Visual puncture oocyte retrieval needle

Abstract

The embodiment of the present specification provides a visual puncture oocyte retrieval needle, comprising: a needle tube, the needle tube comprising a distal end and a proximal end, an inside of the needle tube comprising a cavity, the cavity of the needle tube being open to tissue, the distal end of the needle tube comprising a needle tip and an ultrasonic imaging segment, the ultrasonic imaging segment being arranged at a rear end of the needle tip; a handle, the handle comprising a connecting structure and at least two branch pipes, the handle being connected to the proximal end of the needle tube through the connecting structure, the at least two branch pipes being arranged at the proximal end of the handle, a first branch pipe in the at least two branch pipes of the handle being connected to a suction pipe; an imaging illumination device, the imaging illumination device being connected to a second branch pipe of the at least two branch pipes of the handle, the imaging illumination device extending to the distal end of the needle tube through the cavity of the needle tube via the connecting structure.

Description

Technical Field

[0001] This manual relates to the field of medical devices, and in particular to a visual puncture needle for egg retrieval. Background Technology

[0002] Ovarian egg retrieval is a crucial step in assisted reproductive technology (ART), used to treat infertility or ovarian dysfunction. The procedure is primarily divided into vaginal and abdominal egg retrieval. Abdominal egg retrieval is mainly suitable for cases where eggs cannot be retrieved vaginally due to congenital absence of the vagina, incomplete vaginal development, or high ovarian position. Egg retrieval is a critical step in all IVF processes because, clinically, egg quality determines embryo quality, and the number of eggs retrieved determines the total number of embryos that can be cultured. Currently, the egg retrieval process cannot be directly observed, and there are certain risks to its accuracy and safety.

[0003] Therefore, there is a need to develop a new visual puncture needle for egg retrieval that allows for direct visualization during the procedure, improving the safety and accuracy of the retrieval process, reducing surgical trauma and recovery time, and thus improving the patient's surgical experience and postoperative recovery. Utility Model Content

[0004] This specification provides one or more embodiments of a visual puncture oocyte retrieval needle, comprising: a needle tube including a distal end and a proximal end, the interior of the needle tube including a cavity open to tissue, the distal end of the needle tube including a needle tip and an ultrasound-enhancing section disposed at the rear end of the needle tip; a handle including a connecting structure and at least two branch tubes, the handle being connected to the proximal end of the needle tube via the connecting structure, the at least two branch tubes being disposed at the proximal end of the handle, the first branch tube of the at least two branch tubes of the handle being connected to a suction tube; and an imaging illumination device connected to the second branch tube of the at least two branch tubes of the handle, the imaging illumination device extending through the connecting structure, through the cavity of the needle tube, to the distal end of the needle tube.

[0005] In some embodiments, the suction tube enters through the port of the first branch tube and extends into the cavity of the needle tube.

[0006] In some embodiments, the suction cavity is the lumen inside the suction tube.

[0007] In some embodiments, the suction tube is fitted onto the port of the first branch tube.

[0008] In some embodiments, the inner cavity of the handle and the cavity of the needle are connected to form a suction cavity.

[0009] In some embodiments, the suction tube is connected to the proximal ports of at least two branch tubes of the handle, and the inner cavity of the handle and the cavity of the needle tube are connected to form a suction cavity.

[0010] In some embodiments, the number of branch tubes is three, and the handle also includes a third branch tube, the port of which is connected to the infusion tube, and the infusion tube extends through the port of the third branch tube into the cavity of the needle tube.

[0011] In some embodiments, the second branch tube includes at least one bypass interface, one of which is connected to the infusion tube, the infusion tube extending through the bypass interface into the cavity of the needle tube.

[0012] In some embodiments, the imaging illumination device is inserted into the lumen of the infusion tube and extends along the lumen to the distal end of the needle.

[0013] In some embodiments, the needle tube includes an inner tube and an outer tube. The distal end of the inner tube has a needle tip, and the lumen of the inner tube is the cavity of the needle tube. A locking hole is provided on the distal sidewall of the outer tube, and the locking hole is connected to the cavity of the needle tube. The target substance enters the cavity of the needle tube through the locking hole.

[0014] One or more embodiments of this specification provide a method of using a visual puncture oocyte retrieval needle as described in any one of the above, the method comprising: inserting an imaging illumination device through the port of a second branch tube of the handle, through the connecting structure of the handle, through the cavity of the needle tube, and extending to the distal end of the needle tube; connecting an aspiration tube to a first branch tube; inserting the visual puncture oocyte retrieval needle into the target location through the puncture site under the guidance of the imaging illumination device; and collecting the target material through the aspiration tube.

[0015] The following beneficial effects can be achieved by using the visual puncture needle described in this instruction manual:

[0016] 1) When using the visual puncture needle in some embodiments of this specification for puncture, the direction of needle insertion can be clearly observed under the guidance of the ultrasound guidance device, and the imaging illumination device can directly view the surrounding image of the puncture path, which improves the safety and accuracy of puncture.

[0017] 2) During egg retrieval, the imaging illumination device allows direct observation of the follicles within the ovary. Under direct vision, the needle is inserted into the follicle to collect follicular fluid. Furthermore, the dual positioning using ultrasound imaging and real-time imaging effectively improves the egg retrieval rate, reduces the risk of accidental puncture, minimizes surgical trauma and recovery time, thereby improving the patient's surgical experience and postoperative recovery.

[0018] 3) The visual puncture oocyte retrieval needle in some embodiments of this specification integrates imaging, aspiration, and infusion functions. It is highly integrated and can be used to retrieve oocytes after one puncture without the need to withdraw the needle and perform another puncture, thus improving safety.

[0019] 4) The double-layer needle structure uses a locking hole and opening and closing mechanism to direct suction, optimize negative pressure distribution, prevent oocytes from flowing through the sharp needle tip, and improve the success rate of oocyte retrieval. Attached Figure Description

[0020] This specification will be further described by way of exemplary embodiments, which will be described in detail with reference to the accompanying drawings. These embodiments are not limiting; in these embodiments, the same reference numerals denote the same structures, wherein:

[0021] Figure 1 This is a schematic diagram of an exemplary application scenario 400 of a visual puncture oocyte retrieval needle according to some embodiments of this application;

[0022] Figure 2 This is a schematic diagram of another exemplary application scenario 600 of the visual puncture oocyte retrieval needle according to some embodiments of this application;

[0023] Figure 3 This is an exemplary structural schematic diagram of a visual puncture oocyte retrieval needle 100 shown in some embodiments of this specification;

[0024] Figure 4 This is an exemplary enlarged structural schematic diagram of the distal end of a visual puncture oocyte retrieval needle according to some embodiments of this specification;

[0025] Figure 5 This is a perspective view of the distal end of an exemplary needle tube of a visual puncture oocyte retrieval needle according to some embodiments of this specification.

[0026] Figure 6 This is a perspective view of an exemplary handle of a visual puncture oocyte retrieval needle according to some embodiments of this specification;

[0027] Figure 7 This is yet another specific schematic diagram of an exemplary visual puncture oocyte retrieval needle according to some embodiments of this specification;

[0028] Figure 8 This is yet another perspective view of the distal end of an exemplary needle tube of a visual puncture oocyte retrieval needle shown in some embodiments of this specification.

[0029] Figure 9 This is yet another perspective view of an exemplary handle of a visual puncture oocyte retrieval needle shown in some embodiments of this specification;

[0030] Figure 10 This is yet another specific schematic diagram of an exemplary visual puncture oocyte retrieval needle according to some embodiments of this specification;

[0031] Figure 11This is yet another perspective view of the distal end of an exemplary needle tube of a visual puncture oocyte retrieval needle shown in some embodiments of this specification.

[0032] Figure 12 This is a schematic cross-sectional view of the distal end of an exemplary needle tube of a visual puncture oocyte retrieval needle according to some embodiments of this specification.

[0033] Figure 13 This is yet another perspective view of an exemplary handle of a visual puncture oocyte retrieval needle shown in some embodiments of this specification;

[0034] Figure 14 This is a schematic diagram of the distal end of the visual puncture oocyte retrieval needle during the puncture process, as shown in some embodiments of this specification.

[0035] Figure 15 This is a schematic diagram of the distal end of the visual puncture oocyte retrieval needle during the oocyte retrieval process, as shown in some embodiments of this specification.

[0036] Figure 16 This is another structural schematic diagram of the distal end of the visual puncture oocyte retrieval needle during the oocyte retrieval process, as shown in some embodiments of this specification.

[0037] Figure 17 This is an exemplary structural diagram of the distal end of the outer tube as shown in some embodiments of this specification. Detailed Implementation

[0038] To more clearly illustrate the technical solutions of the embodiments in this specification, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are merely some examples or embodiments of this specification. For those skilled in the art, these drawings can be applied to other similar scenarios without creative effort. Unless obvious from the context or otherwise specified, the same reference numerals in the drawings represent the same structures or operations.

[0039] It should be understood that the terms “system,” “device,” “unit,” and / or “module” used herein are one way to distinguish different components, elements, parts, sections, or assemblies at different levels. However, if other terms can achieve the same purpose, they may be replaced by other expressions.

[0040] As indicated in this specification and claims, unless the context clearly indicates otherwise, the words "a," "an," "an," and / or "the" do not specifically refer to the singular and may also include the plural. Generally speaking, the terms "comprising" and "including" only indicate the inclusion of expressly identified steps and elements, which do not constitute an exclusive list, and the method or apparatus may also include other steps or elements.

[0041] Flowcharts are used in this specification to illustrate the operations performed by the system according to embodiments of this specification. It should be understood that the preceding or following operations are not necessarily performed in exact order. Instead, the steps can be processed in reverse order or simultaneously. Furthermore, other operations can be added to these processes, or one or more steps can be removed from them.

[0042] While this application makes various references to certain components in the embodiment apparatus, any number of different components may be applied to the embodiment apparatus. The components are merely illustrative. The apparatus may include different components in different application or installation scenarios. Components or structures not described in this specification, unless specifically emphasized, do not imply that the apparatus in this specification excludes or does not include the described components or structures.

[0043] The embodiments of this application can be applied to fields other than visual puncture for egg retrieval. It should be understood that the application scenarios of the device in this application are merely some examples or embodiments of this application, and those skilled in the art may apply this application to other similar fields, such as the field of puncture, without creative effort.

[0044] It should be noted that the following descriptions of various embodiments of the visual puncture oocyte retrieval device are for convenience only and should not limit this application to the scope of the embodiments described. It should be understood that those skilled in the art, after understanding the principle of the device, can arbitrarily combine the various components, incorporate them as part of other structures, or make various formal and detailed modifications and changes to the application field of the device without departing from this principle. Furthermore, the accompanying drawings in this application are merely a relatively intuitive visual description of the various devices or components and are only illustrative. The structure, shape, number of substructures, and types of substructures of the various devices or components in the drawings are for convenience of description only and do not limit the actual structure, shape, number of substructures, or types of substructures of the various devices or components. Structures not shown in the drawings, unless specifically emphasized in the relevant description, do not indicate or imply that the described device or component does not include that structure.

[0045] This manual provides a visual puncture oocyte retrieval needle 100, the application scenario of which can be found in [reference 400]. Figure 1The female reproductive system includes the vagina, uterus 401, fallopian tubes 402, ovary 403, and follicles 404. The ovary contains at least one follicle. In some embodiments, during oocyte retrieval, a visual puncture needle can be used in conjunction with an ultrasound-guided device. The ultrasound-guided device includes an ultrasound probe 500 and a corresponding display (not shown). In some embodiments, the ultrasound-guided device can provide the operator (e.g., a physician) with real-time images of the ovary to guide the precise positioning of the retrieval needle and ensure safe and efficient oocyte retrieval. The visual puncture needle 100 can be used to retrieve oocytes by puncturing into the follicles of the ovary.

[0046] Figure 1 This is a schematic diagram of an exemplary application scenario 400 of a visual puncture oocyte retrieval needle according to some embodiments of this application.

[0047] like Figure 1 As shown, in application scenario 400, during the operation (egg retrieval) of the visual puncture oocyte retrieval needle 100, the ultrasound probe 500 can be inserted into the uterus 401 through the vagina. The visual puncture oocyte retrieval needle 100 can be inserted through the vagina and sequentially into the uterus 401 and the ovarian wall to enter the ovary 403. A negative pressure device (not shown) connected to the visual puncture oocyte retrieval needle is activated, allowing further puncture into the target location (mature follicle) of the ovary 403 to aspirate the follicular fluid containing oocytes and granulosa cells. The visual puncture oocyte retrieval needle can provide the operator (e.g., a doctor) with a real-time image of the area surrounding the distal end of the needle. In some embodiments, negative pressure aspiration can be used to aspirate the follicular fluid from the mature follicle.

[0048] Figure 2 This is a schematic diagram of another exemplary application scenario 600 of the visual puncture oocyte retrieval needle according to some embodiments of this application.

[0049] like Figure 2 As shown, in application scenario 600, the ultrasound probe 500 can be placed against the outer skin 405 of the abdomen where the uterus is located. The visual puncture oocyte retrieval needle 100 can sequentially puncture the skin, subcutaneous fat, and muscle tissue of the woman's abdomen, and then enter the pelvic cavity to aspirate the follicular fluid from the mature follicles in the ovaries 403.

[0050] exist Figure 1 and Figure 2 In this application, the ultrasound probe 500 can be used to acquire ultrasound images and can be used in conjunction with the visual puncture oocyte retrieval needle provided in this application. The position of the ultrasound probe 500 can be changed according to the actual application, as long as the purpose is achieved, and is not intended to limit the scope of this application.

[0051] The above description of the female reproductive system is for illustrative purposes only and is not intended to limit the scope of this application. Those skilled in the art can make various changes and modifications based on the description in this application. For example, the structure, shape, size, etc., of one or more parts of the female reproductive system may differ for different users. These changes and modifications still fall within the protection scope of this application.

[0052] In some embodiments of this specification, a visual puncture oocyte retrieval needle is provided, which may include a needle tube, the needle tube including a distal end and a proximal end, the interior of the needle tube including a cavity, the cavity of the needle tube being open to tissue, the distal end of the needle tube including a needle tip and an ultrasound-enhancing section, the ultrasound-enhancing section being disposed at the rear end of the needle tip; a handle, the handle including a connecting structure and at least two branch tubes, the handle being connected to the proximal end of the needle tube through the connecting structure, the at least two branch tubes being disposed at the proximal end of the handle, the first branch tube of the at least two branch tubes of the handle being connected to a suction tube; an imaging illumination device, the imaging illumination device being connected to the second branch tube of the at least two branch tubes of the handle, the imaging illumination device extending to the distal end of the needle tube through the cavity of the needle tube via the connecting structure.

[0053] Figure 3 This is an exemplary structural schematic diagram of a visual puncture oocyte retrieval needle 100 according to some embodiments of this specification. In some embodiments, see [link to schematic diagram]. Figure 3 The visual puncture oocyte retrieval needle 100 may include a needle tube 110, a handle 120, an imaging illumination device 130, a suction tube 160, and a collection bottle 170.

[0054] The needle 110 can be used for puncture from outside the body into the ovary, and for puncturing target follicles. In some embodiments, the needle may include a proximal end and a distal end. The distal end of the needle includes an ultrasound-enhancing segment, which is disposed around the periphery of the distal end of the needle. In this specification, unless otherwise specified, the end of each component closer to the operator (e.g., a physician) during operation (e.g., puncture) is the proximal end, and the end farther from the operator is the distal end. The handle and the distal and proximal ends of the imaging illumination device are oriented in the same direction as the distal and proximal ends of the needle. Figure 3 As shown, the end of the needle tube 110 near the handle 120 can be considered the proximal end of the needle tube, and the end of the needle tube 110 away from the handle 120 can be considered the distal end of the needle tube. In some embodiments, the distal end of the needle tube 110 may include a needle tip 111. In some embodiments, the needle tip and the needle tube may be integrated or designed separately. In some embodiments, the proximal end of the needle tube 110 may be connected to the distal end of the handle 120.

[0055] In some embodiments, the interior of the needle tube may include a cavity, the distal end of which is open to tissue. In some embodiments, the cavity enclosed inward by the needle tube wall of the needle tube 110 may be a cavity open to tissue, with the needle tube wall contacting tissue (e.g., ovary, skin) outward. In some embodiments, an imaging illumination device 130 may be inserted into the cavity of the needle tube 110. In some embodiments, the imaging illumination device 130 may extend from the distal end of the cavity of the needle tube 110.

[0056] In some embodiments, the needle 110 may be made of a rigid material. For example, the needle may be made of stainless steel. In some embodiments, the length of the needle 110 may include various specifications, depending on the method of use and the scenario. The method of use may include vaginal egg retrieval and / or abdominal egg retrieval. Due to the different puncture sites and the distance between the puncture site and the ovary, the required needle length for the egg retrieval needle differs in vaginal egg retrieval and / or abdominal egg retrieval. In some embodiments, the length of the needle 110 may vary depending on the patient's physiological structure. The patient's physiological structure may include the location of the ovaries, body size, etc. In some embodiments, the length of the needle 110 may not exceed 50 cm. In some embodiments, the length of the needle 110 may not exceed 40 cm. In some embodiments, the length of the needle 110 may not exceed 38 cm. In some embodiments, the length of the needle 110 may not exceed 35 cm.

[0057] In some embodiments, the length of the needle tube 110 extending from the handle 120 can be varied. For example, the needle tube 110 can be a telescopic structure, a sheath structure, a spring structure, etc. In some embodiments, after the needle tube reaches the target position, it can be locked by a manual locking mechanism or an automatic locking mechanism to maintain the needle tube length during operation. In some embodiments, the manual locking mechanism of the needle tube may include a knob, a lever, or other manual device. In some embodiments, the automatic locking mechanism of the needle tube may include a sensor. The sensor detects the position of the needle tube extension and retraction and automatically locks it when needed. For example, a dwell time threshold can be set; when the position of the needle tube extension and retraction remains relatively stable within the dwell time threshold, the automatic locking mechanism of the needle tube automatically locks.

[0058] In some embodiments of this specification, the length of the needle is set to be variable, providing flexibility while ensuring structural stability and safety through a locking mechanism. Because of the variable length, it can be used in vaginal and / or abdominal egg retrieval, and the appropriate length can be determined for different patients' physiological structures, thus broadening its application scenarios.

[0059] Figure 4This is an exemplary enlarged structural schematic diagram of the distal end of a visual puncture oocyte retrieval needle according to some embodiments of this specification. In some embodiments, the distal end of the needle tube 110 may include a needle tip 111 and an ultrasound-enhancing section 112. In some embodiments, the ultrasound-enhancing section may be used to mark the position of the needle tip of the puncture needle tube. The ultrasound-enhancing section 112 is used to highlight the position of the needle tip of the puncture needle tube in an image displayed on a monitor. Figure 4 As shown, the ultrasonic imaging section 112 can be arranged circumferentially around the outer periphery of the puncture needle tube along the outer wall of the needle tube. In some embodiments, the ultrasonic imaging section 112 is located at the rear end of the needle tip. In some embodiments, the ultrasonic imaging section 112 can be a coating and / or an etched structure. In some embodiments, the coating material can be a material that enhances or effectively transmits sound waves.

[0060] The ultrasound imaging segment enhances the imaging of the oocyte retrieval needle in the ultrasound-guided device, helping the operator to accurately locate the needle tip and ensuring the safety and effectiveness of the procedure.

[0061] The handle can be the part used to manipulate, control, or hold a visual percutaneous oocyte retrieval needle for operation. In some embodiments, the handle 120 may include a connection structure and at least two branch tubes.

[0062] In some embodiments, the distal end of the handle 120 can be connected to the proximal end of the needle tube 110 via the connection structure 121. In some embodiments, the proximal end of the handle 120 can be connected to at least the imaging illumination device 130 and / or the suction tube 160.

[0063] In some embodiments, the handle may be hollow and may include an inner cavity 126. When the needle and the handle are connected, the inner cavity of the handle and the cavity of the needle may communicate with each other.

[0064] In some embodiments, the handle can be made of a rigid material. In some embodiments, the handle can be made of a polymer material. For example, the handle can be made of PE, PP, ABS, etc.

[0065] In some embodiments, the connection structure may be, but is not limited to, threaded connections, snap-fit ​​connections, sleeve connections, etc. The cross-section of the connection structure may be a section perpendicular to the direction of needle extension, such as... Figure 3 The cross section A-A' in this application specification. Unless otherwise specified, the cross section can refer to the section perpendicular to the axial extension direction of the needle tube.

[0066] In some embodiments, at least two branch tubes are disposed at the proximal end of the handle. In some embodiments, the at least two branch tubes and the connecting structure are integrally formed. In some embodiments, the ports of the at least two branch tubes can be connected to the imaging illumination device 130 and the suction tube 160, respectively. The at least two branch tubes may include at least a first branch tube and a second branch tube. In some embodiments, the first branch tube may be parallel to the axial direction of the needle tube, and the second branch tube is at an angle to the first branch tube, wherein the angle between the second branch tube and the first branch tube may be a non-obtuse angle. In some embodiments, the first branch tube is connected to the suction tube, and the second branch tube is connected to the imaging illumination device.

[0067] Figure 6 This is a perspective view of an exemplary handle of a visual puncture oocyte retrieval needle according to some embodiments of this specification. Figure 6 As shown, the handle 120 may include a connecting structure 121 and two branch tubes at a certain angle, namely a second branch tube 122 and a first branch tube 123. The distal end of the connecting structure 121 is connected to the proximal end of the needle tube 110. The distal ends of the second branch tube 122 and the first branch tube 123 converge at the connecting structure 121. The proximal end of the second branch tube 122 is connected to the imaging illumination device 130 through a displacement adjustment device 140, and the first branch tube 123 is connected to the suction tube 160.

[0068] The infusion tubing can be a conduit for injecting the infusion fluid. The infusion fluid may include flushing fluid and / or medication.

[0069] In some embodiments, the number of branch pipes can be three, including a first branch pipe, a second branch pipe, and a third branch pipe. For example... Figure 7 As shown, the port of each branch tube is connected to at least one of the infusion tube 150, the imaging illumination device 130, and the suction tube 160. In some embodiments, the first branch tube is connected to the suction tube, the second branch tube is connected to the imaging illumination device, and the port of the third branch tube is connected to the infusion tube. A detailed description of the handle containing the three branch tubes can be found in [reference needed]. Figures 7-9 The corresponding explanatory content.

[0070] In some embodiments, the second branch tube of the handle may include at least one bypass interface, one of which is connected to the infusion tube, the infusion tube extending through the bypass interface into the cavity of the syringe. For example... Figure 10 As shown, the second branch tube connected to the imaging illumination device 130 may include a bypass interface, wherein the bypass interface is connected to the infusion tube 150. A detailed description of the handle including the bypass interface can be found in [reference needed]. Figures 10-13 The corresponding instructions state that the infusion tubing can enter the corresponding branch tubing via at least one bypass interface and extend into the cavity of the syringe.

[0071] In some embodiments, the infusion tube may be made of a flexible material. For example, the infusion tube may be made of PVC.

[0072] Through some embodiments described in this specification, during the puncture stage, injecting perfusion fluid into the infusion tube can expand the cavity wall of the tissue and clean away interference around the needle, ensuring that the imaging device can obtain clear images; during the oocyte retrieval stage, injecting perfusion fluid into the infusion tube can flush the follicles and improve the oocyte retrieval rate.

[0073] A suction tube can refer to a tube used for oocyte collection. In some embodiments, the proximal end of the suction tube is connected to a collection bottle. In some embodiments, the axial direction of the first branch tube communicating with the suction tube is the same as the axial direction of the needle tube. In some embodiments, perfusion fluid, follicular fluid, and other bodily fluids can also be introduced into the collection bottle through the suction tube.

[0074] In some embodiments, follicular fluid can be transferred to a collection bottle via a suction cavity. The suction cavity can refer to the cavity through which the follicular fluid is aspirated before entering the collection bottle. In some embodiments, the suction tube can enter through the port of the first branch tube of the handle and extend into the cavity of the needle. In some embodiments, the suction cavity can be the lumen within the suction tube. In some embodiments, the suction tube includes a distal portion and a proximal portion. In some embodiments, the distal portion of the suction tube can refer to the portion of the suction tube placed in the needle during the egg retrieval procedure. In some embodiments, the proximal portion of the suction tube can refer to the portion of the suction tube placed in the handle during the egg retrieval procedure and the portion extending out of the handle from the proximal port of the handle.

[0075] In some embodiments, the suction tube may be connected to the handle and the needle. In some embodiments, the distal portion of the suction tube may be connected to the proximal port of the first branch tube of the handle. In some embodiments, the port of the suction tube may be sleeved on the port of the first branch tube of the handle. In some embodiments, since the suction tube is sleeved on the port of the first branch tube, the suction tube does not extend into the needle, and the inner cavity of the handle and the cavity of the needle are connected to form a suction cavity. In some embodiments, the suction cavity may include the cavity between the needle wall of the needle and the infusion tube and / or the imaging illumination device. For details, please refer to this specification. Figure 8-9 The relevant descriptions in sections 12-13. In some embodiments, the oocyte can pass through the suction cavity into the suction tube and finally into the collection bottle.

[0076] In some embodiments, the suction tube may be made of the same material as the infusion tube.

[0077] A collection bottle can refer to a bottle used to collect follicular fluid. In some embodiments, when the needle of the oocyte retrieval needle is inserted into the target location (mature follicle), the follicular fluid can enter the collection bottle through an aspiration tube. The collection bottle can be connected to a negative pressure device (negative pressure pump or negative pressure aspirator). Activating the negative pressure device allows negative pressure to be transmitted to the tip of the needle through the aspiration chamber. Thus, during ovarian puncture, the follicular fluid can be aspirated into the collection bottle. In some embodiments, the collection bottle inlet has a screening structure, such as a screening mesh, to remove some impurities before the follicular fluid enters the collection bottle. The screening structure can be replaceable, for example, by having a replacement slot on the side of the collection bottle.

[0078] The description of the aspiration tube and collection bottle above is for illustrative purposes only and is not intended to limit the scope of this application. Those skilled in the art can make various changes and modifications based on the description in this application. For example, if the interface of the path through which the follicular fluid passes connects two components of different sizes (e.g., a needle, a handle, an aspiration tube, etc.), some bevels can be provided at the interface to facilitate the oocytes entering the collection bottle along the aspiration cavity. These changes and modifications are still within the protection scope of this application.

[0079] An imaging illumination device can refer to a device that provides real-time image guidance during operation. In some embodiments, the distal end of the imaging illumination device can be an imaging illumination fiber, and it can include a lens and an illumination device that partially or completely surrounds the lens. The imaging illumination fiber can contain an electron mirror or an optical mirror.

[0080] In some embodiments, the imaging illumination device is connected to the second branch tube of at least two branch tubes of the handle, and extends through the cavity of the needle tube to the distal end of the needle tube via a connecting structure.

[0081] In some embodiments, the imaging illumination device is provided with a displacement adjustment device to adjust the length of the imaging illumination device extending into and out of the needle tube (i.e., the extension length of the imaging illumination device). For example... Figure 3 As shown, the imaging illumination device 130 can be connected to the second branch pipe 130 via the displacement adjustment device 140. The connection method can include threaded connection or snap-fit. In some embodiments, the imaging illumination device 130 is connected to the movable end of the displacement adjustment device 140. After adjusting the imaging illumination device 130 to a suitable position, the extension length of the imaging illumination device 130 is fixed by the imaging displacement adjustment device 140.

[0082] In some embodiments, the imaging illumination device can extend from the needle tip via a displacement adjustment device. During the puncture procedure, the operator can insert the imaging illumination device into the needle via a second branch tube, without it extending from the needle tip.

[0083] In some embodiments, the imaging illumination device may include an optical imaging device and / or an electronic imaging device.

[0084] To more clearly determine the positional relationship between the infusion tube, imaging illumination device, and suction tube within the syringe, please refer to [references to be inserted here]. Figure 3-6 , Figure 7-9 , Figure 10-14 .

[0085] When there are two branch cannulas, details regarding the visual puncture oocyte retrieval needle 100 can be found in [link to documentation]. Figure 3 , Figure 5 , Figure 6 Related explanations.

[0086] Figure 3 This is an exemplary schematic diagram of a visual puncture oocyte retrieval needle according to some embodiments of this specification. Figure 5 This is a perspective view of the distal end of an exemplary needle tube of a visual puncture oocyte retrieval needle according to some embodiments of this specification. Figure 6 This is a perspective view of an exemplary handle of a visual puncture oocyte retrieval needle according to some embodiments of this specification. Figure 5 and Figure 6 They are Figure 3 A perspective view of the syringe and handle.

[0087] In some embodiments, when the handle includes two branch tubes, the first branch tube is connected to the suction tube, and the second branch tube is connected to the imaging illumination device via a displacement adjustment device. For example... Figure 3 , Figure 6 As shown, the handle 120 of the visual puncture oocyte retrieval needle 100 includes a connecting structure 121, a first branch tube 123 and a second branch tube 122. The second branch tube 122 is connected to the imaging illumination device 130 through a displacement adjustment device 140, and the first branch tube 123 is connected to the suction tube 160.

[0088] like Figure 5 , Figure 6 As shown, when the imaging illumination device 130 enters the needle tube 110, the suction cavity 1601 can be the cavity between the inner wall of the needle tube and the imaging illumination device, that is, the suction cavity 1601 can be the space in the cavity of the needle tube excluding the imaging illumination device. In some embodiments, the suction cavity 1601 also includes the inner cavity of the handle 120. Follicular fluid can pass through the suction cavity 1601 into the suction tube 160 and finally into the collection bottle 170.

[0089] The usage of the visual puncture oocyte retrieval needle 100 includes:

[0090] Step 11, Assemble the imaging illumination device. The imaging illumination device is inserted through the port of the second branch tube. Specifically, the imaging illumination fiber at the distal end of the imaging illumination device enters through the port of the second branch tube, passes through the handle's connecting structure, and further extends through the cavity of the needle tube to the distal end of the needle tube, but does not protrude from the distal end of the needle tube (e.g., Figure 5 (As shown).

[0091] Step 12, Assemble the suction tube. In some embodiments, connect the suction tube to the first branch tube. In some embodiments, fit the end of the suction tube onto the end of the first branch tube. In some embodiments, the suction tube may enter through the end of the first branch tube, extend into the cavity of the needle, and not protrude from the distal end of the needle.

[0092] Step 13, Assemble the collection bottle. Connect the collection bottle to the suction tube and the negative pressure device (negative pressure pump or negative pressure suction device).

[0093] Step 14: Locate the puncture point and perform the puncture. Use a visual puncture needle to perform the puncture through the puncture point. Guided by the imaging illumination device and / or the monitor corresponding to the ultrasound guidance device, insert the visual puncture needle into the target location (e.g., mature follicle) through the puncture site. The operator can obtain a suitable field of view through the imaging illumination device and the ultrasound guidance device, and directly visualize the position of the puncture needle and the surrounding tissue on the monitor connected to the ultrasound guidance device (e.g., B-ultrasound) and the monitor connected to the imaging illumination device. Activate the negative pressure device; negative pressure is transmitted to the distal end of the visual puncture needle, and the follicle is attracted to the distal end of the needle, allowing the operator to puncture the target follicle. During the puncture, adjust the position of the visual puncture needle in real time under direct vision to accurately puncture the target location (target follicle).

[0094] Step 15: Collect the target material (e.g., follicular fluid from oocytes).

[0095] Once the negative pressure device is activated, negative pressure is transmitted to the distal end of the needle through the suction chamber, allowing follicular fluid (including oocytes) to be aspirated into the collection bottle. After the negative pressure device is turned on, the follicular fluid can enter the suction chamber through the distal end of the visual puncture needle and eventually enter the collection bottle.

[0096] In some embodiments, the imaging illumination fiber can extend from the needle tip of the needle tube. The operator can use a displacement adjustment device to move the imaging illumination fiber axially within the needle tube of the egg retrieval needle until the distal end of the imaging illumination device is located in a suitable position within the needle tube near the puncture head, and then tighten and lock it to fix this relative position.

[0097] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as the combination of these technical features does not contradict each other, it should be considered to be within the scope of this specification. For example, in the above embodiments, the suction tube enters through one port of at least two branch tubes of the handle and extends into the cavity of the needle tube. The suction cavity may include the inner cavity of the suction tube that extends forward through the port of the first branch tube of the handle into the cavity of the needle tube.

[0098] When the number of branch cannulas is 3, detailed information on the 200mm visual puncture oocyte retrieval needle can be found in [link to documentation]. Figures 7-9 Related explanations.

[0099] Figure 7 This is yet another specific schematic diagram of an exemplary visual puncture oocyte retrieval needle shown in some embodiments of this specification. Figure 8 This is yet another perspective view of the distal end of an exemplary needle tube of a visual puncture oocyte retrieval needle shown in some embodiments of this specification. Figure 9 This is yet another perspective view of an exemplary handle of a visual puncture oocyte retrieval needle shown in some embodiments of this specification. Figure 8 and Figure 9 They are Figure 7 A perspective view of the syringe and handle.

[0100] In some embodiments, when the handle 120 includes three branch tubes, the first branch tube is connected to the suction tube, the second branch tube is connected to the imaging illumination device via a displacement adjustment device, and the port of the third branch tube is connected to the infusion tube. Figure 7 , Figure 9 As shown, the handle 120 of the visual puncture oocyte retrieval needle 200 includes a connecting structure 121 and three branch tubes, namely a first branch tube 123, a second branch tube 122, and a third branch tube 124. The second branch tube 122 is connected to the imaging illumination device 130 through a displacement adjustment device 140, the first branch tube 124 is connected to the suction tube 160, and the third branch tube 123 is connected to the infusion tube 150.

[0101] In some embodiments, such as Figure 8 As shown, the imaging illumination device 130 and the infusion tube 150 are arranged side by side within the cavity of the needle tube 110. In some embodiments, the length of the infusion tube 150 within the needle tube may be less than the length of the imaging illumination device 130 within the needle tube.

[0102] like Figure 8As shown, after the infusion tube 150 and the imaging illumination device 130 enter the needle tube 110, the suction cavity 1601 can be the cavity between the inner wall of the needle tube and the imaging illumination device 130 and the infusion tube 150, that is, the suction cavity 1601 can be the space in the cavity of the needle tube excluding the imaging illumination device and the infusion tube. In some embodiments, the suction cavity 1601 may also include the inner cavity of the handle 120. Follicular fluid can pass through the suction cavity 1601 into the suction tube 160 and finally into the collection bottle 170.

[0103] The technical features of the above embodiments can be combined arbitrarily. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as the combination of these technical features does not contradict each other, it should be considered within the scope of this specification. For example, in the above embodiments, the suction tube enters through one of the proximal ports of at least two branch tubes of the handle and extends into the cavity of the needle tube. The suction cavity may include the inner cavity of the suction tube that extends forward through the proximal ports of at least two branch tubes of the handle into the cavity of the needle tube.

[0104] The usage of the visual puncture oocyte retrieval needle 200 includes:

[0105] Step 21: Assemble the imaging illumination device. See Step 11.

[0106] Step 22, Assemble the suction tube. See step 12.

[0107] Step 23, Assemble the collection bottle. See Step 13.

[0108] Step 24, assemble the infusion tubing. After the infusion tubing enters through the port of the third branch tubing, it reaches the cavity of the needle tube and does not extend from the distal end of the needle tube.

[0109] Step 25: Locate the puncture point and perform the puncture. See step 14.

[0110] Step 26: Collect oocytes, see step 15.

[0111] Step 27: During the puncture and oocyte collection process, the perfusion fluid is administered through the perfusion tube. Figure 7-9 Taking the visual puncture oocyte retrieval needle 200 shown as an example, in addition to the above... Figure 3-6 In the usage of the magnetic oocyte retrieval needle 100 with a viewing window, due to the addition of an infusion tube, perfusion fluid can be injected into the infusion tube during the puncture process to expand the cavity wall of the tissue and clean the interference around the needle, ensuring that the imaging device can obtain a clear image; during the oocyte retrieval stage, the follicles can be flushed by injecting perfusion fluid into the infusion tube, thereby improving the oocyte retrieval rate.

[0112] When there are two branch cannulas, and the second branch cannula includes at least one bypass interface, details regarding the 300mm visual puncture oocyte retrieval needle can be found in [link to documentation]. Figure 10-13 Related explanations.

[0113] Figure 10 This is yet another specific schematic diagram of an exemplary visual puncture oocyte retrieval needle shown in some embodiments of this specification. Figure 11 This is yet another perspective view of the distal end of an exemplary needle tube of a visual puncture oocyte retrieval needle shown in some embodiments of this specification. Figure 12 This is a schematic cross-sectional view of the distal end of an exemplary needle tube of a visual puncture oocyte retrieval needle according to some embodiments of this specification. Figure 13 This is yet another perspective view of an exemplary handle of a visual puncture oocyte retrieval needle shown in some embodiments of this specification. Figure 11-12 They are Figure 10 The diagram shows the corresponding needle and handle.

[0114] In some embodiments, the second branch tube of the handle may include at least one bypass interface, one of which may be connected to an infusion tube that extends through the bypass interface into the cavity of the syringe. Figure 10 , Figure 13 As shown, the handle 120 of the visual puncture oocyte retrieval needle 200 includes a connecting structure 121, a second branch tube 122, and a first branch tube 123. The second branch tube 122 includes a bypass interface 125. The second branch tube 122 is connected to the imaging illumination device 130 through a displacement adjustment device 140. The bypass interface 125 is connected to the infusion tube 150. The first branch tube 123 is connected to the suction tube 160.

[0115] In some embodiments, such as Figure 11 As shown, the imaging illumination device 130 passes through the lumen of the infusion tube 150 and extends along the lumen of the infusion tube 150 to the distal end of the needle tube 110. In some embodiments, the length of the infusion tube 150 within the needle tube may be less than the length of the imaging illumination device 130 within the needle tube.

[0116] like Figure 11 As shown, after the infusion tube 150 and the imaging illumination device 130 enter the needle tube 110, the suction cavity 1601 can be the cavity between the inner wall of the needle tube and the infusion tube 150, that is, the suction cavity 1601 can be the space in the cavity of the needle tube excluding the infusion tube. In some embodiments, the suction cavity 1601 also includes the inner cavity of the handle 120 (e.g., Figure 6 (The inner cavity 126). Follicular fluid can pass through the suction cavity 1601 into the suction tube 160 and finally into the collection bottle 170.

[0117] The usage method of the visual puncture oocyte retrieval needle 300 can be found in the usage method of the visual puncture oocyte retrieval needle 200. The difference is that when assembling the imaging illumination device and the infusion tube, the imaging illumination device can be inserted into the lumen of the infusion tube and extend along the lumen of the infusion tube to the distal end of the needle tube.

[0118] In some embodiments, the needle tube 110 may be a double-layered structure. In this case, the lumen of the inner tube is the cavity of the needle tube. Figure 14 This is a schematic diagram of the distal end of the visual puncture oocyte retrieval needle during the puncture process, as shown in some embodiments of this specification. Figure 16 This is another structural schematic diagram of the distal end of the visual puncture oocyte retrieval needle during the oocyte retrieval process, as shown in some embodiments of this specification. For example... Figure 14 As shown, based on the visual puncture oocyte retrieval needle 100-300, the needle tube 110 may include an inner tube 1111 and an outer tube 1101 that are open to the tissue. The ultrasound-detectable segment is located at the distal end of the outer tube. The distal end of the inner tube 1111 has a needle tip 111 for puncture, and the distal end of the outer tube is a flat end. In some embodiments, the extension lengths of both the inner tube 1111 and the outer tube 1101 can be varied. The extension length of the inner tube may refer to the length of the inner tube extending beyond the handle. The extension length of the outer tube may refer to the length of the outer tube extending beyond the handle. In some embodiments, the extension lengths of the inner and outer tubes can be controlled separately by the inner tube moving device and the outer tube moving device of the handle. In some embodiments, the inner tube moving device and the outer tube moving device can be knobs. The inner tube moving knob and the outer tube moving knob correspond to the threads on the outer circumference of the inner tube and the outer tube, respectively. By rotating the inner tube moving knob and / or the outer tube moving knob, the inner tube and / or the outer tube can move back and forth along their axial direction, thereby changing the extension length of the inner tube and / or the outer tube. In this specification, the inner tube moving device and the outer tube moving device are not limited, as long as they can change the extension length of the inner tube and the outer tube.

[0119] In some embodiments, the inner tube and the outer tube can also rotate relative to each other via an inner tube moving device and an outer tube moving device. In some embodiments, the inner tube moving device can control the extension length of the inner tube, and the outer tube moving device can control the rotation of the outer tube around the inner tube, or vice versa. In some embodiments, the inner tube moving device and the outer tube moving device can be provided with at least one position corresponding to different extension lengths and rotation positions of the inner tube and the outer tube.

[0120] In some embodiments, a locking hole 1102 is provided on the distal sidewall of the outer tube 1101. The locking hole 1102 can communicate with the cavity of the needle tube (i.e., the lumen of the inner tube), and the target substance can enter the cavity of the needle tube through the locking hole 1102. The diameter of the locking hole 1102 can be less than or equal to the diameter of the bevel of the needle tip. During puncture of the ovary or skin, the extension length of the inner tube with the needle tip is greater than the extension length of the outer tube, allowing the needle tip to smoothly puncture and reach the target location (mature follicle) or its vicinity. Because the locking hole is on the sidewall, other tissues will not enter the cavity of the needle tube through the locking hole. After the puncture, during the follicular fluid retrieval process, rotate the inner tube movement knob and / or the outer tube movement knob to ensure the inner tube extends beyond the outer tube. Adjust the position of the imaging illumination device so that the imaging illumination fiber retracts along the proximal end of the inner tube, ensuring it does not obstruct the entry of follicular fluid. At this point, the follicular fluid can enter the cavity of the visual puncture needle tube through the locking hole 1102. During the retraction of the imaging illumination fiber, turn off the light source output of the illumination component to prevent high-intensity illumination light from directly irradiating the oocytes, effectively preventing photochemical reactions from damaging the cell membrane structure and cytoplasmic components. In this specification, other methods can also be used to reduce light damage to oocytes, such as infrared mode.

[0121] In some embodiments, the distal end of the outer tube 1101 is provided with an opening and closing mechanism 1103. The opening and closing mechanism 1103 includes at least one hinge 1104 and a corresponding number of leaf flaps 1105. The leaf flaps can be made of biocompatible materials. For example, the leaf flap material may include medical-grade silicone, polyether block amide, etc. In some embodiments, the leaf flap surface has a hydrophilic coating. Figure 17 This is a schematic diagram of an exemplary structure of the distal end of the outer tube as shown in some embodiments of this specification. Figure 17 As shown, there can be six leaflets 1105. Each leaflet 1105 is connected to the distal end of the outer tube 1101 via a hinge 1104, allowing it to open and close. When the extension length of the inner tube 1111 is greater than that of the outer tube, the leaflets 1105, supported by the inner tube 1111, are in the open state. In this open state, the leaflets 1105 adhere to the outer wall of the inner tube 1111, preventing tissue contamination of the puncture needle during the puncture process. For example, it prevents tissue from entering between the outer and inner tubes, increasing the resistance to relative movement between them. When the leaflets 1105 are in the closed state, all leaflets can seal the distal end of the outer tube 1101. When follicular fluid is retrieved, most of the suction negative pressure is transmitted to the locking hole 1102 of the outer tube 1101, rather than concentrating at the distal end of the outer tube.

[0122] like Figure 14As shown, during the puncture, an inner tube moving device (not shown) is used to extend the inner tube 1111 beyond the outer tube 1101. At this point, because the inner tube 1111 extends from the lumen of the outer tube 1101, the flaps 1105 of the outer tube 1101 open, and then the needle tip 111 of the inner tube 1111 is used for puncture. At this time, the imaging illumination device 130 is located within the lumen of the inner tube 1111, enabling visual puncture. After puncturing into the ovary, the needle is further punctured into the target location (mature follicle).

[0123] like Figure 15 As shown, further, by rotating the inner tube moving device or the outer tube moving device, the extension length of the inner tube 1111 is made less than the extension length of the outer tube 1101, ensuring that the needle tip of the inner tube is located between the distal end of the outer tube and the locking hole. The outer tube and / or the inner tube are then rotated so that the beveled opening of the inner tube needle tip faces the locking hole 1102. At this time, the extension length of the inner tube 1111 is less than the extension length of the outer tube 1101, and the hinge 1104 of the opening and closing mechanism 1103 lacks the support of the inner tube 1111, remaining in a closed state. Subsequently, the position of the mature oocyte is determined by the imaging illumination device, and the needle is moved so that the locking hole at the distal end of the needle approaches the mature oocyte. Further, the position of the imaging illumination device is adjusted from the proximal end of the inner tube to the proximal end of the needle by the displacement adjustment device. Figure 17 As shown, when the negative pressure device is activated, the hinges of the opening and closing mechanism are closed, and the negative pressure is mainly concentrated at the locking hole 1102 of the outer tube 1101. At this time, the follicular fluid (including oocyte fluid) enters the lumen of the inner tube through the locking hole 1102 and then enters the collection bottle. Before activating the negative pressure device, the inner or outer tube is rotated by the inner tube moving device or the outer tube moving device, so that the beveled opening of the inner tube needle tip is opposite to the locking hole, and the needle tip is located between the port of the outer tube and the locking hole. Therefore, the follicular fluid does not pass through the needle tip of the inner tube, but directly enters the lumen of the inner tube and then enters the collection bottle. This reduces the accidental damage to the oocyte by the needle tip when the follicular fluid passes through the needle tip. During puncture, the flaps open, allowing the puncture needle to extend; during aspiration, they close to form a negative pressure focus, dynamically adapting to the needs of different operation stages.

[0124] Figure 16 Another embodiment of the visual puncture oocyte retrieval needle described in this specification is shown. For example... Figure 16As shown, when the puncture reaches the target location (mature follicle), the positioning hole is opposite to the mature follicle. The moving device (not shown) of the inner tube 1111 is rotated, and the extension length of the inner tube 1111 is less than the extension length of the outer tube 1101. This causes the needle tip of the inner tube to align with the position behind the positioning hole (closer to the operator), and the extension length of the imaging illumination device is reduced axially, leaving the surface of the positioning hole 1102 of the outer tube 1101 unobstructed. At this time, because the extension length of the inner tube 1111 is less than the extension length of the outer tube 1101, the hinge 1104 of the opening and closing mechanism 1103 lacks support and is in a closed state, as... Figure 17 As shown, when the negative pressure device is activated, the negative pressure is mainly concentrated at the locking hole 1102 of the outer tube 1101. Furthermore, activating the negative pressure device allows the suction negative pressure to be transmitted along the needle tube through the suction chamber, thereby attracting the target follicle. Some follicles will then be locked into the locking hole 1102 of the outer tube 1101. In the field of view of the imaging illumination device, the inner tube with the needle tip moves axially along the needle tube towards the distal end, piercing the target follicle. The follicular fluid is then drawn into the collection bottle through the lumen of the inner tube.

[0125] The oocyte retrieval needle provided in this manual allows the inner tube to extend fully during puncture, while the suction path (positioning hole) is blocked by the outer tube flaps; during aspiration, the inner tube retracts, exposing the positioning hole, thus separating the two paths in time and space, improving the integration and efficiency of the oocyte retrieval needle.

[0126] The technical features described in the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as the combination of these technical features does not contradict each other, it should be considered to be within the scope of this specification. For example, the double-layer structure can be applied to the visual puncture oocyte retrieval needle 100-300, and the corresponding usage method can also refer to the usage method of the visual puncture oocyte retrieval needle 100-300.

[0127] In some embodiments of this application, an egg retrieval device is also provided, including the visual puncture egg retrieval needle and collection bottle mentioned in this application, and further including an egg stripping device.

[0128] The egg-removing device can be an egg-removing needle, used to remove the attached material such as granulosa cells and cumulus cells around the egg cell. In some embodiments, hyaluronidase can be added during the egg-removing step.

[0129] In some embodiments, oocytes obtained can be cultured using a microfluidic culture chip to maintain the in vitro culture of mature oocytes, or immature oocytes can be cultured to maturity in vitro.

[0130] In some embodiments, after oocyte detachment, the oocytes can be further used for detection of viability, culture, fertilization, or freezing. In some embodiments, viability can be detected using a kit.

[0131] The technical features of the above embodiments can be combined arbitrarily. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as the combination of these technical features does not contradict each other, it should be considered within the scope of this specification. For example, in the above embodiments, the suction tube enters through the proximal port of the first branch tube of the handle and extends into the cavity of the needle tube. The suction cavity may include the lumen of the suction tube that extends forward from the proximal port of the first branch tube of the handle into the cavity of the needle tube. Furthermore, the egg retrieval needle of this application may also have other applications, and the embodiments of this application are not intended to limit it.

[0132] It should be noted that different embodiments may produce different beneficial effects. In different embodiments, the beneficial effects may be any one or a combination of the above, or any other possible beneficial effects. For example, the surface of the needle tube, imaging illumination device, opening and closing mechanism, infusion tube, suction tube and other components of the visual puncture oocyte retrieval needle may be coated with a hydrophilic coating.

[0133] The basic concepts have been described above. Obviously, for those skilled in the art, the detailed disclosure above is merely illustrative and does not constitute a limitation of this specification. Although not explicitly stated herein, those skilled in the art may make various modifications, improvements, and corrections to this specification. Such modifications, improvements, and corrections are suggested in this specification and therefore remain within the spirit and scope of the exemplary embodiments described herein.

[0134] Furthermore, this specification uses specific terms to describe embodiments thereof. For example, "an embodiment," "one embodiment," and / or "some embodiments" refer to a particular feature, structure, or characteristic associated with at least one embodiment of this specification. Therefore, it should be emphasized and noted that references to "an embodiment," "one embodiment," or "an alternative embodiment" in different locations throughout this specification do not necessarily refer to the same embodiment. Moreover, certain features, structures, or characteristics in one or more embodiments of this specification can be appropriately combined.

[0135] Furthermore, unless expressly stated in the claims, the order of processing elements and sequences, the use of numbers and letters, or other names described in this specification are not intended to limit the order of the processes and methods described herein. Although various examples have been discussed in the foregoing disclosure of embodiments that are currently considered useful, it should be understood that such details are for illustrative purposes only, and the appended claims are not limited to the disclosed embodiments; rather, the claims are intended to cover all modifications and equivalent combinations that conform to the substance and scope of the embodiments described herein. For example, while the system components described above can be implemented using hardware devices, they can also be implemented solely using software solutions, such as installing the described system on existing servers or mobile devices.

[0136] Similarly, it should be noted that, in order to simplify the descriptions disclosed herein and thus aid in the understanding of one or more embodiments, the foregoing description of embodiments in this specification sometimes combines multiple features into a single embodiment, drawing, or description thereof. However, this method of disclosure does not imply that the subject matter of this specification requires more features than those mentioned in the claims. In fact, the embodiments contain fewer features than all the features of the single embodiments disclosed above.

[0137] In some embodiments, numbers describing the quantity of components and attributes are used. It should be understood that such numbers used in the description of embodiments are modified in some examples with the terms "approximately," "approximately," or "generally." Unless otherwise stated, "approximately," "approximately," or "generally" indicates that the numbers are allowed to vary by ±20%. Accordingly, in some embodiments, the numerical parameters used in the specification and claims are approximate values, which may be changed depending on the characteristics required by individual embodiments. In some embodiments, numerical parameters should take into account specified significant digits and employ a general method of digit reservation. Although the numerical ranges and parameters used to confirm their breadth of range in some embodiments of this specification are approximate values, in specific embodiments, such values ​​are set as precisely as feasible.

[0138] For each patent, patent application, patent application publication, and other material, such as articles, books, specifications, publications, and documents, referenced in this specification, the entire contents of which are incorporated herein by reference. This excludes historical application documents that are inconsistent with or conflict with the content of this specification, as well as documents that limit the broadest scope of the claims in this specification (currently or subsequently appended to this specification). It should be noted that in the event of any inconsistency or conflict between the descriptions, definitions, and / or terminology used in the supplementary materials to this specification and the content of this specification, the descriptions, definitions, and / or terminology used in this specification shall prevail.

[0139] Finally, it should be understood that the embodiments described in this specification are merely illustrative of the principles of the embodiments described herein. Other variations may also fall within the scope of this specification. Therefore, alternative configurations of the embodiments described herein are intended to be illustrative rather than limiting, and should be considered consistent with the teachings of this specification. Accordingly, the embodiments described herein are not limited to those explicitly introduced and described herein.

Claims

1. A visual puncture needle for oocyte retrieval, characterized in that, include: The needle tube includes a distal end and a proximal end, the interior of the needle tube includes a cavity, the cavity of the needle tube is open to tissue, the distal end of the needle tube includes a needle tip and an ultrasound-enhancing section, the ultrasound-enhancing section is located at the rear end of the needle tip; A handle, comprising a connecting structure and at least two branch tubes, wherein the handle is connected to the proximal end of the needle via the connecting structure, the at least two branch tubes are disposed at the proximal end of the handle, and the first branch tube of the at least two branch tubes of the handle is connected to a suction tube. An imaging illumination device is provided, wherein the imaging illumination device is connected to the second branch tube of the at least two branch tubes of the handle, and the imaging illumination device extends to the distal end of the needle tube through the cavity of the needle tube via the connecting structure.

2. The visual puncture oocyte retrieval needle according to claim 1, characterized in that, The suction tube enters through the port of the first branch tube and extends into the cavity of the needle tube.

3. The visual puncture oocyte retrieval needle according to claim 2, characterized in that, The suction cavity is the lumen inside the suction tube.

4. The visual puncture oocyte retrieval needle according to claim 1, characterized in that, The suction tube is fitted onto the port of the first branch pipe.

5. The visual puncture oocyte retrieval needle according to claim 4, characterized in that, The inner cavity of the handle and the cavity of the needle are connected to form a suction cavity.

6. The visual puncture oocyte retrieval needle according to claim 1, characterized in that, The number of branch tubes is three, and the handle also includes a third branch tube. The port of the third branch tube is connected to the infusion tube, and the infusion tube extends into the cavity of the needle tube through the port of the third branch tube.

7. The visual puncture oocyte retrieval needle according to claim 1, characterized in that, The second branch tube includes at least one bypass interface, one of which is connected to the infusion tube, which extends through the bypass interface into the cavity of the needle tube.

8. The visual puncture oocyte retrieval needle according to claim 7, characterized in that, The imaging illumination device is inserted into the lumen of the infusion tube and extends along the lumen of the infusion tube to the distal end of the needle.

9. The visual puncture oocyte retrieval needle according to claim 1, characterized in that, The needle tube includes an inner tube and an outer tube. The distal end of the inner tube has a needle tip, and the lumen of the inner tube is the cavity of the needle tube. A locking hole is provided on the distal side wall of the outer tube, and the locking hole is connected to the cavity of the needle tube. The target substance enters the cavity of the needle tube through the locking hole.

Images