HIGHLY WATER-SOLUBLE SALTS OF A SHORT-ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKER AND USES THEREBY
Patent Information
- Authority / Receiving Office
- DE · DE
- Patent Type
- Patents
- Current Assignee / Owner
- MILESTONE PHARMA INC
- Filing Date
- 2016-04-13
- Publication Date
- 2026-06-03
AI Technical Summary
Current therapeutic modalities for cardiac arrhythmias, such as PSVT, are invasive or inefficient, and existing calcium channel blockers do not provide immediate relief due to their pharmacokinetic profiles, which hinder rapid absorption and metabolism, leading to delayed symptom alleviation.
Development of highly water-soluble salts of calcium channel blockers, such as methanesulfonate salts, for nasal administration, allowing rapid delivery and metabolism of the active compound to terminate arrhythmia episodes.
The formulation enables rapid termination of cardiac arrhythmia episodes by achieving therapeutically effective plasma concentrations within minutes, thereby providing immediate relief without prolonged cardiac exposure or side effects.