A fully automated liquid handling platform

Abstract

The utility model belongs to the analysis pre -treatment technical field, concretely is a kind of full -automatic liquid processing platform, including the casing, the liquid preparation needle is equipped in the casing, the liquid preparation needle is installed in the drive mechanism that it is driven to carry out horizontal direction movement and carry out lifting movement, the base is equipped in the casing, the top of the base is used to place the sample holder of sample tube, the liquid preparation needle adds liquid to sample tube in the process of moving, the liquid preparation needle is connected with infusion pump module pump, the casing is also equipped with the cleaning mechanism for cleaning liquid preparation needle, the cleaning mechanism includes the cleaning pool for containing cleaning fluid, the utility model is moved on X, Y and Z axle by drive mechanism, and it is convenient for liquid preparation needle to carry out sample to sample tube on sample holder in turn, when one kind of liquid adds completion, liquid preparation needle is cleaned by cleaning pool, sample is added by this method, and the precision of sample is high, and sample efficiency is high, improve the accuracy of test data.

Description

Technical Field

[0001] This utility model relates to the field of pre-analytical processing technology, specifically a fully automated liquid processing platform. Background Technology

[0002] Currently, the following methods are used for liquid dispensing or related operations in the laboratory: 1. Using a pipette with a bulboscope, requiring hand-eye coordination to accurately add liquid; 2. Using a manual or automatic pipette for aspiration and dispensing; 3. Using a syringe for aspiration and dispensing. All these methods require manual calculation of the aspirated volume before operation, resulting in low efficiency, poor accuracy, and poor repeatability. Utility Model Content

[0003] In order to overcome the above-mentioned defects in the prior art, this utility model provides a fully automated liquid handling platform.

[0004] A fully automated liquid handling platform includes a housing, within which a dispensing needle is installed. The dispensing needle is mounted on a drive mechanism that enables it to move horizontally and vertically. A base is also located within the housing, with a sample holder on top for placing sample tubes. During movement, the dispensing needle adds liquid to the sample tubes. The dispensing needle is connected to an infusion pump module. The housing also includes a cleaning mechanism for cleaning the dispensing needle, comprising a cleaning tank for containing cleaning solution.

[0005] Furthermore, the driving mechanism includes a lifting and moving beam on which the dispensing needle is slidably mounted. The lifting and moving beam is slidably connected to a moving crossbeam, and the moving crossbeam is slidably connected to a moving longitudinal beam. Through the driving mechanism, the dispensing needle can move in the X, Y, and Z axis directions.

[0006] Furthermore, the base is provided with a positioning groove, the bottom of the sample holder is provided with a support leg, the support leg of the sample holder is inserted into the limiting groove, the front end of the sample holder is provided with a limiting block, and the base is provided with a limiting groove that cooperates with the limiting block.

[0007] Furthermore, the cleaning tank is provided with several cleaning troughs, the liquid dispensing needle is inserted into the cleaning trough for cleaning, the side wall of the cleaning tank is provided with an overflow hole communicating with the cleaning trough, and a drain hole is provided below the overflow hole on the cleaning tank, the overflow hole and the drain hole are connected to the pipeline.

[0008] Furthermore, the cleaning tank is connected to a peristaltic pump module via a pipeline, through which cleaning fluid is pumped into and drawn from the cleaning tank.

[0009] Furthermore, the infusion pump module includes several injection pumps, which are connected to a rotary valve and a corresponding syringe via a three-way valve.

[0010] Furthermore, an observation window is provided on the outer wall of the housing.

[0011] Due to the adoption of the above technical solutions, the beneficial technical effects of this utility model are as follows: In this utility model, the dispensing needle is driven by the driving mechanism to move along the horizontal X and Y axes and can also move along the vertical Z axis. During the movement, liquid is added to different sample tubes through the infusion pump module. After one liquid is added, the dispensing needle is cleaned through the cleaning tank. After cleaning, the dispensing needle is used by the infusion pump module to add sample liquid to the sample tubes in sequence. This method of adding samples has high precision and high efficiency, thus improving the accuracy of experimental data. Attached Figure Description

[0012] Figure 1 This is a schematic diagram of the structure of a fully automated liquid handling platform according to the present invention;

[0013] Figure 2 This is a schematic diagram of the internal structure of the casing in this utility model. Figure 1 ;

[0014] Figure 3 This utility model Figure 2 Top view;

[0015] Figure 4 This is a schematic diagram of the internal structure of the casing in this utility model. Figure 2 ;

[0016] Figure 5 This utility model Figure 4 Side view;

[0017] Figure 6 This is a schematic diagram of the base structure in this utility model;

[0018] Figure 7 This is a schematic diagram of the sample holder structure in this utility model;

[0019] Figure 8 This is a schematic diagram of the cleaning tank in this utility model;

[0020] Figure 9 This is a top view of the cleaning tank in this utility model.

[0021] In the diagram: 1. Housing; 2. Dispensing needle; 3. Sample tube; 4. Cleaning tank; 5. Lifting and moving beam; 6. Limiting groove; 7. Sample rack; 8. Limiting block; 9. Limiting groove; 10. Cleaning tank; 11. Overflow hole; 12. Drain hole; 13. Peristaltic pump module; 14. Injection pump; 15. Three-way valve; 16. Syringe; 17. Observation window; 18. Moving crossbeam; 19. Moving longitudinal beam; 20. Base; 21. Rotary valve. Detailed Implementation

[0022] To more clearly illustrate the technical solution of this utility model, the following description is made in conjunction with the accompanying drawings. Obviously, the drawings described below are only one embodiment of this utility model. For those skilled in the art, other embodiments can be obtained based on these drawings and embodiments without creative effort, and all of them fall within the protection scope of this utility model.

[0023] according to Figure 1-9 As shown, a fully automatic liquid processing platform includes a housing 1, a dispensing needle 2 inside the housing 1, the dispensing needle 2 being mounted on a drive mechanism that drives it to move horizontally and vertically, a base 20 inside the housing 1, and a sample holder 7 on top of the base 20 for placing sample tubes 3. During the movement of the dispensing needle 2, liquid is added to the sample tubes 3. The dispensing needle 2 is connected to an infusion pump module. The housing 1 also includes a cleaning mechanism for cleaning the dispensing needle 2, the cleaning mechanism including a cleaning tank 4 for containing cleaning solution.

[0024] In the above specific technical solution, the dispensing needle 2 is driven by a driving mechanism to move along the horizontal X and Y axes and can also move along the vertical Z axis. During the movement, liquid is added to different sample tubes 3 through the infusion pump module. After one liquid is added, the dispensing needle 2 is cleaned through the cleaning tank 4. After cleaning, the dispensing needle 2 is used by the infusion pump module to add other sample liquids to the sample tubes 3 in sequence. This method of adding samples has high precision and high efficiency, thus improving the accuracy of experimental data.

[0025] The driving mechanism includes a lifting and moving beam 5 on which the dispensing needle 2 is slidably mounted. The lifting and moving beam 5 is slidably connected to the moving crossbeam 18, and the moving crossbeam 18 is slidably connected to the moving longitudinal beam 19. Through the driving mechanism, the dispensing needle 2 can move in the X, Y and Z axis directions.

[0026] The liquid dispensing needle 2 is moved along the X, Y and Z axes by a drive mechanism, which facilitates the sequential addition of samples from the sample tube 3 on the sample holder 7 by the liquid dispensing needle 2. The drive mechanism is existing technology. The lifting moving beam 5, the moving cross beam 18 and the moving longitudinal beam 19 can be equipped with a transmission mechanism of lead screw and motor, or a transmission mechanism of chain sprocket and motor. The specific structure will not be described in detail here.

[0027] The base 20 is provided with a positioning groove 6, the bottom of the sample rack 7 is provided with a support leg, the support leg of the sample rack 7 is inserted into the limiting groove 9, the front end of the sample rack 7 is provided with a limiting block 8, and the base 20 is provided with a limiting groove 9 that cooperates with the limiting block 8. The sample rack 7 is positioned by setting the limiting groove 9, and the cooperation between the limiting block 8 and the limiting groove 9 facilitates the accurate addition of samples by the dispensing needle 2. Preferably, different sample racks 7 can be placed, so that sample tubes 3 of different sizes can be placed on the sample rack 7. Furthermore, multiple sample racks 7 can be placed on the base 20 to further improve the efficiency of sample addition.

[0028] The cleaning tank 4 is provided with several cleaning tanks 10. The dispensing needle 2 is inserted into the cleaning tank 10 for cleaning. The side wall of the cleaning tank 4 is provided with an overflow hole 11 that communicates with the cleaning tank 10. The cleaning tank 4 is provided with a drain hole 12 below the overflow hole 11. The overflow hole 11 and the drain hole 12 are connected to the pipeline. When the height of the cleaning liquid reaches the height of the overflow hole 11, the cleaning liquid is discharged through the overflow hole 11 to prevent the cleaning liquid in the cleaning tank 4 from being too much. When the dispensing needle 2 is inserted into the cleaning tank 10, the cleaning liquid overflows from the top of the cleaning tank 4. The drain hole 12 is close to the bottom of the cleaning tank 10. When the cleaning liquid needs to be replaced, the cleaning liquid is discharged through the drain hole 12.

[0029] The cleaning tank 4 is connected to the peristaltic pump module 13 via a pipeline, and the peristaltic pump module 13 pumps and draws cleaning fluid into the cleaning tank 4.

[0030] The infusion pump module includes several injection pumps 14. Each injection pump 14 is connected to a rotary valve 21 and a corresponding syringe 16 via a three-way valve 15. Each injection pump 14 is equipped with a three-way valve 15 to switch between aspiration and dispensing of liquid. In addition, multiple rotary valves 21 can be used to select the injection pump 14 and the solvent, ensuring the orderly progress of the sample addition work and enabling the addition of various liquids.

[0031] An observation window 17 is provided on the outer wall of the housing 1 to facilitate observation of the sample addition process inside the housing 1.

[0032] Furthermore, the housing 1 is equipped with a control module, which mainly uses a PLC module to control the operation of the whole machine. The outer wall of the housing 1 is also equipped with an operation panel, which uses a 15-inch large screen. All liquid configuration schemes can be set by the customer on the screen. After the settings are completed, the software automatically calculates the type and volume of liquid to be aspirated and directs the three-axis and pump valve module to cooperate in completing the liquid aspiration and discharge actions.

[0033] The above embodiments are merely exemplary embodiments of the present utility model and are not intended to limit the present utility model. The scope of protection of the present utility model is defined by the claims. Those skilled in the art can make various modifications or equivalent substitutions to the present utility model within its substance and scope of protection, and such modifications or equivalent substitutions should also be considered to fall within the scope of protection of the present utility model.

Claims

1. A fully automated liquid handling platform, comprising a housing (1), characterized in that, The housing (1) is provided with a dispensing needle (2), which is installed in a drive mechanism that drives it to move horizontally and vertically. The housing (1) is provided with a base (20), and the top of the base (20) is used to place a sample holder (7) for the sample tube (3). The dispensing needle (2) adds liquid to the sample tube (3) during the movement. The dispensing needle (2) is connected to the infusion pump module pump. The housing (1) is also provided with a cleaning mechanism for cleaning the dispensing needle (2), which includes a cleaning pool (4) for containing cleaning liquid.

2. The fully automated liquid handling platform according to claim 1, characterized in that, The driving mechanism includes a lifting and moving beam (5) on which the dispensing needle (2) is slidably mounted. The lifting and moving beam (5) is slidably connected to the moving crossbeam (18), and the moving crossbeam (18) is slidably connected to the moving longitudinal beam (19). Through the driving mechanism, the dispensing needle (2) is moved in the X, Y and Z axis directions.

3. The fully automated liquid handling platform according to claim 1, characterized in that, The base (20) is provided with a positioning groove (6), the bottom of the sample holder (7) is provided with a support leg, the support leg of the sample holder (7) is inserted into the limiting groove (9), the front end of the sample holder (7) is provided with a limiting block (8), and the base (20) is provided with a limiting groove (9) that cooperates with the limiting block (8).

4. The fully automated liquid handling platform according to claim 1, characterized in that, The cleaning tank (4) is provided with several cleaning tanks (10). The liquid dispensing needle (2) is inserted into the cleaning tank (10) for cleaning. The side wall of the cleaning tank (4) is provided with an overflow hole (11) that communicates with the cleaning tank (10). The cleaning tank (4) is provided with a drain hole (12) below the overflow hole (11). The overflow hole (11) and the drain hole (12) are connected to the pipeline.

5. The fully automated liquid handling platform according to claim 1, characterized in that, The cleaning tank (4) is connected to the peristaltic pump module (13) through a pipeline, and the peristaltic pump module (13) pumps and draws cleaning fluid into the cleaning tank (4).

6. The fully automated liquid handling platform according to claim 1, characterized in that, The infusion pump module includes several injection pumps (14), which are connected to a rotary valve (21) and a corresponding syringe (16) via a three-way valve (15).

7. The fully automated liquid handling platform according to claim 6, characterized in that, An observation window (17) is provided on the outer wall of the housing (1).

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