IMPROVED METHOD FOR THE MANUFACTURE OF OSIMERTINIB
DE602023018328T2Active Publication Date: 2026-06-10ASTRAZENECA AB
Patent Information
- Authority / Receiving Office
- DE · DE
- Patent Type
- Patents
- Current Assignee / Owner
- ASTRAZENECA AB
- Filing Date
- 2023-04-06
- Publication Date
- 2026-06-10
AI Technical Summary
Technical Problem
The existing synthesis process for osimertinib requires a high volume of acetonitrile, leading to environmental impact and increased costs, with uncontrolled crystallization of intermediate compounds affecting purity and isolation.
Method used
A telescoped process using benzonitrile as a solvent for both Step A and Step B, eliminating the need to isolate intermediate compounds, reducing solvent volume, and avoiding hot filtration.
Benefits of technology
This approach reduces environmental impact and manufacturing costs while maintaining purity by keeping the intermediate compound in solution, facilitating easier isolation and reducing processing time.
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