A pipeline connection structure for nanomedicine preparation

Abstract

This invention discloses a tubing connection structure for nanomedicine preparation, comprising: at least two inlet tubes; a microfluidic chip having an aqueous solution inlet, a lipid solution inlet, a mixing channel, and a solution outlet; a fluid control unit, each fluid control unit having a fluid channel connected to a corresponding inlet tube and to either the aqueous solution inlet or the lipid solution inlet of the microfluidic chip; a fluid drive unit, each fluid drive unit including two syringes moving in opposite directions, the injection ends of the two syringes respectively connected to the fluid channel of the fluid control unit; the microfluidic chip connected to a sample recovery tube; the sample recovery tube being sequentially connected from the liquid output direction to a dilution phase input tube and a waste product recovery tube; and clamps provided on both the waste product recovery tube and the sample recovery tube. Through the above-mentioned design, this invention effectively ensures the continuity of solution delivery, thereby improving the preparation effect of nanomedicines.

Description

Technical Field

[0001] This utility model relates to the field of nanomedicine preparation, and in particular to a pipeline connection structure for nanomedicine preparation. Background Technology

[0002] In the field of nanomedicine preparation, precise solution mixing based on microfluidic technology is a core process that determines the quality of nanoparticles. Nanomedicines, represented by liposomes and polymer micelles, require precise proportioning and dynamic mixing of lipid-phase solutions (solutions of lipid materials such as phospholipids and cholesterol) and aqueous-phase solutions (drug aqueous solutions) using microfluidic chips to form nanoscale particles with uniform size and stable structure. This process places stringent requirements on fluid control parameters, among which the continuity of solution delivery is a key parameter throughout the entire preparation process.

[0003] Within a microfluidic chip, the mixing effect of the lipid-phase solution and the aqueous-phase solution directly depends on a stable flow field environment. When the solution delivery is interrupted or the flow rate fluctuates, the hydrodynamic equilibrium within the mixing channel is disrupted, leading to flow field turbulence. This turbulence causes uneven nucleation of nanoparticles, resulting in particle agglomeration and widening of particle size distribution, severely affecting the preparation effect of nanomedicines, namely, the particle size uniformity and structural stability of nanomedicines.

[0004] Therefore, a tubing connection structure for nanomedicine preparation is proposed to ensure the continuity of solution delivery and thus improve the preparation effect of nanomedicine. Utility Model Content

[0005] The purpose of this invention is to provide a pipeline connection structure for the preparation of nanomedicines, so as to ensure the continuity of solution delivery and thus improve the preparation effect of nanomedicines.

[0006] To solve the above-mentioned technical problems, this utility model provides a tubing connection structure for nanomedicine preparation, comprising:

[0007] At least two inlet pipes are used to transport the lipid phase solution and the aqueous phase solution, respectively;

[0008] The microfluidic chip has an aqueous solution inlet, a lipid solution inlet, a mixing channel, and a solution outlet.

[0009] A liquid circuit control unit is provided corresponding to the inlet pipe for conveying the lipid phase solution and the aqueous phase solution. Each liquid circuit control unit is provided with a fluid channel. The input end of the fluid channel is connected to the corresponding inlet pipe, and the output end of the fluid channel is connected to the aqueous phase solution inlet or lipid phase solution inlet of the microfluidic chip through a delivery pipe.

[0010] A fluid drive unit is provided in a one-to-one correspondence with the liquid circuit control unit. Each fluid drive unit includes two syringes with opposite directions of movement. The injection ends of the two syringes are respectively connected to the fluid channel of the liquid circuit control unit, and are used to continuously draw the liquid in the inlet tube into the fluid channel of the liquid circuit control unit and push the liquid in the fluid channel into the microfluidic chip.

[0011] The solution outlet of the microfluidic chip is connected to a sample recovery tube;

[0012] The sample recovery tube is connected in sequence to a dilution phase input tube and a waste recovery tube from the liquid output direction; both the waste recovery tube and the sample recovery tube are equipped with tube clamps for controlling the discharge of the mixed solution containing the dilution phase liquid.

[0013] Furthermore, the liquid circuit control unit includes: a liquid circuit integration box and a first one-way valve;

[0014] The liquid circuit integrated box has two first connection structures and two second connection structures;

[0015] The two first connection structures are respectively connected to the inlet pipe and the delivery pipe, and are used as the input end and the output end of the liquid circuit control unit;

[0016] The two second connecting structures are respectively connected to the two syringes;

[0017] The fluid channel is disposed within the liquid circuit integration box and connects the two first connection structures and the two second connection structures;

[0018] The first one-way valve is disposed on the fluid channel to ensure that the input and output of liquid in the fluid channel do not interfere with each other when the two syringes are running alternately in opposite directions.

[0019] Furthermore, the fluid channel includes two first flow channels, two second flow channels, and two sets of connecting flow channels;

[0020] The two first flow channels are respectively connected to the two first connecting structures;

[0021] The two second flow channels are respectively connected to the two second connecting structures;

[0022] One of the two second flow channels is connected to the two first flow channels through a connecting flow channel on the same side; the other of the two second flow channels is also connected to the two first flow channels through a connecting flow channel on the same side; two first one-way valves arranged in opposite directions are arranged on each set of connecting flow channels.

[0023] Furthermore, the end of the first connecting structure has a sterile connector, and the inlet tube and the first connecting structure, as well as the delivery tube and the first connecting structure, are detachably and sealed through the sterile connector.

[0024] Furthermore, the syringe barrel is slidably inserted into the second connecting structure;

[0025] The outer wall of the second connecting structure has an annular elastic protrusion, and when the syringe barrel is inserted into the second connecting structure, the annular elastic protrusion can abut against and fit against the inner wall of the syringe barrel to form a sealing structure.

[0026] Furthermore, the outer wall of the syringe is provided with a telescopic sleeve, and when the syringe performs a suction or pushing action, the plunger of the syringe is always located in the sealed cavity formed between the syringe barrel and the telescopic sleeve.

[0027] Furthermore, the telescopic sleeve includes a hollow sleeve and a sealing sleeve that are integrally formed;

[0028] One end of the hollow sleeve has a flat cut surface, which is fixedly connected to the skirt end face of the syringe;

[0029] The sealing sleeve is disposed at the other end of the hollow sleeve, and the sealing sleeve is sleeved and fixed to the outer wall of the bottom end of the syringe plunger.

[0030] Furthermore, the hollow sleeve is configured as a corrugated pipe.

[0031] Furthermore, each of the conveying pipes is equipped with a second check valve, which is used to prevent cross-contamination of liquids.

[0032] Furthermore, the inlet pipe, liquid circuit control unit, syringe microfluidic chip, delivery pipe, sample recovery pipe, dilution phase input pipe and waste recovery pipe of the pipeline connection structure are connected to form a disposable pipeline consumable.

[0033] Compared with the prior art, the present invention has at least the following beneficial effects:

[0034] By setting up a liquid circuit control unit and a matching fluid drive unit corresponding to the liquid inlet pipe, and by using two syringes with opposite directions of motion to work together, the lipid phase solution and the aqueous phase solution can be delivered without interruption during the alternating aspiration and push of the two syringes. This ensures the continuity of solution delivery and keeps the solution mixed in the microfluidic chip in a stable flow field environment, thereby improving the preparation effect of nanomedicine.

[0035] Furthermore, since the fluid channel of the liquid circuit control unit is directly connected to the inlet pipe and the delivery pipe, the pressure fluctuation and flow error during the fluid delivery process are effectively reduced through standardized pipeline design, ensuring that the two-phase solution is continuously injected into the microfluidic chip in a precise ratio, thereby further improving the preparation effect of nanomedicine.

[0036] Furthermore, a sample recovery tube connected to the microfluidic chip is incorporated, with a dilution phase input tube and a waste recovery tube sequentially connected from the liquid output direction. Both the sample and waste recovery tubes are equipped with clamps to control their on / off states. This allows the mixed solution to flexibly choose its discharge path based on real-time preparation needs. For example, when nanoparticle stabilization is required, the clamp on the waste recovery tube is closed while the clamp on the sample recovery tube is opened, allowing the diluent and mixed solution to dynamically mix within the sample recovery tube before discharge. Conversely, during initial parameter adjustments or equipment malfunctions, the clamp on the waste recovery tube is opened while the clamp on the sample recovery tube is closed, allowing substandard mixed solutions to be directly discharged through the waste recovery tube, thus preventing substandard samples from entering subsequent processes. In short, the precise control of the clamps and the integrated layout of the recovery pipeline provide a foundation for the automated and intelligent processing of the subsequent mixed solution, significantly improving the controllability of the nanomedicine preparation process and reducing the risk of contamination from human intervention. Attached Figure Description

[0037] Figure 1 This is a schematic diagram of the pipeline connection structure for nanomedicine preparation in one embodiment of the present invention;

[0038] Figure 2 This is a partial cross-sectional view of the connection between the liquid circuit control unit and the drive unit in a pipeline connection structure for nanomedicine preparation according to an embodiment of the present invention.

[0039] Figure 3 This is a diagram showing the liquid flow direction within the liquid control unit when the syringe performs an aspiration action in a tubing connection structure for nanomedicine preparation according to one embodiment of the present invention.

[0040] Figure 4 This is a diagram showing the liquid flow direction within the liquid control unit of the syringe performing the pushing action in a tubing connection structure for nanomedicine preparation according to one embodiment of the present invention.

[0041] Figure 5 This is a half-sectional view of the syringe in the tubing connection structure for nanomedicine preparation in one embodiment of the present invention.

[0042] Icon labels:

[0043] 1. Liquid inlet pipe;

[0044] 2. Fluid circuit control unit; 21. Fluid circuit integration box; 211. First connection structure; 212. Second connection structure; 22. Fluid channel; 221. First flow channel; 222. Second flow channel; 223. Connecting flow channel; 23. First check valve;

[0045] 3. Syringe;

[0046] 4. Microfluidic chip;

[0047] 5. Delivery pipe; 51. Second check valve;

[0048] 6. Sample recovery tube;

[0049] 7. Dilution phase inlet pipe;

[0050] 8. Waste recycling pipe;

[0051] 9. Annular elastic protrusions;

[0052] 10. Expansion sleeve; 101. Hollow sleeve; 102. Sealing sleeve;

[0053] 11. Pipe clamp. Detailed Implementation

[0054] The following will describe in more detail the tubing connection structure for nanomedicine preparation according to the present invention with reference to the schematic diagrams, which illustrate preferred embodiments of the present invention. It should be understood that those skilled in the art can modify the present invention described herein while still achieving the advantageous effects of the present invention. Therefore, the following description should be understood as being of general knowledge to those skilled in the art and is not intended to limit the present invention.

[0055] The present invention will be described in more detail below by way of example with reference to the accompanying drawings. The advantages and features of the present invention will become clearer from the following description. It should be noted that the drawings are in a very simplified form and use non-precise proportions, and are only used to facilitate and clarify the illustration of the embodiments of the present invention.

[0056] like Figures 1 to 5 As shown in the figure, this utility model embodiment proposes a tubing connection structure for nanomedicine preparation, comprising:

[0057] At least two inlet pipes 1 are used to transport the lipid phase solution and the aqueous phase solution, respectively.

[0058] The microfluidic chip 4 has an aqueous solution inlet, a lipid solution inlet, a mixing channel, and a solution outlet.

[0059] The liquid circuit control unit 2 is provided in correspondence with the liquid inlet pipe 1 for conveying the lipid phase solution and the aqueous phase solution. Each liquid circuit control unit 2 is provided with a fluid channel 22. The input end of the fluid channel 22 is connected to the corresponding liquid inlet pipe 1. The output end of the fluid channel 22 is connected to the aqueous phase solution inlet or lipid phase solution inlet of the microfluidic chip 4 through a delivery pipe 5.

[0060] A fluid drive unit is configured in a one-to-one correspondence with the liquid path control unit 2. Each fluid drive unit includes two syringes 3 moving in opposite directions. The injection ends of the two syringes 3 are respectively connected to the fluid channel 22 of the liquid path control unit 2, for continuously drawing liquid from the inlet tube 1 into the fluid channel 22 of the liquid path control unit 2 and pushing liquid from the fluid channel 22 into the microfluidic chip 4. That is, by the two syringes 3 alternately performing the drawing and pushing actions, the lipid phase solution and the aqueous phase solution can continuously enter into the fluid channel 22 and continuously exit from the fluid channel 22 into the microfluidic chip 4, thereby effectively ensuring the continuity of solution delivery and improving the preparation effect of nanomedicines.

[0061] In this embodiment, the solution outlet of the microfluidic chip 4 is connected to a sample recovery tube 6 to complete the output of the mixed solution.

[0062] The sample recovery tube 6 is connected in sequence to the dilution phase input tube 7 and the waste recovery tube 8 from the liquid output direction.

[0063] Both the waste recovery tube 8 and the sample recovery tube 6 are equipped with tube clamps 11 for controlling the discharge of the mixed solution containing the diluent phase liquid, so as to selectively adjust the discharge path of the mixed solution as needed.

[0064] When stabilization of nanoparticles is required, the clamp 11 on the waste recovery tube 8 is closed and the clamp 11 on the sample recovery tube 6 is opened, allowing the diluent and the mixed solution to be dynamically mixed in the sample recovery tube 6 before being discharged. When the parameters are adjusted in the initial stage of preparation or the equipment is malfunctioning, the clamp 11 on the waste recovery tube 8 is opened and the clamp 11 on the sample recovery tube 6 is closed, allowing the unqualified mixed solution to be discharged directly from the waste recovery tube 8, thereby preventing unqualified samples from entering the subsequent process.

[0065] In this embodiment, the device is equipped with a liquid circuit control unit 2 corresponding to the liquid inlet pipe 1 and a matching fluid drive unit. The fluid drive unit uses two syringes 3 with opposite directions of movement to work together, so that the lipid phase solution and the aqueous phase solution can be delivered without interruption during the alternating aspiration and push of the two syringes 3. This ensures the continuity of solution delivery, so that the solution mixed in the microfluidic chip 4 is always in a stable flow field environment, thereby improving the preparation effect of nanomedicine.

[0066] Furthermore, since the fluid channel 22 of the liquid circuit control unit 2 is directly connected to the inlet pipe 1 and the delivery pipe 5, the pressure fluctuation and flow error during the fluid delivery process are effectively reduced through standardized pipeline design, ensuring that the two-phase solution is continuously injected into the microfluidic chip 4 in a precise ratio, thereby further improving the preparation effect of nanomedicine.

[0067] In this embodiment, a specific liquid circuit control unit 2 is also proposed to better cooperate with the two syringes 3 to achieve stable input and output of solution, thereby improving the preparation effect of nanomedicine.

[0068] Specifically, the liquid circuit control unit 2 includes: a liquid circuit integration box 21 and a first one-way valve 23.

[0069] The liquid circuit integrated box 21 has two first connection structures 211 and two second connection structures 212.

[0070] The two first connection structures 211 are respectively connected to the liquid inlet pipe 1 and the delivery pipe 5, and are used as the input end and the output end of the liquid circuit control unit 2.

[0071] The two second connection structures 212 are respectively connected to the two syringes 3, and are used to cooperate with the syringes 3 to realize the flow of solution in the fluid channel 22, and to complete the intake and expulsion of solution.

[0072] Specifically, the fluid channel 22 is disposed within the liquid circuit integration box 21 and connects the two first connection structures 211 and the two second connection structures 212.

[0073] It should be noted that the first one-way valve 23 is disposed on the fluid channel 22, so that when the two syringes 3 are running alternately in opposite directions, the input and output of liquid in the fluid channel 22 do not interfere with each other.

[0074] In order to ensure that the input and output of liquid in the fluid channel 22 do not interfere with each other when the two syringes 3 run alternately in opposite directions, the structure of the fluid channel 22 is further defined here.

[0075] Specifically, the fluid channel 22 includes two first flow channels 221, two second flow channels 222, and two sets of connecting flow channels 223.

[0076] The two first flow channels 221 are respectively connected to the two first connection structures 211 to complete the output of the solution.

[0077] The two second flow channels 222 are respectively connected to the two second connection structures 212 to complete the input of the solution.

[0078] One of the two second flow channels 222 is interconnected with the two first flow channels 221 via a connecting flow channel 223 on the same side; the other of the two second flow channels 222 is also interconnected with the two first flow channels 221 via a connecting flow channel 223 on the same side. That is, by setting up the connecting flow channel 223, the second flow channels 222 and the first flow channels 221 are connected together to form an input and output path for the solution. This allows the two syringes 3 to conveniently transfer the solution to the first flow channel 221 under different operating conditions, further improving the continuity and stability of solution delivery. It also helps to balance the pressure within the flow channels, preventing pressure fluctuations from adversely affecting the nanomedicine preparation process.

[0079] It should be noted that each of the connected flow channels 223 has two first check valves 23 arranged in opposite directions.

[0080] This allows the two first one-way valves 23 to control the flow direction of the solution separately under different working conditions of the syringe 3.

[0081] For example, when a syringe 3 performs an aspiration action (such as...) Figure 3 As shown), one of the first one-way valves 23 is turned on, allowing the solution to flow from the first flow channel 221 into the second flow channel 222 corresponding to the syringe 3, thus completing the input of the solution. Meanwhile, the first one-way valve 23, which is set in the opposite direction to the first one-way valve 23, cuts off the output path.

[0082] When the syringe 3 performs a pushing action (such as...) Figure 4 As shown), another first check valve 23 is opened, allowing the solution to flow from the second flow channel 222 into the first flow channel 221 and out through the first connection structure 211, thus completing the output of the solution. The first check valve 23, which is opposite to and set in the opposite direction to the first check valve 23, cuts off the input path to prevent the solution from flowing back.

[0083] In other embodiments, to prevent the solution from coming into contact with the external environment and becoming contaminated, the first connecting structure 211 and the second connecting structure 212 are further defined to improve the sealing effect and thus ensure the preparation effect.

[0084] Specifically, the end of the first connecting structure 211 has a sterile connector, and the inlet pipe 1 and the first connecting structure 211, as well as the delivery pipe 5 and the first connecting structure 211, are detachably and sealed through the sterile connector.

[0085] In this embodiment, the syringe 3 is slidably inserted into the second connecting structure 212.

[0086] Furthermore, the outer wall of the second connecting structure 212 has an annular elastic protrusion 9, and when the barrel of the syringe 3 is inserted into the second connecting structure 212, the annular elastic protrusion 9 can abut against and fit against the inner wall of the syringe 3 to form a sealing structure.

[0087] like Figure 5 As shown, in other embodiments, the outer wall of the syringe 3 is provided with a telescopic sleeve 10. When the syringe 3 performs a suction or pushing action, the plunger of the syringe 3 is always located in the sealed cavity formed between the syringe 3 barrel and the telescopic sleeve 10. That is, by providing the telescopic sleeve 10, the sealing performance of the syringe 3 is improved, thereby further ensuring the preparation effect.

[0088] In this embodiment, the telescopic sleeve 10 includes an integrally formed hollow sleeve 101 and a sealing sleeve 102.

[0089] One end of the hollow sleeve 101 has a flat cut surface, which is fixedly connected to the skirt end face of the syringe 3, such as by bonding.

[0090] The sealing sleeve 102 is disposed at the other end of the hollow sleeve 101, and the sealing sleeve 102 is sleeved and fixed to the outer wall of the bottom end of the syringe rod of the syringe 3.

[0091] In one example, the hollow sleeve 101 is configured as a bellows.

[0092] Furthermore, each of the delivery pipes 5 is equipped with a second one-way valve 51, which is used to prevent cross-contamination of solutions. That is, by setting the second one-way valve 51, the solution in multiple delivery pipes 5 is prevented from crossing due to flow rate differences (such as when the solution in one delivery pipe 5 flows faster than the solution in another delivery pipe 5).

[0093] It should also be noted that the inlet pipe 1, liquid circuit control unit 2, syringe 3, microfluidic chip 4, delivery pipe 5, sample recovery pipe 6, dilution phase input pipe 7, and waste recovery pipe 8 of the pipeline connection structure are connected to form a disposable pipeline consumable. Through integrated modular structure design and set as a disposable pipeline consumable structure, it is convenient to use quickly.

[0094] Obviously, those skilled in the art can make various modifications and variations to this utility model without departing from its spirit and scope. Therefore, if these modifications and variations fall within the scope of the claims of this utility model and their equivalents, this utility model also intends to include these modifications and variations.

Claims

1. A tubular connection structure for nanomedicine preparation, characterized in that, include: At least two inlet pipes (1) are used to transport the lipid phase solution and the aqueous phase solution, respectively; The microfluidic chip (4) has an aqueous solution inlet, a lipid solution inlet, a mixing channel, and a solution outlet; The liquid circuit control unit (2) is provided in correspondence with the liquid inlet pipe (1) for conveying the lipid phase solution and the aqueous phase solution. Each liquid circuit control unit (2) is provided with a fluid channel (22). The input end of the fluid channel (22) is connected to the corresponding liquid inlet pipe (1). The output end of the fluid channel (22) is connected to the aqueous phase solution inlet or lipid phase solution inlet of the microfluidic chip (4) through a delivery pipe (5). The fluid drive unit is configured one-to-one with the liquid circuit control unit (2). Each fluid drive unit includes two syringes (3) with opposite directions of movement. The injection ends of the two syringes (3) are respectively connected to the fluid channel (22) of the liquid circuit control unit (2) to continuously draw the liquid in the inlet tube (1) into the fluid channel (22) of the liquid circuit control unit (2) and push the liquid in the fluid channel (22) into the microfluidic chip (4). The solution outlet of the microfluidic chip (4) is connected to a sample recovery tube (6); The sample recovery tube (6) is connected in sequence to a dilution phase input tube (7) and a waste recovery tube (8) from the liquid output direction; both the waste recovery tube (8) and the sample recovery tube (6) are equipped with tube clamps (11) for controlling the discharge of the mixed solution containing the dilution phase liquid.

2. The tubing connection structure for nanomedicine preparation as described in claim 1, characterized in that, The liquid circuit control unit (2) includes: a liquid circuit integration box (21) and a first one-way valve (23); The liquid circuit integrated box (21) has two first connection structures (211) and two second connection structures (212); The two first connection structures (211) are respectively connected to the liquid inlet pipe (1) and the delivery pipe (5) and are used as the input end and output end of the liquid circuit control unit (2); The two second connection structures (212) are respectively connected to the two syringes (3); The fluid channel (22) is disposed in the liquid circuit integration box (21) and connects the two first connection structures (211) and the two second connection structures (212); The first one-way valve (23) is disposed on the fluid channel (22) so that the input and output of liquid in the fluid channel (22) do not interfere with each other when the two syringes (3) are running alternately in opposite directions.

3. The tubing connection structure for nanomedicine preparation as described in claim 2, characterized in that, The fluid channel (22) includes two first flow channels (221), two second flow channels (222), and two sets of connecting flow channels (223); The two first flow channels (221) are respectively connected to the two first connecting structures (211); The two second flow channels (222) are respectively connected to the two second connecting structures (212); One of the two second flow channels (222) is connected to the two first flow channels (221) through a connecting flow channel (223) on the same side; the other of the two second flow channels (222) is also connected to the two first flow channels (221) through a connecting flow channel (223) on the same side; two first check valves (23) arranged in opposite directions are arranged on each set of connecting flow channels (223).

4. The tubing connection structure for nanomedicine preparation as described in claim 2, characterized in that, The end of the first connecting structure (211) has a sterile connector, and the inlet tube (1) and the first connecting structure (211) and the delivery tube (5) and the first connecting structure (211) are detachably sealed through the sterile connector.

5. The tubing connection structure for nanomedicine preparation as described in claim 2, characterized in that, The syringe (3) barrel is slidably inserted into the second connecting structure (212); The outer wall of the second connecting structure (212) has an annular elastic protrusion (9), and when the barrel of the syringe (3) is inserted into the second connecting structure (212), the annular elastic protrusion (9) can abut against and fit against the inner wall of the syringe (3) to form a sealing structure.

6. The tubing connection structure for nanomedicine preparation as described in claim 1, characterized in that, The syringe (3) has a telescopic sleeve (10) on its outer wall. When the syringe (3) performs a suction or pushing action, the plunger of the syringe (3) is always located in the sealed cavity formed between the syringe (3) barrel and the telescopic sleeve (10).

7. The tubing connection structure for nanomedicine preparation as described in claim 6, characterized in that, The telescopic sleeve (10) includes a hollow sleeve (101) and a sealing sleeve (102) that are integrally formed; One end of the hollow sleeve (101) has a flat cut surface, which is fixedly connected to the skirt end face of the syringe (3); The sealing sleeve (102) is disposed at the other end of the hollow sleeve (101), and the sealing sleeve (102) is sleeved and fixed to the outer wall of the bottom end of the syringe (3).

8. The tubing connection structure for nanomedicine preparation as described in claim 7, characterized in that, The hollow sleeve (101) is configured as a corrugated pipe.

9. The tubing connection structure for nanomedicine preparation as described in any one of claims 1-8, characterized in that, Each of the conveying pipes (5) is equipped with a second check valve (51), which is used to prevent cross-contamination of liquid.

10. The tubing connection structure for nanomedicine preparation as described in any one of claims 1-8, characterized in that, The inlet pipe (1), liquid circuit control unit (2), syringe (3), microfluidic chip (4), delivery pipe (5), sample recovery pipe (6), dilution phase input pipe (7) and waste recovery pipe (8) of the pipeline connection structure are connected to form a disposable pipeline consumable.

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