A device for equivalent addition of donepezil hydrochloride tablets

Abstract

The utility model discloses a kind of donepezil hydrochloride tablets equivalent progressive addition mixing devices, it is related to pharmaceutical technical field, including fixed cylinder, the side of fixed cylinder is provided with the feeding mechanism for feeding, the top of fixed cylinder is fixedly connected with feeding pipe and is penetrated, the inside of fixed cylinder is provided with the stirring mechanism for mixing, the inner wall of fixed cylinder is slidably connected with mixing bucket one and mixing bucket two, the inner wall of fixed cylinder bottom end is fixedly connected with mixing bucket three, the bottom of mixing bucket one, mixing bucket two and mixing bucket three is all provided with the unloading mechanism for opening and closing, the side of mixing bucket one and mixing bucket two is all fixedly connected with fixed block, the bottom of fixed block is fixedly connected with spring and telescopic rod, solved if it is through the method of adding batch quantity to mix, not only time-consuming and laborious, while opening and closing feeding pipe every time, it will increase the risk of introducing foreign contamination source in the process of mixing drug, possibly affect the finished drug quality problem.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical technology, specifically to a device for the incremental mixing of donepezil hydrochloride tablets. Background Technology

[0002] Donepezil hydrochloride tablets are a widely used drug for the treatment of Alzheimer's disease. The quality of the tablets directly affects the efficacy of the drug and the safety of patients. Since the clinical dose of donepezil hydrochloride is usually small, while the excipients (such as starch, microcrystalline cellulose, etc.) account for a large proportion, direct mixing may lead to uneven distribution of the active ingredient and affect the uniformity of the tablet content.

[0003] Therefore, in the formulation production process, the equal-volume incremental mixing method is usually used to mix the pharmaceutical raw materials. By gradually increasing the mixing volume, the trace amounts of active pharmaceutical ingredient and excipients are fully dispersed, thereby avoiding excessively high or low local concentrations. However, if the method of adding the drug in batches is used for mixing, it will not only be time-consuming and labor-intensive, but also increase the risk of introducing external contaminants into the drug during the mixing process each time the feeding tube is opened and closed, which may affect the quality of the finished drug. Therefore, it is necessary to design an automatic equal-volume incremental mixing device for donepezil hydrochloride tablets. Utility Model Content

[0004] The purpose of this invention is to provide a device for the equal-volume addition and mixing of donepezil hydrochloride tablets, so as to solve the problems mentioned in the background art.

[0005] To achieve the above objectives, this utility model provides the following technical solution: a donepezil hydrochloride tablet equal-volume incremental mixing device, comprising a fixed cylinder, a feeding mechanism for adding materials is provided on one side of the fixed cylinder, a feeding pipe is fixedly connected through the top of the fixed cylinder, a stirring mechanism for mixing is provided inside the fixed cylinder, a mixing tank one and a mixing tank two are slidably connected to the inner wall of the fixed cylinder, a mixing tank three is fixedly connected to the inner wall of the bottom end of the fixed cylinder, and a dispensing mechanism for opening and closing is provided at the bottom of the mixing tank one, mixing tank two and mixing tank three. Both mixing tank 1 and mixing tank 2 have fixed blocks fixedly connected to their sides. The bottom of each fixed block has a spring and a telescopic rod fixedly connected to its bottom. The inside of each fixed block has a telescopic groove. The bottom end of the spring is fixedly connected to the bottom of the inner wall of the telescopic groove. The bottom end of the telescopic rod is slidably connected to the bottom of the telescopic groove. The bottom of mixing tank 1 and mixing tank 2 are respectively fixedly connected to baffle 1 and baffle 2. Both baffle 1 and baffle 2 have feed grooves on their sides. The inner sides of baffle 1 and baffle 2 are slidably connected to the outer sides of mixing tank 2 and mixing tank 3, respectively.

[0006] Preferably, the stirring mechanism includes a motor and a rotating shaft, the bottom of the motor's drive shaft is fixedly connected to the top of the rotating shaft, the top of the rotating shaft is rotatably connected through the top of the fixed cylinder, and a stirring rod is fixedly connected to the surface of the rotating shaft.

[0007] Preferably, the feeding mechanism includes a first opening plate and a second opening plate. The bottom of the first mixing tank, the second mixing tank, and the third mixing tank are all provided with a movable groove and a feeding groove. The movable groove and the feeding groove are connected. An electric moving wheel is fixedly connected to the bottom of the inner wall of the movable groove. The bottom of the first opening plate and the second opening plate are both fixedly connected to a moving track. The moving track is rotatably connected to the roller of the electric moving wheel.

[0008] Preferably, the feeding mechanism includes a feeding bucket, a second feeding pipe, and a first feeding pipe. The top ends of the first and second feeding pipes are fixedly connected to the bottom of the feeding bucket, and the bottom ends of the first and second feeding pipes are fixedly connected to the side of the fixed cylinder. The side of the bottom end of the first feeding pipe is in contact with the outer side of the first baffle, and the side of the bottom end of the second feeding pipe is in contact with the outer side of the second baffle.

[0009] Preferably, a scraper is fixedly connected to the surface of the rotating shaft, and the bottoms of the three scrapers are slidably connected to the bottoms of the inner walls of mixing tank one, mixing tank two, and mixing tank three, respectively.

[0010] Preferably, the side of the fixed cylinder is fixedly connected with a support foot.

[0011] Preferably, both sides of the feeding hopper are fixedly connected to reinforcing plates, and the bottom end of the reinforcing plate is fixedly connected to the surface of the fixed cylinder.

[0012] Preferably, a fixing frame is fixedly connected to both sides of the motor, and the bottom of the fixing frame is fixedly connected to the top of the fixing cylinder.

[0013] Compared with the prior art, the beneficial effects of this utility model are:

[0014] This invention, by setting up mixing tank one, mixing tank two, and mixing tank three, and with the assistance of feeding pipe one, feeding pipe two, baffle one, and baffle two, can maintain a sealed environment throughout the entire drug mixing process, thereby reducing the introduction of contamination during the mixing process and enabling equal incremental mixing operations, thus ensuring the quality of the finished drug mixture. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0016] Figure 2 This is a schematic diagram of the overall structure of this utility model after being disassembled.

[0017] Figure 3 This utility model Figure 2 Enlarged schematic diagram of the structure at point A in the middle;

[0018] Figure 4 This is a schematic diagram of the rear side split section of the internal structure of the fixed cylinder of this utility model rotated 180 degrees.

[0019] Figure 5 This utility model Figure 4 Enlarged schematic diagram of the structure at point B;

[0020] Figure 6 This is a side view of the overall structure of this utility model rotated 60 degrees.

[0021] Figure 7 This is a schematic cross-sectional view of the structure at the fixed cylinder of this utility model rotated 45 degrees.

[0022] In the diagram: 1. Feeding bucket; 2. Reinforcing plate; 3. Discharge pipe two; 4. Feeding pipe; 5. Motor; 6. Fixing frame; 7. Fixing cylinder; 8. Support leg; 9. Baffle one; 10. Mixing bucket two; 11. Baffle two; 12. Mixing bucket three; 13. Rotating shaft; 14. Stirring rod; 15. Scraper; 16. Moving track; 17. Spring; 18. Mixing bucket one; 19. Fixing block; 20. Telescopic rod; 21. Opening and closing plate one; 22. Opening and closing plate two; 23. Electric moving wheel; 24. Discharge pipe one. Detailed Implementation

[0023] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0024] Please see Figures 1-7This utility model provides a technical solution: a donepezil hydrochloride tablet equal-volume addition mixing device, including a fixed cylinder 7, a feeding mechanism for adding materials is provided on one side of the fixed cylinder 7, a feeding pipe 4 is fixedly connected through the top of the fixed cylinder 7, a stirring mechanism for mixing is provided inside the fixed cylinder 7, a mixing tank 18 and a mixing tank 2 slidably connected to the inner wall of the fixed cylinder 7, a mixing tank 3 12 is fixedly connected to the inner wall of the bottom end of the fixed cylinder 7, a discharging mechanism for opening and closing is provided at the bottom of the mixing tank 18, the mixing tank 2 10 and the mixing tank 3 12, and a fixing block 19 is fixedly connected to the side of the mixing tank 18 and the mixing tank 2 10. A spring 17 and a telescopic rod 20 are fixedly connected to the bottom of the fixed block 19. A telescopic groove is opened inside the side of the fixed cylinder 7. The bottom end of the spring 17 is fixedly connected to the bottom of the inner wall of the telescopic groove. The bottom end of the telescopic rod 20 is slidably connected to the bottom of the telescopic groove. Baffle 1 9 and Baffle 2 11 are fixedly connected to the bottom of the mixing tank 1 18 and the mixing tank 2 10, respectively. A feed groove is opened on the side of both Baffle 1 9 and Baffle 2 11. By adding auxiliary materials in stages, the sealing of the mixing process can be ensured, and the mixing quality can be stabilized. The inner sides of Baffle 1 9 and Baffle 2 11 are slidably connected to the outer sides of the mixing tank 2 10 and the mixing tank 3 12, respectively.

[0025] Furthermore, the stirring mechanism includes a motor 5 and a rotating shaft 13. The bottom of the drive shaft of the motor 5 is fixedly connected to the top of the rotating shaft 13, and the top of the rotating shaft 13 is rotatably connected to the top of the fixed cylinder 7. A stirring rod 14 is fixedly connected to the surface of the rotating shaft 13, which can perform a good mixing operation on the raw materials.

[0026] Furthermore, the feeding mechanism includes a first opening plate 21 and a second opening plate 22. The bottoms of the first mixing tank 18, the second mixing tank 10, and the third mixing tank 12 are all provided with a movable groove and a feeding groove. The movable groove and the feeding groove are connected. The bottom of the inner wall of the movable groove is fixedly connected with an electric moving wheel 23. The bottoms of the first opening plate 21 and the second opening plate 22 are both fixedly connected with a moving rail 16 to facilitate the discharge of raw materials. The moving rail 16 is rotatably connected to the roller of the electric moving wheel 23.

[0027] Furthermore, the feeding mechanism includes a feeding barrel 1, a second feeding pipe 3, and a first feeding pipe 24. The top ends of the first feeding pipe 24 and the second feeding pipe 3 are fixedly connected to the bottom of the feeding barrel 1, and the bottom ends of the first feeding pipe 24 and the second feeding pipe 3 are fixedly connected to the side of the fixed cylinder 7, which allows for the addition of auxiliary materials in advance. The side of the bottom end of the first feeding pipe 24 is in contact with the outer side of the first baffle 9, and the side of the bottom end of the second feeding pipe 3 is in contact with the outer side of the second baffle 11.

[0028] Furthermore, a scraper 15 is fixedly connected to the surface of the rotating shaft 13 to facilitate scraping and exporting of raw materials, thereby reducing the amount of raw materials remaining. The bottoms of the three scrapers 15 are slidably connected to the bottoms of the inner walls of mixing tank 18, mixing tank 2 10, and mixing tank 3 12, respectively.

[0029] Furthermore, the side of the fixed cylinder 7 is fixedly connected with support feet 8, which improves the stability of the fixed cylinder 7 and facilitates the material feeding operation of the mixing tank 3 12.

[0030] Furthermore, reinforcing plates 2 are fixedly connected to both sides of the feeding barrel 1, and the bottom end of the reinforcing plates 2 is fixedly connected to the surface of the fixed cylinder 7, which further improves the stability of the feeding barrel 1.

[0031] Furthermore, a fixing bracket 6 is fixedly connected to both sides of the motor 5, and the bottom of the fixing bracket 6 is fixedly connected to the top of the fixing cylinder 7, which can further improve the stability of the motor 5.

[0032] Working principle: First, pour the required auxiliary materials into the feeding tank 1. After adding, close the lid of the feeding tank 1 to reduce the possibility of contamination of the auxiliary materials. Then, mix the main materials and auxiliary materials in a 1:1 ratio and pour them into the mixing tank 18 through the feeding pipe 4. After pouring, close the pipe cover of the feeding pipe 4. Then, start the motor 5. The motor 5 mixes the main materials and auxiliary materials through the stirring rod 14. When the main materials and auxiliary materials are added into the mixing tank 18, the weight inside the mixing tank 18 increases. As a result, the mixing tank 18 compresses the telescopic rod 20 through the fixing block 19. At this time, the mixing tank 18 drives the baffle 9 to move downward, so that the feed chute on the side of the baffle 9 corresponds to the discharge pipe 24. Through the discharge pipe 24 and the feeding tank 1, the mixing tank 20 can be pre-filled. When the weight of the raw materials in the mixing tank 18 increases, it is necessary to... To facilitate the downward feeding of subsequent materials, as the baffle 9 moves downward, its side gradually blocks the feed pipe 24, thus stopping the addition of auxiliary materials. After the raw materials in the mixing tank 18 are mixed, the electric moving wheel 23 at the bottom of the mixing tank 18 is activated. The electric moving wheel 23 uses friction to drive the opening and closing plate 21 to rotate through the moving track 16, thereby opening the feed trough of the mixing tank 18. When the raw materials are fed from the mixing tank 18 into the mixing tank 20, the mass inside the mixing tank 18 is reduced. Under the action of the spring 17, the mixing tank 18 drives the baffle 9 to move upward. After the feed pipe 24 resumes feeding, it moves upward again with the baffle 9. When the feed pipe 24 leaves the feed trough, the supply of auxiliary materials stops. At this time, the raw materials are mixed in the mixing tank 20.

[0033] The mixing situation inside the mixing tank 3 12 is the same as above. When the mixing tank 2 10 is being filled, the auxiliary materials are added through the feeding pipe 2 3 and the feeding tank 1 from the feeding trough on the side of the baffle 2 11. After the raw materials are mixed, the mixed raw materials can be discharged by opening the opening and closing plate 22 at the bottom of the mixing tank 3 12.

[0034] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0035] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A device for the incremental mixing of donepezil hydrochloride tablets, comprising a fixed cylinder (7), characterized in that: A feeding mechanism for adding materials is provided on one side of the fixed cylinder (7). A feeding pipe (4) is fixedly connected through the top of the fixed cylinder (7). A stirring mechanism for mixing is provided inside the fixed cylinder (7). A mixing tank one (18) and a mixing tank two (10) are slidably connected to the inner wall of the fixed cylinder (7). A mixing tank three (12) is fixedly connected to the inner wall of the bottom end of the fixed cylinder (7). A feeding mechanism for opening and closing is provided at the bottom of the mixing tank one (18), the mixing tank two (10), and the mixing tank three (12). A fixing block (19) is fixedly connected to the side of the mixing tank one (18) and the mixing tank two (10). A spring (17) and a telescopic rod (20) are fixedly connected to the bottom of the fixed block (19). A telescopic groove is provided inside the side of the fixed cylinder (7). The bottom end of the spring (17) is fixedly connected to the bottom of the inner wall of the telescopic groove. The bottom end of the telescopic rod (20) is slidably connected to the bottom of the telescopic groove. The bottom of the mixing tank one (18) and the mixing tank two (10) are respectively fixedly connected to the bottom of the baffle one (9) and the baffle two (11). The sides of the baffle one (9) and the baffle two (11) are provided with feed grooves. The inner sides of the baffle one (9) and the baffle two (11) are slidably connected to the outer sides of the mixing tank two (10) and the mixing tank three (12).

2. The donepezil hydrochloride tablet equal-volume addition mixing device according to claim 1, characterized in that: The stirring mechanism includes a motor (5) and a rotating shaft (13). The bottom of the drive shaft of the motor (5) is fixedly connected to the top of the rotating shaft (13). The top of the rotating shaft (13) is rotatably connected to the top of the fixed cylinder (7). A stirring rod (14) is fixedly connected to the surface of the rotating shaft (13).

3. The donepezil hydrochloride tablet equal-volume addition mixing device according to claim 1, characterized in that: The feeding mechanism includes a first opening plate (21) and a second opening plate (22). The bottom of the first mixing tank (18), the second mixing tank (10), and the third mixing tank (12) are all provided with a movable groove and a feeding groove. The movable groove and the feeding groove are connected. The bottom of the inner wall of the movable groove is fixedly connected with an electric moving wheel (23). The bottom of the first opening plate (21) and the second opening plate (22) are both fixedly connected with a moving track (16). The moving track (16) is rotatably connected to the roller of the electric moving wheel (23).

4. The donepezil hydrochloride tablet equal-volume addition mixing device according to claim 1, characterized in that: The feeding mechanism includes a feeding barrel (1), a second feeding pipe (3) and a first feeding pipe (24). The top ends of the first feeding pipe (24) and the second feeding pipe (3) are fixedly connected to the bottom of the feeding barrel (1). The bottom ends of the first feeding pipe (24) and the second feeding pipe (3) are fixedly connected to the side of the fixed cylinder (7). The side of the bottom end of the first feeding pipe (24) is in contact with the outer side of the first baffle (9). The side of the bottom end of the second feeding pipe (3) is in contact with the outer side of the second baffle (11).

5. The donepezil hydrochloride tablet equal-volume addition mixing device according to claim 2, characterized in that: The surface of the rotating shaft (13) is fixedly connected with scrapers (15), and the bottoms of the three scrapers (15) are slidably connected to the bottoms of the inner walls of mixing tank one (18), mixing tank two (10) and mixing tank three (12), respectively.

6. The donepezil hydrochloride tablet equal-volume addition mixing device according to claim 1, characterized in that: The side of the fixed cylinder (7) is fixedly connected to a support foot (8).

7. The donepezil hydrochloride tablet equal-volume addition mixing device according to claim 4, characterized in that: The feeding bucket (1) is fixedly connected to both sides with reinforcing plates (2), and the bottom end of the reinforcing plates (2) is fixedly connected to the surface of the fixed cylinder (7).

8. The donepezil hydrochloride tablet equal-volume addition mixing device according to claim 2, characterized in that: The motor (5) is fixedly connected to two sides by a fixing frame (6), and the bottom of the fixing frame (6) is fixedly connected to the top of the fixing cylinder (7).

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