Liquid suction gun with anti-blockage

Abstract

The utility model relates to a kind of liquid suction gun of preventing blockage, including gun head, the tip of gun head has main suction port, main suction port transversely is provided with first strip through slot, and the both ends of first strip through slot are auxiliary suction port. First strip through slot forms inward recess structure at main suction port, and the both ends of first strip through slot form auxiliary suction port, when using liquid suction gun to carry out pipetting operation, liquid can enter into liquid suction gun by 3 directions in normal liquid suction process of liquid suction gun, respectively, the lower side of main suction port and the two auxiliary suction ports on the both sides of main suction port, if block exists in centrifugal tube, block can only be blocked on one of suction port, if multiple blockage occurs, because there are 3 liquid suction directions, liquid can flow from the gap of multiple block, solve the problem of complete blockage of suction port, with the advantage that liquid taking efficiency is higher.

Description

Technical Field

[0001] This utility model relates to the field of analytical testing technology, and in particular to a liquid suction gun that prevents blockage by lumps. Background Technology

[0002] In biological experiments, samples in centrifuge tubes often clump together due to various factors, leading to difficulties in pipetting and even clogging of pipette tips, thus affecting experimental efficiency and automated processes. The formation mechanisms of these clumps mainly include cell aggregation, protein precipitation, and aggregation of biomolecular complexes.

[0003] Cell aggregation is a common problem. During centrifugation after cell culture, cells may clump together due to physical aggregation or the influence of the culture environment (such as pH changes or the action of cell adhesion molecules). These aggregates deposit at the bottom of the tube, hindering pipetting operations, and have a significant impact, especially in delicate experiments such as the preparation of single-cell suspensions.

[0004] Protein precipitation can also lead to the formation of clumps. High concentrations of protein may precipitate during centrifugation due to pH approaching the isoelectric point or changes in salt concentration. For example, adjusting the pH to the isoelectric point during protein purification weakens charge repulsion, leading to aggregation; salting out (such as ammonium sulfate precipitation) reduces solubility, forming a dense precipitate. These precipitates easily adhere to the tube walls or pipette tip inlet, causing blockage.

[0005] Furthermore, biomolecular complexes (such as antibody-antigen complexes or nucleic acid-protein complexes) may form insoluble clumps after centrifugation in experiments such as immunoprecipitation (IP) and chromatin co-precipitation (ChIP). These aggregates have a compact structure and are difficult to disperse using routine pipetting techniques, further increasing the risk of pipette tip clogging.

[0006] Currently, this problem mainly relies on manual intervention (such as repeated pipetting or changing pipette tips), but this introduces errors and reduces throughput. Therefore, developing techniques to optimize centrifugation conditions, improve pipette tip design, or introduce pretreatment methods is of great significance for improving experimental stability and automation compatibility. Summary of the Invention

[0007] To address the aforementioned technical problems, this utility model provides a liquid suction gun that prevents blockage by lumps. The gun head is horizontally through-hole, allowing liquid to be drawn from both sides in addition to the tip, resulting in higher liquid drawing efficiency.

[0008] To achieve the above objectives, the present invention adopts the following technical solution:

[0009] A suction gun designed to prevent blockage by lumps, comprising:

[0010] The nozzle has a main suction port at its tip, and a first strip-shaped groove is provided horizontally through the main suction port. The two ends of the first strip-shaped groove are auxiliary suction ports.

[0011] In one possible implementation, the main suction port is provided with a second strip-shaped channel, which is arranged to intersect with the first strip-shaped channel.

[0012] In one possible implementation, the second strip-shaped through groove is arranged perpendicularly to the first strip-shaped through groove.

[0013] In one possible implementation, the depth of the first strip groove is 2 mm.

[0014] In one possible implementation, the depth of the first strip groove is 4 mm.

[0015] In one possible implementation, the depth of the first strip groove is 6 mm.

[0016] This utility model has the following advantages due to the adoption of the above technical solution:

[0017] The first strip-shaped channel forms an inwardly recessed structure at the main suction port. At both ends of the first strip-shaped channel, auxiliary suction ports are formed. When using a suction gun for liquid transfer, during normal suction, the liquid can enter the suction gun from three directions: directly below the main suction port, and the two auxiliary suction ports on both sides of the main suction port. If there are lumps in the centrifuge tube, the lumps can only block one of the suction ports. If multiple lumps block the port, the liquid can flow through the gaps between the lumps because there are three suction directions, which solves the problem of complete blockage of the suction port and has the advantage of high liquid collection efficiency. Attached Figure Description

[0018] Figure 1 This is a diagram showing the usage state of the suction gun in one embodiment of this utility model;

[0019] Figure 2 This is a schematic diagram of the specific structure of the suction gun in one embodiment of the present invention;

[0020] Figure 3 This is a schematic diagram of the specific structure of the gun head in one embodiment of the present invention;

[0021] Figure label:

[0022] 1. Pipe tip; 2. Main suction port; 3. First strip groove; 4. Secondary suction port; 5. Second strip groove; 6. Centrifuge tube. Detailed Implementation

[0023] To make the objectives, technical solutions, and advantages of this utility model clearer, the technical solutions of this utility model are described clearly and completely below. Obviously, the described embodiments are only some embodiments of this utility model, not all embodiments. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of this utility model.

[0024] Unless otherwise defined, the technical or scientific terms used in this invention shall have the ordinary meaning understood by one of ordinary skill in the art to which this invention pertains. The terms "first," "second," "third," "fourth," and similar words used in this invention do not indicate any order, quantity, or importance, but are merely used to distinguish different components. Terms such as "comprising" or "including" mean that the element or object preceding the word encompasses the elements or objects listed following the word and their equivalents, without excluding other elements or objects. Terms such as "connected" or "linked" are not limited to physical or mechanical connections, but can include electrical connections, whether direct or indirect.

[0025] In biological experiments, samples in centrifuge tubes often clump together due to various factors, leading to difficulties in pipetting and even clogging of pipette tips, affecting experimental efficiency and automated processes. The formation mechanisms of these clumps mainly include cell aggregation, protein precipitation, and aggregation of biomolecular complexes. The clumps are densely packed and difficult to disperse using conventional pipetting techniques, posing a risk of tip clogging. Currently, this problem mainly relies on manual intervention (such as repeated pipetting or tip replacement), but this introduces errors and reduces throughput. To address these technical problems, this invention provides a pipette designed to prevent clump clogging. The pipette tip is horizontally designed, allowing liquid to be taken from both sides in addition to the tip, resulting in higher liquid collection efficiency. The technical solution of this invention will be described in detail below with specific examples.

[0026] Reference Figure 1 , Figure 2 as well as Figure 3 As shown, the present invention relates to a liquid suction gun for preventing blockage by lumps, including a gun head 1, the tip of the gun head 1 having a main suction port 2, the main suction port 2 having a first strip-shaped through groove 3 extending laterally, and the two ends of the first strip-shaped through groove 3 being auxiliary suction ports 4.

[0027] For example, the first strip-shaped channel 3 forms an inwardly recessed structure at the main suction port 2, and the two ends of the first strip-shaped channel 3 form auxiliary suction ports 4. When using the suction gun for liquid transfer, during normal liquid suction, the liquid can enter the suction gun from three directions: directly below the main suction port 2, and the two auxiliary suction ports 4 on both sides of the main suction port 2. If there are lumps in the centrifuge tube 6, the lumps can only block one of the suction ports. If multiple lumps block the port, the liquid can flow through the gaps between the multiple lumps because there are three suction directions, which solves the problem of complete blockage of the suction port and has the advantage of high liquid collection efficiency.

[0028] In one embodiment, more preferably, the main suction port 2 is provided with a second strip groove 5, which is arranged to intersect with the first strip groove 3.

[0029] In this embodiment, the second strip groove 5 is specifically arranged perpendicularly to the first strip groove 3.

[0030] It should be noted that the first strip groove 3 and the second strip groove 5 are combined to form a cross-shaped groove at the main suction port 2, which allows the tip of the suction gun to have more suction directions and further optimizes the suction stability of the suction gun.

[0031] The suction gun can be designed in multiple sizes, specifically, suction guns with depths of 2, 4 and 6 mm for the first strip groove 3.

[0032] For example, in actual operation, the operator can select the appropriate size of the aspirator according to the specific situation of the block in the centrifuge tube 6. When the block volume is small, a shallower aspirator is selected, and when the block is large, a deeper aspirator is selected. The use of this adaptability can also optimize the aspirator's aspiration stability.

[0033] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this utility model, and not to limit it. Although this utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of this utility model.

Claims

1. A liquid suction gun designed to prevent blockage by lumps, characterized in that, include: The nozzle has a main suction port at its tip, and a first strip-shaped groove is provided horizontally through the main suction port. The two ends of the first strip-shaped groove are auxiliary suction ports.

2. The liquid suction gun according to claim 1, characterized in that, The main suction port is provided with a second strip-shaped channel, which is arranged to intersect with the first strip-shaped channel.

3. The liquid suction gun according to claim 2, characterized in that, The second strip-shaped through groove is perpendicular to the first strip-shaped through groove.

4. The liquid suction gun according to claim 1, characterized in that, The depth of the first strip groove is 2 mm.

5. The liquid suction gun according to claim 1, characterized in that, The depth of the first strip groove is 4 mm.

6. The liquid suction gun according to claim 1, characterized in that, The depth of the first strip groove is 6 mm.

Images