Immolative cell-penetrating complexes for nucleic acid delivery to the lungs
Patent Information
- Authority / Receiving Office
- DE · DE
- Patent Type
- Patents
- Current Assignee / Owner
- THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
- Filing Date
- 2020-01-31
- Publication Date
- 2026-06-10
AI Technical Summary
There is a need for improved materials and strategies to deliver therapeutic agents, diagnostic probes, and research tools across cellular membranes and biological barriers for clinical, diagnostic, and research applications, particularly for nucleic acid delivery in contexts such as vaccination, cancer immunotherapy, and gene editing.
Development of cationic amphipathic polymers and cell-penetrating complexes that non-covalently bind nucleic acids, featuring pH-sensitive immolation domains and lipophilic polymer domains, to facilitate efficient delivery across cellular membranes.
The complexes effectively deliver nucleic acids into cells, including reticulocytes and hematopoietic stem cells, and induce immune responses, offering therapeutic potential for various diseases and conditions.