Non-contact induced anesthesia device for mouse modeling

Abstract

This invention discloses a non-contact induction anesthesia device for mouse modeling, belonging to the field of veterinary instrument technology. The anesthesia device includes a cage with a wire mesh structure, inside which a movable partition divides the cage into a rearing area and an anesthesia area. A sealing plate is fixed to one side of the cage, with an opening on the sealing plate leading to an anesthesia chamber. The anesthesia chamber is equipped with a sealing gate and a push-pull compartment. The push-pull compartment has a support compartment and an end cap, the end cap of which can close the opening of the anesthesia chamber. The anesthesia chamber has an air inlet and an air outlet. In use, the operator pushes the partition outside the cage to drive the mouse into the anesthesia chamber, closes the sealing gate, and introduces anesthetic gas through the air inlet. After the mouse is anesthetized, the push-pull compartment is pulled out to remove the mouse. This invention avoids handling mice by hand, reducing stress and occupational exposure risks. Simultaneously, the sealing structure effectively controls the escape of anesthetic gas, improving the safety and efficiency of experimental operations.

Description

Technical Field

[0001] This utility model belongs to the field of veterinary instrument technology, specifically relating to a non-contact induction anesthesia device for mouse modeling. Background Technology

[0002] In biomedical research, animal modeling is a technique for artificially replicating human diseases or specific pathological states in laboratory animals. It is a core step in drug screening, mechanism research, and preclinical evaluation. Mice, due to their clear genetic background, short reproductive cycle, and high homology with the human genome, have become the most commonly used rodent in modeling experiments. Before modeling surgeries such as tumor transplantation, myocardial ischemia, and liver and kidney resection, mice need to be anesthetized to fix their position and eliminate pain. Compared to injection anesthesia, inhalation anesthesia has advantages such as controllable depth of anesthesia, rapid recovery, and less interference with physiological indicators; therefore, inhalation anesthetics such as isoflurane are widely used in laboratories.

[0003] Currently, the common laboratory procedure involves the operator manually removing mice from their cages, placing them in a separate anesthesia induction box, administering anesthetic gas to induce anesthesia, and then removing the mouse after it collapses. The mouse is then transferred to an operating table for modeling. To address the needs of modeling experiments, some patents have improved the mouse cages. For example, Chinese patent CN201821911469.0 discloses a modeling mouse cage that divides the cage into several independent small cages with partitions, and includes feeding troughs, medication troughs, and water supply pipes, facilitating independent feeding of experimental mice, monitoring of mouse vital signs, and accurate administration of food and medication dosages. However, this solution only addresses the feeding and medication issues during modeling; it does not address the anesthesia process. The mouse still needs to be removed from the cage and transferred to a separate anesthesia device. This separate "grab-transfer-anesthesia-removal" process has significant drawbacks in practical applications. On the one hand, handling mice with bare hands induces a stress response, causing non-physiological fluctuations in their heart rate, blood pressure, and hormone levels. This interference directly affects the uniformity and success rate of the modeling surgery. Furthermore, frequent contact with animals poses an occupational exposure risk of bites for the operator. On the other hand, after induction in the anesthesia box, the operator must open the lid to remove the mouse. This action causes residual anesthetic gas to escape instantly into the operating environment, posing a potential health threat to the experimenters over time. In addition, the independent rearing cage and anesthesia box require the mouse to undergo a transition from a familiar to an unfamiliar environment, further exacerbating its anxiety and struggle. Therefore, it is urgent to improve existing anesthesia devices and operating methods for mouse modeling to solve the technical problem of smoothly transitioning mice from a rearing state to anesthesia while avoiding direct handling and minimizing environmental changes, and simultaneously controlling the escape of anesthetic gas. Utility Model Content

[0004] The purpose of this invention is to overcome the shortcomings of existing technologies, such as stress response, occupational exposure risk and anesthetic gas leakage caused by handling mice with bare hands, and to provide a non-contact induction anesthesia device for mouse modeling, so as to realize non-contact operation from feeding to anesthesia and complete anesthesia in a closed environment.

[0005] To achieve the above technical objectives, the present invention adopts the following technical solution: A non-contact induction anesthesia device for mouse modeling includes a cage with a wire mesh structure, and further includes: A movable partition is provided inside the rearing cage to divide the rearing cage into a rearing area and a waiting area for anesthesia. The movable partition is slidably engaged with the rearing cage and can slide horizontally to one side. A sealing plate is fixedly installed on the side of the feeding cage body opposite to the sliding direction of the movable partition plate, and at least one channel opening is provided on the sealing plate; At least one anesthesia chamber is fixedly disposed on the outside of the sealing plate and corresponds one-to-one with the channel opening; the anesthesia chamber has an internal cavity communicating with the channel opening. A sealing gate is slidably mounted on the outside of the sealing plate, each sealing gate covering one of the channel openings and slidable to open or close the channel openings; Each of the anesthesia chambers is equipped with an air inlet and an air outlet for connecting to an external anesthesia machine.

[0006] Furthermore, each of the anesthesia chambers is provided with a push-pull chamber, and the end of the anesthesia chamber away from the sealing plate is provided with an opening. The push-pull chamber is slidably disposed in the anesthesia chamber and can be pushed in or pulled out from the opening. The push-pull chamber has a support chamber for carrying mice and an end cap fixedly disposed at one end of the support chamber. When the push-pull chamber is in the pushed-in state, the end cap closes the opening. When the push-pull chamber is in the pulled-out state, the end cap separates from the opening.

[0007] Furthermore, the air inlet is located on one end of the anesthesia chamber near the end cap, and the air outlet is located on one end of the anesthesia chamber near the sealing plate.

[0008] Furthermore, a push-pull handle is provided on the outer side of the end cap.

[0009] Furthermore, the sealing plate is provided with a limiting guide rail for the sealing gate to slide up and down, and the connection between the sealing plate and the anesthesia chamber is provided with an opening for the sealing gate to be inserted. The sealing gate is inserted into the opening and slides up and down along the limiting guide rail. When the sealing gate slides to the lowest position, the passage is closed, and when the sealing gate slides upward, the passage is opened.

[0010] Furthermore, the top of the breeding cage is provided with a slide rail, and the top of the movable partition is fixed with a slider that slides in cooperation with the slide rail.

[0011] Furthermore, the slider is provided with a handle, and the top wire mesh of the feeding cage is provided with a slot extending in the sliding direction, and the handle extends upward from the slot.

[0012] Furthermore, the movable partition is provided with an openable and closable passage door, which slides up and down with the movable partition and connects the feeding area and the anesthesia area.

[0013] Furthermore, each channel opening on the sealing plate is provided with a guide plate, which extends from the channel opening into the interior of the area to be anesthetized. A clearance groove is provided on the movable partition plate corresponding to the position of the guide plate. The clearance groove is provided on the passage door. When the movable partition plate moves to its limit position towards the sealing plate, the guide plate enters the clearance groove.

[0014] This invention discloses a non-contact anesthesia device for mouse modeling. Its core feature is placing the anesthesia chamber outside the rearing cage and using a movable partition to achieve non-contact herding within the cage. Sealed anesthesia and non-contact removal are achieved through a sealed gate and a push-pull mechanism. Compared to existing technologies, this invention offers the following advantages: First, the operator's hands do not need to directly contact the mice during the entire operation, avoiding stress responses induced by handling, improving the uniformity and success rate of the modeling surgery, and eliminating the occupational exposure risk of being bitten. Second, the anesthetic gas circulates within the sealed anesthesia chamber. After anesthesia, residual anesthetic gas is discharged through the vent before the push-pull mechanism is pulled out to remove the mouse. The anesthetic gas does not escape into the operating environment, ensuring the occupational health of the experimental personnel. Third, the mice remain in a familiar rearing cage environment during the process of being herded from the rearing area to the anesthesia chamber, eliminating the need for environmental changes and reducing anxiety and struggle. Fourth, by setting up multiple anesthesia chambers in parallel and equipping them with independently controlled sealed gates and push-pull mechanisms, continuous or batch anesthesia of multiple mice can be achieved, significantly improving experimental efficiency. Fifth, the coordinated design of the guide vane and the clearance groove ensures a smooth driving process, further improving the reliability and convenience of operation. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the overall structure of the non-contact induction anesthesia device used for mouse modeling in this embodiment of the present invention.

[0016] Figure 2 This is a partial cross-sectional schematic diagram of the non-contact induction anesthesia device for mouse modeling in this embodiment of the present invention with the anesthesia chamber closed.

[0017] Figure 3 This is a partial cross-sectional view of the non-contact induction anesthesia device for mouse modeling in this embodiment of the present invention with the anesthesia chamber open.

[0018] The following are the markings in the attached diagram: 1. Feeding cage; 11. Feeding area; 12. Anesthesia waiting area; 13. Slide rail; 14. Slot; 2. Movable partition; 21. Sliding block; 22. Handle; 23. Clearance slot; 24. Passage door; 3. Sealing plate; 31. Passage opening; 32. Flow guide plate; 33. Limiting guide rail; 4. Anesthesia chamber; 5. Sealing gate; 6. Push-pull chamber; 61. End cover; 62. Support chamber; 63. Push-pull handle; 7. Air inlet; 8. Air outlet. Detailed Implementation

[0019] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present utility model without creative effort are within the scope of protection of the present utility model.

[0020] In the description of this utility model, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0021] In existing technologies, the anesthesia procedure for mouse modeling surgery requires manual handling and transfer to an independent anesthesia box. This process can induce stress in mice and also presents the problem of anesthetic gas leakage. Therefore, to address these issues, this application provides a contactless induction anesthesia device for mouse modeling, such as... Figures 1 to 3As shown, the anesthesia device includes a rearing cage 1 with a wire mesh structure. A movable partition 2 is provided inside the rearing cage 1, dividing it into a rearing area 11 and an anesthesia area 12. The movable partition 2 is slidably engaged with the rearing cage 1 and can slide horizontally to one side. A sealing plate 3 is fixedly installed on the side of the rearing cage 1 opposite to the sliding direction of the movable partition 2, and the sealing plate 3 has at least one channel opening 31. At least one anesthesia chamber 4 is fixedly installed on the outside of the sealing plate 3, with each anesthesia chamber 4 corresponding to one of the channel openings 31, and each anesthesia chamber 4 having an internal cavity communicating with the channel opening 31. A sealing gate 5 is slidably installed on the outside of the sealing plate 3, each sealing gate 5 covering one channel opening 31, which can be opened or closed by sliding. Each anesthesia chamber 4 has an air inlet 7 and an air outlet 8 for connecting to an external anesthesia machine.

[0022] The rearing cage 1 features a mesh structure welded from stainless steel wire, facilitating observation of the mice's condition and ventilation. The movable partition 2 also uses a wire mesh, with its edges maintaining a gap from the inner wall of the rearing cage 1, and is moved smoothly via a sliding mechanism at the top. The sealing plate 3 is a solid plate replacing the original wire mesh sidewalls, providing a sealed base to prevent anesthetic gas leakage from the passageway. The anesthesia chamber 4 is made of transparent plastic or plexiglass, allowing for easy observation of the mice's condition. The sealing gate 5 closes the passageway 31 after the mice have been driven away, ensuring that the anesthesia chamber 4 forms an independent, sealed space.

[0023] Specifically, when anesthesia modeling is required for mice, the experimenter opens the sealing gate 5 and pushes the movable partition 2 horizontally from far to near, causing the partition 2 to slowly slide towards the side where the sealing plate 3 is located. At this time, the space of the anesthesia area 12 continuously shrinks due to the pressure of the partition. As the space is continuously compressed, driven by instinct and the pushing force of the plate, the mouse moves towards the passage 31. Unable to escape elsewhere, without manual contact, it will passively and smoothly pass through the passage 31 on the sealing plate 3, thus precisely entering the internal cavity of the anesthesia chamber 4. Subsequently, the operator closes the sealing gate 5, cutting off the connection between the anesthesia chamber 4 and the outside world and the cage, and delivers a mixture of anesthetic carrier gas and a set concentration of isoflurane vapor into the cavity through the anesthesia machine tubing connected to the air inlet 7 and the air outlet 8, implementing rapid induction in a local micro-volume.

[0024] This technical solution enables a completely contactless operation from driving away to removal, effectively avoiding stress during the grasping process and the escape of exhaust gas.

[0025] The present invention further proposes that each anesthesia chamber 4 is provided with a push-pull chamber 6. The end of the anesthesia chamber 4 away from the sealing plate 3 is provided with an opening. The push-pull chamber 6 is slidably disposed in the anesthesia chamber 4 and can be pushed in or pulled out from the opening. The push-pull chamber 6 has a support chamber 62 for carrying mice and an end cap 61 fixedly disposed at one end of the support chamber 62. When the push-pull chamber 6 is in the pushed-in state, the end cap 61 closes the opening. When the push-pull chamber 6 is in the pulled-out state, the end cap 61 separates from the opening.

[0026] The sliding compartment 6, resembling a drawer, is located within the anesthesia chamber 4 and can slide back and forth. The support compartment 62 is typically designed as a top-opening groove or shallow tray, with its bottom surface for the mouse to rest and lie down. The bottom surface can be further textured with anti-slip material to prevent the mouse from sliding inside. The end cap 61 is sized to match the opening; when pushed in, the end cap 61 fits tightly against the end face of the anesthesia chamber 4, forming an airtight seal. During anesthesia, the sliding compartment 6 remains in the pushed-in position, the end cap 61 closes the opening, and the sealing gate 5 closes the passage opening 31, preventing anesthetic gas leakage. After anesthesia, residual gas can be expelled through the vent 8 before the mouse is removed, preventing anesthetic gas from escaping into the operating environment. To remove the mouse, simply pull out the sliding compartment 6, and the anesthetized mouse can be taken out from the support compartment 62. As an alternative embodiment, those skilled in the art can also attach an elastic sealing gasket to the inner surface of the end cap 61 of the sliding compartment 6 to further improve the sealing effect. This structure allows the mouse to be handled without being directly grasped during the anesthesia process. Before removing the mouse after anesthesia, the anesthetic gas in the anesthesia chamber is first expelled through the air outlet 8, which prevents gas from escaping when the push-pull chamber 6 is opened, thus improving the safety and convenience of operation.

[0027] The present invention further proposes that the air inlet 7 is located on the anesthesia chamber 4 near the end cap 61, and the air outlet 8 is located on the anesthesia chamber 4 near the sealing plate 3.

[0028] The arrangement of the air inlet and outlet ensures that the anesthetic gas flows in from the end near the end cap 61 and flows out from the end near the sealing plate 3, with the gas flow direction consistent with the length of the anesthesia chamber 4, covering the entire chamber space. In this way, when the mouse enters the support chamber 62 with its head facing the end cap 61 and its tail facing the sealing plate 3, a fresh, mixed anesthetic gas flow is introduced from the air inlet 7 at the front of the mouse, flowing directionally from the end cap 61 (where the mouse's head and mouth / nose are located) towards the sealing plate 3 at the tail. After anesthesia, the gas is drawn back to the external anesthesia machine collection system through the air outlet 8. This specific airflow distribution ensures that the high concentration of anesthetic gas preferentially forms a directional convection field in the mouse's breathing area (mouth and nose), avoiding localized vortices and dead zones at one end. This ensures that the mouse can quickly inhale sufficient anesthetic gas and collapse rapidly, significantly shortening the anesthesia induction latency period. As a specific implementation, the air inlet 7 and outlet 8 can use standard Luer connectors for easy and quick connection to the anesthesia machine tubing. This technical solution optimizes the gas flow path, making the anesthesia process more efficient and reliable.

[0029] The present invention further proposes that a push-pull handle 63 is provided on the outer side of the end cap 61.

[0030] The push-pull handle 63, which can be an arc-shaped handle or a T-shaped handle, is fixedly installed in the center of the outer surface of the end cap 61. The operator can easily push or pull the push-pull chamber 6 in or out by holding the handle 63, without directly contacting the end cap 61 or other parts of the chamber. This design is ergonomic, effortless to operate, and especially useful when multiple anesthesia chambers are used side-by-side, allowing for quick identification and operation of the corresponding chamber 6. The handle 63 also helps the operator control the pushing and pulling force, avoiding excessive force that could disturb the mice. This structure enhances operational convenience and experimental efficiency.

[0031] The present invention further proposes that the sealing plate 3 is provided with a limiting guide rail 33 for the sealing gate 5 to slide up and down, and the connection between the sealing plate 3 and the anesthesia chamber 4 is provided with an opening for the sealing gate 5 to be inserted. The sealing gate 5 is inserted into the opening and slides up and down along the limiting guide rail 33. When the sealing gate 5 slides to the lowest position, the passage 31 is closed. When the sealing gate 5 slides upward, the passage 31 is opened.

[0032] Among them, the limiting guide rail 33 has two parallel grooves and is vertically fixed on both sides of the channel opening 31 on the outer surface of the sealing plate 3. The opening is located above the connection between the sealing plate 3 and the anesthesia chamber 4 and is a long and narrow slit, the width of which matches the thickness of the sealing gate 5. The sealing gate 5 is a rectangular flat plate, and both side edges thereof are embedded in the limiting guide rail 33. On the premise of ensuring basic sealing, this opening allows the plug-shaped sealing gate 5 to penetrate vertically. When it is necessary to close the channel opening 31, the sealing gate 5 is pushed downward to the lowest position, and the gate completely covers the channel opening 31 and is inserted into the opening to form a seal. When it is necessary to open it, the sealing gate 5 is lifted upward, the channel opening 31 is exposed, and the mouse can enter the anesthesia chamber 4 from the waiting anesthesia area 12. As a specific implementation manner, a pull ring can be provided at the upper end of the sealing gate 5 for convenient operation. This structure realizes the independent control of the channel opening, and the sliding operation is simple and reliable with good sealing performance.

[0033] The present utility model further proposes that a slide rail 13 is provided at the top of the breeding cage body 1, and a slider 21 slidably engaged with the slide rail 13 is fixedly provided at the top of the movable partition plate 2. <The present utility model further proposes that a slide rail 13 is provided at the top of the breeding cage body 1, and a slider 21 slidably engaged with the slide rail 13 is fixedly provided at the top of the movable partition plate 2.

[0034] Among them, the slide rail 13 is two parallel metal tracks fixed below the wire mesh at the top of the breeding cage body 1 or on the wire mesh skeleton. The slider 21 is a sliding block matched with the slide rail 13 and is fixedly connected to both sides of the top of the movable partition plate 2 by means of bolts or the like. The sliding part of the slider 21 is embedded in the slide rail 13 and can slide freely along the track direction. This hanging sliding fit configuration enables the movable partition plate 2 to maintain a preset small gap with the bottom surface of the breeding cage and the side walls of the cage body at its lower edge and both side edges during horizontal movement, avoiding friction and jamming between the plate body and the bedding and feces at the bottom during horizontal sliding, ensuring stable torque when the experimenter pushes externally, and preventing the cage body from shaking caused by sudden change of driving force and stimulating other mice in the cage.

[0035] <000008>

[0036] Among them, the handle 22 is a vertically arranged handle, and its lower end is fixedly connected to the slider 21. The slot 14 is a long strip-shaped slit penetrating the wire mesh, and its length matches the moving stroke of the movable partition plate 2. The operator only needs to hold the handle 22 and push and pull along the direction of the slot 14 to drive the slider 21 and the movable partition plate 2 to move in the cage. Due to the guiding effect of the slot 14, the handle 22 will not deviate. This design realizes the linkage of the structure inside the cage by operating outside the cage. The operator does not need to open the cage cover, completely avoiding direct contact with the mice, and reducing the risks of stress and bites.

[0037] The present invention further proposes that the movable partition 2 is provided with an openable and closable passage door 24, which slides up and down with the movable partition 2, and the passage door 24 connects the feeding area 11 and the anesthesia waiting area 12.

[0038] The passageway 24 is a movable gate that can slide up and down, located at the lower part of the movable partition 2. When the passageway 24 slides upward to open, a passage is formed between the rearing area 11 and the anesthesia area 12, allowing researchers to guide mice from the rearing area to the anesthesia area, or to return mice that have been anesthetized and driven away from the anesthesia area to the rearing area. When the passageway 24 is closed, the two areas are completely isolated, preventing mice from escaping back to the rearing area during the driving process. The sliding of the passageway 24 is achieved by setting vertical grooves on the partition 2. This structure makes the transfer and zoning management of mice more flexible, improving the convenience of experimental operations.

[0039] The present invention further proposes that each channel opening 31 on the sealing plate 3 is provided with a guide plate 32, the guide plate 32 extends from the channel opening 31 into the interior of the anesthesia area 12, and the movable partition plate 2 is provided with a relief groove 23 corresponding to the position of the guide plate 32. The relief groove 23 is provided on the passage door 24. When the movable partition plate 2 moves to the limit position in the direction of the sealing plate 3, the guide plate 32 enters the relief groove 23.

[0040] The guide plate 32 consists of two parallel baffles fixed to the inner edge of the passage opening 31, extending towards the anesthesia area 12. When the movable partition plate 2 moves towards the sealing plate 3, the space in the anesthesia area 12 gradually shrinks. Driven by their escape instinct, mice will naturally move towards the passage opening 31 along the guide plate 32, thus smoothly entering the anesthesia chamber 4. An avoidance groove 23 is located on the passage door 24, its position corresponding to the guide plate 32, and its shape matching the shape of the guide plate 32. When the partition plate 2 moves to its extreme position, the guide plate 32 precisely embeds into the avoidance groove 23, allowing the partition plate 2 to completely contact the sealing plate 3, ensuring no mice remain in the anesthesia area 12. In one specific implementation, the spacing between the guide plates 32 is slightly larger than the width of the mouse's body. This design effectively solves the problem of mice hesitating, lingering, or escaping during the driving process, improving the success rate of driving and avoiding physical interference between the partition plate and the guide plate.

[0041] The overall working principle of this device is briefly described below: This device is used directly as a daily rearing cage for mice. Normally, mice are kept in the rearing area 11 of cage 1. When it is necessary to anesthetize the mice in the cage for modeling, the mice are guided to the anesthesia area 12 through the passage door 24 on the movable partition plate 2, and then the passage door 24 is closed. At this time, the push-pull chamber 6 has been pre-push-in into the anesthesia chamber 4, the end cap 61 closes the opening of the anesthesia chamber 4, and the sealing gate 5 is in the open channel 31 state. The operator holds the handle 22 extending from the slot 14 and pushes the slider 21 to slide the movable partition plate 2 towards the sealing plate 3, gradually compressing the space of the anesthesia area 12. Guided by the guide plate 32, the mice enter the anesthesia chamber 4 through the channel 31 and stand or lie on the support chamber 62 of the push-pull chamber 6. Then, the sealing gate 5 is slid down to close the channel 31, forming a sealed anesthesia space. Then, connect the external anesthesia machine to the air inlet 7 and the air outlet 8, and introduce anesthetic gas to anesthetize the mouse. After anesthesia, first draw the anesthetic gas in the anesthesia chamber 4 back to the external anesthesia machine gas collection system through the air outlet 8, then turn off the anesthesia machine, and then pull the push-pull handle 63 outward. The support chamber 62, carrying the anesthetized mouse, is then extracted from the anesthesia chamber. The entire anesthesia process does not require handling the mouse by hand, and the anesthetic gas is sealed inside the anesthesia chamber 4, so there is no waste gas escaping when the mouse is removed.

[0042] The above description is merely a preferred embodiment of this application and is not intended to limit this application. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of this application should be included within the protection scope of this application.

Claims

1. A non-contact induction anesthesia device for mouse modeling, comprising a breeding cage (1) with a wire mesh structure, characterized in that, Also includes: A movable partition (2) is provided inside the feeding cage (1) to divide the feeding cage (1) into a feeding area (11) and an anesthesia area (12). The movable partition (2) is slidably engaged with the feeding cage (1) and can slide horizontally to one side. A sealing plate (3) is fixedly installed on the side of the feeding cage (1) opposite to the sliding direction of the movable partition plate (2), and at least one channel opening (31) is provided on the sealing plate (3). At least one anesthesia chamber (4) is fixedly disposed on the outside of the sealing plate (3) and corresponds one-to-one with the channel opening (31). The anesthesia chamber (4) has an internal cavity communicating with the channel opening (31). A sealing gate (5) is slidably installed on the outside of the sealing plate (3), each of the sealing gates (5) covering one of the passage openings (31) and slidable to open or close the passage opening (31). Each of the anesthesia chambers (4) is provided with an air inlet (7) and an air outlet (8) for connecting to an external anesthesia machine.

2. The non-contact induction anesthesia device for mouse modeling according to claim 1, characterized in that, Each of the anesthesia chambers (4) is provided with a push-pull chamber (6). The anesthesia chamber (4) has an open opening at one end away from the sealing plate (3). The push-pull chamber (6) is slidably disposed in the anesthesia chamber (4) and can be pushed in or pulled out from the open opening. The push-pull chamber (6) has a support chamber (62) for carrying mice and an end cap (61) fixedly disposed at one end of the support chamber (62). When the push-pull chamber (6) is in the pushed-in state, the end cap (61) closes the open opening. When the push-pull chamber (6) is in the pulled-out state, the end cap (61) separates from the open opening.

3. The non-contact induction anesthesia device for mouse modeling according to claim 2, characterized in that, The air inlet (7) is located on the anesthesia chamber (4) near the end cap (61), and the air outlet (8) is located on the anesthesia chamber (4) near the sealing plate (3).

4. The non-contact induction anesthesia device for mouse modeling according to claim 2 or 3, characterized in that, The end cap (61) is provided with a push-pull handle (63) on the outside.

5. The non-contact induction anesthesia device for mouse modeling according to claim 1, characterized in that, The sealing plate (3) is provided with a limiting guide rail (33) for the sealing gate (5) to slide up and down. The connection between the sealing plate (3) and the anesthesia chamber (4) is provided with an opening for the sealing gate (5) to be inserted. The sealing gate (5) is inserted into the opening and slides up and down along the limiting guide rail (33). When the sealing gate (5) slides to the lowest position, the passage opening (31) is closed. When the sealing gate (5) slides up, the passage opening (31) is opened.

6. The non-contact induction anesthesia device for mouse modeling according to claim 1, characterized in that, The top of the feeding cage (1) is provided with a slide rail (13), and the top of the movable partition plate (2) is fixed with a slider (21) that slides in cooperation with the slide rail (13).

7. The non-contact induction anesthesia device for mouse modeling according to claim 6, characterized in that, The slider (21) is provided with a handle (22), and the top wire mesh of the feeding cage (1) is provided with a slot (14) extending in the sliding direction, and the handle (22) extends upward from the slot (14).

8. The non-contact induction anesthesia device for mouse modeling according to claim 6, characterized in that, The movable partition (2) is provided with an openable and closable passage door (24), which slides up and down with the movable partition (2), and the passage door (24) connects the feeding area (11) and the anesthesia area (12).

9. The non-contact induction anesthesia device for mouse modeling according to claim 8, characterized in that, Each channel opening (31) on the sealing plate (3) is provided with a guide plate (32), the guide plate (32) extends from the channel opening (31) into the interior of the anesthesia area (12), and the movable partition plate (2) is provided with a relief groove (23) corresponding to the position of the guide plate (32). The relief groove (23) is opened on the passage door (24). When the movable partition plate (2) moves to the limit position towards the sealing plate (3), the guide plate (32) enters the relief groove (23).

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