A storage mechanism for use in an intermediate of apixaban

Abstract

The utility model relates to apixaban intermediate storage technical field, specifically, relate to a kind of for apixaban intermediate storage mechanism. Including refrigerator. The utility model discloses when rotating, two driven bevel gears respectively drive corresponding threaded rod synchronous reverse rotation, drive two U-shaped frame and the clamping plate connected therewith mutually close, to be clamped and fixed by the rubber pad on clamping plate with several square containers placed side by side on the plate body upper surface, simultaneously the movement of U-shaped frame synchronous drive corresponding piston rod and rubber head to the direction of sliding away from suction cup, so that the space between rubber head and suction cup inside circular pipe is increased, and then form negative pressure in the space and suction cup inside, suction cup is firmly adsorbed on the smooth inner wall of refrigerator, to stabilize the plate body in the predetermined position inside refrigerator, effectively limit the movement of square container inside refrigerator, improve the security of apixaban intermediate stored in square container during transfer.

Description

Technical Field

[0001] This utility model relates to the field of apixaban intermediate storage technology, and more specifically, to a storage mechanism for apixaban intermediates. Background Technology

[0002] Apixaban is an important oral anticoagulant drug. Its complex chemical synthesis involves a variety of intermediates, which are compounds located between the starting material and the final API, apixaban, in the synthetic pathway.

[0003] Apixaban intermediates need to be stored in a refrigerator at low temperatures. This is because some intermediate molecules in the apixaban synthesis process are relatively fragile and are prone to chemical decomposition or physical changes at room temperature, leading to decreased purity, increased impurities, or morphological changes. Storing these intermediates in the low-temperature environment of a refrigerator is to slow down the rate of these degradations and changes to the greatest extent possible, ensure the chemical and physical stability of the intermediates, extend their usability, and ultimately ensure the smooth progress of subsequent synthesis steps as well as the quality, safety, and efficacy of the final drug substance.

[0004] When apixaban intermediates need to be transported by truck, due to their stability requirements, they must be placed inside a truck refrigerator. To ensure the stability of the apixaban intermediates inside the refrigerator, they must be loaded into a square container and placed horizontally on the shelf inside the refrigerator. At the same time, to ensure that the circulating cold airflow inside the refrigerator can fully contact the bottom and side walls of the square container, thereby effectively cooling the container and its internal materials, a gap must be reserved between the bottom and side walls of the container and the inner wall of the refrigerator for the cold airflow to pass through. However, when the truck encounters bumps and vibrations during travel, this practice will transmit the vibrations to the inside of the refrigerator, causing the shelf and the square container on it to shift due to vibration. This shift can easily cause the container to collide with the inner wall of the refrigerator, or the containers to collide with each other. Such collisions will weaken the sealing performance of the square container, thereby increasing the risk of leakage of the apixaban intermediates inside. Summary of the Invention

[0005] The purpose of this invention is to provide a storage mechanism for apixaban intermediates to solve the problems mentioned in the background art.

[0006] When a transport vehicle encounters bumps and vibrations while driving, the vibrations are transmitted to the interior of the vehicle refrigerator, causing the shelf and the square containers on it to shift due to the vibrations. This can lead to collisions between the containers and the inner wall of the refrigerator, or between the containers themselves. Such collisions can weaken the sealing performance of the square containers, thereby increasing the risk of leakage of the apixaban intermediate inside.

[0007] To address the above problems, the present invention aims to provide a storage mechanism for apixaban intermediates, comprising a refrigerator. The refrigerator has several horizontally arranged slots vertically arrayed on opposite sides inside. A shelf is provided inside the refrigerator, comprising a horizontally arranged plate. The two sides of the plate are slidably disposed in two slots at the same height. Two clamping plates are symmetrically slidably disposed on the upper sidewall of the plate. Rubber pads are fixedly disposed on the sides of the two clamping plates that are close to each other. Movable grooves are provided on the plate at positions corresponding to the ends of the clamping plates. The lower sidewall of the plate corresponds to the two clamping plates. U-shaped frames are slidably installed at each position. Both ends of the U-shaped frames are fixedly connected to the lower sidewall of the corresponding clamping plate, and both ends of the U-shaped frames are slidably installed inside the corresponding movable grooves. An adjustment mechanism is provided on the lower side of the plate. The adjustment mechanism is used to move the two U-shaped frames away from each other or closer to each other. Two adsorption mechanisms are provided on the side of the two U-shaped frames that are far apart from each other. When the adjustment mechanism moves the two U-shaped frames closer to each other, the U-shaped frames move the corresponding clamping plates synchronously, so that the two rubber pads clamp and fix several square containers placed side by side on the upper sidewall of the plate. At the same time, the adsorption mechanism adsorbs and fixes the plate to the inner wall of the refrigerator.

[0008] As a further improvement to this technical solution, the adjusting mechanism includes two threaded rods that are symmetrically and horizontally rotatably disposed on the lower side wall of the plate, and the two U-shaped frames are respectively threadedly connected to the two threaded rods.

[0009] As a further improvement to this technical solution, each of the two adjacent threaded rods is coaxially and fixedly connected to a driven bevel gear at one end. A rotating rod is horizontally rotatably provided on the lower side wall of the plate. One end of the rotating rod is coaxially and fixedly connected to a driving bevel gear, which meshes with the two driven bevel gears.

[0010] As a further improvement to this technical solution, the adsorption mechanism includes a circular tube that is horizontally fixedly installed on the lower side wall of the plate. A suction cup is fixedly connected to one end of the circular tube away from the U-shaped frame, and the other end of the suction cup is in contact with the inner wall of the refrigerator.

[0011] As a further improvement to this technical solution, the adsorption mechanism also includes a piston rod slidably disposed inside the circular tube. A rubber head is fixedly connected to one end of the piston rod near the suction cup, and a U-shaped frame is fixedly connected to the other end of the piston rod away from the suction cup. The circumferential sidewalls of the piston rod and the rubber head are slidably connected to the inner circumferential wall of the circular tube.

[0012] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0013] 1. This storage mechanism for apixaban intermediates, when the rotating rod rotates, causes two driven bevel gears to drive their corresponding threaded rods to rotate synchronously in opposite directions, driving two U-shaped frames and their connected clamping plates to move closer together. This clamps several square containers placed side-by-side on the upper surface of the plate with rubber pads on the clamping plates. Simultaneously, the movement of the U-shaped frames drives the corresponding piston rods and rubber heads to slide away from the suction cups, increasing the space between the rubber heads and suction cups inside the round tube. This creates a negative pressure within the space and inside the suction cups, causing the suction cups to firmly adhere to the smooth inner wall of the refrigerator under atmospheric pressure. This stabilizes the plate in a predetermined position inside the refrigerator, effectively limiting the movement of the square containers inside the refrigerator and preventing a decrease in sealing due to collisions between the square containers and the refrigerator's inner wall. This improves the safety of the apixaban intermediates stored inside the square containers during transport. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0015] Figure 2 This is one of the structural schematic diagrams of the storage rack of this utility model;

[0016] Figure 3 This is the second structural schematic diagram of the storage rack of this utility model;

[0017] Figure 4 This is a partial structural diagram of the storage rack of this utility model;

[0018] Figure 5 This is a schematic diagram of the adsorption mechanism of this utility model;

[0019] Figure 6 This is an exploded view of the adsorption mechanism of this utility model.

[0020] The meanings of the labels in the diagram are as follows:

[0021] 1. Refrigerator; 11. Card slot;

[0022] 2. Shelf; 21. Panel; 22. Movable groove; 23. Clamping plate; 231. Rubber pad; 24. Threaded rod; 25. Driven bevel gear; 26. Rotating rod; 27. Driven bevel gear; 28. U-shaped frame;

[0023] 3. Adsorption mechanism; 31. Circular tube; 32. Suction cup; 33. Piston rod; 34. Rubber head. Detailed Implementation

[0024] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model. Example

[0025] Please see Figure 1 As shown, the purpose of this embodiment is to provide a storage mechanism for apixaban intermediates, including a refrigerator 1. The refrigerator 1 is a small-sized commercially available mature product. The refrigerator 1 is fixedly installed inside the compartment of a transport vehicle. Several horizontally arranged slots 11 are vertically arrayed on both opposite sides of the refrigerator 1. The refrigerator 1 is equipped with a shelf 2. The shelf 2 includes a horizontally arranged plate 21. The two sides of the plate 21 are slidably arranged in two slots 11 at the same height. The slots 11 support the two sides of the plate 21, thereby stably positioning the plate 21 at the required height.

[0026] When using this device, multiple shelves 2 can be installed inside the refrigerator 1. These shelves 2 are inserted into different heights inside the refrigerator 1 via slots 11. The operator places the square glass container containing the apixaban intermediate horizontally and side by side on the upper side wall of the plate 21, and the refrigerator 1 can be used for cold storage. This structural design can ensure that the apixaban intermediate remains stable during long-term storage.

[0027] Several vertically penetrating ventilation slots are provided on the plate 21. At the same time, gaps are left between both ends of the square container placed on the plate 21 and the inner wall of the refrigerator 1. This design allows the cold air circulating inside the refrigerator 1 to flow smoothly downward through the ventilation slots on the plate 21 and continue to flow through the gaps between the container ends and the inner wall of the refrigerator 1. The flowing cold air can more effectively remove the heat (convective heat transfer) from the square container wall and the internal material. Compared with static air, the flowing air can improve the heat transfer efficiency. The continuous channel formed by the ventilation slots and the end gaps ensures that the cold air can continuously contact the bottom of the container and carry out sufficient heat exchange, thereby achieving faster and more uniform cooling and significantly enhancing the cooling effect of the refrigerator 1 on the apixaban intermediate stored inside the square container.

[0028] When refrigerator 1 is fixedly installed on a transport vehicle for transporting apixaban intermediates, the bumps and vibrations during the transport vehicle's journey will be transmitted to the interior of refrigerator 1. This causes the square container placed on plate 21 to be easily affected by the vibration and shift, which may then cause it to collide with the inner wall of refrigerator 1 or with each other. Such collisions will reduce the sealing of the square container and increase the risk of leakage of the apixaban intermediates inside.

[0029] To solve the above problems, refer to Figure 2 Two clamping plates 23 are symmetrically slidably arranged on the upper side wall of the plate 21. Rubber pads 231 are fixedly arranged on the side of the two clamping plates 23 that are close to each other. Movable grooves 22 are opened on the plate 21 at the positions corresponding to the two ends of the clamping plates 23. U-shaped frames 28 are slidably arranged on the lower side wall of the plate 21 at the positions corresponding to the two clamping plates 23. The two ends of the U-shaped frames 28 are fixedly connected to the lower side wall of the corresponding clamping plates 23, and the two ends of the U-shaped frames 28 are slidably arranged inside the corresponding movable grooves 22. The movable grooves 22 restrict the U-shaped frames 28 and the clamping plates 23 to move only horizontally. An adjustment mechanism is provided on the lower side of the plate 21. The adjustment mechanism is used to drive the two U-shaped frames 28 to move away from each other or closer to each other. At the same time, two adsorption mechanisms 3 are provided on the side of the two U-shaped frames 28 that are far apart from each other.

[0030] When several square containers need to be fixed to the plate 21, the operator first inserts a rubber partition between each pair of adjacent square containers. Then, the adjusting mechanism drives two U-shaped frames 28 to move closer to each other. The U-shaped frames 28 drive the corresponding clamping plates 23 to move synchronously, and the rubber pads 231 on the clamping plates 23 move synchronously, so that the two rubber pads 231 clamp and fix the several square containers placed side by side on the upper side wall of the plate 21. At this time, the two rubber pads 231 are in close contact with the side walls of the two outermost square containers, and the distance between adjacent square containers is reduced, so that the adjacent two square containers are also in close contact with the rubber partitions between them. The rubber pads 231 and the rubber partitions generate a large frictional force with the glass square containers, thereby firmly fixing the entire row of square containers to the plate 21. At the same time, the adsorption mechanism 3 adsorbs and fixes the plate 21 to the inner wall of the refrigerator 1. This double fixing mechanism effectively restricts the movement of the square containers inside the refrigerator 1 and avoids the problem of reduced sealing caused by the collision between the square containers and the inner wall of the refrigerator 1.

[0031] The following details the structure of the adjusting mechanism, referring to... Figure 3 and Figure 4 The adjustment mechanism includes two threaded rods 24 that are symmetrically and horizontally rotatably mounted on the lower side wall of the plate 21. Two U-shaped brackets 28 are threadedly connected to the two threaded rods 24 respectively. The ends of two adjacent threaded rods 24 that are close to each other are coaxially fixedly connected to driven bevel gears 25. A rotating rod 26 is horizontally rotatably mounted on the lower side wall of the plate 21. One end of the rotating rod 26 is coaxially fixedly connected to a driving bevel gear 27. The driving bevel gear 27 meshes with the two driven bevel gears 25. The opening of the refrigerator 1 is located on the side, and the axis of the rotating rod 26 passes through this opening (the position of the refrigerator door). The end of the rotating rod 26 near the opening of the refrigerator 1 extends to the outside of the plate 21 and is coaxially fixedly connected to a bolt head.

[0032] The operator uses an electric screwdriver to drive the bolt head to rotate, which in turn drives the rotating rod 26 and the driving bevel gear 27 to rotate. Through the meshing transmission between the driving bevel gear 27 and the two driven bevel gears 25, the two driven bevel gears 25 drive the corresponding threaded rods 24 to rotate synchronously in opposite directions. The threads on the two threaded rods 24 are in the same direction. Through the threaded engagement between the threaded rods 24 and the corresponding U-shaped frame 28, the two U-shaped frames 28 are driven to move horizontally in opposite directions. The two U-shaped frames 28 drive the corresponding clamping plates 23 to move closer to each other, thereby clamping and fixing several square containers placed side by side on the upper side wall of the plate 21.

[0033] The structure of adsorption mechanism 3 is detailed below, referring to... Figure 5 and Figure 6 The adsorption mechanism 3 includes a circular tube 31 horizontally fixedly installed on the lower side wall of the plate 21. One end of the circular tube 31 away from the U-shaped frame 28 is fixedly connected to a suction cup 32 made of polyurethane. The other end of the suction cup 32 contacts the inner wall of the refrigerator 1, and a silicone pad is attached to the contact surface between the suction cup 32 and the inner wall of the refrigerator 1. When the operator inserts the two sides of the plate 21 into the two slots 11 of the same height, the suction cup 32 contacts the inner wall of the refrigerator 1, and the silicone pad on the suction cup 32 undergoes elastic deformation, minimizing the gap between the suction cup 32 and the inner wall of the refrigerator 1. It should be noted that the outer diameter of the suction cup 32 is smaller than the distance between the two adjacent upper and lower slots 11. Therefore, the position where the suction cup 32 contacts the inner wall of the refrigerator 1 is exactly between the two adjacent upper and lower slots 11.

[0034] The adsorption mechanism 3 also includes a piston rod 33 that is slidably disposed inside the circular tube 31. A rubber head 34 is fixedly connected to one end of the piston rod 33 near the suction cup 32, and the other end of the piston rod 33 away from the suction cup 32 is fixedly connected to the U-shaped frame 28. The circumferential sidewalls of the piston rod 33 and the rubber head 34 are slidably connected to the circumferential inner wall of the circular tube 31.

[0035] When the two U-shaped frames 28 move the corresponding clamps 23 closer to each other, the U-shaped frames 28 simultaneously drive the corresponding piston rods 33 and rubber heads 34 to slide away from the suction cups 32. This action causes the space between the rubber heads 34 and the suction cups 32 in the round tube 31 to increase, thereby creating a negative pressure in this space and inside the suction cups 32. Because the suction cups 32 maintain a very small gap with the inner wall of the refrigerator 1 through the elastic deformation of the silicone pad, external air can only seep in at an extremely slow speed to replenish it. Thus, under the action of the pressure difference between the inside and outside, the suction cups 32 are firmly attached to the smooth inner wall of the refrigerator 1. Through the adsorption and fixing effect between the suction cups 32 and the inner wall of the refrigerator 1, the plate 21 is stabilized in the predetermined position inside the refrigerator 1. This effectively prevents the plate 21 from causing the square container to shift, thereby avoiding the problem of the square container colliding with the inner wall of the refrigerator 1 and causing its sealing performance to decrease.

[0036] When this device is in use, when the rotating rod 26 rotates, the two driven bevel gears 25 drive the corresponding threaded rods 24 to rotate synchronously in opposite directions, causing the two U-shaped frames 28 and their connected clamping plates 23 to move closer to each other. This clamps and fixes several square containers placed side by side on the upper surface of the plate 21 through the rubber pads 231 on the clamping plates 23. At the same time, the movement of the U-shaped frames 28 synchronously drives the corresponding piston rods 33 and rubber heads 34 to slide away from the suction cups 32, increasing the space between the rubber heads 34 and the suction cups 32 inside the round tube 31. This creates a negative pressure in the space and inside the suction cups 32. Under atmospheric pressure, the suction cups 32 are firmly adsorbed onto the smooth inner wall of the refrigerator 1, thus fixing the plate 21 inside the refrigerator 1. This design effectively limits the shaking of the square containers inside the refrigerator 1 and avoids the problem of reduced sealing caused by the collision between the square containers and the inner wall of the refrigerator 1. Therefore, it improves the safety of the apixaban intermediate stored inside the square containers during the transportation process.

[0037] It should be noted that the spacing between several slots 11 on the same side of the refrigerator 1 is sufficient for the suction cup 32 to adhere, thereby ensuring the positioning effect of the suction mechanism 3 on the plate 21.

[0038] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely preferred examples and are not intended to limit the utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claimed utility model. The scope of protection of this utility model is defined by the appended claims and their equivalents.

Claims

1. A storage mechanism for use in intermediates of Apixaban comprising a refrigerator (1) characterized in that: The refrigerator (1) has several horizontally arranged slots (11) vertically arranged on both sides inside. The refrigerator (1) has a shelf (2) inside. The shelf (2) includes a horizontally arranged plate (21). The two sides of the plate (21) are respectively slidably arranged in two slots (11) at the same height. The upper side wall of the plate (21) is symmetrically arranged with two clamps (23). Rubber pads (231) are fixedly arranged on the side of the two clamps (23) that are close to each other. Movable grooves (22) are opened on the plate (21) at the positions corresponding to the two ends of the clamps (23). U-shaped frames (28) are slidably arranged on the lower side wall of the plate (21) at the positions corresponding to the two clamps (23). Both ends of the U-shaped frame (28) are fixedly connected to the lower side wall of the corresponding clamping plate (23), and both ends of the U-shaped frame (28) are slidably set inside the corresponding movable groove (22). The lower side of the plate (21) is provided with an adjustment mechanism. The adjustment mechanism is used to drive the two U-shaped frames (28) to move away from each other or to move closer to each other. Two adsorption mechanisms (3) are provided on the side of the two U-shaped frames (28) that move away from each other. When the adjustment mechanism drives the two U-shaped frames (28) to move closer to each other, the U-shaped frame (28) drives the corresponding clamping plate (23) to move synchronously, so that the two rubber pads (231) clamp and fix several square containers placed side by side on the upper side wall of the plate (21). At the same time, the adsorption mechanism (3) adsorbs and fixes the plate (21) to the inner wall of the refrigerator (1).

2. The storage mechanism for apixaban intermediate as claimed in claim 1 wherein: The adjusting mechanism includes two threaded rods (24) that are symmetrically and horizontally rotated on the lower side wall of the plate (21), and the two U-shaped frames (28) are respectively threadedly connected to the two threaded rods (24).

3. The storage mechanism for apixaban intermediate as claimed in claim 2 wherein: Two adjacent threaded rods (24) are coaxially fixedly connected to one end of each other with a driven bevel gear (25). The lower side wall of the plate (21) is horizontally rotatably provided with a rotating rod (26). One end of the rotating rod (26) is coaxially fixedly connected to a driving bevel gear (27). The driving bevel gear (27) meshes with the two driven bevel gears (25).

4. The storage mechanism for apixaban intermediate as claimed in claim 1 wherein: The adsorption mechanism (3) includes a round tube (31) that is horizontally fixedly installed on the lower side wall of the plate (21). A suction cup (32) is fixedly connected to one end of the round tube (31) away from the U-shaped frame (28), and the other end of the suction cup (32) is in contact with the inner wall of the refrigerator (1).

5. The storage mechanism for apixaban intermediates according to claim 4, characterized in that: The adsorption mechanism (3) further includes a piston rod (33) slidably disposed inside the circular tube (31). A rubber head (34) is fixedly connected to one end of the piston rod (33) near the suction cup (32), and the other end of the piston rod (33) away from the suction cup (32) is fixedly connected to the U-shaped frame (28). The circumferential sidewalls of the piston rod (33) and the rubber head (34) are slidably connected to the inner circumferential wall of the circular tube (31).

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