Freeze centrifuge for separating and purifying pharmaceuticals

Abstract

The utility model relates to centrifuge technical field discloses the freeze centrifuge of medicine separation and purification, including centrifuge body, centrifuge body one side fixedly connected with control panel, centrifuge body inside is provided with centrifugal head, centrifugal head inside fixedly connected with support plate, support plate top is provided with a plurality of support components, support component includes connecting frame, connecting frame bottom fixedly connected in support plate top, centrifuge body side wall is provided with buffer assembly. In the utility model, the centrifugal tube is put into the connecting frame, the rubber plate is extruded, the rubber plate is elastically deformed, the spring one is deformed further by the deformation of the rubber plate, the effect of the elastic position support of the centrifugal tube is realized, the problem that the centrifugal tube is easily broken and the sample is easily leaked due to the collision and friction when rotating at high speed is solved, and the safety of the medicine separation and purification experiment is improved.

Description

Technical Field

[0001] This utility model relates to the field of centrifuge technology, and in particular to a refrigerated centrifuge for the separation and purification of pharmaceuticals. Background Technology

[0002] Refrigerated centrifuges for drug separation and purification play an irreplaceable role in industries such as biopharmaceuticals and chemical pharmaceuticals. They maintain a low-temperature environment through a refrigeration system to prevent drug components from denaturing or becoming inactive due to high temperatures during centrifugation. At the same time, they use centrifugal force to separate drug particles of different densities and sizes. They are widely used in the separation and purification of drugs such as proteins, nucleic acids, and traditional Chinese medicine extracts, and are one of the core pieces of equipment to ensure drug quality and activity.

[0003] The mechanical structure of existing refrigerated centrifuges mainly includes a centrifuge rotor, a refrigeration system, a drive system, and a control system. The centrifuge rotor is used to hold centrifuge tubes. Through angled or horizontal designs, it can be used with centrifuge tubes of different sizes to load samples. The refrigeration system uses a compressor for refrigeration to precisely control the temperature of the centrifuge chamber. The drive system uses a variable frequency motor to provide power to achieve high-speed rotation of the rotor. The control system is responsible for setting and monitoring parameters such as rotation speed, time, and temperature. Its technical principle is based on the difference in the sedimentation velocity of substances in the centrifugal force field, combined with low temperature protection, to achieve the separation and purification of drug samples.

[0004] However, during operation, existing refrigerated centrifuges experience frequent collisions and friction between the centrifuge tubes and the rotor mounting holes due to high-speed rotation and vibration. These collisions and frictions can easily lead to centrifuge tube breakage, sample leakage, and experimental failure. Furthermore, the fragments generated by broken centrifuge tubes can damage the internal structure of the centrifuge, posing certain safety hazards and significantly affecting the safety and reliability of drug separation and purification experiments. Therefore, a refrigerated centrifuge for drug separation and purification is proposed to solve the above problems. Utility Model Content

[0005] To overcome the above shortcomings, this utility model provides a refrigerated centrifuge for drug separation and purification, aiming to improve the problems of frequent collisions and friction between centrifuge tubes and rotor mounting holes caused by high-speed rotation and self-vibration during operation of existing refrigerated centrifuges, which in turn leads to centrifuge tube breakage, sample leakage, and internal damage to the centrifuge, affecting the safety and reliability of experiments.

[0006] To achieve the above objectives, the present invention adopts the following technical solution:

[0007] A refrigerated centrifuge for separating and purifying pharmaceuticals includes a centrifuge body, a control panel fixedly connected to one side of the centrifuge body, a centrifuge rotor inside the centrifuge body, a support plate fixedly connected inside the centrifuge rotor, and multiple support components on the top of the support plate.

[0008] The support assembly includes a connecting frame, the bottom of which is fixedly connected to the top of the support plate. A connecting shaft is fixedly connected to the inner wall of the connecting frame, and a sliding shaft is slidably connected inside the connecting shaft. A rubber plate is fixedly connected to one end of the sliding shaft, and multiple anti-slip grooves are formed inside the rubber plate. A spring is provided on the outer wall of the connecting shaft, one end of which is fixedly connected to the side wall of the connecting shaft, and the other end is fixedly connected to the side wall of the sliding shaft. A buffer assembly is provided on the side wall of the centrifuge body.

[0009] As a further description of the above technical solution:

[0010] The buffer assembly includes a connecting plate and bolts. One side of the connecting plate is slidably connected to the outer wall of the centrifuge body, and the bolts are threadedly connected inside the connecting plate.

[0011] As a further description of the above technical solution:

[0012] A support column is fixedly connected to one side of the connecting plate, and an extrusion shaft is slidably connected to the outer wall of the support column.

[0013] As a further description of the above technical solution:

[0014] The outer wall of the support column is provided with a second spring. One end of the second spring is fixedly connected to the side wall of the connecting plate, and the other end is fixedly connected to one side of the extrusion shaft.

[0015] As a further description of the above technical solution:

[0016] A connecting column is fixedly connected to the outer wall of the extrusion shaft, and a limit column is slidably connected to the outer wall of the connecting column.

[0017] As a further description of the above technical solution:

[0018] A support block is fixedly connected inside the limiting post, and a spring is provided on the outer wall of the connecting post.

[0019] As a further description of the above technical solution:

[0020] One end of the spring is fixedly connected to the outer wall of the extrusion shaft, and the other end is fixedly connected to the side wall of the connecting column.

[0021] This utility model has the following beneficial effects:

[0022] 1. In this utility model, by placing the centrifuge tube inside the connecting frame, the rubber plate is squeezed, causing the rubber plate to deform elastically. The deformation of the rubber plate further drives the spring to deform, thereby achieving the effect of elastic limiting support for the centrifuge tube. This solves the problem of centrifuge tubes being prone to breakage due to collision and friction during high-speed rotation and sample leakage, and improves the safety of drug separation and purification experiments.

[0023] 2. In this utility model, the support column slides inside the extrusion shaft to compress the second spring, causing elastic deformation. The connecting column slides inside the limiting column to compress the third spring, causing elastic deformation. The deformation of the second and third springs can quickly absorb and buffer the impact force, solving the problems of equipment wear, noise pollution, and unstable centrifugation caused by vibration during centrifuge operation, and improving the stability of equipment operation. Attached Figure Description

[0024] Figure 1 This is a three-dimensional schematic diagram of the refrigerated centrifuge for drug separation and purification proposed in this utility model;

[0025] Figure 2 This is a schematic diagram of the internal structure of the centrifuge rotor of the refrigerated centrifuge for drug separation and purification proposed in this utility model;

[0026] Figure 3 for Figure 2 Enlarged view of point A in the middle;

[0027] Figure 4 This is a schematic diagram of the structure of the side wall of the centrifuge body of the refrigerated centrifuge for drug separation and purification proposed in this utility model;

[0028] Figure 5 This is a schematic diagram of the cross-sectional structure of the limiting column of the refrigerated centrifuge for drug separation and purification proposed in this utility model.

[0029] Legend:

[0030] 1. Centrifuge body; 2. Control panel; 3. Centrifuge rotor; 4. Support plate; 5. Connecting frame; 6. Connecting shaft; 7. Sliding shaft; 8. Rubber plate; 9. Anti-slip groove; 10. Spring 1; 11. Connecting plate; 12. Bolt; 13. Support column; 14. Extrusion shaft; 15. Spring 2; 16. Connecting column; 17. Limiting column; 18. Support block; 19. Spring 3. Detailed Implementation

[0031] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention.

[0032] Reference Figures 1-3An embodiment of this utility model is provided: a refrigerated centrifuge for separating and purifying drugs, including a centrifuge body 1, a control panel 2 fixedly connected to one side of the centrifuge body 1, the function of the control panel 2 is to facilitate the user to quickly control and adjust the working state of the centrifuge body 1, a centrifuge rotor 3 is provided inside the centrifuge body 1, a support plate 4 is fixedly connected inside the centrifuge rotor 3, and multiple support components are provided on the top of the support plate 4, the support components are used to elastically support the centrifuge tube.

[0033] The support assembly includes a connecting frame 5, the bottom of which is fixedly connected to the top of the support plate 4. The connecting frame 5 provides a stable connection to the support assembly, ensuring its stability. A connecting shaft 6 is fixedly connected to the inner wall of the connecting frame 5, and a sliding shaft 7 is slidably connected inside the connecting shaft 6. A rubber plate 8 is fixedly connected to one end of the sliding shaft 7. The rubber plate 8 contacts the outer wall of the centrifuge tube, thereby restricting the movement of the centrifuge tube. Multiple anti-slip grooves 9 are formed inside the rubber plate 8 to increase the friction between the rubber plate 8 and the centrifuge tube. A spring 10 is provided on the outer wall of the connecting shaft 6. The spring 10 provides elastic support to the support assembly by its own elastic deformation. One end of the spring 10 is fixedly connected to the side wall of the connecting shaft 6, and the other end is fixedly connected to the side wall of the sliding shaft 7. A buffer assembly is provided on the side wall of the centrifuge body 1 to buffer the vibration force during the operation of the centrifuge body 1.

[0034] Specifically, when the centrifuge is running and the vibration and unbalanced force generated by high-speed rotation can easily cause centrifuge tubes to break and samples to be lost, the user first passes the centrifuge tubes containing the medicine through the connecting frame 5 and places them into the slots inside the support plate 4. During this process, the centrifuge tubes are subjected to compressive force, causing the rubber plate 8 to undergo elastic deformation, thereby making the rubber plate 8 fit tightly against the outer wall of the centrifuge tube. The rubber plate 8 is provided with anti-slip grooves 9 to enhance the friction with the outer wall of the centrifuge tube, thereby further improving the contact stability between the rubber plate 8 and the centrifuge tube. At the same time, the elastic deformation of the rubber plate 8 will cause the sliding shaft 7 to slide inside the connecting shaft 6. This action will then drive the spring 10 to undergo elastic deformation, providing a reverse force to the rubber plate 8, thereby pushing the rubber plate 8 to continuously compress the outer wall of the centrifuge tube, ensuring that the centrifuge tubes receive stable elastic support and limitation.

[0035] Reference Figure 4 and Figure 5The buffer assembly includes a connecting plate 11 and bolts 12. One side of the connecting plate 11 is slidably connected to the outer wall of the centrifuge body 1, and the bolts 12 are threaded into the inside of the connecting plate 11. The connecting plate 11 and bolts 12 facilitate quick installation and disassembly of the buffer assembly by the user. A support column 13 is fixedly connected to one side of the connecting plate 11. A compression shaft 14 is slidably connected to the outer wall of the support column 13. A second spring 15 is installed on the outer wall of the support column 13. The function of the second spring 15 is to absorb and buffer lateral vibrations or impacts through its own elastic deformation. One end of spring 15 is fixedly connected to the side wall of connecting plate 11, and the other end is fixedly connected to one side of extrusion shaft 14. A connecting column 16 is fixedly connected to the outer wall of extrusion shaft 14. A limit column 17 is slidably connected to the outer wall of connecting column 16. A support block 18 is fixedly connected inside the limit column 17. Spring 19 is provided on the outer wall of connecting column 16. The function of spring 19 is also to quickly absorb and buffer the longitudinal vibration or impact force of centrifuge body 1 by relying on its own elastic deformation. One end of spring 19 is fixedly connected to the outer wall of extrusion shaft 14, and the other end is fixedly connected to the side wall of connecting column 16.

[0036] Specifically, when the centrifuge body 1 moves, the resulting vibration force drives the support column 13 to slide inside the extrusion shaft 14, causing the extrusion spring 15 to undergo elastic deformation. The deformation of the spring 15 effectively absorbs and buffers the vibration force, ensuring that the vibration does not adversely affect the centrifuge body 1. In order to further reduce the impact force brought by the vibration, the connecting column 16 further extrudes the spring 19 through the sliding inside the limiting column 17. The elastic deformation of the spring 19 plays a role in absorbing the longitudinal impact force, thereby achieving a comprehensive buffering and stabilizing effect on the equipment. Through the combined action of the spring 15 and the spring 19, the stability and safety of the equipment during operation are guaranteed.

[0037] Working Principle: When using this refrigerated centrifuge for drug separation and purification, the operator first inserts the centrifuge tubes containing the drug through the connecting frame 5 into the groove inside the support plate 4. Under the squeezing force of the centrifuge tubes, the rubber plate 8 will undergo elastic deformation, thus tightly adhering to the outer wall of the centrifuge tubes. The anti-slip groove 9 increases the friction between the rubber plate 8 and the outer wall of the centrifuge tubes. Simultaneously, the elastic deformation of the rubber plate 8 further drives the sliding shaft 7 to slide inside the connecting shaft 6, thereby causing the spring 10 to undergo elastic deformation, providing a counterforce to the rubber plate 8. The rubber plate 8 is pushed to press against the outer wall of the centrifuge tube, thereby achieving the function of elastic support and limiting the centrifuge tube. When vibration occurs during the movement of the centrifuge body 1, the vibration force will drive the support column 13 to slide inside the compression shaft 14, and the compression spring 15 will deform. The deformation of the spring 15 will absorb and buffer the vibration force, ensuring that the vibration will not affect the centrifuge body 1. By sliding the connecting column 16 inside the limiting column 17, the spring 19 can be further compressed, causing the spring 19 to undergo elastic deformation, thereby achieving the effect of simultaneously buffering longitudinal and lateral impact forces.

[0038] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A refrigerated centrifuge for separating and purifying pharmaceuticals, comprising a centrifuge body (1), characterized in that: A control panel (2) is fixedly connected to one side of the centrifuge body (1), a centrifuge rotor (3) is provided inside the centrifuge body (1), a support plate (4) is fixedly connected inside the centrifuge rotor (3), and multiple support components are provided on the top of the support plate (4). The support assembly includes a connecting frame (5), the bottom of which is fixedly connected to the top of the support plate (4). A connecting shaft (6) is fixedly connected to the inner wall of the connecting frame (5). A sliding shaft (7) is slidably connected inside the connecting shaft (6). A rubber plate (8) is fixedly connected to one end of the sliding shaft (7). Multiple anti-slip grooves (9) are opened inside the rubber plate (8). A spring (10) is provided on the outer wall of the connecting shaft (6). One end of the spring (10) is fixedly connected to the side wall of the connecting shaft (6), and the other end is fixedly connected to the side wall of the sliding shaft (7). A buffer assembly is provided on the side wall of the centrifuge body (1).

2. The refrigerated centrifuge for drug separation and purification according to claim 1, characterized in that: The buffer assembly includes a connecting plate (11) and a bolt (12). The connecting plate (11) is slidably connected to the outer wall of the centrifuge body (1) on one side, and the bolt (12) is threadedly connected to the inside of the connecting plate (11).

3. The refrigerated centrifuge for drug separation and purification according to claim 2, characterized in that: A support column (13) is fixedly connected to one side of the connecting plate (11), and an extrusion shaft (14) is slidably connected to the outer wall of the support column (13).

4. The refrigerated centrifuge for drug separation and purification according to claim 3, characterized in that: The outer wall of the support column (13) is provided with a second spring (15). One end of the second spring (15) is fixedly connected to the side wall of the connecting plate (11), and the other end is fixedly connected to one side of the extrusion shaft (14).

5. The refrigerated centrifuge for drug separation and purification according to claim 4, characterized in that: The outer wall of the extrusion shaft (14) is fixedly connected to a connecting column (16), and the outer wall of the connecting column (16) is slidably connected to a limit column (17).

6. The refrigerated centrifuge for drug separation and purification according to claim 5, characterized in that: The limiting post (17) is fixedly connected to a support block (18), and the outer wall of the connecting post (16) is provided with a spring three (19).

7. The refrigerated centrifuge for drug separation and purification according to claim 6, characterized in that: One end of the spring (19) is fixedly connected to the outer wall of the extrusion shaft (14), and the other end is fixedly connected to the side wall of the connecting column (16).

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