BRUSH PRODRUGS AND USES THEREOF
DE602019085394T2Active Publication Date: 2026-06-03MASSACHUSETTS INST OF TECH
Patent Information
- Authority / Receiving Office
- DE · DE
- Patent Type
- Patents
- Current Assignee / Owner
- MASSACHUSETTS INST OF TECH
- Filing Date
- 2019-04-13
- Publication Date
- 2026-06-03
AI Technical Summary
Technical Problem
BET inhibitors, promising anti-cancer agents, face limitations due to hematological and gastrointestinal toxicity, which restrict their clinical development and patient compliance.
Method used
Development of Brush prodrugs of BET inhibitors, which improve biodistribution and minimize myelosuppression and GI toxicity by controlled release of free BET inhibitors in tumors, using macromonomers polymerized with metathesis catalysts.
Benefits of technology
The Brush prodrugs enhance the therapeutic index of BET inhibitors by sparing lymphocytes and neutrophils, reducing bone marrow suppression, and allowing tunable release of active agents, potentially improving treatment efficacy.
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