A device for fluorescent detection of oligonucleotide drugs

Abstract

The utility model discloses an oligonucleotide drug fluorescence detection dropwise adding device, including support frame, the lower extreme fixedly connected with fixed base of support frame right side, the quantity of fixed base is four, the upper end of fixed base right side and the top of support frame place has the displacement gun, and the lower extreme both sides of fixed base outer surface all are fixedly connected with the connecting plate. The utility model discloses the setting of displacement gun, facilitates personnel to drop in the process of oligonucleotide drug fluorescence detection and adds the operation of job, through the setting of support frame and fixed base, can support displacement gun after dropwise adding operation is completed to through the setting of screw rod, movable frame, connecting rod, protective cover, pivot, connecting plate and fixed base, and the effective protection of the periphery of the gun head connecting place on displacement gun is carried out in the process of placing to personnel, avoids dust impurity and enters the inside of displacement gun, and the precision of subsequent oligonucleotide drug fluorescence detection dropwise adding operation is ensured.

Description

Technical Field

[0001] This utility model relates to the field of biological detection technology, specifically to an oligonucleotide drug fluorescence detection dripping device. Background Technology

[0002] In the research, development, production, and quality testing of oligonucleotide drugs, fluorescence detection is a commonly used and important analytical method. By using fluorescent labels to specifically bind to oligonucleotide drugs, the intensity and characteristics of the fluorescence signal are used to analyze information such as drug concentration, purity, structure, and interactions with other biomolecules.

[0003] Currently, in the process of oligonucleotide drug fluorescence detection experiments, pipettes are usually used for drop addition. However, after the traditional pipette is dropped, the disposable tip often needs to be removed. During the placement of the pipette, the lack of a protective structure around the tip connection allows dust and impurities from the environment to easily enter the pipette, affecting the accuracy of subsequent oligonucleotide drug fluorescence detection drop addition operations, thus failing to meet the needs of users. Utility Model Content

[0004] The purpose of this invention is to provide an oligonucleotide drug fluorescence detection and dispensing device, which has the advantage of protecting the area around the pipette tip during pipette placement to prevent dust or foreign objects from entering the inside of the pipette tip and ensuring the accuracy of subsequent dispensing operations.

[0005] To achieve the above objectives, this utility model provides the following technical solution: an oligonucleotide drug fluorescence detection dispensing device, comprising a support frame, a fixed base fixedly connected to the lower right end of the support frame, the number of fixed bases being four, a pipette placed between the upper right end of the fixed base and the top of the support frame, connecting plates fixedly connected to the lower ends of both sides of the outer surface of the fixed base, a rotating shaft movably inserted through the right end of the connecting plate, a protective cover fixedly connected between the surfaces of two rotating shafts, connecting rods movably connected to both sides of the outer surface of the protective cover via pins, a movable frame movably connected between the left ends of the eight connecting rods via pins, and a screw threadedly connected to the middle end of the movable frame.

[0006] As a preferred embodiment, a first rubber pad is fixedly installed on the right side of the mounting base, the upper end of the first rubber pad is in contact with the lower end of the pipette, and a second rubber pad is fixedly installed on the left side of the protective cover.

[0007] As a preferred embodiment, a base plate is fixedly connected to the bottom of the support frame, and rubber anti-slip pads are fixedly connected to both ends of the bottom of the base plate. A reinforcing plate is fixedly connected between the top of the base plate and the lower left end of the support frame.

[0008] As a preferred embodiment, both ends of the movable frame are slidably connected to guide rods, and the right side of the guide rods is fixedly connected to the left side of the support frame.

[0009] As a preferred embodiment, a fixing plate is fixedly connected to the upper end of the left side of the support frame, and the upper end of the screw is movably connected to the surface of the fixing plate through a bearing.

[0010] As a preferred embodiment, a turntable is fixedly connected to the top of the screw, and anti-slip protrusions are fixedly connected to the surface of the turntable.

[0011] As a preferred embodiment, a support plate is fixedly connected to the upper right side of the support frame, and the upper end of the pipette is placed on the right side of the support plate.

[0012] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0013] This invention, through the design of the pipette, facilitates the addition of liquid during the fluorescence detection of oligonucleotide drugs. The support frame and fixed base provide support after the addition is complete. Furthermore, the screw, movable frame, connecting rod, protective cap, rotating shaft, connecting plate, and fixed base effectively protect the area around the pipette tip connection point during placement, preventing dust and impurities from adhering to and entering the pipette, thus ensuring the accuracy of subsequent oligonucleotide drug fluorescence detection addition. Attached Figure Description

[0014] Figure 1 This is a perspective view of the present utility model;

[0015] Figure 2 This is a schematic diagram of the left side structure of this utility model;

[0016] Figure 3 This is a schematic diagram of the protective cover structure of this utility model;

[0017] Figure 4 This utility model Figure 1 A magnified view of section A in the image.

[0018] In the diagram: 1. Pipette; 2. Support frame; 3. Support plate; 4. First rubber pad; 5. Reinforcing plate; 6. Base plate; 7. Protective cover; 8. Fixing seat; 9. Turntable; 10. Fixing plate; 11. Screw; 12. Moving frame; 13. Rubber anti-slip pad; 14. Guide slide rod; 15. Connecting rod; 16. Second rubber pad; 17. Connecting plate; 18. Rotating shaft. Detailed Implementation

[0019] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0020] Secondly, the term "an embodiment" or "embodiment" as used herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of the present invention. The phrase "in one embodiment" appearing in different places in this specification does not necessarily refer to the same embodiment, nor is it a single or selective embodiment that excludes other embodiments.

[0021] The components of this application, such as pipette 1, support frame 2, support plate 3, first rubber pad 4, reinforcing plate 5, base plate 6, protective cover 7, fixed seat 8, turntable 9, fixed plate 10, screw 11, movable frame 12, rubber anti-slip pad 13, guide slide rod 14, connecting rod 15, second rubber pad 16, connecting plate 17, and rotating shaft 18, are all general standard parts or parts known to those skilled in the art. Their structure and principle can be learned by those skilled in the art through technical manuals or conventional experimental methods.

[0022] Example 1:

[0023] Please see Figures 1-4 As shown, this utility model provides an oligonucleotide drug fluorescence detection dripping device, including a support frame 2. A fixed seat 8 is fixedly connected to the lower right end of the support frame 2. There are four fixed seats 8. A pipette 1 is placed between the upper right end of the fixed seat 8 and the top of the support frame 2. A connecting plate 17 is fixedly connected to the lower ends of both sides of the outer surface of the fixed seat 8. A rotating shaft 18 is movably inserted through the right end of the connecting plate 17. A protective cover 7 is fixedly connected between the surfaces of the two rotating shafts 18. A connecting rod 15 is movably connected to both sides of the outer surface of the protective cover 7 through a pin. A movable frame 12 is movably connected between the left ends of the eight connecting rods 15 through a pin. A screw 11 is threadedly connected to the middle end of the movable frame 12.

[0024] In this technical solution, after the oligonucleotide drug fluorescence detection dispensing operation is completed, the pipette 1 is placed between the support frame 2 and the fixed seat 8, and the screw 11 is rotated to drive the moving frame 12 to move upward. While the moving frame 12 is moving, it can pull the protective cover 7 and the rotating shaft 18 through the connecting rod 15 to rotate along the through hole of the connecting plate 17 until the protective cover 7 can be tightly attached to the right side of the fixed seat 8 under the action of rotation. Thus, under the cooperation between the fixed seat 8 and the protective cover 7, the area around the pipette tip connection of the pipette 1 can be effectively protected, preventing dust and impurities from adhering and entering the interior of the pipette 1, thereby ensuring the accuracy of the subsequent oligonucleotide drug fluorescence detection dispensing operation.

[0025] Example 2:

[0026] Based on Embodiment 1, this utility model is as follows: Figures 1-4 As shown, a first rubber pad 4 is fixedly installed on the right side of the fixed base 8, and the upper end of the first rubber pad 4 contacts the lower end of the pipette 1. A second rubber pad 16 is fixedly installed on the left side of the protective cover 7. A base plate 6 is fixedly connected to the bottom of the support frame 2. Rubber anti-slip pads 13 are fixedly connected to both ends of the bottom of the base plate 6. A reinforcing plate 5 is fixedly connected between the top of the base plate 6 and the lower end of the left side of the support frame 2. Guide slide rods 14 are slidably connected to both ends of the movable frame 12. The right side of the guide slide rod 14 is fixedly connected to the left side of the support frame 2. A fixed plate 10 is fixedly connected to the upper end of the left side of the support frame 2. The upper end of the screw 11 is movably connected to the surface of the fixed plate 10 through a bearing. A turntable 9 is fixedly connected to the top of the screw 11. Anti-slip protrusions are fixedly connected to the surface of the turntable 9. A support plate 3 is fixedly connected to the upper right side of the support frame 2. The upper end of the pipette 1 is placed on the right side of the support plate 3.

[0027] In this technical solution, the sealing effect between the protective cover 7 and the fixed seat 8 during the closing process is effectively improved by setting the first rubber pad 4 and the second rubber pad 16. The anti-slip pad 13 effectively improves the protection effect between the base plate 6 and the tabletop. The reinforcing plate 5 effectively improves the connection strength between the base plate 6 and the support frame 2. The guide slide rod 14 guides the movable frame 12 and prevents it from tilting during movement. The fixed plate 10 supports the upper end of the screw 11. The turntable 9 facilitates the operation of the screw 11 for rotation. The support plate 3 supports the upper end of the pipette 1.

[0028] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this utility model, and are not intended to limit the scope of protection of this utility model. Although this utility model has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of this utility model without departing from the essence and scope of the technical solutions of this utility model.

Claims

1. An oligonucleotide drug fluorescence detection dispensing device, comprising a support frame (2), characterized in that: A fixed seat (8) is fixedly connected to the lower right side of the support frame (2). There are four fixed seats (8). A pipette (1) is placed between the upper right side of the fixed seat (8) and the top of the support frame (2). A connecting plate (17) is fixedly connected to the lower ends of both sides of the outer surface of the fixed seat (8). A rotating shaft (18) is movably inserted through the right end of the connecting plate (17). A protective cover (7) is fixedly connected between the surfaces of the two rotating shafts (18). A connecting rod (15) is movably connected to both sides of the outer surface of the protective cover (7) through a pin. A movable frame (12) is movably connected between the left ends of the eight connecting rods (15) through a pin. A screw (11) is threadedly connected to the middle end of the movable frame (12).

2. The oligonucleotide drug fluorescence detection and dispensing device according to claim 1, characterized in that: A first rubber pad (4) is fixedly installed on the right side of the fixed base (8), and the upper end of the first rubber pad (4) contacts the lower end of the pipette (1). A second rubber pad (16) is fixedly installed on the left side of the protective cover (7).

3. The oligonucleotide drug fluorescence detection and dispensing device according to claim 1, characterized in that: The bottom of the support frame (2) is fixedly connected to a base plate (6), and rubber anti-slip pads (13) are fixedly connected to both ends of the bottom of the base plate (6). A reinforcing plate (5) is fixedly connected between the top of the base plate (6) and the lower left side of the support frame (2).

4. The oligonucleotide drug fluorescence detection and dispensing device according to claim 1, characterized in that: Both ends of the movable frame (12) are slidably connected to guide slide rods (14), and the right side of the guide slide rods (14) is fixedly connected to the left side of the support frame (2).

5. The oligonucleotide drug fluorescence detection and dispensing device according to claim 1, characterized in that: A fixing plate (10) is fixedly connected to the upper left side of the support frame (2), and the upper end of the screw (11) is movably connected to the surface of the fixing plate (10) through a bearing.

6. The oligonucleotide drug fluorescence detection and dispensing device according to claim 1, characterized in that: The top of the screw (11) is fixedly connected to a turntable (9), and the surface of the turntable (9) is fixedly connected to anti-slip protrusions.

7. The oligonucleotide drug fluorescence detection and dispensing device according to claim 1, characterized in that: The upper right end of the support frame (2) is fixedly connected to a support plate (3), and the upper end of the pipette (1) is placed on the right side of the support plate (3).

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