An antibacterial peptide chromatography column distributor

Abstract

This utility model relates to the field of pharmaceutical preparation technology and discloses an antimicrobial peptide chromatography column distributor, including a drug formulation reaction component. The drug formulation reaction component includes a chromatography column body, a positioning mechanism on the outside of the chromatography column body, a drug dispersion component for uniformly dispersing the antimicrobial peptide agent at the upper end of the chromatography column body, a placement component at the upper end of the chromatography column body, a support component on one side of the drug formulation reaction component, and a ball valve at the lower end of the drug formulation reaction component. The drug dispersion component uses a micro-pump to push the agent to be uniformly distributed in the chromatography column body, avoiding the generation of unevenness. The positioning mechanism and the support component provide stable support, ensuring that the positional accuracy of each component is not disturbed during operation. The ball valve precisely adjusts the agent outflow rate, ensuring the stability of the agent flow rate and avoiding the negative impact of uneven flow rate on the drug effect.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical preparation technology, specifically to an antimicrobial peptide chromatography column distributor. Background Technology

[0002] Antimicrobial peptide chromatography columns are experimental tools that utilize chromatography to separate and purify antimicrobial peptides. Antimicrobial peptides are small protein molecules widely distributed in organisms, possessing natural anti-infective capabilities against bacteria, fungi, and viruses. To study or apply these antimicrobial peptides, they first need to be separated and purified from complex biological samples. Antimicrobial peptide chromatography columns typically employ specific solid-phase materials and achieve separation of antimicrobial peptides by adjusting elution conditions. Common chromatography techniques include reversed-phase high-performance liquid chromatography (RP-HPLC), ion-exchange chromatography, and affinity chromatography. Affinity chromatography columns are specifically designed with binding sites for antimicrobial peptides to efficiently capture and separate them.

[0003] While existing antimicrobial peptide chromatography column technology can effectively separate and purify antimicrobial peptides, it has a significant drawback in drug production: it cannot uniformly disperse the purified antimicrobial peptides among other drugs. This problem often prevents the formation of stable mixtures during drug preparation, resulting in uneven distribution within the drug and affecting its efficacy. In practical applications, the poor dispersibility of antimicrobial peptides may lead to unstable drug formulation performance, or even precipitation or stratification during storage or use. This not only affects the bioavailability of the drug but may also reduce the therapeutic effect on patients. Therefore, a solution to these problems is urgently needed. Utility Model Content

[0004] The purpose of this invention is to provide an antimicrobial peptide chromatography column distributor to solve the problem mentioned in the background art that antimicrobial peptides cannot be uniformly dispersed in a specified reagent.

[0005] To achieve the above objectives, this utility model provides the following technical solution: an antimicrobial peptide chromatography column distributor, comprising a drug ratio reaction component, wherein the drug ratio reaction component comprises a chromatography column body, a positioning mechanism is provided on the outside of the chromatography column body, a drug solution dispersion component for uniformly dispersing the antimicrobial peptide agent is provided at the upper end of the chromatography column body, a placement component is provided at the upper end of the chromatography column body, a support component is provided on one side of the drug ratio reaction component, and a ball valve is provided at the lower end of the drug ratio reaction component;

[0006] The support assembly includes a support base, and a support rod is provided at one side of the upper center of the support base.

[0007] The positioning mechanism includes a movable sleeve that is slidably fitted on the outside of the support rod. An internally threaded tube is fixedly fitted on one side of the movable sleeve near the center. A first locking bolt is threaded inside the movable sleeve, and one end of the first locking bolt abuts against the outside of the support rod.

[0008] A connecting rod is fixedly connected to the center of the movable sleeve on the side away from the internal threaded tube. A support bar is fixedly connected to the end of the connecting rod away from the movable sleeve. Limit grooves are provided at both ends of the support bar near the center of the side close to the connecting rod.

[0009] The support bar has movable grooves extending through both ends on the side away from the connecting rod. Each of the two limiting grooves has a limiting piece slidably fitted inside it, and each of the two limiting pieces has an external threaded rod fixedly connected to its center on the side away from the connecting rod. The two external threaded rods are slidably fitted inside the two movable grooves.

[0010] Both external threaded rods are threaded with second locking bolts on their outer sides, and one side of each of the two second locking bolts abuts against the side of the support bar that is close to each other. Both external threaded rods are fixedly connected with clamps at the ends away from the limiting piece, and sponge pads are attached to the concave surfaces of both clamps. The chromatography column body is snapped into the two clamps and is in contact with the two sponge pads.

[0011] The drug formulation reaction assembly also includes a sleeve and a dropper. The sleeve is fixedly fitted to the upper center of the outer side of the chromatography column body, and the dropper is fixedly fitted to the lower center of the inner side of the chromatography column body. The inside of the chromatography column body contains a drug solution.

[0012] The placement assembly includes a placement cover, which is fitted inside the opening and is detachably installed. A semi-circular metal piece is fixedly fitted inside the upper center of the placement cover, and a buckle is fixedly fitted inside the center of the semi-circular metal piece on one side.

[0013] The drug dispersion assembly includes a micro pump, with a first infusion tube fixedly connected to the liquid input end of the micro pump and a second infusion tube fixedly connected to the liquid output end of the micro pump. The output end of the second infusion tube is fixedly connected to a porous quartz block, which is disposed inside the chromatography column body, and the second infusion tube is snapped into a buckle.

[0014] The ball valve is fixedly connected to the lower output end of the drip tube, and a beaker is placed at the center of the upper end of the support.

[0015] Compared with the prior art, the beneficial effects of this utility model are:

[0016] This invention relates to an antimicrobial peptide chromatography column distributor. The entire drug formulation reaction assembly, through the synergistic action of the chromatography column body, drug dispersion assembly, positioning mechanism, support assembly, and placement assembly, ensures the uniform dispersion and precise control of the antimicrobial peptide agent during the drug production process. The drug dispersion assembly uses a micro-pump to push the agent to be evenly distributed within the chromatography column body, avoiding the occurrence of unevenness.

[0017] The positioning mechanism and support components provide stable support, ensuring that the positional accuracy of each component is not disturbed during operation. The ball valve precisely regulates the drug flow rate, ensuring stable drug flow and avoiding the negative impact of uneven flow rate on drug efficacy. The placement component ensures the stable operation of the drug dispersion component, further improving the overall efficiency of the device. Through this integrated design, the problem of uneven dispersion of antimicrobial peptides during production can be effectively solved, ensuring the quality and stability of drug production and demonstrating significant drug production optimization effects. Attached Figure Description

[0018] Figure 1 This is a three-dimensional structural diagram of the support component of this utility model;

[0019] Figure 2 This is a three-dimensional structural schematic diagram of the support component of this utility model from another perspective;

[0020] Figure 3 This is a three-dimensional disassembled structural diagram of the positioning mechanism of this utility model;

[0021] Figure 4 This is a three-dimensional structural schematic diagram of the drug formulation reaction component of this utility model;

[0022] Figure 5 This is a three-dimensional disassembled structural diagram of the placement component of this utility model;

[0023] Figure 6 This is a three-dimensional structural diagram of the drug dispersion component of this utility model.

[0024] In the diagram: 1. Support assembly; 101. Support base; 102. Support rod; 2. Positioning mechanism; 201. Movable sleeve; 202. Internally threaded tube; 203. First locking bolt; 204. Connecting rod; 205. Limiting groove; 206. Movable groove; 207. Limiting piece; 208. Externally threaded rod; 209. Second locking bolt; 2010. Clamp; 2011. Sponge pad; 2012. Support strip; 3. Drug mixing reaction assembly; 301. Chromatography column body; 302. Sleeve opening; 303. Drop tube;

[0025] 304. Pharmaceutical solution; 4. Placement assembly; 401. Placement cover; 402. Semi-circular metal sheet;

[0026] 403, buckle; 5, drug dispersion assembly; 501, miniature pump; 502, first infusion tube; 503, second infusion tube; 504, porous quartz block; 6, ball valve; 7, beaker. Detailed Implementation

[0027] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0028] Please see Figure 1-6 This utility model provides an antimicrobial peptide chromatography column distributor, including a drug formulation reaction component 3, which includes a chromatography column body 301. The chromatography column body 301 serves as the core component, ensuring the uniform flow of the drug solution 304 within the system. A positioning mechanism 2 is provided on the outer side of the chromatography column body 301 for stably clamping the drug formulation reaction component 3. A drug dispersion component 5 is provided at the upper end of the chromatography column body 301 for uniformly dispersing the antimicrobial peptide drug. The drug dispersion component 5 delivers the drug into the chromatography column body 301 via a micro-pump 501. The upper end of the main body 301 is provided with a placement component 4 for installing the drug dispersion component 5. The side of the drug ratio reaction component 3 is provided with a support component 1 for supporting the positioning mechanism 2. The positioning mechanism 2 and the support component 1 provide stable support for the entire component, ensuring precise docking between the components during operation and avoiding the dispersion effect due to loosening or misalignment. The lower end of the drug ratio reaction component 3 is provided with a ball valve 6 for controlling the flow rate of the drug when it flows out of the chromatography column main body 301. The support component 1 includes a support base 101, and a support rod 102 is provided on one side of the upper center of the support base 101.

[0029] Positioning mechanism 2 includes a movable sleeve 201, which is slidably sleeved on the outside of support rod 102. Positioning mechanism 2, through the slidable connection between movable sleeve 201 and support rod 102, can adjust the clamping position of chromatography column body 301 as needed. An internally threaded tube 202 is fixedly sleeved on one side of the movable sleeve 201 near its center. A first locking bolt 203 is threaded inside the movable sleeve 201. When the first locking bolt 203 is tightened, the movable sleeve 201 will be fixed on the outside of support rod 102, ensuring the clamping position of chromatography column body 301. 01. Stability during operation: One end of the first locking bolt 203 abuts against the outside of the support rod 102. A connecting rod 204 is fixedly connected to the center of the movable sleeve 201 away from the internal threaded tube 202. A support bar 2012 is fixedly connected to the end of the connecting rod 204 away from the movable sleeve 201. Limiting grooves 205 are opened at both ends of the support bar 2012 near the center of the side close to the connecting rod 204. Movable grooves 206 are opened through the support bar 2012 at both ends of the side away from the connecting rod 204. The two limiting grooves Both 205 are fitted with slidable limiting plates 207, and each limiting plate 207 is fixedly connected to an external threaded rod 208 at the center of the side away from the connecting rod 204. The limiting plates 207 and the external threaded rods 208 slide through the movable grooves 206 to ensure precise control of the distance between the limiting plates 207 and the support bar 2012. The two external threaded rods 208 are slidably fitted inside the two movable grooves 206, and each of the two external threaded rods 208 is threaded with a second locking bolt 209 on its outer side. The two external threaded rods 208 are fixedly connected to the ends of the two external threaded rods 208 away from the limiting piece 207 with clamps 2010, and the concave surfaces of the two clamps 2010 are covered with sponge pads 2011. The clamps 2010 and sponge pads 2011 further provide a stable clamping of the chromatography column body 301, preventing the column from shifting during operation and ensuring the stability of reagent flow. The chromatography column body 301 is clamped inside the two clamps 2010 and fits against the two sponge pads 2011.

[0030] The drug formulation reaction assembly 3 also includes a sleeve 302 and a dropper 303. The sleeve 302 is fixedly sleeved on the upper part of the outer center of the chromatography column body 301, and the dropper 303 is fixedly sleeved on the lower part of the inner center of the chromatography column body 301. The inside of the chromatography column body 301 contains a drug solution 304.

[0031] The placement component 4 includes a placement cover 401, which is fitted inside the sleeve opening 302. The placement cover 401 and the sleeve opening 302 are detachably installed. A semi-circular metal piece 402 is fixedly fitted at the upper center of the placement cover 401, and a buckle 403 is fixedly fitted at one side of the center of the semi-circular metal piece 402.

[0032] The drug dispersion assembly 5 includes a micro-pump 501, with a first infusion tube 502 fixedly connected to the liquid inlet end of the micro-pump 501. The drug is delivered to the chromatography column body 301 through the first infusion tube 502 via the micro-pump 501. A second infusion tube 503 is fixedly connected to the liquid outlet end of the micro-pump 501. The drug is dispersed into the porous quartz block 504 through the second infusion tube 503. The outlet end of the second infusion tube 503 is fixedly connected to... A porous quartz block 504 is attached. The porous structure of the quartz block helps the drug solution to diffuse evenly within the chromatography column body 301. The porous quartz block 504 can effectively improve the uniformity of drug distribution within the column. The porous quartz block 504 is located inside the chromatography column body 301, and the second infusion tube 503 is snapped into the buckle 403. The ball valve 6 is fixedly connected to the lower output end of the drip tube 303, and a beaker 7 is placed at the center of the upper end of the support base 101.

[0033] Working principle: The drug formulation reaction component 3 ensures the dispersion and control of the antimicrobial peptide agent during the drug preparation process through the precise synergistic action of its various components. The chromatography column body 301, as the core component, ensures the uniform flow of the drug solution 304 within the system. The drug dispersion component 5 delivers the drug into the chromatography column body 301 through a micro-pump 501, thereby ensuring uniform dispersion of the drug. The ball valve 6 is used to precisely control the flow rate of the drug, ensuring a stable flow rate during dispersion and avoiding uneven drug distribution, thus ensuring the stability and consistency of drug efficacy. The positioning mechanism 2 and the support component 1 provide stable support for the entire component, ensuring precise alignment between the components during operation and preventing the dispersion effect from being affected by loosening or misalignment.

[0034] The positioning mechanism 2 is slidably connected to the support rod 102 via the movable sleeve 201, which can adjust the clamping position of the chromatography column body 301 as needed. When the first locking bolt 203 is tightened, the movable sleeve 201 will be fixed to the outside of the support rod 102, ensuring the stability of the chromatography column body 301 during operation. The limiting piece 207 and the external threaded rod 208 slide through the movable groove 206, ensuring that the distance between the limiting piece 207 and the support bar 2012 is precisely controlled. The clamp 2010 and the sponge pad 2011 further provide a stable clamping of the chromatography column body 301, preventing the column from shifting during operation and ensuring the stability of the reagent flow.

[0035] The drug dispersion component 5 delivers the drug to the chromatography column body 301 through the first infusion tube 502 via the micro pump 501. The drug is then dispersed into the porous quartz block 504 through the second infusion tube 503. The porous structure of the quartz block helps the drug to diffuse evenly within the chromatography column body 301. The porous quartz block 504 can effectively improve the uniformity of drug distribution within the column, thereby ensuring the uniform dispersion of the antimicrobial peptide and avoiding reduced efficacy due to drug aggregation or uneven distribution.

[0036] The placement assembly 4 uses the placement cover 401 to fix the components inside the sleeve 302 in the appropriate position. The placement cover 401 and the sleeve 302 are detachable, which can be easily maintained or replaced. The semi-circular metal piece 402 is fixed inside the placement cover 401 and plays a supporting role for the connector. At the same time, the buckle 403 ensures that the connection between the second infusion tube 503 and the clamp 2010 is stable and reliable. Through this design, the placement assembly 4 ensures that the drug dispersion assembly 5 can work stably throughout the entire drug preparation process.

[0037] The support assembly 1 includes a support base 101, which provides stable support for the drug formulation reaction assembly 3. The beaker 7 at the center of the upper end of the support base 101 is used to receive the drug solution 304 dispersed by the chromatography column body 301, ensuring the collection and subsequent use of the drug. The ball valve 6 controls the outflow of the drug, ensuring that the flow rate of the drug is moderate when it flows out. Through the precise adjustment of the ball valve 6, the flow rate of the drug can be finely controlled to avoid excessive drug or unstable flow rate, which would affect the uniformity of drug efficacy and the stability of the drug production process.

[0038] It will be apparent to those skilled in the art that this invention is not limited to the details of the exemplary embodiments described above, and that it can be implemented in other specific forms without departing from the spirit or essential characteristics of this invention. Therefore, the embodiments should be considered illustrative and non-limiting in all respects, and the scope of this invention is defined by the appended claims rather than the foregoing description. Thus, it is intended that all variations falling within the meaning and scope of equivalents of the claims be included within this invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

Claims

1. An antibacterial peptide chromatography column distributor comprising a drug ratio reaction assembly (3), characterized in that: The drug formulation reaction assembly (3) includes a chromatography column body (301), a positioning mechanism (2) is provided on the outside of the chromatography column body (301), a drug dispersion assembly (5) for uniformly dispersing antimicrobial peptides is provided at the upper end of the chromatography column body (301), a placement assembly (4) is provided at the upper end of the chromatography column body (301), a support assembly (1) is provided on one side of the drug formulation reaction assembly (3), and a ball valve (6) is provided at the lower end of the drug formulation reaction assembly (3). The support assembly (1) includes a support base (101), and a support rod (102) is provided on one side of the upper center of the support base (101).

2. The antibacterial peptide chromatography column sparger of claim 1, wherein: The positioning mechanism (2) includes a movable sleeve (201), which is slidably sleeved on the outside of the support rod (102). An internally threaded tube (202) is fixedly sleeved on one side of the movable sleeve (201) near the center. A first locking bolt (203) is threaded inside the movable sleeve (201), and one end of the first locking bolt (203) abuts against the outside of the support rod (102).

3. The antibacterial peptide chromatography column sparger of claim 2, wherein: A connecting rod (204) is fixedly connected to the center of the movable sleeve (201) away from the internal threaded tube (202). A support bar (2012) is fixedly connected to the end of the connecting rod (204) away from the movable sleeve (201). Limiting grooves (205) are provided at both ends of the support bar (2012) near the center of the side close to the connecting rod (204).

4. The anti-microbial peptide chromatography column sparger of claim 3, wherein: The support bar (2012) has movable grooves (206) extending through both ends on the side away from the connecting rod (204). The two limiting grooves (205) are each fitted with a limiting piece (207). The center of the two limiting pieces (207) away from the connecting rod (204) is fixedly connected with an external thread rod (208). The two external thread rods (208) are slidably fitted inside the two movable grooves (206).

5. The antibacterial peptide chromatography column sparger of claim 4, wherein: Both external threaded rods (208) are threaded with second locking bolts (209) on their outer sides, and the two second locking bolts (209) abut against each other on one side of the support bar (2012). Both external threaded rods (208) are fixedly connected with clamps (2010) at the ends away from the limiting piece (207), and sponge pads (2011) are attached to the concave surfaces of both clamps (2010). The chromatography column body (301) is snapped into the two clamps (2010) and fits against the two sponge pads (2011).

6. The antibacterial peptide chromatography column sparger of claim 1, wherein: The drug formulation reaction assembly (3) further includes a sleeve (302) and a dropper (303). The sleeve (302) is fixedly fitted to the upper center of the outer side of the chromatography column body (301), and the dropper (303) is fixedly fitted to the lower center of the inner side of the chromatography column body (301). The inside of the chromatography column body (301) contains a drug solution (304).

7. The antibacterial peptide chromatography column sparger of claim 6, wherein: The placement component (4) includes a placement cover (401), which is fitted inside the opening (302). The placement cover (401) and the opening (302) are detachably installed. A semi-circular metal piece (402) is fixedly fitted at the upper center of the placement cover (401), and a buckle (403) is fixedly fitted at one side of the center of the semi-circular metal piece (402).

8. The anti-microbial peptide chromatography column sparger of claim 7, wherein: The drug dispersion assembly (5) includes a micro pump (501), the liquid input end of which is fixedly connected to a first infusion tube (502), the liquid output end of which is fixedly connected to a second infusion tube (503), and the output end of the second infusion tube (503) is fixedly connected to a porous quartz block (504), which is disposed inside the chromatography column body (301), and the second infusion tube (503) is snapped into the buckle (403).

9. The anti-microbial peptide chromatography column sparger of claim 6, wherein: The ball valve (6) is fixedly connected to the lower output end of the drip tube (303), and a beaker (7) is placed at the center of the upper end of the support base (101).

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