DEVICE FOR TREATING A PORTION OF TISSUE FROM A HUMAN OR AN ANIMAL

Description

Technical field

[0001] The invention relates to a device for treating a tissue section (W), in particular a wound, of a human or an animal, the device comprising an application device for applying a first composition, a second composition and a third composition for treating the tissue section to the tissue section and an exposure device for exposing the compositions applied to the tissue section to light and a carrying device, wherein the carrying device carries the at least one application opening and the exit surface. State of the art

[0002] Photodynamic therapy (PDT) is a method for treating, among other things, tumors and other tissue changes such as neovascularization using light in combination with a light-activated substance, a so-called photosensitizer, and oxygen present in the tissue. For this purpose, the patient is administered such a primarily non-toxic sensitizer or one of its metabolic precursors either systemically or locally. Due to specific properties of the tumor or tissue change, the sensitizer selectively accumulates in the tumor or tissue change. After a certain waiting period, the tumor or tissue change is irradiated with light of a suitable wavelength. Photophysical processes generate toxic substances, primarily reactive oxygen species, which damage the tumor or tissue change.

[0003] Photodynamic disinfection, also known as antibacterial photodynamic therapy (aPDT) or photoactivated disinfection, is a procedure used, among other things, in dentistry to support the treatment of bacterial infections in periodontitis (Clinical Oral Investigations (2022) 26:3005-3010 https: / / doi.org / 10.1007 / s00784-021-04282-z; Der Hautarzt (2005) 11:1048-1055 https: / / doi.org / 10.1007 / s00105-005-0977-7; Der Hautarzt (2021) 1:27-33 https: / / doi.org / 10.1007 / s00105-020-04737-6). As with photodynamic therapy, light is used in combination with a light-activated substance, a so-called photosensitizer, and existing atmospheric oxygen.

[0004] Photodynamic disinfection typically involves the following steps: a. Staining the microorganisms with a photosensitizer, b. Allowing the photosensitizer to act for a time dependent on the indication and severity of the disease, c. Rinsing and removing the excess photosensitizer, d. Exposing the photosensitizer to light at a wavelength, intensity, and exposure time dependent on the indication and severity of the disease.

[0005] The individual steps are performed using different devices, and may also need to be performed using different devices depending on the indication, for example, to enable exposure to different wavelengths. Furthermore, additional devices are usually required for further steps in wound treatment, such as stimulating wound healing. The large number of devices used makes treatment complex and error-prone. It is particularly difficult to perform all treatment steps precisely at the site of a localized wound.

[0006] In addition, known methods of photodynamic disinfection do not always lead to complete disinfection, so additional treatment with other disinfection methods is necessary, which further increases the treatment effort. Technical task

[0007] The object of the invention is to provide versatile devices for the simple and effective treatment of a tissue section, in particular a wound, of a human or an animal. Technical solution

[0008] The present invention provides a device according to claim 1 that solves the technical problem. Advantageous embodiments are the subject of the dependent claims.

[0009] The device is designed for treating a tissue section, in particular a wound, of a human or an animal. The tissue section can be, for example, a section of skin or a mucous membrane, in particular a section of oral mucosa. The wound can be an external or internal tissue injury, for example, a tissue injury in the oral cavity of a human or an animal. The tissue injury can be caused, for example, by a surgical procedure.

[0010] The device comprises an application device for applying a first composition, a second composition and a third composition for treating the tissue section to the tissue section, wherein the application device comprises at least one application opening for delivering the compositions from the application device to the tissue section.

[0011] The device comprises an exposure device for exposing the compositions applied to the tissue section to light, wherein the exposure device comprises an exit surface for the exit of the light from the exposure device.

[0012] The device comprises a support device, wherein the support device supports the at least one application opening and the exit surface. Further parts of the application device and / or the exposure device can be arranged separately from the support device so that the support device can be as small and light as possible. The parts arranged outside the support device can be connected to the support device by a number of lines, for example for conducting the compositions and / or the light. The lines are preferably flexible so that they do not hinder a person treating the tissue section and / or the accessibility of the tissue section. Beneficial effects

[0013] Because the at least one application opening and the exit surface are supported by the support device, the application and exposure can be performed using the same support device. Consequently, the treatment of the tissue section is particularly simple and can be carried out with particular local precision.

[0014] In particular, the carrying device prevents the compositions from being applied outside the treatment area. This requires a particularly small amount of the compositions, and potential side effects are avoided. Contact of a composition, particularly one according to the invention or one containing hypochlorous acid, with mucous membranes or open wounds can, for example, lead to irritation.

[0015] Furthermore, the fact that the at least one application opening and the exit surface are supported by the same support device establishes a defined positioning and orientation of the exit surface relative to the at least one application opening. This ensures that exposure occurs precisely where the compositions were applied. This enables a particularly efficient treatment, and side effects due to exposure of tissue outside the application area of ​​the compositions are avoided.

[0016] Because the application device is designed to apply a first composition, a second composition, and a third composition to the tissue section for treating the tissue section, up to three different compositions can be used with the same device, particularly simultaneously. Consequently, the effectiveness of the treatment and the versatility of the device are increased without increasing the treatment effort. Description of the execution types

[0017] The device preferably comprises a rinsing device for rinsing the tissue section with a rinsing fluid, wherein the rinsing device comprises at least one rinsing opening carried by the support device for delivering the rinsing fluid from the rinsing device to the tissue section. The at least one application opening can be identical to the at least one rinsing opening.

[0018] The device preferably comprises a suction device for sucking the rinsing fluid from the tissue section, wherein the suction device comprises at least one suction opening carried by the support device for receiving the rinsing fluid from the tissue section into the suction device.

[0019] Other parts of the rinsing device and / or the suction device, apart from the at least one rinsing opening and / or the at least one suction opening, can be arranged separately from the support device, so that the support device can be as small and light as possible. The parts arranged outside the support device can be connected to the support device by a number of lines, for example, for conducting the rinsing fluid. The lines are preferably flexible so that they do not hinder a person treating the tissue section.

[0020] Because the at least one rinsing opening and / or the at least one suction opening are also carried by the carrying device, the rinsing and / or suction can also be performed using the carrying device, making the treatment particularly simple and the device particularly versatile. Furthermore, the carrying device defines the position and orientation of the rinsing opening and / or the suction opening relative to the application opening, so that the rinsing and / or suction can be performed precisely at the site of application of the compositions, ensuring a particularly targeted and efficient treatment.

[0021] The distance between the rinsing opening and the suction opening is preferably between 1 mm and 10 mm, preferably between 1 mm and 8 mm, and particularly preferably between 1 mm and 5 mm. These distances allow for particularly efficient rinsing of the tissue section.

[0022] The application device preferably comprises a flow control unit for controlling, in particular independently of one another, a flow of each of the three compositions onto the tissue section. With the aid of the flow control unit, an optimal amount of the compositions for treatment can be applied to the tissue section in a simple and reliable manner.

[0023] The flow control unit preferably comprises a valve, particularly preferably a check valve, a pump, and / or a pressure generator, particularly preferably with a compressed gas cartridge. The check valve can advantageously prevent foreign substances from the tissue section from penetrating the application device and contaminating the compositions. The pump and the pressure generator can assist in transporting the compositions to the tissue section and thus simplify their application.

[0024] The application device preferably comprises a nebulization unit for nebulizing the first composition, the second composition, and / or the third composition during application to the tissue section. The nebulization can increase the effectiveness of the nebulized composition by increasing the surface area of ​​the composition. For example, an increased disinfecting effect was observed for an aqueous solution of hypochlorous acid (BOECKER, D., et al. Safe, Effective, and cost-efficient air cleaning for populated rooms and entire buildings based on the disinfecting power of vaporized hypochlorous acid. International Journal of Health and Medical Engineering, 2022, year 16, no. 12, pp. 209-213). The nebulization unit can, for example, be designed like the nebulization unit described in US Pat. No. 9,573,148 B2.

[0025] The application device is preferably designed to accommodate a replaceable cartridge containing the first composition, the second composition, and / or the third composition. Using the cartridge, the compositions can be particularly easily filled into the application device, refilled, and exchanged for other compositions. This makes the device particularly simple and versatile to use.

[0026] The application device preferably comprises at least one cannula, particularly preferably one cannula each, for removing the compositions from the cartridge. The cartridge can be automatically pierced with the cannula as soon as the cartridge is inserted into the application device. This allows the cartridge to be opened particularly easily and without risk of contaminating its contents. Providing a cannula for each composition prevents mixing of the compositions, which could impair their effectiveness.

[0027] The application device is preferably designed to accommodate multiple cartridges, wherein the application device preferably comprises a selection element, preferably a carousel, for selecting one of the cartridges for applying the compositions contained in the selected cartridge. This allows different compositions to be kept ready in the application device for different indications and easily selected for use in disinfection.

[0028] The device may comprise a production device for producing at least one of the compositions. The production device may, for example, be designed to produce an aqueous solution of hydrogen peroxide and / or an aqueous solution of hypochlorous acid. The production device may, for example, comprise an electrolyzer. The production device advantageously allows compositions that are not storable or can only be stored with great effort to be produced directly before their application.

[0029] The device preferably comprises a sound generator, preferably an ultrasound generator, for applying sound, preferably ultrasound, to the first composition, the second composition, and / or the third composition during application to the tissue section and / or to the rinsing fluid during rinsing of the tissue section. By applying sound, particularly ultrasound, the compositions and / or the rinsing fluid can penetrate the tissue section more quickly and deeply, thus resulting in particularly efficient and effective rinsing and / or treatment.

[0030] The exposure device preferably comprises at least one laser, preferably at least one diode laser, for generating the light. A laser has the advantage of providing a focused light beam with high intensity and a defined wavelength. A diode laser is characterized by its small size, low mass, and low energy consumption. The diode laser can, for example, be integrated into the support device. The exposure device can comprise at least one incandescent lamp, in particular at least one halogen incandescent lamp, or at least one light-emitting diode (LED) for generating the light.

[0031] The exposure device is preferably designed for exposure to light with a preferably adjustable wavelength in a range from 150 nm to 1400 nm, preferably from 400 nm to 500 nm and / or from 800 nm to 1400 nm, particularly preferably from 405 nm, 430 nm, 470 nm and / or 490 nm. The aforementioned ranges and wavelengths lead to a particularly effective treatment, in particular with hydrogen peroxide, curcumin, rose bengal and / or hypochlorous acid in the compositions. Light with a wavelength in the range from 150 nm to 600 nm can preferably be used for photodynamic disinfection. Light with a wavelength in the range from 800 nm to 1400 nm can preferably be used to stimulate wound healing.

[0032] The exposure device is preferably designed for exposure to light with a preferably adjustable intensity in a range from 5 mW / cm 2 to 500 mW / cm 2 , preferably from 50 mW / cm 2 to 150 mW / cm 2 . These ranges, particularly with hydrogen peroxide, curcumin, rose bengal, and / or hypochlorous acid in the compositions, result in a particularly effective treatment without damaging the tissue adjacent to the tissue section.

[0033] The light output is, for example, from 10 mW to 500 mW, in particular from 50 mW to 150 mW, preferably 100 mW. With these power levels, the aforementioned advantageous intensities can be achieved on an exposure area of ​​the order of 1 cm2, suitable for efficient and precise treatment of the tissue section.

[0034] The exposure device is preferably designed for exposure to light with a preprogrammed sequence of different wavelengths. A preprogrammed sequence allows for the automated activation of different absorption ranges of one or more photosensitizers to achieve a particularly effective treatment, particularly against several different microorganisms. An exemplary sequence that demonstrates particularly effective disinfection, particularly with hydrogen peroxide, rose bengal, curcumin, and / or hypochlorous acid, comprises successive exposures to light with wavelengths of 405 nm, 430 nm, 470 nm, and 490 nm for 10 minutes each.

[0035] The exposure device is preferably designed for exposure to light for a preprogrammed period of time, for example, from 1 minute to 20 minutes, preferably from 2 minutes to 15 minutes, and particularly preferably from 3 minutes to 10 minutes. A preprogrammed period of time increases the safety of the treatment by avoiding exposure that is too short, which could lead to incomplete disinfection, and exposure that is too long, which could damage tissue adjacent to the tissue section. These periods of time lead to effective and safe disinfection, particularly with hydrogen peroxide, Rose Bengal, curcumin, and / or hypochlorous acid.

[0036] The rinsing device is preferably designed to rinse the tissue section with a gaseous rinsing fluid, preferably air, and / or with a liquid rinsing fluid, preferably an aqueous solution. The aqueous solution can be a saline solution, preferably physiological saline.

[0037] The rinsing device preferably comprises a pressure generator, for example a pump, for applying a preferably adjustable overpressure to the rinsing fluid in a range from 1 bar to 80 bar above atmospheric pressure. With an overpressure in this range, the tissue section can be rinsed effectively, quickly, and gently for adjacent tissue. An adjustable overpressure has the advantage that it can be adapted to the type of infection and / or the tissue adjacent to the tissue section.

[0038] The rinsing device preferably comprises a reservoir containing the rinsing fluid. This advantageously allows the device to be operated independently of an external source of the rinsing fluid.

[0039] The flushing device preferably comprises a connection device for connecting the flushing device to an external supply line for supplying the flushing device with the flushing fluid. As a result, the flushing device does not require a storage container for the flushing fluid and can therefore be designed in a particularly space-saving manner.

[0040] The suction device preferably comprises a pump for suctioning the rinsing fluid at a preferably adjustable negative pressure of 0.1 bar to 0.8 bar, preferably from 0.1 bar to 0.3 bar, particularly preferably from 0.1 bar to 0.2 bar, below atmospheric pressure. With a negative pressure in this range, the rinsing fluid can be suctioned from the tissue section effectively, quickly, and without damaging adjacent tissue. An adjustable negative pressure has the advantage that it can be adapted to the type of infection and / or the tissue adjacent to the tissue section.

[0041] The suction device preferably includes a disposal container for collecting the suctioned rinsing fluid. This advantageously allows the device to be operated independently of an external sink for the rinsing fluid.

[0042] The suction device preferably comprises a connection device for connecting the suction device to an external disposal line for disposing of the extracted rinsing fluid. This eliminates the need for a disposal container for the rinsing fluid and allows for a particularly space-saving design.

[0043] The device preferably comprises a, preferably programmable, control device for, preferably automated, control of the rinsing device, the suction device, the application device, and / or the exposure device. The control device can cause the device to perform the individual steps of treating the tissue section automatically with parameters adapted to the type of infection and / or the tissue adjacent to the tissue section, so that the treatment can be carried out more easily and safely. Manual adjustment of individual, several, or all parameters may be possible before or during treatment.

[0044] The control device comprises, for example, a computer device communicatively connected to the rinsing device, the suction device, the application device, and / or the exposure device. The control device preferably comprises a user interface, for example a touch-sensitive screen, for interaction with the treatment person.

[0045] The carrying device is preferably designed as a handpiece that can be held with one hand by a treating person for performing the treatment. The dimensions, shape, and mass of the handpiece are preferably designed so that the treating person can perform the treatment ergonomically with the handpiece.

[0046] Because the application port and the exit surface, as well as preferably the irrigation port and / or the suction port, are integrated into the handpiece, the practitioner can perform several or even all steps of the treatment with the same handpiece. Consequently, the treatment is particularly simple and can be performed with particular local precision.

[0047] In particular, integration into the handpiece prevents the compositions from being applied outside the treatment area and prevents exposure to light outside the treatment area. This requires a particularly small amount of the compositions, preventing potential side effects.

[0048] The support device is preferably designed as a tent for accommodating the human or animal. The tent can be configured to accommodate the human or animal completely or partially; for example, the tent can be designed to accommodate one limb, two limbs, a lower body, and / or an upper body. The tent can, for example, be designed like a sauna tent. The design of the support device as a tent is particularly suitable for the efficient treatment of large tissue sections.

[0049] When the carrying device is configured as a tent, the application device can, for example, comprise a drip irrigation system, an evaporation device, and / or a nebulization device for the compositions in the tent. This allows the compositions to be efficiently applied even to large-area fabric sections.

[0050] In the design of the support device as a tent, the exposure device can comprise, for example, an LED strip and / or a number of light guides for large-area exposure of the compositions.

[0051] The carrying device is preferably designed as a breathing mask for ventilating humans or animals. Breathing masks frequently lead to infections and inflammations of the skin and mucous membranes, particularly with prolonged use. If the carrying device is designed as a breathing mask, this offers the advantage that an infection or inflammation can be treated particularly easily with the device according to the invention, without interrupting the ventilation of the human or animal.

[0052] The invention relates to a cartridge for use in a device according to the invention. The application device of the device is preferably designed to replaceably accommodate the cartridge according to the invention. The invention also relates to a device according to the invention comprising a cartridge according to the invention, wherein the cartridge is preferably replaceably accommodated by the application device of the device.

[0053] The cartridge comprises a first reservoir containing the first composition, preferably a second reservoir containing the second composition, which is fluid-tightly separated from the first reservoir, and more preferably a third reservoir containing the third composition, which is fluid-tightly separated from the first reservoir and the second reservoir. This prevents mixing of the compositions, which could lead to undesirable interactions that could impair the efficacy of the treatment. Nevertheless, only a single cartridge is required for the compositions, making procurement, storage, and replacement of the cartridge easier than if multiple cartridges were necessary.

[0054] The cartridge preferably comprises a first dispensing opening for dispensing the first composition from the first reservoir, particularly preferably a second dispensing opening for dispensing the second composition from the second reservoir, and most preferably a third dispensing opening for dispensing the third composition from the third reservoir. Separate dispensing openings prevent unwanted mixing of the compositions.

[0055] Preferably, at least one, in particular each, of the withdrawal openings is closed by a valve, particularly preferably a check valve, and / or a septum. A check valve has the advantage of preventing foreign substances from entering the associated reservoir. A septum has the advantage of reliably closing the associated withdrawal opening and can be opened easily, for example, with a cannula of the device's application device.

[0056] Preferably, at least one, in particular each, of the reservoirs of the cartridge is sealed light-tight. This allows even compositions containing light-sensitive components to be stored in the reservoir without additional protective measures.

[0057] At least one, and in particular each, of the compositions in the cartridge has an overpressure above atmospheric pressure. As a result, as soon as the cartridge is opened, the composition can be driven out of the cartridge by the overpressure and applied to the tissue section without the need for an additional drive, such as a pump. The device can therefore be designed particularly simply.

[0058] The first composition that can be applied by the device and / or contained in the cartridge preferably contains curcumin, rose bengal, 5-aminolevulinic acid, embelin, and / or methylene blue. These photosensitizers, particularly a combination of curcumin with rose bengal, allow for particularly effective disinfection of the tissue section.

[0059] The first composition that can be applied by the device and / or contained in the cartridge preferably contains chitosan nanoparticles. The addition of chitosan nanoparticles can enhance the effectiveness of the photosensitizers, particularly the aforementioned photosensitizers.

[0060] The second composition, which can be applied by the device and / or contained in the cartridge, preferably contains or is hypochlorous acid, preferably as an aqueous solution with a molar fraction of 0.01% to 1%, particularly preferably 0.04% to 0.5%. A two-stage disinfection with such a second composition and a first composition configured as described above, in particular with curcumin and rose bengal, is particularly effective.

[0061] Hypochlorous acid preferably does not contain sodium hypochlorite, as this can damage blood vessels. Hypochlorous acid is not susceptible to microbial growth due to its oxidizing properties and its low pH.

[0062] The third composition that can be applied by the device and / or contained in the cartridge contains or is, for example, an aqueous solution of chlorhexidine, in particular with a chlorhexidine concentration of 0.05% to 0.25%, preferably of 0.1% to 0.2%, particularly preferably of 0.12%.

[0063] The third composition that can be applied by the device and / or contained in the cartridge contains or is, for example, an aqueous solution of hydrogen peroxide, in particular with a hydrogen peroxide concentration of 0.5% to 10%, preferably 1% to 5%, particularly preferably 1.5% to 3.0%. Chlorhexidine and hydrogen peroxide in the stated concentrations each exhibit effective wound disinfection, which can be enhanced by light exposure.

[0064] The cartridge preferably includes a temperature indicator for indicating when a maximum storage temperature of the cartridge has been exceeded and / or when a minimum storage temperature of the cartridge has been undershot. The temperature indicator allows a person using the cartridge to easily determine whether it has been stored outside the intended temperature range, which could impair the effectiveness of the compositions. This increases the safety of using the cartridge.

[0065] The temperature indicator may, for example, contain at least one dye that changes color when the maximum storage temperature is exceeded or the minimum storage temperature is undershot.

[0066] To ensure the stability and sterility of the compositions, the cartridge should preferably be stored in the refrigerator and should not be left unopened or exposed to light for an unnecessarily long period of time during use. The effect of temperature on stability can be significant; for example, the decomposition rate of hypochlorous acid doubles between 20°C and 25°C.

[0067] The invention relates to a composition for treating a tissue section, in particular a wound, of a human or an animal using a device according to the invention. The invention also relates to a device according to the invention and a cartridge according to the invention, each comprising the composition according to the invention as the first composition.

[0068] The composition is gel-like. It is therefore a dispersed system comprising a solid and a liquid component. The solid component forms a sponge-like, three-dimensional matrix whose pores are filled with a liquid component. The liquid component is thus immobilized in the solid component. Thus, unlike a liquid composition, the gel-like composition remains where it is applied to the tissue section. This requires a particularly small amount of the composition, and possible side effects due to uncontrolled spreading of the composition are avoided. Contact of a composition, in particular one according to the invention, with mucous membranes or open wounds could, for example, lead to irritation.

[0069] The composition according to the invention comprises curcumin in a mass fraction of 0.1% to 10%, preferably 0.5% to 5%, of the composition. The gel-like composition comprises Rose Bengal in a mass fraction of 0.01% to 1%, preferably 0.05% to 0.5%, of the composition. The combination of curcumin and Rose Bengal in the stated proportions leads to particularly effective disinfection of the tissue section.

[0070] The composition according to the invention comprises a gelling agent composition and water. The gelling agent composition forms the solid matrix of the gel-like composition. Water serves as a carrier substance for the remaining components of the gel-like composition, which is safe for wound treatment.

[0071] The gelling agent composition preferably contains a poloxamer, for example, Poloxamer 407, in a mass fraction of 0.2% to 20%, preferably 1% to 10%, of the composition. Poloxamers are block copolymers of ethylene oxide and propylene oxide. They are low-foam and foam-suppressing, nonionic surfactants. Poloxamer 407 has a relative mass fraction of ethylene oxide units of 70%, a relative molecular weight of the polypropylene glycol block of 4000, and a total average relative molecular weight of 9840 to 14600.

[0072] The gelling agent composition preferably contains 1,2-propylene glycol in a mass fraction of 0.13% to 13%, preferably 0.63% to 6.3%, of the composition. 1,2-Propylene glycol, also known as 1,2-propanediol, is a clear, colorless, virtually odorless, and highly hygroscopic liquid. 1,2-Propylene glycol is a harmless solvent and has antimicrobial properties, eliminating the need for additional preservatives.

[0073] The gelling agent composition preferably contains 2-propanol in a mass fraction of 0.13% to 13%, preferably 0.63% to 6.3%, of the composition. 2-Propanol (IUPAC name propan-2-ol), also known as isopropyl alcohol or isopropanol (abbreviated IPA), is the simplest non-cyclic, secondary alcohol and a monohydric alcohol. 2-Propanol is a low-toxicity solvent and has antimicrobial properties, eliminating the need for additional preservatives.

[0074] The gelling agent composition preferably contains medium-chain triglycerides in a mass fraction of 0.05% to 5%, preferably 0.25% to 2.5%, of the composition. Triglycerides, also known as glycerol triesters, are triple esters of the trihydric alcohol glycerol with three fatty acid molecules and, according to IUPAC recommendations, should be referred to as triacylglycerols. Medium-chain triglycerides have medium-length fatty acids (6 to 12 carbon atoms).

[0075] The composition according to the invention is preferably stable for at least 6 months from its preparation, particularly preferably for at least 12 months, especially when the composition is stored at refrigerator temperature.

[0076] The present disclosure also relates to a process for preparing a composition according to the invention.

[0077] The process involves mixing curcumin, rose bengal, poloxamer, 1,2-propylene glycol, 2-propanol, and water into a mixture. Mixing is carried out, for example, with a pestle or mortar in a mortar, particularly in a Fanta bowl.

[0078] The method comprises allowing the mixture to rest for a rest period of at least 30 minutes, preferably at least 45 minutes, particularly preferably at least 60 minutes. Allowing the mixture to rest allows air bubbles and / or gel clumps formed during mixing to dissolve.

[0079] During resting, the mixture is preferably covered to avoid contamination and may be stirred occasionally to assist in the dissolution of gel clumps and / or air bubbles.

[0080] The process involves mixing the medium-chain triglycerides into the mixture after allowing it to rest. This mixing creates a homogeneous gel.

[0081] Evaporation losses occurring during mixing, resting and / or blending can be compensated by stirring 2-propanol into the composition.

[0082] The method may comprise adjusting the pH of the composition to a slightly acidic pH, preferably from 6.0 to 6.7. A slightly acidic pH reduces the ability of bacteria commonly found in wound infections, for example Propionibacterium acnes.

[0083] The method may comprise filling the composition into a vessel, in particular into a cartridge according to the invention, wherein the vessel is tightly closed after filling in order to avoid contamination.

[0084] The composition is preferably stored at refrigerator temperature, for example at a temperature of 3°C to 9°C, to reduce the growth of microorganisms. Examples

[0085] The composition according to the invention consists, for example, of the following ingredients per 100 g of the composition: a. 10.0 g curcumin, b. 1.0 g rose bengal, c. 20.0 g poloxamer 407, d. 12.5 g propylene glycol, e. 12.5 g 2-propanol, f. 5.0 g medium-chain triglycerides and g. 39.0 g water.

[0086] The process for preparing a composition according to the invention, for example from the ingredients mentioned in the previous paragraph, comprises, for example, the following steps: a. In a Fanta dish tared with a pestle, curcumin, rose bengal, poloxamer are carefully mixed with propylene glycol, purified water, and 2-propanol. Air bubbles and gel clumps in the mixture are normal during this manufacturing step. b. The mixture is covered and left to stand for at least 60 minutes, stirring occasionally. After 60 minutes, the mixture is clear and viscous with few air bubbles. c. The medium-chain triglycerides are carefully mixed into the mixture. The mixture becomes white and viscous with few air bubbles. d. Evaporation losses are compensated with 2-propanol and stirred. e. The finished gel composition must appear white and homogeneous, smell of 2-propanol, and must not contain any air bubbles. f. The pH value should be between 6.0 and 6.7. Since bacteria, for example, Propionibacterium acnes,If the pH value is higher than 6.8, the pH value is adjusted below 6.8 if necessary. g. The gel-like composition is filled directly and tightly sealed.

[0087] A treatment of a wound carried out with the device according to the invention comprises, for example, the following steps, which are repeated, for example, twice a week for four weeks: a. Flushing the wound with the rinsing fluid to remove damaged tissue and / or foreign bodies, b. Applying the first composition, in particular according to the invention, for example as a thin film with a coverage density of 0.05 - 0.2 g / cm 2< , into the wound, c. Exposing the first composition to at least wavelengths of 405 nm, 430 nm, 470 nm and 490 nm for 10 minutes each, d. Wiping off the first composition after exposure, for example with a mild facial toner, e. Applying the second composition, in particular an aqueous solution of hypochlorous acid with a mole fraction of 400 ppm, where appropriate, reactive oxygen species can be removed with citric acid, f. Exposing the second composition to at least wavelengths of 405 nm, 430 nm, 470 nm and 490 nm for 10 minutes each.

[0088] A further treatment of a wound carried out with the device according to the invention comprises, for example, the following steps: a. Applying a composition, in particular an aqueous solution of hydrogen peroxide with a mass fraction of 1.5% or 3.0% or an aqueous solution of chlorhexidine with a mass fraction of 0.12%, into the wound; b. Exposing the composition to light with a wavelength of 405 nm for an exposure time of 3 minutes. Short description of the drawings

[0089] Further advantages, objects and features of the invention will be explained with reference to the following description and the accompanying drawings, in which exemplary objects according to the invention are shown. Figure 1 shows a schematic representation of a device according to the invention. Figure 2 shows a schematic representation of a cartridge according to the invention. Fig.1

[0090] Figure 1shows a schematic representation of a device 100 according to the invention for treating a tissue section W, in particular a wound, of a human or an animal.

[0091] The device 100 shown comprises a rinsing device 110 for rinsing the tissue section W with a rinsing fluid, wherein the rinsing device 110 comprises a rinsing opening 111 for delivering the rinsing fluid from the rinsing device 110 to the tissue section W.

[0092] The device 100 shown comprises a suction device 120 for suctioning the rinsing fluid from the tissue section W, wherein the suction device 120 comprises a suction opening 121 for receiving the rinsing fluid from the tissue section W into the suction device 120.

[0093] The device 100 shown comprises an application device 130 for applying a first composition, a second composition and a third composition for treating the tissue section W to the tissue section W, wherein the application device 130 comprises an application opening 131 for dispensing the compositions from the application device 130 to the tissue section W.

[0094] The application opening 131 is arranged, for example, near the rinsing opening 111. The application opening 131 can be identical to the rinsing opening 111.

[0095] The device 100 shown comprises an exposure device 140 for exposing the compositions applied to the tissue section W to light, wherein the exposure device 140 comprises an exit surface 141 for the exit of the light from the exposure device 140. The exposure device 140 comprises, for example, a diode laser for generating the light.

[0096] The device 100 shown comprises a carrying device 150 designed as a handpiece, wherein the rinsing opening 111, the suction opening 121, the application opening 131 and the exit surface 141 are integrated into the handpiece 150.

[0097] A distance A of the rinsing opening 111 from the suction opening 121 is, for example, from 1 mm to 5 mm. Fig.2

[0098] Figure 2 shows a schematic representation of a cartridge 200 according to the invention for use in a device 100 according to the invention.

[0099] The cartridge (200) shown comprises a first reservoir (210) containing the first composition, for example, a composition according to the invention, and a second reservoir (220), which is separated from the first reservoir (210) in a liquid-tight manner and contains the second composition, for example, an aqueous solution of hypochlorous acid. The cartridge (200) comprises a third reservoir 230, which is separated from the first reservoir 210 and the second reservoir 220 in a liquid-tight manner and contains the third composition, for example, an aqueous solution of hydrogen peroxide.

[0100] The cartridge shown has a first removal opening (211) for removing the first composition from the first reservoir (210), a second removal opening (221) for removing the second composition from the second reservoir (220) and a third removal opening 231 for removing the third composition from the third reservoir 230. List of reference symbols

[0101] 100 Device 150 Carrying device 110 Flushing device 200 cartridge 111 Flush opening 210 first reservoir 120 Suction device 211 first removal opening 121 Suction opening 220 second reservoir 130 Application device 221 second removal opening 131 Application opening 230 third reservoir 140 exposure device 231 third removal opening 141 Exit surface A Distance W Tissue section

Claims

1. A device (100) for treating a tissue portion (W), in particular a wound, of a human or of an animal, the device (100) comprising a. an application device (130) for applying a first composition, a second composition, and a third composition for treating the tissue section (W) onto the tissue section (W), wherein the application device (130) comprises at least one application opening (131) for dispensing the compositions from the application device (130) to the tissue section (W), and b. an exposure device (140) for exposing the compositions applied to the tissue section (W) with light, the exposure device (140) having an exit surface (141) for exiting the light from the exposure device (140), c. a carrying device (150), wherein the carrying device (150) carries the at least one application opening (131) and the exit surface (141), and d. a sound generator for exposing the first composition, the second composition, and / or the third composition during application to the tissue section (W) and / or a rinsing fluid during the rinsing of the tissue section (W) to sound, e. wherein the exposure device (140) is designed for emitting light having a wavelength in a range from 400 nm to 500 nm and in a range from 800 nm to 1400 nm, characterized in that f. the device (100) comprises a rinsing device (110) for rinsing the tissue section (W) with the rinsing fluid, wherein the rinsing device (110) comprises at least one rinsing opening (111) carried by the carrying device (150) for dispensing the rinsing fluid from the rinsing device (110) to the tissue section (W), g. wherein the rinsing device (110) comprises a pressure generator for supplying the rinsing fluid with an overpressure in a range from 1 bar to 80 bar above an atmospheric pressure, h. wherein the application device (130) contains at least one exchangeable cartridge (200) containing at least the second composition and the third composition, i. wherein the second composition is an aqueous solution of hypochlorous acid, and j. wherein the third composition is an aqueous solution of hydrogen peroxide.

2. The device (100) according to claim 1, characterized in that the device (100) comprises a suction device (120) for extracting the rinsing fluid from the tissue section (W), wherein the suction device (120) comprises at least one suction opening (121) carried by the carrying device (150) for receiving the rinsing fluid from the tissue section (W) into the suction device (120).

3. The device (100) according to claim 1, characterized in that the application device (130) comprises a flow control unit for controlling a flow of each of the three compositions onto the tissue section (W).

4. The device (100) according to claim 1, characterized in that the application device (130) comprises an atomizing unit for atomizing the first composition, the second composition, and / or the third composition upon application to the tissue section (W).

5. The device (100) according to claim 1, characterized in that the exposure device (140) is designed for emitting light having an intensity in a range of 50 mW / cm2 to 150 mW / cm2.

6. The device (100) according to claim 1, characterized in that the carrying device (150) is configured as a hand piece to be held by a practitioner with a hand for treating the tissue section (W).

7. The device (100) according to claims 1, characterized in that the carrying device (150) is configured as a tent for receiving the human or the animal.

8. The device (100) according to claims 1, characterized in that the carrying device (150) is configured as a breathing mask for respiration of the human or of the animal.

9. The device (100) according to claim 1, the cartridge (200) comprising a. a first reservoir (210) containing the first composition; b. a second reservoir (220), separated from the first reservoir (210) in a liquid-tight manner and containing the second composition; and c. a third reservoir (230), separated from the first reservoir (210) and from the second reservoir (220) in a liquid-tight manner and containing the third composition.

10. The device (100) according to claim 9, characterized in that the cartridge (200) comprises a first removal opening (211) for removing the first composition from the first reservoir (210), a second removal opening (221) for removing the second composition from the second reservoir (220), and a third removal opening (231) for removing the third composition from the third reservoir (230), wherein at least one of the removal openings (211, 221, 231) is closed by a valve.

11. The device (100) according to claim 1 comprising the first composition, wherein the first composition is gel-like and comprises the following components: a. curcumin with a mass fraction of from 0.1 % to 10 % of the first composition, b. rose bengal having a mass fraction of from 0.01 % to 1 % of the first composition, c. a gel-forming composition, and d. water.

12. The device (100) of claim 11, characterized in that the gel-forming composition comprises a. a poloxamer having a mass fraction of from 0.2 % to 20 % of the first composition, b. 1, 2-propylene glycol having a mass fraction of from 0.13 % to 13 % of the first composition, c. 2-propanol having a mass fraction of from 0.13 % to 13 % of the first composition, and / or d. medium chain-length triglycerides having a mass fraction of from 0.05 % to 5 % of the first composition.