A ureteral delivery device adapted for antimicrobial microsphere sustained release

Abstract

The utility model relates to the technical field of medicine delivery device, concretely to a kind of ureter delivery device suitable for antibacterial microsphere sustained release, including delivery structure and delivery pipe, delivery structure includes liquid storage cylinder, the left end of liquid storage cylinder is threadedly connected with cylinder cover, the left end of cylinder cover is equipped with connecting end, the input end of delivery pipe is equipped with the connecting sleeve threadedly connected with connecting end, piston for pushing antibacterial microsphere is equipped in liquid storage cylinder, the right side of piston is connected with push rod by bolt, the right end of push rod passes through the inner wall of liquid storage cylinder to outside, the lower portion of liquid storage cylinder is equipped with uniform speed drive structure for driving push rod left and right movement.The ureter delivery device suitable for antibacterial microsphere sustained release, the advancing speed of piston is controlled by uniform speed drive structure, and the physical speed-limiting effect of porous septum to microsphere passing is combined, antibacterial microsphere can be continuously released into urinary tract at constant and slow rate, overcome the problem of drug concentration sudden rise and sudden drop in traditional administration mode.

Description

Technical Field

[0001] This utility model relates to the field of drug delivery device technology, specifically a ureteral delivery device adapted for sustained release of antibacterial microspheres. Background Technology

[0002] Antimicrobial microspheres are a novel drug delivery system composed of a polymer substrate. They effectively encapsulate and sustain the release of antimicrobial drugs, offering significant advantages over traditional antimicrobial treatments. They achieve more stable drug concentrations in vivo and prolong the duration of drug action. Furthermore, the size and shape of the antimicrobial microspheres can be adjusted to meet specific treatment needs, thereby improving targeting and therapeutic efficacy. This microsphere technology shows great potential in antimicrobial therapy, particularly in the treatment of diseases such as urinary tract infections.

[0003] However, existing antibacterial treatments still face some challenges. Traditional administration methods often result in insufficient effective drug concentrations in the body, and the drugs have short half-lives, requiring patients to take them frequently. This not only increases the burden of medication for patients but may also lead to fluctuations in antibacterial efficacy, thus affecting the effectiveness of treatment. In addition, insufficient drug concentrations may also promote the emergence of drug-resistant strains.

[0004] To address the aforementioned issues, we propose a ureteral delivery device adapted for sustained release of antibacterial microspheres. This device aims to achieve a sustained antibacterial effect by controlling the release of antibacterial microspheres within the urinary tract, thus solving the problems of insufficient drug concentration and short duration of action in traditional treatments, and thereby improving the therapeutic efficacy of urinary tract infections. Utility Model Content

[0005] The purpose of this invention is to provide a ureteral delivery device adapted for sustained release of antibacterial microspheres, in order to solve the problems mentioned in the background art, which often lead to insufficient effective drug concentration in the body and short drug half-life, requiring patients to take the drug frequently. This not only increases the patient's medication burden, but may also lead to fluctuations in antibacterial effect, thereby affecting the effectiveness of treatment.

[0006] To achieve the above objectives, this utility model provides the following technical solution:

[0007] A ureteral delivery device adapted for sustained release of antibacterial microspheres includes a delivery structure and a delivery tube. The delivery tube guides a microsphere mixture into a flexible channel within the patient's body. The delivery structure includes a reservoir for containing a pre-prepared mixture of antibacterial microspheres and a carrier fluid. A cap is threaded to the left end of the reservoir, serving to seal the reservoir and house key filtration and monitoring elements. A connecting end is provided at the left end of the cap. The input end of the delivery tube is provided with a connecting sleeve threaded to the connecting end, achieving a reliable and detachable connection.

[0008] The liquid storage cylinder is equipped with a piston for pushing antibacterial microspheres. A push rod is bolted to the right side of the piston. The right end of the push rod passes through the inner wall of the liquid storage cylinder to the outside, transmitting the linear motion of the external drive structure to the piston. A uniform speed drive structure is provided below the liquid storage cylinder for driving the push rod to move left and right, providing a stable power source for the pushing action.

[0009] Preferably, the inner wall of the cap is provided with a porous membrane with a pore size of 50-200 micrometers, which allows only the liquid and dispersed microspheres to pass through. The release rate of the microspheres is physically regulated by the specific pore size to achieve slow release. The inner wall of the cap is also provided with a pressure sensor to monitor the fluid pressure at the liquid outlet of the delivery structure in real time. This pressure data is a key signal for feedback on the pushing speed and ensuring smooth release.

[0010] Preferably, a first sealing gasket is bonded to the left end of the liquid storage cylinder. The left side of the first sealing gasket abuts against the right edge of the porous diaphragm to seal the connection gap between the liquid storage cylinder body and the cylinder cover, preventing the mixture from leaking out from there, and at the same time assisting in pressing and fixing the edge of the porous diaphragm.

[0011] Preferably, a second sealing gasket is bonded to the left end of the connecting end, and the second sealing gasket fills the gap between the connecting end and the connecting sleeve.

[0012] Preferably, an injection pipe is provided on the outer wall of the liquid storage cylinder near the left end, serving as a channel for injecting the microsphere mixture into the liquid storage cylinder. The injection pipe is threaded with a sealing cap and is located to the right of the porous diaphragm. This position ensures that the injected liquid and microspheres directly enter the main chamber of the liquid storage cylinder and must pass through the porous diaphragm before flowing out.

[0013] Preferably, the uniform speed driving structure includes a mounting plate, and a rectangular horizontal tube is bolted to the right side of the mounting plate. A rectangular movable rod is movably connected inside the rectangular horizontal tube. Its rectangular cross section cooperates with the rectangular horizontal tube to prevent it from rotating and can only slide axially. A connecting rod is provided at the right end of the rectangular movable rod.

[0014] Preferably, a rubber ring is provided at the connection between the push rod and the liquid storage cylinder as a dynamic seal. While allowing the push rod to move axially, it effectively seals the gap between the push rod and the hole in the wall of the liquid storage cylinder to prevent liquid leakage. The right end of the push rod is connected to the connecting rod by bolts for easy disassembly and maintenance.

[0015] Preferably, a motor is provided on the left side of the mounting plate, the output shaft of the motor passes through the left side of the mounting plate and is coaxially connected to a lead screw, and the rectangular movable rod is threaded to the outside of the lead screw. Through the principle of the lead screw and nut pair, the rotation of the lead screw is converted into the linear movement of the rectangular movable rod along the rectangular horizontal tube.

[0016] Preferably, a U-shaped base is provided below the conveying structure, and the mounting plate is installed on the inner side of the U-shaped base by bolts, so as to firmly fix the drive module in the base frame and form an integral frame.

[0017] Preferably, the top of the U-shaped base is provided with two symmetrically arranged support inclined plates. The liquid storage cylinder is bonded between the two support inclined plates. The inclined surface of the support inclined plates is designed to support and fix the cylindrical liquid storage cylinder, so that it is placed stably at a specific angle and to prevent rolling.

[0018] Compared with the prior art, the beneficial effects of this utility model are:

[0019] 1. This ureteral delivery device for sustained release of antibacterial microspheres controls the piston's advance speed through a uniform drive structure, and combines the physical speed-limiting effect of a porous diaphragm on the passage of microspheres. This allows the antibacterial microspheres to be continuously released into the urinary tract at a constant and slow rate, overcoming the problem of sudden rises and falls in drug concentration in traditional drug delivery methods. It can maintain an effective therapeutic concentration at the lesion site for a long time, thereby significantly improving the antibacterial efficacy and reducing the risk of treatment failure or drug resistance caused by concentration fluctuations.

[0020] 2. This ureteral delivery device with adaptive antibacterial microsphere sustained release stores antibacterial microspheres in a reservoir and provides long-term drug delivery in one go through a mechanical sustained release mechanism, avoiding the inconvenience of patients needing to take medication frequently or change the drug bag.

[0021] 3. The ureter delivery device with antibacterial microsphere sustained release has a pressure sensor integrated into the inner wall of the cap that can monitor the fluid pressure at the outlet of the delivery system in real time. This pressure signal can be used as a feedback parameter. If an abnormal increase in pressure is detected (which may indicate ureteral blockage or poor release), the device can be linked to control the uniform drive structure to adjust or pause the push, thereby avoiding tissue damage caused by excessive intracavitary pressure. Attached Figure Description

[0022] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0023] Figure 2 This is a schematic diagram of the overall cross-sectional structure of this utility model;

[0024] Figure 3 This is a partial assembly structure diagram of the present invention;

[0025] Figure 4 This is a schematic cross-sectional view of the liquid storage cylinder and rectangular horizontal tube in this utility model.

[0026] Figure 5 This is a schematic diagram of the U-shaped base structure in this utility model;

[0027] In the diagram: 100, conveying structure; 110, liquid storage cylinder; 120, cylinder cover; 121, connecting end; 130, piston; 140, first sealing gasket; 150, injection pipe; 160, sealing cap; 170, push rod; 180, rubber ring; 200, conveying pipe; 210, connecting sleeve; 300, uniform speed drive structure; 310, mounting plate; 320, rectangular horizontal tube; 330, rectangular movable rod; 340, lead screw; 350, motor; 360, connecting rod; 400, porous diaphragm; 500, second sealing gasket; 600, U-shaped base; 610, supporting inclined plate. Detailed Implementation

[0028] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0029] In the description of this utility model, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", etc., indicating the orientation or positional relationship are based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this utility model and simplifying the description, and are not intended to indicate or imply that the device or component referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model.

[0030] See appendix Figure 1-2 A ureteral delivery device adapted for sustained release of antibacterial microspheres includes a delivery structure 100 and a delivery tube 200. The delivery tube 200 guides the microsphere mixture into a flexible channel within the patient's body. The delivery structure 100 includes a reservoir 110 for containing a pre-prepared mixture of antibacterial microspheres and a carrier fluid. A cap 120 is threaded to the left end of the reservoir 110, which serves to seal the reservoir 110 and install key filtering and monitoring elements. A connecting end 121 is provided at the left end of the cap 120. A connecting sleeve 210 is threaded to the connecting end 121 at the input end of the delivery tube 200, achieving a reliable and detachable connection.

[0031] The liquid storage cylinder 110 is equipped with a piston 130 for pushing antibacterial microspheres. A push rod 170 is bolted to the right side of the piston 130. The right end of the push rod 170 passes through the inner wall of the liquid storage cylinder 110 to the outside, transmitting the linear motion of the external drive structure to the piston 130. A uniform speed drive structure 300 is provided below the liquid storage cylinder 110 for driving the push rod 170 to move left and right, providing a stable power source for the pushing action.

[0032] See appendix Figure 3 The cap 120 is equipped with a porous diaphragm 400 with a pore size of 50-200 micrometers, which only allows the liquid and dispersed microspheres to pass through. The release rate of the microspheres is physically regulated by the specific pore size to achieve slow release. The inner wall of the cap 120 is also equipped with a pressure sensor to monitor the fluid pressure at the liquid outlet of the delivery structure 100 in real time. This pressure data is a key signal for feedback on the pushing speed and ensuring smooth release.

[0033] Importantly, a first sealing gasket 140 is bonded to the left end of the liquid storage cylinder 110. The left side of the first sealing gasket 140 abuts against the right edge of the porous diaphragm 400 to seal the connection gap between the cylinder body of the liquid storage cylinder 110 and the cylinder cover 120, preventing the mixture from leaking out from there, and at the same time helping to press and fix the edge of the porous diaphragm 400.

[0034] More specifically, a second sealing gasket 500 is bonded to the left end of the connecting end 121, and the second sealing gasket 500 fills the gap between the connecting end 121 and the connecting sleeve 210.

[0035] See appendix Figure 2 An injection pipe 150 is provided on the outer wall of the liquid storage cylinder 110 near the left end, serving as a channel for injecting the microsphere mixture into the liquid storage cylinder 110. The injection pipe 150 is threadedly connected to a sealing cap 160. The injection pipe 150 is located to the right of the porous diaphragm 400. This position ensures that the injected liquid and microspheres directly enter the main chamber of the liquid storage cylinder 110 and must pass through the porous diaphragm 400 before flowing out.

[0036] See appendix Figure 4 The uniform speed drive structure 300 includes a mounting plate 310. A rectangular horizontal tube 320 is bolted to the right side of the mounting plate 310. A rectangular movable rod 330 is movably connected inside the rectangular horizontal tube 320. Its rectangular cross section cooperates with the rectangular horizontal tube 320 to prevent itself from rotating and can only slide axially. A connecting rod 360 is provided at the right end of the rectangular movable rod 330.

[0037] More specifically, a rubber ring 180 is provided at the connection between the push rod 170 and the liquid storage cylinder 110 as a dynamic seal. While allowing the push rod 170 to move axially, it effectively seals the gap between the push rod 170 and the wall hole of the liquid storage cylinder 110 to prevent liquid leakage. The right end of the push rod 170 is connected to the connecting rod 360 by bolts for easy disassembly and maintenance.

[0038] In a more detailed embodiment, a motor 350 is provided on the left side of the mounting plate 310. The output shaft of the motor 350 passes through the left side of the mounting plate 310 and is coaxially connected to a lead screw 340. A rectangular movable rod 330 is threaded to the outside of the lead screw 340. Through the principle of the lead screw and nut pair, the rotation of the lead screw 340 is converted into the linear movement of the rectangular movable rod 330 along the rectangular horizontal tube 320.

[0039] See appendix Figure 5 A U-shaped base 600 is provided below the conveying structure 100. The mounting plate 310 is installed on the inside of the U-shaped base 600 by bolts, which firmly fixes the drive module in the base frame to form an integral frame.

[0040] More specifically, the top of the U-shaped base 600 is provided with two symmetrically arranged support inclined plates 610. The liquid storage cylinder 110 is bonded between the two support inclined plates 610. The inclined surface of the support inclined plate 610 is designed to support and fix the cylindrical liquid storage cylinder 110, so that it is placed stably at a specific angle and prevents it from rolling.

[0041] It should be noted that the motor 350 and pressure sensor in this utility model are both externally powered and controlled by a controller. All components are general standard parts or parts known to those skilled in the art. Their structure and principles can be learned by those skilled in the art through technical manuals or conventional experimental methods. The specific connection methods should refer to the working sequence of each electrical component in the above working principle to complete the electrical connection. The detailed connection methods are known technologies in the field. The above mainly introduces the working principle and process, and will not explain the electrical control. The contents not described in detail in this description belong to the prior art known to those skilled in the art.

[0042] In this embodiment, the ureteral delivery device adapted for sustained release of antibacterial microspheres is used as follows: First, the connecting sleeve 210 at the input end of the delivery tube 200 is threadedly connected to the connecting end 121 at the left end of the cap 120, and the second sealing washer 500 ensures a tight seal at the connection. Next, the sealing cap 160 on the injection tube 150 is unscrewed, and the pre-prepared mixture of antibacterial microspheres and carrier fluid is injected into the reservoir 110 through the injection tube 150. After injection, the sealing cap 160 is tightened to ensure a seal. Then, the output end of the delivery tube 200 is inserted into the predetermined position in the patient's ureter. After preparation, the external controller is started, and the motor 350 starts working, driving the lead screw 340 to rotate. Through the principle of the lead screw and nut pair, the rectangular movable rod 330, which is threaded to the lead screw 340, converts the rotational motion into linear motion under the guidance and constraint of the rectangular horizontal tube 320. The rectangular movable rod 330 pushes the push rod 170 via the connecting rod 360, which in turn causes the piston 130 to move uniformly to the left within the reservoir 110, generating continuous and stable pressure on the mixture. Under pressure, the mixture flows through the porous diaphragm 400 inside the cap 120. The porous diaphragm 400, with its pore size of 50-200 micrometers, physically sieves and limits the speed of the microspheres, thereby achieving the slow-release output of the antibacterial microspheres, which enter the delivery tube 200 and finally reach the treatment site. During this process, a pressure sensor integrated into the inner wall of the cap 120 monitors the fluid pressure at the outlet in real time and feeds the data back to the controller. If the pressure rises abnormally, the controller can instruct the motor 350 to adjust its speed or pause to avoid safety risks caused by pipeline blockage. When treatment is completed or when medication needs to be replenished, the above steps can be reversed to disconnect the connection, clean, and refill.

[0043] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely preferred examples and are not intended to limit the utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claimed utility model. The scope of protection of this utility model is defined by the appended claims and their equivalents.

Claims

1. A ureteral delivery device adapted to release an antibacterial microsphere, comprising a delivery structure (100) and a delivery tube (200), characterized in that: The conveying structure (100) includes a liquid storage cylinder (110), a cylinder cover (120) is threaded to the left end of the liquid storage cylinder (110), a connecting end (121) is provided at the left end of the cylinder cover (120), a connecting sleeve (210) is provided at the input end of the conveying pipe (200) and threaded to the connecting end (121), a piston (130) for pushing antibacterial microspheres is provided inside the liquid storage cylinder (110), a push rod (170) is bolted to the right side of the piston (130), the right end of the push rod (170) passes through the inner wall of the liquid storage cylinder (110) to the outside, and a uniform speed driving structure (300) for driving the push rod (170) to move left and right is provided below the liquid storage cylinder (110).

2. The ureteral delivery device adapted to release antimicrobial microspheres according to claim 1, wherein: The cylinder cover (120) is provided with a porous diaphragm (400) with a pore size of 50-200 micrometers, and the inner wall of the cylinder cover (120) is also provided with a pressure sensor.

3. The ureteral delivery device adapted to release antimicrobial microspheres according to claim 2, wherein: The left end of the liquid storage cylinder (110) is bonded with a first sealing gasket (140), and the left side of the first sealing gasket (140) abuts against the right edge of the porous diaphragm (400).

4. The ureteral delivery device adapted for sustained release of antibacterial microspheres according to claim 1, characterized in that: A second sealing gasket (500) is bonded to the left end of the connecting end (121), and the second sealing gasket (500) fills the gap between the connecting end (121) and the connecting sleeve (210).

5. The ureteral delivery device adapted for sustained release of antibacterial microspheres according to claim 2, characterized in that: The outer wall of the liquid storage cylinder (110) and near the left end is provided with an injection pipe (150), the injection pipe (150) is threadedly connected to a sealing cap (160), and the injection pipe (150) is located to the right of the porous diaphragm (400).

6. The ureteral delivery device adapted for sustained release of antibacterial microspheres according to claim 1, characterized in that: The uniform speed drive structure (300) includes a mounting plate (310), and a rectangular horizontal tube (320) is bolted to the right side of the mounting plate (310). A rectangular movable rod (330) is movably connected inside the rectangular horizontal tube (320), and a connecting rod (360) is provided at the right end of the rectangular movable rod (330).

7. The ureteral delivery device adapted for sustained release of antibacterial microspheres according to claim 6, characterized in that: A rubber ring (180) is provided at the connection between the push rod (170) and the liquid storage cylinder (110), and the right end of the push rod (170) is connected to the connecting rod (360) by bolts.

8. The ureteral delivery device adapted for sustained release of antibacterial microspheres according to claim 7, characterized in that: A motor (350) is provided on the left side of the mounting plate (310). The output shaft of the motor (350) passes through the left side of the mounting plate (310) and is coaxially connected to a lead screw (340). The rectangular movable rod (330) is threaded to the outside of the lead screw (340).

9. The ureteral delivery device adapted for sustained release of antibacterial microspheres according to claim 6, characterized in that: The conveying structure (100) is provided with a U-shaped base (600) below it, and the mounting plate (310) is installed on the inner side of the U-shaped base (600) by bolts.

10. The ureteral delivery device adapted for sustained release of antibacterial microspheres according to claim 9, characterized in that: The top of the U-shaped base (600) is provided with two symmetrically arranged support inclined plates (610), and the liquid storage cylinder (110) is bonded between the two support inclined plates (610).

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