Natural substance composition for the topical treatment and care of psoriatic skin and other skin diseases

Abstract

Composition of natural substances consisting of peanut oil, olive oil, castor oil and lanolin and optionally one or more representatives selected from the group consisting of avocado oil, rose oil, rose hydrolate and phytosterol.

Description

[0001] Psoriasis is a chronic, inflammatory, non-infectious skin disease.

[0002] The epidermis, which in healthy people normally renews itself in a regular cycle of approximately 26-28 days, continuously sheds aged and thus keratinized skin cells during the process. This renewal process is disrupted in psoriasis patients, resulting in a greatly accelerated renewal reaction of the epidermis, manifesting as sharply defined, reddened, raised areas of skin (so-called plaques) that may be covered by a scaly, sometimes silvery, scale layer. The joints (e.g., elbows, knees), scalp, and genital area are most commonly affected, but skin appendages such as fingernails or toenails may also exhibit psoriatic damage. Psoriasis is often associated with concurrent diseases such as arthritis or cardiovascular disease.

[0003] Overall, the course and occurrence of so-called "flare-ups" in psoriasis patients depend on many factors. Studies have shown that genetic predispositions play a role, but external conditions can also have a strong influence, such as infections, stress, diet, weather conditions, or additional medications. The pathological situation of psoriasis patients is complex and associated with particularly severe psychological stress. Because the skin is perceived by others as an externally visible organ of the body and thus represents an important means of communication, a visible skin disease such as psoriasis often leads to unjustified rejection and exclusion. This places a psychological strain on most psoriasis patients. Consistent treatment of externally visible symptoms is therefore essential.In addition to systemic treatment, various light or electrotherapy options are available. However, topical treatment of psoriatic skin is particularly important.

[0004] Known compositions for the topical treatment and care of psoriatic skin contain, for example, cortisone, the antiseptically effective dithranol (anthralin) (as in DE 32 39 203), cell proliferation-inhibiting vitamin D derivatives such as calcipotriol or calcitriol (as in WO2008 / 065514, EP2515865, or WO2012 / 127037), or salicylic acid and urea as keratolytics. However, these agents cause intolerance in many patients and / or, due to their mode of action, are only to be used after medical consultation and are limited to local application to the affected areas.

[0005] Products containing the aforementioned substances often only provide temporary symptom relief. Psoriasis patients must adhere to precise dosages for these treatments and must only apply the products to the affected areas. Treatment with cortisone-containing products can cause the skin to become thin and brittle, which is particularly detrimental for psoriasis patients already suffering from the condition. Products containing dithranol can lead to discoloration, reddening, and additional itching, so they often need to be washed off after a certain amount of time. Products containing coal tar increase the skin's sensitivity to UV rays and are suspected of causing cancer.

[0006] WO2011 / 016812A1 discloses a composition for treating psoriasis, comprising a) a mixture of oils selected from chia oil, cod liver oil, castor oil, peanut oil, and olive oil, b) pure wax and lanolin, c) metallic iodine, camphor, and benzoic acid as antiseptics, d) chlorophyll and / or herbal extracts, and e) a pharmaceutically acceptable carrier. This composition contains synthetic components and is therefore not a composition of natural substances containing exclusively naturally occurring plant or animal substances that are unprocessed or merely obtained by mechanical or water-based extraction methods. Metallic iodine is a gray-black, metallic-lustrous solid at room temperature that causes skin discoloration and can lead to allergens.Camphor can also cause discoloration, redness, and additional itching of the skin, so this composition is associated with side effects.

[0007] Psoriasis patients are therefore often skeptical of such active ingredients and seek alternatives that are easier to use in long-term treatment and do not have the side effects mentioned above. They are particularly attentive and critical of the ingredients in products for the care and treatment of psoriatic skin. Patients in high-risk groups, such as children or pregnant women, who require special caution when taking medication, in particular, require alternative treatment options.

[0008] For some time now, experts have therefore begun to produce products for the care and treatment of psoriatic skin based on natural substances. Natural substances encompass all chemical compounds formed by organisms to fulfill a biological function. Due to their often high structural diversity, natural substances are difficult to produce fully synthetically, so they are usually obtained as extracts from plant or animal components. The biomolecules contained in natural substances include biologically active substances that play an important role, especially in pharmaceuticals.

[0009] For example, EP 3 013 423 B1 discloses a composition based on oils and waxes, with an oily extract of nettle (Oleum coctus urticae). The product is used, among other things, for the treatment of psoriasis.

[0010] EP 2 489 358 B1 lists the natural substance indirubin from Indigo naturalis, also obtained by oil extraction, for the treatment of psoriasis. Here, too, plant oils are preferred.

[0011] EP 1 267 900 B1 also mentions a natural substance, betulin, which essentially comprises triterpenes, which is processed in the form of an emulsion to be applied to psoriatic skin.

[0012] Even though the aforementioned products based on natural substances have a higher acceptance among patients than conventional medications for the treatment of psoriatic skin, there are still disadvantages in their production and application.

[0013] These natural substances are extracted using complex processes and then further processed into specific dosage forms, usually as skin oils or emulsions. In some cases, such as the active ingredient betulin, solvents must be used. The manufacturing processes for these products are therefore complex and costly.

[0014] Even though these are natural substances, unwanted side effects cannot always be ruled out. For example, intolerances or overreactions to nettle are known. Even though processes for producing indirubin-containing products that reduce the skin coloration caused by indirubin are already known, the substance still stains the skin. Patients who are already psychologically stressed due to the visible skin disease therefore shy away from this type of product.

[0015] The present invention is therefore based on the object of providing a composition for the treatment and care of psoriatic skin made from natural substances, which is also referred to as a natural substance composition, which can be applied to the skin with little risk for as many affected patients as possible, is well tolerated due to the lack of side effects, leads to the complete healing of psoriatic skin and can nevertheless be produced with low costs and production expenditure.

[0016] The object of the invention is achieved by a composition of natural substances (or natural substance composition) according to claim 1, which comprises peanut oil (Arachis hypogaea), olive oil (Oleum olivarum), castor oil (Ricinus communis), lanolin and optionally one or more representatives selected from the group consisting of avocado oil (Persea gratissima), rose oil (Rosa damascena), rose hydrolate and phytosterol or consists (essentially) of the said components.

[0017] According to the invention, a "composition of natural substances" comprises or consists (essentially) exclusively of naturally occurring plant or animal substances that are unprocessed or are obtained solely by mechanical or water-based extraction methods (flotation, extraction with water, steam distillation, etc.). The mixture of at least peanut oil, olive oil, castor oil and lanolin, and optionally rose oil and / or rose hydrolate and / or lanolin and / or phytosterol contained in the composition according to the invention therefore comprises or consists (essentially) exclusively of substances obtained in the above-mentioned manner. The composition according to the invention is therefore entirely of natural origin, i.e., it contains no components of synthetic or artificial origin.

[0018] The composition according to the invention consists predominantly of plant oils, which, when mixed with lanolin, exhibit a highly positive effect on psoriatic skin or eczema, fresh scars, stretch marks, dry skin, rashes, and skin damaged by itching or sunburn. The calluses dissolve, and the inflamed, reddened skin is soothed. The mixture according to the invention is particularly well-tolerated, exhibits no side effects, and can therefore be applied externally without concern by all patient groups. With regular application, e.g., two or three times daily, the clinical picture improves significantly. In particular, skin inflammation significantly reduces. With regular application, the composition according to the invention can also lead to the complete healing of psoriatic skin.For complete healing, two to three times daily administration is recommended for a period of at least one to three months.

[0019] Patients suffering from psoriasis or eczema, fresh scars, stretch marks, dry skin, itching, skin rashes and sunburn, who belong to special risk groups, such as children and pregnant women, can also safely use the composition according to the invention.

[0020] The composition according to the invention has the advantage that it does not discolor the skin, as is the case with other agents known in the treatment of psoriasis, for example agents containing indigo or iodine (see WO2011 / 016812A1).

[0021] The use of a small number of ingredients in the composition according to the invention has the advantage of allowing the patient to quickly gain an overview of the ingredients. This also significantly limits the risk of allergy.

[0022] Ultimately, the composition according to the invention can be produced using simple equipment. Furthermore, the production costs are low.

[0023] The composition according to the invention preferably contains or consists (essentially) of peanut oil, olive oil, castor oil, and lanolin. The composition according to the invention preferably contains or consists (essentially) of peanut oil, olive oil, castor oil, and lanolin in the following concentrations: peanut oil 50-60 vol.%, olive oil 25-35 vol.%, castor oil 8-14 vol.%, and lanolin 1-4 vol.%. The actually selected concentrations add up to 100 vol.% (percent by volume).

[0024] "Peanut oil" is a vegetable oil pressed from the seeds of the peanut (Arachis hypogaea). Due to the presence of peanut oil, the composition according to the invention is not suitable for people with peanut allergies.

[0025] “Olive oil”, also called tree oil or technically oleum olivarum, is a vegetable oil obtained from the pulp and kernel of olives, the fruits of the olive tree (Olea europaea).

[0026] Castor oil is a vegetable oil obtained from the seeds of the castor oil plant (Ricinus comunis) and other members of the Euphorbisceae family, with the episperm removed from the seeds.

[0027] “Lanolin,” also known as wool wax, is the secretion from the sebaceous glands of sheep, which is obtained from sheep’s wool.

[0028] The composition according to the invention can also contain or consist (essentially) of peanut oil, olive oil, castor oil, lanolin, and rose oil. Preferably, the composition according to the invention can contain or consist (essentially) of peanut oil, olive oil, castor oil, lanolin, and rose oil in the following concentrations: peanut oil 50-60 vol.%, olive oil 25-35 vol.%, castor oil 8-14 vol.%, lanolin 1-3 vol.%, and rose oil 0.001-0.020 vol.%, whereby the selected concentrations add up to 100 vol.%.

[0029] Rose oil is extracted from rose petals (usually Rosa centifolia or Rosa damascena) by steam distillation. The rose oil, together with the other natural substances in the composition according to the invention, has a particularly positive effect on the affected skin areas.

[0030] According to a further embodiment, the composition according to the invention can also contain or (essentially) consist of peanut oil, olive oil, castor oil, lanolin and rose hydrolate, wherein the concentrations are preferably selected as follows: peanut oil 50-60 vol.%, olive oil 25-33 vol.%, castor oil 8-14 vol.%, lanolin 1-4 vol.%, and rose hydrolate 1-3 vol.%, resulting in a total of 100 vol.%.

[0031] Rose hydrosol, or rose water, is a byproduct of the distillation of rose oil from rose petals. It contains a particularly high concentration of 2-phenylethanol. Rose hydrosol has an anti-inflammatory and moisturizing effect on the skin.

[0032] A further possible embodiment of the composition according to the invention contains or consists (essentially) of peanut oil, olive oil, castor oil, avocado oil, lanolin and phytosterol, the following concentrations being preferred: peanut oil 50-60 vol.%, castor oil 25-35 vol.%, olive oil 5-12 vol.%, avocado oil 2-8 vol.%, lanolin 1-4 vol.%, and phytosterol 0.2-0.5 vol.%, the concentrations of the individual substances adding up to 100 vol.%.

[0033] Avocado oil is a vegetable oil extracted from the fruit of the avocado tree (Persea americana). Like olive oil, it is a pulp oil.

[0034] Phytosterols (or phytosterols) are secondary plant substances that contain at least 70% beta-sitosterol. According to the invention, plant phytosterol is preferably used, which is preferably present as a white solid. Pinus phytosterol (Pinus SSP), such as the phytosterol with CAS No. 949109-75-5 (PHYTOPIN®), is preferred. This phytosterol contains 70-80% beta-sitosterol, a maximum of 15% sitostanol, a maximum of 6-10% campesterol, a maximum of 2% campestanol, and a maximum of 3% other sterols.

[0035] The composition according to the invention may further comprise or consist (essentially) of peanut oil, olive oil, castor oil, avocado oil, lanolin, rose oil and phytosterol, the following concentrations being preferred: peanut oil 50-60 vol.%, castor oil 25-35 vol.%, olive oil 3-7 vol.%, avocado oil 4-8 vol.%, lanolin 2-4 vol.%, rose oil 0.01-0.02 vol.%, and phytosterol 0.2-0.5 vol.%, the selected concentrations adding up to 100 vol.%.

[0036] According to the invention, the castor oil and / or olive oil can also be in ozonized form. These oxygen-enriched oils increase the supply of oxygen to the skin, accelerating the healing of the affected areas.

[0037] The composition according to the invention can also be an ingredient of a body care product, in particular a lotion, a cream, an ointment, a washing lotion or a shampoo, as the sole active ingredient for the treatment of psoriatic skin.

[0038] Furthermore, within the scope of the invention, the composition is administered on a carrier material intended for application to the psoriatic skin to be treated, wherein the carrier material contains a specific amount of the composition according to the invention for acting on the skin to be treated. In this way, the composition according to the invention can act on the skin from the medicinal patch over a longer period of time, i.e., over several hours, which further improves the success of the treatment. Furthermore, the patient's clothing is advantageously protected, since contact with the composition can be avoided.

[0039] Five possible embodiments of the invention are listed below: Table 1: Embodiment 1 Embodiment I Ingredients Concentration vol.% Peanut oil (Arachis Hypogaea) 55,00 Castor oil (Ricinus Communis) 30,00 Olive oil (Oleum olivarum) 6,50 Avocado oil (Persea Gratissima) 6,00 lanolin 2,25 Phytosterol (plant-based) 0,25 Table 2: Embodiment 2 Embodiment II Ingredients Concentration vol.% Peanut oil (Arachis Hypogaea) 55,98 Castor oil (Ricinus Communis) 30,00 Olive oil (Oleum olivarum) 5,00 Avocado oil (Persea Gratissima) 5,75 lanolin 3,00 Rose oil (Rosa Damascena) 0, 02 Phytosterol (plant-based) 0,25 Table 3: Embodiment 3 Embodiment III Ingredients concentration vol.% Peanut oil (Arachis Hypogaea) 55,00 ozonized castor oil (Ricinus Communis) 30,00 ozonized olive oil (Olea Europaea) 10,00 lanolin 2,40 Avocado oil (Persea Gratissima) 2,35 Phytosterol (plant-based) 0,25 Table 4: Embodiment 4 Embodiment IV Ingredients Concentration vol.% Peanut oil (Arachis Hypogaea) 55,98 Olive oil (Oleum olivarum) 30,00 Castor oil (Ricinus Communis) 12,00 lanolin 2,00 Rose oil (Rosa Damascena) 0, 02 Table 5: Embodiment 5 Embodiment V Ingredients Concentration vol.% Peanut oil (Arachis Hypogaea) 55,0 Olive oil (Oleum olivarum) 28,0 Castor oil (Ricinus Communis) 10,5 lanolin 3,0 rose water 1,5 Table 6: Embodiment 6 Embodiment VI Ingredients concentration vol.% Peanut oil (Arachis Hypogaea) 54,98 ozonized castor oil (Ricinus Communis) 30,00 ozonized olive oil (Olea Europaea) 10,00 lanolin 2,40 Avocado oil (Persea Gratissima) 2,35 Phytosterol (plant-based) 0,25 Rose oil (Rosa damascena) 0, 02

[0040] The natural substance composition according to the invention can be stored at room temperature for 20 to 24 months. Consequently, the natural substance composition according to the invention is stable at room temperature for 20 to 24 months.

[0041] The natural substance composition according to the invention can preferably be in the form of an oil, e.g., a pale yellow oil. This has the advantage that it easily penetrates the skin to be treated and preferably does not cause any discoloration of the skin. Alternatively, the natural substance composition according to the invention can also be in the form of a cream, gel, lotion, or paste. It is particularly preferably in the form of an oil. The above-mentioned compositions can advantageously be prepared with little effort. The individual oils are mixed together one after the other and heated to 56-58°C. Lanolin and, if appropriate, phytosterol are then added and dissolved. Alternatively, the peanut oil, if appropriate, is mixed with the phytosterol and heated to 50 to a maximum of 75°C.Olive oil, castor oil, and optionally one or more representatives selected from the group consisting of avocado oil, rose oil, and rose hydrolate are then added together with lanolin and the resulting mixture is cooled.

[0042] The effect of the compositions according to the invention in the above-mentioned embodiments has already been successfully tested on several patients. The test subjects were all affected by psoriasis type I. Within 8 to 10 weeks of consistent treatment with the composition according to the invention, the plaques in all patients had, in a preferred embodiment, significantly reduced and in some cases even healed completely. According to the invention, “consistent treatment” comprises the patient applying the composition according to the invention in a thin layer (i.e. a few drops) to the affected area at least twice a day (e.g. morning and evening), rubbing it in and waiting until it is completely absorbed, which can take about 15 to 20 minutes. Likewise, the composition according to the invention can be applied in a thin layer to the affected area three times a day (e.g. morning, midday and evening).This application can provide immediate relief, especially from itching.

[0043] The effect of the composition according to the invention is explained below using examples. Example 1:

[0044] The patient, 19 years old, suffers from type I psoriasis on her arm and thigh, as well as psoriasis capitis on her scalp. The plaques on her thigh and arm were treated with the composition according to the invention (Embodiment 4). The test treatment began on January 15, 2018, and ended on March 29, 2018. The composition was applied to the affected areas in the morning and evening. The areas were covered with a plaster to allow the composition to penetrate the skin even under clothing. Fig. 1 - 5 show the healing process of the affected skin area on the thigh.

[0045] This shows Fig. 1 the treated skin area on day 1 of treatment, Fig. 2 the treated skin area on day 30 of treatment, Fig. 3 the treated skin area on day 62 of treatment, Fig. 4 the treated skin area on day 72 of treatment, and Fig. 5 the treated skin area on day 75 of treatment. Example 2:

[0046] A monocentric, clinical-dermatological application study was conducted with the composition according to the invention according to embodiment II and with 20 subjects and twice daily application on the acute eczema caused by psoriasis over a period of 8 weeks.

[0047] The primary study objectives were to test skin tolerability (from the start of the study to the end of the study and for 30 days thereafter, all skin reactions and other possible side effects were recorded in the reaction form). Secondary study objectives were to test efficacy via dermatological assessment (measurement times: 4 Wochen and T 8 Wochen ).

[0048] The inclusion criteria were: 18 years and older, female and male subjects with healthy skin, any skin type, subjects with acute eczema in psoriasis (not requiring medical treatment), written informed consent from the subjects or their legal guardians was available.

[0049] The exclusion criteria were: severe or chronic skin inflammation, serious internal or chronic diseases, taking medications that can affect the skin reaction (glucocorticoids, antiallergics, topical immunomodulators, etc.), application of preparations and care products containing active ingredients 7-10 days before the start of the test, severe allergies or ever occurring serious side effects from cosmetic products, sunbathing or visits to the solarium during the study, known cancer, and pregnancy / breastfeeding. Dermatological examination results:

[0050] The studies were conducted according to clinical-dermatological assessment criteria. Twenty test subjects demonstrated healthy skin in the test area before, during, and after the application study. No pathological skin changes of any kind were observed. No interruptions to the test or even dermatological treatment were performed. The composition according to the invention was very well tolerated by these subjects and did not lead to any dermatologically relevant skin changes.

[0051] After 14 days of use, one volunteer reported a painful burning sensation on both elbows after applying cream to the skin affected by psoriasis. Upon examination, the skin area was also slightly irritated and slightly red. The skin on the acute psoriasis eczema was intact upon examination. The volunteer did not have a nut allergy. The volunteer discontinued the study. The symptoms of the psoriasis eczema completely subsided after approximately four days, and medical treatment was not required. Dermatological assessment: Tab. 6: Intensities of the redness parameter in the test area before testing and after 8 weeks Subject No. . T 0 T 8 Wochen difference Change [%] 1 8,0 7,0 -1,0 -12,5 2 10,0 10,0 0,0 0,0 3 6,0 2,0 -4,0 -66,7 4 7,0 7,0 0,0 0,0 5 4,0 and and and 6 8,0 5,0 -3,0 -37,5 7 10,0 8,0 -2,0 -20,0 8 9,0 5,0 -4,0 -44,4 9 4,0 4,0 0,0 0,0 10 6,0 7,0 1,0 16,7 11 6,0 6,0 0,0 0,0 12 5,0 4,0 -1,0 -20,0 13 7,0 4,0 -3,0 -42,9 14 8,0 7,0 -1,0 -12,5 15 4,0 3,0 -1,0 -25,0 16 6.0 8.0 2.0 33,3 17 8.0 5,0 -3,0 -37,5 18 8,0 0,0 -8,0 -100,0 19 8,0 6,0 -2.0 -25.0 20 8,0 7,0 -1,0 -12,5 21 8,0 6,0 -2,0 -25,0 Average 7,0 5,6 -1,4 -20,0 minimum 4,0 0,0 -8,0 -100,0 maximum 10,0 10,0 2,0 33,3 Stand. dev. 1,8 2,3. 2,2 19,3 Tab.7: Intensities of the parameter scaling in the test area before testing and after 8 weeks Subject No. . T 0 T 8 Wochen difference Change [%] 1 8,0 4,0 -4,0 -50,0 2 5,0 3,0 -2,0 -40,0 3 5,0 2,0 -3,0 -60,0 4 8,0 5,0 -3,0 -37,5 5 9,0 and and and 6 4,0 2,0 -2,0 -50,0 7 10,0 6,0 -4,0 -40,0 8 7,0 2,0 -5,0 -71,4 9 7,0 3,0 -4,0 -57,1 10 7,0 3,0 -4,0 -57,1 11 6,0 4,0 -2,0 -33,3 12 7,0 3,0 -4,0 -57,1 13 3,13 1,0 -2,0 -66,7 14 5,0 2,0 -3,0 -60,0 15 4,0 2,0 -2,0 -50,0 16 10,0 10,0 0,0 0,0 17 6,0 3,0 -3,0 -50,0 18 6,0 1.0 -5,0 -83,3 19 7,0 5.0 -2,0 -28,6 20 3,0 3,0 0,0 0,0 21 8,0 7,0 -1,0 -12,5 Average 6,4 3,6 -2,8 -43,8 minimum 3,0 1,0 -5,0 -83,3 maximum 10,0 10,0 0,0 0,0 Stand. dev. 2,0 2,2 1,4 22,1 Tab. 8: Intensities of the parameter lichenification (increase, thickening of the skin in the area of ​​acute eczema) in the test area before testing and after 8 weeks Subject No. . T 0 T 8 Wochen difference Change [%] 1 10,0 8,0 -2,0 -20,0 2 10,0 8,0 -2,0 -20,0 3 6,0 3,0 -3,0 -50,0 4 8.0 6,0 -2,0 -25,0 5 7,0 and and and 6 7,0 4,0 -3,0 -42,9 7 10,0 5,0 -5,0 -50,0 8 7,0 3,0 -4,0 -57,1 9 6,0 4,0 -2,0 -33,3 10 6,0 4,0 -2,0 -33,3 11 5,0 5,0 0,0 0,0 12 6,0 4,0 -2,0 -33,3 13 3,0 1,0 -2,0 -66,7 14 4,0 2,0 -2,0 -50,0 15 7,0 2,0 -5,0 -71,4 16 10,0 10.0 0,0 0,0 17 6,0 4,0 -2,0 -33,3 18 7,0 1.0 -6,0 -85,7 19 2,0 2,0 0,0 0,0 20 7,0 6,0 -1,0 -14,3 8,0 5,0 -3,0 -37,5 Average 6,8 4.4 -2,4 -36,2 minimum 2,0 1,0 -6,0 -85,7 maximum 10,0 10,0 0,0 0,0 Stand. dev. 2,2 2,4 1,6 23,8 Assessment of study results:Skin compatibility:

[0052] The composition according to the invention was applied twice daily for a period of eight weeks by 20 volunteers, primarily on acute psoriasis-induced eczema. From a clinical-dermatological perspective, no relevant skin reactions occurred in the test area; the composition according to the invention was very well tolerated. Neither intolerance reactions in the sense of irritation nor allergic reactions (contact dermatitis) were observed. One volunteer reported a painful burning sensation on both elbows after applying cream to the skin affected by psoriasis after 14 days of use. During examination, the skin area was also slightly irritated and slightly reddened. The volunteer does not have a nut allergy. The skin on the acute psoriasis eczema was intact during examination. The symptoms of the psoriasis eczema completely subsided after approximately four days, and medical treatment was not required. Effectiveness:

[0053] The efficacy of the composition according to the invention with respect to the symptoms of psoriasis: redness, scaling, and lichenification (elevation of the skin in the area of ​​acute eczema) was determined using a dermatological assessment. A reduction in redness of -20.0%, scaling of -43.8%, and lichenification (elevation of the skin in the area of ​​acute eczema) of -36.2% was demonstrated in the test area. QUOTES CONTAINED IN THE DESCRIPTION

[0000] This list of documents submitted by the applicant was generated automatically and is included solely for the convenience of the reader. This list is not part of the German patent or utility model application. The DPMA assumes no liability for any errors or omissions. Cited patent literature

[0000] DE 32 39 203

[0004] WO 2008 / 065514

[0004] EP 2515865

[0004] WO 2012 / 127037

[0004] WO 2011 / 016812A1 [0006, 0020] EP 3 013 423 B1

[0009] EP 2 489 358 B1

[0010] EP 1 267 900 B1

[0011]

Claims

[1] Composition of natural substances, consisting of peanut oil, olive oil, castor oil and lanolin and optionally one or more representatives selected from the group consisting of avocado oil, rose oil, rose hydrolate and phytosterol. [2] Composition according to claim 1, characterized by that they (i) consists of peanut oil, olive oil, castor oil and lanolin, containing peanut oil, olive oil, castor oil and lanolin in the following concentrations: -Peanut oil 50-60 vol.%, -olive oil 25-35 vol.%, -Castor oil 8-14 vol.%, as well as -Lanolin 1-4 vol.%, where the selected concentrations add up to 100 vol.%; or (ii) consists of peanut oil, olive oil, castor oil, lanolin and rose oil, containing peanut oil, olive oil, castor oil, lanolin and rose oil in the following concentrations: -Peanut oil 50-60 vol.%, -olive oil 25-35 vol.%, -Castor oil 8-14 vol.%, -Lanolin 1-3 vol.%, as well as -Rose oil 0.001-0.020 vol.%, where the selected concentrations add up to 100 vol.%; or (iii) consists of peanut oil, olive oil, castor oil, lanolin and rose hydrolate, containing peanut oil, olive oil, castor oil, lanolin and rose hydrolate in the following concentrations: -Peanut oil 50-60 vol.%, - Olive oil 25-33 vol.%, - Castor oil 8-14 vol.%, - Lanolin 1-4 vol.%, as well as - Rose hydrolate 1-3 vol.%, where the selected concentrations add up to 100 vol.%; or (iv) consists of peanut oil, olive oil, castor oil, avocado oil, lanolin and phytosterol, containing peanut oil, olive oil, castor oil, avocado oil, lanolin and phytosterol in the following concentrations: - Peanut oil 50-60 vol.%, - Castor oil 25-35 vol.%, - Olive oil 5-12 vol.%, - Avocado oil 2-8 vol.%, - Lanolin 1-4 vol.%, as well as - Phytosterol 0.2-0.5 vol.%, where the selected concentrations add up to 100 vol.%; or (v) consists of peanut oil, olive oil, castor oil, avocado oil, lanolin, rose oil and phytosterol, containing peanut oil, olive oil, castor oil, avocado oil, lanolin, rose oil and phytosterol in the following concentrations: -Peanut oil 50-60 vol.%, -Castor oil 25-35 vol.%, -olive oil 3-7 vol.%, -Avocado oil 4-8 vol.%, -Lanolin 2-4 vol.%, -Rose oil 0.001-0.020 vol.%, and -Phytosterol 0.2-0.5 vol.%, where the selected concentrations add up to 100 vol.%. [3] Composition according to any one of the preceding claims, characterized by that it consists of the following components: Peanut oil 55.98 vol.% castor oil 30.00 vol.% olive oil 5.00 vol.% Avocado oil 5.75 vol.% lanolin 3.00 vol.% rose oil 0.02 vol.% Phytosterol (plant-based) 0.25 vol.% [4] Composition according to any one of the preceding claims, characterized bythat it contains only naturally occurring plant or animal substances that are unprocessed or obtained solely by mechanical or water-based extraction methods. [5] Composition according to any one of the preceding claims, characterized by that the castor oil and / or olive oil are in ozonized form. [6] Composition according to any one of the preceding claims, characterized by that it is in the form of an oil, a cream, a gel, a lotion or a paste, preferably in the form of an oil. [7] Composition according to any one of the preceding claims for the topical treatment and care of psoriatic skin. [8] A composition according to claim 7, wherein the composition is applied to the skin to be treated twice or three times daily.

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