A soluble silk fibroin pellet quick-freezing, separating and collecting device

By using liquid nitrogen quick-freezing and gravity dripping molding, combined with liquid nitrogen recycling, the problems of long freeze-drying time, poor resolubility and high cost in existing technologies have been solved, achieving efficient preparation of soluble silk fibroin microspheres and improving production efficiency and resolubility.

CN224405066UActive Publication Date: 2026-06-26WESTLAKE UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
WESTLAKE UNIV
Filing Date
2025-04-23
Publication Date
2026-06-26

AI Technical Summary

Technical Problem

Existing technologies for preparing soluble silk fibroin involve long freeze-drying times, poor resolubility, easy damage to protein structure by shear force, and the inability to recycle liquid nitrogen, resulting in low production efficiency and high costs.

Method used

An integrated device is adopted, which consists of a cryogenic treatment tank and an external insulation tank. It uses liquid nitrogen to freeze silk fibroin solution to form microspheres, avoiding high shear force, and achieving high specific surface area and controllable particle size of microspheres, while recycling liquid nitrogen.

Benefits of technology

It shortens freeze-drying time to less than 24 hours, increases production efficiency by nearly 2 times, improves resolubility, reduces costs, protects biological activity, and expands application scenarios.

✦ Generated by Eureka AI based on patent content.

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Abstract

The application relates to a soluble silk fibroin pellet quick-freezing, separating and collecting device. The device comprises a low-temperature treatment tank, an external heat preservation tank, a feeding assembly, a separating assembly and an electric control system. The low-temperature treatment tank is nested in the external heat preservation tank and is adiabatic; the feeding assembly is arranged between a top cover plate and an adiabatic plate and comprises a material feeding pipe, a liquid nitrogen feeding pipe and a recovery pipe; a liquid drop pipe is arranged in the material pipe and is provided with a heating device arranged inside the liquid drop pipe to prevent freezing; liquid drops fall through the adiabatic plate into liquid nitrogen to be quickly frozen into small balls. The parameters of a stirring paddle can be adjusted to control the particle diameter, and a peristaltic pump and the specification of the drop pipe are used to control the size. The quick-frozen mixture flows into a separating tank through a low-temperature electromagnetic valve, small balls are intercepted by a screen, and liquid nitrogen is recycled. The electric control system is used for regulating and controlling stirring, the electromagnetic valve and heating power. The device can ensure resolubility through low shear quick freezing, the quick-frozen mixture can be freeze-dried in less than 24 hours due to the high specific surface area of the small balls, the cost is reduced through liquid nitrogen circulation, and the flux and particle diameter can be controlled through multi-parameter adjustment, so that the device is suitable for the preparation of silk fibroin and composite materials.
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