A rapid detection device for release rate of trazodone hydrochloride sustained-release tablets

Abstract

The utility model discloses a kind of trazodone hydrochloride sustained-release tablets release rate rapid detection equipment, it is related to pharmaceutical detection technical field, including installation box, the installation box outside is fixedly connected with observation window, the installation box inside is fixedly connected with baffle, the installation box inside is provided with two detection barrels, the detection barrel top is provided with cover plate, the cover plate top is fixedly connected with handle, the cover plate top is provided with notched, the installation box top is provided with automatic sampling mechanism, and one of the detection barrel bottom is provided with analog motion mechanism. The utility model discloses a kind of trazodone hydrochloride sustained-release tablets release rate rapid detection equipment, by the design of analog motion mechanism, the motion state of sustained-release tablets in human body is simulated, so that detection result is more close to actual situation, and the reliability of detection is improved.

Description

Technical Field

[0001] This utility model relates to the field of drug detection technology, and in particular to a rapid detection device for the release rate of trazodone hydrochloride sustained-release tablets. Background Technology

[0002] Trazodone hydrochloride extended-release tablets are a second-generation antidepressant, belonging to the class of 5-hydroxytryptamine (5-HT) receptor antagonists and 5-HT reuptake inhibitors (SARIs). The rapid release rate detection device for trazodone hydrochloride extended-release tablets is a device specifically designed to detect the drug release rate of trazodone hydrochloride extended-release tablets under specific conditions.

[0003] The existing technology has the following problems:

[0004] Existing detection devices cannot accurately simulate the impact of human movement on drug release, resulting in discrepancies between the test results and actual drug administration scenarios. Utility Model Content

[0005] This invention provides a rapid detection device for the release rate of trazodone hydrochloride sustained-release tablets, in order to solve the problem mentioned in the background art that the simulated environment is too simple, resulting in deviations between the detection results and the actual usage scenario.

[0006] To solve the above-mentioned technical problems, the technical solution adopted by this utility model is as follows:

[0007] A rapid detection device for the release rate of trazodone hydrochloride sustained-release tablets includes a mounting box. An observation window is fixedly connected to the outside of the mounting box, and a partition is fixedly connected to the inside of the mounting box. Two detection barrels are arranged inside the mounting box, and a cover plate is provided on the top of the detection barrel. A handle is fixedly connected to the top of the cover plate, and a slot is opened on the top of the cover plate. An automatic sampling mechanism is provided on the top of the mounting box, and a simulated motion mechanism is provided at the bottom of one of the detection barrels.

[0008] The automatic sampling mechanism includes a mounting frame, which is fixedly connected to the top of the mounting box on the outside. An electric push rod is fixedly connected to the top of the mounting frame. A mounting plate is fixedly connected to the output end of the electric push rod. Two suction cylinders are fixedly connected to the bottom of the mounting plate. A suction tube is fixedly connected to the bottom of each suction cylinder. A piston block is slidably connected inside each suction cylinder. A connecting rod is fixedly connected to the top of the piston block. A fixing block is fixedly connected to the top of the connecting rod.

[0009] The simulated motion mechanism includes a fixed ring and a motor. The inner side of the fixed ring is fixedly connected to the outer periphery of the detection barrel. A gear is fixedly connected to the outer periphery of one end of the fixed ring. The outer side of the motor is fixedly connected to the outer side of the mounting box. A rotating shaft is fixedly connected to the output end of the motor. A connecting block is fixedly connected to the outer side of the rotating shaft. A toothed block is fixedly connected to the outer side of the connecting block.

[0010] Preferably, the outer periphery of the connecting rod is slidably connected to the inside of the mounting plate, and the outer periphery of the connecting rod is slidably connected to the inside of the mounting bracket.

[0011] Preferably, the fixing block and the top of the mounting bracket abut against each other.

[0012] Preferably, the outer periphery of the straw is slidably connected to the inside of the groove.

[0013] Preferably, the outer circumference of the fixing ring is rotatably connected to the inside of the partition, and the outer circumference of the fixing ring is rotatably connected to the inside of the mounting box.

[0014] Preferably, the tooth block and the gear mesh with each other.

[0015] Preferably, the cover plate and the detection barrel are snapped together.

[0016] Compared with the prior art, the present invention has the following beneficial effects:

[0017] 1. This utility model provides a rapid detection device for the release rate of trazodone hydrochloride sustained-release tablets. Through the design of an automatic sampling mechanism, it realizes the automated and rapid detection of the release rate of sustained-release tablets, reduces the error of human operation, and improves the detection efficiency and accuracy.

[0018] 2. This utility model provides a rapid detection device for the release rate of trazodone hydrochloride sustained-release tablets. By simulating the motion mechanism, it simulates the motion state of the sustained-release tablet in the human body, making the detection results closer to the actual situation and improving the reliability of the detection. Attached Figure Description

[0019] Figure 1 This is a three-dimensional structural diagram of the present invention;

[0020] Figure 2 This is a three-dimensional structural diagram of the automatic sampling mechanism of this utility model;

[0021] Figure 3 This is a three-dimensional structural diagram of the internal structure of the suction cup of this utility model;

[0022] Figure 4 This is a three-dimensional structural diagram of the simulated motion mechanism of this utility model;

[0023] Figure 5 This is a three-dimensional structural diagram of the simulated motion mechanism of this utility model.

[0024] In the diagram: 1. Mounting box; 2. Observation window; 3. Partition; 4. Detection bucket; 5. Cover plate; 6. Handle; 7. Groove; 8. Automatic sampling mechanism; 80. Mounting frame; 81. Electric push rod; 82. Mounting plate; 83. Suction cylinder; 84. Suction tube; 85. Piston block; 86. Connecting rod; 87. Fixing block; 9. Simulated motion mechanism; 90. Fixing ring; 91. Motor; 92. Rotating shaft; 93. Connecting block; 94. Tooth block; 95. Gear. Detailed Implementation

[0025] To make the technical means, creative features, objectives and effects of this utility model easier to understand, the present utility model will be further described below in conjunction with specific embodiments.

[0026] like Figure 1-5 As shown, a rapid detection device for the release rate of trazodone hydrochloride sustained-release tablets includes a mounting box 1, an observation window 2 fixedly connected to the outside of the mounting box 1, a partition 3 fixedly connected to the inside of the mounting box 1, two detection barrels 4 arranged inside the mounting box 1, a cover plate 5 arranged on the top of the detection barrels 4, a handle 6 fixedly connected to the top of the cover plate 5, a slot 7 opened on the top of the cover plate 5, an automatic sampling mechanism 8 arranged on the top of the mounting box 1, and a simulated motion mechanism 9 arranged at the bottom of one of the detection barrels 4;

[0027] The automatic sampling mechanism 8 includes a mounting frame 80, which is fixedly connected to the top of the mounting box 1. An electric push rod 81 is fixedly connected to the top of the mounting frame 80. A mounting plate 82 is fixedly connected to the output end of the electric push rod 81. Two suction cylinders 83 are fixedly connected to the bottom of the mounting plate 82. A suction tube 84 is fixedly connected to the bottom of the suction cylinder 83. A piston block 85 is slidably connected inside the suction cylinder 83. A connecting rod 86 is fixedly connected to the top of the piston block 85. A fixing block 87 is fixedly connected to the top of the connecting rod 86.

[0028] It should be noted that when it is necessary to test the release rate of sustained-release tablets, the electric push rod 81 is activated. The electric push rod 81 drives the mounting plate 82 to descend, so that the pipette 84 enters the test barrel 4. The fixing block 87 and the mounting frame 80 abut against each other, so that the connecting rod 86 and the piston block 85 stop moving. The suction cylinder 83 continues to move, and the piston block 85 slides in the suction cylinder 83, generating negative pressure, thereby realizing the aspiration of the sample.

[0029] The simulated motion mechanism 9 includes a fixed ring 90 and a motor 91. The inner side of the fixed ring 90 is fixedly connected to the outer periphery of the detection barrel 4. A gear 95 is fixedly connected to the outer periphery of one end of the fixed ring 90. The outer side of the motor 91 is fixedly connected to the outer side of the mounting box 1. A rotating shaft 92 is fixedly connected to the output end of the motor 91. A connecting block 93 is fixedly connected to the outer side of the rotating shaft 92. A toothed block 94 is fixedly connected to the outer side of the connecting block 93.

[0030] It should be noted that when it is necessary to simulate the movement of the sustained-release tablet in the human body, the motor 91 (the motor 91 is a slow-speed motor) is started. The motor 91 drives the rotating shaft 92 to rotate. The rotating shaft 92 drives the gear 95 to rotate through the connecting block 93 and the toothed block 94. The gear 95 drives the fixed ring 90. The fixed ring 90 drives the detection barrel 4 to swing back and forth in a reciprocating motion, so that the inside of the detection barrel 4 shakes, thereby simulating the movement of the sustained-release tablet in the gastrointestinal tract.

[0031] like Figure 2 , Figure 3 As shown, the outer periphery of the connecting rod 86 is slidably connected to the inside of the mounting plate 82, and the outer periphery of the connecting rod 86 is slidably connected to the inside of the mounting bracket 80.

[0032] It should be noted that the outer periphery of the connecting rod 86 is slidably connected to the inside of the mounting plate 82, and the outer periphery of the connecting rod 86 is slidably connected to the inside of the mounting bracket 80, so that the connecting rod 86 can slide when the mounting plate 82 moves upward, preventing the piston block 85 from squeezing out the extracted sample.

[0033] like Figure 2 , Figure 3 As shown, the top of the fixing block 87 and the mounting bracket 80 abut together.

[0034] It should be noted that the top of the fixing block 87 and the mounting bracket 80 abut against each other, so that the piston block 85 can move relative to the suction cylinder 83.

[0035] like Figure 4 , Figure 5 As shown, the outer circumference of the fixing ring 90 is rotatably connected to the inside of the partition 3, and the outer circumference of the fixing ring 90 is rotatably connected to the inside of the mounting box 1.

[0036] It should be noted that the connection method of the fixing ring 90 allows the detection barrel 4 to shake.

[0037] like Figure 4 , Figure 5 As shown, the tooth block 94 and the gear 95 mesh together.

[0038] It should be noted that the meshing between the tooth block 94 and the gear 95 enables the tooth block 94 to drive the gear 95 to rotate.

[0039] like Figure 4 As shown, the cover plate 5 and the detection barrel 4 are interlocked.

[0040] It should be noted that the cover plate 5 and the detection barrel 4 are interlocked, so that the cover plate 5 can seal the detection barrel 4.

[0041] The working principle of this utility model is as follows: Before testing, add an equal amount of dissolving medium, such as artificial gastric juice, to the two test barrels 4. Place the trazodone hydrochloride sustained-release tablets into the test barrels 4 respectively, close the cover plate 5 tightly, and set the operating parameters of the simulated motion mechanism 9, such as the swing frequency and time, and the sampling interval of the automatic sampling mechanism 8 through the controller.

[0042] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of this utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claims. The scope of protection of this utility model is defined by the appended claims and their equivalents.

Claims

1. A rapid detection device for the release rate of trazodone hydrochloride sustained-release tablets, comprising a mounting box (1), characterized in that: An observation window (2) is fixedly connected to the outside of the mounting box (1), a partition (3) is fixedly connected inside the mounting box (1), two detection barrels (4) are set inside the mounting box (1), a cover plate (5) is set on the top of the detection barrel (4), a handle (6) is fixedly connected to the top of the cover plate (5), a slot (7) is opened on the top of the cover plate (5), an automatic sampling mechanism (8) is set on the top of the mounting box (1), and a simulated motion mechanism (9) is set at the bottom of one of the detection barrels (4). The automatic sampling mechanism (8) includes a mounting frame (80), which is fixedly connected to the top of the mounting box (1) on the outside. An electric push rod (81) is fixedly connected to the top of the mounting frame (80). An installation plate (82) is fixedly connected to the output end of the electric push rod (81). Two suction cylinders (83) are fixedly connected to the bottom of the installation plate (82). A suction tube (84) is fixedly connected to the bottom of the suction cylinder (83). A piston block (85) is slidably connected inside the suction cylinder (83). A connecting rod (86) is fixedly connected to the top of the piston block (85). A fixing block (87) is fixedly connected to the top of the connecting rod (86). The simulated motion mechanism (9) includes a fixed ring (90) and a motor (91). The inner side of the fixed ring (90) is fixedly connected to the outer periphery of the detection barrel (4). A gear (95) is fixedly connected to the outer periphery of one end of the fixed ring (90). The outer side of the motor (91) is fixedly connected to the outer side of the mounting box (1). A rotating shaft (92) is fixedly connected to the output end of the motor (91). A connecting block (93) is fixedly connected to the outer side of the rotating shaft (92). A toothed block (94) is fixedly connected to the outer side of the connecting block (93).

2. The rapid detection device for the release rate of trazodone hydrochloride sustained-release tablets according to claim 1, characterized in that: The outer periphery of the connecting rod (86) is slidably connected to the inside of the mounting plate (82), and the outer periphery of the connecting rod (86) is slidably connected to the inside of the mounting bracket (80).

3. The rapid detection device for the release rate of trazodone hydrochloride sustained-release tablets according to claim 1, characterized in that: The top of the fixing block (87) and the mounting bracket (80) abut against each other.

4. The rapid detection device for the release rate of trazodone hydrochloride sustained-release tablets according to claim 1, characterized in that: The outer periphery of the straw (84) is slidably connected to the inside of the groove (7).

5. The rapid detection device for the release rate of trazodone hydrochloride sustained-release tablets according to claim 1, characterized in that: The outer circumference of the fixing ring (90) is rotatably connected to the inside of the partition (3), and the outer circumference of the fixing ring (90) is rotatably connected to the inside of the mounting box (1).

6. The rapid detection device for the release rate of trazodone hydrochloride sustained-release tablets according to claim 1, characterized in that: The tooth block (94) and the gear (95) mesh with each other.

7. The rapid detection device for the release rate of trazodone hydrochloride sustained-release tablets according to claim 1, characterized in that: The cover plate (5) and the detection barrel (4) are engaged.

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