 reaches the lowest position. The upper end of the drive shaft 303 is far enough away from the lower end of the reagent tube support 900 so that it will not touch the drive shaft 303 when the reagent tube support 900 reaches the lowest position.

[0028] Specifically, the reagent tube collar 600 includes a pressure-locking mechanism 700 for clamping the micro-reagent tube 800, which prevents the micro-reagent tube 800 from falling off during vibration. The pressure-locking mechanism 700 includes a flipping arm 701 located on one side of the upper end of the reagent tube collar 600, an arm shaft 705 located at the bottom of the flipping arm 701, a horizontal plate 702 fixedly located at the upper end of the flipping arm 701, a tightening screw 703 threadedly engaged with the inner wall of the horizontal plate 702, and a rubber pressure head 704 fixedly located at the middle of the lower end of the tightening screw 703. The tightening screw 703 is positioned opposite to the reagent tube collar 600. The rubber pressure head 704 should be aligned precisely with the micro-reagent tube 800 to be compressed. The flip arm 701 and the reagent tube collar 600 are rotatably set via the arm shaft 705. Three sliders 901 are fixedly set on the outer wall of the reagent tube support 900 and arranged in a ring with equal spacing. The outer wall of the guide sleeve 100 and the position of each slider 901 are provided with a through groove 101. The sliders 901 slide on the inner wall of the groove 101. The sliders 901 and the groove 101 can effectively guide the reagent tube support 900. A rubber support 902 is fixedly set in the middle of the upper end of the reagent tube support 900 to support the bottom area of ​​the micro-reagent tube 800.

[0029] Based on the above, this utility model, by setting an eccentric reciprocating lifting mechanism 300, utilizes the intermittent transmission method of the inclined eccentric wheel 304 and the linkage locking tooth 302 to drive the reagent tube support 900 and the micro-reagent tube 800 to reciprocate and lift along the guide sleeve 100, ensuring that plasma and blood cells form a turbulent mixing effect in the vertical direction, thus solving the problem of insufficient mixing at the existing layered interface. Furthermore, by setting an adaptive variable diameter calibration mechanism 400, three ring-arranged pressing components can stably center and fix micro-reagent tubes 800 of different specifications. Finally, by setting a pressure-locking mechanism 700, the mechanism utilizes a flipping mechanism... Arm 701 and rubber pressure head 704 can apply continuous downward vertical pressure to the opening of the micro-reagent tube 800 during oscillation. Together with the lateral clamping of the vertical clamping plate 401, they form a three-dimensional fixed structure to ensure that the micro-reagent tube 800 does not move axially or come out during high-frequency reciprocating motion. By setting a rubber support 902 at the upper end of the reagent tube support 900, the elastic material's buffering and energy absorption characteristics can form flexible support for the bottom of the micro-reagent tube 800 during the emergency stop and start phase of the eccentric reciprocating lifting mechanism 300, avoiding the bottom of the micro-reagent tube 800 from breaking due to rigid impact and ensuring the safety of equipment operation.

[0030] Based on the disclosure and teachings of the above specification, those skilled in the art can make changes and modifications to the above embodiments. Therefore, this utility model is not limited to the specific embodiments disclosed and described above, and some modifications and changes to this utility model should also fall within the protection scope of the claims of this utility model. Furthermore, although some specific terms are used in this specification, these terms are only for convenience of explanation and do not constitute any limitation on this utility model.

Claims

1. A micro-volume automatic oscillation mixing device, characterized in that, The system includes a guide sleeve (100), a sleeve bottom cover (200) detachably disposed at the lower middle part of the guide sleeve (100), a reagent tube support (900) slidably disposed at the middle part of the inner wall of the guide sleeve (100), and a reagent tube collar (600) disposed directly above the reagent tube support (900), wherein a micro-reagent tube (800) is disposed at the middle part of the reagent tube collar (600), and further includes: An adaptive variable diameter calibration mechanism (400) is provided in the middle of the reagent tube collar (600) and is used to center and position the micro reagent tube (800). The adaptive variable diameter calibration mechanism (400) consists of three pressing components arranged in a ring with equal spacing. An eccentric reciprocating lifting mechanism (300) is located at the bottom of the reagent tube holder (900) and is used to oscillate the micro-reagent tube (800).

2. The micro-volume automatic oscillation mixing device according to claim 1, characterized in that: The pressing assembly includes a threaded knob (405) disposed on the inner wall of the reagent tube collar (600), a clamping guide rod (406) slidably disposed on the inner wall of the threaded knob (405), a vertical clamping plate (401) fixedly disposed on the middle of the end of the clamping guide rod (406) facing the micro-reagent tube (800), and a compression spring (404) wrapped around the outer wall of the clamping guide rod (406) and positioned near the vertical clamping plate (401). The vertical clamping plate (401) is fixedly installed on the outer wall of the vertical clamping plate (401) and near the reagent tube sleeve (600). The threaded knob (405) is engaged with the reagent tube sleeve (600) by threads. The compression spring (404) is connected to the vertical clamping plate (401) and rotates relative to the threaded knob (405). Both the upper and lower ends of the vertical clamping plate (401) are provided with slopes.

3. The micro-volume automatic oscillation mixing device according to claim 2, characterized in that: The pressing assembly also includes multiple rubber wheels (403) arranged vertically at equal intervals on the inner wall of the vertical clamping plate (401), and damping rings (402) disposed at both ends of each of the rubber wheels (403), the damping rings (402) being connected to the vertical clamping plate (401), and the rubber wheels (403) and damping rings (402) rotating relative to each other.

4. The micro-volume automatic oscillation mixing device according to claim 1, characterized in that: The eccentric reciprocating lifting mechanism (300) includes a push-pull block (305) fixedly disposed at the middle of the lower end of the reagent tube holder (900), a tension spring (301) disposed inside the push-pull block (305), and two linkage locking teeth (302) both fixed to the same outer wall of the push-pull block (305). The two linkage locking teeth (302) are arranged vertically in a corresponding manner along the height direction of the outer wall, and the two linkage locking teeth (302) have the same structure. The push-pull block (305) and the sleeve bottom cover (200) are elastically set by the tension spring (301).

5. A micro-volume automatic oscillation mixing device according to claim 4, characterized in that: The eccentric reciprocating lifting mechanism (300) also includes a drive shaft (303) located near the push-pull block (305) and an inclined eccentric wheel (304) fixedly disposed on the outer wall of the drive shaft (303) and located between two linkage locking teeth (302). The drive shaft (303) and the sleeve bottom cover (200) are rotatably disposed by bearings. The inclined eccentric wheel (304) rotates relative to the linkage locking teeth (302). The lower end of the drive shaft (303) is connected and assembled to the output end of the external drive component.

6. The micro-volume automatic oscillation mixing device according to claim 1, characterized in that: Three equally spaced ring-shaped connecting arms (500) are provided between the reagent tube collar (600) and the reagent tube support (900), and the reagent tube collar (600) and the reagent tube support (900) are connected by the ring-shaped connecting arms (500). Three equally spaced sliders (901) are fixedly provided on the outer wall of the reagent tube support (900). A groove (101) is provided through the outer wall of the guide sleeve (100) at each slider (901). A rubber support (902) is fixedly provided at the middle of the upper end of the reagent tube support (900).

7. A micro-volume automatic oscillation mixing device according to claim 6, characterized in that: The reagent tube collar (600) includes a pressure locking mechanism (700) for pressing the micro-reagent tube (800). The pressure locking mechanism (700) includes a flip arm (701) disposed on one side of the upper end of the reagent tube collar (600), an arm shaft (705) disposed at the bottom of the flip arm (701), a horizontal plate (702) fixedly disposed on the upper end of the flip arm (701), a tightening screw (703) engaged with the inner wall of the horizontal plate (702) by a thread, and a rubber pressure head (704) fixedly disposed at the middle of the lower end of the tightening screw (703). The tightening screw (703) is positioned corresponding to the reagent tube collar (600), and the flip arm (701) and the reagent tube collar (600) are rotatably disposed through the arm shaft (705).

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