A constant temperature liquid supply system for a drug detection dissolution tester
By introducing components such as a constant-temperature storage tank, an ultrasonic defoamer, and a peristaltic pump into the dissolution apparatus to construct a closed-loop circulation system, the problems of long heating time and unstable temperature in the dissolution apparatus are solved, and efficient and accurate results for drug testing are achieved.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- SHANGHAI SINE WANXIANG PHARMA
- Filing Date
- 2025-06-17
- Publication Date
- 2026-06-09
AI Technical Summary
Existing dissolution apparatuses suffer from long heating times for the dissolution medium and unstable replenishment temperatures during drug testing, leading to large errors in test results. Furthermore, manual operation is inefficient.
A closed-loop circulation system is constructed using a constant temperature storage tank, an ultrasonic defoamer, a peristaltic pump, and a three-way solenoid valve to achieve constant temperature control and automatic replenishment of the leaching medium. The ultrasonic defoamer removes bubbles, the peristaltic pump controls the medium flow rate, and the three-way solenoid valve switches the medium flow direction.
It greatly shortens the testing time, improves testing efficiency and result accuracy, and avoids temperature fluctuations and human error.
Smart Images
Figure CN224341516U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to a dissolution apparatus, and more particularly to a constant temperature liquid supply system for a drug detection dissolution apparatus. Background Technology
[0002] In the field of pharmaceutical quality control and R&D, dissolution testing is one of the key in vitro testing methods for evaluating the intrinsic quality of oral solid dosage forms (such as tablets and capsules). As the core equipment for performing this test, the operating status of the dissolution apparatus, especially the accuracy and stability of the temperature control of the dissolution medium, directly affects the accuracy, reproducibility, and reliability of the test results, thus influencing the assessment of batch-to-batch quality consistency, process stability, and bioequivalence of the drug.
[0003] Currently, in the testing of solid dosage form intermediates and finished products in factories, the dissolution medium used in dissolution apparatus requires degassing for 10 to 30 minutes and heating to 37°C in a water bath for 60 to 90 minutes. This inevitably leads to long preparation times, low work efficiency, and potentially untimely testing. During use, multiple samples are needed to create dissolution profiles, and an equivalent amount of the same dissolution medium must be added after each sample. Adding dissolution medium at different temperatures can affect test results, and the process is inefficient and prone to errors and omissions. Utility Model Content
[0004] The technical problem to be solved by this utility model is to provide a constant temperature liquid supply system for a drug dissolution tester, which can automatically add dissolution medium quantitatively while simultaneously removing bubbles and heating via ultrasound, in order to address the deficiencies of the existing technology.
[0005] To solve the above-mentioned technical problems, this utility model adopts the following technical solution:
[0006] A constant temperature liquid supply system for a drug dissolution apparatus includes a constant temperature storage tank, an ultrasonic defoamer, a peristaltic pump, and a three-way solenoid valve. The constant temperature storage tank is connected to two ports of the three-way solenoid valve through an inlet pipe and a return pipe, respectively. The third port of the three-way solenoid valve is connected to the dissolution apparatus. The ultrasonic defoamer and the peristaltic pump are installed on the inlet pipe.
[0007] Preferably, the constant temperature storage tank is equipped with an electric heater, a temperature sensor, and a level gauge.
[0008] Preferably, the lower end of the constant temperature storage tank is connected to the liquid inlet pipe, and the middle and upper ends are connected to the return pipe.
[0009] Preferably, the constant temperature storage tank is provided with a liquid filling port and a pressure reducing valve at the top, and a liquid drain port at the bottom.
[0010] Preferably, the ultrasonic defoamer is located upstream of the inlet pipe, and the peristaltic pump is located downstream of the inlet pipe.
[0011] Preferably, the end of the inlet pipe is provided with several parallel inlet branch pipes, and the end of the return pipe is provided with several return branch pipes corresponding to the inlet branch pipes. Each set of inlet branch pipes and return branch pipes is connected to two ports of the corresponding three-way solenoid valve.
[0012] More preferably, there are several three-way solenoid valves, and each third port is connected to a corresponding dissolution flask on the dissolution apparatus system.
[0013] Preferably, the constant temperature storage tank is a single-hole constant temperature water bath, model DZKW-C from Nanbei Instruments; the ultrasonic defoamer is an experimental-grade solution ultrasonic degassing and defoaming instrument, model FS-UE2010GL from Hangzhou Fansuneng.
[0014] Preferably, the inlet pipe and the return pipe are made of perfluoroalkoxy resin, polyvinylidene fluoride, or polytetrafluoroethylene.
[0015] Preferably, the constant temperature storage tank, inlet pipe, reflux pipe, ultrasonic defoamer, peristaltic pump and three-way solenoid valve are integrated and installed inside the dissolution apparatus housing.
[0016] The present invention adopts the above technical solution and has the following technical effects compared with the prior art:
[0017] The constant-temperature liquid supply system for a drug dissolution apparatus provided by this utility model improves upon existing drug dissolution apparatuses by adding a constant-temperature storage tank, an ultrasonic defoamer, a peristaltic pump, and several three-way solenoid valves. The constant-temperature storage tank is connected in parallel to two ports of multiple three-way solenoid valves via inlet and reflux pipes. The third port of each three-way solenoid valve is connected to each dissolution flask inside the dissolution apparatus. The ultrasonic defoamer and peristaltic pump are installed on the inlet pipe. This constant-temperature liquid supply system can automatically add dissolution medium quantitatively as needed, while simultaneously removing air bubbles from the dissolution medium ultrasonically and automatically heating the dissolution medium, greatly shortening the testing time, improving testing efficiency, and ensuring the accuracy of test results. Attached Figure Description
[0018] Figure 1 This is a schematic diagram of the overall framework structure of a constant temperature liquid supply system for a drug dissolution tester according to the present invention;
[0019] Figure 2 This is a schematic diagram of the structure of a constant temperature storage tank in a constant temperature liquid supply system of a drug dissolution tester according to the present invention.
[0020] The accompanying figures are labeled as follows:
[0021] 100-Constant temperature storage tank; 101-Electric heater; 102-Temperature sensor; 103-Level gauge; 104-Inlet port; 105-Pressure reducing valve; 106-Drain port; 110-Inlet pipe; 111-Inlet branch pipe; 120-Return pipe; 121-Return branch pipe; 200-Ultrasonic defoamer; 300-Peristaltic pump; 400-Three-way solenoid valve; 500-Dissolution apparatus body. Detailed Implementation
[0022] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments.
[0023] Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this utility model.
[0024] In one embodiment, such as Figure 1 As shown, in order to solve the technical problems of long heating time of dissolution medium, unstable replenishment temperature leading to large error in test results and low efficiency of manual operation in the existing dissolution tester, a constant temperature liquid supply system for drug testing dissolution tester is provided. The system mainly includes a constant temperature storage tank 100, an ultrasonic defoamer 200, a peristaltic pump 300 and a three-way solenoid valve 400. By constructing a closed-loop circulation system through these components, the constant temperature control and automatic replenishment of dissolution medium can be realized.
[0025] Specifically, the constant temperature storage tank 100 serves as the core temperature control unit. It is connected to two ports of the three-way solenoid valve 400 through the liquid inlet pipe 110 and the return pipe 120, respectively. The third port of the three-way solenoid valve 400 is connected to the dissolution apparatus 500 to form a dissolution medium circulation loop between the dissolution apparatus body 500 and the constant temperature storage tank 100, ensuring the continuity of heat exchange between the dissolution medium and the two.
[0026] The ultrasonic defoamer 200 is installed upstream of the inlet pipe 110 to degas the medium, eliminating the impact of air bubbles in the dissolution medium on detection accuracy. The peristaltic pump 300 is installed downstream of the inlet pipe 110 to precisely control the medium flow rate, and works with the three-way solenoid 400 to switch the flow direction of the dissolution medium between the constant temperature storage tank 100 and the dissolution apparatus 500.
[0027] The three-way solenoid valve 400's three-port connection structure not only meets the media delivery requirements but also enables automatic return of unused media by switching valve positions, maintaining system temperature balance. In this constant-temperature liquid supply system, the components are connected via specific pipelines to form an integrated system. The inlet pipe 110 simultaneously performs defoaming and pumping functions, while the return pipe 120 handles media recovery, together constituting a complete constant-temperature liquid supply system.
[0028] In one embodiment, such as Figure 2 As shown, according to practical application needs, an electric heater 101, a temperature sensor 102, and a level gauge 103 are installed on the constant temperature storage tank 100. The electric heater 101, temperature sensor 102, and level gauge 103 all use commercially available electrical components. Their working principles, structures, and installation methods are known technologies and will not be elaborated upon here. Through the coordinated operation of these three components, the drawbacks of time-consuming traditional manual heating are solved, the technical obstacle of large temperature fluctuations in open storage tanks is overcome, and intelligent monitoring of the liquid storage status is achieved.
[0029] In one embodiment, such as Figure 1 and Figure 2 As shown, to further optimize the circulation path of the dissolution medium, the lower end of the constant temperature storage tank 100 is connected to the inlet pipe 110, ensuring that the fully heated dissolution medium is drawn from the bottom of the constant temperature storage tank 100. Simultaneously, the upper middle end of the constant temperature storage tank 100 is connected to the return pipe 120, allowing the circulated dissolution medium to return at a higher level. This promotes temperature exchange between the return liquid and the original medium in the constant temperature storage tank 100, and also reduces the incorporation of air bubbles due to the liquid level difference.
[0030] In one embodiment, such as Figure 2 As shown, to achieve efficient management and system safety control of the leaching medium in the constant temperature storage tank 100, a liquid inlet 104 and a pressure reducing valve 105 are provided at the top of the constant temperature storage tank 100, and a liquid outlet 106 is provided at the bottom. Manual valves are installed at both the liquid inlet 104 and the liquid outlet 106.
[0031] Specifically, the design of the liquid inlet 104 at the top of the thermostatic storage tank 100 facilitates the direct replenishment of the dissolving medium into the tank, avoiding heat loss caused by traditional open-type liquid addition methods and reducing the risk of external contaminants entering the system. The pressure reducing valve 105 at the top of the thermostatic storage tank 100 actively regulates the internal pressure, preventing pressure anomalies caused by liquid circulation or temperature changes, ensuring the stability of medium flow and equipment safety. The drain port at the bottom of the thermostatic storage tank 100 is positioned low, utilizing gravity to completely empty the liquid from the tank. This facilitates thorough removal of residual medium during system maintenance and avoids cross-contamination or temperature control deviations caused by liquid stagnation.
[0032] In one embodiment, such as Figure 1As shown, the ultrasonic defoamer 200 is positioned upstream of the inlet pipe 110 to eliminate air bubbles in the dissolving medium. The peristaltic pump 300 is positioned downstream of the inlet pipe 110 to maintain the circulation power of the entire liquid supply system through pump pressure.
[0033] In one embodiment, such as Figure 1 As shown, to address the issue that existing dissolution apparatuses cannot simultaneously provide independent circulating liquid supply to multiple dissolution flasks, avoid the mixing of media at different temperatures during replenishment leading to testing errors, and improve the efficiency of multi-channel liquid supply, several parallel inlet branch pipes 111 are provided at the end of the inlet pipe 110, and several return branch pipes 121 corresponding to the inlet branch pipes 111 are provided at the end of the return pipe 120. Each set of inlet branch pipes 111 and return branch pipes 121 is respectively connected to two ports of the corresponding three-way solenoid valve 400.
[0034] Specifically, by setting multiple parallel inlet branch pipes 111 at the end of the inlet pipe 110, and setting a corresponding number of return branch pipes 121 at the end of the return pipe 120, each group of branch pipes forms a closed loop with an independent three-way solenoid valve 400. This structural design allows each dissolution flask to have an independent supply and return channel, so that multiple dissolution flasks can be supplied with liquid simultaneously without interference.
[0035] The parallel layout of the inlet branch pipes 111 ensures balanced flow in each branch, while the corresponding return branch pipes 121 ensure consistent liquid temperature in each dissolution flask during circulation. The three-way solenoid valve 400, with its three-port connection, allows for individual control of each circulation branch while maintaining directional flow of the dissolution medium between the constant-temperature storage tank 100 and the dissolution flasks, thus preventing cross-contamination between different batches or at different temperatures of the dissolution medium.
[0036] In one embodiment, such as Figure 1 As shown, corresponding to the multiple parallel inlet branch pipes 111 and return branch pipes 121, there are several three-way solenoid valves 400, each with its third interface connected to a dissolution flask on the dissolution apparatus system 500, forming a point-to-point control structure.
[0037] This structural design allows the media supply path and return path of each dissolution flask to form a closed loop. When the peristaltic pump 300 drives the media flow, each three-way solenoid valve 400 can independently switch between liquid inlet and return states. This not only avoids temperature fluctuations and uneven flow distribution caused by multiple dissolution flasks sharing pipelines, but also realizes the differentiated liquid replenishment needs of different dissolution flasks.
[0038] In one embodiment, the constant temperature storage tank 100 is a single-hole constant temperature water bath, model DZKW-C from Nanbei Instruments, equipped with an electric heater 101, a temperature sensor 102, and a level gauge 103. It has a liquid inlet 104 at the top and a liquid outlet 106 at the bottom, and a pressure reducing valve 105 on the sealing cover at the top of the constant temperature water bath. The ultrasonic defoamer 200 is an experimental-grade ultrasonic degassing and defoaming instrument, model FS-UE2010GL from Hangzhou Fansuneng, specifically a benchtop degassing and defoaming instrument with an independent inlet and outlet liquid tank. The inlet and outlet of the defoaming tank are connected to the corresponding inlet pipe 110.
[0039] In one embodiment, the inlet pipe 110 and the return pipe 120 are made of perfluoroalkoxy resin PFA pipe, polyvinylidene fluoride PVDF pipe or polytetrafluoroethylene PTFE pipe. By utilizing the chemical inertness and corrosion resistance of these materials, the chemical reaction or corrosion of the pipeline with the leaching medium during transportation is effectively avoided.
[0040] Specifically, perfluoroalkoxy resin (PFA) pipes possess excellent high-temperature resistance and impermeability, capable of withstanding the leaching medium temperature after heating in a constant-temperature storage tank; polyvinylidene fluoride (PVDF) pipes exhibit outstanding resistance to acids, alkalis, and organic solvents, making them suitable for leaching media of various properties; and polytetrafluoroethylene (PTFE) pipes, with their extremely low surface adhesion and superior corrosion resistance, can prevent media residue and pipe blockage. The choice depends on the type of leaching medium and the specific application requirements.
[0041] In one embodiment, to avoid the problems of large equipment size, inconvenient operation and maintenance, and susceptibility of external connection pipelines to ambient temperature interference caused by the dispersed arrangement of the dissolution apparatus's liquid supply system, the constant temperature storage tank 100, inlet pipe 110, reflux pipe 120, ultrasonic defoamer 200, peristaltic pump 300, and three-way solenoid valve 400 are integrated into the dissolution apparatus 500 housing, forming a compact integrated structure. This integrated installation method optimizes the equipment's footprint, eliminates the need for operators to cross equipment during sampling, liquid replenishment, and other operations, reduces the risk of human error, and improves the stability and reliability of the system operation.
[0042] In addition, it is worth noting that the electric heater 101, temperature sensor 102, liquid level gauge 103, ultrasonic defoamer 200, peristaltic pump 300 and three-way solenoid valve 400 installed on the constant temperature storage tank 100 are all connected to the PLC controller of the original dissolution apparatus 500, and are automatically controlled by the PLC controller.
[0043] Combination Figure 1 and Figure 2The working principle of the constant temperature liquid supply system of this drug dissolution apparatus is as follows: During use, the dissolution medium is pre-filled into the constant temperature storage tank 100. The peristaltic pump 300 is activated, and the dissolution medium, after being defoamed by the ultrasonic defoamer 200, is supplied to the corresponding dissolution flask in the dissolution apparatus 500 via the corresponding three-way solenoid valve 100. When not in use, the three-way solenoid valve 400 controls the return flow through the reflux pipe 120 to the constant temperature storage tank 100, where it is reheated to maintain a constant temperature. Furthermore, this constant temperature liquid supply system can automatically add dissolution medium quantitatively as needed, while simultaneously using ultrasound to remove air bubbles and automatically heating the dissolution medium, significantly shortening the testing time, improving testing efficiency, and ensuring the accuracy of the test results.
[0044] Finally, the following points should be noted: First, in the description of this application, it should be noted that, unless otherwise specified and limited, the terms "installation", "connection", and "linkage" should be interpreted broadly, and can be mechanical or electrical connections, or internal connections between two components, or direct connections. "Up", "down", "left", "right", etc. are only used to indicate relative positional relationships. When the absolute position of the described object changes, the relative positional relationship may change.
[0045] Secondly, the accompanying drawings of the embodiments disclosed in this utility model only involve the structures involved in the embodiments disclosed in this utility model. Other structures can refer to the general design. In the absence of conflict, the same embodiment and different embodiments of this utility model can be combined with each other.
[0046] Finally, the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.
Claims
1. A constant temperature liquid supply system for a drug dissolution tester, characterized in that, The device includes a constant temperature storage tank (100), an ultrasonic defoamer (200), a peristaltic pump (300), and a three-way solenoid valve (400). The constant temperature storage tank (100) is connected to two ports of the three-way solenoid valve (400) through an inlet pipe (110) and a return pipe (120). The third port of the three-way solenoid valve (400) is connected to a dissolution apparatus (500). The ultrasonic defoamer (200) and the peristaltic pump (300) are installed on the inlet pipe (110).
2. The constant temperature liquid supply system for the drug dissolution apparatus according to claim 1, characterized in that, The constant temperature storage tank (100) is equipped with an electric heater (101), a temperature sensor (102), and a level gauge (103).
3. The constant temperature liquid supply system for the drug dissolution apparatus according to claim 1, characterized in that, The lower end of the constant temperature storage tank (100) is connected to the liquid inlet pipe (110), and the middle and upper ends are connected to the return pipe (120).
4. The constant temperature liquid supply system for the drug dissolution apparatus according to claim 1, characterized in that, The constant temperature storage tank (100) is provided with a liquid filling port (104) and a pressure reducing valve (105) at the top, and a liquid drain port (106) at the bottom.
5. The constant temperature liquid supply system for the drug dissolution apparatus according to claim 1, characterized in that, The ultrasonic defoamer (200) is located upstream of the liquid inlet pipe (110), and the peristaltic pump (300) is located downstream of the liquid inlet pipe (110).
6. The constant temperature liquid supply system for the drug dissolution apparatus according to claim 1, characterized in that, The inlet pipe (110) is provided with several parallel inlet branch pipes (111) at its tail end, and the return pipe (120) is provided with several return branch pipes (121) corresponding to the inlet branch pipes (111) at its tail end. Each set of inlet branch pipes (111) and return branch pipes (121) is respectively connected to two interfaces of the corresponding three-way solenoid valve (400).
7. The constant temperature liquid supply system for the drug dissolution apparatus according to claim 6, characterized in that, There are several three-way solenoid valves (400), and each third port is connected to a corresponding dissolution flask on the dissolution apparatus system (500).
8. The constant temperature liquid supply system for the drug dissolution apparatus according to claim 1, characterized in that, The constant temperature storage tank (100) is a single-hole constant temperature water bath, model DZKW-C of Nanbei Instruments; the ultrasonic defoamer (200) is an experimental-grade ultrasonic degassing and defoaming instrument, model FS-UE2010GL of Hangzhou Fansuneng.
9. The constant temperature liquid supply system for the drug dissolution apparatus according to claim 1, characterized in that, The inlet pipe (110) and the return pipe (120) are made of perfluoroalkoxy resin (PFA), polyvinylidene fluoride (PVDF) or polytetrafluoroethylene (PTFE).
10. The constant temperature liquid supply system for the drug dissolution apparatus according to claim 1, characterized in that, The constant temperature storage tank (100), inlet pipe (110), reflux pipe (120), ultrasonic defoamer (200), peristaltic pump (300) and three-way solenoid valve (400) are integrated and installed in the housing of the dissolution apparatus (500).