Compound based on quinazoline-substituted glutarimide skeleton and use thereof

Abstract

The present disclosure provides a compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, or polymorphs thereof, and uses thereof. The present disclosure also provides pharmaceutical compositions comprising, as an active ingredient, the compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, or polymorphs thereof, and uses thereof. The series of compounds designed and synthesized in the present disclosure can effectively prevent and / or treat diseases or disorders associated with the cereblon protein.

Description

Technical Field

[0001] The present disclosure relates to a compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof, and uses thereof, especially their use in the prevention and / or treatment of diseases or disorders associated with cereblon protein (CRBN). Background

[0002] Although Thalidomide, lenalidomide and other phthalimide immunomodulatory drugs (IMiDs) have shown significant efficacy in the treatment of multiple myeloma and autoimmune diseases, it was not until 2010 that the E3 ubiquitin ligase cereblon (CRBN) was identified as a direct target of IMiDs. Subsequent research confirmed that these drugs function as molecular glue, inducing the interaction between transcription factors IKZF1 / 3 and CRBN protein, ultimately leading to their ubiquitination and degradation. Compared with traditional small molecule inhibitors, molecular glue protein degraders have natural mechanism advantages: the former works by occupying the functional domain of the target protein for a long time to inhibit its function, while the protein degraders directly degrade and eliminate the entire target protein, often having a much greater efficacy than traditional small molecule inhibitors. The protein degraders can target "non-drugable" targets, and have low requirements for binding force, catalytic capacity, and low concentration, which can overcome the clinical drug resistance problem of traditional small molecules. Moreover, molecular glue degraders usually have small molecular weights and desirable druggability, so the research and development of such drugs have received great attention. Based on the CRBN E3 ubiquitin ligase and molecular glue degradation mechanism, a series of compounds have been developed, such as pomalidomide, which has been launched, and CC-122 of Bristol-Myers Squibb (BMS), which is undergoing clinical trials, CC-220, CC-90009, CC-99282 and CC-92480, DKY709 from Novartis, and CFT7455 from C4 Therapeutics. The degradation substrates of these molecular glue have also expanded from the transcription factors IKZF1 / 3 initially discovered to include casein kinase 1α (CK1α), zinc finger protein 91 (ZFP91), and translation factor GSPT1. The degradation of these protein substrates will enable the molecular glues to exert immune regulatory, antiinflammatory, and anti-tumor pharmaceutical activities. Currently, the number of discovered candidate compounds for molecular glue is very limited, and there are theoretically a wide variety of pathogenic proteins that can be used as degradation substrates for the development of molecular glue. Therefore, it is necessary to design and develop more molecular glue through rationalization and diversification to degrade and eliminate more pathogenic proteins and apply them to the treatment of diseases associated with these pathogenic proteins.

[0003] The compounds listed above all contain the phthalimidyl backbone shared by thalidomide-type IMiDs. Another novel molecular glue, Avadomide (CC-122), developed by Bristol Myers Squibb (BMS), exhibits significant structural differences and remarkable pharmacological effects. Avadomide can bind to CRBN, leading to more pronounced degradation of IKZF1 and IKZF3, thereby downregulating cytokines such as TNF-α and exhibiting antitumor and immunomodulatory activities. Currently, Avadomide has entered Phase II clinical trials to test its therapeutic effects on various related tumors (NCT02406742, NCT02859324, NCT03834623). Based on the quinazolinyl-substituted glutarimide backbone of Avadomide, the present invention aims to develop more novel, highly effective, low-toxicity, stable, and cost-effective molecular glue degraders through rational design to meet the demands of clinical applications.Summary of Invention

[0004] In view of the above, the objectives of the present disclosure are to provide novel molecular glue protein degraders, their applications and usage methods.

[0005] To achieve the above objectives and other related goals, in one aspect, the present disclosure provides a compound of Formula (I): or a salt, stereoisomer (including enantiomer, diastereoisomer), isotopically enriched analog, solvate, prodrug, or polymorph thereof, wherein R c1 represents H or C 1-3 alkyl, and R c2 , R c3 , R c4 , R c5 and R c6 are the same or different and each independently represent H, D or C 1-3 alkyl; (R 1a ) n indicates that quinazoline ring of Formula (I) is optionally substituted with n R 1a , wherein R 1a represents halogen, and n represents an integer of 0, 1, 2, or 3; and R a represents the following formula:         R a1 -X 2 -L 1 -X 1 - , wherein X 1 represents optionally substituted cycloalkylene, optionally substituted heterocyclylene, optionally substituted arylene, or optionally substituted heteroarylene; L 1 represents optionally substituted linear or branched C 1-60 alkylene, or optionally substituted linear or branched C 2-60 alkylene with one or more groups R d1 and / or one or more groups R d2 and / or any combination of one or more groups R d1 and R d2 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R d1 , R d2 , or a combination of R d1 and R d2 ; wherein each R d1 is independently selected from the group consisting of O, S, N(R d3 ), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O) 2 , S(O) 2 O, OS(O) 2 , S(O) 2 NH or NHS(O) 2 , where R d3 represents H or C 1-3 alkyl, and in case that two or more groups R d1 are inserted into the backbone carbon chain of the linear or branched C 2-60 alkylene group, the two or more groups R d1 are not directly connected to each other; and wherein each R d2 is independently selected from the group consisting of optionally substituted cycloalkylene, optionally substituted heterocyclylene, optionally substituted arylene, optionally substituted heteroarylene, alkenylene, alkynylene, or any combination thereof; X 2 represents a bond; and R a1 represents NR d4 R d5 , C(O)NR d6 R d7 , NHC(O)Ras, NHC(O)NR d9 R d10 , C(O)OR d11 , OC(O)R d12 , OR d13 , SR d14 , C(O)R d15 , C(S)R d16 , S(O)R d17 , S(O) 2 R d18 , S(O) 2 NHR d19 , NHS(O) 2 R d20 , S(O) 2 OR d21 , OS(O) 2 Ra 22 , optionally substituted linear or branched C 1-10 alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl or optionally substituted heteroaryl, wherein R d4 , R d5 , R d6 , R d7 , R d9 , R d10 , R d11 , R d13 , R d14 , R d19 and R d21 each independently represent H, optionally substituted linear or branched C 1-10 alkyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heterocyclyl or optionally substituted heteroaryl, and Ras, R d12 , R d15 , R d16 , R d17 , R d18 , R d20 and R d22 represents optionally substituted linear or branched C 1-10 alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl or optionally substituted heteroaryl; or X 1 represents N(R e1 ), O, S, alkynylene, alkenylene, optionally substituted cycloalkylene, optionally substituted heterocyclylene, optionally substituted arylene, or optionally substituted heteroarylene, wherein R e1 represents H or C 1-3 alkyl, or X 1 represents a bond; L 1 represents optionally substituted linear or branched C 1-60 alkylene, or optionally substituted linear or branched C 2-60 alkylene with one or more groups R e2 and / or one or more groups R e3 and / or any combination of one or more groups R e2 and R e3 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R e2 , R e3 , or a combination of R e2 and R e3 ; wherein each R e2 is independently selected from the group consisting of O, S, N(R e4 ), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O) 2 , S(O) 2 O, OS(O) 2 , S(O) 2 NH, or NHS(O) 2 , wherein R e4 represents H or C 1-3 alkyl, and in case that two or more groups R e2 are inserted into the backbone carbon chain of the linear or branched C 2-60 alkylene group, the two or more groups R e2 are not directly connected to each other; and wherein each R e3 is independently selected from the group consisting of optionally substituted cycloalkylene, optionally substituted heterocyclylene, optionally substituted arylene, optionally substituted heteroarylene, alkenylene, alkynylene, or any combination thereof; X 2 represents C(O), S(O) or S(O) 2 , or X 2 represents a bond; R a1 represents the following formula: wherein R f1 represents:         -NCH 2 CH 2 N-; wherein symbol * indicates the point of attachment to X 2 , R g1 represents H or C 1-3 alkyl, ring A represents cycloalkylene or heterocyclylene, and (R g2 ) n1 indicates that ring A is optionally substituted with n1 R g2 groups, wherein n1 represents an integer of 0 to 8, and each R g2 , the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 alkoxy, halogenated C 1-6 alkyl, NH 2 -C 1-6 alkylene or any combination thereof; wherein symbol ** indicates the point of attachment to X 2 , R g3 represents H or C 1-3 alkyl, ring B represents cycloalkylene or heterocyclylene, (R g4 ) n2 indicates that ring B is optionally substituted with n2 R g4 , wherein n2 represents an integer of 0 to 8, and each R g4 , the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 alkoxy, halogenated C 1-6 alkyl, NH 2 -C 1-6 alkylene or any combination thereof; or wherein ring C represents cycloalkylene or heterocyclylene, (R g5 ) n3 indicates that ring C is optionally substituted with n3 R g5 groups, wherein n3 represents an integer of 0 to 8, and each R g5 , the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 alkoxy, halogenated C 1-6 alkyl, NH 2 -C 1-6 alkylene or any combination thereof; R f2 represents H, halogen, C 1-3 alkyl or halogenated C 1-3 alkyl; R f3 represents H, halogen, C 1-3 alkyl, halogenated C 1-3 alkyl, or wherein ring D represents cycloalkylene, heterocyclylene, arylene or heteroarylene, (R g6 ) n4 indicates that ring D is optionally substituted with n4 R g6 groups, wherein n4 represents an integer of 0 to 8, and each R g6 , the same or different from each other, is independently selected from the group consisting of optionally deuterated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 alkoxy, halogenated C 1-6 alkyl, NH 2 -C 1-6 alkylene or any combination thereof; R f4 represents wherein symbol *** indicates the point of attachment to R f5 , ring E represents cycloalkylene, heterocyclylene, arylene or heteroarylene, (R g7 ) n5 indicates that ring E is optionally substituted with n5 R g7 , wherein n5 represents an integer of 0 to 8, and each R g7 , the same or different from each other, is independently selected from the group consisting of optionally deuterated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 alkoxy, halogenated C 1-6 alkyl, NH 2 -C 1-6 alkylene or any combination thereof; and R f5 represents H, halogen, C 1-3 alkyl, halogenated C 1-3 alkyl, or wherein ring F represents cycloalkyl, heterocyclyl, aryl or heteroaryl, (R g8 ) n6 indicates that ring F is optionally substituted with n6 R g8 , wherein n6 represents an integer of 0 to 8, and each R g8 , the same or different from each other, is independently selected from the group consisting of optionally deuterated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 alkoxy, halogenated C 1-6 alkyl, NH 2 -C 1-6 alkylene or any combination thereof; or X 1 represents N(R 1 ), O, S, alkynylene, or alkenylene, wherein R 1 represents H or C 1-3 alkyl, or X 1 represents a bond; L 1 represents optionally substituted linear or branched C 1-60 alkylene; X 2 represents N(R 2 ), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O) 2 , S(O) 2 NH, NHS(O) 2 , S(O) 2 O, OS(O) 2 , optionally substituted 4- to 8-membered heterocyclylene containing 1 to 2 nitrogen atoms, triazolylene, triazolylene-NH-, -NH-triazolylene, or optionally substituted phenylene, wherein R 2 represents H or C 1-3 alkyl, or X 2 represents a bond; and R a1 represents hydroxy, optionally substituted adamantanyl, optionally substituted noradamantanyl, optionally substituted cubanyl, optionally substituted spirocycloalkyl, optionally substituted bicyclo[2.2.2]octan-1-yl, optionally substituted bicyclo[2.2.2]octan-2-yl, optionally substituted bornyl, optionally substituted bicyclo[2.2.1]heptanyl, optionally substituted bicyclo[2.2.1]heptenyl, optionally substituted p-menthanyl or optionally substituted m-menthanyl, wherein when R a1 represents hydroxy, X 2 represents a bond; or X 1 represents N(R 3 ), O or S, wherein R 3 represents H or C 1-3 alkyl; L 1 represents optionally substituted linear or branched C 4-60 alkylene; X 2 represents N(R 4 ), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O) 2 , S(O) 2 NH, NHS(O) 2 , S(O) 2 O, or OS(O) 2 , wherein R 4 represents H or C 1-3 alkyl, or X 2 represents a bond; and R a1 represents optionally substituted heterocyclyl; or X 1 represents alkynylene or alkenylene, or X 1 represents a bond; L 1 represents optionally substituted linear or branched C 1-60 alkylene; and X 2 represents N(R 5 ), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O) 2 , S(O) 2 NH, NHS(O) 2 , S(O) 2 O, or OS(O) 2 , wherein R 5 represents H or C 1-3 alkyl, or X 2 represents a bond; and R a1 represents optionally substituted heterocyclyl; or X 1 represents N(R 6 ), O, S, alkynylene, or alkenylene, wherein R 6 represents H or C 1-3 alkyl, or X 1 represents a bond; L 1 represents optionally substituted linear or branched C 2-60 alkylene with one or more groups R 7 and / or one or more groups R 8 and / or any combination of one or more groups R 7 and R 8 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R 7 , R 8 , or a combination of R 7 and R 8 ; wherein each R 7 is independently selected from the group consisting of O, S, N(R 9 ), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O) 2 , S(O) 2 O, OS(O) 2 , S(O) 2 NH or NHS(O) 2 , wherein R 9 represents H or C 1-3 alkyl, and in case that two or more groups R 7 are inserted into the backbone carbon chain of the linear or branched C 2-60 alkylene group, the two or more groups R 7 are not directly connected to each other; and wherein each R 8 is independently selected from the group consisting of cycloalkylene, heterocyclylene, triazolylene, alkenylene, alkynylene or any combination thereof, wherein the cycloalkylene, heterocyclylene and triazolylene are each independently optionally substituted with a substituent selected from the group consisting of D, optionally deuterated C 1-4 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, cyano or any combination thereof; X 2 represents N(R 10 ), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O) 2 , S(O) 2 NH, NHS(O) 2 , S(O) 2 O, OS(O) 2 , optionally substituted 4- to 8-membered heterocyclylene containing 1 to 2 nitrogen atoms, triazolylene, triazolylene-NH-, -NH-triazolylene, or optionally substituted phenylene, wherein R 10 represents H or C 1-3 alkyl, or X 2 represents a bond; and R a1 represents hydroxy, optionally substituted heterocyclyl or optionally substituted cycloalkyl, wherein when R a1 represents hydroxy, X 2 represents a bond; or R a represents the following formula:         R a2 -X 3 -, wherein X 3 represents N(R 11 ), C(O)O, OC(O), C(O)NH, NHC(O), O, S, optionally substituted cycloalkylene, optionally substituted arylene, optionally substituted heteroarylene or optionally substituted heterocyclylene, wherein R 11 represents H or C 1-3 alkyl, and R a2 represents optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heteroaryl or optionally substituted aryl; and R b represents C 1-60 alkyl optionally substituted with D or halogen, or R b represents the following formula:         R b1 -X 4 -L 2 -, wherein L 2 represents optionally substituted linear or branched C 2-60 alkylene, or optionally substituted linear or branched C 2-60 alkylene with one or more groups R 12 and / or one or more groups R 13 and / or any combination of one or more groups R 12 and R 13 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R 12 , R 13 , or a combination of R 12 and R 13 ; wherein each R 12 is independently selected from the group consisting of O, S, N(R 14 ), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O) 2 , S(O) 2 O, OS(O) 2 , S(O) 2 NH or NHS(O) 2 , wherein R 14 independently represents H or C 1-3 alkyl, and in case that two or more groups R 12 are inserted into the backbone carbon chain of the linear or branched C 2-60 alkylene group, the two or more groups R 12 are not directly connected to each other; and wherein each R 13 is independently selected from the group consisting of cycloalkylene, heterocyclylene, arylene, heteroarylene, alkenylene, alkynylene or any combination thereof, wherein the cycloalkylene, heterocyclylene, arylene and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of D, optionally deuterated C 1-4 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, cyano or any combination thereof; X 4 represents N(R 15 ), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O) 2 , S(O) 2 NH, NHS(O) 2 , S(O) 2 O, OS(O) 2 , optionally substituted cycloalkylene, optionally substituted arylene, optionally substituted heterocyclylene, optionally substituted heteroarylene, triazolylene-NH-, or -NH-triazolylene, wherein R 15 represents H or C 1-3 alkyl, or X 4 represents a bond; and R b1 represents optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heterocyclyl or optionally substituted heteroaryl; or R a represents halogen or cyano, and R b represents the following formula:         R b2 -X 5 -L 3 -, wherein L 3 represents optionally substituted linear or branched C 2-60 alkylene, or optionally substituted linear or branched C 2-60 alkylene with one or more groups R 16 and / or one or more groups R 17 and / or any combination of one or more groups R 16 and R 17 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R 16 , R 17 , or a combination of R 16 and R 17 ; wherein each R 16 is independently selected from the group consisting of O, S, N(R 18 ), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O) 2 , S(O) 2 O, OS(O) 2 , S(O) 2 NH or NHS(O) 2 , wherein R 18 represents H or C 1-3 alkyl, and in case that two or more groups R 16 are inserted into the backbone carbon chain of the linear or branched C 2-60 alkylene group, the two or more groups R 16 are not directly connected to each other; and wherein each R 17 is independently selected from the group consisting of cycloalkylene, heterocyclylene, arylene, heteroarylene, alkenylene, alkynylene or any combination thereof, wherein the cycloalkylene, heterocyclylene, arylene and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of D, optionally deuterated C 1-4 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, cyano or any combination thereof; X 5 represents N(R 19 ), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O) 2 , S(O) 2 NH, NHS(O) 2 , S(O) 2 O, or OS(O) 2 , wherein R 19 represents H or C 1-3 alkyl, or X 5 represents a bond; and R 12 represents optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heterocyclyl or optionally substituted heteroaryl, or represents the following formula: wherein R f1 , R f2 , R f3 , R f4 and R f5 are defined as above.

[0006] In another aspect, the present disclosure provides a pharmaceutical composition comprising the compound of Formula (I) or pharmaceutically acceptable salts, stereoisomers (including enantiomers, diastereoisomer), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, and at least one pharmaceutically acceptable carrier.

[0007] In a further aspect, the present disclosure further provides a medicine kit or reagent kit comprising: the compound of Formula (I) or a pharmaceutically acceptable salt, or the pharmaceutical composition comprising the same.

[0008] In a further aspect, the present disclosure provides the compound of Formula (I) or pharmaceutically acceptable salts, enantiomers, diastereoisomer, solvates, prodrugs, or polymorphs thereof, for use as a medicament.

[0009] In a further aspect, the present disclosure provides the compound of Formula (I) or pharmaceutically acceptable salts, stereoisomers (including enantiomers, diastereoisomer), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, or the pharmaceutical composition for use in the prevention or treatment of diseases or disorders associated with cereblon protein.

[0010] In a further aspect, the present disclosure provides use of the compound of Formula (I) or pharmaceutically acceptable salts, stereoisomers (including enantiomers, diastereoisomer), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, or the pharmaceutical composition of the present disclosure for the manufacture of a medicament for the prevention or treatment of diseases or disorders associated with cereblon protein.

[0011] In a further aspect, the present disclosure provides a method for treating or preventing diseases or disorders associated with cereblon protein in a subject, comprising administering to the subject a therapeutically effective amount of the compound of Formula (I) or pharmaceutically acceptable salts, stereoisomers (including enantiomers, diastereoisomer), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, or the pharmaceutical composition.Detailed Description of the Invention

[0012] The following detailed description is provided as exemplary specific embodiments to assist those skilled in the art in understanding and practicing the present disclosure. It should be appreciated, however, that such description is not intended to limit the scope of the present disclosure, and that various modifications and changes may be made to the specific embodiments described in the present disclosure without departing from the spirit and scope of the present disclosure. Such changes and modifications are to be understood as being included within the scope of the present invention as defined by the appended claims.I. Compounds Compounds of Formula (I)

[0013] The present disclosure provides a compound of Formula (I): or salts (including pharmaceutically acceptable salts), stereoisomers (including enantiomers, diastereoisomer), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, wherein R c1 , R c2 , R c3 , R c4 , R c5 , R c6 , R b , (R 1a ) n , R a , R 1a and n are as defined in the compound of Formula (I) and its various embodiments herein.

[0014] In some embodiments of the present disclosure, R c1 represents H or C 1-3 alkyl (e.g., methyl, ethyl, or propyl).

[0015] In some embodiments of the present disclosure, R c1 represents H.

[0016] In some embodiments of the present disclosure, R c2 , R c3 , R c4 , R c5 and R c6 are the same or different and each independently represent H, D or C 1-3 alkyl (e.g., methyl, ethyl, or propyl). In some sub-embodiments of the present disclosure, R c2 , R c3 , R c4 , R c5 and R c6 are the same or different and each independently represent H.

[0017] In some embodiments of the present disclosure, (R 1a ) n indicates that quinazoline ring of Formula (I) is optionally substituted with n R 1a , wherein R 1a represents halogen (e.g., fluorine, chlorine, bromine, or iodine), and n represents an integer of 0, 1, 2 or 3. In some sub-embodiments of the present disclosure, n represents an integer of 0.

[0018] In some embodiments of the present disclosure, the compound of Formula (I) is also of Formula (I-1): wherein R c1 , R c2 , R c3 , R c4 , R c5 , R c6 , R b , (R 1a ) n , R a , R 1a and n are as defined in the compound of Formula (I) above and its various embodiments herein; wherein R a represents the following formula:         R a1 -X 2 -L 1 -X 1 - , wherein X 1 represents optionally substituted cycloalkylene (e.g., optionally substituted C 3-20 cycloalkylene, or optionally substituted C 3-15 cycloalkylene), optionally substituted heterocyclylene (e.g., optionally substituted 4- to 20-membered heterocyclylene, or optionally substituted 4- to 15-membered heterocyclylene), optionally substituted arylene (e.g., optionally substituted C 6-10 arylene), or optionally substituted heteroarylene (e.g., optionally substituted 5-to 20-membered heteroarylene, or optionally substituted 5- to 15-membered heteroarylene); L 1 represents: optionally substituted linear or branched C 1-60 alkylene (e.g., C 1 -C 40 alkylene, C 1 -C 30 alkylene, C 1 -C 29 alkylene, C 1 -C 28 alkylene, C 1 -C 27 alkylene, C 1 -C 26 alkylene, C 1 -C 25 alkylene, C 1 -C 24 alkylene, C 1 -C 23 alkylene, C 1 -C 22 alkylene, C 1 -C 21 alkylene, C 1 -C 20 alkylene, C 1 -C 19 alkylene, C 1 -C 18 alkylene, C 1 -C 17 alkylene, C 1 -C 16 alkylene, C 1 -C 15 alkylene, C 1 -C 14 alkylene, C 1 -C 13 alkylene, C 1 -C 12 alkylene, C 1 -C 11 alkylene, C 1 -C 10 alkylene, C 1 -C 9 alkylene, C 1 -C 8 alkylene, C 1 -C 7 alkylene, C 1 -C 6 alkylene, C 1 -C 5 alkylene, C 1 -C 4 alkylene, C 1 -C 3 alkylene, or C 1 -C 2 alkylene), or optionally substituted linear or branched C 2-60 alkylene (e.g., C 2 -C 40 alkylene, C 2 -C 30 alkylene, C 2 -C 29 alkylene, C 2 -C 28 alkylene, C 2 -C 27 alkylene, C 2 -C 26 alkylene, C 2 -C 25 alkylene, C 2 -C 24 alkylene, C 2 -C 23 alkylene, C 2 -C 22 alkylene, C 2 -C 21 alkylene, C 2 -C 20 alkylene, C 2 -C 19 alkylene, C 2 -C 18 alkylene, C 2 -C 17 alkylene, C 2 -C 16 alkylene, C 2 -C 15 alkylene, C 2 -C 14 alkylene, C 2 -C 13 alkylene, C 2 -C 12 alkylene, C 2 -C 11 alkylene, C 2 -C 10 alkylene, C 2 -C 9 alkylene, C 2 -C 8 alkylene, C 2 -C 7 alkylene, C 2 -C 6 alkylene, C 2 -C 5 alkylene, C 2 -C 4 alkylene, C 2 -C 3 alkylene, or ethylene) with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R d1 and / or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R d2 and / or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R d1 and R d2 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs (e.g., 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1 pair) of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R d1 , R d2 , or a combination of R d1 and R d2 ; wherein each R d1 is independently selected from the group consisting of O, S, N(R d3 ), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O) 2 , S(O) 2 O, OS(O) 2 , S(O) 2 NH or NHS(O) 2 , where R d3 represents H or C 1-3 alkyl (e.g., methyl, ethyl, or propyl), and in case that two or more groups R d1 are inserted into the backbone carbon chain of the linear or branched C 2-60 alkylene group, the two or more groups R d1 are not directly connected to each other; and wherein each R d2 is independently selected from the group consisting of optionally substituted cycloalkylene (e.g., optionally substituted C 3-20 cycloalkylene, or optionally substituted C 3-15 cycloalkylene), optionally substituted heterocyclylene (e.g., optionally substituted 4- to 20-membered heterocyclylene, or optionally substituted 5- to 15-membered heterocyclylene), optionally substituted arylene (e.g., optionally substituted C 6-10 arylene), optionally substituted heteroarylene (e.g., optionally substituted 5- to 20-membered heteroarylene, or optionally substituted 5- to 15-membered heteroarylene), alkenylene (e.g., C 2-6 alkenylene), alkynylene (e.g., C 2-6 alkynylene) or any combination thereof; X 2 represents a bond; and R a1 represents NR d4 R d5 , C(O)NR d6 R d7 , NHC(O)R d8 , NHC(O)NR d9 R d10 , C(O)OR d11 , OC(O)R d12 , OR d13 , SR d14 , C(O)R d15 , C(S)R d16 , S(O)R d17 , S(O) 2 R d18 , S(O) 2 NHR d19 , NHS(O) 2 R d20 , S(O) 2 OR d21 , OS(O) 2 R d22 , optionally substituted linear or branched C 1-10 alkyl, optionally substituted cycloalkyl (e.g., optionally substituted C 3-20 cycloalkyl, or optionally substituted C 3-15 cycloalkyl), optionally substituted heterocyclyl (e.g., optionally substituted 4- to 20-membered heterocyclyl, or optionally substituted 5- to 15-membered heterocyclyl), optionally substituted aryl (e.g., optionally substituted C 6-20 aryl, or optionally substituted C 6-10 aryl) or optionally substituted heteroaryl (e.g., optionally substituted 5- to 20-membered heteroaryl, or optionally substituted 5-to 15-membered heteroaryl), wherein R d4 , R d5 , R d6 , R d7 , R d9 , R d10 , R d11 , R d13 , R d14 , R d19 and R d21 each independently represent H, optionally substituted linear or branched C 1-10 alkyl, optionally substituted cycloalkyl (e.g., optionally substituted C 3-20 cycloalkyl, or optionally substituted C 3-15 cycloalkyl), optionally substituted aryl (e.g., optionally substituted C 6-20 aryl, or optionally substituted C 6-10 aryl), optionally substituted heterocyclyl (e.g., optionally substituted 4- to 20-membered heterocyclyl, or optionally substituted 5- to 15-membered heterocyclyl) or optionally substituted heteroaryl (e.g., optionally substituted 5- to 20-membered heteroaryl, or optionally substituted 5- to 15-membered heteroaryl), and R d8 , R d12 , R d15 , R d16 , R d17 , R d18 , R d20 and R d22 represents optionally substituted linear or branched C 1-10 alkyl, optionally substituted cycloalkyl (e.g., optionally substituted C 3-20 cycloalkyl, or optionally substituted C 3-15 cycloalkyl), optionally substituted heterocyclyl (e.g., optionally substituted 4- to 20-membered heterocyclyl, or optionally substituted 5- to 15-membered heterocyclyl), optionally substituted aryl (e.g., optionally substituted C 6-20 aryl, or optionally substituted C 6-10 aryl) or optionally substituted heteroaryl (e.g., optionally substituted 5- to 20-membered heteroaryl, or optionally substituted 5-to 15-membered heteroaryl); and R 1 represents C 1-60 alkyl (e.g., C 1 -C 30 alkyl, C 1 -C 29 alkyl, C 1 -C 28 alkyl, C 1 -C 27 alkyl, C 1 -C 26 alkyl, C 1 -C 25 alkyl, C 1 -C 24 alkyl, C 1 -C 23 alkyl, C 1 -C 22 alkyl, C 1 -C 21 alkyl, C 1 -C 20 alkyl, C 1 -C 19 alkyl, C 1 -C 18 alkyl, C 1 -C 17 alkyl, C 1 -C 16 alkyl, C 1 -C 15 alkyl, C 1 -C 14 alkyl, C 1 -C 13 alkyl, C 1 -C 12 alkyl, C 1 -C 11 alkyl, C 1 -C 10 alkyl, C 1 -C 9 alkyl, C 1 -C 8 alkyl, C 1 -C 7 alkyl, C 1 -C 6 alkyl, C 1 -C 5 alkyl, C 1 -C 4 alkyl, C 1 -C 3 alkyl, or C 1 -C 2 alkyl) optionally substituted with D or halogen, or R b represents the following formula:         R b1 -X 4 -L 2 -, wherein L 2 represents: optionally substituted linear or branched C 2-60 alkylene (e.g., C 2 -C 40 alkylene, C 2 -C 30 alkylene, C 2 -C 29 alkylene, C 2 -C 28 alkylene, C 2 -C 27 alkylene, C 2 -C 26 alkylene, C 2 -C 25 alkylene, C 2 -C 24 alkylene, C 2 -C 23 alkylene, C 2 -C 22 alkylene, C 2 -C 21 alkylene, C 2 -C 20 alkylene, C 2 -C 19 alkylene, C 2 -C 18 alkylene, C 2 -C 17 alkylene, C 2 -C 16 alkylene, C 2 -C 15 alkylene, C 2 -C 14 alkylene, C 2 -C 13 alkylene, C 2 -C 12 alkylene, C 2 -C 11 alkylene, C 2 -C 10 alkylene, C 2 -C 9 alkylene, C 2 -C 8 alkylene, C 2 -C 7 alkylene, C 2 -C 6 alkylene, C 2 -C 5 alkylene, C 2 -C 4 alkylene, C 2 -C 3 alkylene, or ethylene), or optionally substituted linear or branched C 2-60 alkylene (e.g., C 2 -C 40 alkylene, C 2 -C 30 alkylene, C 2 -C 29 alkylene, C 2 -C 28 alkylene, C 2 -C 27 alkylene, C 2 -C 26 alkylene, C 2 -C 25 alkylene, C 2 -C 24 alkylene, C 2 -C 23 alkylene, C 2 -C 22 alkylene, C 2 -C 21 alkylene, C 2 -C 20 alkylene, C 2 -C 19 alkylene, C 2 -C 18 alkylene, C 2 -C 17 alkylene, C 2 -C 16 alkylene, C 2 -C 15 alkylene, C 2 -C 14 alkylene, C 2 -C 13 alkylene, C 2 -C 12 alkylene, C 2 -C 11 alkylene, C 2 -C 10 alkylene, C 2 -C 9 alkylene, C 2 -C 8 alkylene, C 2 -C 7 alkylene, C 2 -C 6 alkylene, C 2 -C 5 alkylene, C 2 -C 4 alkylene, C 2 -C 3 alkylene, or ethylene) with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R 12 and / or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R 13 and / or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R 12 and R 13 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs (e.g., 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1 pair) of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R 12 , R 13 , or a combination of R 12 and R 13 ; wherein each R 12 is independently selected from the group consisting of O, S, N(R 14 ), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O) 2 , S(O) 2 O, OS(O) 2 , S(O) 2 NH or NHS(O) 2 , wherein R 14 independently represents H or C 1-3 alkyl, and in case that two or more groups R 12 are inserted into the backbone carbon chain of the linear or branched C 2-60 alkylene group, the two or more groups R 12 are not directly connected to each other; and wherein each R 13 is independently selected from the group consisting of cycloalkylene (e.g., C 3-20 cycloalkylene, or C 3-15 cycloalkylene), heterocyclylene (e.g., 4- to 20-membered heterocyclylene, or 4- to 15-membered heterocyclylene), arylene (e.g., C 6-10 arylene), heteroarylene (e.g., 5- to 20-membered heteroarylene, or 5- to 15-membered heteroarylene), alkenylene (e.g., C 2-6 alkenylene), alkynylene (e.g., C 2-6 alkynylene) or any combination thereof, wherein the cycloalkylene, the heterocyclylene, arylene and the heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of D, optionally deuterated C 1-4 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, cyano or any combination thereof; X 4 represents N(R 15 ), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(=S), S, S(O), S(O) 2 , S(O) 2 NH, NHS(O) 2 , S(O) 2 O, OS(O) 2 , optionally substituted cycloalkylene (e.g., optionally substituted C 3-20 cycloalkylene, or optionally substituted C 3-15 cycloalkylene), optionally substituted arylene (e.g., optionally substituted C 6-20 arylene, or optionally substituted C 6-10 arylene), optionally substituted heterocyclylene (e.g., optionally substituted 4- to 20-membered heterocyclylene, or optionally substituted 4- to 15-membered heterocyclylene), optionally substituted heteroarylene (e.g., optionally substituted 5- to 20-membered heteroarylene, or optionally substituted 5- to 15-membered heteroarylene), triazolylene-NH-, or -NH-triazolylene, wherein R 15 represents H or C 1-3 alkyl, or X 4 represents a bond; and R b1 represents optionally substituted cycloalkyl (e.g., optionally substituted C 3-20 cycloalkyl, or optionally substituted C 3-15 cycloalkyl), optionally substituted aryl (e.g., optionally substituted C 6-20 aryl, or optionally substituted C 6-10 aryl), optionally substituted heterocyclyl (e.g., optionally substituted 4- to 20-membered heterocyclyl, or optionally substituted 4- to 15-membered heterocyclyl) or optionally substituted heteroaryl (e.g., optionally substituted 5- to 20-membered heteroaryl, or optionally substituted 5- to 15-membered heteroaryl).

[0019] In embodiments of the present disclosure, the number of substituents is not theoretically limited in any way or automatically limited by the size of the building units.

[0020] In some embodiments of the compound of Formula (I-1), R a represents the following formula:         R a1 -X 2 -L 1 -X 1 -, wherein X 1 represents optionally substituted C 3-20 cycloalkylene (e.g., optionally substituted C 3-15 cycloalkylene), optionally substituted 4- to 20-membered nitrogen-containing heterocyclylene (e.g., optionally substituted 4- to 15-membered nitrogen-containing heterocyclylene), optionally substituted C 6-10 arylene, or optionally substituted 5- to 20-membered heteroarylene (e.g., optionally substituted 5- to 15-membered heteroarylene); L 1 represents: optionally substituted linear or branched C 1-60 alkylene (e.g., C 1 -C 40 alkylene, C 1 -C 30 alkylene, C 1 -C 29 alkylene, C 1 -C 28 alkylene, C 1 -C 27 alkylene, C 1 -C 26 alkylene, C 1 -C 25 alkylene, C 1 -C 24 alkylene, C 1 -C 23 alkylene, C 1 -C 22 alkylene, C 1 -C 21 alkylene, C 1 -C 20 alkylene, C 1 -C 19 alkylene, C 1 -C 18 alkylene, C 1 -C 17 alkylene, C 1 -C 16 alkylene, C 1 -C 15 alkylene, C 1 -C 14 alkylene, C 1 -C 13 alkylene, C 1 -C 12 alkylene, C 1 -C 11 alkylene, C 1 -C 10 alkylene, C 1 -C 9 alkylene, C 1 -C 8 alkylene, C 1 -C 7 alkylene, C 1 -C 6 alkylene, C 1 -C 5 alkylene, C 1 -C 4 alkylene, C 1 -C 3 alkylene, or C 1 -C 2 alkylene), or optionally substituted linear or branched C 2-60 alkylene (e.g., C 2 -C 40 alkylene, C 2 -C 30 alkylene, C 2 -C 29 alkylene, C 2 -C 28 alkylene, C 2 -C 27 alkylene, C 2 -C 26 alkylene, C 2 -C 25 alkylene, C 2 -C 24 alkylene, C 2 -C 23 alkylene, C 2 -C 22 alkylene, C 2 -C 21 alkylene, C 2 -C 20 alkylene, C 2 -C 19 alkylene, C 2 -C 18 alkylene, C 2 -C 17 alkylene, C 2 -C 16 alkylene, C 2 -C 15 alkylene, C 2 -C 14 alkylene, C 2 -C 13 alkylene, C 2 -C 12 alkylene, C 2 -C 11 alkylene, C 2 -C 10 alkylene, C 2 -C 9 alkylene, C 2 -C 8 alkylene, C 2 -C 7 alkylene, C 2 -C 6 alkylene, C 2 -C 5 alkylene, C 2 -C 4 alkylene, C 2 -C 3 alkylene, or ethylene) with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R d1 and / or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R d2 and / or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R d1 and R d2 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs (e.g., 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1 pair) of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R d1 , R d2 , or a combination of R d1 and R d2 ; wherein each R d1 is independently selected from the group consisting of O, S, N(R d3 ), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O) 2 , S(O) 2 O, OS(O) 2 , S(O) 2 NH or NHS(O) 2 , where R d3 represents H or C 1-3 alkyl, and in case that two or more groups R d1 are inserted into the backbone carbon chain of the linear or branched C 2-60 alkylene group, the two or more groups R d1 are not directly connected to each other; and wherein each R d2 is independently selected from the group consisting of optionally substituted C 3-15 cycloalkylene, optionally substituted 4- to 15-membered heterocyclylene, optionally substituted C 6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C 2-6 alkenylene, C 2-6 alkynylene or any combination thereof, wherein the C 3-15 cycloalkylene, the C 6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 alkoxy, optionally deuterated C 1-6 alkyl-NH-, halogenated C 1-6 alkyl, NH 2 -C 1-6 alkylene, optionally deuterated C 1-6 alkyl-NHC(O)-, optionally deuterated C 1-6 alkyl-C(O)NH- or any combination thereof, wherein the linear or branched C 1-60 alkylene and the linear or branched C 2-60 alkylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C 1-6 alkoxy, halogenated C 1-6 alkyl, or any combination thereof; X 2 represents a bond; and R a1 represents NR d4 R d5 , C(O)NR d6 R d7 , NHC(O)Ras, NHC(O)NR d9 R d10 , C(O)OR d11 , OC(O)R d12 , OR d13 , SR d14 , C(O)R d15 , C(S)R d16 , S(O)R d17 , S(O) 2 R d18 , S(O) 2 NHR d19 , NHS(O) 2 R d20 , S(O) 2 OR d21 , OS(O) 2 R d22 , optionally substituted linear or branched C 1-10 alkyl, optionally substituted C 3-20 cycloalkyl (e.g., optionally substituted C 3-15 cycloalkyl), optionally substituted 4- to 20-membered heterocyclyl (e.g., optionally substituted 5- to 15-membered heterocyclyl), optionally substituted C 6-20 aryl (e.g., optionally substituted C 6-10 aryl) or optionally substituted 5- to 20-membered heteroaryl (e.g., optionally substituted 5- to 15-membered heteroaryl), wherein R d4 , R d5 , R d6 , R d7 , R d9 , R d10 , R d11 , R d13 , R d14 , R d19 and R d21 are the same or different and each independently represent H, optionally substituted linear or branched C 1-10 alkyl, optionally substituted C 3-20 cycloalkyl (e.g., optionally substituted C 3-15 cycloalkyl), optionally substituted C 6-20 aryl (e.g., optionally substituted C 6-10 aryl), optionally substituted 4- to 20-membered heterocyclyl (e.g., optionally substituted 5- to 15-membered heterocyclyl) or optionally substituted 5- to 20-membered heteroaryl (e.g., optionally substituted 5- to 15-membered heteroaryl), and R d8 , R d12 , R d15 , R d16 , R d17 , R d18 , R d20 and R d22 each independently represent optionally substituted linear or branched C 1-10 alkyl, optionally substituted C 3-20 cycloalkyl (e.g., optionally substituted C 3-15 cycloalkyl), optionally substituted 4- to 20-membered heterocyclyl (e.g., optionally substituted 5- to 15-membered heterocyclyl), optionally substituted C 6-20 aryl (e.g., optionally substituted C 6-10 aryl) or optionally substituted 5- to 20-membered heteroaryl (e.g., optionally substituted 5- to 15-membered heteroaryl).

[0021] In some embodiments of the compound of Formula (I-1), X 1 represents: optionally substituted C 3-20 cycloalkylene (e.g., optionally substituted C 3-15 cycloalkylene), optionally substituted 4- to 20-membered nitrogen-containing monocyclic heterocyclylene (e.g., optionally substituted 4- to 15-membered nitrogen-containing monocyclic heterocyclylene), optionally substituted 5- to 20-membered nitrogen-containing bridged heterocyclylene (e.g., optionally substituted 5- to 15-membered nitrogen-containing bridged heterocyclylene), optionally substituted 5- to 20-membered nitrogen-containing spiro-heterocyclylene (e.g., optionally substituted 5- to 15-membered nitrogen-containing spiro-heterocyclylene), optionally substituted 5- to 20-membered nitrogen-containing fused heterocyclylene (e.g., optionally substituted 5- to 15-membered nitrogen-containing fused heterocyclylene), optionally substituted C 6-10 arylene, or optionally substituted 5- to 20-membered heteroarylene (e.g., optionally substituted 5- to 15-membered heteroarylene), wherein the C 3-20 cycloalkylene, the 4- to 20-membered nitrogen-containing monocyclic heterocyclylene, the 5- to 20-membered nitrogen-containing bridged heterocyclylene, the 5- to 20-membered nitrogen-containing spiro-heterocyclylene, the 5- to 20-membered nitrogen-containing fused heterocyclylene, the C 6-10 arylene, and the 5- to 20-membered heteroarylene are each independently optionally substituted with one or more (e.g., 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C 1-4 alkyl (e.g., optionally deuterated C 1-3 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), hydroxy, amino, mercapto, halogen, cyano, C 1-4 alkoxy (e.g., C 1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C 1-4 alkyl-NH- (e.g., C 1-3 alkyl-NH-, such as CH 3 NH-, CH 3 CH 2 NH- or CH 3 CH 2 CH 2 NH-), halogenated C 1-4 alkyl (e.g., halogenated C 1-3 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), NH 2 -C 1-4 alkylene (e.g., NH 2 -C 1-3 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - andNH 2 CH 2 CH 2 CH 2 -), C 1-4 alkyl-NHC(O)- (e.g., C 1-3 alkyl-NHC(O)-, such as CH 3 -NHC(O)-, CH 3 CH 2 -NHC(O)-, and CH 3 CH 2 CH 2 -NHC(O)-), C 1-4 alkyl-C(O)NH- (e.g., C 1-3 alkyl-C(O)NH-, such as CH 3 -C(O)NH-, CH 3 CH 2 -C(O)NH-, and CH 3 CH 2 CH 2 -C(O)NH-), or any combination thereof. In embodiments of the present disclosure, the number of substituents is not theoretically limited in any way or automatically limited by the size of the building units.

[0022] In some embodiments of the compound of Formula (I-1), R a1 represents: NR d4 R d5 , C(O)NR d6 R d7 , NHC(O)R d8 , NHC(O)NR d9 R d10 , C(O)OR d11 , OC(O)R d12 , OR d13 , SR d14 , C(O)R d15 , C(S)R d16 , S(O)R d17 , S(O) 2 R d18 , S(O) 2 NHR d19 , NHS(O) 2 R d20 , S(O) 2 OR d21 , OS(O) 2 Rd 22 , optionally substituted linear or branched C 1-10 alkyl, optionally substituted C 3-20 cycloalkyl, optionally substituted 4- to 20-membered heterocyclyl, optionally substituted C 6-20 aryl or optionally substituted 5- to 20-membered heteroaryl, wherein the linear or branched C 1-10 alkyl, the C 3-20 cycloalkyl, the 4- to 20-membered heterocyclyl, the C 6-20 aryl or the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C 1-4 alkyl (e.g., optionally deuterated C 1-3 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), hydroxy, amino, mercapto, halogen, cyano, C 1-4 alkoxy (e.g., C 1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C 1-4 alkyl-NH- (e.g., C 1-3 alkyl-NH-, such as CH 3 NH-, CH 3 CH 2 NH- or CH 3 CH 2 CH 2 NH-), halogenated C 1-4 alkyl (e.g., halogenated C 1-3 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), NH 2 -C 1-4 alkylene (e.g., NH 2 -C 1-3 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - and NH 2 CH 2 CH 2 CH 2 -), C 1-4 alkyl-NHC(O)- (e.g., C 1-3 alkyl-NHC(O)-, such as CH 3 -NHC(O)-, CH 3 CH 2 -NHC(O)-, and CH 3 CH 2 CH 2 -NHC(O)-), C 1-4 alkyl-C(O)NH- (e.g., C 1-3 alkyl-C(O)NH-, such as CH 3 -C(O)NH-, CH 3 CH 2 -C(O)NH-, and CH 3 CH 2 CH 2 -C(O)NH-), optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof; wherein R d4 , R d5 , R d6 , R d7 , R d9 , R d10 , R d11 , R d13 , R d14 , R d19 and R d21 each independently represent H, optionally substituted linear or branched C 1-10 alkyl, optionally substituted C 3-20 cycloalkyl, optionally substituted C 6-20 aryl, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted 5- to 20-membered heteroaryl, wherein the linear or branched C 1-10 alkyl, the C 3-20 cycloalkyl, the 4- to 20-membered heterocyclyl, the C 6-20 aryl or the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C 1-4 alkyl (e.g., optionally deuterated C 1-3 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), hydroxy, amino, mercapto, halogen, cyano, C 1-4 alkoxy (e.g., C 1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C 1-4 alkyl-NH- (e.g., C 1-3 alkyl-NH-, such as CH 3 NH-, CH 3 CH 2 NH- or CH 3 CH 2 CH 2 NH-), halogenated C 1-4 alkyl (e.g., halogenated C 1-3 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), NH 2 -C 1-4 alkylene (e.g., NH 2 -C 1-3 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - and NH 2 CH 2 CH 2 CH 2 -), C 1-4 alkyl-NHC(O)- (e.g., C 1-3 alkyl-NHC(O)-, such as CH 3 -NHC(O)-, CH 3 CH 2 -NHC(O)-, and CH 3 CH 2 CH 2 -NHC(O)-), C 1-4 alkyl-C(O)NH-(e.g., C 1-3 alkyl-C(O)NH-, such as CH 3 -C(O)NH-, CH 3 CH 2 -C(O)NH-, and CH 3 CH 2 CH 2 -C(O)NH-), optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof; and R d8 , R d12 , R d15 , R d16 , R d17 , Rais, R d20 and R d22 each independently represent optionally substituted linear or branched C 1-10 alkyl, optionally substituted C 3-20 cycloalkyl, optionally substituted 4- to 20-membered heterocyclyl, optionally substituted C 6-20 aryl or optionally substituted 5- to 20-membered heteroaryl, wherein the linear or branched C 1-10 alkyl, the C 3-20 cycloalkyl, the 4- to 20-membered heterocyclyl, the C 6-20 aryl or the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C 1-4 alkyl (e.g., optionally deuterated C 1-3 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), halogenated C 1-4 alkyl (e.g., halogenated C 1-3 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), hydroxy, amino, mercapto, halogen, cyano, C 1-4 alkoxy (e.g., C 1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C 1-4 alkyl-NH-(e.g., C 1-3 alkyl-NH-, such as CH 3 NH-, CH 3 CH 2 NH- or CH 3 CH 2 CH 2 NH-), NH 2 -C 1-4 alkylene (e.g., NH 2 -C 1-3 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - and NH 2 CH 2 CH 2 CH 2 -), C 1-4 alkyl-NHC(O)- (e.g., C 1-3 alkyl-NHC(O)-, such as CH 3 -NHC(O)-, CH 3 CH 2 -NHC(O)-, and CH 3 CH 2 CH 2 -NHC(O)-), C 1-4 alkyl-C(O)NH- (e.g., C 1-3 alkyl-C(O)NH-, such as CH 3 -C(O)NH-, CH 3 CH 2 -C(O)NH-, and CH 3 CH 2 CH 2 -C(O)NH-), optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof. In embodiments of the present disclosure, the number of substituents is not theoretically limited in any way or automatically limited by the size of the building units.

[0023] In some embodiments of the compound of Formula (I-1), X 1 represents: cyclopropylene, cyclobutylene, cyclopentylene, cyclopentenylene, cyclohexylene, cyclohexenylene, cycloheptylene, cyclooctylene, decalinylene, octahydropentalenylene, octahydro-1H-indenylene, spiro[3.3]heptylene, spiro[2.5]octylene, spiro[3.5]nonylene, spiro[4.4]nonylene, spiro[4.5]decylene, spiro[5.5]undecylene, p-menthanylene, m-menthanylene, quinuclidinylene, adamantanylene, noradamantanylene, bornylene, bicyclo[2.2.1]heptanylene, 2-oxobicyclo[2.2.1]heptanylene or bicyclo[2.2.1]heptenylene, with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C 1-4 alkyl, halogenated C 1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C 1-4 alkoxy, C 1-4 alkyl-NH-, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, or any combination thereof; phenylene or naphthylene, wherein the phenylene or naphthylene is optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C 1-4 alkyl, halogenated C 1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C 1-4 alkoxy, C 1-4 alkyl-NH-, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, or any combination thereof; azetidinylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, oxazolidinylene, thiazolidinylene, piperidinylene, piperazinylene, morpholinylene, thiomorpholinylene, azepanylene, azacyclooctylene, diazacycloheptanylene, diazacyclooctylene, 3-azabicyclo[3.1.0]hexylene, 6-azabicyclo[3.1.1]heptanylene, 2,5-diazabicyclo[2.2.1]heptanylene, 3,6-diazabicyclo[3.1.1]heptanylene, 3-azabicyclo[3.2.1]octylene, 3,8-diazabicyclo[3.2.1]octylene, 2,5-diazabicyclo[2.2.2]octylene, 3-azaspiro[5.5]undecylene or 7-azaspiro[3.5]nonylene, with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C 1-4 alkyl, halogenated C 1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C 1-4 alkoxy, C 1-4 alkyl-NH-, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, or any combination thereof; or furanylene, oxazolylene, isoxazolylene, oxadiazolylene, thienylene, thiazolylene, isothiazolylene, thiadiazolylene, pyrrolylene, imidazolylene, pyrazolylene, triazolylene, pyridylene, pyrimidinylene, pyridazinylene, pyrazinylene, indolylene, isoindolylene, benzofuranylene, isobenzofuranylene, benzothienylene, indazolylene, benzimidazolylene, benzoxazolylene, benzisoxazolylene, benzothiazolylene, benzisothiazolylene, benzotriazolylene, benzo[2,1,3]oxadiazolylene, benzo[2,1,3]thiadiazolylene, benzo[1,2,3]thiadiazolylene, quinolinylene, isoquinolinylene, naphthyridinylene, cinnolinylene, quinazolinylene, quinoxalinylene, phthalazinylene, pyrazolo[1,5-a]pyridylene, pyrazolo[1,5-a]pyrimidinylene, imidazo[1,2-a]pyridylene, 1H-pyrrolo[3,2-b]pyridylene, 1H-pyrrolo[2,3-b]pyridylene, 4H-fluoro[3,2-b]pyrrolylene, pyrrolo[2,1-b]thiazolylene and imidazo[2,1-b]thiazolylene, with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C 1-4 alkyl, halogenated C 1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C 1-4 alkoxy, C 1-4 alkyl-NH-, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, or any combination thereof. In embodiments of the present disclosure, the number of substituents is not theoretically limited in any way or automatically limited by the size of the building units.

[0024] In some embodiments of the compound of Formula (I-1), R a1 represents NR d4 R d5 , C(O)NR d6 R d7 , NHC(O)R d8 , NHC(O)NR d9 R d10 , C(O)OR d11 , OC(O)R d12 , OR d13 , SR d14 , C(O)R d15 , C(S)R d16 , S(O)R d17 , S(O) 2 R d18 , S(O) 2 NHR d19 , NHS(O) 2 R d20 , S(O) 2 OR d21 , or OS(O) 2 R d22 , wherein R d4 , R d5 , R d6 , R d7 , R d9 , R d10 , R d11 , R d13 , R d14 , R d19 and R d21 are the same or different and each independently represent: H, or methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, pentyl, isopentyl, neopentyl, tert-pentyl, hexyl, heptyl, octyl, nonyl or decyl, with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C 1-4 alkyl, halogen, hydroxy, cyano, amino, mercapto, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene or any combination thereof; or cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptanyl, or bicyclo[2.2.1]heptenyl, with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C 1-4 alkyl, halogen, hydroxy, cyano, amino, mercapto, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4-to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene or any combination thereof; or phenyl or naphthyl, with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of optionally deuterated C 1-4 alkyl, halogen, hydroxy, cyano, amino, mercapto, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene or any combination thereof; or azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octyl, 2,5-diazabicyclo[2.2.2]octyl, or azaspirocycloalkyl (e.g., 3-azaspiro[5.5]undecyl or 7-azaspiro[3.5]nonyl), with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C 1-4 alkyl, halogen, hydroxy, cyano, amino, mercapto, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene or any combination thereof; furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl or imidazo[2,1-b]thiazolyl, with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C 1-4 alkyl, halogen, hydroxy, cyano, amino, mercapto, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene or any combination thereof; and R d8 , R d12 , R d15 , R d16 , R d17 , Rais, R d20 and R d22 each independently represent: methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, pentyl, isopentyl, neopentyl, tert-pentyl, hexyl, heptyl, octyl, nonyl or decyl, with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene or any combination thereof; or cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptanyl, or bicyclo[2.2.1]heptenyl, with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene or any combination thereof; or phenyl or naphthyl, with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of halogen, hydroxy, cyano, amino, mercapto, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene or any combination thereof; or azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octyl, 2,5-diazabicyclo[2.2.2]octyl, or azaspirocycloalkyl (e.g., 3-azaspiro[5.5]undecyl or 7-azaspiro[3.5]nonyl), with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene or any combination thereof; furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl or imidazo[2,1-b]thiazolyl, with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene or any combination thereof;

[0025] In some embodiments of the compound of Formula (I-1), R a1 represents: methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, pentyl, isopentyl, neopentyl, tert-pentyl, hexyl, heptyl, octyl, nonyl or decyl, with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4-to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene or any combination thereof; or cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptanyl, or bicyclo[2.2.1]heptenyl, with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene or any combination thereof; or phenyl or naphthyl, with each group being optionally substituted with one or more (e.g., 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of halogen, hydroxy, cyano, amino, mercapto, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene or any combination thereof; or azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octyl, 2,5-diazabicyclo[2.2.2]octyl, or azaspirocycloalkyl (e.g., 3-azaspiro[5.5]undecyl or 7-azaspiro[3.5]nonyl), with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4-to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene or any combination thereof; or furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl or imidazo[2,1-b]thiazolyl, with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C 3-15 cycloalkyl, optionally substituted C 6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene or any combination thereof. In embodiments of the present disclosure, the number of substituents is not theoretically limited in any way or automatically limited by the size of the building units.

[0026] In some embodiments of the compound of Formula (I-1), X 1 represents: wherein symbol # indicates the point of attachment to L 1 .

[0027] In some embodiments of the compound of Formula (I-1), R a1 represents hydroxy.

[0028] In some embodiments of the compound of Formula (I-1), R a1 represents: or

[0029] In some embodiments of the compound of Formula (I-1), L 1 represents the structure of the following formula:         ##-(C(R a1< )(R a2< )) m1 -(R d1 (C(R a3< )(R a4< )) m2 ) p1 -;         ##-(C(R a1< )(R a2< )) m1 -(R d1 (C(R a3< )(R a4< )) m2 ) p1 -(R d1 (C(R a5< )(R a6< )) m3 ) p2 -;         ##-(C(R a1< )(R a2< )) m1 -(R d1 (C(R a3< )(R a4< )) m2 ) p1 -(R d1 (C(R a5< )(R a6< )) m3 ) p2 -(R d1 (C(R a7< )(R a8< )) m4 ) p3 -;         ##-(C(R a1< )(R a2< )) m1 -(R d2 (C(R a3< )(R a4< )) m2 ) p1 -;         ##-(C(R a1< )(R a2< )) m1 -(R d2 (C(R a3< )(R a4< )) m2 ) p1 -(R d2 (C(R a5< )(R a6< )) m3 ) p2 -;         ##-(C(R a1< )(R a2< )) m1 -(R d2 (C(R a3< )(R a4< )) m2 ) p1 -(R d2 (C(R a5< )(R a6< ) m3 ) p2 (R d2 (C(R a7< )(R a8< ) m4 ) p3 -;         ##-(C(R a1< )(R a2< )) m1 -(R d1 -R d2 -(C(R a3< )(R a4< )) m2 ) p1 -;         ##-(C(R a1< )(R a2< )) m1 -(R d1 (C(R a3< )(R a4< )) m2 ) p1 -(R d2 (C(R a5< )(R a6< )) m3 ) p2 -;         ##-(C(R a1< )(R a2< )) m1 -(R d2 -R d1 -(C(R a3< )(R a4< )) m2 ) p1 -; or         ##-(C(R a1< )(R a2< )) m1 -(R d2 (C(R a3< )(R a4< )) m2 ) p1 -(R d1 (C(R a5< )(R a6< )) m3 ) p2 -; wherein each group R d1 is independently selected from the group consisting of O, S, N(R d3 ), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O) 2 , S(O) 2 O, OS(O) 2 , S(O) 2 NH or NHS(O) 2 , wherein each R d3 independently represents H or C 1-3 alkyl; each group R d2 is independently selected from the group consisting of optionally substituted C 3-15 cycloalkylene, optionally substituted 4- to 15-membered heterocyclylene, optionally substituted C 6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C 2-6 alkenylene, C 2-6 alkynylene or any combination thereof, wherein the C 3-15 cycloalkylene, the C 6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C 1-6 alkyl (e.g., optionally deuterated C 1-4 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C 3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 alkoxy (e.g., C 1-3 alkoxy, such as methoxy, ethoxy, or propoxy), optionally deuterated C 1-6 alkyl-NH- (e.g., C 1-3 alkyl-NH-, such as CH 3 NH-, CH 3 CH 2 NH- or CH 3 CH 2 CH 2 NH-), halogenated C 1-6 alkyl halogenated C 1-4 alkyl (e.g., halogenated C 1-3 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), NH 2 -C 1-6 alkylene (e.g., NH 2 -C 1-3 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - and NH 2 CH 2 CH 2 CH 2 -), optionally deuterated C 1-6 alkyl-NHC(O)- (e.g., C 1-3 alkyl-NHC(O)-, such as CH 3 -NHC(O)-, CH 3 CH 2 -NHC(O)-, and CH 3 CH 2 CH 2 -NHC(O)-), optionally deuterated C 1-6 alkyl-C(O)NH-(e.g., C 1-3 alkyl-C(O)NH-, such as CH 3 -C(O)NH-, CH 3 CH 2 -C(O)NH-, and CH 3 CH 2 CH 2 -C(O)NH-) or any combination thereof; R a1< , R a2< , R a3< , R a4< , R a5< , R a6< , R a7< and R a8< each independently represent H, deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C 1-6 alkyl (e.g., optionally deuterated C 1-4 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), halogenated C 1-6 alkyl halogenated C 1-4 alkyl (e.g., halogenated C 1-3 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), optionally deuterated C 3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), optionally deuterated C 1-6 alkoxy (e.g., C 1-3 alkoxy, such as methoxy, ethoxy, or propoxy), optionally deuterated C 1-6 alkyl-NH- (e.g., C 1-3 alkyl-NH-, such as CH 3 NH-, CH 3 CH 2 NH- or CH 3 CH 2 CH 2 NH-), NH 2 -C 1-6 alkylene (e.g., NH 2 -C 1-3 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - and NH 2 CH 2 CH 2 CH 2 -), optionally deuterated C 1-6 alkyl-NHC(O)- (e.g., C 1-3 alkyl-NHC(O)-, such as CH 3 -NHC(O)-, CH 3 CH 2 -NHC(O)-, and CH 3 CH 2 CH 2 -NHC(O)-), optionally deuterated C 1-6 alkyl-C(O)NH- (e.g., C 1-3 alkyl-C(O)NH-, such as CH 3 -C(O)NH-, CH 3 CH 2 -C(O)NH-, and CH 3 CH 2 CH 2 -C(O)NH-) or any combination thereof; symbol ## indicates the point of attachment to X 1 ; and m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

[0030] In some embodiments of the compound of Formula (I-1), L 1 represents the structure of the following formula:         ##-(C(R a1< )(R a2< )) m1 -(O(C(R a3< )(R a4< )) m2 ) p1 -;         ##-(C(R a1< )(R a2< )) m1 -(O(C(R a3< )(R a4< )) m2 ) p1 -(O(C(R a5< )(R a6< )) m3 ) p2 -;         ##-(C(R a1< )(R a2< )) m1 -(O(C(R a3< )(R a4< )) m2 ) p1 -(O(C(R a5< )(R a6< )) m3 ) p2 -(O(C(R a7< )(R a8< )) m4 ) p3 -; ##-(C(R a1< )(R a2< )) m1 -(N(R g9 )(C(R a3< )(R a4< )) m2 ) p1 -;         ##-(C(R a1< )(R a2< )) m1 -(N(R g9 )(C(R a3< )(R a4< )) m2 ) p1 -(N(R g9 )(C(R a5< )(R a6< )) m3 ) p2 -;         ##-(C(R a1< )(R a2< )) m1 -(N(R g9 )(C(R a3< )(R a4< )) m2 ) p1 -(N(R g9 )(C(R a5< )(R a6< )) m3 ) p2 -(N(R g9 )(C(R a7< )(R a8< )) m4 ) p3 -;         ##-(C(R a1< )(R a2< )) m1 -(C(O)NH-(C(R a3< )(R a4< )) m2 ) p1 -;         ##-(C(R a1< )(R a2< )) m1 -(C(O)NH-(C(R a3< )(R a4< )) m2 ) p1 -(C(O)NH-(C(R a5< )(R a6< )) m3 ) p2 -;         ##-(C(R a1< )(R a2< )) m1 -(C(O)NH-(C(R a3< )(R a4< )) m2 ) p1 -(C(O)NH-(C(R a5< )(R a6< )) m3 ) p2 -(C(O)NH-)(C(R a7< )(R a8< )) m4 ) p3 -;         ##-(C(R a1< )(R a2< )) m1 -(C(O)NH-(C(R a3< )(R a4< )) m2 ) p1 -(O-(C(R a5< )(R a6< )) m3 ) p2 -;         ##-(C(R a1< )(R a2< )) m1 -(C(O)NH-(C(R a3< )(R a4< )) m2 )-(O-(C(R a5< )(R a6< )) m3 ) p1 -;         ##-(C(R a1< )(R a2< )) m1 -(NHC(O)-(C(R a3< )(R a4< )) m2 ) p1 -;         ##-(C(R a1< )(R a2< )) m1 -(NHC(O)-(C(R a3< )(R a4< )) m2 ) p1 -(O-(C(R a5< )(R a6< )) m3 ) p2 -;         ##-(C(R a1< )(R a2< )) m1 -(NHC(O)-(C(R a3< )(R a4< )) m2 ) p1 -(O)-(C(R a5< )(R a6< )) m3 ) p2 -(O)(C(R a7< )(R a8< )) m4 ) p3 -;         ##-(C(R a1< )(R a2< )) m1 -NHC(O)-(C(R a3< )(R a4< )) m2 ) p1 -(O-(C(R a5< )(R a6< )) m3 ) p1 -;         ##-(C(R a1< )(R a2< )) m1 -NHC(O)NH-(C(R a3< )(R a4< )) m2 -;         ##-(C(R a1< )(R a2< )) m1 -C(O)-(C(R a3< )(R a4< )) m2 -;         ##-(C(R a1< )(R a2< )) m1 -C(S)-(C(R a3< )(R a4< )) m2 -;         ##-(C(R a1< )(R a2< )) m1 -S-(C(R a3< )(R a4< )) m2 -;         ##-(C(R a1< )(R a2< )) m1 -C 6-10 arylene-(C(R a3< )(R a4< )) m2 ) p1 -;         ##-(C(R a1< )(R a2< )) m1 -C 6-10 arylene-(C(R a3< )(R a4< )) m2 ) p1 -C 6-10 arylene-(C(R a5< )(R a6< )) m3 -;         ##-(C(R a1< )(R a2< )) m1 -(4- to 15-membered heterocyclylene-(C(R a3< )(R a4< )) m2 ) p1 -;         ##-(C(R a1< )(R a2< )) m1 -(4- to 15-membered heterocyclylene-(C(R a3< )(R aa< )) m2 ) p1 -(4- to 15-membered heterocyclylene-(C(R a5< )(R a6< )) m3 ) p2 -;         ###-(C(R a1< )(R a2< )) m1 -(5- to 15-membered heteroarylene-(C(R a3< )(R a4< )) m2 ) p1 -;         ##-(C(R a1< )(R a2< )) m1 -(5- to 15-membered heteroarylene-(C(R a3< )(R a4< )) m2 ) p1 -(5- to 15-membered heteroarylene-(C(R a5< )(R a6< )) m3 ) P2 -;         ##-(C(R a1< )(R a2< )) m1 -(C 3-15 cycloalkylene-(C(R a3< )(R a4< )) m2 ) p1 -; or         ##-(C(R a1< )(R a2< )) m1 -(C 3-15 cycloalkylene-(C(R a< 3)(R a4< )) m2 ) p1 -(C 3-15 cycloalkylene-(C(R a5< )(R a< 6)) m3 ) p2 -; wherein each R g9 independently represents H or C 1-3 alkyl; the C 3-15 cycloalkylene, the C 6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, optionally deuterated C 1-6 alkoxy, optionally deuterated C 1-6 alkyl-NH-, halogenated C 1-6 alkyl, NH 2 -C 1-6 alkylene, optionally deuterated C 1-6 alkyl-NHC(O)-, optionally deuterated C 1-6 alkyl-C(O)NH-, cyano or any combination thereof; R a1< , R a2< , R a3< , R a4< , R a5< , R a6< , R a7< and R a8< each independently represent H, deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C 1-6 alkyl, halogenated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, optionally deuterated C 1-6 alkoxy, optionally deuterated C 1-6 alkyl-NH-, NH 2 -C 1-6 alkylene, optionally deuterated C 1-6 alkyl-NHC(O)-, optionally deuterated C 1-6 alkyl-C(O)NH- or any combination thereof; symbol ## indicates the point of attachment to X 1 ; and m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

[0031] In some embodiments of the compound of Formula (I-1), L 1 represents the following group: ##-CH 2 -O-CH 2 -, ##-CH 2 -O-(CH 2 ) 2 -, ##-(CH 2 ) 1 -O-(CH 2 ) 3 -, ##-(CH 2 ) 1 -O-(CH 2 ) 4 -, ##-(CH 2 ) 1 -O-(CH 2 ) 5 -, ##-(CH 2 ) 1 -O-(CH 2 ) 6 -, ##-(CH 2 ) 1 -O-(CH 2 ) 7 -, ##-(CH 2 ) 1 -O-(CH 2 ) 8 -, ##-(CH 2 ) 1 -O-(CH 2 ) 9 -, ##-(CH 2 ) 1 -O-(CH 2 ) 10 -, ##-(CH 2 ) 2 -O-(CH 2 ) 1 -, ##-(CH 2 ) 2 -O-(CH 2 ) 2 -, ##-(CH 2 ) 2 -O-(CH 2 ) 3 -, ##-(CH 2 ) 2 -O-(CH 2 ) 4 -, ##-(CH 2 ) 2 -O-(CH 2 ) 5 -, ##-(CH 2 ) 2 -O-(CH 2 ) 6 -, ##-(CH 2 ) 2 -O-(CH 2 ) 7 -, ##-(CH 2 ) 2 -O-(CH 2 ) 8 -, ##-(CH 2 ) 2 -O-(CH 2 ) 9 -, ##-(CH 2 ) 2 O-(CH 2 ) 10 -, ##-(CH 2 ) 2 -O-(CH 2 ) 11 -, ##-(CH 2 ) 2 -O-(CH 2 ) 12 -, ##-(CH 2 ) 3 -O-(CH 2 ) 1 -, ##-(CH 2 ) 3 -O-(CH 2 ) 2 -, ##-(CH 2 ) 3 -O-(CH 2 ) 3 -, ##-(CH 2 ) 3 -O-(CH 2 ) 4 -, ##-(CH 2 ) 3 -O-(CH 2 ) 5 -, ##-(CH 2 ) 3 -O-(CH 2 ) 6 -, ##-(CH 2 ) 3 -O-(CH 2 ) 7 -, ##-(CH 2 ) 4 -O-(CH 2 ) 1 -, ##-(CH 2 ) 4 -O-(CH 2 ) 2 -, ##-(CH 2 ) 4 -O-(CH 2 ) 3 -, ##-(CH 2 ) 4 -O-(CH 2 ) 4 -, ##-(CH 2 ) 4 -O-(CH 2 ) 5 -, ##-(CH 2 ) 4 -O-(CH 2 ) 6 -, ##-(CH 2 ) 5 -O-(CH 2 ) 1 -, ##-(CH 2 ) 5 -O-(CH 2 ) 2 -, ##-(CH 2 ) 5 -O-(CH 2 ) 3 -, ##-(CH 2 ) 5 -O-(CH 2 ) 4 -, ##-(CH 2 ) 5 -O-(CH 2 ) 5 -, ##-(CH 2 ) 6 -O-(CH 2 ) 1 -, ##-(CH 2 ) 6 -O-(CH 2 ) 2 -, ##-(CH 2 ) 6 -O-(CH 2 ) 3 -, ##-(CH 2 ) 6 -O-(CH 2 ) 4 -, ##-(CH 2 ) 7 -O-(CH 2 ) 1 -, ##-(CH 2 ) 7 -O-(CH 2 ) 2 -, ##-(CH 2 ) 7 -O-(CH 2 ) 3 -, ##-(CH 2 ) 8 -O-(CH 2 ) 1 -, ##-(CH 2 ) 8 -O-(CH 2 ) 2 -, ##-CH(CH 3 )-O-(CH 2 ) 1 -, ##-CH(CH 3 )-O-(CH 2 ) 2 -, ##-CH(CH 3 )-O-(CH 2 ) 3 -, ##-CH(CH 3 )-O-(CH 2 ) 4 -, ##-CH(CH 3 )-O-(CH 2 ) 5 -, ##-CH(CH 3 )-O-(CH 2 ) 6 -, ##-CH(CH 3 )-O-(CH 2 ) 7 -, ##-CH(CH 3 )-O-(CH 2 ) 8 -, ##-CH(CH 3 )-O-(CH 2 ) 9 -, ##-CH(CH 3 )-O-(CH 2 ) 10 -, ##-CH 2 -(O(CH 2 ) 2 ) 2 -, ##-CH 2 -(O(CH 2 ) 2 ) 3 -, ##-CH 2 -(O(CH 2 ) 2 ) 4 -, ##-CH 2 -(O(CH 2 ) 2 ) 5 -, ##-CH 2 -(O(CH 2 ) 2 ) 6 -, ##-CH 2 -(O(CH 2 ) 2 ) 7 -, ##-CH 2 -(O(CH 2 ) 2 ) 8 -, ##-CH 2 -(O(CH 2 ) 2 ) 9 -, ##-CH 2 -(O(CH 2 ) 2 ) 10 -, ##-CH 2 -(O(CH 2 ) 2 ) 1 -OCH 2 -, ##-CH 2 -(O(CH 2 ) 2 ) 2 -OCH 2 -, ##-CH 2 -(O(CH 2 ) 2 ) 3 -OCH 2 -, ##-CH 2 -(O(CH 2 ) 2 ) 4 -OCH 2 -, ##-CH 2 -(O(CH 2 ) 2 ) 5 -OCH 2 -, ##-CH 2 -(O(CH 2 ) 2 ) 6 -OCH 2 -, ##-CH 2 -(O(CH 2 ) 2 ) 7 -OCH 2 -, ##-CH 2 -(O(CH 2 ) 2 ) 8 -OCH 2 -, ##-CH 2 -(O(CH 2 ) 2 ) 9 -OCH 2 -, ##-CH 2 -(O(CH 2 ) 2 ) 10 -OCH 2 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 2 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 3 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 4 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 5 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 6 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 7 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 8 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 9 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 10 -, ##-(CH 2 ) 3 -(O(CH 2 ) 2 ) 2 -, ##-(CH 2 ) 3 -(O(CH 2 ) 2 ) 3 -, ##-(CH 2 ) 3 -(O(CH 2 ) 2 ) 4 -, ##-(CH 2 ) 3 -(O(CH 2 ) 2 ) 5 -, ##-(CH 2 ) 3 -(O(CH 2 ) 2 ) 6 -, ##-(CH 2 ) 3 -(O(CH 2 ) 2 ) 7 -, ##-(CH 2 ) 3 -(O(CH 2 ) 2 ) 8 -, ##-(CH 2 ) 3 -(O(CH 2 ) 2 ) 9 -, ##-(CH 2 ) 3 -(O(CH 2 ) 2 ) 10 -, ##-(CH 2 ) 4 -(O(CH 2 ) 2 ) 2 -, ##-(CH 2 ) 4 -(O(CH 2 ) 2 ) 3 -, ##-(CH 2 ) 4 -(O(CH 2 ) 2 ) 4 -, ##-(CH 2 ) 4 -(O(CH 2 ) 2 ) 5 -, ##-(CH 2 ) 4 -(O(CH 2 ) 2 ) 6 -, ##-(CH 2 ) 4 -(O(CH 2 ) 2 ) 7 -, ##-(CH 2 ) 4 -(O(CH 2 ) 2 ) 8 -, ##-(CH 2 ) 4 -(O(CH 2 ) 2 ) 9 -, ##-(CH 2 ) 4 -(O(CH 2 ) 2 ) 10 -, ##-CH 2 -(O(CH 2 ) 3 ) 2 -, ##-CH 2 -(O(CH 2 ) 3 ) 3 -, ##-CH 2 -(O(CH 2 ) 3 ) 4 -, ##-CH 2 -(O(CH 2 ) 3 ) 5 -, ##-CH 2 -(O(CH 2 ) 3 ) 6 -, ##-CH 2 -(O(CH 2 ) 3 ) 7 -, ##-CH 2 -(O(CH 2 ) 3 ) 8 -, ##-CH 2 -(O(CH 2 ) 3 ) 9 -, ##-CH 2 -(O(CH 2 ) 3 ) 10 -, ##-(CH 2 ) 2 -(O(CH 2 ) 3 ) 2 -, ##-(CH 2 ) 2 -(O(CH 2 ) 3 ) 3 -, ##-(CH 2 ) 2 -(O(CH 2 ) 3 ) 4 -, ##-(CH 2 ) 2 -(O(CH 2 ) 3 ) 5 -, ##-(CH 2 ) 2 -(O(CH 2 ) 3 ) 6 -, ##-(CH 2 ) 2 -(O(CH 2 ) 3 ) 7 -, ##-(CH 2 ) 2 -(O(CH 2 ) 3 ) 8 -, ##-(CH 2 ) 2 -(O(CH 2 ) 3 ) 9 -, ##-(CH 2 ) 2 -(O(CH 2 ) 3 ) 10 -, ##-(CH 2 ) 3 -(O(CH 2 ) 3 ) 2 -, ##-(CH 2 ) 3 -(O(CH 2 ) 3 ) 3 -, ##-(CH 2 ) 3 -(O(CH 2 ) 3 ) 4 -, ##-(CH 2 ) 3 -(O(CH 2 ) 3 ) 5 -, ##-(CH 2 ) 3 -(O(CH 2 ) 3 ) 6 -, ##-(CH 2 ) 3 -(O(CH 2 ) 3 ) 7 -, ##-(CH 2 ) 3 -(O(CH 2 ) 3 ) 8 -, ##-(CH 2 ) 3 -(O(CH 2 ) 3 ) 9 -, ##-(CH 2 ) 3 -(O(CH 2 ) 3 ) 10 -, ##-CH 2 -O-(CH 2 ) 2 -O-(CH 2 ) 3 -, ##-CH 2 -(O(CH 2 ) 2 ) 2 -(O(CH 2 ) 3 ) 2 -, ##-CH 2 -(O(CH 2 ) 2 ) 3 -(O(CH 2 ) 3 ) 3 -, ##-CH 2 -(O(CH 2 ) 2 ) 4 -(O(CH 2 ) 3 ) 4 -, ##-CH 2 -(O(CH 2 ) 2 ) 5 -(O(CH 2 ) 3 ) 5 -, ##-CH 2 -(O(CH 2 ) 2 ) 6 -(O(CH 2 ) 3 ) 6 -, ##-(CH 2 ) 2 -O-(CH 2 ) 2 -O-(CH 2 ) 3 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 2 -(O(CH 2 ) 3 ) 2 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 3 -(O(CH 2 ) 3 ) 3 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 4 -(O(CH 2 ) 3 ) 4 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 5 -(O(CH 2 ) 3 ) 5 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 6 -(O(CH 2 ) 3 ) 6 -, ##-(CH 2 ) 3 -O-(CH 2 ) 2 -O-(CH 2 ) 3 -, ##-(CH 2 ) 3 -(O(CH 2 ) 2 ) 2 -(O(CH 2 ) 3 ) 2 -, ##-(CH 2 ) 3 -(O(CH 2 ) 2 ) 3 -(O(CH 2 ) 3 ) 3 -, ##-(CH 2 ) 3 -(O(CH 2 ) 2 ) 4 -(O(CH 2 ) 3 ) 4 -, ##-(CH 2 ) 3 -(O(CH 2 ) 2 ) 5 -(O(CH 2 ) 3 ) 5 -, ##-(CH 2 ) 3 -(O(CH 2 ) 2 ) 6 -(O(CH 2 ) 3 ) 6 -, ##-CH 2 -O-(CH 2 ) 3 -O-(CH 2 ) 2 -, ##-CH 2 -(O(CH 2 ) 3 ) 2 -(O(CH 2 ) 2 ) 2 -, ##-CH 2 -(O(CH 2 ) 3 ) 3 -(O(CH 2 ) 2 ) 3 -, ##-CH 2 -(O(CH 2 ) 3 ) 4 -(O(CH 2 ) 2 ) 4 -, ##-CH 2 -(O(CH 2 ) 3 ) 5 -(O(CH 2 ) 2 ) 5 -, ##-CH 2 -(O(CH 2 ) 3 ) 6 -(O(CH 2 ) 2 ) 6 -, ##-(CH 2 ) 2 -O-(CH 2 ) 3 -O-(CH 2 ) 2 -, ##-(CH 2 ) 2 -(O(CH 2 ) 3 ) 2 -(O(CH 2 ) 2 ) 2 -, ##-(CH 2 ) 2 -(O(CH 2 ) 3 ) 3 -(O(CH 2 ) 2 ) 3 -, ##-(CH 2 ) 2 -(O(CH 2 ) 3 ) 4 -(O(CH 2 ) 2 ) 4 -, ##-(CH 2 ) 2 -(O(CH 2 ) 3 ) 5 -(O(CH 2 ) 2 ) 5 -, ##-(CH 2 ) 2 -(O(CH 2 ) 3 ) 6 -(O(CH 2 ) 2 ) 6 -, ##-(CH 2 ) 3 -O-(CH 2 ) 3 -O-(CH 2 ) 2 -, ##-(CH 2 ) 3 -(O(CH 2 ) 3 ) 2 -(O(CH 2 ) 2 ) 2 -, ##-(CH 2 ) 3 -(O(CH 2 ) 3 ) 3 -(O(CH 2 ) 2 ) 3 -, ##-(CH 2 ) 3 -(O(CH 2 ) 3 ) 4 -(O(CH 2 ) 2 ) 4 -, ##-(CH 2 ) 3 -(O(CH 2 ) 3 ) 5 -(O(CH 2 ) 2 ) 5 -, ##-(CH 2 ) 3 -(O(CH 2 ) 3 ) 6 -(O(CH 2 ) 2 ) 6 -, ##-CH 2 -O-(CH 2 ) 2 -O-CH 2 -, ##-(CH 2 ) 2 -O-(CH 2 ) 2 -O-CH 2 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 2 -O-(CH 2 ) 3 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 3 -O-(CH 2 ) 3 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 4 -O-(CH 2 ) 3 -, ##-(CH 2 ) 5 -(O(CH 2 ) 2 ) 2 -O-(CH 2 ) 5 -, ##-(CH 2 ) 5 -(O(CH 2 ) 2 ) 2 -O-(CH 2 ) 6 -, ##-CH 2 -C(O)-CH 2 -, ##-CH 2 -C(O)-(CH 2 ) 2 -, ##-(CH 2 ) 1 -C(O)-(CH 2 ) 3 -, ##-(CH 2 ) 1 -C(O)-(CH 2 ) 4 -, ##-(CH 2 ) 1 -C(O)-(CH 2 ) 5 -, ##-(CH 2 ) 1 -C(O)-(CH 2 ) 6 -, ##-(CH 2 ) 1 -C(O)-(CH 2 ) 7 -, ##-(CH 2 ) 1 -C(O)-(CH 2 ) 8 -, ##-(CH 2 ) 1 -C(O)-(CH 2 ) 9 -, ##-(CH 2 ) 1 -C(O)-(CH 2 ) 10 -, ##-(CH 2 ) 2 -C(O)-(CH 2 ) 1 -, ##-(CH 2 ) 2 -C(O)-(CH 2 ) 2 -, ##-(CH 2 ) 2 -C(O)-(CH 2 ) 3 -, ##-(CH 2 ) 2 -C(O)-(CH 2 ) 4 -, ##-(CH 2 ) 2 -C(O)-(CH 2 ) 5 -, ##-(CH 2 ) 2 -C(O)-(CH 2 ) 6 -, ##-(CH 2 ) 2 -C(O)-(CH 2 ) 7 -, ##-(CH 2 ) 2 -C(O)-(CH 2 ) 8 -, ##-(CH 2 ) 2 -C(O)-(CH 2 ) 9 -, ##-(CH 2 ) 2 -C(O)-(CH 2 ) 10 -, ##-(CH 2 ) 2 -C(O)-(CH 2 ) 11 -, ##-(CH 2 ) 2 -C(O)-(CH 2 ) 12 -, ##-(CH 2 ) 3 -C(O)-(CH 2 ) 1 -, ##-(CH 2 ) 3 -C(O)-(CH 2 ) 2 -, ##-(CH 2 ) 3 -C(O)-(CH 2 ) 3 -, ##-(CH 2 ) 3 -C(O)-(CH 2 ) 4 -, ##-(CH 2 ) 3 -C(O)-(CH 2 ) 5 -, ##-(CH 2 ) 3 -C(O)-(CH 2 ) 6 -, ##-(CH 2 ) 3 -C(O)-(CH 2 ) 7 -, ##-(CH 2 ) 4 -C(O)-(CH 2 ) 1 -, ##-(CH 2 ) 4 -C(O)-(CH 2 ) 2 -, ##-(CH 2 ) 4 -C(O)-(CH 2 ) 3 -, ##-(CH 2 ) 4 -C(O)-(CH 2 ) 4 -, ##-(CH 2 ) 4 -C(O)-(CH 2 ) 5 -, ##-(CH 2 ) 4 -C(O)-(CH 2 ) 6 -, ##-(CH 2 ) 5 -C(O)-(CH 2 ) 1 -, ##-(CH 2 ) 5 -C(O)-(CH 2 ) 2 -, ##-(CH 2 ) 5 -C(O)-(CH 2 ) 3 -, ##-(CH 2 ) 5 -C(O)-(CH 2 ) 4 -, ##-(CH 2 ) 5 -C(O)-(CH 2 ) 5 -, ##-(CH 2 ) 6 -C(O)-(CH 2 ) 1 -, ##-(CH 2 ) 6 -C(O)-(CH 2 ) 2 -, ##-(CH 2 ) 6 -C(O)-(CH 2 ) 3 -, ##-(CH 2 ) 6 -C(O)-(CH 2 ) 4 -, ##-(CH 2 ) 7 -C(O)-(CH 2 ) 1 -, ##-(CH 2 ) 7 -C(O)-(CH 2 ) 2 -, ##-(CH 2 ) 7 -C(O)-(CH 2 ) 3 -, ##-(CH 2 ) 8 -C(O)-(CH 2 ) 1 -, ##-(CH 2 ) 8 -C(O)-(CH 2 ) 2 -, ##-CH 2 -S-CH 2 -, ##-CH 2 -S-(CH 2 ) 2 -, ##-(CH 2 ) 1 -S-(CH 2 ) 3 -, ##-(CH 2 ) 1 -S-(CH 2 ) 4 -, ##-(CH 2 ) 1 -S-(CH 2 ) 5 -, ##-(CH 2 ) 1 -S-(CH 2 ) 6 -, ##-(CH 2 ) 1 -S-(CH 2 ) 7 -, ##-(CH 2 ) 1 -S-(CH 2 ) 8 -, ##-(CH 2 ) 1 -S-(CH 2 ) 9 -, ##-(CH 2 ) 1 -S-(CH 2 ) 10 -, ##-(CH 2 ) 2 -S-(CH 2 ) 1 -, ##-(CH 2 ) 2 -S-(CH 2 ) 2 -, ##-(CH 2 ) 2 -S-(CH 2 ) 3 -, ##-(CH 2 ) 2 -S-(CH 2 ) 4 -, ##-(CH 2 ) 2 -S-(CH 2 ) 5 -, ##-(CH 2 ) 2 -S-(CH 2 ) 6 -, ##-(CH 2 ) 2 -S-(CH 2 ) 7 -, ##-(CH 2 ) 2 -S-(CH 2 ) 8 -, ##-(CH 2 ) 2 -S-(CH 2 ) 9 -, ##-(CH 2 ) 2 -S-(CH 2 ) 10 -, ##-(CH 2 ) 2 -S-(CH 2 ) 11 -, ##-(CH 2 ) 2 -S-(CH 2 ) 12 -, ##-(CH 2 ) 3 -S-(CH 2 ) 1 -, ##-(CH 2 ) 3 -S-(CH 2 ) 2 -, ##-(CH 2 ) 3 -S-(CH 2 ) 3 -, ##-(CH 2 ) 3 -S-(CH 2 ) 4 -, ##-(CH 2 ) 3 -S-(CH 2 ) 5 -, ##-(CH 2 ) 3 -S-(CH 2 ) 6 -, ##-(CH 2 ) 3 -S-(CH 2 ) 7 -, ##-(CH 2 ) 4 -S-(CH 2 ) 1 -, ##-(CH 2 ) 4 -S-(CH 2 ) 2 -, ##-(CH 2 ) 4 -S-(CH 2 ) 3 -, ##-(CH 2 ) 4 -S-(CH 2 ) 4 -, ##-(CH 2 ) 4 -S-(CH 2 ) 5 -, ##-(CH 2 ) 4 -S-(CH 2 ) 6 -, ##-(CH 2 ) 5 -S-(CH 2 ) 1 -, ##-(CH 2 ) 5 -S-(CH 2 ) 2 -, ##-(CH 2 ) 5 -S-(CH 2 ) 3 -, ##-(CH 2 ) 5 -S-(CH 2 ) 4 -, ##-(CH 2 ) 5 -S-(CH 2 ) 5 -, ##-(CH 2 ) 6 -S-(CH 2 ) 1 -, ##-(CH 2 ) 6 -S-(CH 2 ) 2 -, ##-(CH 2 ) 6 -S-(CH 2 ) 3 -, ##-(CH 2 ) 6 -S-(CH 2 ) 4 -, ##-(CH 2 ) 7 -S-(CH 2 ) 1 -, ##-(CH 2 ) 7 -S-(CH 2 ) 2 -, ##-(CH 2 ) 7 -S-(CH 2 ) 3 -, ##-(CH 2 ) 8 -S-(CH 2 ) 1 -, ##-(CH 2 ) 8 -S-(CH 2 ) 2 -, ##-CH 2 -C(S)-CH 2 -, ##-CH 2 -C(S)-(CH 2 ) 2 -, ##-(CH 2 ) 1 -C(S)-(CH 2 ) 3 -, ##-(CH 2 ) 1 -C(S)-(CH 2 ) 4 -, ##-(CH 2 ) 1 -C(S)-(CH 2 ) 5 -, ##-(CH 2 ) 1 -C(S)-(CH 2 ) 6 -, ##-(CH 2 ) 1 -C(S)-(CH 2 ) 7 -, ##-(CH 2 ) 1 -C(S)-(CH 2 ) 8 -, ##-(CH 2 ) 1 -C(S)-(CH 2 ) 9 -, ##-(CH 2 ) 1 -C(S)-(CH 2 ) 10 -, ##-(CH 2 ) 2 -C(S)-(CH 2 ) 1 -, ##-(CH 2 ) 2 -C(S)-(CH 2 ) 2 -, ##-(CH 2 ) 2 -C(S)-(CH 2 ) 3 -, ##-(CH 2 ) 2 -C(S)-(CH 2 ) 4 -, ##-(CH 2 ) 2 -C(S)-(CH 2 ) 5 -, ##-(CH 2 ) 2 -C(S)-(CH 2 ) 6 -, ##-(CH 2 ) 2 -C(S)-(CH 2 ) 7 -, ##-(CH 2 ) 2 -C(S)-(CH 2 ) 8 -, ##-(CH 2 ) 2 -C(S)-(CH 2 ) 9 -, ##-(CH 2 ) 2 -C(S)-(CH 2 ) 10 -, ##-(CH 2 ) 2 -C(S)-(CH 2 ) 11 -, ##-(CH 2 ) 2 -C(S)-(CH 2 ) 12 -, ##-(CH 2 ) 3 -C(S)-(CH 2 ) 1 -, ##-(CH 2 ) 3 -C(S)-(CH 2 ) 2 -, ##-(CH 2 ) 3 -C(S)-(CH 2 ) 3 -, ##-(CH 2 ) 3 -C(S)-(CH 2 ) 4 -, ##-(CH 2 ) 3 -C(S)-(CH 2 ) 5 -, ##-(CH 2 ) 3 -C(S)-(CH 2 ) 6 -, ##-(CH 2 ) 3 -C(S)-(CH 2 ) 7 -, ##-(CH 2 ) 4 -C(S)-(CH 2 ) 1 -, ##-(CH 2 ) 4 -C(S)-(CH 2 ) 2 -, ##-(CH 2 ) 4 -C(S)-(CH 2 ) 3 -, ##-(CH 2 ) 4 -C(S)-(CH 2 ) 4 -, ##-(CH 2 ) 4 -C(S)-(CH 2 ) 5 -, ##-(CH 2 ) 4 -C(S)-(CH 2 ) 6 -, ##-(CH 2 ) 5 -C(S)-(CH 2 ) 1 -, ##-(CH 2 ) 5 -C(S)-(CH 2 ) 2 -, ##-(CH 2 ) 5 -C(S)-(CH 2 ) 3 -, ##-(CH 2 ) 5 -C(S)-(CH 2 ) 4 -, ##-(CH 2 ) 5 -C(S)-(CH 2 ) 5 -, ##-(CH 2 ) 6 -C(S)-(CH 2 ) 1 -, ##-(CH 2 ) 6 -C(S)-(CH 2 ) 2 -, ##-(CH 2 ) 6 -C(S)-(CH 2 ) 3 -, ##-(CH 2 ) 6 -C(S)-(CH 2 ) 4 -, ##-(CH 2 ) 7 -C(S)-(CH 2 ) 1 -, ##-(CH 2 ) 7 -C(S)-(CH 2 ) 2 -, ##-(CH 2 ) 7 -C(S)-(CH 2 ) 3 -, ##-(CH 2 ) 8 -C(S)-(CH 2 ) 1 -, ##-(CH 2 ) 8 -C(S)-(CH 2 ) 2 -, ##-CH 2 -C(O)O-CH 2 -, ##-CH 2 -C(O)O-(CH 2 ) 2 -, ##-(CH 2 ) 1 -C(O)O-(CH 2 ) 3 -, ##-(CH 2 ) 1 -C(O)O-(CH 2 ) 4 -, ##-(CH 2 ) 1 -C(O)O-(CH 2 ) 5 -, ##-(CH 2 ) 1 -C(O)O-(CH 2 ) 6 -, ##-(CH 2 ) 1 -C(O)O-(CH 2 ) 7 -, ##-(CH 2 ) 1 -C(O)O-(CH 2 ) 8 -, ##-(CH 2 ) 1 -C(O)O-(CH 2 ) 9 -, ##-(CH 2 ) 1 -C(O)O-(CH 2 ) 10 -, ##-(CH 2 ) 2 -C(O)O-(CH 2 ) 1 -, ##-(CH 2 ) 2 -C(O)O-(CH 2 ) 2 -, ##-(CH 2 ) 2 -C(O)O-(CH 2 ) 3 -, ##-(CH 2 ) 2 -C(O)O-(CH 2 ) 4 -, ##-(CH 2 ) 2 -C(O)O-(CH 2 ) 5 -, ##-(CH 2 ) 2 -C(O)O-(CH 2 ) 6 -, ##-(CH 2 ) 2 -C(O)O-(CH 2 ) 7 -, ##-(CH 2 ) 2 -C(O)O-(CH 2 ) 8 -, ##-(CH 2 ) 2 -C(O)O-(CH 2 ) 9 -, ##-(CH 2 ) 2 -C(O)O-(CH 2 ) 10 -, ##-(CH 2 ) 2 -C(O)O-(CH 2 ) 11 -, ##-(CH 2 ) 2 -C(O)O-(CH 2 ) 12 -, ##-(CH 2 ) 3 -C(O)O-(CH 2 ) 1 -, ##-(CH 2 ) 3 -C(O)O-(CH 2 ) 2 -, ##-(CH 2 ) 3 -C(O)O-(CH 2 ) 3 -, ##-(CH 2 ) 3 -C(O)O-(CH 2 ) 4 -, ##-(CH 2 ) 3 -C(O)O-(CH 2 ) 5 -, ##-(CH 2 ) 3 -C(O)O-(CH 2 ) 6 -, ##-(CH 2 ) 3 -C(O)O-(CH 2 ) 7 -, ##-(CH 2 ) 4 -C(O)O-(CH 2 ) 1 -, ##-(CH 2 ) 4 -C(O)O-(CH 2 ) 2 -, ##-(CH 2 ) 4 -C(O)O-(CH 2 ) 3 -, ##-(CH 2 ) 4 -C(O)O-(CH 2 ) 4 -, ##-(CH 2 ) 4 -C(O)O-(CH 2 ) 5 -, ##-(CH 2 ) 4 -C(O)O-(CH 2 ) 6 -, ##-(CH 2 ) 5 -C(O)O-(CH 2 ) 1 -, ##-(CH 2 ) 5 -C(O)O-(CH 2 ) 2 -, ##-(CH 2 ) 5 -C(O)O-(CH 2 ) 3 -, ##-(CH 2 ) 5 -C(O)O-(CH 2 ) 4 -, ##-(CH 2 ) 5 -C(O)O-(CH 2 ) 5 -, ##-(CH 2 ) 6 -C(O)O-(CH 2 ) 1 -, ##-(CH 2 ) 6 -C(O)O-(CH 2 ) 2 -, ##-(CH 2 ) 6 -C(O)O-(CH 2 ) 3 -, ##-(CH 2 ) 6 -C(O)O-(CH 2 ) 4 -, ##-(CH 2 ) 7 -C(O)O-(CH 2 ) 1 -, ##-(CH 2 ) 7 -C(O)O-(CH 2 ) 2 -, ##-(CH 2 ) 7 -C(O)O-(CH 2 ) 3 -, ##-(CH 2 ) 8 -C(O)O-(CH 2 ) 1 -, ##-(CH 2 ) 8 -C(O)O-(CH 2 ) 2 -, ##-CH 2 -OC(O)-CH 2 -, ##-CH 2 -OC(O)-(CH 2 ) 2 -, ##-(CH 2 ) 1 -OC(O)-(CH 2 ) 3 -, ##-(CH 2 ) 1 -OC(O)-(CH 2 ) 4 -, ##-(CH 2 ) 1 -OC(O)-(CH 2 ) 5 -, ##-(CH 2 ) 1 -OC(O)-(CH 2 ) 6 -, ##-(CH 2 ) 1 -OC(O)-(CH 2 ) 7 -, ##-(CH 2 ) 1 -OC(O)-(CH 2 ) 8 -, ##-(CH 2 ) 1 -OC(O)-(CH 2 ) 9 -, ##-(CH 2 ) 1 -OC(O)-(CH 2 ) 10 -, ##-(CH 2 ) 2 -OC(O)-(CH 2 ) 1 -, ##-(CH 2 ) 2 -OC(O)-(CH 2 ) 2 -, ##-(CH 2 ) 2 -OC(O)-(CH 2 ) 3 -, ##-(CH 2 ) 2 -OC(O)-(CH 2 ) 4 -, ##-(CH 2 ) 2 -OC(O)-(CH 2 ) 5 -, ##-(CH 2 ) 2 -OC(O)-(CH 2 ) 6 -, ##-(CH 2 ) 2 -OC(O)-(CH 2 ) 7 -, ##-(CH 2 ) 2 -OC(O)-(CH 2 ) 8 -, ##-(CH 2 ) 2 -OC(O)-(CH 2 ) 9 -, ##-(CH 2 ) 2 -OC(O)-(CH 2 ) 10 -, ##-(CH 2 ) 2 -OC(O)-(CH 2 ) 11 -, ##-(CH 2 ) 2 -OC(O)-(CH 2 ) 12 -, ##-(CH 2 ) 3 -OC(O)-(CH 2 ) 1 -, ##-(CH 2 ) 3 -OC(O)-(CH 2 ) 2 -, ##-(CH 2 ) 3 -OC(O)-(CH 2 ) 3 -, ##-(CH 2 ) 3 -OC(O)-(CH 2 ) 4 -, ##-(CH 2 ) 3 -OC(O)-(CH 2 ) 5 -, ##-(CH 2 ) 3 -OC(O)-(CH 2 ) 6 -, ##-(CH 2 ) 3 -OC(O)-(CH 2 ) 7 -, ##-(CH 2 ) 4 -OC(O)-(CH 2 ) 1 -, ##-(CH 2 ) 4 -OC(O)-(CH 2 ) 2 -, ##-(CH 2 ) 4 -OC(O)-(CH 2 ) 3 -, ##-(CH 2 ) 4 -OC(O)-(CH 2 ) 4 -, ##-(CH 2 ) 4 -OC(O)-(CH 2 ) 5 -, ##-(CH 2 ) 4 -OC(O)-(CH 2 ) 6 -, ##-(CH 2 ) 5 -OC(O)-(CH 2 ) 1 -, ##-(CH 2 ) 5 -OC(O)-(CH 2 ) 2 -, ##-(CH 2 ) 5 -OC(O)-(CH 2 ) 3 -, ##-(CH 2 ) 5 -OC(O)-(CH 2 ) 4 -, ##-(CH 2 ) 5 -OC(O)-(CH 2 ) 5 -, ##-(CH 2 ) 6 -OC(O)-(CH 2 ) 1 -, ##-(CH 2 ) 6 -OC(O)-(CH 2 ) 2 -, ##-(CH 2 ) 6 -OC(O)-(CH 2 ) 3 -, ##-(CH 2 ) 6 -OC(O)-(CH 2 ) 4 -, ##-(CH 2 ) 7 -OC(O)-(CH 2 ) 1 -, ##-(CH 2 ) 7 -OC(O)-(CH 2 ) 2 -, ##-(CH 2 ) 7 -OC(O)-(CH 2 ) 3 -, ##-(CH 2 ) 8 -OC(O)-(CH 2 ) 1 -, ##-(CH 2 ) 8 -OC(O)-(CH 2 ) 2 -, ##-(CH 2 ) 1 -N(R g10 )-(CH 2 ) 1 -, ##-(CH 2 ) 1 -N(R g10 )-(CH 2 ) 2 -, ##-(CH 2 ) 1 -N(R g10 )-(CH 2 ) 3 -, ##-(CH 2 ) 1 -N(R g10 )-(CH 2 ) 4 -, ##-(CH 2 ) 1 -N(R g10 )-(CH 2 ) 5 -, ##-(CH 2 ) 1 -N(R g10 )-(CH 2 ) 6 -, ##-(CH 2 ) 1 -N(R g10 )-(CH 2 ) 7 -, ##-(CH 2 ) 1 -N(R g10 )-(CH 2 ) 8 -, ##-(CH 2 ) 1 -N(R g10 )-(CH 2 ) 9 -, ##-(CH 2 ) 1 -N(R g10 )-(CH 2 ) 10 -, ##-(CH 2 ) 2 -N(R g10 )-(CH 2 ) 1 -, ##-(CH 2 ) 2 -N(R g10 )-(CH 2 ) 2 -, ##-(CH 2 ) 2 -N(R g10 )-(CH 2 ) 3 -, ##-(CH 2 ) 2 -N(R g10 )-(CH 2 ) 4 -, ##-(CH 2 ) 2 -N(R g10 )-(CH 2 ) 5 -, ##-(CH 2 ) 2 -N(R g10 )-(CH 2 ) 6 -, ##-(CH 2 ) 2 -N(R g10 )-(CH 2 ) 7 -, ##-(CH 2 ) 2 -N(R g10 )-(CH 2 ) 8 -, ##-(CH 2 ) 2 -N(R g10 )-(CH 2 ) 9 -, ##-(CH 2 ) 2 -N(R g10 )-(CH 2 ) 10 -, ##-(CH 2 ) 2 -N(R g10 )-(CH 2 ) 11 -, ##-(CH 2 ) 2 -N(R g10 )-(CH 2 ) 12 -, ##-(CH 2 ) 3 -N(R g10 )-(CH 2 ) 1 -, ##-(CH 2 ) 3 -N(R g10 )-(CH 2 ) 2 -, ##-(CH 2 ) 3 -N(R g10 )-(CH 2 ) 3 -, ##-(CH 2 ) 4 -N(R g10 )-(CH 2 ) 1 -, ##-(CH 2 ) 4 -N(R g10 )-(CH 2 ) 2 -, ##-(CH 2 ) 4 -N(R g10 )-(CH 2 ) 3 -, ##-(CH 2 ) 4 -N(R g10 )-(CH 2 ) 4 -, ##-(CH 2 ) 5 -N(R g10 )-(CH 2 ) 1 -, ##-(CH 2 ) 5 -N(R g10 )-(CH 2 ) 2 -, ##-(CH 2 ) 5 -N(R g10 )-(CH 2 ) 3 -, ##-(CH 2 ) 5 -N(R g10 )-(CH 2 ) 4 -, ##-(CH 2 ) 5 -N(R g10 )-(CH 2 ) 5 -, ##-(CH 2 ) 6 -N(R g10 )-(CH 2 ) 1 -, ##-(CH 2 ) 6 -N(R g10 )-(CH 2 ) 2 -, ##-(CH 2 ) 6 -N(R g10 )-(CH 2 ) 3 -, ##-(CH 2 ) 7 -N(R g10 )-(CH 2 ) 1 -, ##-(CH 2 ) 7 -N(R g10 )-(CH 2 ) 2 -, ##-(CH 2 ) 7 -N(R g10 )-(CH 2 ) 3 -, ##-(CH 2 ) 8 -N(R g10 )-(CH 2 ) 1 -, ##-(CH 2 ) 8 -N R g10 )-(CH 2 ) 2 -, ##-(CH 2 ) 8 -N(R g10 )-(CH 2 ) 3 -, ##-CH(CH 3 )-N(R g10 )-(CH 2 ) 1 -, ##-CH(CH 3 )-N(R g10 )-(CH 2 ) 2 -, ##-CH(CH 3 )-N(R g10 )-(CH 2 ) 3 -, ##-CH(CH 3 )-N(R g10 )-(CH 2 ) 4 -, ##-CH(CH 3 )-N(R g10 )-(CH 2 ) 5 -, ##-CH(CH 3 )-N(R g10 )-(CH 2 ) 6 -, ##-CH(CH 3 )-N(R g10 )-(CH 2 ) 7 -, ##-CH(CH 3 )-N(R g10 )-(CH 2 ) 8 -, ##-CH(CH 3 )-N(R g10 )-(CH 2 ) 9 -, ##-CH(CH 3 )-N(R g10 )-(CH 2 ) 10 -, ##-CH 2 C(O)NHCH 2 -, ##-(CH 2 ) 2 C(O)NH(CH 2 ) 2 -, ##-(CH 2 ) 2 C(O)NH(CH 2 ) 3 -, ##-(CH 2 ) 2 C(O)NH(CH 2 ) 4 -, ##-(CH 2 ) 2 C(O)NH(CH 2 ) 5 -, ##-(CH 2 ) 3 C(O)NH(CH 2 ) 3 -, ##-(CH 2 ) 3 C(O)NH(CH 2 ) 4 -, ##-(CH 2 ) 4 C(O)NH(CH 2 ) 4 -, ##-(CH 2 ) 5 C(O)NH(CH 2 ) 5 -, ##-(CH 2 ) 6 C(O)NH(CH 2 ) 7 -, ##-(CH 2 ) 6 C(O)NH(CH 2 ) 6 -, ##-(CH 2 ) 7 C(O)NH(CH 2 ) 7 -, ##-(CH 2 ) 8 C(O)NH(CH 2 ) 8 , ##-(CH 2 ) 9 C(O)NH(CH 2 ) 9 -, ##-(CH 2 ) 10 C(O)NH(CH 2 ) 10 -, ##-(CH 2 ) 2 C(O)NH(CH 2 ) 2 -O-(CH 2 ) 2 -, ##-CH 2 NHC(O)CH 2 -, ##-(CH 2 ) 2 NHC(O)(CH 2 ) 2 -, ##-(CH 2 ) 2 NHC(O)(CH 2 ) 3 -, ##-(CH 2 ) 2 NHC(O)(CH 2 ) 4 -, ##-(CH 2 ) 2 NHC(O)(CH 2 ) 5 -, ##-(CH 2 ) 3 NHC(O)(CH 2 ) 3 -, ##-(CH 2 ) 3 NHC(O)(CH 2 ) 4 -, ##-(CH 2 ) 4 NHC(O)(CH 2 ) 4 -, ##-(CH 2 ) 5 NHC(0)(CH 2 ) 5 -, ##-(CH 2 ) 6 NHC(O)(CH 2 ) 7 -, ##-(CH 2 ) 6 NHC(O)(CH 2 ) 6 -, ##-(CH 2 ) 7 NHC(O)(CH 2 ) 7 -, ##-(CH 2 ) 8 NHC(O)(CH 2 ) 8 , ##-(CH 2 ) 9 NHC(O)(CH 2 ) 9 -, ##-(CH 2 ) 10 NHC(O)(CH 2 ) 10 -, ##-(CH 2 ) 4 NHC(O)(CH 2 ) 8 -, ##-(CH 2 ) 2 NHC(O)(CH 2 ) 2 -O-(CH 2 ) 2 -, ##-(CH 2 ) 4 NHC(O)CH 2 -, ##-CH 2 -piperidinylene-CH 2 -, ##-CH 2 -piperidinylene-(CH 2 ) 2 -, ##-CH 2 -piperidinylene-(CH 2 ) 3 -, ##-CH 2 -piperidinylene-(CH 2 ) 4 -, ##-CH 2 -piperidinylene-(CH 2 ) 5 -, ##-CH 2 -piperidinylene-(CH 2 ) 6 -, ##-CH 2 -piperidinylene-(CH 2 ) 7 -, ##-CH 2 -piperidinylene-(CH 2 ) 8 -, ##-(CH 2 ) 2 -piperidinylene-(CH 2 ) 1 -, ##-(CH 2 ) 2 -piperidinylene-(CH 2 ) 2 -, ##-(CH 2 ) 2 -piperidinylene-(CH 2 ) 3 -, ##-(CH 2 ) 2 -piperidinylene-(CH 2 ) 4 -, ##-(CH 2 ) 2 -piperidinylene-(CH 2 ) 5 -, ##-(CH 2 ) 2 -piperidinylene-(CH 2 ) 6 -, ##-(CH 2 ) 2 -piperidinylene-(CH 2 ) 7 -, ##-(CH 2 ) 2 -piperidinylene-(CH 2 ) 8 -, ##-(CH 2 ) 3 -piperidinylene-CH 2 -, ##-(CH 2 ) 3 -piperidinylene-(CH 2 ) 2 -, ##-(CH 2 ) 3 -piperidinylene-(CH 2 ) 3 -, ##-(CH 2 ) 3 -piperidinylene-(CH 2 ) 4 -, ##-(CH 2 ) 3 -piperidinylene-(CH 2 ) 5 -, ##-(CH 2 ) 3 -piperidinylene-(CH 2 ) 6 -, ##-(CH 2 ) 3 -piperidinylene-(CH 2 ) 7 -, ##-(CH 2 ) 3 -piperidinylene-(CH 2 ) 8 -, ##-(CH 2 ) 4 -piperidinylene-CH 2 -, ##-(CH 2 ) 4 -piperidinylene-(CH 2 ) 2 -, ##-(CH 2 ) 4 -piperidinylene-(CH 2 ) 3 -, ##-(CH 2 ) 4 -piperidinylene-(CH 2 ) 4 -, ##-(CH 2 ) 4 -piperidinylene-(CH 2 ) 5 -, ##-(CH 2 ) 4 -piperidinylene-(CH 2 ) 6 -, ##-(CH 2 ) 4 -piperidinylene-(CH 2 ) 7 -, ##-(CH 2 ) 4 -piperidinylene-(CH 2 ) 8 -, ##-(CH 2 ) 5 -piperidinylene-(CH 2 ) 1 -, ##-(CH 2 ) 5 -piperidinylene-(CH 2 ) 2 -, ##-(CH 2 ) 5 -piperidinylene-(CH 2 ) 3 -, ##-(CH 2 ) 5 -piperidinylene-(CH 2 ) 4 -, ##-(CH 2 ) 5 -piperidinylene-(CH 2 ) 5 -, ##-(CH 2 ) 5 -piperidinylene-(CH 2 ) 6 -, ##-(CH 2 ) 5 -piperidinylene-(CH 2 ) 7 -, ##-(CH 2 ) 5 -piperidinylene-(CH 2 ) 8 -, ##-(CH 2 ) 6 -piperidinylene-(CH 2 ) 1 -, ##-(CH 2 ) 6 -pipendinylene-(CH 2 ) 2 -, ##-(CH 2 ) 6 -piperidinylene-(CH 2 ) 3 -, ##-(CH 2 ) 6 -piperidinylene-(CH 2 ) 4 -, ##-(CH 2 ) 6 -piperidinylene-(CH 2 ) 5 -, ##-(CH 2 ) 6 -piperidinylene-(CH 2 ) 6 -, ##-(CH 2 ) 6 -piperidinylene-(CH 2 ) 7 -, ##-(CH 2 ) 6 -piperidinylene-(CH 2 ) 8 -, ##-(CH 2 ) 7 -piperidinylene-(CH 2 ) 1 -, ##-(CH 2 ) 7 -piperidinylene-(CH 2 ) 2 -, ##-(CH 2 ) 7 -piperidinylene-(CH 2 ) 3 -, ##-(CH 2 ) 7 -piperidinylene-(CH 2 ) 4 -, ##-(CH 2 ) 7 -piperidinylene-(CH 2 ) 8 -, ##-(CH 2 ) 8 -piperidinylene-CH 2 -, ##-(CH 2 ) 8 -piperidinylene-(CH 2 ) 2 -, ##-(CH 2 ) 8 -piperidinylene-(CH 2 ) 3 -, ##-(CH 2 ) 8 -piperidinylene-(CH 2 ) 4 -, ##-(CH 2 ) 8 -piperidinylene-(CH 2 ) 5 -, ##-(CH 2 ) 8 -piperidinylene-(CH 2 ) 6 -, ##-(CH 2 ) 8 -piperidinylene-(CH 2 ) 7 -, ##-(CH 2 ) 8 -piperidinylene-(CH 2 ) 8 -, ##-CH 2 -piperazinylene-CH 2 -, ##-CH 2 -piperazinylene-(CH 2 ) 2 -, ##-CH 2 -piperazinylene-(CH 2 ) 3 -, ##-CH 2 -piperazinylene-(CH 2 ) 4 -, ##-CH 2 -piperazinylene-(CH 2 ) 5 -, ##-CH 2 -piperazinylene-(CH 2 ) 6 -, ##-CH 2 -piperazinylene-(CH 2 ) 7 -, ##-CH 2 -piperazinylene-(CH 2 ) 8 -, ##-(CH 2 ) 2 -piperazinylene-(CH 2 ) 1 -, ##-(CH 2 ) 2 -piperazinylene-(CH 2 ) 2 -, ##-(CH 2 ) 2 -piperazinylene-(CH 2 ) 3 -, ##-(CH 2 ) 2 -piperazinylene-(CH 2 ) 4 -, ##-(CH 2 ) 2 -piperazinylene-(CH 2 ) 5 -, ##-(CH 2 ) 2 -piperazinylene-(CH 2 ) 6 -, ##-(CH 2 ) 2 -piperazinylene-(CH 2 ) 7 -, ##-(CH 2 ) 2 -piperazinylene-(CH 2 ) 8 -, ##-(CH 2 ) 3 -piperazinylene-CH 2 -, ##-(CH 2 ) 3 -piperazinylene-(CH 2 ) 2 -, ##-(CH 2 ) 3 -piperazinylene-(CH 2 ) 3 -, ##-(CH 2 ) 3 -piperazinylene-(CH 2 ) 4 -, ##-(CH 2 ) 3 -piperazinylene-(CH 2 ) 5 -, ##-(CH 2 ) 3 -piperazinylene-(CH 2 ) 6 -, ##-(CH 2 ) 3 -piperazinylene-(CH 2 ) 7 -, ##-(CH 2 ) 3 -piperazinylene-(CH 2 ) 8 -, ##-(CH 2 ) 4 -piperazinylene-CH 2 -, ##-(CH 2 ) 4 -piperazinylene-(CH 2 ) 2 -, ##-(CH 2 ) 4 -piperazinylene-(CH 2 ) 3 -, ##-(CH 2 ) 4 -piperazinylene-(CH 2 ) 4 -, ##-(CH 2 ) 4 -piperazinylene-(CH 2 ) 5 -, ##-(CH 2 ) 4 -piperazinylene-(CH 2 ) 6 -, ##-(CH 2 ) 4 -piperazinylene-(CH 2 ) 7 -, ##-(CH 2 ) 4 -piperazinylene-(CH 2 ) 8 -, ##-(CH 2 ) 5 -piperazinylene-(CH 2 ) 1 -, ##-(CH 2 ) 5 -piperazinylene-(CH 2 ) 2 -, ##-(CH 2 ) 5 -piperazinylene-(CH 2 ) 3 -, ##-(CH 2 ) 5 -piperazinylene-(CH 2 ) 4 -, ##-(CH 2 ) 5 -piperazinylene-(CH 2 ) 5 -, ##-(CH 2 ) 5 -piperazinylene-(CH 2 ) 6 -, ##-(CH 2 ) 5 -piperazinylene-(CH 2 ) 7 -, ##-(CH 2 ) 5 -piperazinylene-(CH 2 ) 8 -, ##-(CH 2 ) 6 -piperazinylene-(CH 2 ) 1 -, ##-(CH 2 ) 6 -piperazinylene-(CH 2 ) 2 -, ##-(CH 2 ) 6 -piperazinylene-(CH 2 ) 3 -, ##-(CH 2 ) 6 -piperazinylene-(CH 2 ) 4 -, ##-(CH 2 ) 6 -piperazinylene-(CH 2 ) 5 -, ##-(CH 2 ) 6 -piperazinylene-(CH 2 ) 6 -, ##-(CH 2 ) 6 -piperazinylene-(CH 2 ) 7 -, ##-(CH 2 ) 6 -piperazinylene-(CH 2 ) 8 -, ##-(CH 2 ) 7 -piperazinylene-(CH 2 ) 1 -, ##-(CH 2 ) 7 -piperazinylene-(CH 2 ) 2 -, ##-(CH 2 ) 7 -piperazinylene-(CH 2 ) 3 -, ##-(CH 2 ) 7 -piperazinylene-(CH 2 ) 4 -, ##-(CH 2 ) 7 -piperazinylene-(CH 2 ) 8 -, ##-(CH 2 ) 8 -piperazinylene-CH 2 -, ##-(CH 2 ) 8 -piperazinylene-(CH 2 ) 2 -, ##-(CH 2 ) 8 -piperazinylene-(CH 2 ) 3 -, ##-(CH 2 ) 8 -piperazinylene-(CH 2 ) 4 -, ##-(CH 2 ) 8 -piperazinylene-(CH 2 ) 5 -, ##-(CH 2 ) 8 -piperazinylene-(CH 2 ) 6 -, ##-(CH 2 ) 8 -piperazinylene-(CH 2 ) 7 -, ##-(CH 2 ) 8 -piperazinylene-(CH 2 ) 8 -, ##-CH 2 -propylene-CH 2 -, ##-CH 2 -propylene-(CH 2 ) 2 -, ##-CH 2 -propylene-(CH 2 ) 3 -, ##-CH 2 -propylene-(CH 2 ) 4 -, ##-CH 2 -propylene-(CH 2 ) 5 -, ##-CH 2 -propylene-(CH 2 ) 6 -, ##-CH 2 -propylene-(CH 2 ) 7 -, ##-CH 2 -propylene-(CH 2 ) 8 -, ##-(CH 2 ) 2 -propylene-(CH 2 ) 1 -, ##-(CH 2 ) 2 -propylene-(CH 2 ) 2 -, ##-(CH 2 ) 2 -propylene-(CH 2 ) 3 -, ##-(CH 2 ) 2 -propylene-(CH 2 ) 4 -, ##-(CH 2 ) 2 -propylene-(CH 2 ) 5 -, ##-(CH 2 ) 2 -propylene-(CH 2 ) 6 -, ##-(CH 2 ) 2 -propylene-(CH 2 ) 7 -, ##-(CH 2 ) 2 -propylene-(CH 2 ) 8 -, ##-(CH 2 ) 3 -propylene-CH 2 -, ##-(CH 2 ) 3 -propylene-(CH 2 ) 2 -, ##-(CH 2 ) 3 -propylene-(CH 2 ) 3 -, ##-(CH 2 ) 3 -propylene-(CH 2 ) 4 -, ##-(CH 2 ) 3 -propylene-(CH 2 ) 5 -, ##-(CH 2 ) 3 -propylene-(CH 2 ) 6 -, ##-(CH 2 ) 3 -propylene-(CH 2 ) 7 -, ##-(CH 2 ) 3 -propylene-(CH 2 ) 8 -, ##-(CH 2 ) 4 -propylene-CH 2 -, ##-(CH 2 ) 4 -propylene-(CH 2 ) 2 -, ##-(CH 2 ) 4 -propylene-(CH 2 ) 3 -, ##-(CH 2 ) 4 -propylene-(CH 2 ) 4 -, ##-(CH 2 ) 4 -propylene-(CH 2 ) 5 -, ##-(CH 2 ) 4 -propylene-(CH 2 ) 6 -, ##-(CH 2 ) 4 -propylene-(CH 2 ) 7 -, ##-(CH 2 ) 4 -propylene-(CH 2 ) 8 -, ##-(CH 2 ) 5 -propylene-(CH 2 ) 1 -, ##-(CH 2 ) 5 -propylene-(CH 2 ) 2 -, ##-(CH 2 ) 5 -propylene-(CH 2 ) 3 -, ##-(CH 2 ) 5 -propylene-(CH 2 ) 4 -, ##-(CH 2 ) 5 -propylene-(CH 2 ) 5 -, ##-(CH 2 ) 5 -propylene-(CH 2 ) 6 -, ##-(CH 2 ) 5 -propylene-(CH 2 ) 7 -, ##-(CH 2 ) 5 -propylene-(CH 2 ) 8 -, ##-(CH 2 ) 6 -propylene-(CH 2 ) 1 -, ##-(CH 2 ) 6 -propylene-(CH 2 ) 2 -, ##-(CH 2 ) 6 -propylene-(CH 2 ) 3 -, ##-(CH 2 ) 6 -propylene-(CH 2 ) 4 -, ##-(CH 2 ) 6 -propylene-(CH 2 ) 5 -, ##-(CH 2 ) 6 -propylene-(CH 2 ) 6 -, ##-(CH 2 ) 6 -propylene-(CH 2 ) 7 -, ##-(CH 2 ) 6 -propylene-(CH 2 ) 8 -, ##-(CH 2 ) 7 -propylene-(CH 2 ) 1 -, ##-(CH 2 ) 7 -propylene-(CH 2 ) 2 -, ##-(CH 2 ) 7 -propylene-(CH 2 ) 3 -, ##-(CH 2 ) 7 -propylene-(CH 2 ) 4 -, ##-(CH 2 ) 7 -propylene-(CH 2 ) 8 -, ##-(CH 2 ) 8 -propylene-CH 2 -, ##-(CH 2 ) 8 -propylene-(CH 2 ) 2 -, ##-(CH 2 ) 8 -propylene-(CH 2 ) 3 -, ##-(CH 2 ) 8 -propylene-(CH 2 ) 4 -, ##-(CH 2 ) 8 -propylene-(CH 2 ) 5 -, ##-(CH 2 ) 8 -propylene-(CH 2 ) 6 -, ##-(CH 2 ) 8 -propylene-(CH 2 ) 7 -, ##-(CH 2 ) 8 -propylene-(CH 2 ) 8 -, ##-CH 2 -diazacycloheptanylene-CH 2 -, ##-CH 2 -diazacycloheptanylene-(CH 2 ) 2 -, ##-CH 2 -diazacycloheptanylene-(CH 2 ) 3 -, ##-CH 2 -diazacycloheptanylene-(CH 2 ) 4 -, ##-CH 2 -diazacycloheptanylene-(CH 2 ) 5 -, ##-CH 2 -diazacycloheptanylene-(CH 2 ) 6 -, ##-CH 2 -diazacycloheptanylene-(CH 2 ) 7 -, ##-CH 2 -diazacycloheptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 2 -diazacycloheptanylene-(CH 2 ) 1 -, ##-(CH 2 ) 2 -diazacycloheptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 2 -diazacycloheptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 2 -diazacycloheptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 2 -diazacycloheptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 2 -diazacycloheptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 2 -diazacycloheptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 2 -diazacycloheptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 3 -diazacycloheptanylene-CH 2 -, ##-(CH 2 ) 3 -diazacycloheptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 3 -diazacycloheptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 3 -diazacycloheptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 3 -diazacycloheptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 3 -diazacycloheptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 3 -diazacycloheptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 3 -diazacycloheptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 4 -diazacycloheptanylene-CH 2 -, ##-(CH 2 ) 4 -diazacycloheptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 4 -diazacycloheptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 4 -diazacycloheptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 4 -diazacycloheptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 4 -diazacycloheptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 4 -diazacycloheptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 4 -diazacycloheptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 5 -diazacycloheptanylene-(CH 2 ) 1 -, ##-(CH 2 ) 5 -diazacycloheptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 5 -diazacycloheptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 5 -diazacycloheptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 5 -diazacycloheptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 5 -diazacycloheptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 5 -diazacycloheptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 5 -diazacycloheptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 6 -diazacycloheptanylene-(CH 2 ) 1 -, ##-(CH 2 ) 6 -diazacycloheptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 6 -diazacycloheptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 6 -diazacycloheptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 6 -diazacycloheptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 6 -diazacycloheptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 6 -diazacycloheptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 6 -diazacycloheptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 7 -diazacycloheptanylene-(CH 2 ) 1 -, ##-(CH 2 ) 7 -diazacycloheptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 7 -diazacycloheptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 7 -diazacycloheptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 7 -diazacycloheptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 8 -diazacycloheptanylene-CH 2 -, ##-(CH 2 ) 8 -diazacycloheptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 8 -diazacycloheptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 8 -diazacycloheptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 8 -diazacycloheptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 8 -diazacycloheptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 8 -diazacycloheptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 8 -diazacycloheptanylene-(CH 2 ) 8 -, ##-CH 2 -diazabicyclo[2.2.1]heptanylene-CH 2 -, ##-CH 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 2 -, ##-CH 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 3 -, ##-CH 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 4 -, ##-CH 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 5 -, ##-CH 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 6 -, ##-CH 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 7 -, ##-CH 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 1 -, ##-(CH 2 ) 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 3 -diazabicyclo[2.2.1]heptanylene-CH 2 -, ##-(CH 2 ) 3 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 3 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 3 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 3 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 3 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 3 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 3 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 4 -diazabicyclo[2.2.1]heptanylene-CH 2 -, ##-(CH 2 ) 4 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 4 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 4 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 4 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 4 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 4 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 4 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 5 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 1 -, ##-(CH 2 ) 5 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 5 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 5 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 5 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 5 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 5 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 5 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 6 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 1 -, ##-(CH 2 ) 6 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 6 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 6 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 6 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 6 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 6 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 6 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 7 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 1 -, ##-(CH 2 ) 7 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 7 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 7 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 7 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 8 -diazabicyclo[2.2.1]heptanylene-CH 2 -, ##-(CH 2 ) 8 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 8 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 8 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 8 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 8 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 8 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 8 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 8 -, ##-CH 2 -diazabicyclo[3.1.1]heptanylene-CH 2 -, ##-CH 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 2 -, ##-CH 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 3 -, ##-CH 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 4 -, ##-CH 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 5 -, ##-CH 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 6 -, ##-CH 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 7 -, ##-CH 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 1 -, ##-(CH 2 ) 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 3 -diazabicyclo[3.1.1]heptanylene-CH 2 -, ##-(CH 2 ) 3 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 3 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 3 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 3 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 3 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 3 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 3 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 4 -diazabicyclo[3.1.1]heptanylene-CH 2 -, ##-(CH 2 ) 4 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 4 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 4 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 4 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 4 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 4 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 4 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 5 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 1 -, ##-(CH 2 ) 5 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 5 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 5 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 5 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 5 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 5 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 5 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 6 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 1 -, ##-(CH 2 ) 6 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 6 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 6 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 6 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 6 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 6 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 6 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 7 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 1 -, ##-(CH 2 ) 7 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 7 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 7 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 7 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 8 -diazabicyclo[3.1.1]heptanylene-CH 2 -, ##-(CH 2 ) 8 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 8 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 8 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 8 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 8 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 8 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 8 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 8 -, ##-CH 2 -diazabicyclo[3.2.1]octylene-CH 2 -, ##-CH 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 2 -, ##-CH 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 3 -, ##-CH 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 4 -, ##-CH 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 5 -, ##-CH 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 6 -, ##-CH 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 7 -, ##-CH 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 8 -, ##-(CH 2 ) 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 1 -, ##-(CH 2 ) 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 2 -, ##-(CH 2 ) 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 3 -, ##-(CH 2 ) 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 4 -, ##-(CH 2 ) 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 5 -, ##-(CH 2 ) 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 6 -, ##-(CH 2 ) 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 7 -, ##-(CH 2 ) 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 8 -, ##-(CH 2 ) 3 -diazabicyclo[3.2.1]octylene-CH 2 -, ##-(CH 2 ) 3 -diazabicyclo[3.2.1]octylene-(CH 2 ) 2 -, ##-(CH 2 ) 3 -diazabicyclo[3.2. 1]octylene-(CH 2 ) 3 -, ##-(CH 2 ) 3 -diazabicyclo[3.2.1]octylene-(CH 2 ) 4 -, ##-(CH 2 ) 3 -diazabicyclo[3.2. 1]octylene-(CH 2 ) 5 -, ##-(CH 2 ) 3 -diazabicyclo[3.2.1]octylene-(CH 2 ) 6 -, ##-(CH 2 ) 3 -diazabicyclo[3.2.1]octylene-(CH 2 ) 7 -, ##-(CH 2 ) 3 -diazabicyclo[3.2.1]octylene-(CH 2 ) 8 -, ##-(CH 2 ) 4 -diazabicyclo[3.2.1]octylene-CH 2 -, ##-(CH 2 ) 4 -diazabicyclo[3.2.1]octylene-(CH 2 ) 2 -, ##-(CH 2 ) 4 -diazabicyclo[3.2.1]octylene-(CH 2 ) 3 -, ##-(CH 2 ) 4 -diazabicyclo[3.2.1]octylene-(CH 2 ) 4 -, ##-(CH 2 ) 4 -diazabicyclo[3.2.1]octylene-(CH 2 ) 5 -, ##-(CH 2 ) 4 -diazabicyclo[3.2.1]octylene-(CH 2 ) 6 -, ##-(CH 2 ) 4 -diazabicyclo[3.2.1]octylene-(CH 2 ) 7 -, ##-(CH 2 ) 4 -diazabicyclo[3.2.1]octylene-(CH 2 ) 8 -, ##-(CH 2 ) 5 -diazabicyclo[3.2. 1]octylene-(CH 2 ) 1 -, ##-(CH 2 ) 5 -diazabicyclo[3.2.1]octylene-(CH 2 ) 2 -, ##-(CH 2 ) 5 -diazabicyclo[3.2. 1]octylene-(CH 2 ) 3 -, ##-(CH 2 ) 5 -diazabicyclo[3.2.1]octylene-(CH 2 ) 4 -, ##-(CH 2 ) 5 -diazabicyclo[3.2. 1]octylene-(CH 2 ) 5 -, ##-(CH 2 ) 5 -diazabicyclo[3.2.1]octylene-(CH 2 ) 6 -, ##-(CH 2 ) 5 -diazabicyclo[3.2.1]octylene-(CH 2 ) 7 -, ##-(CH 2 ) 5 -diazabicyclo[3.2.1]octylene-(CH 2 ) 8 -, ##-(CH 2 ) 6 -diazabicyclo[3 .2.1]octylene-(CH 2 ) 1 -, ##-(CH 2 ) 6 -diazabicyclo[3.2.1]octylene-(CH 2 ) 2 -, ##-(CH 2 ) 6 -diazabicyclo[3.2.1]octylene-(CH 2 ) 3 -, ##-(CH 2 ) 6 -diazabicyclo[3.2.1]octylene-(CH 2 ) 4 -, ##-(CH 2 ) 6 -diazabicyclo[3.2.1]octylene-(CH 2 ) 5 -, ##-(CH 2 ) 6 -diazabicyclo[3.2.1]octylene-(CH 2 ) 6 -, ##-(CH 2 ) 6 -diazabicyclo[3.2.1]octylene-(CH 2 ) 7 -, ##-(CH 2 ) 6 -diazabicyclo[3.2.1]octylene-(CH 2 ) 8 -, ##-(CH 2 ) 7 -diazabicyclo[3.2. 1]octylene-(CH 2 ) 1 -, ##-(CH 2 ) 7 -diazabicyclo[3.2.1]octylene-(CH 2 ) 2 -, ##-(CH 2 ) 7 -diazabicyclo[3.2.1]octylene-(CH 2 ) 3 -, ##-(CH 2 ) 7 -diazabicyclo[3.2.1]octylene-(CH 2 ) 4 -, ##-(CH 2 ) 7 -diazabicyclo[3.2.1]octylene-(CH 2 ) 8 -, ##-(CH 2 ) 8 -diazabicyclo[3.2.1]octylene-CH 2 -, ##-(CH 2 ) 8 -diazabicyclo[3.2.1]octylene-(CH 2 ) 2 -, ##-(CH 2 ) 8 -diazabicyclo[3.2.1]octylene-(CH 2 ) 3 -, ##-(CH 2 ) 8 -diazabicyclo[3.2.1]octylene-(CH 2 ) 4 -, ##-(CH 2 ) s -diazabicyclo[3.2.1]octylene-(CH 2 ) 5 -, ##-(CH 2 ) 8 -diazabicyclo[3.2.1]octylene-(CH 2 ) 6 -, ##-(CH 2 ) 8 -diazabicyclo[3.2.1]octylene-(CH 2 ) 7 -, ##-(CH 2 ) 8 -diazabicyclo[3.2.1]octylene-(CH 2 ) 8 -, ##-CH 2 -diazabicyclo[2.2.2]octylene-CH 2 -, ##-CH 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 2 -, ##-CH 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 3 -, ##-CH 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 4 -, ##-CH 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 5 -, ##-CH 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 6 -, ##-CH 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 7 -, ##-CH 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 8 -, ##-(CH 2 ) 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 1 -, ##-(CH 2 ) 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 2 -, ##-(CH 2 ) 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 3 -, ##-(CH 2 ) 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 4 -, ##-(CH 2 ) 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 5 -, ##-(CH 2 ) 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 6 -, ##-(CH 2 ) 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 7 -, ##-(CH 2 ) 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 8 -, ##-(CH 2 ) 3 -diazabicyclo[2.2.2]octylene-CH 2 -, ##-(CH 2 ) 3 -diazabicyclo[2.2.2]octylene-(CH 2 ) 2 -, ##-(CH 2 ) 3 -diazabicyclo[2.2.2]octylene-(CH 2 ) 3 -, ##-(CH 2 ) 3 -diazabicyclo[2.2.2]octylene-(CH 2 ) 4 -, ##-(CH 2 ) 3 -diazabicyclo[2.2.2]octylene-(CH 2 ) 5 -, ##-(CH 2 ) 3 -diazabicyclo[2.2.2]octylene-(CH 2 ) 6 -, ##-(CH 2 ) 3 -diazabicyclo[2.2.2]octylene-(CH 2 ) 7 -, ##-(CH 2 ) 3 -diazabicyclo[2.2.2]octylene-(CH 2 ) 8 -, ##-(CH 2 ) 4 -diazabicyclo[2.2.2]octylene-CH 2 -, ##-(CH 2 ) 4 -diazabicyclo[2.2.2]octylene-(CH 2 ) 2 -, ##-(CH 2 ) 4 -diazabicyclo[2.2.2]octylene-(CH 2 ) 3 -, ##-(CH 2 ) 4 -diazabicyclo[2.2.2]octylene-(CH 2 ) 4 -, ##-(CH 2 ) 4 -diazabicyclo[2.2.2]octylene-(CH 2 ) 5 -, ##-(CH 2 ) 4 -diazabicyclo[2.2.2]octylene-(CH 2 ) 6 -, ##-(CH 2 ) 4 -diazabicyclo[2.2.2]octylene-(CH 2 ) 7 -, ##-(CH 2 ) 4 -diazabicyclo[2.2.2]octylene-(CH 2 ) 8 -, ##-(CH 2 ) 5 -diazabicyclo[2.2.2]octylene-(CH 2 ) 1 -, ##-(CH 2 ) 5 -diazabicyclo[2.2.2]octylene-(CH 2 ) 2 -, ##-(CH 2 ) 5 -diazabicyclo[2.2.2]octylene-(CH 2 ) 3 -, ##-(CH 2 ) 5 -diazabicyclo[2.2.2]octylene-(CH 2 ) 4 -, ##-(CH 2 ) 5 -diazabicyclo[2.2.2]octylene-(CH 2 ) 5 -, ##-(CH 2 ) 5 -diazabicyclo[2.2.2]octylene-(CH 2 ) 6 -, ##-(CH 2 ) 5 -diazabicyclo[2.2.2]octylene-(CH 2 ) 7 -, ##-(CH 2 ) 5 -diazabicyclo[2.2.2]octylene-(CH 2 ) 8 -, ##-(CH 2 ) 6 -diazabicyclo[2.2.2]octylene-(CH 2 ) 1 -, ##-(CH 2 ) 6 -diazabicyclo[2.2.2]octylene-(CH 2 ) 2 -, ##-(CH 2 ) 6 -diazabicyclo[2.2.2]octylene-(CH 2 ) 3 -, ##-(CH 2 ) 6 -diazabicyclo[2.2.2]octylene-(CH 2 ) 4 -, ##-(CH 2 ) 6 -diazabicyclo[2.2.2]octylene-(CH 2 ) 5 -, ##-(CH 2 ) 6 -diazabicyclo[2.2.2]octylene-(CH 2 ) 6 -, ##-(CH 2 ) 6 -diazabicyclo[2.2.2]octylene-(CH 2 ) 7 -, ##-(CH 2 ) 6 -diazabicyclo[2.2.2]octylene-(CH 2 ) 8 -, ##-(CH 2 ) 7 -diazabicyclo[2.2.2]octylene-(CH 2 ) i -, ##-(CH 2 ) 7 -diazabicyclo[2.2.2]octylene-(CH 2 ) 2 -, ##-(CH 2 ) 7 -diazabicyclo[2.2.2]octylene-(CH 2 ) 3 -, ##-(CH 2 ) 7 -diazabicyclo[2.2.2]octylene-(CH 2 ) 4 -, ##-(CH 2 ) 7 -diazabicyclo[2.2.2]octylene-(CH 2 ) 5 -, ##-(CH 2 ) 8 -diazabicyclo[2.2.2]octylene-CH 2 -, ##-(CH 2 ) 8 -diazabicyclo[2.2.2]octylene-(CH 2 ) 2 -, ##-(CH 2 ) 8 -diazabicyclo[2.2.2]octylene-(CH 2 ) 3 -, ##-(CH 2 ) 8 -diazabicyclo[2.2.2]octylene-(CH 2 ) 4 -, ##-(CH 2 ) 8 -diazabicyclo[2.2.2]octylene-(CH 2 ) 5 -, ##-(CH 2 ) 8 -diazabicyclo[2.2.2]octylene-(CH 2 ) 6 -, ##-(CH 2 ) 8 -diazabicyclo[2.2.2]octylene-(CH 2 ) 7 -, or ##-(CH 2 ) 8 -diazabicyclo[2.2.2]octylene-(CH 2 ) 8 -, wherein the propylene, the piperidinylene, the piperazinylene, the diazacycloheptanylene, the diazabicyclo[2.2.1]heptanylene, the diazabicyclo[3.1.1]heptanylene, the diazabicyclo[3.2.1]octylene, the diazabicyclo[2.2.2]octylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C 1-4 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH- or any combination thereof; each R g10 independently represents H or C 1-3 alkyl; and symbol ## indicates the point of attachment to X 1 .

[0032] In some embodiments of the compound of Formula (I-1), L 1 represents the following group: wherein symbol ## indicates the point of attachment to X 1 .

[0033] In some embodiments of the compound of Formula (I-1), L 1 represents the structure of the following formula: ##-C 1-30 alkylene-, wherein a hydrogen atom of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) CH 2 groups of the C 1-30 alkylene is optionally replaced with a substituent selected from the group consisting of: D, optionally deuterated C 1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, C 1-6 alkoxy or any combination thereof, and symbol ## indicates the point of attachment to X 1 . In embodiments of the present disclosure, the number of substituents is not theoretically limited in any way or automatically limited by the size of the building units.

[0034] In some embodiments of the compound of Formula (I-1), L 1 represents the following group: ##-CH 2 -, ##-(CH 2 ) 2 -, ##-(CH 2 ) 3 -, ##-(CH 2 ) 4 -, ##-(CH 2 ) 5 -, ##-(CH 2 ) 2 -CF 2 -(CH 2 ) 2 -, ##-(CH 2 ) 6 -, ##-(CH 2 ) 7 -, ##-(CH 2 ) 8 -, ##-(CH 2 ) 9 -, ##-(CH 2 ) 10 -, ##-(CH 2 ) 11 -, ##-(CH 2 ) 12 -, ##-(CH 2 ) 13 -, ##-(CH 2 ) 14 -, ##-(CH 2 ) 15 -, ##-(CH 2 ) 16 -, ##-(CH 2 ) 17 -, ##-(CH 2 ) 18 -, ##-(CH 2 ) 19 -, ##-(CH 2 ) 20 -, ##-(CH 2 ) 21 -, ##-(CH 2 ) 22 -, ##-(CH 2 ) 25 -, or ##-(CH 2 ) 30 -; wherein a hydrogen atom of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) CH 2 of the group is optionally replaced with a substituent selected from the group consisting of: D, optionally deuterated C 1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, C 1-6 alkoxy or any combination thereof, and symbol ## indicates the point of attachment to X 1 . In embodiments of the present disclosure, the number of substituents is not theoretically limited in any way or automatically limited by the size of the building units.

[0035] In some embodiments of the compound of Formula (I-1), R b represents C 1-60 alkyl (e.g., C 1 -C 30 alkyl, C 1 -C 29 alkyl, C 1 -C 28 alkyl, C 1 -C 27 alkyl, C 1 -C 26 alkyl, C 1 -C 25 alkyl, C 1 -C 24 alkyl, C 1 -C 23 alkyl, C 1 -C 22 alkyl, C 1 -C 21 alkyl, C 1 -C 2O alkyl, C 1 -C 19 alkyl, C 1 -C 18 alkyl, C 1 -C 17 alkyl, C 1 -C 16 alkyl, C 1 -C 15 alkyl, C 1 -C 14 alkyl, C 1 -C 13 alkyl, C 1 -C 12 alkyl, C 1 -C 11 alkyl, C 1 -C 10 alkyl, C 1 -C 9 alkyl, C 1 -C 8 alkyl, C 1 -C 7 alkyl, C 1 -C 6 alkyl, C 1 -C 5 alkyl, C 1 -C 4 alkyl, C 1 -C 3 alkyl, or C 1 -C 2 alkyl) optionally substituted with D or halogen.

[0036] In some embodiments of the compound of Formula (I-1), R b represents the following group: CH 3 , CF 3 , CD 3 , CH 2 CH 3 , -(CH 2 ) 2 -CH 3 , -(CH 2 ) 3 -CH 3 , -(CH 2 ) 4 -CH 3 , -(CH 2 ) 5 -CH 3 , -(CH 2 ) 6 -CH 3 , - (CH 2 ) 7 -CH 3 , -(CH 2 ) 8 -CH 3 , -(CH 2 ) 9 -CH 3 , -(CH 2 ) 10 -CH 3 , -(CH 2 ) 11 -CH 3 , -(CH 2 ) 12 -CH 3 , -(CH 2 ) 13 -CH 3 , - (CH 2 ) 14 -CH 3 , -(CH 2 ) 15 -CH 3 , -(CH 2 ) 16 -CH 3 , -(CH 2 ) 17 -CH 3 , -(CH 2 ) 18 -CH 3 , -(CH 2 ) 19 -CH 3 , -(CH 2 ) 20 -CH 3 , -(CH 2 ) 21 -CH 3 , -(CH 2 ) 22 -CH 3 , -(CH 2 ) 23 -CH 3 , -(CH 2 ) 24 -CH 3 , -(CH 2 ) 25 -CH 3 , -(CH 2 ) 26 -CH 3 , -(CH 2 ) 27 -CH 3 , -(CH 2 ) 28 -CH 3 , or -(CH 2 ) 29 -CH 3 .

[0037] In some embodiments of the compound of Formula (I-1), R b represents the following formula:         R b1 -X 4 -L 2 - , wherein L 2 represents: linear or branched C 2-60 alkylene (e.g., C 2 -C 40 alkylene, C 2 -C 30 alkylene, C 2 -C 29 alkylene, C 2 -C 28 alkylene, C 2 -C 27 alkylene, C 2 -C 26 alkylene, C 2 -C 25 alkylene, C 2 -C 24 alkylene, C 2 -C 23 alkylene, C 2 -C 22 alkylene, C 2 -C 21 alkylene, C 2 -C 20 alkylene, C 2 -C 19 alkylene, C 2 -C 18 alkylene, C 2 -C 17 alkylene, C 2 -C 16 alkylene, C 2 -C 15 alkylene, C 2 -C 14 alkylene, C 2 -C 13 alkylene, C 2 -C 12 alkylene, C 2 -C 11 alkylene, C 2 -C 10 alkylene, C 2 -C 9 alkylene, C 2 -C 8 alkylene, C 2 -C 7 alkylene, C 2 -C 6 alkylene, C 2 -C 5 alkylene, C 2 -C 4 alkylene, C 2 -C 3 alkylene, or ethylene) optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, C 1-4 alkyl, halogen, C 3-6 cycloalkyl or any combination thereof, or optionally substituted linear or branched C 2-60 alkylene (e.g., C 2 -C 40 alkylene, C 2 -C 30 alkylene, C 2 -C 29 alkylene, C 2 -C 28 alkylene, C 2 -C 27 alkylene, C 2 -C 26 alkylene, C 2 -C 25 alkylene, C 2 -C 24 alkylene, C 2 -C 23 alkylene, C 2 -C 22 alkylene, C 2 -C 21 alkylene, C 2 -C 20 alkylene, C 2 -C 19 alkylene, C 2 -C 18 alkylene, C 2 -C 17 alkylene, C 2 -C 16 alkylene, C 2 -C 15 alkylene, C 2 -C 14 alkylene, C 2 -C 13 alkylene, C 2 -C 12 alkylene, C 2 -C 11 alkylene, C 2 -C 10 alkylene, C 2 -C 9 alkylene, C 2 -C 8 alkylene, C 2 -C 7 alkylene, C 2 -C 6 alkylene, C 2 -C 5 alkylene, C 2 -C 4 alkylene, C 2 -C 3 alkylene, or ethylene) with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R 12 and / or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R 13 and / or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R 12 and R 13 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs (e.g., 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1 pair) of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R 12 , R 13 , or a combination of R 12 and R 13 ; wherein each R 12 is independently selected from the group consisting of O, S, N(R 14 ), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O) 2 , S(O) 2 O, OS(O) 2 , S(O) 2 NH or NHS(O) 2 , wherein R 14 independently represents H or C 1-3 alkyl, and in case that two or more groups R 12 are inserted into the backbone carbon chain of the linear or branched C 2-60 alkylene group, the two or more groups R 12 are not directly connected to each other; and wherein each R 13 is independently selected from the group consisting of C 3-15 cycloalkylene, 4- to 15-membered heterocyclylene, C 6-10 arylene, 5- to 15-membered heteroarylene, C 2-6 alkenylene, C 2-6 alkynylene or any combination thereof, wherein the C 3-15 cycloalkylene, the 4- to 15-membered heterocyclylene, C 6-10 arylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C 1-4 alkyl (e.g., optionally deuterated C 1-3 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C 3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen, C 1-4 alkoxy (e.g., C 1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C 1-4 alkyl-NH- (e.g., C 1-3 alkyl-NH-, such as CH 3 NH-, CH 3 CH 2 NH- or CH 3 CH 2 CH 2 NH-), halogenated C 1-4 alkyl (e.g., halogenated C 1-3 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), NH 2 -C 1-4 alkylene (e.g., NH 2 -C 1-3 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - and NH 2 CH 2 CH 2 CH 2 -), C 1-4 alkyl-NHC(O)- (e.g., C 1-3 alkyl-NHC(O)-, such as CH 3 -NHC(O)-, CH 3 CH 2 -NHC(O)-, and CH 3 CH 2 CH 2 -NHC(O)-), C 1-4 alkyl-C(O)NH-(e.g., C 1-3 alkyl-C(O)NH-, such as CH 3 -C(O)NH-, CH 3 CH 2 -C(O)NH-, and CH 3 CH 2 CH 2 -C(O)NH-), cyano or any combination thereof, and the linear or branched C 2-60 alkylene is optionally substituted with one or more substituents selected from the group consisting of D, C 1-4 alkyl (e.g., C 1-3 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), halogen, C 3-6 cycloalkyl or any combination thereof; X 4 represents a bond, or X 4 represents N(R 15 ), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O) 2 , S(O) 2 NH, NHS(O) 2 , S(O) 2 O, OS(O) 2 , optionally substituted C 3-20 cycloalkylene, optionally substituted C 6-20 arylene, optionally substituted 4- to 20-membered heterocyclylene, optionally substituted 5- to 20-membered heteroarylene, triazolylene-NH-, or -NH-triazolylene, wherein R 15 represents H or C 1-3 alkyl, and the C 3-20 cycloalkylene, the C 6-20 arylene, the 4- to 20-membered heterocyclylene, and the 5- to 20-membered heteroarylene are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, optionally deuterated C 1-4 alkyl (e.g., optionally deuterated C 1-3 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), hydroxy, amino, mercapto, cyano, C 1-4 alkoxy (e.g., C 1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C 1-4 alkyl-NH- (e.g., C 1-3 alkyl-NH-, such as CH 3 NH-, CH 3 CH 2 NH- or CH 3 CH 2 CH 2 NH-), halogenated C 1-4 alkyl (e.g., halogenated C 1-3 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), NH 2 -C 1-4 alkylene (e.g., NH 2 -C 1-3 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - and NH 2 CH 2 CH 2 CH 2 -), C 1-4 alkyl-NHC(O)- (e.g., C 1-3 alkyl-NHC(O)-, such as CH 3 -NHC(O)-, CH 3 CH 2 -NHC(O)-, and CH 3 CH 2 CH 2 -NHC(O)-), C 1-4 alkyl-C(O)NH- (e.g., C 1-3 alkyl-C(O)NH-, such as CH 3 -C(O)NH-, CH 3 CH 2 -C(O)NH-, and CH 3 CH 2 CH 2 -C(O)NH-), or any combination thereof; and R 11 represents optionally substituted C 3-20 cycloalkyl, optionally substituted C 6-20 aryl, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted 5- to 20-membered heteroaryl, wherein the C 3-20 cycloalkyl, the C 6-20 aryl, the 4- to 20-membered heterocyclyl, and the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C 1-4 alkyl (e.g., optionally deuterated C 1-3 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally substituted C 3-15 cycloalkyl (e.g., optionally substituted cyclopropyl, optionally substituted cyclobutyl, optionally substituted cyclopentyl or optionally substituted cyclohexyl), optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C 6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C 1-4 alkoxy (e.g., C 1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C 1-4 alkyl-NH- (e.g., C 1-3 alkyl-NH-, such as CH 3 NH-, CH 3 CH 2 NH- or CH 3 CH 2 CH 2 NH-), halogenated C 1-4 alkyl (e.g., halogenated C 1-3 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), NH 2 -C 1-4 alkylene (e.g., NH 2 -C 1-3 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - and NH 2 CH 2 CH 2 CH 2 -), C 1-4 alkyl-NHC(O)- (e.g., C 1-3 alkyl-NHC(O)-, such as CH 3 -NHC(O)-, CH 3 CH 2 -NHC(O)-, and CH 3 CH 2 CH 2 -NHC(O)-), C 1-4 alkyl-C(O)NH- (e.g., C 1-3 alkyl-C(O)NH-, such as CH 3 -C(O)NH-, CH 3 CH 2 -C(O)NH-, and CH 3 CH 2 CH 2 -C(O)NH-), or any combination thereof; and the C 3-15 cycloalkyl, the 4- to 15-membered heterocyclyl, the C 6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C 1-4 alkyl (e.g., optionally deuterated C 1-3 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), hydroxy, amino, mercapto, halogen, cyano, C 1-4 alkoxy (e.g., C 1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C 1-4 alkyl-NH- (e.g., C 1-3 alkyl-NH-, such as CH 3 NH-, CH 3 CH 2 NH- or CH 3 CH 2 CH 2 NH-), halogenated C 1-4 alkyl (e.g., halogenated C 1-3 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), NH 2 -C 1-4 alkylene (e.g., NH 2 -C 1-3 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - and NH 2 CH 2 CH 2 CH 2 -), C 1-4 alkyl-NHC(O)- (e.g., C 1-3 alkyl-NHC(O)-, such as CH 3 -NHC(O)-, CH 3 CH 2 -NHC(O)-, and CH 3 CH 2 CH 2 -NHC(O)-), C 1-4 alkyl-C(O)NH-(e.g., C 1-3 alkyl-C(O)NH-, such as CH 3 -C(O)NH-, CH 3 CH 2 -C(O)NH-, and CH 3 CH 2 CH 2 -C(O)NH-), or any combination thereof. In embodiments of the present disclosure, the number of substituents is not theoretically limited in any way or automatically limited by the size of the building units.

[0038] In some embodiments of the compound of Formula (I-1), L 2 represents the structure of the following formula: -C 2-30 alkylene-, wherein a hydrogen atom of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) CH 2 groups of the C 2-30 alkylene is optionally replaced with a substituent selected from the group consisting of: D, C 1-4 alkyl, halogen, C 3-6 cycloalkyl or any combination thereof.

[0039] In some embodiments of the compound of Formula (I-1), L 2 represents the following group: -CH 2 -, -(CH 2 ) 2 -, -(CH 2 ) 3 -, -(CH 2 ) 4 -, -(CH 2 ) 5 -, -(CH 2 ) 2 -CF 2 -(CH 2 ) 2 -, -(CH 2 ) 6 -, -(CH 2 ) 7 -, -(CH 2 ) 8 -, - (CH 2 ) 9 -, -(CH 2 ) 10 -, -(CH 2 ) 11 -, -(CH 2 ) 12 -, -(CH 2 ) 13 -, -(CH 2 ) 14 -, -(CH 2 ) 15 -, -(CH 2 ) 16 -, -(CH 2 ) 17 -, - (CH 2 ) 18 -, -(CH 2 ) 19 -, -(CH 2 ) 20 -, -(CH 2 ) 21 -, -(CH 2 ) 22 -, -(CH 2 ) 25 -, or -(CH 2 ) 30 -; wherein a hydrogen atom of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) CH 2 groups of the group is optionally replaced with a substituent selected from the group consisting of: D, C 1-4 alkyl, halogen, C 3-6 cycloalkyl or any combination thereof.

[0040] In some embodiments of the compound of Formula (I-1), L 2 represents the structure of the following formula:         -(C(R a9< )(R a10< )) m1 -(R 12 (C(R a11< )(R a12< )) m2 ) p1 -;         -(C(R a9< )(R a10< )) m1 -(R 12 (C(R a11< )(R a12< )) m2 ) p1 -(R 12 (C(R a13< )(R a14< )) m3 ) p2 -;         -(C(R a9< )(R a10< )) m1 -(R 12 (C(R a11< )(R a12< )) m2 ) p1 -(R 12 (C(R a13< )(R a14< )) m3 ) p2 -(R 12 (C(R 15< )(R a16< )) m4 ) p3 -;         -(C(R a9< )(R a10< )) m1 -(R 13 (C(R a11< )(R a12< )) m2 ) p1 -;         -(C(R a9< )(R a10< )) m1 -(R 13 (C(R a11< )(R a12< )) m2 ) p1 -(R 13 (C(R a13< )(R a14< )) m3 ) p2 -;         -(C(R a9< )(R a10< )) m1 -(R 13 (C(R a11< )(R a12< )) m2 ) p1 -(R 13 (C(R a13< )(R a14< )) m3 ) p2 -(R 13 (C(R 15< )(R a16< )) m4 ) p3 -;         -(C(R a9< )(R a10< )) m1 -(R 12 -R 13 -(C(R a11< )(R a12< )) m2 ) p1 -;         -(C(R a9< )(R a10< )) m1 -(R 12 (C(R a11< )(R a12< )) m2 ) p1 -(R 13 (C(R a13< )(R a14< )) m3 ) p2 -; -(C(R a9< )(R a10< )) m1 -(R 12 -R 12 -(C(R a11< )(R a12< )) m2 ) p1 -; or         -(C(R a9< )(R a10< )) m1 -(R 13 (C(R a11< )(R a12< )) m2 ) p1 -(R 12 (C(R a13< )(R a14< )) m3 ) p2 -; wherein each group R 12 is independently selected from the group consisting of O, S, N(R 14 ), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O) 2 , S(O) 2 O, OS(O) 2 , S(O) 2 NH or NHS(O) 2 , wherein each R 14 independently represents H or C 1-3 alkyl; and each group R 13 is independently selected from the group consisting of optionally substituted C 3-15 cycloalkylene, optionally substituted 4- to 15-membered heterocyclylene, optionally substituted C 6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C 2-6 alkenylene, C 2-6 alkynylene or any combination thereof, wherein the C 3-15 cycloalkylene, the C 6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C 1-4 alkyl (e.g., optionally deuterated C 1-3 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C 3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen, cyano, C 1-4 alkoxy (e.g., C 1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C 1-4 alkyl-NH- (e.g., C 1-3 alkyl-NH-, such as CH 3 NH-, CH 3 CH 2 NH- or CH 3 CH 2 CH 2 NH-), halogenated C 1-4 alkyl (e.g., halogenated C 1-3 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), NH 2 -C 1-4 alkylene (e.g., NH 2 -C 1-3 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - and NH 2 CH 2 CH 2 CH 2 -), C 1-4 alkyl-NHC(O)- (e.g., C 1-3 alkyl-NHC(O)-, such as CH 3 -NHC(O)-, CH 3 CH 2 -NHC(O)-, and CH 3 CH 2 CH 2 -NHC(O)-), C 1-4 alkyl-C(O)NH- (e.g., C 1-3 alkyl-C(O)NH-, such as CH 3 -C(O)NH-, CH 3 CH 2 -C(O)NH-, and CH 3 CH 2 CH 2 -C(O)NH-) or any combination thereof; R a9< , R a10< , R a11< , R a12< , R a13< , R a14< , R a15< and R a16< each independently represent H, deuterium, halogen, C 1-4 alkyl, C 3-6 cycloalkyl or any combination thereof; and m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

[0041] In some embodiments of the compound of Formula (I-1), L 2 represents the structure of the following formula:         -(C(R a9< )(R a10< )) m1 -(O(C(R a11< )(R a12< )) m2 ) p1 -;         -(C(R a9< )(R a10< )) m1 -(O(C(R a11< )(R a12< )) m2 ) p1 -(O(C(R a13< )(R a14< ) m3 ) p2 -;         -(C(R a9< )(R a10< )) m1 -(O(C(R a11< )(R a12< )) m2 ) p1 -(O(C(R a13< )(R a14< ) m3 ) p2 -(O(C(R a15< )(R a16< ) m4 ) p3 ;         -(C(R a9< )(R a10< )) m1 -(N(R g11 )C(R a11< )(R a12< )) m2 ) p1 -;         -(C(R a9< )(R a10< )) m1 -(N(R g11 )(C(R a11< )(R a12< )) m2 ) p1 -(N(R g11 )(C(R a13< )(R a14< ) m3 ) p2 -;         -(C(R a9< )(R a10< )) m1 -(N(R g11 )(C(R a11< )(R a12< )) m2 ) p1 -(N(R g11 )(C(R a13< )(R a14< ) m3 ) p2 -(N(R g11 )(C(R a15< )(R a16< ) m4 ) p3 -;         -(C(R a9< )(R a10< )) m1 -(C(O)NH-(C(R a11< )(R a12< )) m2 ) p1 -;         -(C(R a9< )(R a10< )) m1 -(C(O)NH-(C(R a11< )(R a12< )) m2 ) p1 -(C(O)NH-(C(R a13< )(R a14< ) m3 ) p2 -         -(C(R a9< )(R a10< )) m1 -(C(O)NH-(C(R a11< )(R a12< )) m2 ) p1 -(C(O)NH-(C(R a13< )(R a14< ) m3 ) p2 -(C(O)NH-(C(R a15< )(R a16< ) m4 ) p3 -;         -(C(R a9< )(R a10< )) m1 -(C(O)NH-(C(R a11< )(R a12< )) m2 ) p1 -(O-(C(R a13< )(R a14< ) m3 ) p2 -;         -(C(R a9< )(R a10< )) m1 -(C(O)NH-(C(R a11< )(R a12< )) m2 )-(O(C(R a13< )(R a14< ) m3 ) p1 -;         -(C(R a9< )(R a10< )) m1 -(NHC(O)-(C(R a11< )(R a12< )) m2 ) p1 -;         -(C(R a9< )(R a10< )) m1 -(NHC(O)-(C(R a11< )(R a12< )) m2 )-(O(C(R a13< )(R a14< ) m3 ) p1 -;         -(C(R a9< )(R a10< )) m1 -(NHC(O)-(C(R a11< )(R a12< )) m2 ) p1 -(O(C(R a13< )(R a14< ) m3 ) p2 -(O(C(R a15< )(R a16< ) m4 ) p3 -;         -(C(R a9< )(R a10< )) m1 -(NHC(O)-(C(R a11< )(R a12< )) m2 ) p1 -(O(C(R a13< )(R a14< ) m3 ) p1 -;         -(C(R a9< )(R a10< )) m1 -(NHC(O)NH-(C(R a11< )(R a12< )) m2 -;         -(C(R a9< )(R a10< )) m1 -(C(O)-(C(R a11< )(R a12< )) m2 -;         -(C(R a9< )(R a10< )) m1 -(C(O)-(C(R a11< )(R a12< )) m2 -;         -(C(R a9< )(R a10< )) m1 -S-(C(R a11< )(R a12< )) m2 -;         -(C(R a9< )(R a10< )) m1 -(C 6-10 arylene-(C(R a11< )(R a12< )) m2 ) p1 -;         -(C(R a9< )(R a10< )) m1 -(C 6-10 arylene-(C(R a11< )(R a12< )) m2 ) p1 -(C 6-10 arylene-(C(R a13< )(R a14< )) m3 -;         -(C(R a9< )(R a10< )) m1 -(4- to 15-membered heterocyclylene-(C(R a11< )(R a12< )) m2 ) p1 -;         -(C(R a9< )(R a10< )) m1 -(4- to 15-membered heterocyclylene-(C(R a11< )(R a12< )) m2 ) p1 -(4- to 15-membered heterocyclylene-(C(R a13< )(R a14< )) m3 ) p2 -;         -(C(R a9< )(R a10< )) m1 -(5- to 15-membered heterocyclylene-(C(R a11< )(R a12< )) m2 ) p1 -;         -(C(R a9< )(R a10< )) m1 -(5- to 15-membered heterocyclylene-(C(R a11< )(R a12< )) m2 ) p1 -(5- to 15-membered heteroarylene-(C(R a13< )(R a14< )) m3 ) p2 -;         -(C(R a9< )(R a10< )) m1 -(C 3-15 cycloalkylene-(C(R a11< )(R a12< )) m2 ) p1 -; or         -(C(R a9< )(R a10< )) m1 -(C 3-15 cycloalkylene-(C(R a11< )(R a12< )) m2 ) p1 -(C 3-15 cycloalkylene-(C(R a13< )(R a14< )) m3 ) p2 -; wherein each R g11 independently represents H or C 1-3 alkyl; the C 3-15 cycloalkylene, the C 6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C 1-4 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH- or any combination thereof; R a9< , R a10< , R a11< , R a12< , R a13< , R a14< , R a15< and R a16< each independently represent H, deuterium, halogen, C 1-4 alkyl, C 3-6 cycloalkyl or any combination thereof; and m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

[0042] In some embodiments of the compound of Formula (I-1), L 2 represents the structure of the following formula: -CH 2 -O-CH 2 -, -CH 2 -O-(CH 2 ) 2 -, -(CH 2 ) 1 -O-(CH 2 ) 3 -, -(CH 2 ) 1 -O-(CH 2 ) 4 -, -(CH 2 ) 1 -O-(CH 2 ) 5 -, - (CH 2 ) 1 -O-(CH 2 ) 6 -, -(CH 2 ) 1 -O-(CH 2 ) 7 -, -(CH 2 ) 1 -O-(CH 2 ) 8 -, -(CH 2 ) 1 -O-(CH 2 ) 9 -, -(CH 2 ) 1 -O-(CH 2 ) 10 -, - (CH 2 ) 2 -O-(CH 2 ) 1 -, -(CH 2 ) 2 -O-(CH 2 ) 2 -, -(CH 2 ) 2 -O-(CH 2 ) 3 -, -(CH 2 ) 2 -O-(CH 2 ) 4 -, -(CH 2 ) 2 -O-(CH 2 ) 5 -, - (CH 2 ) 2 -O-(CH 2 ) 6 -, -(CH 2 ) 2 -O-(CH 2 ) 7 -, -(CH 2 ) 2 -O-(CH 2 ) 8 -, -(CH 2 ) 2 -O-(CH 2 ) 9 -, -(CH 2 ) 2 -O-(CH 2 ) 10 -, - (CH 2 ) 2 -O-(CH 2 ) 11 -, -(CH 2 ) 2 -O-(CH 2 ) 12 -, -(CH 2 ) 3 -O-(CH 2 ) 1 -, -(CH 2 ) 3 -O-(CH 2 ) 2 -, -(CH 2 ) 3 -O-(CH 2 ) 3 -, - (CH 2 ) 3 -O-(CH 2 ) 4 -, -(CH 2 ) 3 -O-(CH 2 ) 5 -, -(CH 2 ) 3 -O-(CH 2 ) 6 -, -(CH 2 ) 3 -O-(CH 2 ) 7 -, -(CH 2 ) 4 -O-(CH 2 ) 1 -, - (CH 2 ) 4 -O-(CH 2 ) 2 -, -(CH 2 ) 4 -O-(CH 2 ) 3 -, -(CH 2 ) 4 -O-(CH 2 ) 4 -, -(CH 2 ) 4 -O-(CH 2 ) 5 -, -(CH 2 ) 4 -O-(CH 2 ) 6 -, - (CH 2 ) 5 -O-(CH 2 ) 1 -, -(CH 2 ) 5 -O-(CH 2 ) 2 -, -(CH 2 ) 5 -O-(CH 2 ) 3 -, -(CH 2 ) 5 -O-(CH 2 ) 4 -, -(CH 2 ) 5 -O-(CH 2 ) 5 -, - (CH 2 ) 6 -O-(CH 2 ) 1 -, -(CH 2 ) 6 -O-(CH 2 ) 2 -, -(CH 2 ) 6 -O-(CH 2 ) 3 -, -(CH 2 ) 6 -O-(CH 2 ) 4 -, -(CH 2 ) 7 -O-(CH 2 ) 1 -, - (CH 2 ) 7 -O-(CH 2 ) 2 -, -(CH 2 ) 7 -O-(CH 2 ) 3 -, -(CH 2 ) 8 -O-(CH 2 ) 1 -, -(CH 2 ) 8 -O-(CH 2 ) 2 -, -CH(CH 3 )-O-(CH 2 ) 1 -, - CH(CH 3 )-O-(CH 2 ) 2 -, -CH(CH 3 )-O-(CH 2 ) 3 -, -CH(CH 3 )-O-(CH 2 ) 4 -, -CH(CH 3 )-O-(CH 2 ) 5 -, -CH(CH 3 )-O-(CH 2 ) 6 -, -CH(CH 3 )-O-(CH 2 ) 7 -, -CH(CH 3 )-O-(CH 2 ) 8 -, -CH(CH 3 )-O-(CH 2 ) 9 -, -CH(CH 3 )-O-(CH 2 ) 10 -, -CH 2 -(O(CH 2 ) 2 ) 2 -, -CH 2 -(O(CH 2 ) 2 ) 3 -, -CH 2 -(O(CH 2 ) 2 ) 4 -, -CH 2 -(O(CH 2 ) 2 ) 5 -, -CH 2 -(O(CH 2 ) 2 ) 6 -, -CH 2 -(O(CH 2 ) 2 ) 7 -, -CH 2 -(O(CH 2 ) 2 ) 8 -, -CH 2 -(O(CH 2 ) 2 ) 9 -, -CH 2 -(O(CH 2 ) 2 ) 10 -, -CH 2 -(O(CH 2 ) 2 ) 1 -OCH 2 -, - CH 2 -(O(CH 2 ) 2 ) 2 -OCH 2 -, -CH 2 -(O(CH 2 ) 2 ) 3 -OCH 2 -, -CH 2 -(O(CH 2 ) 2 ) 4 -OCH 2 -, -CH 2 -(O(CH 2 ) 2 ) 5 -OCH 2 -, -CH 2 -(O(CH 2 ) 2 ) 6 -OCH 2 -, -CH 2 -(O(CH 2 ) 2 ) 7 -OCH 2 -, -CH 2 -(O(CH 2 ) 2 ) 8 -OCH 2 -, -CH 2 -(O(CH 2 ) 2 ) 9 -OCH 2 -, -CH 2 -(O(CH 2 ) 2 ) 10 -OCH 2 -, -(CH 2 ) 2 -(O(CH 2 ) 2 ) 2 -, -(CH 2 ) 2 -(O(CH 2 ) 2 ) 3 -, -(CH 2 ) 2 -(O(CH 2 ) 2 ) 4 -, - (CH 2 ) 2 -(O(CH 2 ) 2 ) 5 -, -(CH 2 ) 2 -(O(CH 2 ) 2 ) 6 -, -(CH 2 ) 2 -(O(CH 2 ) 2 ) 7 -, -(CH 2 ) 2 -(O(CH 2 ) 2 ) 8 -, -(CH 2 ) 2 -(O(CH 2 ) 2 ) 9 -, -(CH 2 ) 2 -(O(CH 2 ) 2 ) 10 -, -(CH 2 ) 3 -(O(CH 2 ) 2 ) 2 -, -(CH 2 ) 3 -(O(CH 2 ) 2 ) 3 -, -(CH 2 ) 3 -(O(CH 2 ) 2 ) 4 -, - (CH 2 ) 3 -(O(CH 2 ) 2 ) 5 -, -(CH 2 ) 3 -(O(CH 2 ) 2 ) 6 -, -(CH 2 ) 3 -(O(CH 2 ) 2 ) 7 -, -(CH 2 ) 3 -(O(CH 2 ) 2 ) 8 -, -(CH 2 ) 3 -(O(CH 2 ) 2 ) 9 -, -(CH 2 ) 3 -(O(CH 2 ) 2 ) 10 -, -(CH 2 ) 4 -(O(CH 2 ) 2 ) 2 -, -(CH 2 ) 4 -(O(CH 2 ) 2 ) 3 -, -(CH 2 ) 4 -(O(CH 2 ) 2 ) 4 -, - (CH 2 ) 4 -(O(CH 2 ) 2 ) 5 -, -(CH 2 ) 4 -(O(CH 2 ) 2 ) 6 -, -(CH 2 ) 4 -(O(CH 2 ) 2 ) 7 -, -(CH 2 ) 4 -(O(CH 2 ) 2 ) 8 -, -(CH 2 ) 4 -(O(CH 2 ) 2 ) 9 -, -(CH 2 ) 4 -(O(CH 2 ) 2 ) 10 -, -CH 2 -(O(CH 2 ) 3 ) 2 -, -CH 2 -(O(CH 2 ) 3 ) 3 -, -CH 2 -(O(CH 2 ) 3 ) 4 -, -CH 2 -(O(CH 2 ) 3 ) 5 -, -CH 2 -(O(CH 2 ) 3 ) 6 -, -CH 2 -(O(CH 2 ) 3 ) 7 -, -CH 2 -(O(CH 2 ) 3 ) 8 -, -CH 2 -(O(CH 2 ) 3 ) 9 -, -CH 2 -(O(CH 2 ) 3 ) 10 -, -(CH 2 ) 2 -(O(CH 2 ) 3 ) 2 -, -(CH 2 ) 2 -(O(CH 2 ) 3 ) 3 -, -(CH 2 ) 2 -(O(CH 2 ) 3 ) 4 -, -(CH 2 ) 2 -(O(CH 2 ) 3 ) 5 -, - (CH 2 ) 2 -(O(CH 2 ) 3 ) 6 -, -(CH 2 ) 2 -(O(CH 2 ) 3 ) 7 -, -(CH 2 ) 2 -(O(CH 2 ) 3 ) 8 -, -(CH 2 ) 2 -(O(CH 2 ) 3 ) 9 -, -(CH 2 ) 2 -(O(CH 2 ) 3 ) 10 -, -(CH 2 ) 3 -(O(CH 2 ) 3 ) 2 -, -(CH 2 ) 3 -(O(CH 2 ) 3 ) 3 -, -(CH 2 ) 3 -(O(CH 2 ) 3 ) 4 -, -(CH 2 ) 3 -(O(CH 2 ) 3 ) 5 -, - (CH 2 ) 3 -(O(CH 2 ) 3 ) 6 -, -(CH 2 ) 3 -(O(CH 2 ) 3 ) 7 -, -(CH 2 ) 3 -(O(CH 2 ) 3 ) 8 -, -(CH 2 ) 3 -(O(CH 2 ) 3 ) 9 -, -(CH 2 ) 3 -(O(CH 2 ) 3 ) 10 -, -CH 2 -O-(CH 2 ) 2 -O-(CH 2 ) 3 -, -CH 2 -(O(CH 2 ) 2 ) 2 -(O(CH 2 ) 3 ) 2 -, -CH 2 -(O(CH 2 ) 2 ) 3 -(O(CH 2 ) 3 ) 3 -, -CH 2 -(O(CH 2 ) 2 ) 4 -(O(CH 2 ) 3 ) 4 -, -CH 2 -(O(CH 2 ) 2 ) 5 -(O(CH 2 ) 3 ) 5 -, -CH 2 -(O(CH 2 ) 2 ) 6 -(O(CH 2 ) 3 ) 6 -, -(CH 2 ) 2 -O-(CH 2 ) 2 -O-(CH 2 ) 3 -, -(CH 2 ) 2 -(O(CH 2 ) 2 ) 2 -(O(CH 2 ) 3 ) 2 -, -(CH 2 ) 2 -(O(CH 2 ) 2 ) 3 -(O(CH 2 ) 3 ) 3 -, -(CH 2 ) 2 -(O(CH 2 ) 2 ) 4 -(O(CH 2 ) 3 ) 4 -, -(CH 2 ) 2 -(O(CH 2 ) 2 ) 5 -(O(CH 2 ) 3 ) 5 -, -(CH 2 ) 2 -(O(CH 2 ) 2 ) 6 -(O(CH 2 ) 3 ) 6 -, -(CH 2 ) 3 -O-(CH 2 ) 2 -O-(CH 2 ) 3 -, -(CH 2 ) 3 -(O(CH 2 ) 2 ) 2 -(O(CH 2 ) 3 ) 2 -, -(CH 2 ) 3 -(O(CH 2 ) 2 ) 3 -(O(CH 2 ) 3 ) 3 -, -(CH 2 ) 3 -(O(CH 2 ) 2 ) 4 -(O(CH 2 ) 3 ) 4 -, -(CH 2 ) 3 -(O(CH 2 ) 2 ) 5 -(O(CH 2 ) 3 ) 5 -, -(CH 2 ) 3 -(O(CH 2 ) 2 ) 6 -(O(CH 2 ) 3 ) 6 -, -CH 2 -O-(CH 2 ) 3 -O-(CH 2 ) 2 -, -CH 2 -(O(CH 2 ) 3 ) 2 -(O(CH 2 ) 2 ) 2 -, -CH 2 -(O(CH 2 ) 3 ) 3 -(O(CH 2 ) 2 ) 3 -, -CH 2 -(O(CH 2 ) 3 ) 4 -(O(CH 2 ) 2 ) 4 -, -CH 2 -(O(CH 2 ) 3 ) 5 -(O(CH 2 ) 2 ) 5 -, -CH 2 -(O(CH 2 ) 3 ) 6 -(O(CH 2 ) 2 ) 6 -, -(CH 2 ) 2 -O-(CH 2 ) 3 -O-(CH 2 ) 2 -, -(CH 2 ) 2 -(O(CH 2 ) 3 ) 2 -(O(CH 2 ) 2 ) 2 -, -(CH 2 ) 2 -(O(CH 2 ) 3 ) 3 -(O(CH 2 ) 2 ) 3 -, -(CH 2 ) 2 -(O(CH 2 ) 3 ) 4 -(O(CH 2 ) 2 ) 4 -, -(CH 2 ) 2 -(O(CH 2 ) 3 ) 5 -(O(CH 2 ) 2 ) 5 -, -(CH 2 ) 2 -(O(CH 2 ) 3 ) 6 -(O(CH 2 ) 2 ) 6 -, -(CH 2 ) 3 -O-(CH 2 ) 3 -O-(CH 2 ) 2 -, -(CH 2 ) 3 -(O(CH 2 ) 3 ) 2 -(O(CH 2 ) 2 ) 2 -, -(CH 2 ) 3 -(O(CH 2 ) 3 ) 3 -(O(CH 2 ) 2 ) 3 -, -(CH 2 ) 3 -(O(CH 2 ) 3 ) 4 -(O(CH 2 ) 2 ) 4 -, -(CH 2 ) 3 -(O(CH 2 ) 3 ) 5 -(O(CH 2 ) 2 ) 5 -, -(CH 2 ) 3 -(O(CH 2 ) 3 ) 6 -(O(CH 2 ) 2 ) 6 -, -CH 2 -O-(CH 2 ) 2 -O-CH 2 -, -(CH 2 ) 2 -O-(CH 2 ) 2 -O-CH 2 -, -(CH 2 ) 2 -(O(CH 2 ) 2 ) 2 -O-(CH 2 ) 3 -, -(CH 2 ) 2 -(O(CH 2 ) 2 ) 3 -O-(CH 2 ) 3 -, - (CH 2 ) 2 -(O(CH 2 ) 2 ) 4 -O-(CH 2 ) 3 -, -(CH 2 ) 5 -(O(CH 2 ) 2 ) 2 -O-(CH 2 ) 5 -, -(CH 2 ) 5 -(O(CH 2 ) 2 ) 2 -O-(CH 2 ) 6 -, -CH 2 -C(O)-CH 2 -, -CH 2 -C(O)-(CH 2 ) 2 -, -(CH 2 ) 1 -C(O)-(CH 2 ) 3 -, -(CH 2 ) 1 -C(O)-(CH 2 ) 4 -, -(CH 2 ) 1 -C(O)-(CH 2 ) 5 -, -(CH 2 ) 1 -C(O)-(CH 2 ) 6 -, -(CH 2 ) 1 -C(O)-(CH 2 ) 7 -, -(CH 2 ) 1 -C(O)-(CH 2 ) 8 -, -(CH 2 ) 1 -C(O)-(CH 2 ) 9 -, -(CH 2 ) 1 -C(O)-(CH 2 ) 10 -, -(CH 2 ) 2 -C(O)-(CH 2 ) 1 -, -(CH 2 ) 2 -C(O)-(CH 2 ) 2 -, -(CH 2 ) 2 -C(O)-(CH 2 ) 3 -, -(CH 2 ) 2 -C(O)-(CH 2 ) 4 -, -(CH 2 ) 2 -C(O)-(CH 2 ) 5 -, -(CH 2 ) 2 -C(O)-(CH 2 ) 6 -, -(CH 2 ) 2 -C(O)-(CH 2 ) 7 -, -(CH 2 ) 2 -C(O)-(CH 2 ) 8 -, - (CH 2 ) 2 -C(O)-(CH 2 ) 9 -, -(CH 2 ) 2 -C(O)-(CH 2 ) 10 -, -(CH 2 ) 2 -C(O)-(CH 2 ) 11 -, -(CH 2 ) 2 -C(O)-(CH 2 ) 12 -, - (CH 2 ) 3 -C(O)-(CH 2 ) 1 -, -(CH 2 ) 3 -C(O)-(CH 2 ) 2 -, -(CH 2 ) 3 -C(O)-(CH 2 ) 3 -, -(CH 2 ) 3 -C(O)-(CH 2 ) 4 -, -(CH 2 ) 3 -C(O)-(CH 2 ) 5 -, -(CH 2 ) 3 -C(O)-(CH 2 ) 6 -, -(CH 2 ) 3 -C(O)-(CH 2 ) 7 -, -(CH 2 ) 4 -C(O)-(CH 2 ) 1 -, -(CH 2 ) 4 -C(O)-(CH 2 ) 2 -, -(CH 2 ) 4 -C(O)-(CH 2 ) 3 -, -(CH 2 ) 4 -C(O)-(CH 2 ) 4 -, -(CH 2 ) 4 -C(O)-(CH 2 ) 5 -, -(CH 2 ) 4 -C(O)-(CH 2 ) 6 -, - (CH 2 ) 5 -C(O)-(CH 2 ) 1 -, -(CH 2 ) 5 -C(O)-(CH 2 ) 2 -, -(CH 2 ) 5 -C(O)-(CH 2 ) 3 -, -(CH 2 ) 5 -C(O)-(CH 2 ) 4 -, -(CH 2 ) 5 -C(O)-(CH 2 ) 5 -, -(CH 2 ) 6 -C(O)-(CH 2 ) 1 -, -(CH 2 ) 6 -C(O)-(CH 2 ) 2 -, -(CH 2 ) 6 -C(O)-(CH 2 ) 3 -, -(CH 2 ) 6 -C(O)-(CH 2 ) 4 -, -(CH 2 ) 7 -C(O)-(CH 2 ) 1 -, -(CH 2 ) 7 -C(O)-(CH 2 ) 2 -, -(CH 2 ) 7 -C(O)-(CH 2 ) 3 -, -(CH 2 ) 8 -C(O)-(CH 2 ) 1 -, - (CH 2 ) 8 -C(O)-(CH 2 ) 2 -, -CH 2 -S-CH 2 -, -CH 2 -S-(CH 2 ) 2 -, -(CH 2 ) 1 -S-(CH 2 ) 3 -, -(CH 2 ) 1 -S-(CH 2 ) 4 -, -(CH 2 ) 1 -S-(CH 2 ) 5 -, -(CH 2 ) 1 -S-(CH 2 ) 6 -, -(CH 2 ) l -S-(CH 2 ) 7 -, -(CH 2 ) 1 -S-(CH 2 ) 8 -, -(CH 2 ) 1 -S-(CH 2 ) 9 -, -(CH 2 ) 1 -S-(CH 2 ) 10 -, -(CH 2 ) 2 -S-(CH 2 ) 1 -, -(CH 2 ) 2 -S-(CH 2 ) 2 -, -(CH 2 ) 2 -S-(CH 2 ) 3 -, -(CH 2 ) 2 -S-(CH 2 ) 4 -, -(CH 2 ) 2 -S-(CH 2 ) 5 -, -(CH 2 ) 2 -S-(CH 2 ) 6 -, -(CH 2 ) 2 -S-(CH 2 ) 7 -, -(CH 2 ) 2 -S-(CH 2 ) 8 -, -(CH 2 ) 2 -S-(CH 2 ) 9 -, -(CH 2 ) 2 -S-(CH 2 ) lO -, -(CH 2 ) 2 -S-(CH 2 ) 11 -, -(CH 2 ) 2 -S-(CH 2 ) 12 -, -(CH 2 ) 3 -S-(CH 2 ) 1 -, -(CH 2 ) 3 -S-(CH 2 ) 2 -, -(CH 2 ) 3 -S-(CH 2 ) 3 -, -(CH 2 ) 3 -S-(CH 2 ) 4 -, -(CH 2 ) 3 -S-(CH 2 ) 5 -, -(CH 2 ) 3 -S-(CH 2 ) 6 -, -(CH 2 ) 3 -S-(CH 2 ) 7 -, -(CH 2 ) 4 -S-(CH 2 ) l -, -(CH 2 ) 4 -S-(CH 2 ) 2 -, -(CH 2 ) 4 -S-(CH 2 ) 3 -, -(CH 2 ) 4 -S-(CH 2 ) 4 -, -(CH 2 ) 4 -S-(CH 2 ) 5 -, -(CH 2 ) 4 -S-(CH 2 ) 6 -, -(CH 2 ) 5 -S-(CH 2 ) 1 -, -(CH 2 ) 5 -S-(CH 2 ) 2 -, -(CH 2 ) 5 -S-(CH 2 ) 3 -, -(CH 2 ) 5 -S-(CH 2 ) 4 -, -(CH 2 ) 5 -S-(CH 2 ) 5 -, -(CH 2 ) 6 -S-(CH 2 ) 1 -, -(CH 2 ) 6 -S-(CH 2 ) 2 -, -(CH 2 ) 6 -S-(CH 2 ) 3 -, -(CH 2 ) 6 -S-(CH 2 ) 4 -, -(CH 2 ) 7 -S-(CH 2 ) 1 -, -(CH 2 ) 7 -S-(CH 2 ) 2 -, -(CH 2 ) 7 -S-(CH 2 ) 3 -, -(CH 2 ) 8 -S-(CH 2 ) I -, -(CH 2 ) 8 -S-(CH 2 ) 2 -, -CH 2 -C(S)-CH 2 -, -CH 2 -C(S)-(CH 2 ) 2 -, -(CH 2 ) 1 -C(S)-(CH 2 ) 3 -, -(CH 2 ) 1 -C(S)-(CH 2 ) 4 -, -(CH 2 ) 1 -C(S)-(CH 2 ) 5 -, - (CH 2 ) 1 -C(S)-(CH 2 ) 6 -, -(CH 2 ) 1 -C(S)-(CH 2 ) 7 -, -(CH 2 ) 1 -C(S)-(CH 2 ) 8 -, -(CH 2 ) 1 -C(S)-(CH 2 ) 9 -, -(CH 2 ) 1 -C(S)-(CH 2 ) 10 -, -(CH 2 ) 2 -C(S)-(CH 2 ) 1 -, -(CH 2 ) 2 -C(S)-(CH 2 ) 2 -, -(CH 2 ) 2 -C(S)-(CH 2 ) 3 -, -(CH 2 ) 2 -C(S)-(CH 2 ) 4 -, -(CH 2 ) 2 -C(S)-(CH 2 ) 5 -, -(CH 2 ) 2 -C(S)-(CH 2 ) 6 -, -(CH 2 ) 2 -C(S)-(CH 2 ) 7 -, -(CH 2 ) 2 -C(S)-(CH 2 ) 8 -, - (CH 2 ) 2 -C(S)-(CH 2 ) 9 -, -(CH 2 ) 2 -C(S)-(CH 2 ) 10 -, -(CH 2 ) 2 -C(S)-(CH 2 ) 11 -, -(CH 2 ) 2 -C(S)-(CH 2 ) 12 -, -(CH 2 ) 3 -C(S)-(CH 2 ) 1 -, -(CH 2 ) 3 -C(S)-(CH 2 ) 2 -, -(CH 2 ) 3 -C(S)-(CH 2 ) 3 -, -(CH 2 ) 3 -C(S)-(CH 2 ) 4 -, -(CH 2 ) 3 -C(S)-(CH 2 ) 5 -, -(CH 2 ) 3 -C(S)-(CH 2 ) 6 -, -(CH 2 ) 3 -C(S)-(CH 2 ) 7 -, -(CH 2 ) 4 -C(S)-(CH 2 ) 1 -, -(CH 2 ) 4 -C(S)-(CH 2 ) 2 -, - (CH 2 ) 4 -C(S)-(CH 2 ) 3 -, -(CH 2 ) 4 -C(S)-(CH 2 ) 4 -, -(CH 2 ) 4 -C(S)-(CH 2 ) 5 -, -(CH 2 ) 4 -C(S)-(CH 2 ) 6 -, -(CH 2 ) 5 -C(S)-(CH 2 ) 1 -, -(CH 2 ) 5 -C(S)-(CH 2 ) 2 -, -(CH 2 ) 5 -C(S)-(CH 2 ) 3 -, -(CH 2 ) 5 -C(S)-(CH 2 ) 4 -, -(CH 2 ) 5 -C(S)-(CH 2 ) 5 -, -(CH 2 ) 6 -C(S)-(CH 2 ) 1 -, -(CH 2 ) 6 -C(S)-(CH 2 ) 2 -, -(CH 2 ) 6 -C(S)-(CH 2 ) 3 -, -(CH 2 ) 6 -C(S)-(CH 2 ) 4 -, - (CH 2 ) 7 -C(S)-(CH 2 ) 1 -, -(CH 2 ) 7 -C(S)-(CH 2 ) 2 -, -(CH 2 ) 7 -C(S)-(CH 2 ) 3 -, -(CH 2 ) 8 -C(S)-(CH 2 ) 1 -, -(CH 2 ) 8 -C(S)-(CH 2 ) 2 -, -CH 2 -C(O)O-CH 2 -, -CH 2 -C(O)O-(CH 2 ) 2 -, -(CH 2 ) 1 -C(O)O-(CH 2 ) 3 -, -(CH 2 ) 1 -C(O)O-(CH 2 ) 4 -, -(CH 2 ) 1 -C(O)O-(CH 2 ) 5 -, -(CH 2 ) 1 -C(O)O-(CH 2 ) 6 -, -(CH 2 ) 1 -C(O)O-(CH 2 ) 7 -, -(CH 2 ) 1 -C(O)O-(CH 2 ) 8 -, -(CH 2 ) 1 -C(O)O-(CH 2 ) 9 -, -(CH 2 ) 1 -C(O)O-(CH 2 ) 10 -, -(CH 2 ) 2 -C(O)O-(CH 2 ) 1 -, -(CH 2 ) 2 -C(O)O-(CH 2 ) 2 -, -(CH 2 ) 2 -C(O)O-(CH 2 ) 3 -, -(CH 2 ) 2 -C(O)O-(CH 2 ) 4 -, -(CH 2 ) 2 -C(O)O-(CH 2 ) 5 -, -(CH 2 ) 2 -C(O)O-(CH 2 ) 6 -, -(CH 2 ) 2 -C(O)O-(CH 2 ) 7 -, -(CH 2 ) 2 -C(O)O-(CH 2 ) 8 -, -(CH 2 ) 2 -C(O)O-(CH 2 ) 9 -, -(CH 2 ) 2 -C(O)O-(CH 2 ) 10 -, -(CH 2 ) 2 -C(O)O-(CH 2 ) 11 -, -(CH 2 ) 2 -C(O)O-(CH 2 ) 12 -, -(CH 2 ) 3 -C(O)O-(CH 2 ) 1 -, -(CH 2 ) 3 -C(O)O-(CH 2 ) 2 -, -(CH 2 ) 3 -C(O)O-(CH 2 ) 3 -, -(CH 2 ) 3 -C(O)O-(CH 2 ) 4 -, -(CH 2 ) 3 -C(O)O-(CH 2 ) 5 -, -(CH 2 ) 3 -C(O)O-(CH 2 ) 6 -, -(CH 2 ) 3 -C(O)O-(CH 2 ) 7 -, -(CH 2 ) 4 -C(O)O-(CH 2 ) 1 -, -(CH 2 ) 4 -C(O)O-(CH 2 ) 2 -, -(CH 2 ) 4 -C(O)O-(CH 2 ) 3 -, -(CH 2 ) 4 -C(O)O-(CH 2 ) 4 -, -(CH 2 ) 4 -C(O)O-(CH 2 ) 5 -, -(CH 2 ) 4 -C(O)O-(CH 2 ) 6 -, -(CH 2 ) 5 -C(O)O-(CH 2 ) 1 -, -(CH 2 ) 5 -C(O)O-(CH 2 ) 2 -, -(CH 2 ) 5 -C(O)O-(CH 2 ) 3 -, -(CH 2 ) 5 -C(O)O-(CH 2 ) 4 -, -(CH 2 ) 5 -C(O)O-(CH 2 ) 5 -, -(CH 2 ) 6 -C(O)O-(CH 2 ) 1 -, -(CH 2 ) 6 -C(O)O-(CH 2 ) 2 -, -(CH 2 ) 6 -C(O)O-(CH 2 ) 3 -, -(CH 2 ) 6 -C(O)O-(CH 2 ) 4 -, -(CH 2 ) 7 -C(O)O-(CH 2 ) 1 -, -(CH 2 ) 7 -C(O)O-(CH 2 ) 2 -, -(CH 2 ) 7 -C(O)O-(CH 2 ) 3 -, -(CH 2 ) 8 -C(O)O-(CH 2 ) 1 -, -(CH 2 ) 8 -C(O)O-(CH 2 ) 2 -, -CH 2 -OC(O)-CH 2 -, -CH 2 -OC(O)-(CH 2 ) 2 -, -(CH 2 ) 1 -OC(O)-(CH 2 ) 3 -, - (CH 2 ) 1 -OC(O)-(CH 2 ) 4 -, -(CH 2 ) 1 -OC(O)-(CH 2 ) 5 -, -(CH 2 ) 1 -OC(O)-(CH 2 ) 6 -, -(CH 2 ) 1 -OC(O)-(CH 2 ) 7 -, - (CH 2 ) 1 -OC(O)-(CH 2 ) 8 -, -(CH 2 ) 1 -OC(O)-(CH 2 ) 9 -, -(CH 2 ) 1 -OC(O)-(CH 2 ) 10 -, -(CH 2 ) 2 -OC(O)-(CH 2 ) 1 -, - (CH 2 ) 2 -OC(O)-(CH 2 ) 2 -, -(CH 2 ) 2 -OC(O)-(CH 2 ) 3 -, -(CH 2 ) 2 -OC(O)-(CH 2 ) 4 -, -(CH 2 ) 2 -OC(O)-(CH 2 ) 5 -, - (CH 2 ) 2 -OC(O)-(CH 2 ) 6 -, -(CH 2 ) 2 -OC(O)-(CH 2 ) 7 -, -(CH 2 ) 2 -OC(O)-(CH 2 ) 8 -, -(CH 2 ) 2 -OC(O)-(CH 2 ) 9 -, - (CH 2 ) 2 -OC(O)-(CH 2 ) 10 -, -(CH 2 ) 2 -OC(O)-(CH 2 ) 11 -, -(CH 2 ) 2 -OC(O)-(CH 2 ) 12 -, -(CH 2 ) 3 -OC(O)-(CH 2 ) 1 -, - (CH 2 ) 3 -OC(O)-(CH 2 ) 2 -, -(CH 2 ) 3 -OC(O)-(CH 2 ) 3 -, -(CH 2 ) 3 -OC(O)-(CH 2 ) 4 -, -(CH 2 ) 3 -OC(O)-(CH 2 ) 5 -, - (CH 2 ) 3 -OC(O)-(CH 2 ) 6 -, -(CH 2 ) 3 -OC(O)-(CH 2 ) 7 -, -(CH 2 ) 4 -OC(O)-(CH 2 ) 1 -, -(CH 2 ) 4 -OC(O)-(CH 2 ) 2 -, - (CH 2 ) 4 -OC(O)-(CH 2 ) 3 -, -(CH 2 ) 4 -OC(O)-(CH 2 ) 4 -, -(CH 2 ) 4 -OC(O)-(CH 2 ) 5 -, -(CH 2 ) 4 -OC(O)-(CH 2 ) 6 -, - (CH 2 ) 5 -OC(O)-(CH 2 ) 1 -, -(CH 2 ) 5 -OC(O)-(CH 2 ) 2 -, -(CH 2 ) 5 -OC(O)-(CH 2 ) 3 -, -(CH 2 ) 5 -OC(O)-(CH 2 ) 4 -, - (CH 2 ) 5 -OC(O)-(CH 2 ) 5 -, -(CH 2 ) 6 -OC(O)-(CH 2 ) 1 -, -(CH 2 ) 6 -OC(O)-(CH 2 ) 2 -, -(CH 2 ) 6 -OC(O)-(CH 2 ) 3 -, - (CH 2 ) 6 -OC(O)-(CH 2 ) 4 -, -(CH 2 ) 7 -OC(O)-(CH 2 ) 1 -, -(CH 2 ) 7 -OC(O)-(CH 2 ) 2 -, -(CH 2 ) 7 -OC(O)-(CH 2 ) 3 -, - (CH 2 ) 8 -OC(O)-(CH 2 ) 1 -, -(CH 2 ) 8 -OC(O)-(CH 2 ) 2 -, -(CH 2 ) 1 -N(R g11 )-(CH 2 ) 1 -, -(CH Z ) 1 -N(R g11 )-(CH 2 ) 2 -, - (CH 2 ) 1 -N(R g11 )-(CH 2 ) 3 -, -(CH 2 ) 1 -N(R g11 )-(CH 2 ) 4 -, -(CH 2 ) 1 -N(R g11 )-(CH 2 ) 5 -, -(CH 2 ) 1 -N(R g11 )-(CH 2 ) 6 -, - (CH 2 ) 2 -N(R g11 )-(CH 2 ) 7 -, -(CH 2 ) 1 -N(R g11 )-(CH 2 ) 8 -, -(CH 2 ) 1 -N(R g11 )-(CH 2 ) 9 -, -(CH 2 ) 1 -N(R g11 )-(CH 2 ) 10 -, -(CH 2 ) 2 -N(R g11 )-(CH 2 ) 1 -, -(CH 2 ) 2 -N(R g11 )-(CH 2 ) 2 -, -(CH 2 ) 2 -N(R g11 )-(CH 2 ) 3 -, -(CH 2 ) 2 -N(R g11 )-(CH 2 ) 4 -, -(CH 2 ) 2 -N(R g11 )-(CH 2 ) 5 -, -(CH 2 ) 2 -N(R g11 )-(CH 2 ) 6 -, -(CH 2 ) 2 -N(R g11 )-(CH 2 ) 7 -, -(CH 2 ) 2 -N(R g11 )-(CH 2 ) 8 -, -(CH 2 ) 2 -N(R g11 )-(CH 2 ) 9 -, -(CH 2 ) 2 -N(R g11 -(CH 2 ) 10 -, -(CH 2 ) 2 -N(R g11 )-(CH 2 ) 11 -, -(CH a ) a -N(R g11 )-(CH 2 ) 12 -, -(CH 2 ) 3 -N(R g11 )-(CH 2 ) 1 -, -(CH 2 ) 3 -N(R g11 )-(CH 2 ) 2 -, -(CH 2 ) 3 -N(R g11 )-(CH 2 ) 3 -, -(CH 2 ) 4 -N(R g11 )-(CH 2 ) 1 -, -(CH 2 ) 4 -N(R g11 )-(CH 2 ) 2 -, -(CH 2 ) 4 -N(R g11 )-(CH 2 ) 3 -, -(CH 2 ) 4 -N(R g11 )-(CH 2 ) 4 -, -(CH 2 ) 5 -N(R g11 )-(CH 2 ) 1 -, -(CH 2 ) 5 -N(R g11 )-(CH 2 ) 2 -, -(CH 2 ) 5 -N(R g11 )-(CH 2 ) 3 -, -(CH 2 ) 5 -N(R g11 )-(CH 2 ) 4 -, -(CH 2 ) 5 -N(R g11 )-(CH 2 ) 5 -, -(CH 2 ) 6 -N(R g11 )-(CH 2 ) 1 -, -(CH 2 ) 6 -N(R g11 )-(CH 2 ) 2 -, -(CH 2 ) 6 -N(R g11 )-(CH 2 ) 3 -, -(CH 2 ) 7 -N(R g11 )-(CH 2 ) 1 -, -(CH 2 ) 7 -N(R g11 )-(CH 2 ) 2 -, -(CH 2 ) 7 -N(R g11 )-(CH 2 ) 3 -, -(CH 2 ) 8 -N(R g11 )-(CH 2 ) 1 -, -(CH 2 ) 8 -NR g11 )-(CH 2 ) 2 -, -(CH 2 ) 8 -N(R g11 )-(CH 2 ) 3 -, -CH(CH 3 )-N(R g11 )-(CH 2 ) 1 -, -CH(CH 3 )-N(R g11 )-(CH 2 ) 2 -, - CH(CH 3 )-N(R g11 )-(CH 2 ) 3 -, -CH(CH 3 )-N(R g11 )-(CH 2 ) 4 -, -CH(CH 3 )-N(R g11 )-(CH 2 ) 5 -, -CH(CH 3 )-N(R g11 )-(CH 2 ) 6 -, -CH(CH 3 )-N(R g11 )-(CH 2 ) 7 -, -CH(CH 3 )-N(R g11 )-(CH 2 ) 8 -, -CH(CH 3 )-N(R g11 )-(CH 2 ) 9 -, -CH(CH 3 )-N(R g11 )-(CH 2 ) 10 -, -CH 2 C(O)NHCH 2 -, -(CH 2 ) 2 C(O)NH(CH 2 ) 2 -, -(CH 2 ) 2 C(O)NH(CH 2 ) 3 -, - (CH 2 ) 2 C(O)NH(CH 2 ) 4 -, -(CH 2 ) 2 C(O)NH(CH 2 ) 5 -, -(CH 2 ) 3 C(O)NH(CH 2 ) 3 -, -(CH 2 ) 3 C(O)NH(CH 2 ) 4 -, - (CH 2 ) 4 C(O)NH(CH 2 ) 4 -, -(CH 2 ) 5 C(O)NH(CH 2 ) 5 -, -(CH 2 ) 6 C(O)NH(CH 2 ) 7 -, -(CH 2 ) 6 C(O)NH(CH 2 ) 6 -, - (CH 2 ) 7 C(O)NH(CH 2 ) 7 -, -(CH 2 ) 8 C(O)NH(CH 2 ) 8 , -(CH 2 ) 9 C(O)NH(CH 2 ) 9 -, -(CH 2 ) l oC(O)NH(CH 2 ) 10 -, - (CH 2 ) 2 C(O)NH(CH 2 ) 2 -O-(CH 2 ) 2 -, -CH 2 NHC(O)CH 2 -, -(CH 2 ) 2 NHC(O)(CH 2 ) 2 -, - (CH 2 ) 2 NHC(O)(CH 2 ) 3 -, -(CH 2 ) 2 NHC(O)(CH 2 ) 4 -, -(CH 2 ) 2 NHC(O)(CH 2 ) 5 -, -(CH 2 ) 3 NHC(O)(CH 2 ) 3 -, - (CH 2 ) 3 NHC(O)(CH 2 ) 4 -, -(CH 2 ) 4 NHC(O)(CH 2 ) 4 -, -(CH 2 ) 5 NHC(O)(CH 2 ) 5 -, -(CH 2 ) 6 NHC(O)(CH 2 ) 7 -, - (CH 2 ) 6 NHC(O)(CH 2 ) 6 -, -(CH 2 ) 7 NHC(O)(CH 2 ) 7 -, -(CH 2 ) 8 NHC(O)(CH 2 ) 8 , -(CH 2 ) 9 NHC(O)(CH 2 ) 9 -, - (CH 2 ) 10 NHC(O)(CH 2 ) 10 -, -(CH 2 ) 4 NHC(O)(CH 2 ) 8 -, -(CH 2 ) 2 NHC(O)(CH 2 ) 2 -O-(CH 2 ) 2 -, - (CH 2 ) 4 NHC(O)CH 2 -, -CH 2 -piperidinylene-CH 2 -, -CH 2 -piperidinylene-(CH 2 ) 2 -, -CH 2 -piperidinylene-(CH 2 ) 3 -, -CH 2 -piperidinylene-(CH 2 ) 4 -, -CH 2 -piperidinylene-(CH 2 ) 5 -, -CH 2 -piperidinylene-(CH 2 ) 6 -, - CH 2 -piperidinylene-(CH 2 ) 7 -, -CH 2 -piperidinylene-(CH 2 ) 8 -, -(CH 2 ) 2 -piperidinylene-(CH 2 ) 1 -, -(CH 2 ) 2 -piperidinylene-(CH 2 ) 2 -, -(CH 2 ) 2 -piperidinylene-(CH 2 ) 3 -, -(CH 2 ) 2 -piperidinylene-(CH 2 ) 4 -, -(CH 2 ) 2 -piperidinylene-(CH 2 ) 5 -, -(CH 2 ) 2 -piperidinylene-(CH 2 ) 6 -, -(CH 2 ) 2 -piperidinylene-(CH 2 ) 7 -, -(CH 2 ) 2 -piperidinylene-(CH 2 ) 8 -, -(CH 2 ) 3 -piperidinylene-CH 2 -, -(CH 2 ) 3 -piperidinylene-(CH 2 ) 2 -, -(CH 2 ) 3 -piperidinylene-(CH 2 ) 3 -, -(CH 2 ) 3 -piperidinylene-(CH 2 ) 4 -, -(CH 2 ) 3 -piperidinylene-(CH 2 ) 5 -, -(CH 2 ) 3 -piperidinylene-(CH 2 ) 6 -, -(CH 2 ) 3 -piperidinylene-(CH 2 ) 7 -, -(CH 2 ) 3 -piperidinylene-(CH 2 ) 8 -, -(CH 2 ) 4 -piperidinylene-CH 2 -, -(CH 2 ) 4 -piperidinylene-(CH 2 ) 2 -, -(CH 2 ) 4 -piperidinylene-(CH 2 ) 3 -, -(CH 2 ) 4 -piperidinylene-(CH 2 ) 4 -, -(CH 2 ) 4 -piperidinylene-(CH 2 ) 5 -, -(CH 2 ) 4 -piperidinylene-(CH 2 ) 6 -, -(CH 2 ) 4 -piperidinylene-(CH 2 ) 7 -, -(CH 2 ) 4 -piperidinylene-(CH 2 ) 8 -, -(CH 2 ) 5 -piperidinylene-(CH 2 ) 1 -, -(CH 2 ) 5 -piperidinylene-(CH 2 ) 2 -, -(CH 2 ) 5 -piperidinylene-(CH 2 ) 3 -, -(CH 2 ) 5 -piperidinylene-(CH 2 ) 4 -, -(CH 2 ) 5 -piperidinylene-(CH 2 ) 5 -, -(CH 2 ) 5 -piperidinylene-(CH 2 ) 6 -, -(CH 2 ) 5 -piperidinylene-(CH 2 ) 7 -, -(CH 2 ) 5 -piperidinylene-(CH 2 ) 8 -, -(CH 2 ) 6 -piperidinylene-(CH 2 ) 1 -, -(CH 2 ) 6 -piperidinylene-(CH 2 ) 2 -, -(CH 2 ) 6 -piperidinylene-(CH 2 ) 3 -, -(CH 2 ) 6 -piperidinylene-(CH 2 ) 4 -, -(CH 2 ) 6 -piperidinylene-(CH 2 ) 5 -, -(CH 2 ) 6 -piperidinylene-(CH 2 ) 6 -, -(CH 2 ) 6 -piperidinylene-(CH 2 ) 7 -, -(CH 2 ) 6 -piperidinylene-(CH 2 ) 8 -, -(CH 2 ) 7 -piperidinylene-(CH 2 ) 1 -, -(CH 2 ) 7 -piperidinylene-(CH 2 ) 2 -, -(CH 2 ) 7 -piperidinylene-(CH 2 ) 3 -, -(CH 2 ) 7 -piperidinylene-(CH 2 ) 4 -, -(CH 2 ) 7 -piperidinylene-(CH 2 ) 8 -, -(CH 2 ) 8 -piperidinylene-CH 2 -, -(CH 2 ) 8 -piperidinylene-(CH 2 ) 2 -, -(CH 2 ) 8 -piperidinylene-(CH 2 ) 3 -, -(CH 2 ) 8 -piperidinylene-(CH 2 ) 4 -, -(CH 2 ) 8 -piperidinylene-(CH 2 ) 5 -, -(CH 2 ) 8 -piperidinylene-(CH 2 ) 6 -, -(CH 2 ) 8 -piperidinylene-(CH 2 ) 7 -, -(CH 2 ) 8 -piperidinylene-(CH 2 ) 8 -, -CH 2 -piperazinylene-CH 2 -, -CH 2 -piperazinylene-(CH 2 ) 2 -, -CH 2 -piperazinylene-(CH 2 ) 3 -, -CH 2 -piperazinylene-(CH 2 ) 4 -, -CH 2 -piperazinylene-(CH 2 ) 5 -, -CH 2 -piperazinylene-(CH 2 ) 6 -, -CH 2 -piperazinylene-(CH 2 ) 7 -, -CH 2 -piperazinylene-(CH 2 ) 8 -, -(CH 2 ) 2 -piperazinylene-(CH 2 ) 1 -, -(CH 2 ) 2 -piperazinylene-(CH 2 ) 2 -, -(CH 2 ) 2 -piperazinylene-(CH 2 ) 3 -, -(CH 2 ) 2 -piperazinylene-(CH 2 ) 4 -, -(CH 2 ) 2 -piperazinylene-(CH 2 ) 5 -, -(CH 2 ) 2 -piperazinylene-(CH 2 ) 6 -, -(CH 2 ) 2 -piperazinylene-(CH 2 ) 7 -, -(CH 2 ) 2 -piperazinylene-(CH 2 ) 8 -, -(CH 2 ) 3 -piperazinylene-CH 2 -, -(CH 2 ) 3 -piperazinylene-(CH 2 ) 2 -, -(CH 2 ) 3 -piperazinylene-(CH 2 ) 3 -, -(CH 2 ) 3 -piperazinylene-(CH 2 ) 4 -, -(CH 2 ) 3 -piperazinylene-(CH 2 ) 5 -, -(CH 2 ) 3 -piperazinylene-(CH 2 ) 6 -, -(CH 2 ) 3 -piperazinylene-(CH 2 ) 7 -, -(CH 2 ) 3 -piperazinylene-(CH 2 ) 8 -, -(CH 2 ) 4 -piperazinylene-CH 2 -, -(CH 2 ) 4 -piperazinylene-(CH 2 ) 2 -, -(CH 2 ) 4 -piperazinylene-(CH 2 ) 3 -, -(CH 2 ) 4 -piperazinylene-(CH 2 ) 4 -, -(CH 2 ) 4 -piperazinylene-(CH 2 ) 5 -, -(CH 2 ) 4 -piperazinylene-(CH 2 ) 6 -, -(CH 2 ) 4 -piperazinylene-(CH 2 ) 7 -, -(CH 2 ) 4 -piperazinylene-(CH 2 ) 8 -, -(CH 2 ) 5 -piperazinylene-(CH 2 ) 1 -, -(CH 2 ) 5 -piperazinylene-(CH 2 ) 2 -, -(CH 2 ) 5 -piperazinylene-(CH 2 ) 3 -, -(CH 2 ) 5 -piperazinylene-(CH 2 ) 4 -, -(CH 2 ) 5 -piperazinylene-(CH 2 ) 5 -, -(CH 2 ) 5 -piperazinylene-(CH 2 ) 6 -, -(CH 2 ) 5 -piperazinylene-(CH 2 ) 7 -, -(CH 2 ) 5 -piperazinylene-(CH 2 ) 8 -, -(CH 2 ) 6 -piperazinylene-(CH 2 )i-, -(CH 2 ) 6 -piperazinylene-(CH 2 ) 2 -, -(CH 2 ) 6 -piperazinylene-(CH 2 ) 3 -, -(CH 2 ) 6 -piperazinylene-(CH 2 ) 4 -, -(CH 2 ) 6 -piperazinylene-(CH 2 ) 5 -, -(CH 2 ) 6 -piperazinylene-(CH 2 ) 6 -, -(CH 2 ) 6 -piperazinylene-(CH 2 ) 7 -, -(CH 2 ) 6 -piperazinylene-(CH 2 ) 8 -, -(CH 2 ) 7 -piperazinylene-(CH 2 ) 1 -, -(CH 2 ) 7 -piperazinylene-(CH 2 ) 2 -, -(CH 2 ) 7 -piperazinylene-(CH 2 ) 3 -, -(CH 2 ) 7 -piperazinylene-(CH 2 ) 4 -, -(CH 2 ) 7 -piperazinylene-(CH 2 ) 8 -, -(CH 2 ) 8 -piperazinylene-CH 2 -, -(CH 2 ) 8 -piperazinylene-(CH 2 ) 2 -, -(CH 2 ) 8 -piperazinylene-(CH 2 ) 3 -, -(CH 2 ) 8 -piperazinylene-(CH 2 ) 4 -, -(CH 2 ) 8 -piperazinylene-(CH 2 ) 5 -, -(CH 2 ) 8 -piperazinylene-(CH 2 ) 6 -, -(CH 2 ) 8 -piperazinylene-(CH 2 ) 7 -, -(CH 2 ) 8 -piperazinylene-(CH 2 ) 8 -, -CH 2 -propylene-CH 2 -, -CH 2 -propylene-(CH 2 ) 2 -, -CH 2 -propylene-(CH 2 ) 3 -, -CH 2 -propylene-(CH 2 ) 4 -, -CH 2 -propylene-(CH 2 ) 5 -, -CH 2 -propylene-(CH 2 ) 6 -, -CH 2 -propylene-(CH 2 ) 7 -, -CH 2 -propylene-(CH 2 ) 8 -, -(CH 2 ) 2 -propylene-(CH 2 ) 1 -, -(CH 2 ) 2 -propylene-(CH 2 ) 2 -, -(CH 2 ) 2 -propylene-(CH 2 ) 3 -, -(CH 2 ) 2 -propylene-(CH 2 ) 4 -, -(CH 2 ) 2 -propylene-(CH 2 ) 5 -, -(CH 2 ) 2 -propylene-(CH 2 ) 6 -, -(CH 2 ) 2 -propylene-(CH 2 ) 7 -, -(CH 2 ) 2 -propylene-(CH 2 ) 8 -, -(CH 2 ) 3 -propylene-CH 2 -, -(CH 2 ) 3 -propylene-(CH 2 ) 2 -, -(CH 2 ) 3 -propylene-(CH 2 ) 3 -, -(CH 2 ) 3 -propylene-(CH 2 ) 4 -, - (CH 2 ) 3 -propylene-(CH 2 ) 5 -, -(CH 2 ) 3 -propylene-(CH 2 ) 6 -, -(CH 2 ) 3 -propylene-(CH 2 ) 7 -, -(CH 2 ) 3 -propylene-(CH 2 ) 8 -, -(CH 2 ) 4 -propylene-CH 2 -, -(CH 2 ) 4 -propylene-(CH 2 ) 2 -, -(CH 2 ) 4 -propylene-(CH 2 ) 3 -, -(CH 2 ) 4 -propylene-(CH 2 ) 4 -, -(CH 2 ) 4 -propylene-(CH 2 ) 5 -, -(CH 2 ) 4 -propylene-(CH 2 ) 6 -, -(CH 2 ) 4 -propylene-(CH 2 ) 7 -, -(CH 2 ) 4 -propylene-(CH 2 ) 8 -, -(CH 2 ) 5 -propylene-(CH 2 ) 1 -, -(CH 2 ) 5 -propylene-(CH 2 ) 2 -, -(CH 2 ) 5 -propylene-(CH 2 ) 3 -, -(CH 2 ) 5 -propylene-(CH 2 ) 4 -, -(CH 2 ) 5 -propylene-(CH 2 ) 5 -, -(CH 2 ) 5 -propylene-(CH 2 ) 6 -, -(CH 2 ) 5 -propylene-(CH 2 ) 7 -, -(CH 2 ) 5 -propylene-(CH 2 ) 8 -, -(CH 2 ) 6 -propylene-(CH 2 ) 1 -, -(CH 2 ) 6 -propylene-(CH 2 ) 2 -, -(CH 2 ) 6 -propylene-(CH 2 ) 3 -, -(CH 2 ) 6 -propylene-(CH 2 ) 4 -, -(CH 2 ) 6 -propylene-(CH 2 ) 5 -, -(CH 2 ) 6 -propylene-(CH 2 ) 6 -, -(CH 2 ) 6 -propylene-(CH 2 ) 7 -, -(CH 2 ) 6 -propylene-(CH 2 ) 8 -, -(CH 2 ) 7 -propylene-(CH 2 ) 1 -, -(CH 2 ) 7 -propylene-(CH 2 ) 2 -, -(CH 2 ) 7 -propylene-(CH 2 ) 3 -, -(CH 2 ) 7 -propylene-(CH 2 ) 4 -, -(CH 2 ) 7 -propylene-(CH 2 ) 8 -, -(CH 2 ) 8 -propylene-CH 2 -, -(CH 2 ) 8 -propylene-(CH 2 ) 2 -, -(CH 2 ) 8 -propylene-(CH 2 ) 3 -, -(CH 2 ) 8 -propylene-(CH 2 ) 4 -, -(CH 2 ) 8 -propylene-(CH 2 ) 5 -, -(CH 2 ) 8 -propylene-(CH 2 ) 6 -, -(CH 2 ) 8 -propylene-(CH 2 ) 7 -, -(CH 2 ) 8 -propylene-(CH 2 ) 8 -, -CH 2 -diazacycloheptanylene-CH 2 -, -CH 2 -diazacycloheptanylene-(CH 2 ) 2 -, -CH 2 -diazacycloheptanylene-(CH 2 ) 3 -, -CH 2 -diazacycloheptanylene-(CH 2 ) 4 -, -CH 2 -diazacycloheptanylene-(CH 2 ) 5 -, -CH 2 -diazacycloheptanylene-(CH 2 ) 6 -, -CH 2 -diazacycloheptanylene-(CH 2 ) 7 -, -CH 2 -diazacycloheptanylene-(CH 2 ) 8 -, -(CH 2 ) 2 -diazacycloheptanylene-(CH 2 ) 1 -, -(CH 2 ) 2 -diazacycloheptanylene-(CH 2 ) 2 -, -(CH 2 ) 2 -diazacycloheptanylene-(CH 2 ) 3 -, -(CH 2 ) 2 -diazacycloheptanylene-(CH 2 ) 4 -, -(CH 2 ) 2 -diazacycloheptanylene-(CH 2 ) 5 -, -(CH 2 ) 2 -diazacycloheptanylene-(CH 2 ) 6 -, -(CH 2 ) 2 -diazacycloheptanylene-(CH 2 ) 7 -, -(CH 2 ) 2 -diazacycloheptanylene-(CH 2 ) 8 -, -(CH 2 ) 3 -diazacycloheptanylene-CH 2 -, -(CH 2 ) 3 -diazacycloheptanylene-(CH 2 ) 2 -, -(CH 2 ) 3 -diazacycloheptanylene-(CH 2 ) 3 -, -(CH 2 ) 3 -diazacycloheptanylene-(CH 2 ) 4 -, -(CH 2 ) 3 -diazacycloheptanylene-(CH 2 ) 5 -, -(CH 2 ) 3 -diazacycloheptanylene-(CH 2 ) 6 -, -(CH 2 ) 3 -diazacycloheptanylene-(CH 2 ) 7 -, -(CH 2 ) 3 -diazacycloheptanylene-(CH 2 ) 8 -, -(CH 2 ) 4 -diazacycloheptanylene-CH 2 -, -(CH 2 ) 4 -diazacycloheptanylene-(CH 2 ) 2 -, -(CH 2 ) 4 -diazacycloheptanylene-(CH 2 ) 3 -, -(CH 2 ) 4 -diazacycloheptanylene-(CH 2 ) 4 -, -(CH 2 ) 4 -diazacycloheptanylene-(CH 2 ) 5 -, -(CH 2 ) 4 -diazacycloheptanylene-(CH 2 ) 6 -, -(CH 2 ) 4 -diazacycloheptanylene-(CH 2 ) 7 -, -(CH 2 ) 4 -diazacycloheptanylene-(CH 2 ) 8 -, -(CH 2 ) 5 -diazacycloheptanylene-(CH 2 ) 1 -, -(CH 2 ) 5 -diazacycloheptanylene-(CH 2 ) 2 -, -(CH 2 ) 5 -diazacycloheptanylene-(CH 2 ) 3 -, -(CH 2 ) 5 -diazacycloheptanylene-(CH 2 ) 4 -, -(CH 2 ) 5 -diazacycloheptanylene-(CH 2 ) 5 -, -(CH 2 ) 5 -diazacycloheptanylene-(CH 2 ) 6 -, -(CH 2 ) 5 -diazacycloheptanylene-(CH 2 ) 7 -, -(CH 2 ) 5 -diazacycloheptanylene-(CH 2 ) 8 -, -(CH 2 ) 6 -diazacycloheptanylene-(CH 2 ) 1 -, -(CH 2 ) 6 -diazacycloheptanylene-(CH 2 ) 2 -, -(CH 2 ) 6 -diazacycloheptanylene-(CH 2 ) 3 -, -(CH 2 ) 6 -diazacycloheptanylene-(CH 2 ) 4 -, -(CH 2 ) 6 -diazacycloheptanylene-(CH 2 ) 5 -, -(CH 2 ) 6 -diazacycloheptanylene-(CH 2 ) 6 -, -(CH 2 ) 6 -diazacycloheptanylene-(CH 2 ) 7 -, -(CH 2 ) 6 -diazacycloheptanylene-(CH 2 ) 8 -, -(CH 2 ) 7 -diazacycloheptanylene-(CH 2 ) 1 -, -(CH 2 ) 7 -diazacycloheptanylene-(CH 2 ) 2 -, -(CH 2 ) 7 -diazacycloheptanylene-(CH 2 ) 3 -, -(CH 2 ) 7 -diazacycloheptanylene-(CH 2 ) 4 -, -(CH 2 ) 7 -diazacycloheptanylene-(CH 2 ) 8 -, -(CH 2 ) 8 -diazacycloheptanylene-CH 2 -, -(CH 2 ) 8 -diazacycloheptanylene-(CH 2 ) 2 -, -(CH 2 ) 8 -diazacycloheptanylene-(CH 2 ) 3 -, -(CH 2 ) 8 -diazacycloheptanylene-(CH 2 ) 4 -, -(CH 2 ) 8 -diazacycloheptanylene-(CH 2 ) 5 -, -(CH 2 ) 8 -diazacycloheptanylene-(CH 2 ) 6 -, -(CH 2 ) 8 -diazacycloheptanylene-(CH 2 ) 7 -, -(CH 2 ) 8 -diazacycloheptanylene-(CH 2 ) 8 -, -CH 2 -diazabicyclo[2.2.1]heptanylene-CH 2 -, -CH 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 2 -, -CH 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 3 -, -CH 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 4 -, -CH 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 5 -, -CH 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 6 -, -CH 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 7 -, -CH 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 8 -, -(CH 2 ) 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 1 -, -(CH 2 ) 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 2 -, -(CH 2 ) 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 3 -, -(CH 2 ) 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 4 -, -(CH 2 ) 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 5 -, -(CH 2 ) 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 6 -, -(CH 2 ) 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 7 -, -(CH 2 ) 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 8 -, -(CH 2 ) 3 -diazabicyclo[2.2.1]heptanylene-CH 2 -, -(CH 2 ) 3 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 2 -, -(CH 2 ) 3 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 3 -, -(CH 2 ) 3 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 4 -, -(CH 2 ) 3 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 5 -, -(CH 2 ) 3 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 6 -, -(CH 2 ) 3 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 7 -, -(CH 2 ) 3 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 8 -, -(CH 2 ) 4 -diazabicyclo[2.2.1]heptanylene-CH 2 -, -(CH 2 ) 4 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 2 -, -(CH 2 ) 4 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 3 -, -(CH 2 ) 4 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 4 -, -(CH 2 ) 4 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 5 -, -(CH 2 ) 4 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 6 -, -(CH 2 ) 4 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 7 -, -(CH 2 ) 4 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 8 -, -(CH 2 ) 5 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 1 -, -(CH 2 ) 5 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 2 -, -(CH 2 ) 5 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 3 -, -(CH 2 ) 5 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 4 -, -(CH 2 ) 5 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 5 -, -(CH 2 ) 5 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 6 -, -(CH 2 ) 5 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 7 -, -(CH 2 ) 5 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 8 -, -(CH 2 ) 6 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) i -, -(CH 2 ) 6 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 2 -, -(CH 2 ) 6 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 3 -, -(CH 2 ) 6 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 4 -, -(CH 2 ) 6 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 5 -, -(CH 2 ) 6 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 6 -, -(CH 2 ) 6 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 7 -, -(CH 2 ) 6 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 8 -, -(CH 2 ) 7 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) i -, -(CH 2 ) 7 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 2 -, -(CH 2 ) 7 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 3 -, -(CH 2 ) 7 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 4 -, -(CH 2 ) 7 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 8 -, -(CH 2 ) 8 -diazabicyclo[2.2.1]heptanylene-CH 2 -, -(CH 2 ) 8 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 2 -, -(CH 2 ) 8 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 3 -, -(CH 2 ) 8 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 4 -, -(CH 2 ) 8 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 5 -, -(CH 2 ) 8 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 6 -, -(CH 2 ) 8 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 7 -, -(CH 2 ) 8 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 8 -, -CH 2 -diazabicyclo[3.1.1]heptanylene-CH 2 -, -CH 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 2 -, -CH 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 3 -, -CH 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 4 -, -CH 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 5 -, -CH 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 6 -, -CH 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 7 -, -CH 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 8 -, -(CH 2 ) 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 1 -, -(CH 2 ) 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 2 -, -(CH 2 ) 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 3 -, -(CH 2 ) 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 4 -, -(CH 2 ) 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 5 -, -(CH 2 ) 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 6 -, -(CH 2 ) 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 7 -, -(CH 2 ) 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 8 -, -(CH 2 ) 3 -diazabicyclo[3.1.1]heptanylene-CH 2 -, -(CH 2 ) 3 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 2 -, -(CH 2 ) 3 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 3 -, -(CH 2 ) 3 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 4 -, -(CH 2 ) 3 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 5 -, -(CH 2 ) 3 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 6 -, -(CH 2 ) 3 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 7 -, -(CH 2 ) 3 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 8 -, -(CH 2 ) 4 -diazabicyclo[3.1.1]heptanylene-CH 2 -, -(CH 2 ) 4 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 2 -, -(CH 2 ) 4 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 3 -, -(CH 2 ) 4 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 4 -, -(CH 2 ) 4 -diazabicyclo[3. 1. 1]heptanylene-(CH 2 ) 5 -, -(CH 2 ) 4 -diazabicyclo[3.1. 1]heptanylene-(CH 2 ) 6 -, -(CH 2 ) 4 -diazabicyclo[3. 1. 1]heptanylene-(CH 2 ) 7 -, -(CH 2 ) 4 -diazabicyclo[3.1. 1]heptanylene-(CH 2 ) 8 -, -(CH 2 ) 5 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 1 -, -(CH 2 ) 5 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 2 -, -(CH 2 ) 5 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 3 -, -(CH 2 ) 5 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 4 -, -(CH 2 ) 5 -diazabicyclo[3. 1. 1]heptanylene-(CH 2 ) 5 -, -(CH 2 ) 5 -diazabicyclo[3.1. 1]heptanylene-(CH 2 ) 6 -, -(CH 2 ) 5 -diazabicyclo[3. 1. 1]heptanylene-(CH 2 ) 7 -, -(CH 2 ) 5 -diazabicyclo[3.1. 1]heptanylene-(CH 2 ) 8 -, -(CH 2 ) 6 -diazabicyclo[3. 1. 1]heptanylene-(CH 2 ) 1 -, -(CH 2 ) 6 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 2 -, -(CH 2 ) 6 -diazabicyclo[3. 1. 1]heptanylene-(CH 2 ) 3 -, -(CH 2 ) 6 -diazabicyclo[3.1. 1]heptanylene-(CH 2 ) 4 -, -(CH 2 ) 6 -diazabicyclo[3. 1. 1]heptanylene-(CH 2 ) 5 -, -(CH 2 ) 6 -diazabicyclo[3.1. 1]heptanylene-(CH 2 ) 6 -, -(CH 2 ) 6 -diazabicyclo[3. 1. 1]heptanylene-(CH 2 ) 7 -, -(CH 2 ) 6 -diazabicyclo[3.1. 1]heptanylene-(CH 2 ) 8 -, -(CH 2 ) 7 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 1 -, -(CH 2 ) 7 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 2 -, -(CH 2 ) 7 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 3 -, -(CH 2 ) 7 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 4 -, -(CH 2 ) 7 -diazabicyclo[3.1.1]heptanylene-(CH Z ) s -, -(CH 2 ) 8 -diazabicyclo[3.1.1]heptanylene-CH 2 -, -(CH 2 ) 8 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 2 -, -(CH 2 ) 8 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 3 -, -(CH 2 ) 8 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 4 -, -(CH 2 ) 8 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 5 -, -(CH 2 ) 8 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 6 -, -(CH 2 ) 8 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 7 -, -(CH 2 ) 8 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 8 -, -CH 2 -diazabicyclo[3.2.1]octylene-CH 2 -, -CH 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 2 -, -CH 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 3 -, -CH 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 4 -, -CH 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 5 -, -CH 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 6 -, -CH 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 7 -, -CH 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 8 -, -(CH 2 ) 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 1 -, -(CH 2 ) 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 2 -, -(CH 2 ) 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 3 -, -(CH 2 ) 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 4 -, -(CH 2 ) 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 5 -, -(CH 2 ) 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 6 -, -(CH 2 ) 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 7 -, -(CH 2 ) 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 8 -, -(CH 2 ) 3 -diazabicyclo[3.2.1]octylene-CH 2 -, -(CH 2 ) 3 -diazabicyclo[3.2.1]octylene-(CH 2 ) 2 -, -(CH 2 ) 3 -diazabicyclo[3.2.1]octylene-(CH 2 ) 3 -, -(CH 2 ) 3 -diazabicyclo[3.2.1]octylene-(CH 2 ) 4 -, -(CH 2 ) 3 -diazabicyclo[3.2.1]octylene-(CH 2 ) 5 -, -(CH 2 ) 3 -diazabicyclo[3.2.1]octylene-(CH 2 ) 6 -, -(CH 2 ) 3 -diazabicyclo[3.2.1]octylene-(CH 2 ) 7 -, -(CH 2 ) 3 -diazabicyclo[3.2.1]octylene-(CH 2 ) 8 -, -(CH 2 ) 4 -diazabicyclo[3.2.1]octylene-CH 2 -, -(CH 2 ) 4 -diazabicyclo[3.2.1]octylene-(CH 2 ) 2 -, -(CH 2 ) 4 -diazabicyclo[3.2.1]octylene-(CH 2 ) 3 -, -(CH 2 ) 4 -diazabicyclo[3.2.1]octylene-(CH 2 ) 4 -, -(CH 2 ) 4 -diazabicyclo[3.2.1]octylene-(CH 2 ) 5 -, -(CH 2 ) 4 -diazabicyclo[3.2.1]octylene-(CH 2 ) 6 -, -(CH 2 ) 4 -diazabicyclo[3.2.1]octylene-(CH 2 ) 7 -, -(CH 2 ) 4 -diazabicyclo[3.2.1]octylene-(CH 2 ) 8 -, -(CH 2 ) 5 -diazabicyclo[3.2.1]octylene-(CH 2 ) 1 -, -(CH 2 ) 5 -diazabicyclo[3.2.1]octylene-(CH 2 ) 2 -, -(CH 2 ) 5 -diazabicyclo[3.2.1]octylene-(CH 2 ) 3 -, -(CH 2 ) 5 -diazabicyclo[3.2.1]octylene-(CH 2 ) 4 -, -(CH 2 ) 5 -diazabicyclo[3.2.1]octylene-(CH 2 ) 5 -, -(CH 2 ) 5 -diazabicyclo[3.2.1]octylene-(CH 2 ) 6 -, -(CH 2 ) 5 -diazabicyclo[3.2.1]octylene-(CH 2 ) 7 -, -(CH 2 ) 5 -diazabicyclo[3.2.1]octylene-(CH 2 ) 8 -, -(CH 2 ) 6 -diazabicyclo[3.2.1]octylene-(CH 2 ) 1 -, -(CH 2 ) 6 -diazabicyclo[3.2.1]octylene-(CH 2 ) 2 -, -(CH 2 ) 6 -diazabicyclo[3.2.1]octylene-(CH 2 ) 3 -, -(CH 2 ) 6 -diazabicyclo[3.2.1]octylene-(CH 2 ) 4 -, -(CH 2 ) 6 -diazabicyclo[3.2.1]octylene-(CH 2 ) 5 -, -(CH 2 ) 6 -diazabicyclo[3.2.1]octylene-(CH 2 ) 6 -, -(CH 2 ) 6 -diazabicyclo[3.2.1]octylene-(CH 2 ) 7 -, -(CH 2 ) 6 -diazabicyclo[3.2.1]octylene-(CH 2 ) 8 -, -(CH 2 ) 7 -diazabicyclo[3.2.1]octylene-(CH 2 ) 1 -, -(CH 2 ) 7 -diazabicyclo[3.2.1]octylene-(CH 2 ) 2 -, -(CH 2 ) 7 -diazabicyclo[3.2.1]octylene-(CH 2 ) 3 -, -(CH 2 ) 7 -diazabicyclo[3.2.1]octylene-(CH 2 ) 4 -, -(CH 2 ) 7 -diazabicyclo[3.2.1]octylene-(CH 2 ) 8 -, -(CH 2 ) 8 -diazabicyclo[3.2. 1]octylene-CH 2 -, -(CH 2 ) 8 -diazabicyclo[3.2.1]octylene-(CH 2 ) 2 -, -(CH 2 ) 8 -diazabicyclo[3.2.1]octylene-(CH 2 ) 3 -, -(CH 2 ) 8 -diazabicyclo[3.2.1]octylene-(CH 2 ) 4 -, -(CH 2 ) 8 -diazabicyclo[3.2.1]octylene-(CH 2 ) 5 -, -(CH 2 ) 8 -diazabicyclo[3.2.1]octylene-(CH 2 ) 6 -, -(CH 2 ) 8 -diazabicyclo[3.2.1]octylene-(CH 2 ) 7 -, -(CH 2 ) 8 -diazabicyclo[3.2.1]octylene-(CH 2 ) 8 -, -CH 2 -diazabicyclo[2.2.2]octylene-CH 2 -, -CH 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 2 -, -CH 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 3 -, -CH 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 4 -, -CH 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 5 -, -CH 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 6 -, -CH 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 7 -, -CH 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 8 -, -(CH 2 ) 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 1 -, -(CH 2 ) 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 2 -, -(CH 2 ) 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 3 -, -(CH 2 ) 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 4 -, -(CH 2 ) 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 5 -, -(CH 2 ) 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 6 -, -(CH 2 ) 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 7 -, -(CH 2 ) 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 8 -, -(CH 2 ) 3 -diazabicyclo[2.2.2]octylene-CH 2 -, -(CH 2 ) 3 -diazabicyclo[2.2.2]octylene-(CH 2 ) 2 -, -(CH 2 ) 3 -diazabicyclo[2.2.2]octylene-(CH 2 ) 3 -, -(CH 2 ) 3 -diazabicyclo[2.2.2]octylene-(CH 2 ) 4 -, -(CH 2 ) 3 -diazabicyclo[2.2.2]octylene-(CH 2 ) 5 -, -(CH 2 ) 3 -diazabicyclo[2.2.2]octylene-(CH 2 ) 6 -, -(CH 2 ) 3 -diazabicyclo[2.2.2]octylene-(CH 2 ) 7 -, -(CH 2 ) 3 -diazabicyclo[2.2.2]octylene-(CH 2 ) 8 -, -(CH 2 ) 4 -diazabicyclo[2.2.2]octylene-CH 2 -, -(CH 2 ) 4 -diazabicyclo[2.2.2]octylene-(CH 2 ) 2 -, -(CH 2 ) 4 -diazabicyclo[2.2.2]octylene-(CH 2 ) 3 -, -(CH 2 ) 4 -diazabicyclo[2.2.2]octylene-(CH 2 ) 4 -, -(CH 2 ) 4 -diazabicyclo[2.2.2]octylene-(CH 2 ) 5 -, -(CH 2 ) 4 -diazabicyclo[2.2.2]octylene-(CH 2 ) 6 -, -(CH 2 ) 4 -diazabicyclo[2.2.2]octylene-(CH 2 ) 7 -, -(CH 2 ) 4 -diazabicyclo[2.2.2]octylene-(CH 2 ) 8 -, -(CH 2 ) 5 -diazabicyclo[2.2.2]octylene-(CH 2 ) 1 -, -(CH 2 ) 5 -diazabicyclo[2.2.2]octylene-(CH 2 ) 2 -, -(CH 2 ) 5 -diazabicyclo[2.2.2]octylene-(CH 2 ) 3 -, -(CH 2 ) 5 -diazabicyclo[2.2.2]octylene-(CH 2 ) 4 -, -(CH 2 ) 5 -diazabicyclo[2.2.2]octylene-(CH 2 ) 5 -, -(CH 2 ) 5 -diazabicyclo[2.2.2]octylene-(CH 2 ) 6 -, -(CH 2 ) 5 -diazabicyclo[2.2.2]octylene-(CH 2 ) 7 -, -(CH 2 ) 5 -diazabicyclo[2.2.2]octylene-(CH 2 ) 8 -, -(CH 2 ) 6 -diazabicyclo[2.2.2]octylene-(CH 2 ) 1 -, -(CH 2 ) 6 -diazabicyclo[2.2.2]octylene-(CH 2 ) 2 -, -(CH 2 ) 6 -diazabicyclo[2.2.2]octylene-(CH 2 ) 3 -, -(CH 2 ) 6 -diazabicyclo[2.2.2]octylene-(CH 2 ) 4 -, -(CH 2 ) 6 -diazabicyclo[2.2.2]octylene-(CH 2 ) 5 -, -(CH 2 ) 6 -diazabicyclo[2.2.2]octylene-(CH 2 ) 6 -, -(CH 2 ) 6 -diazabicyclo[2.2.2]octylene-(CH 2 ) 7 -, -(CH 2 ) 6 -diazabicyclo[2.2.2]octylene-(CH 2 ) 8 -, -(CH 2 ) 7 -diazabicyclo[2.2.2]octylene-(CH 2 ) 1 -, -(CH 2 ) 7 -diazabicyclo[2.2.2]octylene-(CH 2 ) 2 -, -(CH 2 ) 7 -diazabicyclo[2.2.2]octylene-(CH 2 ) 3 -, -(CH 2 ) 7 -diazabicyclo[2.2.2]octylene-(CH 2 ) 4 -, -(CH 2 ) 7 -diazabicyclo[2.2.2]octylene-(CH 2 ) 8 -, -(CH 2 ) 8 -diazabicyclo[2.2.2]octylene-CH 2 -, -(CH 2 ) 8 -diazabicyclo[2.2.2]octylene-(CH 2 ) 2 -, -(CH 2 ) 8 -diazabicyclo[2.2.2]octylene-(CH 2 ) 3 -, -(CH 2 ) 8 -diazabicyclo[2.2.2]octylene-(CH 2 ) 4 -, -(CH 2 ) 8 -diazabicyclo[2.2.2]octylene-(CH 2 ) 5 -, -(CH 2 ) 8 -diazabicyclo[2.2.2]octylene-(CH 2 ) 6 -, -(CH 2 ) 8 -diazabicyclo[2.2.2]octylene-(CH 2 ) 7 -, or -(CH 2 ) 8 -diazabicyclo[2.2.2]octylene-(CH 2 ) 8 -, wherein the propylene, the piperidinylene, the piperazinylene, the diazacycloheptanylene, the diazabicyclo[2.2.1]heptanylene, the diazabicyclo[3.1.1]heptanylene, the diazabicyclo[3.2.1]octylene, the diazabicyclo[2.2.2]octylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C 1-4 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH- or any combination thereof; and each R g11 independently represents H or C 1-3 alkyl.

[0043] In some embodiments of the compound of Formula (I-1), L 2 represents the structure of the following formula:

[0044] In some embodiments of the compound of Formula (I-1), R b1 represents: cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptanyl, 2-oxobicyclo[2.2.1]heptanyl or bicyclo[2.2.1]heptenyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C 1-4 alkyl, optionally substituted C 3-15 cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C 6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, or any combination thereof, and the C 3-15 cycloalkyl, the 4- to 15-membered heterocyclyl, the C 6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C 1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, or any combination thereof; azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octyl, 2,5-diazabicyclo[2.2.2]octyl, 3-azaspiro[5.5]undecyl or 7-azaspiro[3.5]nonyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C 1-4 alkyl, optionally substituted C 3-15 cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C 6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, or any combination thereof, and the C 3-15 cycloalkyl, the 4- to 15-membered heterocyclyl, the C 6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C 1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, or any combination thereof; phenyl or naphthyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C 1-4 alkyl, optionally substituted C 3-15 cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C 6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, or any combination thereof, and the C 3-15 cycloalkyl, the 4- to 15-membered heterocyclyl, the C 6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C 1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, or any combination thereof; or furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl and imidazo[2,1-b]thiazolyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C 1-4 alkyl, optionally substituted C 3-15 cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C 6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, or any combination thereof, and the C 3-15 cycloalkyl, the 4- to 15-membered heterocyclyl, the C 6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C 1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, or any combination thereof. In embodiments of the present disclosure, the number of substituents is not theoretically limited in any way or automatically limited by the size of the building units.

[0045] In some embodiments of the compound of Formula (I-1), R b1 represents: or

[0046] In some embodiments, the compound of Formula (I) is also of Formula (I-2): wherein R c1 , R c2 , R c3 , R c4 , R c5 , R c6 , R b , (R 1a ) n , R a , R 1a and n are as defined in the compound of Formula (I) above and the embodiments thereof; wherein R a represents the following formula:         R a1 -X 2 -L 1 -X 1 - , wherein X 1 represents N(R e1 ), O, S, alkynylene (e.g., C 2-6 alkynylene), alkenylene (e.g., C 2-6 alkenylene), optionally substituted cycloalkylene (e.g., optionally substituted C 3-20 cycloalkylene or optionally substituted C 3-15 cycloalkylene), optionally substituted heterocyclylene (e.g., optionally substituted 4- to 20-membered heterocyclylene or optionally substituted 4- to 15-membered heterocyclylene), optionally substituted arylene (e.g., optionally substituted C 6-10 arylene), or optionally substituted heteroarylene (e.g., optionally substituted 5- to 20-membered heteroarylene or optionally substituted 5- to 15-membered heteroarylene), wherein R e1 represents H or C 1-3 alkyl, or X 1 represents a bond; L 1 represents: optionally substituted linear or branched C 1-60 alkylene (e.g., C 1 -C 40 alkylene, C 1 -C 30 alkylene, C 1 -C 29 alkylene, C 1 -C 28 alkylene, C 1 -C 27 alkylene, C 1 -C 26 alkylene, C 1 -C 25 alkylene, C 1 -C 24 alkylene, C 1 -C 23 alkylene, C 1 -C 22 alkylene, C 1 -C 21 alkylene, C 1 -C 20 alkylene, C 1 -C 19 alkylene, C 1 -C 18 alkylene, C 1 -C 17 alkylene, C 1 -C 16 alkylene, C 1 -C 15 alkylene, C 1 -C 14 alkylene, C 1 -C 13 alkylene, C 1 -C 12 alkylene, C 1 -C 11 alkylene, C 1 -C 10 alkylene, C 1 -C 9 alkylene, C 1 -C 8 alkylene, C 1 -C 7 alkylene, C 1 -C 6 alkylene, C 1 -C 5 alkylene, C 1 -C 4 alkylene, C 1 -C 3 alkylene, or C 1 -C 2 alkylene), or optionally substituted linear or branched C 2-60 alkylene (e.g., C 2 -C 40 alkylene, C 2 -C 30 alkylene, C 2 -C 29 alkylene, C 2 -C 28 alkylene, C 2 -C 27 alkylene, C 2 -C 26 alkylene, C 2 -C 25 alkylene, C 2 -C 24 alkylene, C 2 -C 23 alkylene, C 2 -C 22 alkylene, C 2 -C 21 alkylene, C 2 -C 20 alkylene, C 2 -C 19 alkylene, C 2 -C 18 alkylene, C 2 -C 17 alkylene, C 2 -C 16 alkylene, C 2 -C 15 alkylene, C 2 -C 14 alkylene, C 2 -C 13 alkylene, C 2 -C 12 alkylene, C 2 -C 11 alkylene, C 2 -C 10 alkylene, C 2 -C 9 alkylene, C 2 -C 8 alkylene, C 2 -C 7 alkylene, C 2 -C 6 alkylene, C 2 -C 5 alkylene, C 2 -C 4 alkylene, C 2 -C 3 alkylene, or ethylene) with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R e2 and / or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R e3 and / or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R e2 and R e3 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1 pair) of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R e2 , R e3 , or a combination of R e2 and R e3 ; wherein each R e2 is independently selected from the group consisting of O, S, N(R e4 ), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O) 2 , S(O) 2 O, OS(O) 2 , S(O) 2 NH, or NHS(O) 2 , wherein R e4 represents H or C 1-3 alkyl, and in case that two or more groups R e2 are inserted into the backbone carbon chain of the linear or branched C 2-60 alkylene group, the two or more groups R e2 are not directly connected to each other; and wherein each R e3 is independently selected from the group consisting of optionally substituted cycloalkylene (e.g., optionally substituted C 3-20 cycloalkylene, or optionally substituted C 3-15 cycloalkylene), optionally substituted heterocyclylene (e.g., optionally substituted 4- to 20-membered heterocyclylene, or optionally substituted 5- to 15-membered heterocyclylene), optionally substituted arylene (e.g., optionally substituted C 6-10 arylene), optionally substituted heteroarylene (e.g., optionally substituted 5- to 20-membered heteroarylene, or optionally substituted 5- to 15-membered heteroarylene), alkenylene (e.g., C 2-6 alkenylene), alkynylene (e.g., C 2-6 alkynylene) or any combination thereof; X 2 represents C(O), S(O) or S(O) 2 , or X 2 represents a bond; R a1 represents the following formula: wherein R f1 represents:         -NCH 2 CH 2 N-; wherein symbol * indicates the point of attachment to X 2 , R g1 represents H or C 1-3 alkyl, ring A represents cycloalkylene (e.g., C 3-20 cycloalkylene, or C 3-15 cycloalkylene) or heterocyclylene (e.g., 4- to 20-membered heterocyclylene, or 5- to 15-membered heterocyclylene), (R g2 ) n1 indicates that ring A is optionally substituted with n1 R g2 , wherein n1 represents an integer of 0 to 8, and each R g2 , the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 alkoxy, halogenated C 1-6 alkyl, NH 2 -C 1-6 alkylene or any combination thereof; wherein symbol ** indicates the point of attachment to X 2 , R g3 represents H or C 1-3 alkyl, ring B represents cycloalkylene (e.g., C 3-20 cycloalkylene, or C 3-15 cycloalkylene) or heterocyclylene (e.g., 4- to 20-membered heterocyclylene, or 5- to 15-membered heterocyclylene), (R g4 ) n2 indicates that ring B is optionally substituted with n2 R g4 , wherein n2 represents an integer of 0 to 8, and each R g4 , the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 alkoxy, halogenated C 1-6 alkyl, NH 2 -C 1-6 alkylene or any combination thereof; or wherein ring C represents cycloalkylene (e.g., C 3-20 cycloalkylene, or C 3-15 cycloalkylene) or heterocyclylene (e.g., 4- to 20-membered heterocyclylene, or 5- to 15-membered heterocyclylene), (R g5 ) n3 indicates that ring C is optionally substituted with n3 R g5 , wherein n3 represents an integer of 0 to 8, and each R g5 , the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 alkoxy, halogenated C 1-6 alkyl, NH 2 -C 1-6 alkylene or any combination thereof; R f2 represents H, halogen, C 1-3 alkyl or halogenated C 1-3 alkyl; R f3 represents H, halogen, C 1-3 alkyl, halogenated C 1-3 alkyl, or wherein ring D represents cycloalkylene (e.g., C 3-20 cycloalkylene, or C 3-15 cycloalkylene), heterocyclylene (e.g., 4- to 20-membered heterocyclylene, or 5- to 15-membered heterocyclylene), arylene (e.g., C 6-10 arylene) or heteroarylene (e.g., 5-to 20-membered heteroarylene, or 5- to 15-membered heteroarylene), (R g6 ) n4 indicates that ring D is optionally substituted with n4 R g6 , wherein n4 represents an integer of 0 to 8, and each R g6 , the same or different from each other, is independently selected from the group consisting of optionally deuterated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 alkoxy, halogenated C 1-6 alkyl, NH 2 -C 1-6 alkylene or any combination thereof; R f4 represents wherein symbol *** indicates the point of attachment to R f5 , ring E represents cycloalkylene (e.g., C 3-20 cycloalkylene, or C 3-15 cycloalkylene), heterocyclylene (e.g., 4- to 20-membered heterocyclylene, or 5- to 15-membered heterocyclylene), arylene (e.g., C 6-10 arylene) or heteroarylene (e.g., 5- to 20-membered heteroarylene, or 5- to 15-membered heteroarylene), (R g7 ) n5 indicates that ring E is optionally substituted with n5 R g7 , wherein n5 represents an integer of 0 to 8, and each R g7 , the same or different from each other, is independently selected from the group consisting of optionally deuterated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 alkoxy, halogenated C 1-6 alkyl, NH 2 -C 1-6 alkylene or any combination thereof; and R f5 represents H, halogen, C 1-3 alkyl, halogenated C 1-3 alkyl, wherein ring F represents cycloalkyl (e.g., C 3-20 cycloalkyl, or C 3-15 cycloalkyl), heterocyclyl (e.g., 4- to 20-membered heterocyclyl, or 5- to 15-membered heterocyclyl), aryl (e.g., C 6-10 aryl) or heteroaryl (e.g., 5- to 20-membered heteroaryl, or 5- to 15-membered heteroaryl), (R g8 ) n6 indicates that ring F is optionally substituted with n6 R g8 , wherein n6 represents an integer of 0 to 8, and each R g8 , the same or different from each other, is independently selected from the group consisting of optionally deuterated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 alkoxy, halogenated C 1-6 alkyl, NH 2 -C 1-6 alkylene or any combination thereof; and R b represents C 1-60 alkyl (e.g., C 1 -C 30 alkyl, C 1 -C 29 alkyl, C 1 -C 28 alkyl, C 1 -C 27 alkyl, C 1 -C 26 alkyl, C 1 -C 25 alkyl, C 1 -C 24 alkyl, C 1 -C 23 alkyl, C 1 -C 22 alkyl, C 1 -C 21 alkyl, C 1 -C 20 alkyl, C 1 -C 19 alkyl, C 1 -C 18 alkyl, C 1 -C 17 alkyl, C 1 -C 16 alkyl, C 1 -C 15 alkyl, C 1 -C 14 alkyl, C 1 -C 13 alkyl, C 1 -C 12 alkyl, C 1 -C 11 alkyl, C 1 -C 10 alkyl, C 1 -C 9 alkyl, C 1 -Cs alkyl, C 1 -C 7 alkyl, C 1 -C 6 alkyl, C 1 -C 5 alkyl, C 1 -C 4 alkyl, C 1 -C 3 alkyl, or C 1 -C 2 alkyl) optionally substituted with D or halogen, or R b represents the following formula:         R b1 -X 4 -L 2 -, wherein L 2 represents: optionally substituted linear or branched C 2-60 alkylene (e.g., C 2 -C 40 alkylene, C 2 -C 30 alkylene, C 2 -C 29 alkylene, C 2 -C 28 alkylene, C 2 -C 27 alkylene, C 2 -C 26 alkylene, C 2 -C 25 alkylene, C 2 -C 24 alkylene, C 2 -C 23 alkylene, C 2 -C 22 alkylene, C 2 -C 21 alkylene, C 2 -C 20 alkylene, C 2 -C 19 alkylene, C 2 -C 18 alkylene, C 2 -C 17 alkylene, C 2 -C 16 alkylene, C 2 -C 15 alkylene, C 2 -C 14 alkylene, C 2 -C 13 alkylene, C 2 -C 12 alkylene, C 2 -C 11 alkylene, C 2 -C 10 alkylene, C 2 -C 9 alkylene, C 2 -C 8 alkylene, C 2 -C 7 alkylene, C 2 -C 6 alkylene, C 2 -C 5 alkylene, C 2 -C 4 alkylene, C 2 -C 3 alkylene, or ethylene), or optionally substituted linear or branched C 2-60 alkylene (e.g., C 2 -C 40 alkylene, C 2 -C 30 alkylene, C 2 -C 29 alkylene, C 2 -C 28 alkylene, C 2 -C 27 alkylene, C 2 -C 26 alkylene, C 2 -C 25 alkylene, C 2 -C 24 alkylene, C 2 -C 23 alkylene, C 2 -C 22 alkylene, C 2 -C 21 alkylene, C 2 -C 20 alkylene, C 2 -C 19 alkylene, C 2 -C 18 alkylene, C 2 -C 17 alkylene, C 2 -C 16 alkylene, C 2 -C 15 alkylene, C 2 -C 14 alkylene, C 2 -C 13 alkylene, C 2 -C 12 alkylene, C 2 -C 11 alkylene, C 2 -C 10 alkylene, C 2 -C 9 alkylene, C 2 -C 8 alkylene, C 2 -C 7 alkylene, C 2 -C 6 alkylene, C 2 -C 5 alkylene, C 2 -C 4 alkylene, C 2 -C 3 alkylene, or ethylene) with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R 12 and / or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R 13 and / or any combination of one or more(e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R 12 and R 13 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1 pair) of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R 12 , R 13 , or a combination of R 12 and R 13 ; wherein each R 12 is independently selected from the group consisting of O, S, N(R 14 ), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O) 2 , S(O) 2 O, OS(O) 2 , S(O) 2 NH or NHS(O) 2 , wherein R 14 independently represents H or C 1-3 alkyl, and in case that two or more groups R 12 are inserted into the backbone carbon chain of the linear or branched C 2-60 alkylene group, the two or more groups R 12 are not directly connected to each other; and wherein each R 13 is independently selected from the group consisting of cycloalkylene (e.g., C 3-20 cycloalkylene, or C 3-15 cycloalkylene), heterocyclylene (e.g., 4- to 20-membered heterocyclylene, or 4- to 15-membered heterocyclylene), arylene (e.g., C 6-10 arylene), heteroarylene (e.g., 5- to 20-membered heteroarylene, or 5- to 15-membered heteroarylene), alkenylene (e.g., C 2-6 alkenylene), alkynylene (e.g., C 2-6 alkynylene) or any combination thereof, wherein the cycloalkylene, the heterocyclylene, arylene and the heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of D, optionally deuterated C 1-4 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, cyano or any combination thereof; X 4 represents N(R 15 ), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(=S), S, S(O), S(O) 2 , S(O) 2 NH, NHS(O) 2 , S(O) 2 O, OS(O) 2 , optionally substituted cycloalkylene (e.g., optionally substituted C 3-20 cycloalkylene, or optionally substituted C 3-15 cycloalkylene), optionally substituted arylene (e.g., optionally substituted C 6-20 arylene, or optionally substituted C 6-10 arylene), optionally substituted heterocyclylene (e.g., optionally substituted 4- to 20-membered heterocyclylene, or optionally substituted 4- to 15-membered heterocyclylene), optionally substituted heteroarylene (e.g., optionally substituted 5- to 20-membered heteroarylene, or optionally substituted 5- to 15-membered heteroarylene), triazolylene-NH-, or -NH-triazolylene, wherein R 15 represents H or C 1-3 alkyl, or X 4 represents a bond; and R b1 represents optionally substituted cycloalkyl (e.g., optionally substituted C 3-20 cycloalkyl, or optionally substituted C 3-15 cycloalkyl), optionally substituted aryl (e.g., optionally substituted C 6-20 aryl, or optionally substituted C 6-10 aryl), optionally substituted heterocyclyl (e.g., optionally substituted 4- to 20-membered heterocyclyl, or optionally substituted 4- to 15-membered heterocyclyl) or optionally substituted heteroaryl (e.g., optionally substituted 5- to 20-membered heteroaryl, or optionally substituted 5- to 15-membered heteroaryl).

[0047] In some embodiments of the compound of Formula (I-2), R a represents the following formula:         R a1 -X 2 -L 1 -X 1 - , wherein X 1 represents N(R e1 ), O, S, C 2-6 alkynylene, C 2-6 alkenylene, optionally substituted C 3-20 cycloalkylene (e.g., optionally substituted C 3-15 cycloalkylene), optionally substituted 4- to 20-membered heterocyclylene (e.g., optionally substituted 4- to 15-membered heterocyclylene), optionally substituted C 6-15 arylene (e.g., optionally substituted C 6-10 arylene), or optionally substituted 5- to 20-membered heteroarylene (e.g., optionally substituted 5- to 15-membered heteroarylene), wherein R e1 represents H or C 1-3 alkyl, or X 1 represents a bond; L 1 represents: optionally substituted linear or branched C 1-60 alkylene (e.g., C 1 -C 40 alkylene, C 1 -C 30 alkylene, C 1 -C 29 alkylene, C 1 -C 28 alkylene, C 1 -C 27 alkylene, C 1 -C 26 alkylene, C 1 -C 25 alkylene, C 1 -C 24 alkylene, C 1 -C 23 alkylene, C 1 -C 22 alkylene, C 1 -C 21 alkylene, C 1 -C 20 alkylene, C 1 -C 19 alkylene, C 1 -C 18 alkylene, C 1 -C 17 alkylene, C 1 -C 16 alkylene, C 1 -C 15 alkylene, C 1 -C 14 alkylene, C 1 -C 13 alkylene, C 1 -C 12 alkylene, C 1 -C 11 alkylene, C 1 -C 10 alkylene, C 1 -C 9 alkylene, C 1 -C 8 alkylene, C 1 -C 7 alkylene, C 1 -C 6 alkylene, C 1 -C 5 alkylene, C 1 -C 4 alkylene, C 1 -C 3 alkylene, or C 1 -C 2 alkylene), or optionally substituted linear or branched C 2-60 alkylene (e.g., C 2 -C 40 alkylene, C 2 -C 30 alkylene, C 2 -C 29 alkylene, C 2 -C 28 alkylene, C 2 -C 27 alkylene, C 2 -C 26 alkylene, C 2 -C 25 alkylene, C 2 -C 24 alkylene, C 2 -C 23 alkylene, C 2 -C 22 alkylene, C 2 -C 21 alkylene, C 2 -C 20 alkylene, C 2 -C 19 alkylene, C 2 -C 18 alkylene, C 2 -C 17 alkylene, C 2 -C 16 alkylene, C 2 -C 15 alkylene, C 2 -C 14 alkylene, C 2 -C 13 alkylene, C 2 -C 12 alkylene, C 2 -C 11 alkylene, C 2 -C 10 alkylene, C 2 -C 9 alkylene, C 2 -C 8 alkylene, C 2 -C 7 alkylene, C 2 -C 6 alkylene, C 2 -C 5 alkylene, C 2 -C 4 alkylene, C 2 -C 3 alkylene, or ethylene) with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R e2 and / or one or more(e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R e3 and / or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R e2 and R e3 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1 pair) of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R e2 , R e3 , or a combination of R e2 and R e3 ; wherein each R e2 is independently selected from the group consisting of O, S, N(R e4 ), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O) 2 , S(O) 2 O, OS(O) 2 , S(O) 2 NH, or NHS(O) 2 , wherein R e4 represents H or C 1-3 alkyl, and in case that two or more groups R e2 are inserted into the backbone carbon chain of the linear or branched C 2-60 alkylene group, the two or more groups R e2 are not directly connected to each other; and wherein each R e3 is independently selected from the group consisting of optionally substituted C 3-15 cycloalkylene, optionally substituted 4- to 15-membered heterocyclylene, optionally substituted C 6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C 2-6 alkenylene, C 2-6 alkynylene or any combination thereof, wherein the linear or branched C 1-60 alkylene and the linear or branched C 2-60 alkylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C 1-6 alkyl (e.g., optionally deuterated C 1-4 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C 3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C 1-6 alkoxy (e.g., C 1-3 alkoxy, such as methoxy, ethoxy, or propoxy), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), or any combination thereof; X 2 represents C(O) or S(O) 2 , or X 2 represents a bond; R a1 represents the following formula: wherein R f1 represents:         -NCH 2 CH 2 N-; wherein symbol * indicates the point of attachment to X 2 , R g1 represents H or C 1-3 alkyl, ring A represents C 3-20 cycloalkylene or 4- to 20-membered heterocyclylene, (R g2 ) n1 indicates that ring A is optionally substituted with n1 R g2 , wherein n1 represents an integer of 0 to 8, and each R g2 , the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C 1-6 alkyl (e.g., optionally deuterated C 1-4 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C 3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 alkoxy (e.g., C 1-3 alkoxy, such as methoxy, ethoxy, or propoxy), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), NH 2 -C 1-6 alkylene (e.g., NH 2 -C 1-4 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - and NH 2 CH 2 CH 2 CH 2 -) or any combination thereof; wherein symbol ** indicates the point of attachment to X 2 , R g3 represents H or C 1-3 alkyl, ring B represents C 3-20 cycloalkylene or 4- to 20-membered heterocyclylene, (R g4 ) n2 indicates that ring B is optionally substituted with n2 R g4 , wherein n2 represents an integer of 0 to 8, and each R g4 , the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C 1-6 alkyl (e.g., optionally deuterated C 1-4 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C 3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 alkoxy (e.g., C 1-3 alkoxy, such as methoxy, ethoxy, or propoxy), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), NH 2 -C 1-6 alkylene (e.g., NH 2 -C 1-4 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - and NH 2 CH 2 CH 2 CH 2 -) or any combination thereof; or wherein ring C represents C 3-20 cycloalkylene or 4- to 20-membered heterocyclylene, (R g5 ) n3 indicates that ring C is optionally substituted with n3 R g5 , wherein n3 represents an integer of 0 to 8, and each R g5 , the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C 1-6 alkyl (e.g., optionally deuterated C 1-4 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C 3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 alkoxy (e.g., C 1-3 alkoxy, such as methoxy, ethoxy, or propoxy), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), NH 2 -C 1-6 alkylene (e.g., NH 2 -C 1-4 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - and NH 2 CH 2 CH 2 CH 2 -) or any combination thereof; R 12 represents H, halogen, C 1-3 alkyl or halogenated C 1-3 alkyl (e.g., F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -); R f3 represents H, halogen, C 1-3 alkyl, halogenated C 1-3 alkyl (e.g., F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), wherein ring D represents C 3-20 cycloalkylene, 4- to 20-membered heterocyclylene, C 6-15 arylene or 5- to 20-membered heteroarylene, (R g6 ) n4 indicates that ring D is optionally substituted with n4 R g6 , wherein n4 represents an integer of 0 to 8, and each R g6 , the same or different from each other, is independently selected from the group consisting of optionally deuterated C 1-6 alkyl (e.g., optionally deuterated C 1-4 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C 3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 alkoxy (e.g., C 1-3 alkoxy, such as methoxy, ethoxy, or propoxy), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), NH 2 -C 1-6 alkylene (e.g., NH 2 -C 1-4 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - and NH 2 CH 2 CH 2 CH 2 -) or any combination thereof; R f4 represents wherein symbol *** indicates the point of attachment to R f5 , ring E represents C 3-20 cycloalkylene, 4- to 20-membered heterocyclylene, C 6-15 arylene or 5- to 20-membered heteroarylene, (R g7 ) n5 indicates that ring E is optionally substituted with n5 R g7 , wherein n5 represents an integer of 0 to 8, and each R g7 , the same or different from each other, is independently selected from the group consisting of optionally deuterated C 1-6 alkyl (e.g., optionally deuterated C 1-4 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C 3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 alkoxy (e.g., C 1-3 alkoxy, such as methoxy, ethoxy, or propoxy), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), NH 2 -C 1-6 alkylene (e.g., NH 2 -C 1-4 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - and NH 2 CH 2 CH 2 CH 2 -) or any combination thereof; and R f5 represents H, halogen, C 1-3 alkyl, halogenated C 1-3 alkyl, or wherein ring F represents C 3-20 cycloalkyl, 4- to 20-membered heterocyclyl, C 6-15 aryl or 5- to 20-membered heteroaryl, (R g8 ) n6 indicates that ring F is optionally substituted with n6 R g8 , wherein n6 represents an integer of 0 to 8, and each R g8 , the same or different from each other, is independently selected from the group consisting of optionally deuterated C 1-6 alkyl (e.g., optionally deuterated C 1-4 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C 3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 alkoxy (e.g., C 1-3 alkoxy, such as methoxy, ethoxy, or propoxy), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), NH 2 -C 1-6 alkylene (e.g., NH 2 -C 1-4 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - and NH 2 CH 2 CH 2 CH 2 -) or any combination thereof;

[0048] In some embodiments of the compound of Formula (I-2), X 1 represents a bond.

[0049] In some embodiments of the compound of Formula (I-2), X 1 represents: N(R e1 ), O, S, C 2-6 alkynylene, C 2-6 alkenylene, optionally substituted C 3-20 cycloalkylene, optionally substituted 4- to 20-membered heterocyclylene, optionally substituted C 6-15 arylene, or optionally substituted 5- to 20-membered heteroarylene, wherein R e1 represents H or C 1-3 alkyl, wherein the C 3-20 cycloalkylene, the 4-to 20-membered heterocyclylene, the C 6-15 arylene, and the 5- to 20-membered heteroarylene are each independently optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C 1-4 alkyl (e.g., optionally deuterated C 1-3 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), hydroxy, amino, mercapto, halogen, cyano, C 1-4 alkoxy (e.g., C 1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C 1-4 alkyl-NH- (e.g., C 1-3 alkyl-NH-, such as CH 3 NH-, CH 3 CH 2 NH- or CH 3 CH 2 CH 2 NH-), halogenated C 1-4 alkyl (e.g., halogenated C 1-3 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), NH 2 -C 1-4 alkylene (e.g., NH 2 -C 1-3 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - and NH 2 CH 2 CH 2 CH 2 -), C 1-4 alkyl-NHC(O)- (e.g., C 1-3 alkyl-NHC(O)-, such as CH 3 -NHC(O)-, CH 3 CH 2 -NHC(O)-, and CH 3 CH 2 CH 2 -NHC(O)-), C 1-4 alkyl-C(O)NH- (e.g., C 1-3 alkyl-C(O)NH-, such as CH 3 -C(O)NH-, CH 3 CH 2 -C(O)NH-, and CH 3 CH 2 CH 2 -C(O)NH-), or any combination thereof.

[0050] In some embodiments of the compound of Formula (I-2), X 1 represents N(R e1 ), O, S, C 2-6 alkynylene or C 2-6 alkenylene, wherein R e1 represents H or C 1-3 alkyl.

[0051] In some embodiments of the compound of Formula (I-2), X 1 represents: cyclopropylene, cyclobutylene, cyclopentylene, cyclopentenylene, cyclohexylene, cyclohexenylene, cycloheptylene, cyclooctylene, decalinylene, octahydropentalenylene, octahydro-1H-indenylene, spiro[3.3]heptylene, spiro[2.5]octylene, spiro[3.5]nonylene, spiro[4.4]nonylene, spiro[4.5]decylene, spiro[5.5]undecylene, p-menthanylene, m-menthanylene, quinuclidinylene, adamantanylene, noradamantanylene, bornylene, bicyclo[2.2.1]heptanylene, 2-oxobicyclo[2.2.1]heptanylene or bicyclo[2.2.1]heptenylene, with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C 1-4 alkyl, halogenated C 1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C 1-4 alkoxy, C 1-4 alkyl-NH-, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, or any combination thereof; phenylene or naphthylene, wherein the phenylene or naphthylene is optionally substituted with one or more (e.g., 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C 1-4 alkyl, halogenated C 1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C 1-4 alkoxy, C 1-4 alkyl-NH-, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, or any combination thereof; azetidinylene, oxetanylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, tetrahydrofuranylene, tetrahydropyranylene, tetrahydrothienylene, tetrahydrothiopyranylene, oxazolidinylene, thiazolidinylene, piperidinylene, piperazinylene, morpholinylene, thiomorpholinylene, dioxacyclohexylene, azacycloheptanylene, azacyclooctylene, diazacycloheptanylene, diazacyclooctylene, 3-azabicyclo[3.1.0]hexylene, 6-azabicyclo[3.1.1]heptanylene, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octylene, 3,8-diazabicyclo[3.2.1]octylene, 2,5-diazabicyclo[2.2.2]octylene, 3-azaspiro[5.5]undecylene or 7-azaspiro[3.5]nonylene, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C 1-4 alkyl, halogenated C 1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C 1-4 alkoxy, C 1-4 alkyl-NH-, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, or any combination thereof; or furanylene, oxazolylene, isoxazolylene, oxadiazolylene, thienylene, thiazolylene, isothiazolylene, thiadiazolylene, pyrrolylene, imidazolylene, pyrazolylene, triazolylene, pyridylene, pyrimidinylene, pyridazinylene, pyrazinylene, indolylene, isoindolylene, benzofuranylene, isobenzofuranylene, benzothienylene, indazolylene, benzimidazolylene, benzoxazolylene, benzisoxazolylene, benzothiazolylene, benzisothiazolylene, benzotriazolylene, benzo[2,1,3]oxadiazolylene, benzo[2,1,3]thiadiazolylene, benzo[1,2,3]thiadiazolylene, quinolinylene, isoquinolinylene, naphthyridinylene, cinnolinylene, quinazolinylene, quinoxalinylene, phthalazinylene, pyrazolo[1,5-a]pyridylene, pyrazolo[1,5-a]pyrimidinylene, imidazo[1,2-a]pyridylene, 1H-pyrrolo[3,2-b]pyridylene, 1H-pyrrolo[2,3-b]pyridylene, 4H-fluoro[3,2-b]pyrrolylene, pyrrolo[2,1-b]thiazolylene or imidazo[2,1-b]thiazolylene, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C 1-4 alkyl, halogenated C 1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C 1-4 alkoxy, C 1-4 alkyl-NH-, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH-, or any combination thereof. In embodiments of the present disclosure, the number of substituents is not theoretically limited in any way or automatically limited by the size of the building units.

[0052] In some embodiments of the compound of Formula (I-2), X 1 represents NH, N(CH 3 ), O, S, ethynylene or vinylene.

[0053] In some embodiments of the compound of Formula (I-2), X 1 represents: wherein symbol # indicates the point of attachment to L 1 .

[0054] In some embodiments of the compound of Formula (I-2), R a1 represents the following formula: wherein R f1 represents:         -NCH 2 CH 2 N-; wherein symbol * indicates the point of attachment to X 2 , R g1 represents H or C 1-3 alkyl, and ring A represents: cyclopropylene, cyclobutylene, cyclopentylene, cyclopentenylene, cyclohexylene, cyclohexenylene, cycloheptylene, cyclooctylene, decalinylene, octahydropentalenylene, octahydro-1H-indenylene, spiro[3.3]heptylene, spiro[2.5]octylene, spiro[3.5]nonylene, spiro[4.4]nonylene, spiro[4.5]decylene, spiro[5.5]undecylene, p-menthanylene, m-menthanylene, quinuclidinylene, adamantanylene, noradamantanylene, bornylene, bicyclo[2.2.1]heptanylene, 2-oxobicyclo[2.2.1]heptanylene, bicyclo[2.2.1]heptenylene, azetidinylene, oxetanylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, tetrahydrofuranylene, tetrahydropyranylene, tetrahydrothienylene, tetrahydrothiopyranylene, oxazolidinylene, thiazolidinylene, piperidinylene, piperazinylene, morpholinylene, thiomorpholinylene, dioxacyclohexylene, azacycloheptanylene, azacyclooctylene, diazacycloheptanylene, diazacyclooctylene, 3-azabicyclo[3.1.0]hexylene, 6-azabicyclo[3.1.1]heptanylene, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octylene, 3,8-diazabicyclo[3.2.1]octylene, 2,5-diazabicyclo[2.2.2]octylene, 3-azaspiro[5.5]undecylene or 7-azaspiro[3.5]nonylene, and (R g2 ) n1 indicates that ring A is optionally substituted with n1 R g2 , wherein n1 represents an integer of 0 to 8, and each R g2 , the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 alkoxy, halogenated C 1-6 alkyl, NH 2 -C 1-6 alkylene or any combination thereof; wherein symbol ** indicates the point of attachment to X 2 , R g3 represents H or C 1-3 alkyl, and ring B represents: cyclopropylene, cyclobutylene, cyclopentylene, cyclopentenylene, cyclohexylene, cyclohexenylene, cycloheptylene, cyclooctylene, decalinylene, octahydropentalenylene, octahydro-1H-indenylene, spiro[3.3]heptylene, spiro[2.5]octylene, spiro[3.5]nonylene, spiro[4.4]nonylene, spiro[4.5]decylene, spiro[5.5]undecylene, p-menthanylene, m-menthanylene, quinuclidinylene, adamantanylene, noradamantanylene, bornylene, bicyclo[2.2.1]heptanylene, 2-oxobicyclo[2.2.1]heptanylene, bicyclo[2.2.1]heptenylene, azetidinylene, oxetanylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, tetrahydrofuranylene, tetrahydropyranylene, tetrahydrothienylene, tetrahydrothiopyranylene, oxazolidinylene, thiazolidinylene, piperidinylene, piperazinylene, morpholinylene, thiomorpholinylene, dioxacyclohexylene, azacycloheptanylene, azacyclooctylene, diazacycloheptanylene, diazacyclooctylene, 3-azabicyclo[3.1.0]hexylene, 6-azabicyclo[3.1.1]heptanylene, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octylene, 3,8-diazabicyclo[3.2.1]octylene, 2,5-diazabicyclo[2.2.2]octylene, 3-azaspiro[5.5]undecylene or 7-azaspiro[3.5]nonylene, and (R g4 ) n2 indicates that ring B is optionally substituted with n2 R g4 , wherein n2 represents an integer of 0 to 8, and each R g4 , the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 alkoxy, halogenated C 1-6 alkyl, NH 2 -C 1-6 alkylene or any combination thereof; or wherein ring C represents: cyclopropylene, cyclobutylene, cyclopentylene, cyclopentenylene, cyclohexylene, cyclohexenylene, cycloheptylene, cyclooctylene, decalinylene, octahydropentalenylene, octahydro-1H-indenylene, spiro[3.3]heptylene, spiro[2.5]octylene, spiro[3.5]nonylene, spiro[4.4]nonylene, spiro[4.5]decylene, spiro[5.5]undecylene, p-menthanylene, m-menthanylene, quinuclidinylene, adamantanylene, noradamantanylene, bornylene, bicyclo[2.2.1]heptanylene, 2-oxobicyclo[2.2.1]heptanylene, bicyclo[2.2.1]heptenylene, azetidinylene, oxetanylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, tetrahydrofuranylene, tetrahydropyranylene, tetrahydrothienylene, tetrahydrothiopyranylene, oxazolidinylene, thiazolidinylene, piperidinylene, piperazinylene, morpholinylene, thiomorpholinylene, dioxacyclohexylene, azacycloheptanylene, azacyclooctylene, diazacycloheptanylene, diazacyclooctylene, 3-azabicyclo[3.1.0]hexylene, 6-azabicyclo[3.1.1]heptanylene, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octylene, 3,8-diazabicyclo[3.2.1]octylene, 2,5-diazabicyclo[2.2.2]octylene, 3-azaspiro[5.5]undecylene or 7-azaspiro[3.5]nonylene, and (R g5 ) n3 indicates that ring C is optionally substituted with n3 R g5 , n3 represents an integer of 0 to 8, and each R g5 , the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 alkoxy, halogenated C 1-6 alkyl, NH 2 -C 1-6 alkylene or any combination thereof; R f2 represents H, halogen, C 1-3 alkyl or halogenated C 1-3 alkyl; R f3 represents H, halogen, C 1-3 alkyl, halogenated C 1-3 alkyl, wherein ring D represents: cyclopropylene, cyclobutylene, cyclopentylene, cyclopentenylene, cyclohexylene, cyclohexenylene, cycloheptylene, cyclooctylene, decalinylene, octahydropentalenylene, octahydro-1H-indenylene, spiro[3.3]heptylene, spiro[2.5]octylene, spiro[3.5]nonylene, spiro[4.4]nonylene, spiro[4.5]decylene, spiro[5.5]undecylene, p-menthanylene, m-menthanylene, quinuclidinylene, adamantanylene, noradamantanylene, bornylene, bicyclo[2.2.1]heptanylene, 2-oxobicyclo[2.2.1]heptanylene, bicyclo[2.2.1]heptenylene, azetidinylene, oxetanylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, tetrahydrofuranylene, tetrahydropyranylene, tetrahydrothienylene, tetrahydrothiopyranylene, oxazolidinylene, thiazolidinylene, piperidinylene, piperazinylene, morpholinylene, thiomorpholinylene, dioxacyclohexylene, azacycloheptanylene, azacyclooctylene, diazacycloheptanylene, diazacyclooctylene, 3-azabicyclo[3.1.0]hexylene, 6-azabicyclo[3.1.1]heptanylene, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octylene, 3,8-diazabicyclo[3.2.1]octylene, 2,5-diazabicyclo[2.2.2]octylene, 3-azaspiro[5.5]undecylene, 7-azaspiro[3.5]nonylene, phenylene, naphthylene, furanylene, oxazolylene, isoxazolylene, oxadiazolylene, thienylene, thiazolylene, isothiazolylene, thiadiazolylene, pyrrolylene, imidazolylene, pyrazolylene, triazolylene, pyridylene, pyrimidinylene, pyridazinylene, pyrazinylene, indolylene, isoindolylene, benzofuranylene, isobenzofuranylene, benzothienylene, indazolylene, benzimidazolylene, benzoxazolylene, benzisoxazolylene, benzothiazolylene, benzisothiazolylene, benzotriazolylene, benzo[2,1,3]oxadiazolylene, benzo[2,1,3]thiadiazolylene, benzo[1,2,3]thiadiazolylene, quinolinylene, isoquinolinylene, naphthyridinylene, cinnolinylene, quinazolinylene, quinoxalinylene, phthalazinylene, pyrazolo[1,5-a]pyridylene, pyrazolo[1,5-a]pyrimidinylene, imidazo[1,2-a]pyridylene, 1H-pyrrolo[3,2-b]pyridylene, 1H-pyrrolo[2,3-b]pyridylene, 4H-fluoro[3,2-b]pyrrolylene, pyrrolo[2,1-b]thiazolylene or imidazo[2,1-b]thiazolylene, and (R g6 ) n4 indicates that ring D is optionally substituted with n4 R g6 , wherein n4 represents an integer of 0 to 8, and each R g6 , the same or different from each other, is independently selected from the group consisting of optionally deuterated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 alkoxy, halogenated C 1-6 alkyl, NH 2 -C 1-6 alkylene or any combination thereof; R f4 represents wherein symbol *** indicates the point of attachment to R f5 , and ring E represents: cyclopropylene, cyclobutylene, cyclopentylene, cyclopentenylene, cyclohexylene, cyclohexenylene, cycloheptylene, cyclooctylene, decalinylene, octahydropentalenylene, octahydro-1H-indenylene, spiro[3.3]heptylene, spiro[2.5]octylene, spiro[3.5]nonylene, spiro[4.4]nonylene, spiro[4.5]decylene, spiro[5.5]undecylene, p-menthanylene, m-menthanylene, quinuclidinylene, adamantanylene, noradamantanylene, bornylene, bicyclo[2.2.1]heptanylene, 2-oxobicyclo[2.2.1]heptanylene, bicyclo[2.2.1]heptenylene, azetidinylene, oxetanylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, tetrahydrofuranylene, tetrahydropyranylene, tetrahydrothienylene, tetrahydrothiopyranylene, oxazolidinylene, thiazolidinylene, piperidinylene, piperazinylene, morpholinylene, thiomorpholinylene, dioxacyclohexylene, azacycloheptanylene, azacyclooctylene, diazacycloheptanylene, diazacyclooctylene, 3-azabicyclo[3.1.0]hexylene, 6-azabicyclo[3.1.1]heptanylene, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octylene, 3,8-diazabicyclo[3.2.1]octylene, 2,5-diazabicyclo[2.2.2]octylene, 3-azaspiro[5.5]undecylene, 7-azaspiro[3.5]nonylene, phenylene, naphthylene, furanylene, oxazolylene, isoxazolylene, oxadiazolylene, thienylene, thiazolylene, isothiazolylene, thiadiazolylene, pyrrolylene, imidazolylene, pyrazolylene, triazolylene, pyridylene, pyrimidinylene, pyridazinylene, pyrazinylene, indolylene, isoindolylene, benzofuranylene, isobenzofuranylene, benzothienylene, indazolylene, benzimidazolylene, benzoxazolylene, benzisoxazolylene, benzothiazolylene, benzisothiazolylene, benzotriazolylene, benzo[2,1,3]oxadiazolylene, benzo[2,1,3]thiadiazolylene, benzo[1,2,3]thiadiazolylene, quinolinylene, isoquinolinylene, naphthyridinylene, cinnolinylene, quinazolinylene, quinoxalinylene, phthalazinylene, pyrazolo[1,5-a]pyridylene, pyrazolo[1,5-a]pyrimidinylene, imidazo[1,2-a]pyridylene, 1H-pyrrolo[3,2-b]pyridylene, 1H-pyrrolo[2,3-b]pyridylene, 4H-fluoro[3,2-b]pyrrolylene, pyrrolo[2,1-b]thiazolylene or imidazo[2,1-b]thiazolylene, and (R g7 ) n5 indicates that ring E is optionally substituted with n5 R g7 , wherein n5 represents an integer of 0 to 8, and each R g7 , the same or different from each other, is independently selected from the group consisting of optionally deuterated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 alkoxy, halogenated C 1-6 alkyl, NH 2 -C 1-6 alkylene or any combination thereof; and R f5 represents H, halogen, C 1-3 alkyl, halogenated C 1-3 alkyl, wherein ring F represents: cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptanyl, 2-oxobicyclo[2.2.1]heptanyl, bicyclo[2.2.1]heptenyl, azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octyl, 2,5-diazabicyclo[2.2.2]octyl, 3-azaspiro[5.5]undecyl, 7-azaspiro[3.5]nonyl, phenyl, naphthyl, furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl or imidazo[2,1-b]thiazolyl, and (R g8 ) n6 indicates that ring F is optionally substituted with n6 R g8 , wherein n6 represents an integer of 0 to 8, and each R g8 , the same or different from each other, is independently selected from the group consisting of optionally deuterated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 alkoxy, halogenated C 1-6 alkyl, NH 2 -C 1-6 alkylene or any combination thereof.

[0055] In some embodiments of the compound of Formula (I-2), R a1 represents the following formula:

[0056] In some embodiments of the compound of Formula (I-2), L 1 represents the structure of the following formula:         ##-(C(R a1< )(R a2< )) m1 -(R e2 (C(R a3< )(R a4< )) m2 ) p1 -;         ##-(C(R a1< )(R a2< )) m1 -(R e2 (C(R a3< )(R a4< )) m2 ) p1 -(R e2 (C(R a5< )(R a6< )) m3 ) p2 -;         ##-(C(R a1< )(R a2< )) m1 -(R e2 (C(R a3< )(R a4< )) m2 ) p1- (R e2 (C(R a5< )(R a6< )) m3 ) p2 -(Re 2 (C(R a7< )(R a8< )) m4 ) p3 -;         ##-(C(R a1< )(R a2< )) m1 -(R e3 (C(R a3< )(R a4< )) m2 ) p1 -;         ##-(C(R a1< )(R a2< )) m1 -(R e3 (C(R a3< )(R a4< )) m2 ) p1 -(R e3 (C(R a5< )(R a6< )) m3 ) p2 -;         ##-(C(R a1< )(R a2< )) m1 -(R e3 (C(R a3< )(R a4< )) m2 ) p1 -(R e3 (C(R a5< )(R a6< ) m3 ) p2 -(R e3< (C(R a7< )(R a8< )) m4 ) p3 -; ##-(C(R a1< )(R a2< )) m1 -(R e3 (C(R a3< )(R a4< )) m2 ) p1 -(R e3 (C(R a5< )(R a6< )) m3 ) p2 -(R e3 (C(R a7< )(R a8< )) m4 ) p3 -;          ##< -(C(R a1< )(R a2< )) m1 -(R e2 -R e3 -(C(R a3< )(R a4< )) m2 ) p1 -;         ##-(C(R a1< )(R a2< )) m1 -(R e2 (C(R a3< )(R a4< )) m2 ) p1 -(R e3 (C(R a5< )(R a6< )) m3 ) p2 -;         ##-(C(R a1< )(R a2< )) m1 -(R e3 -R e2 -(C(R a3< )(R a4< )) m2 ) p1 -; or         ##-(C(R a1< )(R a2< )) m1 -(R e3 (C(R a3< )(R a4< )) m2 ) p1 -(R e2 (C(R a5< )(R a6< )) m3 ) p2 -; wherein each group R e2 is independently selected from the group consisting of O, S, N(R e4 ), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O) 2 , S(O) 2 O, OS(O) 2 , S(O) 2 NH or NHS(O) 2 , wherein each R e4 independently represents H or C 1-3 alkyl; and each group R e3 is independently selected from the group consisting of optionally substituted C 3-15 cycloalkylene, optionally substituted 4- to 15-membered heterocyclylene, optionally substituted C 6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C 2-6 alkenylene, C 2-6 alkynylene or any combination thereof, wherein the C 3-15 cycloalkylene, the C 6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C 1-6 alkyl (e.g., optionally deuterated C 1-4 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C 3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 alkoxy (e.g., C 1-3 alkoxy, such as methoxy, ethoxy, or propoxy), optionally deuterated C 1-6 alkyl-NH- (e.g., C 1-3 alkyl-NH-, such as CH 3 NH-, CH 3 CH 2 NH- or CH 3 CH 2 CH 2 NH-), halogenated C 1-6 alkyl (e.g., halogenated C 1-3 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), NH 2 -C 1-6 alkylene (e.g., NH 2 -C 1-3 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - and NH 2 CH 2 CH 2 CH 2 -), optionally deuterated C 1-6 alkyl-NHC(O)- (e.g., C 1-4 alkyl-NHC(O)-, such as CH 3 -NHC(O)-, CH 3 CH 2 -NHC(O)-, and CH 3 CH 2 CH 2 -NHC(O)-), optionally deuterated C 1-6 alkyl-C(O)NH-(e.g., C 1-4 alkyl-C(O)NH-, such as CH 3 -C(O)NH-, CH 3 CH 2 -C(O)NH-, and CH 3 CH 2 CH 2 -C(O)NH-) or any combination thereof; R a1< , R a2< , R a3< , R a4< , R a5< , R a6< , R a7< and R a8< each independently represent H, deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C 1-6 alkyl (e.g., optionally deuterated C 1-4 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), halogenated C 1-6 alkyl (e.g., halogenated C 1-3 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), optionally deuterated C 3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), optionally deuterated C 1-6 alkoxy (e.g., C 1-3 alkoxy, such as methoxy, ethoxy, or propoxy), optionally deuterated C 1-6 alkyl-NH- (e.g., C 1-3 alkyl-NH-, such as CH 3 NH-, CH 3 CH 2 NH- or CH 3 CH 2 CH 2 NH-), NH 2 -C 1-6 alkylene (e.g., NH 2 -C 1-3 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - and NH 2 CH 2 CH 2 CH 2 -), optionally deuterated C 1-6 alkyl-NHC(O)- (e.g., C 1-4 alkyl-NHC(O)-, such as CH 3 -NHC(O)-, CH 3 CH 2 -NHC(O)-, and CH 3 CH 2 CH 2 -NHC(O)-), optionally deuterated C 1-6 alkyl-C(O)NH- (e.g., C 1-4 alkyl-C(O)NH-, such as CH 3 -C(O)NH-, CH 3 CH 2 -C(O)NH-, and CH 3 CH 2 CH 2 -C(O)NH-) or any combination thereof; symbol ## indicates the point of attachment to X 1 ; and m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

[0057] In some embodiments of the compound of Formula (I-2), L 1 represents the structure of the following formula:         ##-(C(R a1< )(R a2< )) m1 -(O(C(R a3< )(R a4< )) m2 ) p1 -;         ##-(C(R a1< )(R a2< )) m1 -(O(C(R a3< )(R a4< )) m2 ) p1 -(O(C(R a5< )(R a6< )) m3 ) p2 -;         ##-(C(R a1< )(R a2< )) m1 -(O(C(R a3< )(R a4< )) m2 ) p1 -(O(C(R a5< )(R a6< ) m3 ) p2 -(O(C(R a7< )(R a8< ) m4 ) p3 -;         ##-(C(R a1< )(R a2< )) m1 -(N(R g9 )(C(R a3< )(R a4< )) m2 ) p1 -;         ##-(C(R a1< )(R a2< )) m1 -(N(R g9 )(C(R a3< )(R a4< )) m2 ) p1 -(N(R g9 )(C(R a5< )(R a6< )) m3 ) p2 -; ##-(C(R a1< )(R a2< )) m1 -(N(R g9 )(C(R a3< )(R a4< ) m2 ) p1 -(N(R g9 )(C(R a5< )(R a6< )) m3 ) p2 -;         ##-(C(R a1< )(R a2< )) m1 -(N(R g9 )(C(R a3< )(R a4< )) m2 ) p1 -(N(R g9 )(C(R a5< )(R a6< )) m3 ) p2 -(N(R g9 )(C(R a7< )(R a8< )) m4 ) p3 -;         ##-(C(R a1< )(R a2< ) m1 -(C(O)NH-(C(R a3< )(R a4< ) m2 ) p1 -;         ##-(C(R a1< )(R a2< )) m1 -(C(O)NH-(C(R a3< )(R a4< ) m2 ) p1 -(C(O)NH-(C(R a5< )(R a6< )) m3 ) p2 -;         ##-(C(R a1< )(R a2< )) m1 -(C(O)NH-(C(O)NH-(C(R a3< )(R a4< )) m2 ) p1 -(C(O)NH-(C(R a5< )(R a6< )) m3 ) p2 -(C(O)NH-         (C(R a7< )(R a8< )) m4 ) p3 -;         ##-(C(R a1< )(R a2< )) m1 -(C(O)NH-(C(R a3< )(R a4< ) m2 ) p1 -(O-(C(R a5< )(R a6< )) m3 ) p2 -;         ##-(C(R a1< )(R a2< )) m1 -C(O)NH-(C(R a3< )(R a4< )) m2 -(O(C(R a5< )(R a6< )) m3 ) p1 -;         ##-(C(R a1< )(R a2< )) m1 -(NHC(O)-(C(R a3< )(R a4< )) m2 ) p1 -;         ##-(C(R a1< )(R a2< )) m1 -(NHC(O)-(C(R a3< )(R a4< )) m2 ) p1 -(O-(C(R a5< )(R a6< )) m3 ) p2 -;         ##-(C(R a1< )(R a2< )) m1 -(NHC(O)-(C(R a3< )(R a4< )) m2 ) p1 -(O-(C(R a5< )(R a6< )) m3 ) p2 -(O-(C(R a7< )(R a8< )) m4 ) p3 -;         ##-(C(R a1< )(R a2< )) m1 -NHC(O)-(C(R a3< )(R a4< )) m2 -(O(C(R a5< )(R a6< )) m3 ) p1 -;         ##-(C(R a1< )(R a2< )) m1 -NHC(O)NH-(C(R a3< )(R a4< )) m2 -;         ##-(C(R a1< )(R a2< )) m1 -C(O)-(C(R a3< )(R a4< )) m2 -;         ##-(C(R a1< )(R a2< ) m1 -C(S)-(C(R a3< )(R a4< )) m2 -;         ##-(C(R a1< )(R a2< )) m1 -S-(C(R a3< )(R a4< )) m2 -;         ##-(C(R a1< )(R a2< )) m1 -(C 6-10 arylene-(C(R a3< )(R a4< )) m2 ) p1 -;         ##-(C(R a1< )(R a2< )) m1 -(C 6-10 arylene-(C(R a3< )(R a4< )) m2 ) p1 -C 6-10 arylene-(C(R a5< )(R a6< )) m3 -;         ##-(C(R a1< )(R a2< )) m1 -(4- to 15-membered heterocyclylene-(C(R a3< )(R a4< )) m2 ) p1 -;         ##-(C(R a1< )(R a2< )) m1 -(4- to 15-membered heterocyclylene-(C(R a3< )(R a4< )) m2 ) p1 -(4- to 15-membered heterocyclylene-(C(R a5< )(R a6< )) m3 ) p2 -;         ##-(C(R a1< )(R a2< )) m1 -(5- to 15-membered heteroarylene-(C(R a3< )(R a4< )) m2 ) p1 -;         ##-(C(R a1< )(R a2< )) m1 -(5- to 15-membered heteroarylene-(C(R a3< )(R a4< )) m2 ) p1 -(5- to 15-membered heteroarylene-(C(R a5< )(R a6< )) m3 ) p2 -;         ##-(C(R a1< )(R a2< )) m1 -(C 3-15 cycloalkylene-(C(R a3< )(R a4< )) m2 ) p1 -; or         ##-(C(R a1< )(R a2< )) m1 -(C 3-15 cycloalkylene-(C(R a3< )(R a4< )) m2 ) p1 -(C 3-15 cycloalkylene-(C(R a5< )(R a6< )) m3 ) p2 -; wherein each R g9 independently represents H or C 1-3 alkyl; the C 3-15 cycloalkylene, the C 6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, optionally deuterated C 1-6 alkoxy, optionally deuterated C 1-6 alkyl-NH-, halogenated C 1-6 alkyl, NH 2 -C 1-6 alkylene, optionally deuterated C 1-6 alkyl-NHC(O)-, optionally deuterated C 1-6 alkyl-C(O)NH-, cyano or any combination thereof; R a1< , R a2< , R a3< , R a4< , R a5< , R a6< , R a7< and R a8< each independently represent H, deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C 1-6 alkyl, halogenated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, optionally deuterated C 1-6 alkoxy, optionally deuterated C 1-6 alkyl-NH-, NH 2 -C 1-6 alkylene, optionally deuterated C 1-6 alkyl-NHC(O)-, optionally deuterated C 1-6 alkyl-C(O)NH- or any combination thereof; symbol ## indicates the point of attachment to X 1 ; and m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

[0058] In some embodiments of the compound of Formula (I-2), L 1 represents the following group: ##-CH 2 -O-CH 2 -, ##-CH 2 -O-(CH 2 ) 2 -, ##-(CH 2 ) 1 -O-(CH 2 ) 3 -, ##-(CH 2 ) 1 -O-(CH 2 ) 4 -, ##-(CH 2 ) 1 -O-(CH 2 ) 5 -, ##-(CH 2 ) 1 -O-(CH 2 ) 6 -, ##-(CH 2 ) 1 -O-(CH 2 ) 7 -, ##-(CH 2 ) 1 -O-(CH 2 ) 8 -, ##-(CH 2 ) 1 -O-(CH 2 ) 9 -, ##-(CH 2 ) 1 -O-(CH 2 ) 10 -, ##-(CH 2 ) 2 -O-(CH 2 ) 1 -, ##-(CH 2 ) 2 -O-(CH 2 ) 2 -, ##-(CH 2 ) 2 -O-(CH 2 ) 3 -, ##-(CH 2 ) 2 -O-(CH 2 ) 4 -, ##-(CH 2 ) 2 -O-(CH 2 ) 5 -, ##-(CH 2 ) 2 -O-(CH 2 ) 6 -, ##-(CH 2 ) 2 -O-(CH 2 ) 7 -, ##-(CH 2 ) 2 -O-(CH 2 ) 8 -, ##-(CH 2 ) 2 -O-(CH 2 ) 9 -, ##-(CH 2 ) 2 -O-(CH 2 ) 10 -, ##-(CH 2 ) 2 -O-(CH 2 ) 11 -, ##-(CH 2 ) 2 -O-(CH 2 ) 12 -, ##-(CH 2 ) 3 -O-(CH 2 ) 1 -, ##-(CH 2 ) 3 -O-(CH 2 ) 2 -, ##-(CH 2 ) 3 -O-(CH 2 ) 3 -, ##-(CH 2 ) 3 -O-(CH 2 ) 4 -, ##-(CH 2 ) 3 -O-(CH 2 ) 5 -, ##-(CH 2 ) 3 -O-(CH 2 ) 6 -, ##-(CH 2 ) 3 -O-(CH 2 ) 7 -, ##-(CH 2 ) 4 -O-(CH 2 ) 1 -, ##-(CH 2 ) 4 -O-(CH 2 ) 2 -, ##-(CH 2 ) 4 -O-(CH 2 ) 3 -, ##-(CH 2 ) 4 -O-(CH 2 ) 4 -, ##-(CH 2 ) 4 -O-(CH 2 ) 5 -, ##-(CH 2 ) 4 -O-(CH 2 ) 6 -, ##-(CH 2 ) 5 -O-(CH 2 ) 1 -, ##-(CH 2 ) 5 -O-(CH 2 ) 2 -, ##-(CH 2 ) 5 -O-(CH 2 ) 3 -, ##-(CH 2 ) 5 -O-(CH 2 ) 4 -, ##-(CH 2 ) 5 -O-(CH 2 ) 5 -, ##-(CH 2 ) 6 -O-(CH 2 ) 1 -, ##-(CH 2 ) 6 -O-(CH 2 ) 2 -, ##-(CH 2 ) 6 -O-(CH 2 ) 3 -, ##-(CH 2 ) 6 -O-(CH 2 ) 4 -, ##-(CH 2 ) 7 -O-(CH 2 ) 1 -, ##-(CH 2 ) 7 -O-(CH 2 ) 2 -, ##-(CH 2 ) 7 -O-(CH 2 ) 3 -, ##-(CH 2 ) 8 -O-(CH 2 ) 1 -, ##-(CH 2 ) 8 -O-(CH 2 ) 2 -, ##-CH(CH 3 )-O-(CH 2 ) 1 -, ##-CH(CH 3 )-O-(CH 2 ) 2 -, ##-CH(CH 3 )-O-(CH 2 ) 3 -, ##-CH(CH 3 )-O-(CH 2 ) 4 -, ##-CH(CH 3 )-O-(CH 2 ) 5 -, ##-CH(CH 3 )-O-(CH 2 ) 6 -, ##-CH(CH 3 )-O-(CH 2 ) 7 -, ##-CH(CH 3 )-O-(CH 2 ) 8 -, ##-CH(CH 3 )-O-(CH 2 ) 9 -, ##-CH(CH 3 )-O-(CH 2 ) 10 -, ##-CH 2 -(O(CH 2 ) 2 ) 2 -, ##-CH 2 -(O(CH 2 ) 2 ) 3 -, ##-CH 2 -(O(CH 2 ) 2 ) 4 -, ##-CH 2 -(O(CH 2 ) 2 ) 5 -, ##-CH 2 -(O(CH 2 ) 2 ) 6 -, ##-CH 2 -(O(CH 2 ) 2 ) 7 -, ##-CH 2 -(O(CH 2 ) 2 ) 8 -, ##-CH 2 -(O(CH 2 ) 2 ) 9 -, ##-CH 2 -(O(CH 2 ) 2 ) 10 -, ##-CH 2 -(O(CH 2 ) 2 ) 1 -OCH 2 -, ##-CH 2 -(O(CH 2 ) 2 ) 2 -OCH 2 -, ##-CH 2 -(O(CH 2 ) 2 ) 3 -OCH 2 -, ##-CH 2 -(O(CH 2 ) 2 ) 4 -OCH 2 -, ##-CH 2 -(O(CH 2 ) 2 ) 5 -OCH 2 -, ##-CH 2 -(O(CH 2 ) 2 ) 6 -OCH 2 -, ##-CH 2 -(O(CH 2 ) 2 ) 7 -OCH 2 -, ##-CH 2 -(O(CH 2 ) 2 ) 8 -OCH 2 -, ##-CH 2 -(O(CH 2 ) 2 ) 9 -OCH 2 -, ##-CH 2 -(O(CH 2 ) 2 ) 10 -OCH 2 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 2 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 3 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 4 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 5 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 6 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 7 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 8 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 9 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 10 -, ##-(CH 2 ) 3 -(O(CH 2 ) 2 ) 2 -, ##-(CH 2 ) 3 -(O(CH 2 ) 2 ) 3 -, ##-(CH 2 ) 3 -(O(CH 2 ) 2 ) 4 -, ##-(CH 2 ) 3 -(O(CH 2 ) 2 ) 5 -, ##-(CH 2 ) 3 -(O(CH 2 ) 2 ) 6 -, ##-(CH 2 ) 3 -(O(CH 2 ) 2 ) 7 -, ##-(CH 2 ) 3 -(O(CH 2 ) 2 ) 8 -, ##-(CH 2 ) 3 -(O(CH 2 ) 2 ) 9 -, ##-(CH 2 ) 3 -(O(CH 2 ) 2 ) 10 -, ##-(CH 2 ) 4 -(O(CH 2 ) 2 ) 2 -, ##-(CH 2 ) 4 -(O(CH 2 ) 2 ) 3 -, ##-(CH 2 ) 4 -(O(CH 2 ) 2 ) 4 -, ##-(CH 2 ) 4 -(O(CH 2 ) 2 ) 5 -, ##-(CH 2 ) 4 -(O(CH 2 ) 2 ) 6 -, ##-(CH 2 ) 4 -(O(CH 2 ) 2 ) 7 -, ##-(CH 2 ) 4 -(O(CH 2 ) 2 ) 8 -, ##-(CH 2 ) 4 -(O(CH 2 ) 2 ) 9 -, ##-(CH 2 ) 4 -(O(CH 2 ) 2 ) 10 -, ##-CH 2 -(O(CH 2 ) 3 ) 2 -, ##-CH 2 -(O(CH 2 ) 3 ) 3 -, ##-CH 2 -(O(CH 2 ) 3 ) 4 -, ##-CH 2 -(O(CH 2 ) 3 ) 5 -, ##-CH 2 -(O(CH 2 ) 3 ) 6 -, ##-CH 2 -(O(CH 2 ) 3 ) 7 -, ##-CH 2 -(O(CH 2 ) 3 ) 8 -, ##-CH 2 -(O(CH 2 ) 3 ) 9 -, ##-CH 2 -(O(CH 2 ) 3 ) 10 -, ##-(CH 2 ) 2 -(O(CH 2 ) 3 ) 2 -, ##-(CH 2 ) 2 -(O(CH 2 ) 3 ) 3 -, ##-(CH 2 ) 2 -(O(CH 2 ) 3 ) 4 -, ##-(CH 2 ) 2 -(O(CH 2 ) 3 ) 5 -, ##-(CH 2 ) 2 -(O(CH 2 ) 3 ) 6 -, ##-(CH 2 ) 2 -(O(CH 2 ) 3 ) 7 -, ##-(CH 2 ) 2 -(O(CH 2 ) 3 ) 8 -, ##-(CH 2 ) 2 -(O(CH 2 ) 3 ) 9 -, ##-(CH 2 ) 2 -(O(CH 2 ) 3 ) 10 -, ##-(CH 2 ) 3 -(O(CH 2 ) 3 ) 2 -, ##-(CH 2 ) 3 -(O(CH 2 ) 3 ) 3 -, ##-(CH 2 ) 3 -(O(CH 2 ) 3 ) 4 -, ##-(CH 2 ) 3 -(O(CH 2 ) 3 ) 5 -, ##-(CH 2 ) 3 -(O(CH 2 ) 3 ) 6 -, ##-(CH 2 ) 3 -(O(CH 2 ) 3 ) 7 -, ##-(CH 2 ) 3 -(O(CH 2 ) 3 ) 8 -, ##-(CH 2 ) 3 -(O(CH 2 ) 3 ) 9 -, ##-(CH 2 ) 3 -(O(CH 2 ) 3 ) 10 -, ##-CH 2 -O-(CH 2 ) 2 -O-(CH 2 ) 3 -, ##-CH 2 -(O(CH 2 ) 2 ) 2 -(O(CH 2 ) 3 ) 2 -, ##-CH 2 -(O(CH 2 ) 2 ) 3 -(O(CH 2 ) 3 ) 3 -, ##-CH 2 -(O(CH 2 ) 2 ) 4 -(O(CH 2 ) 3 ) 4 -, ##-CH 2 -(O(CH 2 ) 2 ) 5 -(O(CH 2 ) 3 ) 5 -, ##-CH 2 -(O(CH 2 ) 2 ) 6 -(O(CH 2 ) 3 ) 6 -, ##-(CH 2 ) 2 -O-(CH 2 ) 2 -O-(CH 2 ) 3 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 2 -(O(CH 2 ) 3 ) 2 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 3 -(O(CH 2 ) 3 ) 3 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 4 -(O(CH 2 ) 3 ) 4 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 5 -(O(CH 2 ) 3 ) 5 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 6 -(O(CH 2 ) 3 ) 6 -, ##-(CH 2 ) 3 -O-(CH 2 ) 2 -O-(CH 2 ) 3 -, ##-(CH 2 ) 3 -(O(CH 2 ) 2 ) 2 -(O(CH 2 ) 3 ) 2 -, ##-(CH 2 ) 3 -(O(CH 2 ) 2 ) 3 -(O(CH 2 ) 3 ) 3 -, ##-(CH 2 ) 3 -(O(CH 2 ) 2 ) 4 -(O(CH 2 ) 3 ) 4 -, ##-(CH 2 ) 3 -(O(CH 2 ) 2 ) 5 -(O(CH 2 ) 3 ) 5 -, ##-(CH 2 ) 3 -(O(CH 2 ) 2 ) 6 -(O(CH 2 ) 3 ) 6 -, ##-CH 2 -O-(CH 2 ) 3 -O-(CH 2 ) 2 -, ##-CH 2 -(O(CH 2 ) 3 ) 2 -(O(CH 2 ) 2 ) 2 -, ##-CH 2 -(O(CH 2 ) 3 ) 3 -(O(CH 2 ) 2 ) 3 -, ##-CH 2 -(O(CH 2 ) 3 ) 4 -(O(CH 2 ) 2 ) 4 -, ##-CH 2 -(O(CH 2 ) 3 ) 5 -(O(CH 2 ) 2 ) 5 -, ##-CH 2 -(O(CH 2 ) 3 ) 6 -(O(CH 2 ) 2 ) 6 -, ##-(CH 2 ) 2 -O-(CH 2 ) 3 -O-(CH 2 ) 2 -, ##-(CH 2 ) 2 -(O(CH 2 ) 3 ) 2 -(O(CH 2 ) 2 ) 2 -, ##-(CH 2 ) 2 -(O(CH 2 ) 3 ) 3 -(O(CH 2 ) 2 ) 3 -, ##-(CH 2 ) 2 -(O(CH 2 ) 3 ) 4 -(O(CH 2 ) 2 ) 4 -, ##-(CH 2 ) 2 -(O(CH 2 ) 3 ) 5 -(O(CH 2 ) 2 ) 5 -, ##-(CH 2 ) 2 -(O(CH 2 ) 3 ) 6 -(O(CH 2 ) 2 ) 6 -, ##-(CH 2 ) 3 -O-(CH 2 ) 3 -O-(CH 2 ) 2 -, ##-(CH 2 ) 3 -(O(CH 2 ) 3 ) 2 -(O(CH 2 ) 2 ) 2 -, ##-(CH 2 ) 3 -(O(CH 2 ) 3 ) 3 -(O(CH 2 ) 2 ) 3 -, ##-(CH 2 ) 3 -(O(CH 2 ) 3 ) 4 -(O(CH 2 ) 2 ) 4 -, ##-(CH 2 ) 3 -(O(CH 2 ) 3 ) 5 -(O(CH 2 ) 2 ) 5 -, ##-(CH 2 ) 3 -(O(CH 2 ) 3 ) 6 -(O(CH 2 ) 2 ) 6 -, ##-CH 2 -O-(CH 2 ) 2 -O-CH 2 -, ##-(CH 2 ) 2 -O-(CH 2 ) 2 -O-CH 2 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 2 -O-(CH 2 ) 3 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 3 -O-(CH 2 ) 3 -, ##-(CH 2 ) 2 -(O(CH 2 ) 2 ) 4 -O-(CH 2 ) 3 -, ##-(CH 2 ) 5 -(O(CH 2 ) 2 ) 2 -O-(CH 2 ) 5 -, ##-(CH 2 ) 5 -(O(CH 2 ) 2 ) 2 -O-(CH 2 ) 6 -, ##-CH 2 -C(O)-CH 2 -, ##-CH 2 -C(O)-(CH 2 ) 2 -, ##-(CH 2 ) 1 -C(O)-(CH 2 ) 3 -, ##-(CH 2 ) 1 -C(O)-(CH 2 ) 4 -, ##-(CH 2 ) 1 -C(O)-(CH 2 ) 5 -, ##-(CH 2 ) 1 -C(O)-(CH 2 ) 6 -, ##-(CH 2 ) 1 -C(O)-(CH 2 ) 7 -, ##-(CH 2 ) 1 -C(O)-(CH 2 ) 8 -, ##-(CH 2 ) 1 -C(O)-(CH 2 ) 9 -, ##-(CH 2 ) 1 -C(O)-(CH 2 ) 10 -, ##-(CH 2 ) 2 -C(O)-(CH 2 ) 1 -, ##-(CH 2 ) 2 -C(O)-(CH 2 ) 2 -, ##-(CH 2 ) 2 -C(O)-(CH 2 ) 3 -, ##-(CH 2 ) 2 -C(O)-(CH 2 ) 4 -, ##-(CH 2 ) 2 -C(O)-(CH 2 ) 5 -, ##-(CH 2 ) 2 -C(O)-(CH 2 ) 6 -, ##-(CH 2 ) 2 -C(O)-(CH 2 ) 7 -, ##-(CH 2 ) 2 -C(O)-(CH 2 ) 8 -, ##-(CH 2 ) 2 -C(O)-(CH 2 ) 9 -, ##-(CH 2 ) 2 -C(O)-(CH 2 ) 10 -, ##-(CH 2 ) 2 -C(O)-(CH 2 ) 11 -, ##-(CH 2 ) 2 -C(O)-(CH 2 ) 12 -, ##-(CH 2 ) 3 -C(O)-(CH 2 ) 1 -, ##-(CH 2 ) 3 -C(O)-(CH 2 ) 2 -, ##-(CH 2 ) 3 -C(O)-(CH 2 ) 3 -, ##-(CH 2 ) 3 -C(O)-(CH 2 ) 4 -, ##-(CH 2 ) 3 -C(O)-(CH 2 ) 5 -, ##-(CH 2 ) 3 -C(O)-(CH 2 ) 6 -, ##-(CH 2 ) 3 -C(O)-(CH 2 ) 7 -, ##-(CH 2 ) 4 -C(O)-(CH 2 ) 1 -, ##-(CH 2 ) 4 -C(O)-(CH 2 ) 2 -, ##-(CH 2 ) 4 -C(O)-(CH 2 ) 3 -, ##-(CH 2 ) 4 -C(O)-(CH 2 ) 4 -, ##-(CH 2 ) 4 -C(O)-(CH 2 ) 5 -, ##-(CH 2 ) 4 -C(O)-(CH 2 ) 6 -, ##-(CH 2 ) 5 -C(O)-(CH 2 ) 1 -, ##-(CH 2 ) 5 -C(O)-(CH 2 ) 2 -, ##-(CH 2 ) 5 -C(O)-(CH 2 ) 3 -, ##-(CH 2 ) 5 -C(O)-(CH 2 ) 4 -, ##-(CH 2 ) 5 -C(O)-(CH 2 ) 5 -, ##-(CH 2 ) 6 -C(O)-(CH 2 ) 1 -, ##-(CH 2 ) 6 -C(O)-(CH 2 ) 2 -, ##-(CH 2 ) 6 -C(O)-(CH 2 ) 3 -, ##-(CH 2 ) 6 -C(O)-(CH 2 ) 4 -, ##-(CH 2 ) 7 -C(O)-(CH 2 ) 1 -, ##-(CH 2 ) 7 -C(O)-(CH 2 ) 2 -, ##-(CH 2 ) 7 -C(O)-(CH 2 ) 3 -, ##-(CH 2 ) 8 -C(O)-(CH 2 ) I -, ##-(CH 2 ) 8 -C(O)-(CH 2 ) 2 -, ##-CH 2 -S-CH 2 -, ##-CH 2 -S-(CH 2 ) 2 -, ##-(CH 2 ) 1 -S-(CH 2 ) 3 -, ##-(CH 2 ) 1 -S-(CH 2 ) 4 -, ##-(CH 2 ) 1 -S-(CH 2 ) 5 -, ##-(CH 2 ) 1 -S-(CH 2 ) 6 -, ##-(CH 2 ) 1 -S-(CH 2 ) 7 -, ##-(CH 2 ) 1 -S-(CH 2 ) 8 -, ##-(CH 2 ) 1 -S-(CH 2 ) 9 -, ##-(CH 2 ) 1 -S-(CH 2 ) 10 -, ##-(CH 2 ) 2 -S-(CH 2 ) 1 -, ##-(CH 2 ) 2 -S-(CH 2 ) 2 -, ##-(CH 2 ) 2 -S-(CH 2 ) 3 -, ##-(CH 2 ) 2 -S-(CH 2 ) 4 -, ##-(CH 2 ) 2 -S-(CH 2 ) 5 -, ##-(CH 2 ) 2 -S-(CH 2 ) 6 -, ##-(CH 2 ) 2 -S-(CH 2 ) 7 -, ##-(CH 2 ) 2 -S-(CH 2 ) 8 -, ##-(CH 2 ) 2 -S-(CH 2 ) 9 -, ##-(CH 2 ) 2 -S-(CH 2 ) 10 -, ##-(CH 2 ) 2 -S-(CH 2 ) 11 -, ##-(CH 2 ) 2 -S-(CH 2 ) 12 -, ##-(CH 2 ) 3 -S-(CH 2 ) 1 -, ##-(CH 2 ) 3 -S-(CH 2 ) 2 -, ##-(CH 2 ) 3 -S-(CH 2 ) 3 -, ##-(CH 2 ) 3 -S-(CH 2 ) 4 -, ##-(CH 2 ) 3 -S-(CH 2 ) 5 -, ##-(CH 2 ) 3 -S-(CH 2 ) 6 -, ##-(CH 2 ) 3 -S-(CH 2 ) 7 -, ##-(CH 2 ) 4 -S-(CH 2 ) 1 -, ##-(CH 2 ) 4 -S-(CH 2 ) 2 -, ##-(CH 2 ) 4 -S-(CH 2 ) 3 -, ##-(CH 2 ) 4 -S-(CH 2 ) 4 -, ##-(CH 2 ) 4 -S-(CH 2 ) 5 -, ##-(CH 2 ) 4 -S-(CH 2 ) 6 -, ##-(CH 2 ) 5 -S-(CH 2 ) 1 -, ##-(CH 2 ) 5 -S-(CH 2 ) 2 -, ##-(CH 2 ) 5 -S-(CH 2 ) 3 -, ##-(CH 2 ) 5 -S-(CH 2 ) 4 -, ##-(CH 2 ) 5 -S-(CH 2 ) 5 -, ##-(CH 2 ) 6 -S-(CH 2 ) 1 -, ##-(CH 2 ) 6 -S-(CH 2 ) 2 -, ##-(CH 2 ) 6 -S-(CH 2 ) 3 -, ##-(CH 2 ) 6 -S-(CH 2 ) 4 -, ##-(CH 2 ) 7 -S-(CH 2 ) 1 -, ##-(CH 2 ) 7 -S-(CH 2 ) 2 -, ##-(CH 2 ) 7 -S-(CH 2 ) 3 -, ##-(CH 2 ) 8 -S-(CH 2 ) 1 -, ##-(CH 2 ) 8 -S-(CH 2 ) 2 -, ##-CH 2 -C(S)-CH 2 -, ##-CH 2 -C(S)-(CH 2 ) 2 -, ##-(CH 2 ) 1 -C(S)-(CH 2 ) 3 -, ##-(CH 2 ) 1 -C(S)-(CH 2 ) 4 -, ##-(CH 2 ) 1 -C(S)-(CH 2 ) 5 -, ##-(CH 2 ) 1 -C(S)-(CH 2 ) 6 -, ##-(CH 2 ) 1 -C(S)-(CH 2 ) 7 -, ##-(CH 2 ) 1 -C(S)-(CH 2 ) 8 -, ##-(CH 2 ) 1 -C(S)-(CH 2 ) 9 -, ##-(CH 2 ) 1 -C(S)-(CH 2 ) 10 -, ##-(CH 2 ) 2 -C(S)-(CH 2 ) 1 -, ##-(CH 2 ) 2 -C(S)-(CH 2 ) 2 -, ##-(CH 2 ) 2 -C(S)-(CH 2 ) 3 -, ##-(CH 2 ) 2 -C(S)-(CH 2 ) 4 -, ##-(CH 2 ) 2 -C(S)-(CH 2 ) 5 -, ##-(CH 2 ) 2 -C(S)-(CH 2 ) 6 -, ##-(CH 2 ) 2 -C(S)-(CH 2 ) 7 -, ##-(CH 2 ) 2 -C(S)-(CH 2 ) 8 -, ##-(CH 2 ) 2 -C(S)-(CH 2 ) 9 -, ##-(CH 2 ) 2 -C(S)-(CH 2 ) 10 -, ##-(CH 2 ) 2 -C(S)-(CH 2 ) 11 -, ##-(CH 2 ) 2 -C(S)-(CH 2 ) 12 -, ##-(CH 2 ) 3 -C(S)-(CH 2 ) 1 -, ##-(CH 2 ) 3 -C(S)-(CH 2 ) 2 -, ##-(CH 2 ) 3 -C(S)-(CH 2 ) 3 -, ##-(CH 2 ) 3 -C(S)-(CH 2 ) 4 -, ##-(CH 2 ) 3 -C(S)-(CH 2 ) 5 -, ##-(CH 2 ) 3 -C(S)-(CH 2 ) 6 -, ##-(CH 2 ) 3 -C(S)-(CH 2 ) 7 -, ##-(CH 2 ) 4 -C(S)-(CH 2 ) 1 -, ##-(CH 2 ) 4 -C(S)-(CH 2 ) 2 -, ##-(CH 2 ) 4 -C(S)-(CH 2 ) 3 -, ##-(CH 2 ) 4 -C(S)-(CH 2 ) 4 -, ##-(CH 2 ) 4 -C(S)-(CH 2 ) 5 -, ##-(CH 2 ) 4 -C(S)-(CH 2 ) 6 -, ##-(CH 2 ) 5 -C(S)-(CH 2 ) 1 -, ##-(CH 2 ) 5 -C(S)-(CH 2 ) 2 -, ##-(CH 2 ) 5 -C(S)-(CH 2 ) 3 -, ##-(CH 2 ) 5 -C(S)-(CH 2 ) 4 -, ##-(CH 2 ) 5 -C(S)-(CH 2 ) 5 -, ##-(CH 2 ) 6 -C(S)-(CH 2 ) 1 -, ##-(CH 2 ) 6 -C(S)-(CH 2 ) 2 -, ##-(CH 2 ) 6 -C(S)-(CH 2 ) 3 -, ##-(CH 2 ) 6 -C(S)-(CH 2 ) 4 -, ##-(CH 2 ) 7 -C(S)-(CH 2 ) 1 -, ##-(CH 2 ) 7 -C(S)-(CH 2 ) 2 -, ##-(CH 2 ) 7 -C(S)-(CH 2 ) 3 -, ##-(CH 2 ) 8 -C(S)-(CH 2 ) 1 -, ##-(CH 2 ) 8 -C(S)-(CH 2 ) 2 -, ##-CH 2 -C(O)O-CH 2 -, ##-CH 2 -C(O)O-(CH 2 ) 2 -, ##-(CH 2 ) 1 -C(O)O-(CH 2 ) 3 -, ##-(CH 2 ) 1 -C(O)O-(CH 2 ) 4 -, ##-(CH 2 ) 1 -C(O)O-(CH 2 ) 5 -, ##-(CH 2 ) 1 -C(O)O-(CH 2 ) 6 -, ##-(CH 2 ) 1 -C(O)O-(CH 2 ) 7 -, ##-(CH 2 ) 1 -C(O)O-(CH 2 ) 8 -, ##-(CH 2 ) 1 -C(O)O-(CH 2 ) 9 -, ##-(CH 2 ) 1 -C(O)O-(CH 2 ) 10 -, ##-(CH 2 ) 2 -C(O)O-(CH 2 ) 1 -, ##-(CH 2 ) 2 -C(O)O-(CH 2 ) 2 -, ##-(CH 2 ) 2 -C(O)O-(CH 2 ) 3 -, ##-(CH 2 ) 2 -C(O)O-(CH 2 ) 4 -, ##-(CH 2 ) 2 -C(O)O-(CH 2 ) 5 -, ##-(CH 2 ) 2 -C(O)O-(CH 2 ) 6 -, ##-(CH 2 ) 2 -C(O)O-(CH 2 ) 7 -, ##-(CH 2 ) 2 -C(O)O-(CH 2 ) 8 -, ##-(CH 2 ) 2 -C(O)O-(CH 2 ) 9 -, ##-(CH 2 ) 2 -C(O)O-(CH 2 ) 10 -, ##-(CH 2 ) 2 -C(O)O-(CH 2 ) 11 -, ##-(CH 2 ) 2 -C(O)O-(CH 2 ) 12 -, ##-(CH 2 ) 3 -C(O)O-(CH 2 ) 1 -, ##-(CH 2 ) 3 -C(O)O-(CH 2 ) 2 -, ##-(CH 2 ) 3 -C(O)O-(CH 2 ) 3 -, ##-(CH 2 ) 3 -C(O)O-(CH 2 ) 4 -, ##-(CH 2 ) 3 -C(O)O-(CH 2 ) 5 -, ##-(CH 2 ) 3 -C(O)O-(CH 2 ) 6 -, ##-(CH 2 ) 3 -C(O)O-(CH 2 ) 7 -, ##-(CH 2 ) 4 -C(O)O-(CH 2 ) 1 -, ##-(CH 2 ) 4 -C(O)O-(CH 2 ) 2 -, ##-(CH 2 ) 4 -C(O)O-(CH 2 ) 3 -, ##-(CH 2 ) 4 -C(O)O-(CH 2 ) 4 -, ##-(CH 2 ) 4 -C(O)O-(CH 2 ) 5 -, ##-(CH 2 ) 4 -C(O)O-(CH 2 ) 6 -, ##-(CH 2 ) 5 -C(O)O-(CH 2 ) 1 -, ##-(CH 2 ) 5 -C(O)O-(CH 2 ) 2 -, ##-(CH 2 ) 5 -C(O)O-(CH 2 ) 3 -, ##-(CH 2 ) 5 -C(O)O-(CH 2 ) 4 -, ##-(CH 2 ) 5 -C(O)O-(CH 2 ) 5 -, ##-(CH 2 ) 6 -C(O)O-(CH 2 ) 1 -, ##-(CH 2 ) 6 -C(O)O-(CH 2 ) 2 -, ##-(CH 2 ) 6 -C(O)O-(CH 2 ) 3 -, ##-(CH 2 ) 6 -C(O)O-(CH 2 ) 4 -, ##-(CH 2 ) 7 -C(O)O-(CH 2 ) 1 -, ##-(CH 2 ) 7 -C(O)O-(CH 2 ) 2 -, ##-(CH 2 ) 7 -C(O)O-(CH 2 ) 3 -, ##-(CH 2 ) 8 -C(O)O-(CH 2 ) 1 -, ##-(CH 2 ) 8 -C(O)O-(CH 2 ) 2 -, ##-CH 2 -OC(O)-CH 2 -, ##-CH 2 -OC(O)-(CH 2 ) 2 -, ##-(CH 2 ) 1 -OC(O)-(CH 2 ) 3 -, ##-(CH 2 ) 1 -OC(O)-(CH 2 ) 4 -, ##-(CH 2 ) 1 -OC(O)-(CH 2 ) 5 -, ##-(CH 2 ) 1 -OC(O)-(CH 2 ) 6 -, ##-(CH 2 ) 1 -OC(O)-(CH 2 ) 7 -, ##-(CH 2 ) 1 -OC(O)-(CH 2 ) 8 -, ##-(CH 2 ) 1 -OC(O)-(CH 2 ) 9 -, ##-(CH 2 ) 1 -OC(O)-(CH 2 ) 10 -, ##-(CH 2 ) 2 -OC(O)-(CH 2 ) 1 -, ##-(CH 2 ) 2 -OC(O)-(CH 2 ) 2 -, ##-(CH 2 ) 2 -OC(O)-(CH 2 ) 3 -, ##-(CH 2 ) 2 -OC(O)-(CH 2 ) 4 -, ##-(CH 2 ) 2 -OC(O)-(CH 2 ) 5 -, ##-(CH 2 ) 2 -OC(O)-(CH 2 ) 6 -, ##-(CH 2 ) 2 -OC(O)-(CH 2 ) 7 -, ##-(CH 2 ) 2 -OC(O)-(CH 2 ) 8 -, ##-(CH 2 ) 2 -OC(O)-(CH 2 ) 9 -, ##-(CH 2 ) 2 -OC(O)-(CH 2 ) 10 -, ##-(CH 2 ) 2 -OC(O)-(CH 2 ) 11 -, ##-(CH 2 ) 2 -OC(O)-(CH 2 ) 12 -, ##-(CH 2 ) 3 -OC(O)-(CH 2 ) 1 -, ##-(CH 2 ) 3 -OC(O)-(CH 2 ) 2 -, ##-(CH 2 ) 3 -OC(O)-(CH 2 ) 3 -, ##-(CH 2 ) 3 -OC(O)-(CH 2 ) 4 -, ##-(CH 2 ) 3 -OC(O)-(CH 2 ) 5 -, ##-(CH 2 ) 3 -OC(O)-(CH 2 ) 6 -, ##-(CH 2 ) 3 -OC(O)-(CH 2 ) 7 -, ##-(CH 2 ) 4 -OC(O)-(CH 2 ) 1 -, ##-(CH 2 ) 4 -OC(O)-(CH 2 ) 2 -, ##-(CH 2 ) 4 -OC(O)-(CH 2 ) 3 -, ##-(CH 2 ) 4 -OC(O)-(CH 2 ) 4 -, ##-(CH 2 ) 4 -OC(O)-(CH 2 ) 5 -, ##-(CH 2 ) 4 -OC(O)-(CH 2 ) 6 -, ##-(CH 2 ) 5 -OC(O)-(CH 2 ) 1 -, ##-(CH 2 ) 5 -OC(O)-(CH 2 ) 2 -, ##-(CH 2 ) 5 -OC(O)-(CH 2 ) 3 -, ##-(CH 2 ) 5 -OC(O)-(CH 2 ) 4 -, ##-(CH 2 ) 5 -OC(O)-(CH 2 ) 5 -, ##-(CH 2 ) 6 -OC(O)-(CH 2 ) 1 -, ##-(CH 2 ) 6 -OC(O)-(CH 2 ) 2 -, ##-(CH 2 ) 6 -OC(O)-(CH 2 ) 3 -, ##-(CH 2 ) 6 -OC(O)-(CH 2 ) 4 -, ##-(CH 2 ) 7 -OC(O)-(CH 2 ) 1 -, ##-(CH 2 ) 7 -OC(O)-(CH 2 ) 2 -, ##-(CH 2 ) 7 -OC(O)-(CH 2 ) 3 -, ##-(CH 2 ) 8 -OC(O)-(CH 2 ) 1 -, ##-(CH 2 ) 8 -OC(O)-(CH 2 ) 2 -, ##-(CH 2 ) 1 -N(R g10 )-(CH 2 ) 1 -, ##-(CH 2 ) 1 -N(R g10 )-(CH 2 ) 2 -, ##-(CH 2 ) 1 -N(R g10 )-(CH 2 ) 3 -, ##-(CH 2 ) 1 -N(R g10 )-(CH 2 ) 4 -, ##-(CH 2 ) 1 -N(R g10 )-(CH 2 ) 5 -, ##-(CH 2 ) 1 -N(R g10 )-(CH 2 ) 6 -, ##-(CH 2 ) 1 -N(R g10 )-(CH 2 ) 7 -, ##-(CH 2 ) 1 -N(R g10 )-(CH 2 ) 8 -, ##-(CH 2 ) 1 -N(R g10 )-(CH 2 ) 9 -, ##-(CH 2 ) 1 -N(R g10 )-(CH 2 ) 10 -, ##-(CH 2 ) 2 -N(R g10 )-(CH 2 ) 1 -, ##-(CH 2 ) 2 -N(R g10 )-(CH 2 ) 2 -, ##-(CH 2 ) 2 -N(R g10 )-(CH 2 ) 3 -, ##-(CH 2 ) 2 -N(R g10 )-(CH 2 ) 4 -, ##-(CH 2 ) 2 -N(R g10 )-(CH 2 ) 5 -, ##-(CH 2 ) 2 -N(R g10 )-(CH 2 ) 6 -, ##-(CH 2 ) 2 -N(R g10 )-(CH 2 ) 7 -, ##-(CH 2 ) 2 -N(R g10 )-(CH 2 ) 8 -, ##-(CH 2 ) 2 -N(R g10 )-(CH 2 ) 9 -, ##-(CH 2 ) 2 -N(R g10 )-(CH 2 ) 10 -, ##-(CH 2 ) 2 -N(R g10 )-(CH 2 ) 11 -, ##-(CH 2 ) 2 -N(R g10 )-(CH 2 ) 12 -, ##-(CH 2 ) 3 -N(R g10 )-(CH 2 ) 1 -, ##-(CH 2 ) 3 -N(R g10 )-(CH 2 ) 2 -, ##-(CH 2 ) 3 -N(R g10 )-(CH 2 ) 3 -, ##-(CH 2 ) 4 -N(R g10 )-(CH 2 ) 1 -, ##-(CH 2 ) 4 -N(R g10 )-(CH 2 ) 2 -, ##-(CH 2 ) 4 -N(R g10 )-(CH 2 ) 3 -, ##-(CH 2 ) 4 -N(R g10 )-(CH 2 ) 4 -, ##-(CH 2 ) 5 -N(R g10 )-(CH 2 ) 1 -, ##-(CH 2 ) 5 -N(R g10 )-(CH 2 ) 2 -, ##-(CH 2 ) 5 -N(R g10 )-(CH 2 ) 3 -, ##-(CH 2 ) 5 -N(R g10 )-(CH 2 ) 4 -, ##-(CH 2 ) 5 -N(R g10 )-(CH 2 ) 5 -, ##-(CH 2 ) 6 -N(R g10 )-(CH 2 ) 1 -, ##-(CH 2 ) 6 -N(R g10 )-(CH 2 ) 2 -, ##-(CH 2 ) 6 -N(R g10 )-(CH 2 ) 3 -, ##-(CH 2 ) 7 -N(R g10 )-(CH 2 ) 1 -, ##-(CH 2 ) 7 -N(R g10 )-(CH 2 ) 2 -, ##-(CH 2 ) 7 -N(R g10 )-(CH 2 ) 3 -, ##-(CH 2 ) 8 -N(R g10 )-(CH 2 ) 1 -, ##-(CH 2 ) 8 -N R g10 )-(CH 2 ) 2 -, ##-(CH 2 ) 8 -N(R g10 )-(CH 2 ) 3 -, ##-CH(CH 3 )-N(R g10 )-(CH 2 ) 1 -, ##-CH(CH 3 )-N(R g10 )-(CH 2 ) 2 -, ##-CH(CH 3 )-N(R g10 )-(CH 2 ) 3 -, ##-CH(CH 3 )-N(R g10 )-(CH 2 ) 4 -, ##-CH(CH 3 )-N(R g10 )-(CH 2 ) 5 -, ##-CH(CH 3 )-N(R g10 )-(CH 2 ) 6 -, ##-CH(CH 3 )-N(R g10 )-(CH 2 ) 7 -, ##-CH(CH 3 )-N(R g10 )-(CH 2 ) 8 -, ##-CH(CH 3 )-N(R g10 )-(CH 2 ) 9 -, ##-CH(CH 3 )-N(R g10 )-(CH 2 ) 10 -, ##-CH 2 C(O)NHCH 2 -, ##-(CH 2 ) 2 C(O)NH(CH 2 ) 2 -, ##-(CH 2 ) 2 C(O)NH(CH 2 ) 3 -, ##-(CH 2 ) 2 C(O)NH(CH 2 ) 4 -, ##-(CH 2 ) 2 C(O)NH(CH 2 ) 5 -, ##-(CH 2 ) 3 C(O)NH(CH 2 ) 3 -, ##-(CH 2 ) 3 C(O)NH(CH 2 ) 4 -, ##-(CH 2 ) 4 C(O)NH(CH 2 ) 4 -, ##-(CH 2 ) 5 C(O)NH(CH 2 ) 5 -, ##-(CH 2 ) 6 C(O)NH(CH 2 ) 7 -, ##-(CH 2 ) 6 C(O)NH(CH 2 ) 6 -, ##-(CH 2 ) 7 C(O)NH(CH 2 ) 7 -, ##-(CH 2 ) 8 C(O)NH(CH 2 ) 8 , ##-(CH 2 ) 9 C(O)NH(CH 2 ) 9 -, ##-(CH 2 ) 10 C(O)NH(CH 2 ) 10 -, ##-(CH 2 ) 2 C(O)NH(CH 2 ) 2 -O-(CH 2 ) 2 -, ##-CH 2 NHC(O)CH 2 -, ##-(CH 2 ) 2 NHC(O)(CH 2 ) 2 -, ##-(CH 2 ) 2 NHC(O)(CH 2 ) 3 -, ##-(CH 2 ) 2 NHC(O)(CH 2 ) 4 -, ##-(CH 2 ) 2 NHC(O)(CH 2 ) 5 -, ##-(CH 2 ) 3 NHC(O)(CH 2 ) 3 -, ##-(CH 2 ) 3 NHC(O)(CH 2 ) 4 -, ##-(CH 2 ) 4 NHC(O)(CH 2 ) 4 -, ##-(CH 2 ) 5 NHC(O)(CH 2 ) 5 -, ##-(CH 2 ) 6 NHC(O)(CH 2 ) 7 -, ##-(CH 2 ) 6 NHC(O)(CH 2 ) 6 -, ##-(CH 2 ) 7 NHC(O)(CH 2 ) 7 -, ##-(CH 2 ) 8 NHC(O)(CH 2 ) 8 , ##-(CH 2 ) 9 NHC(O)(CH 2 ) 9 -, ##-(CH 2 ) 10 NHC(O)(CH 2 ) 10 -, ##-(CH 2 ) 4 NHC(O)(CH 2 ) 8 -, ##-(CH 2 ) 2 NHC(O)(CH 2 ) 2 -O-(CH 2 ) 2 -, ##-(CH 2 ) 4 NHC(O)CH 2 -, ##-CH 2 -piperidinylene-CH 2 -, ##-CH 2 -piperidinylene-(CH 2 ) 2 -, ##-CH 2 -piperidinylene-(CH 2 ) 3 -, ##-CH 2 -piperidinylene-(CH 2 ) 4 -, ##-CH 2 -piperidinylene-(CH 2 )s-, ##-CH 2 -piperidinylene-(CH 2 ) 6 -, ##-CH 2 -piperidinylene-(CH 2 ) 7 -, ##-CH 2 -piperidinylene-(CH 2 ) 8 -, ##-(CH 2 ) 2 -piperidinylene-(CH 2 ) 1 -, ##-(CH 2 ) 2 -piperidinylene-(CH 2 ) 2 -, ##-(CH 2 ) 2 -piperidinylene-(CH 2 ) 3 -, ##-(CH 2 ) 2 -piperidinylene-(CH 2 ) 4 -, ##-(CH 2 ) 2 -piperidinylene-(CH 2 )s-, ##-(CH 2 ) 2 -piperidinylene-(CH 2 ) 6 -, ##-(CH 2 ) 2 -piperidinylene-(CH 2 ) 7 -, ##-(CH 2 ) 2 -piperidinylene-(CH 2 ) 8 -, ##-(CH 2 ) 3 -piperidinylene-CH 2 -, ##-(CH 2 ) 3 -piperidinylene-(CH 2 ) 2 -, ##-(CH 2 ) 3 -piperidinylene-(CH 2 ) 3 -, ##-(CH 2 ) 3 -piperidinylene-(CH 2 ) 4 -, ##-(CH 2 ) 3 -piperidinylene-(CH 2 ) 5 -, ##-(CH 2 ) 3 -piperidinylene-(CH 2 ) 6 -, ##-(CH 2 ) 3 -piperidinylene-(CH 2 ) 7 -, ##-(CH 2 ) 3 -piperidinylene-(CH 2 ) 8 -, ##-(CH 2 ) 4 -piperidinylene-CH 2 -, ##-(CH 2 ) 4 -piperidinylene-(CH 2 ) 2 -, ##-(CH 2 ) 4 -piperidinylene-(CH 2 ) 3 -, ##-(CH 2 ) 4 -piperidinylene-(CH 2 ) 4 -, ##-(CH 2 ) 4 -piperidinylene-(CH 2 ) 5 -, ##-(CH 2 ) 4 -piperidinylene-(CH 2 ) 6 -, ##-(CH 2 ) 4 -piperidinylene-(CH 2 ) 7 -, ##-(CH 2 ) 4 -pipendinylene-(CH 2 ) 8 -, ##-(CH 2 ) 5 -piperidinylene-(CH 2 ) 1 -, ##-(CH 2 ) 5 -piperidinylene-(CH 2 ) 2 -, ##-(CH 2 ) 5 -piperidinylene-(CH 2 ) 3 -, ##-(CH 2 ) 5 -piperidinylene-(CH 2 ) 4 -, ##-(CH 2 ) 5 -piperidinylene-(CH 2 ) 5 -, ##-(CH 2 ) 5 -piperidinylene-(CH 2 ) 6 -, ##-(CH 2 ) 5 -piperidinylene-(CH 2 ) 7 -, ##-(CH 2 ) 5 -piperidinylene-(CH 2 ) 8 -, ##-(CH 2 ) 6 -piperidinylene-(CH 2 ) 1 -, ##-(CH 2 ) 6 -piperidinylene-(CH 2 ) 2 -, ##-(CH 2 ) 6 -piperidinylene-(CH 2 ) 3 -, ##-(CH 2 ) 6 -piperidinylene-(CH 2 ) 4 -, ##-(CH 2 ) 6 -piperidinylene-(CH 2 ) 5 -, ##-(CH 2 ) 6 -piperidinylene-(CH 2 ) 6 -, ##-(CH 2 ) 6 -piperidinylene-(CH 2 ) 7 -, ##-(CH 2 ) 6 -piperidinylene-(CH 2 ) 8 -, ##-(CH 2 ) 7 -piperidinylene-(CH 2 ) 1 -, ##-(CH 2 ) 7 -piperidinylene-(CH 2 ) 2 -, ##-(CH 2 ) 7 -piperidinylene-(CH 2 ) 3 -, ##-(CH 2 ) 7 -piperidinylene-(CH 2 ) 4 -, ##-(CH 2 ) 7 -pipendinylene-(CH 2 ) 8 -, ##-(CH 2 ) 8 -piperidinylene-CH 2 -, ##-(CH 2 ) 8 -piperidinylene-(CH 2 ) 2 -, ##-(CH 2 ) 8 -piperidinylene-(CH 2 ) 3 -, ##-(CH 2 ) 8 -piperidinylene-(CH 2 ) 4 -, ##-(CH 2 ) 8 -piperidinylene-(CH 2 ) 5 -, ##-(CH 2 ) 8 -piperidinylene-(CH 2 ) 6 -, ##-(CH 2 ) 8 -piperidinylene-(CH 2 ) 7 -, ##-(CH 2 ) 8 -piperidinylene-(CH 2 ) 8 -, ##-CH 2 -piperazinylene-CH 2 -, ##-CH 2 -piperazinylene-(CH 2 ) 2 -, ##-CH 2 -piperazinylene-(CH 2 ) 3 -, ##-CH 2 -piperazinylene-(CH 2 ) 4 -, ##-CH 2 -piperazinylene-(CH 2 ) 5 -, ##-CH 2 -piperazinylene-(CH 2 ) 6 -, ##-CH 2 -piperazinylene-(CH 2 ) 7 -, ##-CH 2 -piperazinylene-(CH 2 ) 8 -, ##-(CH 2 ) 2 -piperazinylene-(CH 2 ) 1 -, ##-(CH 2 ) 2 -piperazinylene-(CH 2 ) 2 -, ##-(CH 2 ) 2 -piperazinylene-(CH 2 ) 3 -, ##-(CH 2 ) 2 -piperazinylene-(CH 2 ) 4 -, ##-(CH 2 ) 2 -piperazinylene-(CH 2 ) 5 -, ##-(CH 2 ) 2 -piperazinylene-(CH 2 ) 6 -, ##-(CH 2 ) 2 -piperazinylene-(CH 2 ) 7 -, ##-(CH 2 ) 2 -piperazinylene-(CH 2 ) 8 -, ##-(CH 2 ) 3 -piperazinylene-CH 2 -, ##-(CH 2 ) 3 -piperazinylene-(CH 2 ) 2 -, ##-(CH 2 ) 3 -piperazinylene-(CH 2 ) 3 -, ##-(CH 2 ) 3 -piperazinylene-(CH 2 ) 4 -, ##-(CH 2 ) 3 -piperazinylene-(CH 2 ) 5 -, ##-(CH 2 ) 3 -piperazinylene-(CH 2 ) 6 -, ##-(CH 2 ) 3 -piperazinylene-(CH 2 ) 7 -, ##-(CH 2 ) 3 -piperazinylene-(CH 2 ) 8 -, ##-(CH 2 ) 4 -piperazinylene-CH 2 -, ##-(CH 2 ) 4 -piperazinylene-(CH 2 ) 2 -, ##-(CH 2 ) 4 -piperazinylene-(CH 2 ) 3 -, ##-(CH 2 ) 4 -piperazinylene-(CH 2 ) 4 -, ##-(CH 2 ) 4 -piperazinylene-(CH 2 ) 5 -, ##-(CH 2 ) 4 -piperazinylene-(CH 2 ) 6 -, ##-(CH 2 ) 4 -piperazinylene-(CH 2 ) 7 -, ##-(CH 2 ) 4 -piperazinylene-(CH 2 ) 8 -, ##-(CH 2 ) 5 -piperazinylene-(CH 2 ) 1 -, ##-(CH 2 ) 5 -piperazinylene-(CH 2 ) 2 -, ##-(CH 2 ) 5 -piperazinylene-(CH 2 ) 3 -, ##-(CH 2 ) 5 -piperazinylene-(CH 2 ) 4 -, ##-(CH 2 ) 5 -piperazinylene-(CH 2 ) 5 -, ##-(CH 2 ) 5 -piperazinylene-(CH 2 ) 6 -, ##-(CH 2 ) 5 -piperazinylene-(CH 2 ) 7 -, ##-(CH 2 ) 5 -piperazinylene-(CH 2 ) 8 -, ##-(CH 2 ) 6 -piperazinylene-(CH 2 ) 1 -, ##-(CH 2 ) 6 -piperazinylene-(CH 2 ) 2 -, ##-(CH 2 ) 6 -piperazinylene-(CH 2 ) 3 -, ##-(CH 2 ) 6 -piperazinylene-(CH 2 ) 4 -, ##-(CH 2 ) 6 -piperazinylene-(CH 2 ) 5 -, ##-(CH 2 ) 6 -piperazinylene-(CH 2 ) 6 -, ##-(CH 2 ) 6 -piperazinylene-(CH 2 ) 7 -, ##-(CH 2 ) 6 -piperazinylene-(CH 2 ) 8 -, ##-(CH 2 ) 7 -piperazinylene-(CH 2 ) 1 -, ##-(CH 2 ) 7 -piperazinylene-(CH 2 ) 2 -, ##-(CH 2 ) 7 -piperazinylene-(CH 2 ) 3 -, ##-(CH 2 ) 7 -piperazinylene-(CH 2 ) 4 -, ##-(CH 2 ) 7 -piperazinylene-(CH 2 ) 8 -, ##-(CH 2 ) 8 -piperazinylene-CH 2 -, ##-(CH 2 ) 8 -piperazinylene-(CH 2 ) 2 -, ##-(CH 2 ) 8 -piperazinylene-(CH 2 ) 3 -, ##-(CH 2 ) 8 -piperazinylene-(CH 2 ) 4 -, ##-(CH 2 ) 8 -piperazinylene-(CH 2 ) 5 -, ##-(CH 2 ) 8 -piperazinylene-(CH 2 ) 6 -, ##-(CH 2 ) 8 -piperazinylene-(CH 2 ) 7 -, ##-(CH 2 ) 8 -piperazinylene-(CH 2 ) 8 -, ##-CH 2 -propylene-CH 2 -, ##-CH 2 -propylene-(CH 2 ) 2 -, ##-CH 2 -propylene-(CH 2 ) 3 -, ##-CH 2 -propylene-(CH 2 ) 4 -, ##-CH 2 -propylene-(CH 2 ) 5 -, ##-CH 2 -propylene-(CH 2 ) 6 -, ##-CH 2 -propylene-(CH 2 ) 7 -, ##-CH 2 -propylene-(CH 2 ) 8 -, ##-(CH 2 ) 2 -propylene-(CH 2 ) 1 -, ##-(CH 2 ) 2 -propylene-(CH 2 ) 2 -, ##-(CH 2 ) 2 -propylene-(CH 2 ) 3 -, ##-(CH 2 ) 2 -propylene-(CH 2 ) 4 -, ##-(CH 2 ) 2 -propylene-(CH 2 ) 5 -, ##-(CH 2 ) 2 -propylene-(CH 2 ) 6 -, ##-(CH 2 ) 2 -propylene-(CH 2 ) 7 -, ##-(CH 2 ) 2 -propylene-(CH 2 ) 8 -, ##-(CH 2 ) 3 -propylene-CH 2 -, ##-(CH 2 ) 3 -propylene-(CH 2 ) 2 -, ##-(CH 2 ) 3 -propylene-(CH 2 ) 3 -, ##-(CH 2 ) 3 -propylene-(CH 2 ) 4 -, ##-(CH 2 ) 3 -propylene-(CH 2 ) 5 -, ##-(CH 2 ) 3 -propylene-(CH 2 ) 6 -, ##-(CH 2 ) 3 -propylene-(CH 2 ) 7 -, ##-(CH 2 ) 3 -propylene-(CH 2 ) 8 -, ##-(CH 2 ) 4 -propylene-CH 2 -, ##-(CH 2 ) 4 -propylene-(CH 2 ) 2 -, ##-(CH 2 ) 4 -propylene-(CH 2 ) 3 -, ##-(CH 2 ) 4 -propylene-(CH 2 ) 4 -, ##-(CH 2 ) 4 -propylene-(CH 2 ) 5 -, ##-(CH 2 ) 4 -propylene-(CH 2 ) 6 -, ##-(CH 2 ) 4 -propylene-(CH 2 ) 7 -, ##-(CH 2 ) 4 -propylene-(CH 2 ) 8 -, ##-(CH 2 ) 5 -propylene-(CH 2 ) 1 -, ##-(CH 2 ) 5 -propylene-(CH 2 ) 2 -, ##-(CH 2 ) 5 -propylene-(CH 2 ) 3 -, ##-(CH 2 ) 5 -propylene-(CH 2 ) 4 -, ##-(CH 2 ) 5 -propylene-(CH 2 ) 5 -, ##-(CH 2 ) 5 -propylene-(CH 2 ) 6 -, ##-(CH 2 ) 5 -propylene-(CH 2 ) 7 -, ##-(CH 2 ) 5 -propylene-(CH 2 ) 8 -, ##-(CH 2 ) 6 -propylene-(CH 2 ) 1 -, ##-(CH 2 ) 6 -propylene-(CH 2 ) 2 -, ##-(CH 2 ) 6 -propylene-(CH 2 ) 3 -, ##-(CH 2 ) 6 -propylene-(CH 2 ) 4 -, ##-(CH 2 ) 6 -propylene-(CH 2 ) 5 -, ##-(CH 2 ) 6 -propylene-(CH 2 ) 6 -, ##-(CH 2 ) 6 -propylene-(CH 2 ) 7 -, ##-(CH 2 ) 6 -propylene-(CH 2 ) 8 -, ##-(CH 2 ) 7 -propylene-(CH 2 ) 1 -, ##-(CH 2 ) 7 -propylene-(CH 2 ) 2 -, ##-(CH 2 ) 7 -propylene-(CH 2 ) 3 -, ##-(CH 2 ) 7 -propylene-(CH 2 ) 4 -, ##-(CH 2 ) 7 -propylene-(CH 2 ) 8 -, ##-(CH 2 ) 8 -propylene-CH 2 -, ##-(CH 2 ) 8 -propylene-(CH 2 ) 2 -, ##-(CH 2 ) 8 -propylene-(CH 2 ) 3 -, ##-(CH 2 ) 8 -propylene-(CH 2 ) 4 -, ##-(CH 2 ) 8 -propylene-(CH 2 ) 5 -, ##-(CH 2 ) 8 -propylene-(CH 2 ) 6 -, ##-(CH 2 ) 8 -propylene-(CH 2 ) 7 -, ##-(CH 2 ) 8 -propylene-(CH 2 ) 8 -, ##-CH 2 -diazacycloheptanylene-CH 2 -, ##-CH 2 -diazacycloheptanylene-(CH 2 ) 2 -, ##-CH 2 -diazacycloheptanylene-(CH 2 ) 3 -, ##-CH 2 -diazacycloheptanylene-(CH 2 ) 4 -, ##-CH 2 -diazacycloheptanylene-(CH 2 ) 5 -, ##-CH 2 -diazacycloheptanylene-(CH 2 ) 6 -, ##-CH 2 -diazacycloheptanylene-(CH 2 ) 7 -, ##-CH 2 -diazacycloheptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 2 -diazacycloheptanylene-(CH 2 ) 1 -, ##-(CH 2 ) 2 -diazacycloheptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 2 -diazacycloheptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 2 -diazacycloheptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 2 -diazacycloheptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 2 -diazacycloheptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 2 -diazacycloheptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 2 -diazacycloheptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 3 -diazacycloheptanylene-CH 2 -, ##-(CH 2 ) 3 -diazacycloheptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 3 -diazacycloheptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 3 -diazacycloheptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 3 -diazacycloheptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 3 -diazacycloheptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 3 -diazacycloheptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 3 -diazacycloheptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 4 -diazacycloheptanylene-CH 2 -, ##-(CH 2 ) 4 -diazacycloheptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 4 -diazacycloheptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 4 -diazacycloheptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 4 -diazacycloheptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 4 -diazacycloheptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 4 -diazacycloheptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 4 -diazacycloheptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 5 -diazacycloheptanylene-(CH 2 ) 1 -, ##-(CH 2 ) 5 -diazacycloheptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 5 -diazacycloheptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 5 -diazacycloheptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 5 -diazacycloheptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 5 -diazacycloheptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 5 -diazacycloheptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 5 -diazacycloheptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 6 -diazacycloheptanylene-(CH 2 ) 1 -, ##-(CH 2 ) 6 -diazacycloheptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 6 -diazacycloheptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 6 -diazacycloheptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 6 -diazacycloheptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 6 -diazacycloheptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 6 -diazacycloheptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 6 -diazacycloheptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 7 -diazacycloheptanylene-(CH 2 ) 1 -, ##-(CH 2 ) 7 -diazacycloheptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 7 -diazacycloheptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 7 -diazacycloheptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 7 -diazacycloheptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 8 -diazacycloheptanylene-CH 2 -, ##-(CH 2 ) 8 -diazacycloheptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 8 -diazacycloheptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 8 -diazacycloheptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 8 -diazacycloheptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 8 -diazacycloheptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 8 -diazacycloheptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 8 -diazacycloheptanylene-(CH 2 ) 8 -, ##-CH 2 -diazabicyclo[2.2.1]heptanylene-CH 2 -, ##-CH 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 2 -, ##-CH 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 3 -, ##-CH 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 4 -, ##-CH 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 5 -, ##-CH 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 6 -, ##-CH 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 7 -, ##-CH 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 1 -, ##-(CH 2 ) 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 2 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 3 -diazabicyclo[2.2.1]heptanylene-CH 2 -, ##-(CH 2 ) 3 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 3 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 3 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 3 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 3 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 3 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 3 -diazabicyclo[2.2.1]heptanylene-(CH Z ) s -, ##-(CH 2 ) 4 -diazabicyclo[2.2.1]heptanylene-CH 2 -, ##-(CH 2 ) 4 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 4 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 4 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 4 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 4 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 4 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 4 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 5 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 1 -, ##-(CH 2 ) 5 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 5 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 5 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 5 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 5 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 5 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 5 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 6 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 1 -, ##-(CH 2 ) 6 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 6 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 6 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 6 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 6 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 6 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 6 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 7 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 1 -, ##-(CH 2 ) 7 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 7 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 7 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 7 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 8 -diazabicyclo[2.2.1]heptanylene-CH 2 -, ##-(CH 2 ) 8 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 8 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 8 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 8 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 8 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 8 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 8 -diazabicyclo[2.2.1]heptanylene-(CH 2 ) 8 -, ##-CH 2 -diazabicyclo[3.1.1]heptanylene-CH 2 -, ##-CH 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 2 -, ##-CH 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 3 -, ##-CH 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 4 -, ##-CH 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 5 -, ##-CH 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 6 -, ##-CH 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 7 -, ##-CH 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 1 -, ##-(CH 2 ) 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 2 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 3 -diazabicyclo[3.1.1]heptanylene-CH 2 -, ##-(CH 2 ) 3 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 3 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 3 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 3 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 3 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 3 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 3 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 4 -diazabicyclo[3.1.1]heptanylene-CH 2 -, ##-(CH 2 ) 4 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 4 -diazabicyclo[3 .1.1]heptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 4 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 4 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 4 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 4 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 4 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 5 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 1 -, ##-(CH 2 ) 5 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 5 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 5 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 5 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 5 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 5 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 5 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 6 -diazabicyclo[3 .1.1]heptanylene-(CH 2 ) 1 -, ##-(CH 2 ) 6 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 6 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 6 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 6 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 6 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 6 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 6 -diazabicyclo[3 .1.1]heptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 7 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 1 -, ##-(CH 2 ) 7 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 7 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 7 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 7 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 8 -, ##-(CH 2 ) 5 -diazabicyclo[3.1.1]heptanylene-CH 2 -, ##-(CH 2 ) 5 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 2 -, ##-(CH 2 ) 5 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 3 -, ##-(CH 2 ) 8 -diazabicyclo[3 .1.1]heptanylene-(CH 2 ) 4 -, ##-(CH 2 ) 8 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 5 -, ##-(CH 2 ) 5 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 6 -, ##-(CH 2 ) 8 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 7 -, ##-(CH 2 ) 8 -diazabicyclo[3.1.1]heptanylene-(CH 2 ) 8 -, ##-CH 2 -diazabicyclo[3.2.1]octylene-CH 2 -, ##-CH 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 2 -, ##-CH 2 -diazabicyclo[3.2. 1]octylene-(CH 2 ) 3 -, ##-CH 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 4 -, ##-CH 2 -diazabicyclo[3.2. 1]octylene-(CH 2 ) 5 -, ##-CH 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 6 -, ##-CH 2 -diazabicyclo[3.2. 1]octylene-(CH 2 ) 7 -, ##-CH 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 8 -, ##-(CH 2 ) 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 1 -, ##-(CH 2 ) 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 2 -, ##-(CH 2 ) 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 3 -, ##-(CH 2 ) 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 4 -, ##-(CH 2 ) 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 5 -, ##-(CH 2 ) 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 6 -, ##-(CH 2 ) 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 7 -, ##-(CH 2 ) 2 -diazabicyclo[3.2.1]octylene-(CH 2 ) 8 -, ##-(CH 2 ) 3 -diazabicyclo[3.2. 1]octylene-CH 2 -, ##-(CH 2 ) 3 -diazabicyclo[3.2.1]octylene-(CH 2 ) 2 -, ##-(CH 2 ) 3 -diazabicyclo[3.2.1]octylene-(CH 2 ) 3 -, ##-(CH 2 ) 3 -diazabicyclo[3.2.1]octylene-(CH 2 ) 4 -, ##-(CH 2 ) 3 -diazabicyclo[3.2. 1]octylene-(CH 2 ) 5 -, ##-(CH 2 ) 3 -diazabicyclo[3.2.1]octylene-(CH 2 ) 6 -, ##-(CH 2 ) 3 -diazabicyclo[3.2.1]octylene-(CH 2 ) 7 -, ##-(CH 2 ) 3 -diazabicyclo[3.2.1]octylene-(CH 2 ) 8 -, ##-(CH 2 ) 4 -diazabicyclo[3.2. 1]octylene-CH 2 -, ##-(CH 2 ) 4 -diazabicyclo[3.2.1]octylene-(CH 2 ) 2 -, ##-(CH 2 ) 4 -diazabicyclo[3.2.1]octylene-(CH 2 ) 3 -, ##-(CH 2 ) 4 -diazabicyclo[3.2.1]octylene-(CH 2 ) 4 -, ##-(CH 2 ) 4 -diazabicyclo[3.2.1]octylene-(CH 2 ) 5 -, ##-(CH 2 ) 4 -diazabicyclo[3.2.1]octylene-(CH 2 ) 6 -, ##-(CH 2 ) 4 -diazabicyclo[3.2.1]octylene-(CH 2 ) 7 -, ##-(CH 2 ) 4 -diazabicyclo[3.2.1]octylene-(CH 2 ) 8 -, ##-(CH 2 ) 5 -diazabicyclo[3.2.1]octylene-(CH 2 ) 1 -, ##-(CH 2 ) 5 -diazabicyclo[3.2.1]octylene-(CH 2 ) 2 -, ##-(CH 2 ) 5 -diazabicyclo[3.2.l]octylene-(CH 2 ) 3 -, ##-(CH 2 ) 5 -diazabicyclo[3.2.1]octylene-(CH 2 ) 4 -, ##-(CH 2 ) 5 -diazabicyclo[3.2. 1]octylene-(CH 2 ) 5 -, ##-(CH 2 ) 5 -diazabicyclo[3.2.1]octylene-(CH 2 ) 6 -, ##-(CH 2 ) 5 -diazabicyclo[3.2.1]octylene-(CH 2 ) 7 -, ##-(CH 2 ) 5 -diazabicyclo[3.2.1]octylene-(CH 2 ) 8 -, ##-(CH 2 ) 6 -diazabicyclo[3.2. 1]octylene-(CH 2 ) 1 -, ##-(CH 2 ) 6 -diazabicyclo[3.2.1]octylene-(CH 2 ) 2 -, ##-(CH 2 ) 6 -diazabicyclo[3.2.1]octylene-(CH 2 ) 3 -, ##-(CH 2 ) 6 -diazabicyclo[3.2.1]octylene-(CH 2 ) 4 -, ##-(CH 2 ) 6 -diazabicyclo[3.2.1]octylene-(CH 2 ) 5 -, ##-(CH 2 ) 6 -diazabicyclo[3.2.1]octylene-(CH 2 ) 6 -, ##-(CH 2 ) 6 -diazabicyclo[3.2.1]octylene-(CH 2 ) 7 -, ##-(CH 2 ) 6 -diazabicyclo[3.2.1]octylene-(CH 2 ) 8 -, ##-(CH 2 ) 7 -diazabicyclo[3.2.1]octylene-(CH 2 ) 1 -, ##-(CH 2 ) 7 -diazabicyclo[3.2.1]octylene-(CH 2 ) 2 -, ##-(CH 2 ) 7 -diazabicyclo[3.2.1]octylene-(CH 2 ) 3 -, ##-(CH 2 ) 7 -diazabicyclo[3.2.1]octylene-(CH 2 ) 4 -, ##-(CH 2 ) 7 -diazabicyclo[3.2. 1]octylene-(CH 2 ) 8 -, ##-(CH 2 ) 8 -diazabicyclo[3.2.1]octylene-CH 2 -, ##-(CH 2 ) 8 -diazabicyclo[3.2.1]octylene-(CH 2 ) 2 -, ##-(CH 2 ) 8 -diazabicyclo[3.2.1]octylene-(CH 2 ) 3 -, ##-(CH 2 ) 8 -diazabicyclo[3.2.1]octylene-(CH 2 ) 4 -, ##-(CH 2 ) 8 -diazabicyclo[3.2.1]octylene-(CH 2 ) 5 -, ##-(CH 2 ) 8 -diazabicyclo[3.2.1]octylene-(CH 2 ) 6 -, ##-(CH 2 ) 8 -diazabicyclo[3.2.1]octylene-(CH 2 ) 7 -, ##-(CH 2 ) 8 -diazabicyclo[3.2.1]octylene-(CH 2 ) 8 -, ##-CH 2 -diazabicyclo[2.2.2]octylene-CH 2 -, ##-CH 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 2 -, ##-CH 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 3 -, ##-CH 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 4 -, ##-CH 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 5 -, ##-CH 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 6 -, ##-CH 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 7 -, ##-CH 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 8 -, ##-(CH 2 ) 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 1 -, ##-(CH 2 ) 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 2 -, ##-(CH 2 ) 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 3 -, ##-(CH 2 ) 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 4 -, ##-(CH 2 ) 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 5 -, ##-(CH 2 ) 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 6 -, ##-(CH 2 ) 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 7 -, ##-(CH 2 ) 2 -diazabicyclo[2.2.2]octylene-(CH 2 ) 8 -, ##-(CH 2 ) 3 -diazabicyclo[2.2.2]octylene-CH 2 -, ##-(CH 2 ) 3 -diazabicyclo[2.2.2]octylene-(CH 2 ) 2 -, ##-(CH 2 ) 3 -diazabicyclo[2.2.2]octylene-(CH 2 ) 3 -, ##-(CH 2 ) 3 -diazabicyclo[2.2.2]octylene-(CH 2 ) 4 -, ##-(CH 2 ) 3 -diazabicyclo[2.2.2]octylene-(CH 2 ) 5 -, ##-(CH 2 ) 3 -diazabicyclo[2.2.2]octylene-(CH 2 ) 6 -, ##-(CH 2 ) 3 -diazabicyclo[2.2.2]octylene-(CH 2 ) 7 -, ##-(CH 2 ) 3 -diazabicyclo[2.2.2]octylene-(CH 2 ) 8 -, ##-(CH 2 ) 4 -diazabicyclo[2.2.2]octylene-CH 2 -, ##-(CH 2 ) 4 -diazabicyclo[2.2.2]octylene-(CH 2 ) 2 -, ##-(CH 2 ) 4 -diazabicyclo[2.2.2]octylene-(CH 2 ) 3 -, ##-(CH 2 ) 4 -diazabicyclo[2.2.2]octylene-(CH 2 ) 4 -, ##-(CH 2 ) 4 -diazabicyclo[2.2.2]octylene-(CH 2 ) 5 -, ##-(CH 2 ) 4 -diazabicyclo[2.2.2]octylene-(CH 2 ) 6 -, ##-(CH 2 ) 4 -diazabicyclo[2.2.2]octylene-(CH 2 ) 7 -, ##-(CH 2 ) 4 -diazabicyclo[2.2.2]octylene-(CH 2 ) 8 -, ##-(CH 2 ) 5 -diazabicyclo[2.2.2]octylene-(CH 2 ) 1 -, ##-(CH 2 ) 5 -diazabicyclo[2.2.2]octylene-(CH 2 ) 2 -, ##-(CH 2 ) 5 -diazabicyclo[2.2.2]octylene-(CH 2 ) 3 -, ##-(CH 2 ) 5 -diazabicyclo[2.2.2]octylene-(CH 2 ) 4 -, ##-(CH 2 ) 5 -diazabicyclo[2.2.2]octylene-(CH 2 ) 5 -, ##-(CH 2 ) 5 -diazabicyclo[2.2.2]octylene-(CH 2 ) 6 -, ##-(CH 2 ) 5 -diazabicyclo[2.2.2]octylene-(CH 2 ) 7 -, ##-(CH 2 ) 5 -diazabicyclo[2.2.2]octylene-(CH 2 ) 8 -, ##-(CH 2 ) 6 -diazabicyclo[2.2.2]octylene-(CH 2 ) 1 -, ##-(CH 2 ) 6 -diazabicyclo[2.2.2]octylene-(CH 2 ) 2 -, ##-(CH 2 ) 6 -diazabicyclo[2.2.2]octylene-(CH 2 ) 3 -, ##-(CH 2 ) 6 -diazabicyclo[2.2.2]octylene-(CH 2 ) 4 -, ##-(CH 2 ) 6 -diazabicyclo[2.2.2]octylene-(CH 2 ) 5 -, ##-(CH 2 ) 6 -diazabicyclo[2.2.2]octylene-(CH 2 ) 6 -, ##-(CH 2 ) 6 -diazabicyclo[2.2.2]octylene-(CH 2 ) 7 -, ##-(CH 2 ) 6 -diazabicyclo[2.2.2]octylene-(CH 2 ) 8 -, ##-(CH 2 ) 7 -diazabicyclo[2.2.2]octylene-(CH 2 ) 1 -, ##-(CH 2 ) 7 -diazabicyclo[2.2.2]octylene-(CH 2 ) 2 -, ##-(CH 2 ) 7 -diazabicyclo[2.2.2]octylene-(CH 2 ) 3 -, ##-(CH 2 ) 7 -diazabicyclo[2.2.2]octylene-(CH 2 ) 4 -, ##-(CH 2 ) 7 -diazabicyclo[2.2.2]octylene-(CH 2 ) 8 -, ##-(CH 2 ) 8 -diazabicyclo[2.2.2]octylene-CH 2 -, ##-(CH 2 ) 8 -diazabicyclo[2.2.2]octylene-(CH 2 ) 2 -, ##-(CH 2 )s-diazabicyclo[2.2.2]octylene-(CH 2 ) 3 -, ##-(CH 2 ) 8 -diazabicyclo[2.2.2]octylene-(CH 2 ) 4 -, ##-(CH 2 ) 8 -diazabicyclo[2.2.2]octylene-(CH 2 ) 5 -, ##-(CH 2 ) 8 -diazabicyclo[2.2.2]octylene-(CH 2 ) 6 -, ##-(CH 2 ) 8 -diazabicyclo[2.2.2]octylene-(CH 2 ) 7 -, or ##-(CH 2 ) 8 -diazabicyclo[2.2.2]octylene-(CH 2 ) 8 -; wherein the propylene, the piperidinylene, the piperazinylene, the diazacycloheptanylene, the diazabicyclo[2.2.1]heptanylene, the diazabicyclo[3.1.1]heptanylene, the diazabicyclo[3.2.1]octylene, the diazabicyclo[2.2.2]octylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C 1-4 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C 1-4 alkoxy, C 1-4 alkyl-NH-, halogenated C 1-4 alkyl, NH 2 -C 1-4 alkylene, C 1-4 alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH- or any combination thereof; each R g10 independently represents H or C 1-3 alkyl; and symbol ## indicates the point of attachment to X 1 .

[0059] In some embodiments of the compound of Formula (I-2), L 1 represents the following group: wherein symbol ## indicates the point of attachment to X 1 .

[0060] In some embodiments of the compound of Formula (I-2), L 1 represents the structure of the following formula: ##-C 1-30 alkylene-, wherein a hydrogen atom of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) CH 2 groups of the C 1-30 alkylene is optionally replaced with a substituent selected from the group consisting of: D, optionally deuterated C 1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, C 1-6 alkoxy or any combination thereof, and symbol ## indicates the point of attachment to X 1 .

[0061] In some embodiments of the compound of Formula (I-2), L 1 represents the following group: ##-CH 2 -, ##-(CH 2 ) 2 -, ##-(CH 2 ) 3 -, ##-(CH 2 ) 4 -, ##-(CH 2 ) 5 -, ##-(CH 2 ) 2 -CF 2 -(CH 2 ) 2 -, ##-(CH 2 ) 6 -, ##-(CH 2 ) 7 -, ##-(CH 2 ) 8 -, ##-(CH 2 ) 9 -, ##-(CH 2 ) 10 -, ##-(CH 2 ) 11 -, ##-(CH 2 ) 12 -, ##-(CH 2 ) 13 -, ##-(CH 2 ) 14 -, ##-(CH 2 ) 15 -, ##-(CH 2 ) 16 -, ##-(CH 2 ) 17 -, ##-(CH 2 ) 18 -, ##-(CH 2 ) 19 -, ##-(CH 2 ) 20 -, ##-(CH 2 ) 21 -, ##-(CH 2 ) 22 -, ##-(CH 2 ) 25 -, or ##-(CH 2 ) 30 -; wherein a hydrogen atom of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) CH 2 of the group is optionally replaced with a substituent selected from the group consisting of: D, optionally deuterated C 1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, C 1-6 alkoxy or any combination thereof, and symbol ## indicates the point of attachment to X 1 .

[0062] In some embodiments of the compound of Formula (I-2), R 1 represents C 1-60 alkyl (e.g., C 1 -C 30 alkyl, C 1 -C 29 alkyl, C 1 -C 2S alkyl, C 1 -C 27 alkyl, C 1 -C 26 alkyl, C 1 -C 25 alkyl, C 1 -C 24 alkyl, C 1 -C 23 alkyl, C 1 -C 22 alkyl, C 1 -C 21 alkyl, C 1 -C 20 alkyl, C 1 -C 19 alkyl, C 1 -C 18 alkyl, C 1 -C 17 alkyl, C 1 -C 16 alkyl, C 1 -C 15 alkyl, C 1 -C 14 alkyl, C 1 -C 13 alkyl, C 1 -C 12 alkyl, C 1 -C 11 alkyl, C 1 -C 10 alkyl, C 1 -C 9 alkyl, C 1 -C 8 alkyl, C 1 -C 7 alkyl, C 1 -C 6 alkyl, C 1 -C 5 alkyl, C 1 -C 4 alkyl, C 1 -C 3 alk...

Claims

1. A compound of Formula (I) or a salt, enantiomer, diastereoisomer, isotopically enriched analog, solvate, prodrug, or polymorph thereof, wherein Rc1 represents H or C1-3 alkyl, Rc2, Rc3, Rc4, Rc5 and Rc6 are the same or different and each independently represent H, D or C1-3 alkyl; (R1a)n indicates that quinazoline ring of Formula (I) is optionally substituted with n R1a, wherein R1a represents halogen, and n represents an integer of 0, 1, 2, or 3; and Ra represents the following formula:         Ra1-X2-L1-X1- , wherein X1 represents optionally substituted cycloalkylene, optionally substituted heterocyclylene, optionally substituted arylene, or optionally substituted heteroarylene; Li represents optionally substituted linear or branched C1-60 alkylene, or optionally substituted linear or branched C2-60 alkylene with one or more groups Rai and / or one or more groups Rd2 and / or any combination of one or more groups Rai and Rd2 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group Rai, Rd2, or a combination of Rd1 and Rd2; wherein each Rai is independently selected from the group consisting of O, S, N(Rd3), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, where Rd3 represents H or C1-3 alkyl, and in case that two or more groups Rai are inserted into the backbone carbon chain of the linear or branched C2-60 alkylene group, the two or more groups Rai are not directly connected to each other; and wherein each Rd2 is independently selected from the group consisting of optionally substituted cycloalkylene, optionally substituted heterocyclylene, optionally substituted arylene, optionally substituted heteroarylene, alkenylene, alkynylene, or any combination thereof; X2 represents a bond; and Ra1 represents NRd4Rd5, C(O)NRd6Rd7, NHC(O)Ras, NHC(O)NRd9Rd10, C(O)ORd11, OC(O)Rd12, ORd13, SRd14, C(O)Rd15, C(S)Rd16, S(O)Rd17, S(O)2Rd18, S(O)2NHRd19, NHS(O)2Rd20, S(O)2ORd21, OS(O)2Rd22, optionally substituted linear or branched C1-10 alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl or optionally substituted heteroaryl, wherein Rd4, Ras, Rd6, Rd7, Rd9, Rd10, Rd11, Rd13, Rd14, Rd19 and Rd21 each independently represent H, optionally substituted linear or branched Ci-io alkyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heterocyclyl or optionally substituted heteroaryl, and Ras, Rd12, Rd15, Rd16, Rd17, Rd18, Rd20 and Rd22 represents optionally substituted linear or branched C1-10 alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl or optionally substituted heteroaryl; or X1 represents N(Re1), O, S, alkynylene, alkenylene, optionally substituted cycloalkylene, optionally substituted heterocyclylene, optionally substituted arylene, or optionally substituted heteroarylene, wherein Re1 represents H or C1-3 alkyl, or X1 represents a bond; L1 represents optionally substituted linear or branched C1-60 alkylene, or optionally substituted linear or branched C2-60 alkylene with one or more groups Re2 and / or one or more groups Re3 and / or any combination of one or more groups Re2 and Re3 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group Re2, Re3, or a combination of Re2 and Re3; wherein each Re2 is independently selected from the group consisting of O, S, N(Re4), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH, or NHS(O)2, wherein Re4 represents H or C1-3 alkyl, and in case that two or more groups Re2 are inserted into the backbone carbon chain of the linear or branched C2-60 alkylene group, the two or more groups Re2 are not directly connected to each other; and wherein each Re3 is independently selected from the group consisting of optionally substituted cycloalkylene, optionally substituted heterocyclylene, optionally substituted arylene, optionally substituted heteroarylene, alkenylene, alkynylene, or any combination thereof; X2 represents C(O), S(O) or S(O)2, or X2 represents a bond; Ra1 represents the following formula: wherein Rf1 represents:         -NCH2CH2N-; wherein symbol * indicates the point of attachment to X2, Rg1 represents H or C1-3 alkyl, ring A represents cycloalkylene or heterocyclylene, and (Rg2)n1 indicates that ring A is optionally substituted with n1 Rg2 groups, wherein n1 represents an integer of 0 to 8, and each Rg2, the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, NH2-C1-6 alkylene or any combination thereof; wherein symbol ** indicates the point of attachment to X2, Rg3 represents H or C1-3 alkyl, ring B represents cycloalkylene or heterocyclylene, (Rg4)n2 indicates that ring B is optionally substituted with n2 Rg4, wherein n2 represents an integer of 0 to 8, and each Rg4, the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, NH2-C1-6 alkylene or any combination thereof; or wherein ring C represents cycloalkylene or heterocyclylene, (Rg5)n3 indicates that ring C is optionally substituted with n3 Rg5 groups, wherein n3 represents an integer of 0 to 8, and each Rg5, the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, NH2-C1-6 alkylene or any combination thereof; Rf2 represents H, halogen, C1-3 alkyl or halogenated C1-3 alkyl; Rf3 represents H, halogen, C1-3 alkyl, halogenated C1-3 alkyl, or wherein ring D represents cycloalkylene, heterocyclylene, arylene or heteroarylene, (Rg6)n4 indicates that ring D is optionally substituted with n4 Rg6 groups, wherein n4 represents an integer of 0 to 8, and each Rg6, the same or different from each other, is independently selected from the group consisting of optionally deuterated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, NH2-C1-6 alkylene or any combination thereof; Rf4 represents wherein symbol *** indicates the point of attachment to Rf5, ring E represents cycloalkylene, heterocyclylene, arylene or heteroarylene, (Rg7)n5 indicates that ring E is optionally substituted with n5 Rg7, wherein n5 represents an integer of 0 to 8, and each Rg7, the same or different from each other, is independently selected from the group consisting of optionally deuterated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, NH2-C1-6 alkylene or any combination thereof; and Rf5 represents H, halogen, C1-3 alkyl, halogenated C1-3 alkyl, or wherein ring F represents cycloalkyl, heterocyclyl, aryl or heteroaryl, (Rg8)n6 indicates that ring F is optionally substituted with n6 Rg8, wherein n6 represents an integer of 0 to 8, and each Rg8, the same or different from each other, is independently selected from the group consisting of optionally deuterated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, NH2-C1-6 alkylene or any combination thereof; or X1 represents N(R1), O, S, alkynylene, or alkenylene, wherein R1 represents H or C1-3 alkyl, or X1 represents a bond; L1 represents optionally substituted linear or branched C1-60 alkylene; X2 represents N(R2), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, OS(O)2, optionally substituted 4- to 8-membered heterocyclylene containing 1 to 2 nitrogen atoms, triazolylene, triazolylene-NH-, -NH-triazolylene, or optionally substituted phenylene, wherein R2 represents H or C1-3 alkyl, or X2 represents a bond; and Ra1 represents hydroxy, optionally substituted adamantanyl, optionally substituted noradamantanyl, optionally substituted cubanyl, optionally substituted spirocycloalkyl, optionally substituted bicyclo[2.2.2]octan-1-yl, optionally substituted bicyclo[2.2.2]octan-2-yl, optionally substituted bornyl, optionally substituted bicyclo[2.2.1]heptanyl, optionally substituted bicyclo[2.2.1]heptenyl, optionally substituted p-menthanyl or optionally substituted m-menthanyl, wherein when Ra1 represents hydroxy, X2 represents a bond; or X1 represents N(R3), O or S, wherein R3 represents H or C1-3 alkyl; L1 represents optionally substituted linear or branched C4-60 alkylene; X2 represents N(R4), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, or OS(O)2, wherein R4 represents H or C1-3 alkyl, or X2 represents a bond; and Ra1 represents optionally substituted heterocyclyl; or X1 represents alkynylene or alkenylene, or X1 represents a bond; L1 represents optionally substituted linear or branched C1-60 alkylene; and X2 represents N(R5), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, or OS(O)2, wherein R5 represents H or C1-3 alkyl, or X2 represents a bond; and Ra1 represents optionally substituted heterocyclyl; or X1 represents N(R6), O, S, alkynylene, or alkenylene, wherein R6 represents H or C1-3 alkyl, or X1 represents a bond; L1 represents optionally substituted linear or branched C2-60 alkylene with one or more groups R7 and / or one or more groups R8 and / or any combination of one or more groups R7 and R8 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R7, R8, or a combination of R7 and R8; wherein each R7 is independently selected from the group consisting of O, S, N(R9), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, wherein R9 represents H or C1-3 alkyl, and in case that two or more groups R7 are inserted into the backbone carbon chain of the linear or branched C2-60 alkylene group, the two or more groups R7 are not directly connected to each other; and wherein each R8 is independently selected from the group consisting of cycloalkylene, heterocyclylene, triazolylene, alkenylene, alkynylene or any combination thereof, wherein the cycloalkylene, heterocyclylene and triazolylene are each independently optionally substituted with a substituent selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, cyano or any combination thereof; X2 represents N(R10), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, OS(O)2, optionally substituted 4- to 8-membered heterocyclylene containing 1 to 2 nitrogen atoms, triazolylene, triazolylene-NH-, -NH-triazolylene, or optionally substituted phenylene, wherein R10 represents H or C1-3 alkyl, or X2 represents a bond; and Ra1 represents hydroxy, optionally substituted heterocyclyl or optionally substituted cycloalkyl, wherein when Ra1 represents hydroxy, X2 represents a bond; or Ra represents the following formula:         Ra2-X3-, wherein X3 represents N(R11), C(O)O, OC(O), C(O)NH, NHC(O), O, S, optionally substituted cycloalkylene, optionally substituted arylene, optionally substituted heteroarylene or optionally substituted heterocyclylene, wherein R11 represents H or C1-3 alkyl, and Ra2 represents optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heteroaryl or optionally substituted aryl; and Rb represents C1-60 alkyl optionally substituted with D or halogen, or Rb represents the following formula:         Rb1-X4-L2-, wherein L2 represents optionally substituted linear or branched C2-60 alkylene, or optionally substituted linear or branched C2-60 alkylene with one or more groups R12 and / or one or more groups R13 and / or any combination of one or more groups R12 and R13 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R12, R13, or a combination of R12 and R13; wherein each R12 is independently selected from the group consisting of O, S, N(R14), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, wherein R14 independently represents H or C1-3 alkyl, and in case that two or more groups R12 are inserted into the backbone carbon chain of the linear or branched C2-60 alkylene group, the two or more groups R12 are not directly connected to each other; and wherein each R13 is independently selected from the group consisting of cycloalkylene, heterocyclylene, arylene, heteroarylene, alkenylene, alkynylene or any combination thereof, wherein the cycloalkylene, heterocyclylene, arylene and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, cyano or any combination thereof; X4 represents N(R15), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, OS(O)2, optionally substituted cycloalkylene, optionally substituted arylene, optionally substituted heterocyclylene, optionally substituted heteroarylene, triazolylene-NH-, or -NH-triazolylene, wherein R15 represents H or C1-3 alkyl, or X4 represents a bond; and Rb1 represents optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heterocyclyl or optionally substituted heteroaryl; or Ra represents halogen or cyano, and Rb represents the following formula:         Rb2-X5-L3-, wherein L3 represents optionally substituted linear or branched C2-60 alkylene, or optionally substituted linear or branched C2-60 alkylene with one or more groups R16 and / or one or more groups R17 and / or any combination of one or more groups R16 and R17 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R16, R17, or a combination of R16 and R17; wherein each R16 is independently selected from the group consisting of O, S, N(R18), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, wherein R18 represents H or C1-3 alkyl, and in case that two or more groups R16 are inserted into the backbone carbon chain of the linear or branched C2-60 alkylene group, the two or more groups R16 are not directly connected to each other; and wherein each R17 is independently selected from the group consisting of cycloalkylene, heterocyclylene, arylene, heteroarylene, alkenylene, alkynylene or any combination thereof, wherein the cycloalkylene, heterocyclylene, arylene and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, cyano or any combination thereof; X5 represents N(R19), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, or OS(O)2, wherein R19 represents H or C1-3 alkyl, or X5 represents a bond; and Rb2 represents optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heterocyclyl or optionally substituted heteroaryl, or represents the following formula: wherein Rf1, Rf2, Rf3, Rf4 and Rf5 are defined as above.

2. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 1, wherein the compound of Formula (I) is also of Formula (II) or Formula (III): wherein groups Rc1, Rc2, Rc3, Rc4, Rc5, Rc6, Ra, (R1a)n and Rb are as defined in claim 1.

3. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 1, wherein the compound of Formula (I) is also of Formula (Ia), Formula (Ib), Formula (Ic), Formula (Id), Formula (IIa), Formula (IIb), Formula (IIc), Formula (IId), Formula (IIIa), Formula (IIIb), Formula (IIIc), or Formula (IIId): wherein groups Rc1, Rc2, Rc3, Rc4, Rc5, Rc6, Ra, (R1a)n and Rb are as defined in claim 1.

4. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in any one of claims 1-3, wherein Ra represents the following formula:         Ra1-X2-L1-X1-, wherein X1 represents optionally substituted C3-20 cycloalkylene, optionally substituted 4- to 20-membered nitrogen-containing heterocyclylene, optionally substituted C6-10 arylene, or optionally substituted 5- to 20-membered heteroarylene; L1 represents optionally substituted linear or branched C1-60 alkylene, or optionally substituted linear or branched C2-60 alkylene with one or more groups Rai and / or one or more groups Rd2 and / or any combination of one or more groups Rai and Rd2 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group Rai, Rd2, or a combination of Rd1 and Rd2; wherein each Rai is independently selected from the group consisting of O, S, N(Rd3), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, wherein Rd3 independently represents H or C1-3 alkyl, and in case that two or more groups Rai are inserted into the backbone carbon chain of the linear or branched C2-60 alkylene group, the two or more groups Rai are not directly connected to each other; and wherein each Rd2 is independently selected from the group consisting of optionally substituted C3-15 cycloalkylene, optionally substituted 4- to 15-membered heterocyclylene, optionally substituted C6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C2-6 alkenylene, C2-6 alkynylene or any combination thereof, wherein the C3-15cycloalkylene, the C6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH- or any combination thereof, wherein the linear or branched C1-60 alkylene and the linear or branched C2-60 alkylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, or any combination thereof; X2 represents a bond; and Ra1 represents NRd4Rd5, C(O)NRd6Rd7, NHC(O)Ras, NHC(O)NRd9Rd10, C(O)ORd11, OC(O)Rd12, ORd13, SRd14, C(O)Rd15, C(S)Rd16, S(O)Rd17, S(O)2Rd18, S(O)2NHRd19, NHS(O)2Rd20, S(O)2ORd21, OS(O)2Rd22, optionally substituted linear or branched C1-10 alkyl, optionally substituted C3-20cycloalkyl, optionally substituted 4- to 20-membered heterocyclyl, optionally substituted C6-20 aryl or optionally substituted 5- to 20-membered heteroaryl, wherein Rd4, Rd5, Rd6, Rd7, Rd9, Rd10, Rd11, Rd13, Rd14, Rd19 and Rd21 are the same or different and each independently represent H, optionally substituted linear or branched C1-10 alkyl, optionally substituted C3-20cycloalkyl, optionally substituted C6-20 aryl, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted 5- to 20-membered heteroaryl, and Ras, Rd12, Rd15, Rd16, Rd17, Rd18, Rd20 and Rd22 each independently represent optionally substituted linear or branched C1-10 alkyl, optionally substituted C3-20cycloalkyl, optionally substituted 4- to 20-membered heterocyclyl, optionally substituted C6-20 aryl or optionally substituted 5- to 20-membered heteroaryl; and Rb represents C1-60 alkyl optionally substituted with D or halogen, or Rb represents the following formula:         Rb1-X4-L2- , wherein L2 represents: linear or branched C2-60 alkylene optionally substituted with one or more substituents selected from the group consisting of D, C1-4 alkyl, halogen, C3-6cycloalkyl or any combination thereof, or optionally substituted linear or branched C2-60 alkylene with one or more groups R12 and / or one or more groups R13 and / or any combination of one or more groups R12 and R13 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adj acent carbon atoms in the backbone carbon chain is interrupted by the group R12, R13, or a combination of R12 and R13; wherein each R12 is independently selected from the group consisting of O, S, N(R14), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, wherein R14 independently represents H or C1-3 alkyl, and in case that two or more groups R12 are inserted into the backbone carbon chain of the linear or branched C2-60 alkylene group, the two or more groups R12 are not directly connected to each other; and wherein each R13 is independently selected from the group consisting of C3-15 cycloalkylene, 4- to 15-membered heterocyclylene, C6-10 arylene, 5- to 15-membered heteroarylene, C2-6 alkenylene, C2-6 alkynylene or any combination thereof, wherein the C3-15 cycloalkylene, the 4- to 15-membered heterocyclylene, C6-10 arylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, cyano or any combination thereof, and the linear or branched C2-60 alkylene is optionally substituted with one or more substituents selected from the group consisting of D, C1-4 alkyl, halogen, C3-6 cycloalkyl or any combination thereof; X4 represents a bond, or X4 represents N(R15), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, OS(O)2, optionally substituted C3-20 cycloalkylene, optionally substituted C6-20 arylene, optionally substituted 4- to 20-membered heterocyclylene, optionally substituted 5- to 20-membered heteroarylene, triazolylene-NH-, or -NH-triazolylene, wherein R15 represents H or C1-3 alkyl, and the C3-20 cycloalkylene, the C6-20 arylene, the 4- to 20-membered heterocyclylene, and the 5- to 20-membered heteroarylene are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; and Rb1 represents optionally substituted C3-20 cycloalkyl, optionally substituted C6-20 aryl, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted 5- to 20-membered heteroaryl, wherein the C3-20 cycloalkyl, the C6-20 aryl, the 4- to 20-membered heterocyclyl, and the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof, and wherein the C3-15 cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof.

5. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in any one of claims 1-3, wherein Ra represents the following formula:         Ra1-X2-L1-X1- , wherein X1 represents N(Re1), O, S, C2-6 alkynylene, C2-6 alkenylene, optionally substituted C3-20 cycloalkylene, optionally substituted 4- to 20-membered heterocyclylene, optionally substituted C6-15 arylene, or optionally substituted 5- to 20-membered heteroarylene, wherein Re1 represents H or C1-3 alkyl, or X1 represents a bond; L1 represents optionally substituted linear or branched C1-60 alkylene, or optionally substituted linear or branched C2-60 alkylene with one or more groups Re2 and / or one or more groups Re3 and / or any combination of one or more groups Re2 and Re3 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group Re2, Re3, or a combination of Re2 and Re3; wherein each Re2 is independently selected from the group consisting of O, S, N(Re4), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH, or NHS(O)2, wherein Re4 represents H or C1-3 alkyl, and in case that two or more groups Re2 are inserted into the backbone carbon chain of the linear or branched C2-60 alkylene group, the two or more groups Re2 are not directly connected to each other; and wherein each Re3 is independently selected from the group consisting of optionally substituted C3-15 cycloalkylene, optionally substituted 4- to 15-membered heterocyclylene, optionally substituted C6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C2-6 alkenylene, C2-6 alkynylene or any combination thereof, wherein the linear or branched C1-60 alkylene and the linear or branched C2-60 alkylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, or any combination thereof; X2 represents C(O) or S(O)2, or X2 represents a bond; Ra1 represents the following formula: wherein Rf1 represents:         -NCH2CH2N-; wherein symbol * indicates the point of attachment to X2, Rg1 represents H or C1-3 alkyl, ring A represents C3-20 cycloalkylene or 4- to 20-membered heterocyclylene, (Rg2)n1 indicates that ring A is optionally substituted with n1 Rg2, wherein n1 represents an integer of 0 to 8, and each Rg2, the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, NH2-C1-6 alkylene or any combination thereof; wherein symbol ** indicates the point of attachment to X2, Rg3 represents H or C1-3 alkyl, ring B represents C3-20 cycloalkylene or 4- to 20-membered heterocyclylene, and (Rg4)n2 indicates that ring B is optionally substituted with n2 Rg4, wherein n2 represents an integer of 0 to 8, and each Rg4, the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, NH2-C1-6 alkylene or any combination thereof; or wherein ring C represents C3-20 cycloalkylene or 4- to 20-membered heterocyclylene, (Rg5)n3 indicates that ring C is optionally substituted with n3 Rg5, n3 represents an integer of 0 to 8, and each Rg5, the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, NH2-C1-6 alkylene or any combination thereof; Rf2 represents H, halogen, C1-3 alkyl or halogenated C1-3 alkyl; Rf3 represents H, halogen, C1-3 alkyl, halogenated C1-3 alkyl, or wherein ring D represents C3-20cycloalkylene, 4- to 20-membered heterocyclylene, C6-15 arylene or 5- to 20-membered heteroarylene, (Rg6)n4 indicates that ring D is optionally substituted with n4 Rg6, n4 represents an integer of 0 to 8, and each Rg6, the same or different from each other, is independently selected from the group consisting of optionally deuterated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, NH2-C1-6 alkylene or any combination thereof; Rf4 represents wherein symbol *** indicates the point of attachment to Rf5, ring E represents C3-20 cycloalkylene, 4- to 20-membered heterocyclylene, C6-15 arylene or 5- to 20-membered heteroarylene, (Rg7)n5 indicates that ring E is optionally substituted with n5 Rg7, wherein n5 represents an integer of 0 to 8, and each Rg7, the same or different from each other, is independently selected from the group consisting of optionally deuterated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, NH2-C1-6 alkylene or any combination thereof; and Rf5 represents H, halogen, C1-3 alkyl, halogenated C1-3 alkyl, or wherein ring F represents C3-20 cycloalkyl, 4- to 20-membered heterocyclyl, C6-15 aryl or 5- to 20-membered heteroaryl, (Rg8)n6 indicates that ring F is optionally substituted with n6 Rg8, wherein n6 represents an integer of 0 to 8, and each Rg8, the same or different from each other, is independently selected from the group consisting of optionally deuterated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, NH2-C1-6 alkylene or any combination thereof: and Rb represents C1-60 alkyl optionally substituted with D or halogen, or Rb represents the following formula:         Rb1-X4-L2- , wherein L2 represents linear or branched C2-60 alkylene optionally substituted with one or more substituents selected from the group consisting of D, C1-4 alkyl, halogen, C3-6 cycloalkyl or any combination thereof, or optionally substituted linear or branched C2-60 alkylene with one or more groups R12 and / or one or more groups R13 and / or any combination of one or more groups R12 and R13 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R12, R13, or a combination of R12 and R13; wherein each R12 is independently selected from the group consisting of O, S, N(R14), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, wherein R14 independently represents H or C1-3 alkyl, and in case that two or more groups R12 are inserted into the backbone carbon chain of the linear or branched C2-60 alkylene group, the two or more groups R12 are not directly connected to each other; and wherein each R13 is independently selected from the group consisting of C3-15 cycloalkylene, 4- to 15-membered heterocyclylene, C6-10 arylene, 5- to 15-membered heteroarylene, C2-6 alkenylene, C2-6 alkynylene or any combination thereof, wherein the C3-15 cycloalkylene, the 4- to 15-membered heterocyclylene, C6-10 arylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, cyano or any combination thereof, and the linear or branched C2-60 alkylene is optionally substituted with one or more substituents selected from the group consisting of D, C1-4 alkyl, halogen, C3-6 cycloalkyl or any combination thereof; X4 represents a bond, or X4 represents N(R15), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, OS(O)2, optionally substituted C3-20 cycloalkylene, optionally substituted C6-20 arylene, optionally substituted 4- to 20-membered heterocyclylene, optionally substituted 5- to 20-membered heteroarylene, triazolylene-NH-, or -NH-triazolylene, wherein R15 represents H or C1-3 alkyl, and the C3-20cycloalkylene, the C6-20 arylene, the 4- to 20-membered heterocyclylene, and the 5- to 20-membered heteroarylene are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; and Rb1 represents optionally substituted C3-20 cycloalkyl, optionally substituted C6-20 aryl, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted 5- to 20-membered heteroaryl, wherein the C3-20 cycloalkyl, the C6-20 aryl, the 4- to 20-membered heterocyclyl, and the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof, and wherein the C3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof.

6. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in any one of claims 1-3, wherein Ra represents the following formula:         Ra1-X2-L1-X1-, wherein X1 represents a bond, or X1 represents N(R1), O, S, C2-6 alkynylene or C2-6 alkenylene, wherein R1 represents H or C1-3 alkyl; L1 represents linear or branched C1-60 alkylene optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, C1-6 alkoxy, or any combination thereof; X2 represents a bond, or X2 represents N(R2), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, OS(O)2, optionally substituted 4- to 8-membered heterocyclylene containing 1 to 2 nitrogen atoms, triazolylene, triazolylene-NH-, -NH-triazolylene, or optionally substituted phenylene, wherein R2 represents H or C1-3 alkyl, and the 4- to 8-membered heterocyclylene containing 1 to 2 nitrogen atoms is optionally substituted with 1 to 8 substituents selected from the group consisting of D, halogen, optionally deuterated C1-4 alkyl, oxo, hydroxy, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, cyano, or any combination thereof, and the phenylene is optionally substituted with 1 to 4 substituents selected from the group consisting of D, halogen, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, cyano, or any combination thereof; and Ra1 represents hydroxy, optionally substituted adamantanyl, optionally substituted noradamantanyl, optionally substituted cubanyl, optionally substituted spirocycloalkyl, optionally substituted bicyclo[2.2.2]octan-1-yl, optionally substituted bicyclo[2.2.2]octan-2-yl, optionally substituted bornyl, optionally substituted bicyclo[2.2.1]heptanyl, optionally substituted bicyclo[2.2.1]heptenyl, optionally substituted p-menthanyl or optionally substituted m-menthanyl, wherein when Ra1 represents hydroxy, X2 represents a bond, and the adamantanyl, noradamantanyl, cubanyl, spirocycloalkyl, bicyclo[2.2.2]octan-1-yl, bicyclo[2.2.2]octan-2-yl, bornyl, bicyclo[2.2.1]heptanyl, bicyclo[2.2.1]heptenyl, p-menthanyl and m-menthanyl are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; and Rb represents C1-60 alkyl optionally substituted with D or halogen, or Rb represents the following formula:         Rb1-X4-L2-, wherein L2 represents linear or branched C2-60 alkylene optionally substituted with one or more substituents selected from the group consisting of D, C1-4 alkyl, halogen, C3-6 cycloalkyl or any combination thereof, or optionally substituted linear or branched C2-60 alkylene with one or more groups R12 and / or one or more groups R13 and / or any combination of one or more groups R12 and R13 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R12, R13, or a combination of R12 and R13; wherein each R12 is independently selected from the group consisting of O, S, N(R14), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, wherein R14 independently represents H or C1-3 alkyl, and in case that two or more groups R12 are inserted into the backbone carbon chain of the linear or branched C2-60 alkylene group, the two or more groups R12 are not directly connected to each other; and wherein each R13 is independently selected from the group consisting of C3-15 cycloalkylene, 4- to 15-membered heterocyclylene, C6-10 arylene, 5- to 15-membered heteroarylene or any combination thereof, wherein the C3-15 cycloalkylene, the 4- to 15-membered heterocyclylene, C6-10 arylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, cyano or any combination thereof, and the linear or branched C2-60 alkylene is optionally substituted with one or more substituents selected from the group consisting of D, C1-4 alkyl, halogen, C3-6 cycloalkyl or any combination thereof; X4 represents a bond, or X4 represents N(R15), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, OS(O)2, optionally substituted C3-20 cycloalkylene, optionally substituted C6-20 arylene, optionally substituted 4- to 20-membered heterocyclylene, optionally substituted 5- to 20-membered heteroarylene, triazolylene-NH-, or -NH-triazolylene, wherein R15 represents H or C1-3 alkyl, and the C3-20 cycloalkylene, the C6-20 arylene, the 4- to 20-membered heterocyclylene, and the 5- to 20-membered heteroarylene are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; and Rb1 represents optionally substituted C3-20 cycloalkyl, optionally substituted C6-20 aryl, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted 5- to 20-membered heteroaryl, wherein the C3-20 cycloalkyl, the C6-20 aryl, the 4- to 20-membered heterocyclyl, and the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15 cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof, and the C3-15 cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof.

7. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in any one of claims 1-3, wherein Ra represents the following formula:         Ra1-X2-L1-X1-, wherein X1 represents N(R3), O or S, wherein R3 represents H or C1-3 alkyl; L1 represents linear or branched C4-60 alkylene optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, C1-6 alkoxy, or any combination thereof; X2 represents a bond, or X2 represents N(R4), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, or OS(O)2, wherein R4 represents H or C1-3 alkyl; and Ra1 represents optionally substituted 4- to 20-membered heterocyclyl, and the 4- to 20-membered heterocyclyl is optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15 cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof, and the C3-15 cycloalkyl, the 4-to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; and Rb represents C1-60 alkyl optionally substituted with D or halogen, or Rb represents the following formula:         Rb1-X4-L2- , wherein L2 represents linear or branched C2-60 alkylene optionally substituted with one or more substituents selected from the group consisting of D, C1-4 alkyl, halogen, C3-6 cycloalkyl or any combination thereof, or optionally substituted linear or branched C2-60 alkylene with one or more groups R12 and / or one or more groups R13 and / or any combination of one or more groups R12 and R13 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R12, R13, or a combination of R12 and R13; wherein each R12 is independently selected from the group consisting of O, S, N(R14), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, wherein R14 independently represents H or C1-3 alkyl, and in case that two or more groups R12 are inserted into the backbone carbon chain of the linear or branched C2-60 alkylene group, the two or more groups R12 are not directly connected to each other; and wherein each R13 is independently selected from the group consisting of C3-15 cycloalkylene, 4- to 15-membered heterocyclylene, C6-10 arylene, 5- to 15-membered heteroarylene, C2-6 alkenylene, C2-6 alkynylene or any combination thereof, wherein the C3-15 cycloalkylene, the 4- to 15-membered heterocyclylene, C6-10 arylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH- or any combination thereof, and the linear or branched C2-60 alkylene is optionally substituted with one or more substituents selected from the group consisting of D, C1-4 alkyl, halogen, C3-6 cycloalkyl or any combination thereof; X4 represents a bond, or X4 represents N(R15), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, OS(O)2, optionally substituted C3-20 cycloalkylene, optionally substituted C6-20 arylene, optionally substituted 4- to 20-membered heterocyclylene, optionally substituted 5- to 20-membered heteroarylene, triazolylene-NH-, or -NH-triazolylene, wherein R15 represents H or C1-3 alkyl, and the C3-20 cycloalkylene, the C6-20 arylene, the 4- to 20-membered heterocyclylene, and the 5- to 20-membered heteroarylene are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; and Rb1 represents optionally substituted C3-20 cycloalkyl, optionally substituted C6-20 aryl, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted 5- to 20-membered heteroaryl, wherein the C3-20 cycloalkyl, the C6-20 aryl, the 4- to 20-membered heterocyclyl, and the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15 cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof, and the C3-15 cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof.

8. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in any one of claims 1-3, wherein Ra represents the following formula:         Ra1-X2-L1-X1- , wherein X1 represents a bond, or X1 represents C2-6 alkynylene or C2-6 alkenylene; L1 represents linear or branched C1-60 alkylene optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, C1-6 alkoxy, or any combination thereof; and X2 represents a bond, or X2 represents N(Rs), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, or OS(O)2, wherein R5 represents H or C1-3 alkyl; and Ra1 represents optionally substituted 4- to 20-membered heterocyclyl, wherein the 4- to 20-membered heterocyclyl is optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15 cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof, and the C3-15 cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; and Rb represents C1-60 alkyl optionally substituted with D or halogen, or Rb represents the following formula:         Rb1-X4-L2-, wherein L2 represents linear or branched C2-60 alkylene optionally substituted with one or more substituents selected from the group consisting of D, C1-4 alkyl, halogen, C3-6 cycloalkyl or any combination thereof, or optionally substituted linear or branched C2-60 alkylene with one or more groups R12 and / or one or more groups R13 and / or any combination of one or more groups R12 and R13 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R12, R13, or a combination of R12 and R13; wherein each R12 is independently selected from the group consisting of O, S, N(R14), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, wherein R14 independently represents H or C1-3 alkyl, and in case that two or more groups R12 are inserted into the backbone carbon chain of the linear or branched C2-60 alkylene group, the two or more groups R12 are not directly connected to each other; and wherein each R13 is independently selected from the group consisting of C3-15 cycloalkylene, 4- to 15-membered heterocyclylene, C6-10 arylene, 5- to 15-membered heteroarylene, C2-6 alkenylene, C2-6 alkynylene or any combination thereof, wherein the C3-15 cycloalkylene, the 4- to 15-membered heterocyclylene, C6-10 arylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH- or any combination thereof, and the linear or branched C2-60 alkylene is optionally substituted with one or more substituents selected from the group consisting of D, C1-4 alkyl, halogen, C3-6 cycloalkyl or any combination thereof; X4 represents a bond, or X4 represents N(R15), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, OS(O)2, optionally substituted C3-20 cycloalkylene, optionally substituted C6-20 arylene, optionally substituted 4- to 20-membered heterocyclylene, optionally substituted 5- to 20-membered heteroarylene, triazolylene-NH-, or -NH-triazolylene, wherein R15 represents H or C1-3 alkyl, and the C3-20 cycloalkylene, the C6-20 arylene, the 4- to 20-membered heterocyclylene, and the 5- to 20-membered heteroarylene are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; and Rb1 represents optionally substituted C3-20 cycloalkyl, optionally substituted C6-20 aryl, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted 5- to 20-membered heteroaryl, wherein the C3-20 cycloalkyl, the C6-20 aryl, the 4- to 20-membered heterocyclyl, and the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15 cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof, and wherein the C3-15 cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof.

9. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in any one of claims 1-3, wherein Ra represents the following formula:         Ra1-X2-L1-X1- , wherein X1 represents a bond, or X1 represents N(R6), O, S, C2-6 alkynylene, or C2-6 alkenylene, wherein R6 represents H or C1-3 alkyl; L1 represents optionally substituted linear or branched C2-60 alkylene with one or more groups R7 and / or one or more groups Rs and / or any combination of one or more groups R7 and R8 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R7, R8, or a combination of R7 and Rs; wherein each R7 is independently selected from the group consisting of O, S, N(R9), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, wherein R9 represents H or C1-3 alkyl, and in case that two or more groups R7 are inserted into the backbone carbon chain of the linear or branched C2-60 alkylene group, the two or more groups R7 are not directly connected to each other; and wherein each Rs is independently selected from the group consisting of C3-15 cycloalkylene, 4- to 15-membered heterocyclylene, triazolylene or any combination thereof, wherein the C3-15 cycloalkylene, the 4- to 15-membered heterocyclylene and the triazolylene are each independently optionally substituted with a substituent selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof, and the linear or branched C2-60 alkylene is optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, C1-6 alkoxy, or any combination thereof; X2 represents a bond, or X2 represents N(R10), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, OS(O)2, optionally substituted 4- to 8-membered heterocyclylene containing 1 to 2 nitrogen atoms, triazolylene, triazolylene-NH-, -NH-triazolylene, or optionally substituted phenylene, wherein R10 represents H or C1-3 alkyl, and the 4- to 8-membered heterocyclylene containing 1 to 2 nitrogen atoms is optionally substituted with 1 to 8 substituents selected from the group consisting of D, halogen, optionally deuterated C1-4 alkyl, oxo, hydroxy, amino, mercapto, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof, and the phenylene is optionally substituted with 1 to 4 substituents selected from the group consisting of D, halogen, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; and Ra1 represents hydroxy, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted C3-20 cycloalkyl, wherein when Ra1 represents hydroxy, X2 represents a bond, and the 4- to 20-membered heterocyclyl and the C3-20 cycloalkyl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15 cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof, and wherein the C3-15 cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; and Rb represents C1-60 alkyl optionally substituted with D or halogen, or Rb represents the following formula:         Rb1-X4-L2-, wherein L2 represents linear or branched C2-60 alkylene optionally substituted with one or more substituents selected from the group consisting of D, C1-4 alkyl, halogen, C3-6 cycloalkyl or any combination thereof, or optionally substituted linear or branched C2-60 alkylene with one or more groups R12 and / or one or more groups R13 and / or any combination of one or more groups R12 and R13 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R12, R13, or a combination of R12 and R13; wherein each R12 is independently selected from the group consisting of O, S, N(R14), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, wherein R14 independently represents H or C1-3 alkyl, and in case that two or more groups R12 are inserted into the backbone carbon chain of the linear or branched C2-60 alkylene group, the two or more groups R12 are not directly connected to each other; and wherein each R13 is independently selected from the group consisting of C3-15 cycloalkylene, 4- to 15-membered heterocyclylene, C6-10 arylene, 5- to 15-membered heteroarylene, C2-6 alkenylene, C2-6 alkynylene or any combination thereof, wherein the C3-15 cycloalkylene, the 4- to 15-membered heterocyclylene, C6-10 arylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof, and the linear or branched C2-60 alkylene is optionally substituted with one or more substituents selected from the group consisting of D, C1-4 alkyl, halogen, C3-6 cycloalkyl or any combination thereof; X4 represents a bond, or X4 represents N(R15), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, OS(O)2, optionally substituted C3-20 cycloalkylene, optionally substituted C6-20 arylene, optionally substituted 4- to 20-membered heterocyclylene, optionally substituted 5- to 20-membered heteroarylene, triazolylene-NH-, or -NH-triazolylene, wherein R15 represents H or C1-3 alkyl, and the C3-20 cycloalkylene, the C6-20 arylene, the 4- to 20-membered heterocyclylene, and the 5- to 20-membered heteroarylene are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; and Rb1 represents optionally substituted C3-20 cycloalkyl, optionally substituted C6-20 aryl, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted 5- to 20-membered heteroaryl, wherein the C3-20 cycloalkyl, the C6-20 aryl, the 4- to 20-membered heterocyclyl, and the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15 cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, C1-3 alkoxy, C1-3 alkyl-NH-, halogenated C1-3 alkyl, NH2-C1-3 alkylene, C1-3 alkyl-NHC(O)-, C1-3 alkyl-C(O)NH-, cyano or any combination thereof, and wherein the C3-15 cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof.

10. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in any one of claims 1-3, wherein Ra represents the following formula:         Ra2-X3- , wherein X3 represents N(R11), C(O)O, OC(O), C(O)NH, NHC(O), O, S, optionally substituted C3-20 cycloalkylene, optionally substituted C6-20 arylene, optionally substituted 5- to 20-membered heteroarylene or optionally substituted 4- to 20-membered heterocyclylene, wherein R11 represents H or C1-3 alkyl, wherein the C3-20 cycloalkylene and the 4- to 20-membered heterocyclylene are each independently optionally substituted with 1 to 8 substituents selected from the group consisting of D, halogen, optionally deuterated C1-4 alkyl, oxo, or any combination thereof, and the C6-20 arylene and the 5- to 20-membered heteroarylene are each independently optionally substituted with 1 to 8 substituents selected from the group consisting of D, halogen, optionally deuterated C1-4 alkyl, or any combination thereof, and Ra2 represents optionally substituted C3-20 cycloalkyl, optionally substituted 4- to 20-membered heterocyclyl, optionally substituted 5- to 20-membered heteroaryl or optionally substituted C6-20 aryl, wherein the C3-20 cycloalkyl, the C6-20 aryl, the 4- to 20-membered heterocyclyl, and the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15 cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof, and the C3-15 cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; and Rb represents C1-60 alkyl optionally substituted with D or halogen, or Rb represents the following formula:         Rb1-X4-L2- , wherein L2 represents linear or branched C2-60 alkylene optionally substituted with one or more substituents selected from the group consisting of D, C1-4 alkyl, halogen, C3-6 cycloalkyl or any combination thereof, or optionally substituted linear or branched C2-60 alkylene with one or more groups R12 and / or one or more groups R13 and / or any combination of one or more groups R12 and R13 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R12, R13, or a combination of R12 and R13; wherein each R12 is independently selected from the group consisting of O, S, N(R14), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, wherein R14 independently represents H or C1-3 alkyl, and in case that two or more groups R12 are inserted into the backbone carbon chain of the linear or branched C2-60 alkylene group, the two or more groups R12 are not directly connected to each other; and wherein each R13 is independently selected from the group consisting of C3-15 cycloalkylene, 4- to 15-membered heterocyclylene, C6-10 arylene, 5- to 15-membered heteroarylene, C2-6 alkenylene, C2-6 alkynylene or any combination thereof, wherein the C3-15 cycloalkylene, the 4- to 15-membered heterocyclylene, C6-10 arylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof, and the linear or branched C2-60 alkylene is optionally substituted with one or more substituents selected from the group consisting of D, C1-4 alkyl, halogen, C3-6 cycloalkyl or any combination thereof; X4 represents a bond, or X4 represents N(R15), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, OS(O)2, optionally substituted C3-20 cycloalkylene, optionally substituted C6-20 arylene, optionally substituted 4- to 20-membered heterocyclylene, optionally substituted 5- to 20-membered heteroarylene, triazolylene-NH-, or -NH-triazolylene, wherein R15 represents H or C1-3 alkyl, and the C3-20 cycloalkylene, the C6-20 arylene, the 4- to 20-membered heterocyclylene, and the 5- to 20-membered heteroarylene are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; and Rb1 represents optionally substituted C3-20 cycloalkyl, optionally substituted C6-20 aryl, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted 5- to 20-membered heteroaryl, wherein the C3-20 cycloalkyl, the C6-20 aryl, the 4- to 20-membered heterocyclyl, and the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15 cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof, and wherein the C3-15 cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof.

11. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in any one of claims 1-3, wherein Ra represents halogen or cyano, and Rb represents the following formula:         Rb2-X5-L3-, wherein L3 represents linear or branched C2-60 alkylene optionally substituted with one or more substituents selected from the group consisting of D, C1-4 alkyl, halogen, C3-6 cycloalkyl or any combination thereof, or optionally substituted linear or branched C2-60 alkylene with one or more groups R16 and / or one or more groups R17 and / or any combination of one or more groups R16 and R17 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R16, R17, or a combination of R16 and R17; wherein each R16 is independently selected from the group consisting of O, S, N(R18), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, wherein R18 represents H or C1-3 alkyl, and in case that two or more groups R16 are inserted into the backbone carbon chain of the linear or branched C2-60 alkylene group, the two or more groups R16 are not directly connected to each other; and wherein each R17 is independently selected from the group consisting of C3-15 cycloalkylene, 4- to 15-membered heterocyclylene, C6-10 arylene, 5- to 15-membered heteroarylene, C2-6 alkenylene, C2-6 alkynylene or any combination thereof, wherein the C3-15 cycloalkylene, the 4- to 15-membered heterocyclylene, C6-10 arylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof, and the linear or branched C2-60 alkylene is optionally substituted with one or more substituents selected from the group consisting of D, C1-4 alkyl, halogen, C3-6 cycloalkyl or any combination thereof; X5 represents N(R19), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, or OS(O)2, wherein R19 represents H or C1-3 alkyl, or X5 represents a bond; and Rb2 represents optionally substituted C3-20 cycloalkyl, optionally substituted C6-20 aryl, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted 5- to 20-membered heteroaryl, wherein the C3-20 cycloalkyl, the C6-20 aryl, the 4- to 20-membered heterocyclyl, and the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15 cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof, and wherein the C3-15 cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; or Rb2 represents the following formula: wherein Rf1, Rf2, Rf3, Rf4 and Rf5 are as defined in claim 1.

12. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 4, wherein X1 represents optionally substituted C3-20 cycloalkylene, optionally substituted 4- to 20-membered nitrogen-containing monocyclic heterocyclylene, optionally substituted 5- to 20-membered nitrogen-containing bridged heterocyclylene, optionally substituted 5- to 20-membered nitrogen-containing spiro-heterocyclylene, optionally substituted 5- to 20-membered nitrogen-containing fused heterocyclylene, optionally substituted C6-10 arylene, or optionally substituted 5- to 20-membered heteroarylene, wherein the C3-20 cycloalkylene, the 4- to 20-membered nitrogen-containing monocyclic heterocyclylene, the 5- to 20-membered nitrogen-containing bridged heterocyclylene, the 5- to 20-membered nitrogen-containing spiro-heterocyclylene, the 5- to 20-membered nitrogen-containing fused heterocyclylene, the C6-10 arylene, and the 5- to 20-membered heteroarylene are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; or Ra1 represents NRd4Rd5, C(O)NRd6Rd7, NHC(O)Ras, NHC(O)NRd9Ra10, C(O)ORd11, OC(O)Rd12, ORd13, SRd14, C(O)Rd15, C(S)Rd16, S(O)Rd17, S(O)2Rd18, S(O)2NHRd19, NHS(O)2Rd20, S(O)2ORd21, OS(O)2Rd22, optionally substituted linear or branched C1-10 alkyl, optionally substituted C3-20 cycloalkyl, optionally substituted 4- to 20-membered heterocyclyl, optionally substituted C6-20 aryl or optionally substituted 5- to 20-membered heteroaryl, wherein the linear or branched C1-10 alkyl, the C3-20 cycloalkyl, the 4- to 20-membered heterocyclyl, the C6-20 aryl or the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof; wherein Rd4, Rd5, Rd6, Rd7, Rd9, Rd10, Rd11, Rd13, Rd14, Rd19 and Kd21 each independently represent H, optionally substituted linear or branched C1-10 alkyl, optionally substituted C3-20 cycloalkyl, optionally substituted C6-20 aryl, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted 5- to 20-membered heteroaryl, wherein the linear or branched C1-10 alkyl, the C3-20 cycloalkyl, the 4- to 20-membered heterocyclyl, the C6-20 aryl or the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof; and Rd8, Rd12, Rd15, Rd16, Rd17, Rd18, Rd20 and Rd22 each independently represent optionally substituted linear or branched C1-10 alkyl, optionally substituted C3-20 cycloalkyl, optionally substituted 4- to 20-membered heterocyclyl, optionally substituted C6-20 aryl or optionally substituted 5- to 20-membered heteroaryl, wherein the linear or branched C1-10 alkyl, the C3-20 cycloalkyl, the 4- to 20-membered heterocyclyl, the C6-20 aryl or the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, halogenated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof; preferably, wherein X1 represents: cyclopropylene, cyclobutylene, cyclopentylene, cyclopentenylene, cyclohexylene, cyclohexenylene, cycloheptylene, cyclooctylene, decalinylene, octahydropentalenylene, octahydro-1H-indenylene, spiro[3.3]heptylene, spiro[2.5]octylene, spiro[3.5]nonylene, spiro[4.4]nonylene, spiro[4.5]decylene, spiro[5.5]undecylene, p-menthanylene, m-menthanylene, quinuclidinylene, adamantanylene, noradamantanylene, bornylene, bicyclo[2.2.1]heptanylene, 2-oxobicyclo[2.2.1]heptanylene or bicyclo[2.2.1]heptenylene, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, halogenated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; phenylene or naphthylene, wherein the phenylene or naphthylene is optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, halogenated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; azetidinylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, oxazolidinylene, thiazolidinylene, piperidinylene, piperazinylene, morpholinylene, thiomorpholinylene, azepanylene, azacyclooctylene, diazacycloheptanylene, diazacyclooctylene, 3-azabicyclo[3.1.0]hexylene, 6-azabicyclo[3.1.1]heptanylene, 2,5-diazabicyclo[2.2.1]heptanylene, 3,6-diazabicyclo[3.1.1]heptanylene, 3-azabicyclo[3.2.1]octylene, 3,8-diazabicyclo[3.2.1]octylene, 2,5-diazabicyclo[2.2.2]octylene, 3-azaspiro[5.5]undecylene or 7-azaspiro[3.5]nonylene, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, halogenated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; or furanylene, oxazolylene, isoxazolylene, oxadiazolylene, thienylene, thiazolylene, isothiazolylene, thiadiazolylene, pyrrolylene, imidazolylene, pyrazolylene, triazolylene, pyridylene, pyrimidinylene, pyridazinylene, pyrazinylene, indolylene, isoindolylene, benzofuranylene, isobenzofuranylene, benzothienylene, indazolylene, benzimidazolylene, benzoxazolylene, benzisoxazolylene, benzothiazolylene, benzisothiazolylene, benzotriazolylene, benzo[2,1,3]oxadiazolylene, benzo[2,1,3]thiadiazolylene, benzo[1,2,3]thiadiazolylene, quinolinylene, isoquinolinylene, naphthyridinylene, cinnolinylene, quinazolinylene, quinoxalinylene, phthalazinylene, pyrazolo[1,5-a]pyridylene, pyrazolo[1,5-a]pynmidinylene, imidazo[1,2-a]pyridylene, 1H-pyrrolo[3,2-b]pyridylene, 1H-pyrrolo[2,3-b]pyridylene, 4H-fluoro[3,2-b]pyrrolylene, pyrrolo[2,1-b]thiazolylene, and imidazo[2,1-b]thiazolylene, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, halogenated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; or Ra1 represents NRd4Rd5, C(O)NRd6Rd7, NHC(O)Rd8, NHC(O)NRd9Rd10, C(O)ORd11, OC(O)Rd12, ORd13, SRd14, C(O)Rd15, C(S)Rd16, S(O)Rd17, S(O)2Rd18, S(O)2NHRd19, NHS(O)2Rd20, S(O)2ORd21, or OS(O)2Rd22, wherein Rd4, Rd5, Rd6, Rd7, Rd9, Rd10, Rd11, Rd13, Rd14, Rd19 and Rd21 are the same or different and each independently represent: H, or methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, pentyl, isopentyl, neopentyl, tert-pentyl, hexyl, heptyl, octyl, nonyl or decyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene or any combination thereof; or cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bomyl, bicyclo[2.2.1]heptanyl, or bicyclo[2.2.1]heptenyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene or any combination thereof; or phenyl or naphthyl, wherein the phenyl or naphthyl is optionally substituted with one or more substituents selected from the group consisting of optionally deuterated C1-4 alkyl, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene or any combination thereof; or azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 3-azabicyclo[3. 1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octyl, 2,5-diazabicyclo[2.2.2]octyl, or azaspirocycloalkyl (e.g., 3-azaspiro[5.5]undecyl or 7-azaspiro[3.5]nonyl), with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene or any combination thereof; furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl or imidazo[2,1-b]thiazolyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene or any combination thereof; and Rd8, Rd12, Rd15, Rd16, Rd17, Rd18, Rd20 and Rd22 each independently represent: methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, pentyl, isopentyl, neopentyl, tert-pentyl, hexyl, heptyl, octyl, nonyl or decyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, optionally substituted C3-15cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene or any combination thereof; or cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptanyl, or bicyclo[2.2.1]heptenyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, optionally substituted C3-15cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4-to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene or any combination thereof; or phenyl or naphthyl, wherein the phenyl or naphthyl is optionally substituted with one or more substituents selected from the group consisting of halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene or any combination thereof; or azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 3-azabicyclo[3. 1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octyl, 2,5-diazabicyclo[2.2.2]octyl, or azaspirocycloalkyl (e.g., 3-azaspiro[5.5]undecyl or 7-azaspiro[3.5]nonyl), with each group being optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C3-15cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene or any combination thereof; furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl or imidazo[2,1-b]thiazolyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene or any combination thereof; or Ra1 represents: methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, pentyl, isopentyl, neopentyl, tert-pentyl, hexyl, heptyl, octyl, nonyl or decyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene or any combination thereof; or cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptanyl, or bicyclo[2.2.1]heptenyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene or any combination thereof; or phenyl or naphthyl, wherein the phenyl or naphthyl is optionally substituted with one or more substituents selected from the group consisting of halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene or any combination thereof; or azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octyl, 2,5-diazabicyclo[2.2.2]octyl, or azaspirocycloalkyl (e.g., 3-azaspiro[5.5]undecyl or 7-azaspiro[3.5]nonyl), with each group being optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, optionally substituted C3-15cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5-to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C3-15cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene or any combination thereof; or furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl or imidazo[2,1-b]thiazolyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, optionally substituted C3-15cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5-to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C3-15cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene or any combination thereof.

13. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 5, wherein (i) X1 represents a bond, or X1 represents N(Re1), O, S, C2-6 alkynylene, C2-6 alkenylene, optionally substituted C3-20cycloalkylene, optionally substituted 4- to 20-membered heterocyclylene, optionally substituted C6-15 arylene, or optionally substituted 5- to 20-membered heteroarylene, wherein Re1 represents H or C1-3 alkyl, wherein the C3-20 cycloalkylene, the 4- to 20-membered heterocyclylene, the C6-15 arylene, and the 5- to 20-membered heteroarylene are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; preferably, wherein X1 represents a bond, or X1 represents N(Re1), O, S, C2-6 alkynylene or C2-6 alkenylene, wherein Re1 represents H or C1-3 alkyl; or X1 represents: cyclopropylene, cyclobutylene, cyclopentylene, cyclopentenylene, cyclohexylene, cyclohexenylene, cycloheptylene, cyclooctylene, decalinylene, octahydropentalenylene, octahydro-1H-indenylene, spiro[3.3]heptylene, spiro[2.5]octylene, spiro[3.5]nonylene, spiro[4.4]nonylene, spiro[4.5]decylene, spiro[5.5]undecylene, p-menthanylene, m-menthanylene, quinuclidinylene, adamantanylene, noradamantanylene, bornylene, bicyclo[2.2.1]heptanylene, 2-oxobicyclo[2.2.1]heptanylene or bicyclo[2.2.1]heptenylene, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, halogenated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; phenylene or naphthylene, wherein the phenylene or naphthylene is optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, halogenated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; azetidinylene, oxetanylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, tetrahydrofuranylene, tetrahydropyranylene, tetrahydrothienylene, tetrahydrothiopyranylene, oxazolidinylene, thiazolidinylene, piperidinylene, piperazinylene, morpholinylene, thiomorpholinylene, dioxacyclohexylene, azacycloheptanylene, azacyclooctylene, diazacycloheptanylene, diazacyclooctylene, 3-azabicyclo[3.1.0]hexylene, 6-azabicyclo[3.1.1]heptanylene, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octylene, 3,8-diazabicyclo[3.2.1]octylene, 2,5-diazabicyclo[2.2.2]octylene, 3-azaspiro[5.5]undecylene or 7-azaspiro[3.5]nonylene, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, halogenated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; or furanylene, oxazolylene, isoxazolylene, oxadiazolylene, thienylene, thiazolylene, isothiazolylene, thiadiazolylene, pyrrolylene, imidazolylene, pyrazolylene, triazolylene, pyridylene, pyrimidinylene, pyridazinylene, pyrazinylene, indolylene, isoindolylene, benzofuranylene, isobenzofuranylene, benzothienylene, indazolylene, benzimidazolylene, benzoxazolylene, benzisoxazolylene, benzothiazolylene, benzisothiazolylene, benzotriazolylene, benzo[2,1,3]oxadiazolylene, benzo[2,1,3]thiadiazolylene, benzo[1,2,3]thiadiazolylene, quinolinylene, isoquinolinylene, naphthyridinylene, cinnolinylene, quinazolinylene, quinoxalinylene, phthalazinylene, pyrazolo[1,5-a]pyridylene, pyrazolo[1,5-a]pyrimidinylene, imidazo[1,2-a]pyridylene, 1H-pyrrolo[3,2-b]pyridylene, 1H-pyrrolo[2,3-b]pyridylene, 4H-fluoro[3,2-b]pyrrolylene, pyrrolo[2,1-b]thiazolylene or imidazo[2,1-b]thiazolylene, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, halogenated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; or (ii) Ra1 represents the following formula: wherein Rf1 represents:         -NCH2CH2N-; wherein symbol * indicates the point of attachment to X2, Rg1 represents H or C1-3 alkyl, ring A represents: cyclopropylene, cyclobutylene, cyclopentylene, cyclopentenylene, cyclohexylene, cyclohexenylene, cycloheptylene, cyclooctylene, decalinylene, octahydropentalenylene, octahydro-1H-indenylene, spiro[3.3]heptylene, spiro[2.5]octylene, spiro[3.5]nonylene, spiro[4.4]nonylene, spiro[4.5]decylene, spiro[5.5]undecylene, p-menthanylene, m-menthanylene, quinuclidinylene, adamantanylene, noradamantanylene, bornylene, bicyclo[2.2.1]heptanylene, 2-oxobicyclo[2.2.1]heptanylene, bicyclo[2.2.1]heptenylene, azetidinylene, oxetanylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, tetrahydrofuranylene, tetrahydropyranylene, tetrahydrothienylene, tetrahydrothiopyranylene, oxazolidinylene, thiazolidinylene, piperidinylene, piperazinylene, morpholinylene, thiomorpholinylene, dioxacyclohexylene, azacycloheptanylene, azacyclooctylene, diazacycloheptanylene, diazacyclooctylene, 3-azabicyclo[3.1.0]hexylene, 6-azabicyclo[3.1.1]heptanylene, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octylene, 3,8-diazabicyclo[3.2.1]octylene, 2,5-diazabicyclo[2.2.2]octylene, 3-azaspiro[5.5]undecylene or 7-azaspiro[3.5]nonylene, and (Rg2)n1 indicates that ring A is optionally substituted with n1 Rg2, n1 represents an integer of 0 to 8, and each Rg2, the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, NH2-C1-6 alkylene or any combination thereof; wherein symbol ** indicates the point of attachment to X2, Rg3 represents H or C1-3 alkyl, ring B represents: cyclopropylene, cyclobutylene, cyclopentylene, cyclopentenylene, cyclohexylene, cyclohexenylene, cycloheptylene, cyclooctylene, decalinylene, octahydropentalenylene, octahydro-1H-indenylene, spiro[3.3]heptylene, spiro[2.5]octylene, spiro[3.5]nonylene, spiro[4.4]nonylene, spiro[4.5]decylene, spiro[5.5]undecylene, p-menthanylene, m-menthanylene, quinuclidinylene, adamantanylene, noradamantanylene, bornylene, bicyclo[2.2.1]heptanylene, 2-oxobicyclo[2.2.1]heptanylene, bicyclo[2.2.1]heptenylene, azetidinylene, oxetanylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, tetrahydrofuranylene, tetrahydropyranylene, tetrahydrothienylene, tetrahydrothiopyranylene, oxazolidinylene, thiazolidinylene, piperidinylene, piperazinylene, morpholinylene, thiomorpholinylene, dioxacyclohexylene, azacycloheptanylene, azacyclooctylene, diazacycloheptanylene, diazacyclooctylene, 3-azabicyclo[3.1.0]hexylene, 6-azabicyclo[3.1.1]heptanylene, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octylene, 3,8-diazabicyclo[3.2.1]octylene, 2,5-diazabicyclo[2.2.2]octylene, 3-azaspiro[5.5]undecylene or 7-azaspiro[3.5]nonylene, and (Rg4)n2 indicates that ring B is optionally substituted with n2 Rg4, n2 represents an integer of 0 to 8, and each Rg4, the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, NH2-C1-6 alkylene or any combination thereof; or wherein ring C represents: cyclopropylene, cyclobutylene, cyclopentylene, cyclopentenylene, cyclohexylene, cyclohexenylene, cycloheptylene, cyclooctylene, decalinylene, octahydropentalenylene, octahydro-1H-indenylene, spiro[3.3]heptylene, spiro[2.5]octylene, spiro[3.5]nonylene, spiro[4.4]nonylene, spiro[4.5]decylene, spiro[5.5]undecylene, p-menthanylene, m-menthanylene, quinuclidinylene, adamantanylene, noradamantanylene, bornylene, bicyclo[2.2.1]heptanylene, 2-oxobicyclo[2.2.1]heptanylene, bicyclo[2.2.1]heptenylene, azetidinylene, oxetanylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, tetrahydrofuranylene, tetrahydropyranylene, tetrahydrothienylene, tetrahydrothiopyranylene, oxazolidinylene, thiazolidinylene, piperidinylene, piperazinylene, morpholinylene, thiomorpholinylene, dioxacyclohexylene, azacycloheptanylene, azacyclooctylene, diazacycloheptanylene, diazacyclooctylene, 3-azabicyclo[3.1.0]hexylene, 6-azabicyclo[3.1.1]heptanylene, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octylene, 3,8-diazabicyclo[3.2.1]octylene, 2,5-diazabicyclo[2.2.2]octylene, 3-azaspiro[5.5]undecylene or 7-azaspiro[3.5]nonylene, and (Rg5)n3 indicates that ring C is optionally substituted with n3 Rg5, n3 represents an integer of 0 to 8, and each Rg5, the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, NH2-C1-6 alkylene or any combination thereof; Rf2 represents H, halogen, C1-3 alkyl or halogenated C1-3 alkyl; Rf3 represents H, halogen, C1-3 alkyl, halogenated C1-3 alkyl, or wherein ring D represents: cyclopropylene, cyclobutylene, cyclopentylene, cyclopentenylene, cyclohexylene, cyclohexenylene, cycloheptylene, cyclooctylene, decalinylene, octahydropentalenylene, octahydro-1H-indenylene, spiro[3.3]heptylene, spiro[2.5]octylene, spiro[3.5]nonylene, spiro[4.4]nonylene, spiro[4.5]decylene, spiro[5.5]undecylene, p-menthanylene, m-menthanylene, quinuclidinylene, adamantanylene, noradamantanylene, bornylene, bicyclo[2.2.1]heptanylene, 2-oxobicyclo[2.2.1]heptanylene, bicyclo[2.2.1]heptenylene, azetidinylene, oxetanylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, tetrahydrofuranylene, tetrahydropyranylene, tetrahydrothienylene, tetrahydrothiopyranylene, oxazolidinylene, thiazolidinylene, piperidinylene, piperazinylene, morpholinylene, thiomorpholinylene, dioxacyclohexylene, azacycloheptanylene, azacyclooctylene, diazacycloheptanylene, diazacyclooctylene, 3-azabicyclo[3.1.0]hexylene, 6-azabicyclo[3.1.1]heptanylene, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octylene, 3,8-diazabicyclo[3.2.1]octylene, 2,5-diazabicyclo[2.2.2]octylene, 3-azaspiro[5.5]undecylene, 7-azaspiro[3.5]nonylene, phenylene, naphthylene, furanylene, oxazolylene, isoxazolylene, oxadiazolylene, thienylene, thiazolylene, isothiazolylene, thiadiazolylene, pyrrolylene, imidazolylene, pyrazolylene, triazolylene, pyridylene, pyrimidinylene, pyridazinylene, pyrazinylene, indolylene, isoindolylene, benzofuranylene, isobenzofuranylene, benzothienylene, indazolylene, benzimidazolylene, benzoxazolylene, benzisoxazolylene, benzothiazolylene, benzisothiazolylene, benzotriazolylene, benzo[2,1,3]oxadiazolylene, benzo[2,1,3]thiadiazolylene, benzo[1,2,3]thiadiazolylene, quinolinylene, isoquinolinylene, naphthyridinylene, cinnolinylene, quinazolinylene, quinoxalinylene, phthalazinylene, pyrazolo[1,5-a]pyridylene, pyrazolo[1,5-a]pyrimidinylene, imidazo[1,2-a]pyridylene, 1H-pyrrolo[3,2-b]pyridylene, 1H-pyrrolo[2,3-b]pyridylene, 4H-fluoro[3,2-b]pyrrolylene, pyrrolo[2,1-b]thiazolylene or imidazo[2,1-b]thiazolylene, and (Rg6)n4 indicates that ring D is optionally substituted with n4 Rg6, n4 represents an integer of 0 to 8, and each Rg6, the same or different from each other, is independently selected from the group consisting of optionally deuterated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, NH2-C1-6 alkylene or any combination thereof; Rf4 represents wherein symbol *** indicates the point of attachment to Rf5, ring E represents: cyclopropylene, cyclobutylene, cyclopentylene, cyclopentenylene, cyclohexylene, cyclohexenylene, cycloheptylene, cyclooctylene, decalinylene, octahydropentalenylene, octahydro-1H-indenylene, spiro[3.3]heptylene, spiro[2.5]octylene, spiro[3.5]nonylene, spiro[4.4]nonylene, spiro[4.5]decylene, spiro[5.5]undecylene, p-menthanylene, m-menthanylene, quinuclidinylene, adamantanylene, noradamantanylene, bornylene, bicyclo[2.2.1]heptanylene, 2-oxobicyclo[2.2.1]heptanylene, bicyclo[2.2.1]heptenylene, azetidinylene, oxetanylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, tetrahydrofuranylene, tetrahydropyranylene, tetrahydrothienylene, tetrahydrothiopyranylene, oxazolidinylene, thiazolidinylene, piperidinylene, piperazinylene, morpholinylene, thiomorpholinylene, dioxacyclohexylene, azacycloheptanylene, azacyclooctylene, diazacycloheptanylene, diazacyclooctylene, 3-azabicyclo[3.1.0]hexylene, 6-azabicyclo[3.1.1]heptanylene, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octylene, 3,8-diazabicyclo[3.2.1]octylene, 2,5-diazabicyclo[2.2.2]octylene, 3-azaspiro[5.5]undecylene, 7-azaspiro[3.5]nonylene, phenylene, naphthylene, furanylene, oxazolylene, isoxazolylene, oxadiazolylene, thienylene, thiazolylene, isothiazolylene, thiadiazolylene, pyrrolylene, imidazolylene, pyrazolylene, triazolylene, pyridylene, pyrimidinylene, pyridazinylene, pyrazinylene, indolylene, isoindolylene, benzofuranylene, isobenzofuranylene, benzothienylene, indazolylene, benzimidazolylene, benzoxazolylene, benzisoxazolylene, benzothiazolylene, benzisothiazolylene, benzotriazolylene, benzo[2,1,3]oxadiazolylene, benzo[2,1,3]thiadiazolylene, benzo[1,2,3]thiadiazolylene, quinolinylene, isoquinolinylene, naphthyridinylene, cinnolinylene, quinazolinylene, quinoxalinylene, phthalazinylene, pyrazolo[1,5-a]pyridylene, pyrazolo[1,5-a]pyrimidinylene, imidazo[1,2-a]pyridylene, 1H-pyrrolo[3,2-b]pyridylene, 1H-pyrrolo[2,3-b]pyridylene, 4H-fluoro[3,2-b]pyrrolylene, pyrrolo[2,1-b]thiazolylene or imidazo[2,1-b]thiazolylene, and (Rg7)n5 indicates that ring E is optionally substituted with n5 Rg7, n5 represents an integer of 0 to 8, and each Rg7, the same or different from each other, is independently selected from the group consisting of optionally deuterated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, NH2-C1-6 alkylene or any combination thereof; and Rf5 represents H, halogen, C1-3 alkyl, halogenated C1-3 alkyl, or wherein ring F represents: cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptanyl, 2-oxobicyclo[2.2.1]heptanyl, bicyclo[2.2.1]heptenyl, azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octyl, 2,5-diazabicyclo[2.2.2]octyl, 3-azaspiro[5.5]undecyl, 7-azaspiro[3.5]nonyl, phenyl, naphthyl, furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl or imidazo[2,1-b]thiazolyl, and (Rg8)n6 indicates that ring F is optionally substituted with n6 Rg8, n6 represents an integer of 0 to 8, and each Rg8, the same or different from each other, is independently selected from the group consisting of optionally deuterated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, NH2-C1-6 alkylene or any combination thereof.

14. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 6, wherein Ra1 represents: hydroxy, wherein when Ra1 represents hydroxy, X2 represents a bond; or adamantan-1-yl, adamantan-2-yl, adamantan-3-yl, adamantan-4-yl, adamantan-5-yl, adamantan-6-yl, adamantan-7-yl, adamantan-8-yl, adamantan-9-yl, adamantan-10-yl, noradamantan-1-yl, noradamantan-2-yl, noradamantan-3-yl, noradamantan-4-yl, noradamantan-5-yl, noradamantan-6-yl, noradamantan-7-yl, noradamantan-8-yl, noradamantan-9-yl, cubanyl, C5-15 spirocycloalkyl, bicyclo[2.2.2]octan-1-yl, bicyclo[2.2.2]octan-2-yl, 1,7,7-trimethylbicyclo[2.2.1]hept-2-yl, 1,7,7-trimethylbicyclo[2.2.1]hept-3-yl, 1,7,7-trimethylbicyclo[2.2.1]hept-4-yl, 1,7,7-trimethylbicyclo[2.

2. 1]hept-5-yl, 1,7,7-trimethylbicyclo[2.

2. 1]hept-6-yl, bicyclo[2.2.1]hept-2-yl, bicyclo[2.2.1]hept-3-yl, bicyclo[2.2.1]hept-4-yl, bicyclo[2.2.1]hept-5-yl, bicyclo[2.2.1]hept-6-yl, bicyclo[2.2.1]hept-5-en-2-yl, bicyclo[2.2.1]hept-5-en-3-yl, bicyclo[2.2.1]hept-5-en-7-yl, 7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl, 7,7-dimethyl-2-oxobicyclo[2.2.1]hept-3-yl, 7,7-dimethyl-2-oxobicyclo[2.2.1]hept-4-yl, 7,7-dimethyl-2-oxobicyclo[2.2.1]hept-5-yl, 7,7-dimethyl-2-oxobicyclo[2.2.1]hept-6-yl, p-menthanyl or m-menthanyl, with each group being independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof.

15. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 7 or 8, wherein Ra1 represents: azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 1,3-diazacycloheptanyl, 1,4-diazacycloheptanyl, 4,5-diazacycloheptanyl, 5- to 15-memberedbridged heterocyclyl (e.g., 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, diazabicyclo[3.2.1]octyl, diazabicyclo[2.2.2]octyl, 3,8-diazabicyclo[3.2.1]octan-3-yl, and 2,5-diazabicyclo[2.2.2]octan-2-yl), or 5- to 15-memberedazaspirocycloalkyl (e.g., 3-azaspiro[5.5]undecylene and 7-azaspiro[3.5]nonylene), with each group being independently optionally substituted with one or more substituents selected from the group consisting of: D, optionally deuterated C1-4 alkyl, optionally substituted C3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof, wherein the C3-15cycloalkyl, the 4-to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof.

16. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 9, wherein Ra1 represents: Ra1 represents hydroxy, and X2 represents a bond; or Ra1 represents: azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 1,3-diazacycloheptanyl, 1,4-diazacycloheptanyl, 4,5-diazacycloheptanyl, 5- to 15-memberedbridged heterocyclyl (e.g., 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, diazabicyclo[3.2.1]octyl, diazabicyclo[2.2.2]octyl, 3,8-diazabicyclo[3.2.1]octan-3-yl, and 2,5-diazabicyclo[2.2.2]octan-2-yl), or 5- to 15-memberedazaspirocycloalkyl (e.g., 3-azaspiro[5.5]undecylene and 7-azaspiro[3.5]nonylene), with each group being independently optionally substituted with one or more substituents selected from the group consisting of: D, optionally deuterated C1-4 alkyl, optionally substituted C3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof, wherein the C3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; or cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bomyl, bicyclo[2.2.1]heptanyl, 2-oxobicyclo[2.2.1]heptanyl or bicyclo[2.2.1]heptenyl, with each group being independently optionally substituted with one or more substituents selected from the group consisting of: D, optionally deuterated C1-4 alkyl, optionally substituted C3-iscycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof, wherein the C3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof.

17. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 10, wherein Ra2 represents: cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptanyl, 2-oxobicyclo[2.2.1]heptanyl or bicyclo[2.2.1]heptenyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof, and the C3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octyl, 2,5-diazabicyclo[2.2.2]octyl, 3-azaspiro[5.5]undecyl or 7-azaspiro[3.5]nonyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof, and the C3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; phenyl or naphthyl, wherein the phenyl or naphthyl is optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof, and the C3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; or furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl and imidazo[2,1-b]thiazolyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15cycloalkyl, optionally substituted 4-to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof, and the C3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof.

18. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 4, wherein X1 represents: wherein symbol # indicates the point of attachment to L1; and / or Ra1 represents hydroxy, or Ra1 represents: or 19. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 5, wherein X1 represents a bond, or X1 represents NH, N(CH3), O, S, ethynylene or vinylene, or X1 represents: wherein symbol # indicates the point of attachment to L1; and / or Ra1 represents:

20. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 6, wherein Ra1 represents hydroxy, and X2 represents a bond; or Ra1 represents:

21. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 7 or 8, wherein Ra1 represents:

22. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 9, wherein Ra1 represents:

23. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 10, wherein Ra2-X3- represents:

24. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 4, wherein L1 represents the following formula:         ##-(C(Ra1)(Ra2))m1-(Rd1(C(Ra3)(Ra4))m2)p1-;         ##-(C(Ra1)(Ra2))m1-(Rd1(C(Ra3)(Ra4))m2)p1-(Rd1(C(Ra5)(Ra6))m3)p2-;         ##-(C(Ra1)(Ra2))m1-(Rd1(C(Ra3)(Ra4))m2)p1-(Rd1(C(Ra5)(Ra6))m3)p2-(Rd1(C(Ra7)(Ra8))m4)p3-;         ##-(C(Ra1)(Ra2))m1-(Rd2(CXRa3)(Ra4))m2)p1-;         ##-(C(Ra1)(Ra2))m1-(Rd2(C(Ra3)(Ra4))m2)p1-(Rd2(C(Ra5)(Ra6))m3)p2-;         ##-((C(Ra1)(Ra2))m1-(Rd2(C(Ra3)(Ra4))m2)p1-(Rd2(C(Ra5)(Ra6))m3)p2-(Rd2(C (Ra7)(Ra8))m4)p3-;         ##-(C(Ra1)(Ra2))m1-(Rd1-Rd2-(C(Ra3)(Ra4))m2)p1-;         ##-(C(Ra1)(Ra2))m1-(Rd1(C(Ra3)(Ra4))m2)p1-(Rd2(C(Ra5)(Ra6))m3)p2-;         ##-(C(Ra1)(Ra2))m1-(Rd2-Rd1-(C(Ra3)(Ra4))m2)p1-; or         ##-(C(Ra1)(Ra2))m1-(Rd2(C(Ra3)(Ra4))m2)p1-(Rd1(C(Ra5)(Ra6))m3)p2-; wherein each Rd1 is independently selected from the group consisting of O, S, N(Rd3), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, wherein each Rd3 independently represents H or C1-3 alkyl; and each group Rd2 is independently selected from the group consisting of optionally substituted C3-15cycloalkylene, optionally substituted 4- to 15-membered heterocyclylene, optionally substituted C6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C2-6 alkenylene, C2-6 alkynylene or any combination thereof, wherein the C3-15cycloalkylene, the C6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH- or any combination thereof; Ra1, Ra2, Ra3, Ra4, Ra5, Ra6, Ra7 and Ra8 each independently represent H, deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH- or any combination thereof; symbol ## indicates the point of attachment to X1; and m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

25. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 5, wherein Li represents the structure of the following formula:         ##-(C(Ra1)(Ra2))m1-(Re2(C(Ra3)(Ra4))m2)p1-;         ##-(C(Ra1)(Ra2))m1-(Re2(C(Ra3)(Ra4))m2)p1-(Re2(C(Ra5)(Ra6))m3)p2-;         ##(C(Ra1)(Ra2))m1-(Re2(C(Ra3)(Ra4)))m2)p1-(Re2(C(Ra5))m3)p2-(Re2(C(Ra7)(Ra8))m4)p3-;         ##-(C(Ra1)(Ra2))m1-(Re3(C(Ra3)(Ra4))m2)p1-;         ##-(C(Ra1)(Ra2))m1-(Re3(C(Ra3)(Ra4))m2)p1-(Re3(C(Ra5)(Ra6))m3)p2-;         ##-(C(Ra1)(Ra2))m1(Re3(C(Ra3)(Ra4))m2)p1-(Re3(C(Ra5)(Ra6))m3)p2(Re3(C(Ra7)(Ra8))m4)p3-;         ##-(C(Ra1)(Ra2))m1-(Re2-Re3-(C(Ra3)(Ra4))m2)p1-;         ##-(C(Ra1-(Ra2))m1-(Re2(C(Ra3)(Ra4))m2)p1-(Re3(C(Ra5)(Ra6))m3)p2-;         ##-(C(Ra1-(Ra2))m1-(Re2(C(Ra3)(Ra4))m2)p1-; or         ##-(C(Ra1-(Ra2))m1-(Re3(C(Ra3)(Ra4))m2)p1-(Re2(C(Ra5)(Ra6))m3)p2-; wherein each Re2 is independently selected from the group consisting of O, S, N(Re4), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, wherein each Re4 independently represents H or C1-3 alkyl; and each group Re3 is independently selected from the group consisting of optionally substituted C3-15cycloalkylene, optionally substituted 4- to 15-membered heterocyclylene, optionally substituted C6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C2-6 alkenylene, C2-6 alkynylene or any combination thereof, wherein the C3-15cycloalkylene, the C6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH- or any combination thereof; Ra1, Ra2, Ra3, Ra4, Ra5, Ra6, Ra7 and Ra8 each independently represent H, deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH- or any combination thereof; symbol ## indicates the point of attachment to X1; and m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

26. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 24 or 25, wherein Li represents the structure of the following formula:         ##-(C(Ra1)(Ra2))m1-(O(C(Ra3)(Ra4))m2)p1-;         ##-(C(Ra1)(Ra2))m1-(O(C(Ra3)(Ra4))m2)p1-(O(C(Ra5)(Ra6))m3)p2-;         ##-(C(Ra1)(Ra2))m1-(O(C(Ra3)(Ra4))m2)p1-(O(C(Ra5)(Ra6))m3)p2-(O(C(Ra7)(Ra8))m4)p3-;         ##-(C(Ra1)(Ra2))m1-(N(Rg9)(C(Ra3)(Ra4))m2)p1-;         ##-(C(Ra1)(Ra2))m1-(N(Rg9)(C(Ra3)(Ra4))m2)p1-(N(Rg9)(C(Ra5)(Ra6))m3)p2-;         ##-(C(Ra1)(Ra2))m1-(N(Rg9)(C(Ra3)(Ra4))m2)p1-(N(Rg9)(C(Ra5)(Ra6))m3)p2-(N(Rg9)(C(Ra7)(Ra8))m4)p3-;         ##-(C(Ra1)(Ra2))m1-(C(O)NH-(C(Ra3)(Ra4))m2)p1-;         ##-(C(Ra1)(Ra2))m1-(C(O)NH-(C(Ra3)(Ra4))m2)p1-(C(O)NH-(C(Ra5)(Ra6))m3)p2-;         ##-(C(Ra1)(Ra2))m1-(C(O)NH-(C(Ra3)(Ra4))m2)p1-(C(O)NH-(C(Ra5)(Ra6))m3)p2-(C(O)NH- (C(Ra7)(Ra8))m4)p3-;         ##-(C(Ra1)(Ra2))m1-(C(O)NH-(C(Ra3)(Ra4))m2)p1-(O(C(Ra5)(Ra6))m3)p2-;         ##-(C(Ra1)(Ra2))m1-(C(O)NH-(C(Ra3)(Ra4))m2)p1-(O(C(Ra5)(Ra6))m3)p1-;         ##-(C(Ra1)(Ra2))m1-(NHC(O)(C(Ra3)(Ra4))m2)p1-;         ##-(C(Ra1)(Ra2))m1-(NHC(O)(C(Ra3)(Ra4))m2)p1-(O(C(Ra5)(Ra6))m3)p2-;         ##-(C(Ra1)(Ra2))m1-(NHC(O)(C(Ra3)(Ra4))m2)p1-(O(C(Ra5)(Ra6))m3)p2-(O(C(Ra7)(Ra8))m4)p3-;         ##-(C(Ra1)(Ra2))m1-(NHC(O)(C(Ra3)(Ra4))m2-(O(C(Ra5)(Ra6))m3)p1-;         ##-(C(Ra1)(Ra2))m1-NHC(O)NH-(C(Ra3)(Ra4))m2-;         ##(C(Ra1)(Ra2))m1-C(O)-(C(Ra3)(Ra4))m2-;         ##(C(Ra1)(Ra2))m1-C(S)-(C(Ra3)(Ra4))m2-;         ##-(C(Ra1)(Ra2))m1-S-(C(Ra3)(Ra4))m2-;         ##-(C(Ra1)(Ra2))m1-(C6-10 arylene-(C(Ra3)(Ra4))m2)p1-;         ##-(C(Ra1)(Ra2))m1-(C6-10 arylene-(C(Ra3)(Ra4))m2)p1-C6-10 arylene-(C(Ra5)(Ra6))m3-;         ##-(C(Ra1)(Ra2))m1-(4- to 15-membered heterocyclylene-(C(Ra3)(Raa))m2)p1-;         ##-(C(Ra1)(Ra2))m1-(4- to 15-membered heterocyclylene-(C(Ra3)(Raa))m2)p1-(4- to 15-membered heterocyclylene-(C(Ra5)(Ra6))m3)p2-;         ##-(C(Ra1)(Ra2))m1-(5- to 15-membered heteroarylene-(C(Ra3)(Ra4))m2)p1-;         ##-(C(Ra1)(Ra2))m1-(5- to 15-membered heteroarylene-(C(Ra3)(Ra4))m2)p1-(5- to 15-membered heteroarylene-(C(Ra5)(Ra6))m3)p2-;         ##-(C(Ra1)(R a2))m1-(C3-15cycloalkylene-(C(Ra3)(Ra4))m2)p1-; or         ##-(C(Ra1)(Ra2))m1-(C3-15cycloalkylene-(C(Ra3)(Ra4))m2)p1-(C3-15cycloalkylene-(C(Ra5)(Ra6))m3)p2-; wherein each Rg9 independently represents H or C1-3 alkyl; the C3-15cycloalkylene, the C6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, cyano or any combination thereof; Ra1, Ra2, Ra3, Ra4, Ra5, Ra6, Ra7 and Ra8each independently represent H, deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH- or any combination thereof; symbol ## indicates the point of attachment to X1; and m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

27. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 9, wherein L1 represents the structure of the following formula:         ##-(C(Ra1)(Ra2))m1-(R7(C(Ra1)(Ra4))m2)p1-;         ##-(C(Ra1)(Ra2))m1-(R7(C(Ra3)(Ra4))m2)p1-(R7(C(Ra5)(Ra6))m3)p2-;         ##-(C(Ra1)(Ra2))m1-(R7(C(Ra3)(Ra4))m2)p1-(R7(C(Ra5)(Ra6))m3)p2-(R7(C(Ra7)(Ra8))m4)p3-;         ##-(C(Ra1)(Ra2))m1-(R8(C(Ra3)(Ra4))m2)p1-;         ##-(C(Ra1)(Ra2))m1-(R8(C(Ra3)(Ra4))m2)p1-(R8(C(Ra5)(Ra6))m3)p2-;         #(C(Ra1)(Ra2))m1-(R8(C(Ra3)(Ra4))m2)p1-(R8(C(Ra5)(Ra6))m3)p2(R8(C(Ra7)(Ra8))m4)p3-;         ##-(C(Ra1)(Ra2))m1-(R7-R8-(C(Ra3)(Ra4))m2)p1-;         ##(C(Ra1)(Ra2))m1-(R7(C(Ra3)(Ra4))m2)p1-(R8(C(Ra5)(Ra6))m3)p2-;         ##(C(Ra1)(Ra2))m1-(R8-R7-(C(Ra3)(Ra4))m2)p1-; or         ##(C(Ra1)(Ra2))m1-(R8(C(Ra3)(Ra4))m2)p1-(R7(C(Ra5)(Ra6))m3)p2-; wherein each group R7 is independently selected from the group consisting of O, S, N(R9), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, wherein each R9 independently represents H or C1-3 alkyl; and each R8 is independently selected from the group consisting of C3-15cycloalkylene, 4- to 15-membered heterocyclylene, triazolylene or any combination thereof, wherein the C3-15cycloalkylene, the 4- to 15-membered heterocyclylene and the triazolylene are each independently optionally substituted with a substituent selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; Ra1, Ra2, Ra3, Ra4, Ra5, Ra6, Ra7 and Ra8 each independently represent H, deuterium, C1-4 alkyl, halogen, C3-6cycloalkyl or any combination thereof; symbol ## indicates the point of attachment to X1; and m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15; preferably, wherein L1 represents the structure of the following formula:         ##-(C(Ra1)(Ra2))m1-(O(C(Ra3)(Ra4))m2)p1-;         ##-(C(Ra1)(Ra2))m1-(O(C(Ra3)(Ra4))m2)p1-(O(C(Ra5)(Ra6))m3)p2-;         ##(C(Ra1)(Ra2))m1-(O(C(Ra3)(Ra4))m2)p1-(O(C(Ra5)(Ra6))m3)p2(O(C(Ra7)(Ra8))m4)p3-;         ##-(C(Ra1)(Ra2))m1-(N(R9)(C(Ra3)(Ra4))m2)p1-;         ##-(C(Ra1)(Ra2))m1-(N(R9)(C(Ra3)(Ra4))m2)p1-(N(R9)(C(Ra5)(Ra6))m3)p2-;         ##-(C(Ra1)(Ra2))m1-(N(R9)(C(Ra3)(Ra4))m2)p1-(N(R9)(C(Ra5)(Ra6))m3)p2-(N(R9)(C(Ra7)(Ra8))m4)p3-;         ##-(C(Ra1)(Ra2))m1-(C(O)NH-(C(Ra3)(Ra4))m2)p1-;         ##(C(Ra1)(Ra2))m1-(C(O)NH-(C(Ra3)(Ra4))m2)p1-(C(O)NH-(C(Ra5)(Ra6))m3)p2-;         ##(C(Ra1)(Ra2))m1-(C(O)NH-(C(Ra3)(Ra4))m2)p1-(C(O)NH-(C(Ra5)(Ra6))m3)p2-(C(O)NH-; (C(Ra7)(Ra8))m4)p3-;         ##(C(Ra1)(Ra2))m1-(C(O)NH-(C(Ra3)(Ra4))m2)p1-(O-(C(Ra5)(Ra6))m3)p2-;         ##(C(Ra1)(Ra2))m1-(C(O)NH-(C(Ra3)(Ra4))m2)(O(C(Ra5)(Ra6))m3)p1-;         ##(C(Ra1)(Ra2))m1-(NHC(O)-(C(Ra3)(Ra4))m2)p1-;         ##(C(Ra1)(Ra2))m1-(NHC(O)-(C(Ra3)(Ra4))m2)p1-(O(C(Ra5)(Ra6))m3)p2-;         ##(C(Ra1)(Ra2))m1-NHC(O)-(C(Ra3)(Ra4))m2)p1-(O-(C(Ra5)(Ra6))m3)p2-(O(C(Ra7)(Ra8))m4)p3-;         ##(C(Ra1)(Ra2))m1-NHC(O)-(C(Ra3)(Ra4))m2-(O(C(Ra5)(Ra6))m3)p1-;         ##-(C(Ra1)(Ra2))m1-NHC(O)NH-(C(Ra3)(Ra4))m2-;         ##-(C(Ra1)(Ra2))m1-C(O)-(C(Ra3)(Ra4))m2-;         ##(C(Ra1)(Ra2))m1-(C(S)-(C(Ra3)(Ra4))m2-;         ##-(C(Ra1)(Ra2))m1-S-(C(Ra3)(Ra4))m2-;         ##-(C(Ra1)(Ra2))m1-(4- to 15-membered heterocyclylene-(C(Ra3)(Raa))m2)p1-;         ##-(C(Ra1)(Ra2))m1-(4- to 15-membered heterocyclylene-(C(Ra3)(Ra4))m2)p1-(4- to 15-membered heterocyclylene-(C(Ra5)(Ra6))m3)p2-;         ##-(C(Ra1)(Ra2))m1-( triazolylene -(C(Ra3)(Ra4))m2)p1-;         ##-(C(Ra1)(Ra2))m1-( triazolylene -(C(Ra3)(Ra4))m2)p1-( triazolylene -(C(Ra5)(Ra6))m3)p2-;         ##-(C(Ra1)(Ra2))m1-(C3-15cycloalkylene-(C(Ra3)(Ra4))m2)p1-; or         ##-(C(Ra1)(Ra2))m1-(C3-15cycloalkylene-(C(Ra3)(Ra4))m2)p1-(C3-15cycloalkylene-(C(Ra5)(Ra6))m3)p2-; wherein each R9 independently represents H or C1-3 alkyl; the C3-15cycloalkylene, the 4- to 15-membered heterocyclylene and the triazolylene are each independently optionally substituted with a substituent selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH- or any combination thereof; Ra1, Ra2, Ra3, Ra4, Ra5, Ra6, Ra7 and Ra8 each independently represent H, deuterium, C1-4 alkyl, halogen, C3-6cycloalkyl or any combination thereof; symbol ## indicates the point of attachment to X1; and m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

28. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 26 or 27, wherein L1 represents the following group: ##-CH2-O-CH2-, ##-CH2-O-(CH2)2-, ##-(CH2)1-O-(CH2)3-, ##-(CH2)1-O-(CH2)4-, ##-(CH2)1-O-(CH2)5-, ##-(CH2)1-O-(CH2)6-, ##-(CH2)1-O-(CH2)7-, ##-(CH2)1-O-(CH2)8-, ##-(CH2)1-O-(CH2)9-, ##-(CH2)1-O-(CH2)10-, ##-(CH2)2-O-(CH2)1-, ##-(CH2)2-O-(CH2)2-, ##-(CH2)2-O-(CH2)3-, ##-(CH2)2-O-(CH2)4-, ##-(CH2)2-O-(CH2)5-, ##-(CH2)2-O-(CH2)6-, ##-(CH2)2-O-(CH2)7-, ##-(CH2)2-O-(CH2)8-, ##-(CH2)2-O-(CH2)9-, ##-(CH2)2-O-(CH2)10-, ##-(CH2)2-O-(CH2)11-, ##-(CH2)2-O-(CH2)12-, ##-(CH2)3-O-(CH2)1-, ##-(CH2)3-O-(CH2)2-, ##-(CH2)3-O-(CH2)3-, ##-(CH2)3-O-(CH2)4-, ##-(CH2)3-O-(CH2)5-, ##-(CH2)3-O-(CH2)6-, ##-(CH2)3-O-(CH2)7-, ##-(CH2)4-O-(CH2)1-, ##-(CH2)4-O-(CH2)2-, ##-(CH2)4-O-(CH2)3-, ##-(CH2)4-O-(CH2)4-, ##-(CH2)4-O-(CH2)5-, ##-(CH2)4-O-(CH2)6-, ##-(CH2)5-O-(CH2)1-, ##-(CH2)5-O-(CH2)2-, ##-(CH2)5-O-(CH2)3-, ##-(CH2)5-O-(CH2)4-, ##-(CH2)5-O-(CH2)5-, ##-(CH2)6-O-(CH2)1-, ##-(CH2)6-O-(CH2)2-, ##-(CH2)6-O-(CH2)3-, ##-(CH2)6-O-(CH2)4-, ##-(CH2)7-O-(CH2)1-, ##-(CH2)7-O-(CH2)2-, ##-(CH2)7-O-(CH2)3-, ##-(CH2)8-O-(CH2)1-, ##-(CH2)8-O-(CH2)2-, ##-CH(CH3)-O-(CH2)1-, ##-CH(CH3)-O-(CH2)2-, 99-CH(CH3)-O-(CH2)3-, 99-CH(CH3)-O-(CH2)4-, ##-CH(CH3)-O-(CH2)5-, ##-CH(CH3)-O-(CH2)6-, ##-CH(CH3)-O-(CH2)7-, ##-CH(CH3)-O-(CH2)8-, ##-CH(CH3)-O-(CH2)9-, ##-CH(CH3)-O-(CH2)10-, ##-CH2-(O(CH2)2)2-, ##-CH2-(O(CH2)2)3-, ##-CH2-(O(CH2)2)4-, ##-CH2-(O(CH2)2)5-, ##-CH2-(O(CH2)2)6-, ##-CH2-(O(CH2)2)7-, ##-CH2-(O(CH2)2)8-, ##-CH2-(O(CH2)2)9-, ##-CH2-(O(CH2)2)10-, ##-CH2-(O(CH2)2)1-OCH2-, ##-CH2-(O(CH2)2)2-OCH2-, ##-CH2-(O(CH2)2)3-OCH2-, ##-CH2-(O(CH2)2)4-OCH2-, ##-CH2-(O(CH2)2)5-OCH2-, ##-CH2-(O(CH2)2)6-OCH2-, ##-CH2-(O(CH2)2)7-OCH2-, ##-CH2-(O(CH2)2)8-OCH2-, ##-CH2-(O(CH2)2)9-OCH2-, ##-CH2-(O(CH2)2)10-OCH2-, ##-(CH2)2-(O(CH2)2)2-, ##-(CH2)2-(O(CH2)2)3-, ##-(CH2)2-(O(CH2)2)4-, ##-(CH2)2-(O(CH2)2)5-, ##-(CH2)2-(O(CH2)2)6-, ##-(CH2)2-(O(CH2)2)7-, ##-(CH2)2-(O(CH2)2)8-, ##-(CH2)2-(O(CH2)2)9-, ##-(CH2)2-(O(CH2)2)10-, ##-(CH2)3-(O(CH2)2)2-, ##-(CH2)3-(O(CH2)2)3-, ##-(CH2)3-(O(CH2)2)4-, ##-(CH2)3-(O(CH2)2)5-, ##-(CH2)3-(O(CH2)2)6-, ##-(CH2)3-(O(CH2)2)7-, ##-(CH2)3-(O(CH2)2)8-, ##-(CH2)3-(O(CH2)2)9-, ##-(CH2)3-(O(CH2)2)10-, ##-(CH2)4-(O(CH2)2)2-, ##-(CH2)4-(O(CH2)2)3-, ##-(CH2)4-(O(CH2)2)4-, ##-(CH2)4-(O(CH2)2)5-, ##-(CH2)4-(O(CH2)2)6-, ##-(CH2)4-(O(CH2)2)7-, ##-(CH2)4-(O(CH2)2)8-, ##-(CH2)4-(O(CH2)2)9-, ##-(CH2)4-(O(CH2)2)10-, ##-CH2-(O(CH2)3)2-, ##-CH2-(O(CH2)3)3-, ##-CH2-(O(CH2)3)4-, ##-CH2-(O(CH2)3)5-, ##-CH2-(O(CH2)3)6-, ##-CH2-(O(CH2)3)7-, ##-CH2-(O(CH2)3)8-, ##-CH2-(O(CH2)3)9-, ##-CH2-(O(CH2)3)10-, ##-(CH2)2-(O(CH2)3)2-, ##-(CH2)2-(O(CH2)3)3-, ##-(CH2)2-(O(CH2)3)4-, ##-(CH2)2-(O(CH2)3)5-, ##-(CH2)2-(O(CH2)3)6-, ##-(CH2)2-(O(CH2)3)7-, ##-(CH2)2-(O(CH2)3)8-, ##-(CH2)2-(O(CH2)3)9-, ##-(CH2)2-(O(CH2)3)10-, ##-(CH2)3-(O(CH2)3)2-, ##-(CH2)3-(O(CH2)3)3-, ##-(CH2)3-(O(CH2)3)4-, ##-(CH2)3-(O(CH2)3)5-, ##-(CH2)3-(O(CH2)3)6-, ##-(CH2)3-(O(CH2)3)7-, ##-(CH2)3-(O(CH2)3)8-, ##-(CH2)3-(O(CH2)3)9-, ##-(CH2)3-(O(CH2)3)10-, ##-CH2-O-(CH2)2-O-(CH2)3-, ##-CH2-(O(CH2)2)2-(O(CH2)3)2-, ##-CH2-(O(CH2)2)3-(O(CH2)3)3-, ##-CH2-(O(CH2)2)4-(O(CH2)3)4-, ##-CH2-(O(CH2)2)5-(O(CH2)3)5-, ##-CH2-(O(CH2)2)6-(O(CH2)3)6-, ##-(CH2)2-O-(CH2)2-O-(CH2)3-, ##-(CH2)2-(O(CH2)2)2-(O(CH2)3)2-, ##-(CH2)2-(O(CH2)2)3-(O(CH2)3)3-, ##-(CH2)2-(O(CH2)2)4-(O(CH2)3)4-, ##-(CH2)2-(O(CH2)2)5-(O(CH2)3)5-, ##-(CH2)2-(O(CH2)2)6-(O(CH2)3)6-, ##-(CH2)3-O-(CH2)2-O-(CH2)3-, ##-(CH2)3-(O(CH2)2)2-(O(CH2)3)2-, ##-(CH2)3-(O(CH2)2)3-(O(CH2)3)3-, ##-(CH2)3-(O(CH2)2)4-(O(CH2)3)4-, ##-(CH2)3-(O(CH2)2)5-(O(CH2)3)5-, ##-(CH2)3-(O(CH2)2)6-(O(CH2)3)6-, ##-CH2-O-(CH2)3-O-(CH2)2-, ##-CH2-(O(CH2)3)2-(O(CH2)2)2-, ##-CH2-(O(CH2)3)3-(O(CH2)2)3-, ##-CH2-(O(CH2)3)4-(O(CH2)2)4-, ##-CH2-(O(CH2)3)5-(O(CH2)2)5-, ##-CH2-(O(CH2)3)6-(O(CH2)2)6-, ##-(CH2)2-O-(CH2)3-O-(CH2)2-, ##-(CH2)2-(O(CH2)3)2-(O(CH2)2)2-, ##-(CH2)2-(O(CH2)3)3-(O(CH2)2)3-, ##-(CH2)2-(O(CH2)3)4-(O(CH2)2)4-, ##-(CH2)2-(O(CH2)3)5-(O(CH2)2)5-, ##-(CH2)2-(O(CH2)3)6-(O(CH2)2)6-, ##-(CH2)3-O-(CH2)3-O-(CH2)2-, ##-(CH2)3-(O(CH2)3)2-(O(CH2)2)2-, ##-(CH2)3-(O(CH2)3)3-(O(CH2)2)3-, ##-(CH2)3-(O(CH2)3)4-(O(CH2)2)4-, ##-(CH2)3-(O(CH2)3)5-(O(CH2)2)5-, ##-(CH2)3-(O(CH2)3)6-(O(CH2)2)6-, ##-CH2-O-(CH2)2-O-CH2-, ##-(CH2)2-O-(CH2)2-O-CH2-, ##-(CH2)2-(O(CH2)2)2-O-(CH2)3-, ##-(CH2)2-(O(CH2)2)3-O-(CH2)3-, ##-(CH2)2-(O(CH2)2)4-O-(CH2)3-, ##-(CH2)5-(O(CH2)2)2-O-(CH2)5-, ##-(CH2)5-(O(CH2)2)2-O-(CH2)6-, ##-CH2-C(O)-CH2-, ##-CH2-C(O)-(CH2)2-, ##-(CH2)1-C(O)-(CH2)3-, ##-(CH2)1-C(O)-(CH2)4-, ##-(CH2)1-C(O)-(CH2)5-, ##-(CH2)1-C(O)-(CH2)6-, ##-(CH2)1-C(O)-(CH2)7-, ##-(CH2)1-C(O)-(CH2)8-, ##-(CH2)1-C(O)-(CH2)9-, ##-(CH2)1-C(O)-(CH2)10-, ##-(CH2)2-C(O)-(CH2)1-, ##-(CH2)2-C(O)-(CH2)2-, ##-(CH2)2-C(O)-(CH2)3-, ##-(CH2)2-C(O)-(CH2)4-, ##-(CH2)2-C(O)-(CH2)5-, ##-(CH2)2-C(O)-(CH2)6-, ##-(CH2)2-C(O)-(CH2)7-, ##-(CH2)2-C(O)-(CH2)8-, ##-(CH2)2-C(O)-(CH2)9-, ##-(CH2)2-C(O)-(CH2)10-, ##-(CH2)2-C(O)-(CH2)11-, ##-(CH2)2-C(O)-(CH2)12-, ##-(CH2)3-C(O)-(CH2)1-, ##-(CH2)3-C(O)-(CH2)2-, ##-(CH2)3-C(O)-(CH2)3-, ##-(CH2)3-C(O)-(CH2)4-, ##-(CH2)3-C(O)-(CH2)5-, ##-(CH2)3-C(O)-(CH2)6-, ##-(CH2)3-C(O)-(CH2)7-, ##-(CH2)4-C(O)-(CH2)1-, ##-(CH2)4-C(O)-(CH2)2-, ##-(CH2)4-C(O)-(CH2)3-, ##-(CH2)4-C(O)-(CH2)4-, ##-(CH2)4-C(O)-(CH2)5-, ##-(CH2)a-C(O)-(CH2)6-, ##-(CH2)5-C(O)-(CH2)1-, ##-(CH2)5-C(O)-(CH2)2-, ##-(CH2)5-C(O)-(CH2)3-, ##-(CH2)5-C(O)-(CH2)4-, ##-(CH2)5-C(O)-(CH2)5-, ##-(CH2)6-C(O)-(CH2)1-, ##-(CH2)6-C(O)-(CH2)2-, ##-(CH2)6-C(O)-(CH2)3-, ##-(CH2)6-C(O)-(CH2)4-, ##-(CH2)7-C(O)-(CH2)1-, ##-(CH2)7-C(O)-(CH2)2-, ##-(CH2)7-C(O)-(CH2)3-, ##-(CH2)8-C(O)-(CH2)1-, ##-(CH2)8-C(O)-(CH2)2-, ##-CH2-S-CH2-, ##-CH2-S-(CH2)2-, ##-(CH2)1-S-(CH2)3-, ##-(CH2)1-S-(CH2)4-, ##-(CH2)1-S-(CH2)5-, ##-(CH2)1-S-(CH2)6-, ##-(CH2)1-S-(CH2)7-, ##-(CH2)1-S-(CH2)8-, ##-(CH2)1-S-(CH2)9-, ##-(CH2)1-S-(CH2)10-, ##-(CH2)2-S-(CH2)1-, ##-(CH2)2-S-(CH2)2-, ##-(CH2)2-S-(CH2)3-, ##-(CH2)2-S-(CH2)4-, ##-(CH2)2-S-(CH2)5-, ##-(CH2)2-S-(CH2)6-, ##-(CH2)2-S-(CH2)7-, ##-(CH2)2-S-(CH2)8-, ##-(CH2)2-S-(CH2)9-, ##-(CH2)2-S-(CH2)10-, ##-(CH2)2-S-(CH2)11-, ##-(CH2)2-S-(CH2)12-, ##-(CH2)3-S-(CH2)1-, ##-(CH2)3-S-(CH2)2-, ##-(CH2)3-S-(CH2)3-, ##-(CH2)3-S-(CH2)4-, ##-(CH2)3-S-(CH2)5-, ##-(CH2)3-S-(CH2)6-, ##-(CH2)3-S-(CH2)7-, ##-(CH2)4-S-(CH2)1-, ##-(CH2)4-S-(CH2)2-, ##-(CH2)4-S-(CH2)3-, ##-(CH2)4-S-(CH2)4-, ##-(CH2)4-S-(CH2)5-, ##-(CH2)4-S-(CH2)6-, ##-(CH2)5-S-(CH2)1-, ##-(CH2)5-S-(CH2)2-, ##-(CH2)5-S-(CH2)3-, ##-(CH2)5-S-(CH2)4-, ##-(CH2)5-S-(CH2)5-, ##-(CH2)6-S-(CH2)1-, ##-(CH2)6-S-(CH2)2-, ##-(CH2)6-S-(CH2)3-, ##-(CH2)6-S-(CH2)4-, ##-(CH2)7-S-(CH2)1-, ##-(CH2)7-S-(CH2)2-, ##-(CH2)7-S-(CH2)3-, ##-(CH2)8-S-(CH2)1-, ##-(CH2)8-S-(CH2)2-, ##-CH2-C(S)-CH2-, ##-CH2-C(S)-(CH2)2-, ##-(CH2)1-C(S)-(CH2)3-, ##-(CH2)1-C(S)-(CH2)4-, ##-(CH2)1-C(S)-(CH2)5-, ##-(CH2)1-C(S)-(CH2)6-, ##-(CH2)1-C(S)-(CH2)7-, ##-(CH2)1-C(S)-(CH2)8-, ##-(CH2)1-C(S)-(CH2)9-, ##-(CH2)1-C(S)-(CH2)10-, ##-(CH2)2-C(S)-(CH2)1-, ##-(CH2)2-C(S)-(CH2)2-, ##-(CH2)2-C(S)-(CH2)3-, ##-(CH2)2-C(S)-(CH2)4-, ##-(CH2)2-C(S)-(CH2)5-, ##-(CH2)2-C(S)-(CH2)6-, ##-(CH2)2-C(S)-(CH2)7-, ##-(CH2)2-C(S)-(CH2)8-, ##-(CH2)2-C(S)-(CH2)9-, ##-(CH2)2-C(S)-(CH2)10-, ##-(CH2)2-C(S)-(CH2)11-, ##-(CH2)2-C(S)-(CH2)12-, ##-(CH2)3-C(S)-(CH2)1-, ##-(CH2)3-C(S)-(CH2)2-, ##-(CH2)3-C(S)-(CH2)3-, ##-(CH2)3-C(S)-(CH2)4-, ##-(CH2)3-C(S)-(CH2)5-, ##-(CH2)3-C(S)-(CH2)6-, ##-(CH2)3-C(S)-(CH2)7-, ##-(CH2)4-C(S)-(CH2)1-, ##-(CH2)4-C(S)-(CH2)2-, ##-(CH2)4-C(S)-(CH2)3-, ##-(CH2)4-C(S)-(CH2)4-, ##-(CH2)4-C(S)-(CH2)5-, ##-(CH2)4-C(S)-(CH2)6-, ##-(CH2)5-C(S)-(CH2)1-, ##-(CH2)5-C(S)-(CH2)2-, ##-(CH2)5-C(S)-(CH2)3-, ##-(CH2)5-C(S)-(CH2)4-, ##-(CH2)5-C(S)-(CH2)5-, ##-(CH2)6-C(S)-(CH2)1-, ##-(CH2)6-C(S)-(CH2)2-, ##-(CH2)6-C(S)-(CH2)3-, ##-(CH2)6-C(S)-(CH2)4-, ##-(CH2)7-C(S)-(CH2)I-, ##-(CH2)7-C(S)-(CH2)2-, ##-(CH2)7-C(S)-(CH2)3-, ##-(CH2)8-C(S)-(CH2)1-, ##-(CH2)8-C(S)-(CH2)2-, ##-CH2-C(O)O-CH2-, ##-CH2-C(O)O-(CH2)2-, ##-(CH2)1-C(O)O-(CH2)3-, ##-(CH2)1-C(O)O-(CH2)4-, ##-(CH2)1-C(O)O-(CH2)5-, ##-(CH2)1-C(O)O-(CH2)6-, ##-(CH2)1-C(O)O-(CH2)7-, ##-(CH2)1-C(O)O-(CH2)8-, ##-(CH2)1-C(O)O-(CH2)9-, ##-(CH2)1-C(O)O-(CH2)10-, ##-(CH2)2-C(O)O-(CH2)1-, ##-(CH2)2-C(O)O-(CH2)2-, ##-(CH2)2-C(O)O-(CH2)3-, ##-(CH2)2-C(O)O-(CH2)4-, ##-(CH2)2-C(O)O-(CH2)5-, ##-(CH2)2-C(O)O-(CH2)6-, ##-(CH2)2-C(O)O-(CH2)7-, ##-(CH2)2-C(O)O-(CH2)8-, ##-(CH2)2-C(O)O-(CH2)9-, ##-(CH2)2-C(O)O-(CH2)10-, ##-(CH2)2-C(O)O-(CH2)11-, ##-(CH2)2-C(O)O-(CH2)12-, ##-(CH2)3-C(O)O-(CH2)1-, ##-(CH2)3-C(O)O-(CH2)2-, ##-(CH2)3-C(O)O-(CH2)3-, ##-(CH2)3-C(O)O-(CH2)4-, ##-(CH2)3-C(O)O-(CH2)5-, ##-(CH2)3-C(O)O-(CH2)6-, ##-(CH2)3-C(O)O-(CH2)7-, ##-(CH2)4-C(O)O-(CH2)1-, ##-(CH2)4-C(O)O-(CH2)2-, ##-(CH2)4-C(O)O-(CH2)3-, ##-(CH2)4-C(O)O-(CH2)4-, ##-(CH2)4-C(O)O-(CH2)5-, ##-(CH2)4-C(O)O-(CH2)6-, ##-(CH2)5-C(O)O-(CH2)1-, ##-(CH2)5-C(O)O-(CH2)2-, ##-(CH2)5-C(O)O-(CH2)3-, ##-(CH2)5-C(O)O-(CH2)4-, ##-(CH2)5-C(O)O-(CH2)5-, ##-(CH2)6-C(O)O-(CH2)1-, ##-(CH2)6-C(O)O-(CH2)2-, ##-(CH2)6-C(O)O-(CH2)3-, ##-(CH2)6-C(O)O-(CH2)4-, ##-(CH2)7-C(O)O-(CH2)1-, ##-(CH2)7-C(O)O-(CH2)2-, ##-(CH2)7-C(O)O-(CH2)3-, ##-(CH2)8-C(O)O-(CH2)1-, ##-(CH2)8-C(O)O-(CH2)2-, ##-CH2-OC(O)-CH2-, ##-CH2-OC(O)-(CH2)2-, ##-(CH2)1-OC(O)-(CH2)3-, ##-(CH2)1-OC(O)-(CH2)4-, ##-(CH2)1-OC(O)-(CH2)5-, ##-(CH2)1-OC(O)-(CH2)6-, ##-(CH2)1-OC(O)-(CH2)7-, ##-(CH2)1-OC(O)-(CH2)8-, ##-(CH2)1-OC(O)-(CH2)9-, ##-(CH2)1-OC(O)-(CH2)10-, ##-(CH2)2-OC(O)-(CH2)1-, ##-(CH2)2-OC(O)-(CH2)2-, ##-(CH2)2-OC(O)-(CH2)3-, ##-(CH2)2-OC(O)-(CH2)4-, ##-(CH2)2-OC(O)-(CH2)5-, ##-(CH2)2-OC(O)-(CH2)6-, ##-(CH2)2-OC(O)-(CH2)7-, ##-(CH2)2-OC(O)-(CH2)8-, ##-(CH2)2-OC(O)-(CH2)9-, ##-(CH2)2-OC(O)-(CH2)10-, ##-(CH2)2-OC(O)-(CH2)11-, ##-(CH2)2-OC(O)-(CH2)12-, ##-(CH2)3-OC(O)-(CH2)1-, ##-(CH2)3-OC(O)-(CH2)2-, ##-(CH2)3-OC(O)-(CH2)3-, ##-(CH2)3-OC(O)-(CH2)4-, ##-(CH2)3-OC(O)-(CH2)5-, ##-(CH2)3-OC(O)-(CH2)6-, ##-(CH2)3-OC(O)-(CH2)7-, ##-(CH2)4-OC(O)-(CH2)1-, ##-(CH2)4-OC(O)-(CH2)2-, ##-(CH2)4-OC(O)-(CH2)3-, ##-(CH2)4-OC(O)-(CH2)4-, ##-(CH2)4-OC(O)-(CH2)5-, ##-(CH2)4-OC(O)-(CH2)6-, ##-(CH2)5-OC(O)-(CH2)1-, ##-(CH2)5-OC(O)-(CH2)2-, ##-(CH2)5-OC(O)-(CH2)3-, ##-(CH2)5-OC(O)-(CH2)4-, ##-(CH2)5-OC(O)-(CH2)5-, ##-(CH2)6-OC(O)-(CH2)1-, ##-(CH2)6-OC(O)-(CH2)2-, ##-(CH2)6-OC(O)-(CH2)3-, ##-(CH2)6-OC(O)-(CH2)4-, ##-(CH2)7-OC(O)-(CH2)1-, ##-(CH2)7-OC(O)-(CH2)2-, ##-(CH2)7-OC(O)-(CH2)3-, ##-(CH2)8-OC(O)-(CH2)1-, ##-(CH2)8-OC(O)-(CH2)2-, ##-(CH2)1-N(Rg10)-(CH2)1-, ##-(CH2)1-N(Rg10)-(CH2)2-, ##-(CH2)1-N(Rg10)-(CH2)3-, ##-(CH2)1-N(Rg10)-(CH2)4-, ##-(CH2)1-N(Rg10)-(CH2)5-, ##-(CH2)1-N(Rg10)-(CH2)6-, ##-(CH2)1-N(Rg10)-(CH2)7-, ##-(CH2)1-N(Rg10)-(CH2)8-, ##-(CH2)1-N(Rg10)-(CH2)9-, ##-(CH2)1-N(Rg10)-(CH2)10-, ##-(CH2)2-N(Rg10)-(CH2)1-, ##-(CH2)2-N(Rg10)-(CH2)2-, ##-(CH2)2-N(Rg10)-(CH2)3-, ##-(CH2)2-N(Rg10)-(CH2)4-, ##-(CH2)2-N(Rg10)-(CH2)5-, ##-(CH2)2-N(Rg10)-(CH2)6-, ##-(CH2)2-N(Rg10)-(CH2)7-, ##-(CH2)2-N(Rg10)-(CH2)8-, ##-(CH2)2-N(Rg10)-(CH2)9-, ##-(CH2)2-N(Rg10)-(CH2)10-, ##-(CH2)2-N(Rg10)-(CH2)11-, ##-(CH2)2-N(Rg10)-(CH2)12-, ##-(CH2)3-N(Rg10)-(CH2)1-, ##-(CH2)3-N(Rg10)-(CH2)2-, ##-(CH2)3-N(Rg10)-(CH2)3-, ##-(CH2)4-N(Rg10)-(CH2)1-, ##-(CH2)4-N(Rg10)-(CH2)2-, ##-(CH2)4-N(Rg10)-(CH2)3-, ##-(CH2)4-N(Rg10)-(CH2)4-, ##-(CH2)5-N(Rg10)-(CH2)1-, ##-(CH2)5-N(Rg10)-(CH2)2-, ##-(CH2)5-N(Rg10)-(CH2)3-, ##-(CH2)5-N(Rg10)-(CH2)4-, ##-(CH2)5-N(Rg10)-(CH2)5-, ##-(CH2)6-N(Rg10)-(CH2)1-, ##-(CH2)6-N(Rg10)-(CH2)2-, ##-(CH2)6-N(Rg10)-(CH2)3-, ##-(CH2)7-N(Rg10)-(CH2)1-, ##-(CH2)7-N(Rg10)-(CH2)2-, ##-(CH2)7-N(Rg10)-(CH2)3-, ##-(CH2)8-N(Rg10)-(CH2)1-, ##-(CH2)8-N Rg10)-(CH2)2-, ##-(CH2)8-N(Rg10)-(CH2)3-, ##-CH(CH3)-N(Rg10)-(CH2)1-, ##-CH(CH3)-N(Rg10)-(CH2)2-, ##-CH(CH3)-N(Rg10)-(CH2)3-, ##-CH(CH3)-N(Rg10)-(CH2)4-, ##-CH(CH3)-N(Rg10)-(CH2)5-, ##-CH(CH3)-N(Rg10)-(CH2)6-, ##-CH(CH3)-N(Rg10)-(CH2)7-, ##-CH(CH3)-N(Rg10)-(CH2)8-, ##-CH(CH3)-N(Rg10)-(CH2)9-, ##-CH(CH3)-N(Rg10)-(CH2)10-, ##-CH2C(O)NHCH2-, ##-(CH2)2C(O)NH(CH2)2-, ##-(CH2)2C(O)NH(CH2)3-, ##-(CH2)2C(O)NH(CH2)4-, ##-(CH2)2C(O)NH(CH2)5-, ##-(CH2)3C(O)NH(CH2)3-, ##-(CH2)3C(O)NH(CH2)4-, ##-(CH2)4C(O)NH(CH2)4-, ##-(CH2)5C(O)NH(CH2)5-, ##-(CH2)6C(O)NH(CH2)7-, ##-(CH2)6C(O)NH(CH2)6-, ##-(CH2)7C(O)NH(CH2)7-, ##-(CH2)8C(O)NH(CH2)8, ##-(CH2)9C(O)NH(CH2)9-, ##-(CH2)10C(O)NH(CH2)10-, ##-(CH2)2C(O)NH(CH2)2-O-(CH2)2-, ##-CH2NHC(O)CH2-, ##-(CH2)2NHC(O)(CH2)2-, ##-(CH2)2NHC(O)(CH2)3-, ##-(CH2)2NHC(O)(CH2)4-, ##-(CH2)2NHC(O)(CH2)5-, ##-(CH2)3NHC(O)(CH2)3-, ##-(CH2)3NHC(O)(CH2)4-, ##-(CH2)4NHC(O)(CH2)4-, ##-(CH2)5NHC(O)(CH2)5-, ##-(CH2)6NHC(O)(CH2)7-, ##-(CH2)6NHC(O)(CH2)6-, ##-(CH2)7NHC(O)(CH2)7-, ##-(CH2)8NHC(O)(CH2)8, ##-(CH2)9NHC(O)(CH2)9-, ##-(CH2)10NHC(O)(CH2)10-, ##-(CH2)4NHC(O)(CH2)8-, ##-(CH2)2NHC(O)(CH2)2-O-(CH2)2-, ##-(CH2)4NHC(O)CH2-, ##-CH2-piperidinylene-CH2-, ##-CH2-piperidinylene-(CH2)2-, ##-CH2-piperidinylene-(CH2)3-, ##-CH2-piperidinylene-(CH2)4-, ##-CH2-piperidinylene-(CH2)5-, ##-CH2-piperidinylene-(CH2)6-, ##-CH2-piperidinylene-(CH2)7-, ##-CH2-piperidinylene-(CH2)8-, ##-(CH2)2-piperidinylene-(CH2)1-, ##-(CH2)2-piperidinylene-(CH2)2-, ##-(CH2)2-piperidinylene-(CH2)3-, ##-(CH2)2-piperidinylene-(CH2)4-, ##-(CH2)2-piperidinylene-(CH2)5-, ##-(CH2)2-piperidinylene-(CH2)6-, ##-(CH2)2-piperidinylene-(CH2)7-, ##-(CH2)2-piperidinylene-(CH2)8-, ##-(CH2)3-piperidinylene-CH2-, ##-(CH2)3-piperidinylene-(CH2)2-, ##-(CH2)3-piperidinylene-(CH2)3-, ##-(CH2)3-piperidinylene-(CH2)4-, ##-(CH2)3-piperidinylene-(CH2)5-, ##-(CH2)3-piperidinylene-(CH2)6-, ##-(CH2)3-piperidinylene-(CH2)7-, ##-(CH2)3-piperidinylene-(CH2)8-, ##-(CH2)4-piperidinylene-CH2-, ##-(CH2)4-piperidinylene-(CH2)2-, ##-(CH2)4-piperidinylene-(CH2)3-, ##-(CH2)4-piperidinylene-(CH2)4-, ##-(CH2)4-piperidinylene-(CH2)5-, ##-(CH2)4-piperidinylene-(CH2)6-, ##-(CH2)4-piperidinylene-(CH2)7-, ##-(CH2)4-piperidinylene-(CH2)8-, ##-(CH2)5-piperidinylene-(CH2)1-, ##-(CH2)5-piperidinylene-(CH2)2-, ##-(CH2)5-piperidinylene-(CH2)3-, ##-(CH2)5-piperidinylene-(CH2)4-, ##-(CH2)5-piperidinylene-(CH2)5-, ##-(CH2)5-piperidinylene-(CH2)6-, ##-(CH2)5-piperidinylene-(CH2)7-, ##-(CH2)5-piperidinylene-(CH2)8-, ##-(CH2)6-piperidinylene-(CH2)1-, ##-(CH2)6-piperidinylene-(CH2)2-, ##-(CH2)6-piperidinylene-(CH2)3-, ##-(CH2)6-piperidinylene-(CH2)4-, ##-(CH2)6-piperidinylene-(CH2)5-, ##-(CH2)6-piperidinylene-(CH2)6-, ##-(CH2)6-piperidinylene-(CH2)7-, ##-(CH2)6-piperidinylene-(CH2)8-, ##-(CH2)7-piperidinylene-(CH2)1-, ##-(CH2)7-piperidinylene-(CH2)2-, ##-(CH2)7-piperidinylene-(CH2)3-, ##-(CH2)7-piperidinylene-(CH2)4-, ##-(CH2)7-piperidinylene-(CH2)s-, ##-(CH2)8-piperidinylene-CH2-, ##-(CH2)8-piperidinylene-(CH2)2-, ##-(CH2)8-piperidinylene-(CH2)3-, ##-(CH2)8-piperidinylene-(CH2)4-, ##-(CH2)8-piperidinylene-(CH2)5-, ##-(CH2)8-piperidinylene-(CH2)6-, ##-(CH2)8-piperidinylene-(CH2)7-, ##-(CH2)8-piperidinylene-(CH2)8-, ##-CH2-piperazinylene-CH2-, ##-CH2-piperazinylene-(CH2)2-, ##-CH2-piperazinylene-(CH2)3-, ##-CH2-piperazinylene-(CH2)4-, ##-CH2-piperazinylene-(CH2)5-, ##-CH2-piperazinylene-(CH2)6-, ##-CH2-piperazinylene-(CH2)7-, ##-CH2-piperazinylene-(CH2)8-, ##-(CH2)2-piperazinylene-(CH2)1-, ##-(CH2)2-piperazinylene-(CH2)2-, ##-(CH2)2-piperazinylene-(CH2)3-, ##-(CH2)2-piperazinylene-(CH2)4-, ##-(CH2)2-piperazinylene-(CH2)5-, ##-(CH2)2-piperazinylene-(CH2)6-, ##-(CH2)2-piperazinylene-(CH2)7-, ##-(CH2)2-piperazinylene-(CH2)8-, ##-(CH2)3-piperazinylene-CH2-, ##-(CH2)3-piperazinylene-(CH2)2-, ##-(CH2)3-piperazinylene-(CH2)3-, ##-(CH2)3-piperazinylene-(CH2)4-, ##-(CH2)3-piperazinylene-(CH2)5-, ##-(CH2)3-piperazinylene-(CH2)6-, ##-(CH2)3-piperazinylene-(CH2)7-, ##-(CH2)3-piperazinylene-(CH2)8-, ##-(CH2)4-piperazinylene-CH2-, ##-(CH2)4-piperazinylene-(CH2)2-, ##-(CH2)4-piperazinylene-(CH2)3-, ##-(CH2)4-piperazinylene-(CH2)4-, ##-(CH2)4-piperazinylene-(CH2)5-, ##-(CH2)4-piperazinylene-(CH2)6-, ##-(CH2)4-piperazinylene-(CH2)7-, ##-(CH2)4-piperazinylene-(CH2)8-, ##-(CH2)5-piperazinylene-(CH2)1-, ##-(CH2)5-piperazinylene-(CH2)2-, ##-(CH2)5-piperazinylene-(CH2)3-, ##-(CH2)5-piperazinylene-(CH2)4-, ##-(CH2)5-piperazinylene-(CH2)5-, ##-(CH2)5-piperazinylene-(CH2)6-, ##-(CH2)5-piperazinylene-(CH2)7-, ##-(CH2)5-piperazinylene-(CH2)8-, ##-(CH2)6-piperazinylene-(CH2)1-, ##-(CH2)6-piperazinylene-(CH2)2-, ##-(CH2)6-piperazinylene-(CH2)3-, ##-(CH2)6-piperazinylene-(CH2)4-, ##-(CH2)6-piperazinylene-(CH2)5-, ##-(CH2)6-piperazinylene-(CH2)6-, ##-(CH2)6-piperazinylene-(CH2)7-, ##-(CH2)6-piperazinylene-(CH2)8-, ##-(CH2)7-piperazinylene-(CH2)1-, ##-(CH2)7-piperazinylene-(CH2)2-, ##-(CH2)7-piperazinylene-(CH2)3-, ##-(CH2)7-piperazinylene-(CH2)4-, ##-(CH2)7-piperazinylene-(CH2)8-, ##-(CH2)8-piperazinylene-CH2-, ##-(CH2)8-piperazinylene-(CH2)2-, ##-(CH2)8-piperazinylene-(CH2)3-, ##-(CH2)8-piperazinylene-(CH2)4-, ##-(CH2)8-piperazinylene-(CH2)5-, ##-(CH2)8-piperazinylene-(CH2)6-, ##-(CH2)8-piperazinylene-(CH2)7-, ##-(CH2)8-piperazinylene-(CH2)8-, ##-CH2-propylene-CH2-, ##-CH2-propylene-(CH2)2-, ##-CH2-propylene-(CH2)3-, ##-CH2-propylene-(CH2)4-, ##-CH2-propylene-(CH2)5-, ##-CH2-propylene-(CH2)6-, ##-CH2-propylene-(CH2)7-, ##-CH2-propylene-(CH2)8-, ##-(CH2)2-propylene-(CH2)1-, ##-(CH2)2-propylene-(CH2)2-, ##-(CH2)2-propylene-(CH2)3-, ##-(CH2)2-propylene-(CH2)4-, ##-(CH2)2-propylene-(CH2)5-, ##-(CH2)2-propylene-(CH2)6-, ##-(CH2)2-propylene-(CH2)7-, ##-(CH2)2-propylene-(CH2)8-, ##-(CH2)3-propylene-CH2-, ##-(CH2)3-propylene-(CH2)2-, ##-(CH2)3-propylene-(CH2)3-, ##-(CH2)3-propylene-(CH2)4-, ##-(CH2)3-propylene-(CH2)5-, ##-(CH2)3-propylene-(CH2)6-, ##-(CH2)3-propylene-(CH2)7-, ##-(CH2)3-propylene-(CH2)8-, ##-(CH2)4-propylene-CH2-, ##-(CH2)4-propylene-(CH2)2-, ##-(CH2)4-propylene-(CH2)3-, ##-(CH2)4-propylene-(CH2)4-, ##-(CH2)4-propylene-(CH2)5-, ##-(CH2)4-propylene-(CH2)6-, ##-(CH2)4-propylene-(CH2)7-, ##-(CH2)4-propylene-(CH2)8-, ##-(CH2)5-propylene-(CH2)1-, ##-(CH2)5-propylene-(CH2)2-, ##-(CH2)5-propylene-(CH2)3-, ##-(CH2)5-propylene-(CH2)4-, ##-(CH2)5-propylene-(CH2)5-, ##-(CH2)5-propylene-(CH2)6-, ##-(CH2)5-propylene-(CH2)7-, ##-(CH2)5-propylene-(CH2)8-, ##-(CH2)6-propylene-(CH2)1-, ##-(CH2)6-propylene-(CH2)2-, ##-(CH2)6-propylene-(CH2)3-, ##-(CH2)6-propylene-(CH2)4-, ##-(CH2)6-propylene-(CH2)5-, ##-(CH2)6-propylene-(CH2)6-, ##-(CH2)6-propylene-(CH2)7-, ##-(CH2)6-propylene-(CH2)8-, ##-(CH2)7-propylene-(CH2)1-, ##-(CH2)7-propylene-(CH2)2-, ##-(CH2)7-propylene-(CH2)3-, ##-(CH2)7-propylene-(CH2)4-, ##-(CH2)7-propylene-(CH2)s-, ##-(CH2)8-propylene-CH2-, ##-(CH2)8-propylene-(CH2)2-, ##-(CH2)8-propylene-(CH2)3-, ##-(CH2)8-propylene-(CH2)4-, ##-(CH2)8-propylene-(CH2)5-, ##-(CH2)8-propylene-(CH2)6-, ##-(CH2)8-propylene-(CH2)7-, ##-(CH2)8-propylene-(CH2)8-, ##-CH2-diazacycloheptanylene-CH2-, ##-CH2-diazacycloheptanylene-(CH2)2-, ##-CH2-diazacycloheptanylene-(CH2)3-, ##-CH2-diazacycloheptanylene-(CH2)4-, ##-CH2-diazacycloheptanylene-(CH2)5-, ##-CH2-diazacycloheptanylene-(CH2)6-, ##-CH2-diazacycloheptanylene-(CH2)7-, ##-CH2-diazacycloheptanylene-(CH2)8-, ##-(CH2)2-diazacycloheptanylene-(CH2)1-, ##-(CH2)2-diazacycloheptanylene-(CH2)2-, ##-(CH2)2-diazacycloheptanylene-(CH2)3-, ##-(CH2)2-diazacycloheptanylene-(CH2)4-, ##-(CH2)2-diazacycloheptanylene-(CH2)5-, ##-(CH2)2-diazacycloheptanylene-(CH2)6-, ##-(CH2)2-diazacycloheptanylene-(CH2)7-, ##-(CH2)2-diazacycloheptanylene-(CH2)8-, ##-(CH2)3-diazacycloheptanylene-CH2-, ##-(CH2)3-diazacycloheptanylene-(CH2)2-, ##-(CH2)3-diazacycloheptanylene-(CH2)3-, ##-(CH2)3-diazacycloheptanylene-(CH2)4-, ##-(CH2)3-diazacycloheptanylene-(CH2)5-, ##-(CH2)3-diazacycloheptanylene-(CH2)6-, ##-(CH2)3-diazacycloheptanylene-(CH2)7-, ##-(CH2)3-diazacycloheptanylene-(CH2)8-, ##-(CH2)4-diazacycloheptanylene-CH2-, ##-(CH2)4-diazacycloheptanylene-(CH2)2-, ##-(CH2)4-diazacycloheptanylene-(CH2)3-, ##-(CH2)4-diazacycloheptanylene-(CH2)4-, ##-(CH2)4-diazacycloheptanylene-(CH2)5-, ##-(CH2)4-diazacycloheptanylene-(CH2)6-, ##-(CH2)4-diazacycloheptanylene-(CH2)7-, ##-(CH2)4-diazacycloheptanylene-(CH2)8-, ##-(CH2)5-diazacycloheptanylene-(CH2)1-, ##-(CH2)5-diazacycloheptanylene-(CH2)2-, ##-(CH2)5-diazacycloheptanylene-(CH2)3-, ##-(CH2)5-diazacycloheptanylene-(CH2)4-, ##-(CH2)5-diazacycloheptanylene-(CH2)5-, ##-(CH2)5-diazacycloheptanylene-(CH2)6-, ##-(CH2)5-diazacycloheptanylene-(CH2)7-, ##-(CH2)5-diazacycloheptanylene-(CH2)8-, ##-(CH2)6-diazacycloheptanylene-(CH2)1-, ##-(CH2)e-diazacycloheptanylene-(CH2)2-, ##-(CH2)6-diazacycloheptanylene-(CH2)3-, ##-(CH2)6-diazacycloheptanylene-(CH2)4-, ##-(CH2)6-diazacycloheptanylene-(CH2)5-, ##-(CH2)6-diazacycloheptanylene-(CH2)6-, ##-(CH2)6-diazacycloheptanylene-(CH2)7-, ##-(CH2)6-diazacycloheptanylene-(CH2)8-, ##-(CH2)7-diazacycloheptanylene-(CH2)1-, ##-(CH2)7-diazacycloheptanylene-(CH2)2-, ##-(CH2)7-diazacycloheptanylene-(CH2)3-, ##-(CH2)7-diazacycloheptanylene-(CH2)4-, ##-(CH2)7-diazacycloheptanylene-(CH2)8-, ##-(CH2)8-diazacycloheptanylene-CH2-, ##-(CH2)8-diazacycloheptanylene-(CH2)2-, ##-(CH2)8-diazacycloheptanylene-(CH2)3-, ##-(CH2)8-diazacycloheptanylene-(CH2)4-, ##-(CH2)8-diazacycloheptanylene-(CH2)5-, ##-(CH2)8-diazacycloheptanylene-(CH2)6-, ##-(CH2)s-diazacycloheptanylene-(CH2)7-, ##-(CH2)8-diazacycloheptanylene-(CH2)8-, ##-CH2-diazabicyclo[2.2.1]heptanylene-CH2-, ##-CH2-diazabicyclo[2.2.1]heptanylene-(CH2)2-, ##-CH2-diazabicyclo[2.2.1]heptanylene-(CH2)3-, ##-CH2-diazabicyclo[2.2.1]heptanylene-(CH2)4-, ##-CH2-diazabicyclo[2.2.1]heptanylene-(CH2)5-, ##-CH2-diazabicyclo[2.2.1]heptanylene-(CH2)6-, ##-CH2-diazabicyclo[2.2.1]heptanylene-(CH2)7-, ##-CH2-diazabicyclo[2.2.1]heptanylene-(CH2)8-, ##-(CH2)2-diazabicyclo[2.2.1]heptanylene-(CH2)1-, ##-(CH2)2-diazabicyclo[2.2.1]heptanylene-(CH2)2-, ##-(CH2)2-diazabicyclo[2.2.1]heptanylene-(CH2)3-, ##-(CH2)2-diazabicyclo[2.2.1]heptanylene-(CH2)4-, ##-(CH2)2-diazabicyclo[2.2.1]heptanylene-(CH2)5-, ##-(CH2)2-diazabicyclo[2.2.1]heptanylene-(CH2)6-, ##-(CH2)2-diazabicyclo[2.2.1]heptanylene-(CH2)7-, ##-(CH2)2-diazabicyclo[2.2.1]heptanylene-(CH2)8-, ##-(CH2)3-diazabicyclo[2.2.1]heptanylene-CH2-, ##-(CH2)3-diazabicyclo[2.2.l]heptanylene-(CH2)2-, ##-(CH2)3-diazabicyclo[2.2.1]heptanylene-(CH2)3-, ##-(CH2)3-diazabicyclo[2.2.1]heptanylene-(CH2)4-, ##-(CH2)3-diazabicyclo[2.2.1]heptanylene-(CH2)5-, ##-(CH2)3-diazabicyclo[2.2.1]heptanylene-(CH2)6-, ##-(CH2)3-diazabicyclo[2.2.1]heptanylene-(CH2)7-, ##-(CH2)3-diazabicyclo[2.2.1]heptanylene-(CH2)8-, ##-(CH2)4-diazabicyclo[2.2.1]heptanylene-CH2-, ##-(CH2)4-diazabicyclo[2.2.1]heptanylene-(CH2)2-, ##-(CH2)4-diazabicyclo[2.2.1]heptanylene-(CH2)3-, ##-(CH2)4-diazabicyclo[2.2.1]heptanylene-(CH2)4-, ##-(CH2)4-diazabicyclo[2.2.1]heptanylene-(CH2)5-, ##-(CH2)4-diazabicyclo[2.2.1]heptanylene-(CH2)6-, ##-(CH2)4-diazabicyclo[2.2.1]heptanylene-(CH2)7-, ##-(CH2)4-diazabicyclo[2.2.1]heptanylene-(CH2)8-, ##-(CH2)5-diazabicyclo[2.2.1]heptanylene-(CH2)1-, ##-(CH2)5-diazabicyclo[2.2.1]heptanylene-(CH2)2-, ##-(CH2)5-diazabicyclo[2.2.1]heptanylene-(CH2)3-, ##-(CH2)5-diazabicyclo[2.2.1]heptanylene-(CH2)4-, ##-(CH2)5-diazabicyclo[2.2.1]heptanylene-(CH2)5-, ##-(CH2)5-diazabicyclo[2.2.1]heptanylene-(CH2)6-, ##-(CH2)5-diazabicyclo[2.2.1]heptanylene-(CH2)7-, ##-(CH2)5-diazabicyclo[2.2.1]heptanylene-(CH2)8-, ##-(CH2)6-diazabicyclo[2.2.1]heptanylene-(CH2)1-, ##-(CH2)6-diazabicyclo[2.2.1]heptanylene-(CH2)2-, ##-(CH2)6-diazabicyclo[2.2.1]heptanylene-(CH2)3-, ##-(CH2)6-diazabicyclo[2.2.1]heptanylene-(CH2)4-, ##-(CH2)6-diazabicyclo[2.2.1]heptanylene-(CH2)5-, ##-(CH2)6-diazabicyclo[2.2.1]heptanylene-(CH2)6-, ##-(CH2)6-diazabicyclo[2.2.1]heptanylene-(CH2)7-, ##-(CH2)6-diazabicyclo[2.2.1]heptanylene-(CH2)8-, ##-(CH2)7-diazabicyclo[2.2.1]heptanylene-(CH2)1-, ##-(CH2)7-diazabicyclo[2.2.1]heptanylene-(CH2)2-, ##-(CH2)7-diazabicyclo[2.2.1]heptanylene-(CH2)3-, ##-(CH2)7-diazabicyclo[2.2.1]heptanylene-(CH2)4-, ##-(CH2)7-diazabicyclo[2.2.1]heptanylene-(CH2)8-, ##-(CH2)8-diazabicyclo[2.2.1]heptanylene-CH2-, ##-(CH2)8-diazabicyclo[2.2.1]heptanylene-(CH2)2-, ##-(CH2)8-diazabicyclo[2.2.1]heptanylene-(CH2)3-, ##-(CH2)8-diazabicyclo[2.2.1]heptanylene-(CH2)4-, ##-(CH2)8-diazabicyclo[2.2.1]heptanylene-(CH2)5-, ##-(CH2)8-diazabicyclo[2.2.1]heptanylene-(CH2)6-, ##-(CH2)8-diazabicyclo[2.2.1]heptanylene-(CH2)7-, ##-(CH2)8-diazabicyclo[2.2.1]heptanylene-(CH2)8-, ##-CH2-diazabicyclo[3.1.1]heptanylene-CH2-, ##-CH2-diazabicyclo[3.1.1]heptanylene-(CH2)2-, ##-CH2-diazabicyclo[3.1.1]heptanylene-(CH2)3-, ##-CH2-diazabicyclo[3.1.1]heptanylene-(CH2)4-, ##-CH2-diazabicyclo[3.1.1]heptanylene-(CH2)5-, ##-CH2-diazabicyclo[3.1.1]heptanylene-(CH2)6-, ##-CH2-diazabicyclo[3.1.1]heptanylene-(CH2)7-, ##-CH2-diazabicyclo[3.1.1]heptanylene-(CH2)8-, ##-(CH2)2-diazabicyclo[3.1.1]heptanylene-(CH2)1-, ##-(CH2)2-diazabicyclo[3.1.1]heptanylene-(CH2)2-, ##-(CH2)2-diazabicyclo[3.1.1]heptanylene-(CH2)3-, ##-(CH2)2-diazabicyclo[3.1.1]heptanylene-(CH2)4-, ##-(CH2)2-diazabicyclo[3.1.1]heptanylene-(CH2)5-, ##-(CH2)2-diazabicyclo[3.1.1]heptanylene-(CH2)6-, ##-(CH2)2-diazabicyclo[3.1.1]heptanylene-(CH2)7-, ##-(CH2)2-diazabicyclo[3.1.1]heptanylene-(CH2)8-, ##-(CH2)3-diazabicyclo[3.1.1]heptanylene-CH2-, ##-(CH2)3-diazabicyclo[3.1.1]heptanylene-(CH2)2-, ##-(CH2)3-diazabicyclo[3.1.1]heptanylene-(CH2)3-, ##-(CH2)3-diazabicyclo[3.1.1]heptanylene-(CH2)4-, ##-(CH2)3-diazabicyclo[3.1.1]heptanylene-(CH2)5-, ##-(CH2)3-diazabicyclo[3.1.1]heptanylene-(CH2)6-, ##-(CH2)3-diazabicyclo[3.1.1]heptanylene-(CH2)7-, ##-(CH2)3-diazabicyclo[3.1.1]heptanylene-(CH2)8-, ##-(CH2)4-diazabicyclo[3.1.1]heptanylene-CH2-, ##-(CH2)4-diazabicyclo[3.1.1]heptanylene-(CH2)2-, ##-(CH2)4-diazabicyclo[3.1.1]heptanylene-(CH2)3-, ##-(CH2)4-diazabicyclo[3.1.1]heptanylene-(CH2)4-, ##-(CH2)4-diazabicyclo[3.1.1]heptanylene-(CH2)5-, ##-(CH2)4-diazabicyclo[3.1.1]heptanylene-(CH2)6-, ##-(CH2)4-diazabicyclo[3.1.1]heptanylene-(CH2)7-, ##-(CH2)4-diazabicyclo[3.1.1]heptanylene-(CH2)8-, ##-(CH2)5-diazabicyclo[3.1.1]heptanylene-(CH2)1-, ##-(CH2)5-diazabicyclo[3.1.1]heptanylene-(CH2)2-, ##-(CH2)5-diazabicyclo[3.1.1]heptanylene-(CH2)3-, ##-(CH2)5-diazabicyclo[3.1.1]heptanylene-(CH2)4-, ##-(CH2)5-diazabicyclo[3.1.1]heptanylene-(CH2)5-, ##-(CH2)5-diazabicyclo[3.1.1]heptanylene-(CH2)6-, ##-(CH2)5-diazabicyclo[3.1.1]heptanylene-(CH2)7-, ##-(CH2)5-diazabicyclo[3.1.1]heptanylene-(CH2)8-, ##-(CH2)6-diazabicyclo[3.1.1]heptanylene-(CH2)1-, ##-(CH2)6-diazabicyclo[3.1.1]heptanylene-(CH2)2-, ##-(CH2)6-diazabicyclo[3.1.1]heptanylene-(CH2)3-, ##-(CH2)6-diazabicyclo[3.1.1]heptanylene-(CH2)4-, ##-(CH2)6-diazabicyclo[3.1.1]heptanylene-(CH2)5-, ##-(CH2)6-diazabicyclo[3.1.1]heptanylene-(CH2)6-, ##-(CH2)6-diazabicyclo[3.1.1]heptanylene-(CH2)7-, ##-(CH2)6-diazabicyclo[3.1.1]heptanylene-(CH2)8-, ##-(CH2)7-diazabicyclo[3.1.1]heptanylene-(CH2)1-, ##-(CH2)7-diazabicyclo[3.1.1]heptanylene-(CH2)2-, ##-(CH2)7-diazabicyclo[3.1.1]heptanylene-(CH2)3-, ##-(CH2)7-diazabicyclo[3.1.1]heptanylene-(CH2)4-, ##-(CH2)7-diazabicyclo[3.1.1]heptanylene-(CH2)8-, ##-(CH2)5-diazabicyclo[3.1.1]heptanylene-CH2-, ##-(CH2)5-diazabicyclo[3.1.1]heptanylene-(CH2)2-, ##-(CH2)5-diazabicyclo[3.1.1]heptanylene-(CH2)3-, ##-(CH2)8-diazabicyclo[3.1.1]heptanylene-(CH2)4-, ##-(CH2)8-diazabicyclo[3.1.1]heptanylene-(CH2)5-, ##-(CH2)5-diazabicyclo[3.1.1]heptanylene-(CH2)6-, ##-(CH2)8-diazabicyclo[3.1.1]heptanylene-(CH2)7-, ##-(CH2)8-diazabicyclo[3.1.1]heptanylene-(CH2)8-, ##-CH2-diazabicyclo[3.2.1]octylene-CH2-, ##-CH2-diazabicyclo[3.2.1]octylene-(CH2)2-, ##-CH2-diazabicyclo[3.2.1]octylene-(CH2)3-, ##-CH2-diazabicyclo[3.2.1]octylene-(CH2)4-, ##-CH2-diazabicyclo[3.2.1]octylene-(CH2)5-, ##-CH2-diazabicyclo[3.2.1]octylene-(CH2)6-, ##-CH2-diazabicyclo[3.2.1]octylene-(CH2)7-, ##-CH2-diazabicyclo[3.2.1]octylene-(CH2)5-, ##-(CH2)2-diazabicyclo[3.2.1]octylene-(CH2)1-, ##-(CH2)2-diazabicyclo[3.2.1]octylene-(CH2)2-, ##-(CH2)2-diazabicyclo[3.2.1]octylene-(CH2)3-, ##-(CH2)2-diazabicyclo[3.2.1]octylene-(CH2)4-, ##-(CH2)2-diazabicyclo[3.2.1]octylene-(CH2)5-, ##-(CH2)2-diazabicyclo[3.2.1]octylene-(CH2)6-, ##-(CH2)2-diazabicyclo[3.2.1]octylene-(CH2)7-, ##-(CH2)2-diazabicyclo[3.2.1]octylene-(CH2)8-, ##-(CH2)3-diazabicyclo[3.2.1]octylene-CH2-, ##-(CH2)3-diazabicyclo[3.2.1]octylene-(CH2)2-, ##-(CH2)3-diazabicyclo[3.2.1]octylene-(CH2)3-, ##-(CH2)3-diazabicyclo[3.2.1]octylene-(CH2)4-, ##-(CH2)3-diazabicyclo[3.2.1]octylene-(CH2)5-, ##-(CH2)3-diazabicyclo[3.2.1]octylene-(CH2)6-, ##-(CH2)3-diazabicyclo[3.2.1]octylene-(CH2)7-, ##-(CH2)3-diazabicyclo[3.2.1]octylene-(CH2)8-, ##-(CH2)4-diazabicyclo[3.2.1]octylene-CH2-, ##-(CH2)4-diazabicyclo[3.

2. 1]octylene-(CH2)2-, ##-(CH2)4-diazabicyclo[3.2.1]octylene-(CH2)3-, ##-(CH2)4-diazabicyclo[3.2.1]octylene-(CH2)4-, ##-(CH2)4-diazabicyclo[3.2.1]octylene-(CH2)5-, ##-(CH2)4-diazabicyclo[3.2.1]octylene-(CH2)6-, ##-(CH2)4-diazabicyclo[3.2.1]octylene-(CH2)7-, ##-(CH2)4-diazabicyclo[3.2.1]octylene-(CH2)8-, ##-(CH2)5-diazabicyclo[3.2.1]octylene-(CH2)1-, ##-(CH2)5-diazabicyclo[3.2.1]octylene-(CH2)2-, ##-(CH2)5-diazabicyclo[3.2.1]octylene-(CH2)3-, ##-(CH2)5-diazabicyclo[3.2.1]octylene-(CH2)4-, ##-(CH2)5-diazabicyclo[3.2.1]octylene-(CH2)5-, ##-(CH2)5-diazabicyclo[3.2.1]octylene-(CH2)6-, ##-(CH2)5-diazabicyclo[3.2.1]octylene-(CH2)7-, ##-(CH2)5-diazabicyclo[3.2.1]octylene-(CH2)8-, ##-(CH2)6-diazabicyclo[3.

2. 1]octylene-(CH2)1-, ##-(CH2)6-diazabicyclo[3.2.1]octylene-(CH2)2-, ##-(CH2)6-diazabicyclo[3.2.1]octylene-(CH2)3-, ##-(CH2)6-diazabicyclo[3.2.1]octylene-(CH2)4-, ##-(CH2)6-diazabicyclo[3.2.1]octylene-(CH2)5-, ##-(CH2)6-diazabicyclo[3.2.1]octylene-(CH2)6-, ##-(CH2)6-diazabicyclo[3.2.1]octylene-(CH2)7-, ##-(CH2)6-diazabicyclo[3.2.1]octylene-(CH2)8-, ##-(CH2)7-diazabicyclo[3.2.1]octylene-(CH2)1-, ##-(CH2)7-diazabicyclo[3.2.1]octylene-(CH2)2-, ##-(CH2)7-diazabicyclo[3.2.1]octylene-(CH2)3-, ##-(CH2)7-diazabicyclo[3.2.1]octylene-(CH2)4-, ##-(CH2)7-diazabicyclo[3.

2. 1]octylene-(CH2)5-, ##-(CH2)8-diazabicyclo[3.2.1]octylene-CH2-, ##-(CH2)8-diazabicyclo[3.2.1]octylene-(CH2)2-, ##-(CH2)8-diazabicyclo[3.2.1]octylene-(CH2)3-, ##-(CH2)8-diazabicyclo[3.2.1]octylene-(CH2)4-, ##-(CH2)8-diazabicyclo[3.2.1]octylene-(CH2)5-, ##-(CH2)8-diazabicyclo[3.2.1]octylene-(CH2)6-, ##-(CH2)8-diazabicyclo[3.2.1]octylene-(CH2)7-, ##-(CH2)8-diazabicyclo[3.2.1]octylene-(CH2)8-, ##-CH2-diazabicyclo[2.2.2]octylene-CH2-, ##-CH2-diazabicyclo[2.2.2]octylene-(CH2)2-, ##-CH2-diazabicyclo[2.2.2]octylene-(CH2)3-, ##-CH2-diazabicyclo[2.2.2]octylene-(CH2)4-, ##-CH2-diazabicyclo[2.2.2]octylene-(CH2)5-, ##-CH2-diazabicyclo[2.2.2]octylene-(CH2)6-, ##-CH2-diazabicyclo[2.2.2]octylene-(CH2)7-, ##-CH2-diazabicyclo[2.2.2]octylene-(CH2)8-, ##-(CH2)2-diazabicyclo[2.2.2]octylene-(CH2)1-, ##-(CH2)2-diazabicyclo[2.2.2]octylene-(CH2)2-, ##-(CH2)2-diazabicyclo[2.2.2]octylene-(CH2)3-, ##-(CH2)2-diazabicyclo[2.2.2]octylene-(CH2)4-, ##-(CH2)2-diazabicyclo[2.2.2]octylene-(CH2)5-, ##-(CH2)2-diazabicyclo[2.2.2]octylene-(CH2)6-, ##-(CH2)2-diazabicyclo[2.2.2]octylene-(CH2)7-, ##-(CH2)2-diazabicyclo[2.2.2]octylene-(CH2)8-, ##-(CH2)3-diazabicyclo[2.2.2]octylene-CH2-, ##-(CH2)3-diazabicyclo[2.2.2]octylene-(CH2)2-, ##-(CH2)3-diazabicyclo[2.2.2]octylene-(CH2)3-, ##-(CH2)3-diazabicyclo[2.2.2]octylene-(CH2)4-, ##-(CH2)3-diazabicyclo[2.2.2]octylene-(CH2)5-, ##-(CH2)3-diazabicyclo[2.2.2]octylene-(CH2)6-, ##-(CH2)3-diazabicyclo[2.2.2]octylene-(CH2)7-, ##-(CH2)3-diazabicyclo[2.2.2]octylene-(CH2)8-, ##-(CH2)4-diazabicyclo[2.2.2]octylene-CH2-, ##-(CH2)4-diazabicyclo[2.2.2]octylene-(CH2)2-, ##-(CH2)4-diazabicyclo[2.2.2]octylene-(CH2)3-, ##-(CH2)4-diazabicyclo[2.2.2]octylene-(CH2)4-, ##-(CH2)4-diazabicyclo[2.2.2]octylene-(CH2)5-, ##-(CH2)4-diazabicyclo[2.2.2]octylene-(CH2)6-, ##-(CH2)4-diazabicyclo[2.2.2]octylene-(CH2)7-, ##-(CH2)4-diazabicyclo[2.2.2]octylene-(CH2)8-, ##-(CH2)5-diazabicyclo[2.2.2]octylene-(CH2)1-, ##-(CH2)5-diazabicyclo[2.2.2]octylene-(CH2)2-, ##-(CH2)5-diazabicyclo[2.2.2]octylene-(CH2)3-, ##-(CH2)5-diazabicyclo[2.2.2]octylene-(CH2)4-, ##-(CH2)5-diazabicyclo[2.2.2]octylene-(CH2)5-, ##-(CH2)5-diazabicyclo[2.2.2]octylene-(CH2)6-, ##-(CH2)5-diazabicyclo[2.2.2]octylene-(CH2)7-, ##-(CH2)5-diazabicyclo[2.2.2]octylene-(CH2)8-, ##-(CH2)6-diazabicyclo[2.2.2]octylene-(CH2)i-, ##-(CH2)6-diazabicyclo[2.2.2]octylene-(CH2)2-, ##-(CH2)6-diazabicyclo[2.2.2]octylene-(CH2)3-, ##-(CH2)6-diazabicyclo[2.2.2]octylene-(CH2)4-, ##-(CH2)6-diazabicyclo[2.2.2]octylene-(CH2)5-, ##-(CH2)6-diazabicyclo[2.2.2]octylene-(CH2)6-, ##-(CH2)6-diazabicyclo[2.2.2]octylene-(CH2)7-, ##-(CH2)6-diazabicyclo[2.2.2]octylene-(CH2)8-, ##-(CH2)7-diazabicyclo[2.2.2]octylene-(CH2)1-, ##-(CH2)7-diazabicyclo[2.2.2]octylene-(CH2)2-, ##-(CH2)7-diazabicyclo[2.2.2]octylene-(CH2)3-, ##-(CH2)7-diazabicyclo[2.2.2]octylene-(CH2)4-, ##-(CH2)7-diazabicyclo[2.2.2]octylene-(CH2)8-, ##-(CH2)8-diazabicyclo[2.2.2]octylene-CH2-, ##-(CH2)8-diazabicyclo[2.2.2]octylene-(CH2)2-, ##-(CH2)s-diazabicyclo[2.2.2]octylene-(CH2)3-, ##-(CH2)8-diazabicyclo[2.2.2]octylene-(CH2)4-, ##-(CH2)8-diazabicyclo[2.2.2]octylene-(CH2)5-, ##-(CH2)8-diazabicyclo[2.2.2]octylene-(CH2)6-, ##-(CH2)8-diazabicyclo[2.2.2]octylene-(CH2)7-, or ##-(CH2)8-diazabicyclo[2.2.2]octylene-(CH2)8-; wherein the propylene, the piperidinylene, the piperazinylene, the diazacycloheptanylene, the diazabicyclo[2.2.1]heptanylene, the diazabicyclo[3.1.1]heptanylene, the diazabicyclo[3.2.1]octylene, the diazabicyclo[2.2.2]octylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-4 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH- or any combination thereof; each Rg10 independently represents H or C1-3 alkyl; and symbol ## indicates the point of attachment to X1; preferably, wherein L1 represents the following group: wherein symbol ## indicates the point of attachment to X1.

29. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in any one of claims 4-6 and 8, wherein L1 represents the structure of the following formula: ##-C1-30 alkylene-, wherein a hydrogen atom of one or more CH2 groups of the C1-30 alkylene is optionally replaced with a substituent selected from the group consisting of: D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, C1-6 alkoxy or any combination thereof, and symbol ## indicates the point of attachment to X1; preferably, wherein L1 represents the following group: ##-CH2-, ##-(CH2)2-, ##-(CH2)3-, ##-(CH2)4-, ##-(CH2)5-, ##-(CH2)2-CF2-(CH2)2-, ##-(CH2)6-, ##-(CH2)7-, ##-(CH2)8-, ##-(CH2)9-, ##-(CH2)10-, ##-(CH2)11-, ##-(CH2)12-, ##-(CH2)13-, ##-(CH2)14-, ##-(CH2)15-, ##-(CH2)16-, ##-(CH2)17-, ##-(CH2)18-, ##-(CH2)19-, ##-(CH2)20-, ##-(CH2)21-, ##-(CH2)22-, ##-(CH2)25-, or ##-(CH2)30-; wherein the hydrogen atom of one or more CH2 groups of the group is optionally replaced with a substituent selected from the group consisting of: D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, C1-6 alkoxy or any combination thereof, and symbol ## indicates the point of attachment to X1.

30. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 7, wherein L1 represents the structure of the following formula: ##-C4-30 alkylene-, wherein a hydrogen atom of one or more CH2 groups of the C4-30 alkylene is optionally replaced with a substituent selected from the group consisting of: D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, C1-6 alkoxy or any combination thereof, and symbol ## indicates the point of attachment to X1; preferably, wherein L1 represents the following group: ##-(CH2)4-, ##-(CH2)5-, ##-(CH2)2-CF2-(CH2)2-, ##-(CH2)6-, ##-(CH2)7-, ##-(CH2)8-, ##-(CH2)9-, ##-(CH2)10-, ##-(CH2)11-, ##-(CH2)12-, ##-(CH2)13-, ##-(CH2)14-, ##-(CH2)15-, ##-(CH2)16-, ##-(CH2)17-, ##-(CH2)18-, ##-(CH2)19-, ##-(CH2)20-, ##-(CH2)21-, ##-(CH2)22-, ##-(CH2)25-, or ##-(CH2)30-; wherein the hydrogen atom of one or more CH2 groups of the group is optionally replaced with a substituent selected from the group consisting of: D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, C1-6 alkoxy or any combination thereof, and symbol ## indicates the point of attachment to X1.

31. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in any one of claims 4-10, wherein Rb represents the following group: CH3, CF3, CD3, CH2CH3, -(CH2)2-CH3, -(CH2)3-CH3, -(CH2)4-CH3, -(CH2)5-CH3, -(CH2)6-CH3,-(CH2)7-CH3, -(CH2)8-CH3, -(CH2)9-CH3, -(CHZ)lo-CH3, -(CH2)11-CH3, -(CH2)12-CH3, -(CH2)13-CH3,-(CH2)14-CH3, -(CH2)15-CH3, -(CH2)16-CH3, -(CH2)17-CH3, -(CHZ)ls-CH3, -(CH2)19-CH3, -(CH2)20-CH3, -(CH2)21-CH3, -(CH2)22-CH3, -(CH2)23-CH3, -(CH2)24-CH3, -(CH2)25-CH3, -(CH2)26-CH3, -(CH2)27-CH3, -(CH2)28-CH3, or -(CH2)29-CH3.

32. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 1, wherein L2 or L3 each independently represent the structure of the following formula: -C2-30 alkylene-, wherein a hydrogen atom of one or more CH2 groups of the C2-30 alkylene is optionally replaced with a substituent selected from the group consisting of: D, C1-4 alkyl, halogen, C3-6cycloalkyl or any combination thereof; or preferably, wherein L2 or L3 each independently represent the following group: -CH2-, -(CH2)2-, -(CH2)3-, -(CH2)4-, -(CH2)5-, -(CH2)2-CF2-(CH2)2-, -(CH2)6-, -(CH2)7-, -(CH2)8-,-(CH2)9-, -(CH2)10-, -(CH2)11-, -(CH2)12-, -(CH2)13-, -(CH2)14-, -(CH2)15-, -(CH2)16-, -(CH2)17-,-(CH2)18-, -(CH2)19-, -(CH2)20-, -(CH2)21-, -(CH2)22-, -(CH2)25-, or -(CH2)30-; wherein the hydrogen atom of one or more CH2 groups of the group is optionally replaced with a substituent selected from the group consisting of: D, C1-4 alkyl, halogen, C3-6cycloalkyl or any combination thereof.

33. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 1, wherein (i) L2 represents the structure of the following formula:         -(C(Ra9)(Ra10))m1-(R12(C(Ra11)(Ra12))m2)p1-;         -(C(Ra9)(Ra10))m1-(R12(C(Ra11)(Ra12))m2)p1-R12(R12(C(Ra13)(Ra14))m3)p2-;         _(C(Ra9)(Ra10))m1-(R12(C(Ra11)(Ra12))m2)p1-(R12(C(Ra13)(Ra14))m3)p2-(R12(C(Ra15)(Ra16))m4)p3-;         -(C(Ra9)(Ra10))m1-(R13(C(Ra11)(Ra12))m2)p1-;         -(C(Ra9)(Ra10))m1-(R13(C(Ra11)(Ra12))m2)p1-(R13(C(Ra13)(Ra14))m3)p2-;         -(C(Ra9)(Ra10))m1-(R13(C(Ra11)(Ra12))m2)p1-(R13(C(Ra13)(Ra14))m3)p2-(R13(C(Ra15)(Ra16))m4)p3-;         -(C(Ra9)(Ra10))m1-(R12-R13-(C(Ra11)(Ra12))m2)p1-;         -(C(Ra9)(Ra10))m1-(R12(C(Ra11)(Ra12))m2)p1-(R13(C(Ra13)(Ra14))m3)p2-;         -(C(Ra9)(Ra10))m1-(R13-R12-(C(Ra11)(Ra12))m2)p1-; or         -(C(Ra9)(Ra10))m1-(R13(C(Ra11)(Ra12))m2)p1-(R12(C(Ra13)(Ra14))m3)p2-; wherein each R12 is independently selected from the group consisting of O, S, N(R14), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, wherein each R14 independently represents H or C1-3 alkyl; and each group R13 is independently selected from the group consisting of optionally substituted C3-15cycloalkylene, optionally substituted 4- to 15-membered heterocyclylene, optionally substituted C6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C2-6 alkenylene, C2-6 alkynylene or any combination thereof, wherein the C3-15cycloalkylene, the C6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-4 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH- or any combination thereof; Ra9, Ra10, Ra11, Ra12, Ra13, Ra14, Ra15 and Ra16 each independently represent H, deuterium, halogen, C1-4 alkyl, C3-6cycloalkyl or any combination thereof; and m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15; and / or (ii) L3 represents the structure of the following formula:         -(C(Ra9)(Ra10))m1-(R16(C(Ra11)(Ra12))m2)p1-;         -(C(Ra9)(Ra10))m1-(R16(C(Ra11)(Ra12))m2)p1-(R16(C(Ra13)(Ra14))m3)p2-;         -(C(Ra9)(Ra10))m1-(R16(C(Ra11)(Ra12))m2)p1-(R16(C(Ra13)(Ra14))m3)p2-(R16(C(Ra15)(Ra16))m4)p3-;         -(C(Ra9)(Ra10))m1-(R17(C(Ra11)(Ra12))m2)p1-;         -(C(Ra9)(Ra10))m1-(R17(C(Ra11)(Ra12))m2)p1-(R17(C(Ra13)(Ra14))m3)p2-;         -(C(Ra9)(Ra10))m1-(R17(C(Ra11)(Ra12))m2)p1-(R17(C(Ra13)(Ra14))m3)p2-(R17(C(Ra15)(Ra16))m4)p3-;         -(C(Ra9)(Ra10))m1-(R16-R17-(C(Ra11)(Ra12))m2)p1-;         -(C(Ra9)(Ra10))m1-(R16(C(Ra11)(Ra12))m2)p1-(R17(C(Ra13)(Ra14))m3)p2-;         -(C(Ra9)(Ra10))m1-(R17-R16-(C(Ra11)(Ra12))m2)p1-; or         -(C(Ra9)(Ra10))m1-(R17(C(Ra11)(Ra12))m2)p1-(R16(C(Ra13)(Ra14))m3)p2-; wherein each group R16 is independently selected from the group consisting of O, S, N(R18), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, wherein each R18 independently represents H or C1-3 alkyl; and each group R17 is independently selected from the group consisting of optionally substituted C3-15cycloalkylene, optionally substituted 4- to 15-membered heterocyclylene, optionally substituted C6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C2-6 alkenylene, C2-6 alkynylene or any combination thereof, wherein the C3-15cycloalkylene, the C6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-4 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH- or any combination thereof; Ra9, Ra10, Ra11, Ra12, Ra13, Ra14, Ra15 and Ra16 each independently represent H, deuterium, halogen, C1-4 alkyl, C3-6cycloalkyl or any combination thereof; and m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15; or preferably, wherein L2 or L3 each independently represent the structure of the following formula:         -(C(Ra9)(Ra10)m1-(O(C(Ra11)(Ra12))m2)p1-;         -(C(Ra9)(Ra10))m1-(O(C(Ra11)(Ra12))m2)p1-(O(C(Ra13)(Ra14))m3)p2-;         --(C(Ra9)(Ra10))m1-(O(C(Ra11)(Ra12))m2)p1-(O(C(Ra13)(Ra14))m3)p2-(O(C(Ra15)(Ra16))m4)p3-;         -(C(Ra9)(Ra10))m1-(N(Rg11)(C(Ra11)(Ra12))m2)p1-;         -(C(Ra9)(Ra10))m1-(N(Rg11)(C(Ra11)(Ra12))m2)p1-(N(Rg11)(C(Ra13)(Ra14))m3)p2-;         -(C(Ra9)(Ra10))m1-(N(Rg11)(C(Ra11)(Ra12))m2)p1-(N(Rg11)(C(Ra13)(Ra14))m3)p2-(N(Rg11)(C(Ra15)(Ra16))m4)p3-;         -(C(Ra9)(Ra10))m1-(C(O)NH-(C(Ra11)(Ra12))m2)p1-;         -(C(Ra9)(Ra10))m1-(C(O)NH-(C(Ra11)(Ra12))m2)p1-(C(O)NH-(C(Ra13)(Ra14))m3)p2-;         -(C(Ra9)(Ra10))m1-(C(O)NH-(C(Ra11)(Ra12))m2)p1-(C(O)NH-(C(Ra13)(Ra14))m3)p2-(C(O)NH-(C(Ra15)(Ra16))m4)p3-;         -(C(Ra9)(Ra10))m1-(C(O)NH-(C(Ra11)(Ra12))m2)p1-(O-(C(Ra13)(Ra14))m3)p2-;         -(C(Ra9)(Ra10))m1-C(O)NH-(C(Ra11)(Ra12))m2-(O(C(Ra13)(Ra14))m3)p1-;         -(C(Ra9)(Ra10))m1-(NHC(O)-(C(Ra11)(Ra12))m2)p1-;         -(C(Ra9)(Ra10))m1-(NHC(O)-(C(Ra11)(Ra12))m2)p1-(O-(C(Ra13)(Ra14))m3)p2-;         -(C(Ra9)(Ra10))m1-(NHC(O)-(C(Ra11)(Ra12))m2)p1-(O-(C(Ra13)(Ra14))m3)p2-(O-C(Ra15)(Ra16))m4)p3-;         -(C(Ra9)(Ra10))m1-NHC(O)-(C(Ra11)(Ra12))m2-(O(C(Ra13)(Ra14))m3)p1-;         -(C(Ra9)(Ra10))m1-NHC(O)NH-(C(Ra11)(Ra12))m2-;         -(C(Ra9)(Ra10))m1-(NHC(O)-(C(Ra11)(Ra12))m2-;         -(C(Ra9)(Ra10))m1-(NHC(O)-(C(Ra11)(Ra12))m2-;         -(C(Ra9)(Ra10))m1-S-(C(Ra11)(Ra12))m2-;         -(C(Ra9)(Ra10))m1-(C6-10 arylene-(C(Ra11)(Ra12))m2)p1-;         -(C(Ra9)(Ra10))m1-(C6-10 arylene-(C(Ra11)(Ra12))m2)p1-C6-10 arylene-(C(Ra13)(Ra14))m3-;         -(C(Ra9)(Ra10))m1-(4- to 15-membered heterocyclylene-(C(Ra11)(Ra12))m2)p1-;         -(C(Ra9)(Ra10))m1-(4- to 15-membered heterocyclylene-(C(Ra11)(Ra12))m2)p1-(4- to 15-membered heterocyclylene-(C(Ra13)(Ra14))m3)p2-;         -(C(Ra9)(Ra10))m1-(5- to 15-membered heteroarylene-(C(Ra11)(Ra12))m2)p1-;         -(C(Ra9)(Ra10))m1-(5- to 15-membered heteroarylene-(C(Ra11)(Ra12))m2)p1-(5- to 15-membered heteroarylene-(C(Ra13)(Ra14))m3)p2-;         -(C(Ra9)(Ra10))m1-(C3-15cycloalkylene-(C(Ra11)(Ra12))m2)p1-; or         -(C(Ra9)(Ra10))m1-(C3-15cycloalkylene-(C(Ra11)(Ra12))m2)p1-(C3-15cycloalkylene-(C(Ra13)(Ra14))m3)p2-; wherein each Rg11 independently represents H or C1-3 alkyl; the C3-15cycloalkylene, the C6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-4 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH- or any combination thereof; Ra9, Ra10, Ra11, Ra12, Ra13, Ra14, Ra15 and Ra16 each independently represent H, deuterium, halogen, C1-4 alkyl, C3-6cycloalkyl or any combination thereof; and m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15; or more preferably, wherein L2 or L3 each independently represent the structure of the following formula: -CH2-O-CH2-, -CH2-O-(CH2)2-, -(CH2)1-O-(CH2)3-, -(CH2)1-O-(CH2)4-, -(CH2)1-O-(CH2)5-, - (CH2)1-O-(CH2)6-, -(CH2)1-O-(CH2)7-, -(CH2)1-O-(CH2)8-, -(CH2)1-O-(CH2)9-, -(CH2)1-O-(CH2)10-, - (CH2)2-O-(CH2)1-, -(CH2)2-O-(CH2)2-, -(CH2)2-O-(CH2)3-, -(CH2)2-O-(CH2)4-, -(CH2)2-O-(CH2)5-, - (CH2)2-O-(CH2)6-, -(CH2)2-O-(CH2)7-, -(CH2)2-O-(CH2)8-, -(CH2)2-O-(CH2)9-, -(CH2)2-O-(CH2)10-, - (CH2)2-O-(CH2)11-, -(CH2)2-O-(CH2)12-, -(CH2)3-O-(CH2)1-, -(CH2)3-O-(CH2)2-, -(CH2)3-O-(CH2)3-, - (CH2)3-O-(CH2)4-, -(CH2)3-O-(CH2)5-, -(CH2)3-O-(CH2)6-, -(CH2)3-O-(CH2)7-, -(CH2)4-O-(CH2)1-, - (CH2)4-O-(CH2)2-, -(CH2)4-O-(CH2)3-, -(CH2)4-O-(CH2)4-, -(CH2)4-O-(CH2)5-, -(CH2)4-O-(CH2)6-, - (CH2)5-O-(CH2)1-, -(CH2)5-O-(CH2)2-, -(CH2)5-O-(CH2)3-, -(CH2)5-O-(CH2)4-, -(CH2)5-O-(CH2)5-, - (CH2)6-O-(CH2)1-, -(CH2)6-O-(CH2)2-, -(CH2)6-O-(CH2)3-, -(CH2)6-O-(CH2)4-, -(CH2)7-O-(CH2)1-, - (CH2)7-O-(CH2)2-, -(CH2)7-O-(CH2)3-, -(CH2)8-O-(CH2)1-, -(CH2)8-O-(CH2)2-, -CH(CH3)-O-(CH2)1-,-CH(CH3)-O-(CH2)2-, -CH(CH3)-O-(CH2)3-, -CH(CH3)-O-(CH2)4-, -CH(CH3)-O-(CH2)5-, -CH(CH3)-O-(CH2)6-, -CH(CH3)-O-(CH2)7-, -CH(CH3)-O-(CH2)8-, -CH(CH3)-O-(CH2)9-, -CH(CH3)-O-(CH2)10-, -CH2-(O(CH2)2)2-, -CH2-(O(CH2)2)3-, -CH2-(O(CH2)2)4-, -CH2-(O(CH2)2)5-, -CH2-(O(CH2)2)6-, -CH2-(O(CH2)2)7-, -CH2-(O(CH2)2)8-, -CH2-(O(CH2)2)9-, -CH2-(O(CH2)2)10-, -CH2-(O(CH2)2)1-OCH2-, - CH2-(O(CH2)2)2-OCH2-, -CH2-(O(CH2)2)3-OCH2-, -CH2-(O(CH2)2)4-OCH2-, -CH2-(O(CH2)2)5-OCH2-, -CH2-(O(CH2)2)6-OCH2-, -CH2-(O(CH2)2)7-OCH2-, -CH2-(O(CH2)2)8-OCH2-, -CH2-(O(CH2)2)9-OCH2-, -CH2-(O(CH2)2)10-OCH2-, -(CH2)2-(O(CH2)2)2-, -(CH2)2-(O(CH2)2)3-, -(CH2)2-(O(CH2)2)4-, - (CH2)2-(O(CH2)2)5-, -(CH2)2-(O(CH2)2)6-, -(CH2)2-(O(CH2)2)7-, -(CH2)2-(O(CH2)2)8-, -(CH2)2-(O(CH2)2)9-, -(CH2)2-(O(CH2)2)10-, -(CH2)3-(O(CH2)2)2-, -(CH2)3-(O(CH2)2)3-, -(CH2)3-(O(CH2)2)4-, - (CH2)3-(O(CH2)2)5-, -(CH2)3-(O(CH2)2)6-, -(CH2)3-(O(CH2)2)7-, -(CH2)3-(O(CH2)2)8-, -(CH2)3-(O(CH2)2)9-, -(CH2)3-(O(CH2)2)10-, -(CH2)4-(O(CH2)2)2-, -(CH2)4-(O(CH2)2)3-, -(CH2)4-(O(CH2)2)4-, - (CH2)4-(O(CH2)2)5-, -(CH2)4-(O(CH2)2)6-, -(CH2)4-(O(CH2)2)7-, -(CH2)4-(O(CH2)2)8-, -(CH2)4-(O(CH2)2)9-, -(CH2)4-(O(CH2)2)10-, -CH2-(O(CH2)3)2-, -CH2-(O(CH2)3)3-, -CH2-(O(CH2)3)4-, -CH2-(O(CH2)3)5-, -CH2-(O(CH2)3)6-, -CH2-(O(CH2)3)7-, -CH2-(O(CH2)3)8-, -CH2-(O(CH2)3)9-, -CH2-(O(CH2)3)10-, -(CH2)2-(O(CH2)3)2-, -(CH2)2-(O(CH2)3)3-, -(CH2)2-(O(CH2)3)4-, -(CH2)2-(O(CH2)3)5-,-(CH2)2-(O(CH2)3)6-, -(CH2)2-(O(CH2)3)7-, -(CH2)2-(O(CH2)3)8-, -(CH2)2-(O(CH2)3)9-, -(CH2)2-(O(CH2)3)10-, -(CH2)3-(O(CH2)3)2-, -(CH2)3-(O(CH2)3)3-, -(CH2)3-(O(CH2)3)4-, -(CH2)3-(O(CH2)3)5-, - (CH2)3-(O(CH2)3)6-, -(CH2)3-(O(CH2)3)7-, -(CH2)3-(O(CH2)3)8-, -(CH2)3-(O(CH2)3)9-, -(CH2)3-(O(CH2)3)10-, -CH2-O-(CH2)2-O-(CH2)3-, -CH2-(O(CH2)2)2-(O(CH2)3)2-, -CH2-(O(CH2)2)3-(O(CH2)3)3-, -CH2-(O(CH2)2)4-(O(CH2)3)4-, -CH2-(O(CH2)2)5-(O(CH2)3)5-, -CH2-(O(CH2)2)6-(O(CH2)3)6-, -(CH2)2-O-(CH2)2-O-(CH2)3-, -(CH2)2-(O(CH2)2)2-(O(CH2)3)2-, -(CH2)2-(O(CH2)2)3-(O(CH2)3)3-, -(CH2)2-(O(CH2)2)4-(O(CH2)3)4-, -(CH2)2-(O(CH2)2)5-(O(CH2)3)5-, -(CH2)2-(O(CH2)2)6-(O(CH2)3)6-, -(CH2)3-O-(CH2)2-O-(CH2)3-, -(CH2)3-(O(CH2)2)2-(O(CH2)3)2-, -(CH2)3-(O(CH2)2)3-(O(CH2)3)3-, -(CH2)3-(O(CH2)2)4-(O(CH2)3)4-, -(CH2)3-(O(CH2)2)5-(O(CH2)3)5-, -(CH2)3-(O(CH2)2)6-(O(CH2)3)6-, -CH2-O-(CH2)3-O-(CH2)2-, -CH2-(O(CH2)3)2-(O(CH2)2)2-, -CH2-(O(CH2)3)3-(O(CH2)2)3-, -CH2-(O(CH2)3)4-(O(CH2)2)4-, -CH2-(O(CH2)3)5-(O(CH2)2)5-, -CH2-(O(CH2)3)6-(O(CH2)2)6-, -(CH2)2-O-(CH2)3-O-(CH2)2-, -(CH2)2-(O(CH2)3)2-(O(CH2)2)2-, -(CH2)2-(O(CH2)3)3-(O(CH2)2)3-, -(CH2)2-(O(CH2)3)4-(O(CH2)2)4-, -(CH2)2-(O(CH2)3)5-(O(CH2)2)5-, -(CH2)2-(O(CH2)3)6-(O(CH2)2)6-, -(CH2)3-O-(CH2)3-O-(CH2)2-, -(CH2)3-(O(CH2)3)2-(O(CH2)2)2-, -(CH2)3-(O(CH2)3)3-(O(CH2)2)3-, -(CH2)3-(O(CH2)3)4-(O(CH2)2)4-, -(CH2)3-(O(CH2)3)5-(O(CH2)2)5-, -(CH2)3-(O(CH2)3)6-(O(CH2)2)6-, -CH2-O-(CH2)2-O-CH2-, -(CH2)2-O-(CH2)2-O-CH2-, -(CH2)2-(O(CH2)2)2-O-(CH2)3-, -(CH2)2-(O(CH2)2)3-O-(CH2)3-, - (CH2)2-(O(CH2)2)4-O-(CH2)3-, -(CH2)5-(O(CH2)2)2-O-(CH2)5-, -(CH2)5-(O(CH2)2)2-O-(CH2)6-, -CH2-C(O)-CH2-, -CH2-C(O)-(CH2)2-, -(CH2)1-C(O)-(CH2)3-, -(CH2)1-C(O)-(CH2)4-, -(CH2)1-C(O)-(CH2)5-, -(CH2)1-C(O)-(CH2)6-, -(CH2)1-C(O)-(CH2)7-, -(CH2)1-C(O)-(CH2)8-, -(CH2)1-C(O)-(CH2)9-, -(CH2)1-C(O)-(CH2)10-, -(CH2)2-C(O)-(CH2)1-, -(CH2)2-C(O)-(CH2)2-, -(CH2)2-C(O)-(CH2)3-, -(CH2)2-C(O)-(CH2)4-, -(CH2)2-C(O)-(CH2)5-, -(CH2)2-C(O)-(CH2)6-, -(CH2)2-C(O)-(CH2)7-, -(CH2)2-C(O)-(CH2)8-, - (CH2)2-C(O)-(CH2)9-, -(CH2)2-C(O)-(CH2)10-, -(CH2)2-C(O)-(CH2)11-, -(CH2)2-C(O)-(CH2)12-, - (CH2)3-C(O)-(CH2)1-, -(CH2)3-C(O)-(CH2)2-, -(CH2)3-C(O)-(CH2)3-, -(CH2)3-C(O)-(CH2)4-, -(CH2)3-C(O)-(CH2)5-, -(CH2)3-C(O)-(CH2)6-, -(CH2)3-C(O)-(CH2)7-, -(CH2)4-C(O)-(CH2)1-, -(CH2)4-C(O)-(CH2)2-, -(CH2)4-C(O)-(CH2)3-, -(CH2)4-C(O)-(CH2)4-, -(CH2)4-C(O)-(CH2)5-, -(CH2)4-C(O)-(CH2)6-, - (CH2)5-C(O)-(CH2)1-, -(CH2)5-C(O)-(CH2)2-, -(CH2)5-C(O)-(CH2)3-, -(CH2)5-C(O)-(CH2)4-, -(CH2)5-C(O)-(CH2)5-, -(CH2)6-C(O)-(CH2)1-, -(CH2)6-C(O)-(CH2)2-, -(CH2)6-C(O)-(CH2)3-, -(CH2)6-C(O)-(CH2)4-, -(CH2)7-C(O)-(CH2)1-, -(CH2)7-C(O)-(CH2)2-, -(CH2)7-C(O)-(CH2)3-, -(CH2)8-C(O)-(CH2)1-, - (CH2)8-C(O)-(CH2)2-, -CH2-S-CH2-, -CH2-S-(CH2)2-, -(CH2)1-S-(CH2)3-, -(CH2)1-S-(CH2)4-, -(CH2)1-S-(CH2)5-, -(CH2)1-S-(CH2)6-, -(CH2)1-S-(CH2)7-, -(CH2)1-S-(CH2)8-, -(CH2)1-S-(CH2)9-, -(CH2)1-S-(CH2)10-, -(CH2)2-S-(CH2)1-, -(CH2)2-S-(CH2)2-, -(CH2)2-S-(CH2)3-, -(CH2)2-S-(CH2)4-, -(CH2)2-S-(CH2)5-, -(CH2)2-S-(CH2)6-, -(CH2)2-S-(CH2)7-, -(CH2)2-S-(CH2)8-, -(CH2)2-S-(CH2)9-, -(CH2)2-S-(CH2)10-, -(CH2)2-S-(CH2)11-, -(CH2)2-S-(CH2)12-, -(CH2)3-S-(CH2)1-, -(CH2)3-S-(CH2)2-, -(CH2)3-S-(CH2)3-, -(CH2)3-S-(CH2)4-, -(CH2)3-S-(CH2)5-, -(CH2)3-S-(CH2)6-, -(CH2)3-S-(CH2)7-, -(CH2)4-S-(CH2)1-, -(CH2)4-S-(CH2)2-, -(CH2)4-S-(CH2)3-, -(CH2)4-S-(CH2)4-, -(CH2)4-S-(CH2)5-, -(CH2)4-S-(CH2)6-, -(CH2)5-S-(CH2)1-, -(CH2)5-S-(CH2)2-, -(CH2)5-S-(CH2)3-, -(CH2)5-S-(CH2)4-, -(CH2)5-S-(CH2)5-, -(CH2)6-S-(CH2)1-, -(CH2)6-S-(CH2)2-, -(CH2)6-S-(CH2)3-, -(CH2)6-S-(CH2)4-, -(CH2)7-S-(CH2)1-, -(CH2)7-S-(CH2)2-, -(CH2)7-S-(CH2)3-, -(CH2)8-S-(CH2)1-, -(CH2)8-S-(CH2)2-, -CH2-C(S)-CH2-, -CH2-C(S)-(CH2)2-, -(CH2)1-C(S)-(CH2)3-, -(CH2)1-C(S)-(CH2)4-, -(CH2)1-C(S)-(CH2)5-, - (CH2)1-C(S)-(CH2)6-, -(CH2)1-C(S)-(CH2)7-, -(CH2)1-C(S)-(CH2)8-, -(CH2)1-C(S)-(CH2)9-, -(CH2)1-C(S)-(CH2)10-, -(CH2)2-C(S)-(CH2)1-, -(CH2)2-C(S)-(CH2)2-, -(CH2)2-C(S)-(CH2)3-, -(CH2)2-C(S)-(CH2)4-, -(CH2)2-C(S)-(CH2)5-, -(CH2)2-C(S)-(CH2)6-, -(CH2)2-C(S)-(CH2)7-, -(CH2)2-C(S)-(CH2)8-, - (CH2)2-C(S)-(CH2)9-, -(CH2)2-C(S)-(CH2)10-, -(CH2)2-C(S)-(CH2)11-, -(CH2)2-C(S)-(CH2)12-, -(CH2)3-C(S)-(CH2)1-, -(CH2)3-C(S)-(CH2)2-, -(CH2)3-C(S)-(CH2)3-, -(CH2)3-C(S)-(CH2)4-, -(CH2)3-C(S)-(CH2)5-, -(CH2)3-C(S)-(CH2)6-, -(CH2)3-C(S)-(CH2)7-, -(CH2)4-C(S)-(CH2)1-, -(CH2)4-C(S)-(CH2)2-,-(CH2)4-C(S)-(CH2)3-, -(CH2)4-C(S)-(CH2)4-, -(CH2)4-C(S)-(CH2)5-, -(CH2)4-C(S)-(CH2)6-, -(CH2)5-C(S)-(CH2)1-, -(CH2)5-C(S)-(CH2)2-, -(CH2)5-C(S)-(CH2)3-, -(CH2)5-C(S)-(CH2)4-, -(CH2)5-C(S)-(CH2)5-, -(CH2)6-C(S)-(CH2)1-, -(CH2)6-C(S)-(CH2)2-, -(CH2)6-C(S)-(CH2)3-, -(CH2)6-C(S)-(CH2)4-, - (CH2)7-C(S)-(CH2)1-, -(CH2)7-C(S)-(CH2)2-, -(CH2)7-C(S)-(CH2)3-, -(CH2)8-C(S)-(CH2)1-, -(CH2)8-C(S)-(CH2)2-, -CH2-C(O)O-CH2-, -CH2-C(O)O-(CH2)2-, -(CH2)1-C(O)O-(CH2)3-, -(CH2)1-C(O)O-(CH2)4-, -(CH2)1-C(O)O-(CH2)5-, -(CH2)1-C(O)O-(CH2)6-, -(CH2)1-C(O)O-(CH2)7-, -(CH2)1-C(O)O-(CH2)8-, -(CH2)1-C(O)O-(CH2)9-, -(CH2)1-C(O)O-(CH2)10-, -(CH2)2-C(O)O-(CH2)1-, -(CH2)2-C(O)O-(CH2)2-, -(CH2)2-C(O)O-(CH2)3-, -(CH2)2-C(O)O-(CH2)4-, -(CH2)2-C(O)O-(CH2)5-, -(CH2)2-C(O)O-(CH2)6-, -(CH2)2-C(O)O-(CH2)7-, -(CH2)2-C(O)O-(CH2)8-, -(CH2)2-C(O)O-(CH2)9-, -(CH2)2-C(O)O-(CH2)10-, -(CH2)2-C(O)O-(CH2)11-, -(CH2)2-C(O)O-(CH2)12-, -(CH2)3-C(O)O-(CH2)1-, -(CH2)3-C(O)O-(CH2)2-, -(CH2)3-C(O)O-(CH2)3-, -(CH2)3-C(O)O-(CH2)4-, -(CH2)3-C(O)O-(CH2)5-, -(CH2)3-C(O)O-(CH2)6-, -(CH2)3-C(O)O-(CH2)7-, -(CH2)4-C(O)O-(CH2)1-, -(CH2)4-C(O)O-(CH2)2-, -(CH2)4-C(O)O-(CH2)3-, -(CH2)4-C(O)O-(CH2)4-, -(CH2)4-C(O)O-(CH2)5-, -(CH2)4-C(O)O-(CH2)6-, -(CH2)5-C(O)O-(CH2)1-, -(CH2)5-C(O)O-(CH2)2-, -(CH2)5-C(O)O-(CH2)3-, -(CH2)5-C(O)O-(CH2)4-, -(CH2)5-C(O)O-(CH2)5-, -(CH2)6-C(O)O-(CH2)1-, -(CH2)6-C(O)O-(CH2)2-, -(CH2)6-C(O)O-(CH2)3-, -(CH2)6-C(O)O-(CH2)4-, -(CH2)7-C(O)O-(CH2)1-, -(CH2)7-C(O)O-(CH2)2-, -(CH2)7-C(O)O-(CH2)3-, -(CH2)8-C(O)O-(CH2)1-, -(CH2)8-C(O)O-(CH2)2-, -CH2-OC(O)-CH2-, -CH2-OC(O)-(CH2)2-, -(CH2)1-OC(O)-(CH2)3-, - (CH2)1-OC(O)-(CH2)4-, -(CH2)1-OC(O)-(CH2)5-, -(CH2)1-OC(O)-(CH2)6-, -(CH2)1-OC(O)-(CH2)7-, - (CH2)1-OC(O)-(CH2)8-, -(CH2)1-OC(O)-(CH2)9-, -(CH2)1-OC(O)-(CH2)10-, -(CH2)2-OC(O)-(CH2)1-, - (CH2)2-OC(O)-(CH2)2-, -(CH2)2-OC(O)-(CH2)3-, -(CH2)2-OC(O)-(CH2)4-, -(CH2)2-OC(O)-(CH2)5-,-(CH2)2-OC(O)-(CH2)6-, -(CH2)2-OC(O)-(CH2)7-, -(CH2)2-OC(O)-(CH2)8-, -(CH2)2-OC(O)-(CH2)9-, - (CH2)2-OC(O)-(CH2)10-, -(CH2)2-OC(O)-(CH2)11-, -(CH2)2-OC(O)-(CH2)12-, -(CH2)3-OC(O)-(CH2)1-, - (CH2)3-OC(O)-(CH2)2-, -(CH2)3-OC(O)-(CH2)3-, -(CH2)3-OC(O)-(CH2)4-, -(CH2)3-OC(O)-(CH2)5-, - (CH2)3-OC(O)-(CH2)6-, -(CH2)3-OC(O)-(CH2)7-, -(CH2)4-OC(O)-(CH2)1-, -(CH2)4-OC(O)-(CH2)2-, - (CH2)4-OC(O)-(CH2)3-, -(CH2)4-OC(O)-(CH2)4-, -(CH2)4-OC(O)-(CH2)5-, -(CH2)4-OC(O)-(CH2)6-,-(CH2)5-OC(O)-(CH2)1-, -(CH2)5-OC(O)-(CH2)2-, -(CH2)5-OC(O)-(CH2)3-, -(CH2)5-OC(O)-(CH2)4-, - (CH2)5-OC(O)-(CH2)5-, -(CH2)6-OC(O)-(CH2)1-, -(CH2)6-OC(O)-(CH2)2-, -(CH2)6-OC(O)-(CH2)3-, - (CH2)6-OC(O)-(CH2)4-, -(CH2)7-OC(O)-(CH2)1-, -(CH2)7-OC(O)-(CH2)2-, -(CH2)7-OC(O)-(CH2)3-, - (CH2)8-OC(O)-(CH2)1-, -(CH2)8-OC(O)-(CH2)2-, -(CH2)1-N(Rg11)-(CH2)1-, -(CH2)1-N(Rg11)-(CH2)2-, - (CH2)1-N(Rg11)-(CH2)3-, -(CH2)1-N(Rg11)-(CH2)4-, -(CH2)1-N(Rg11)-(CH2)5-, -(CH2)1-N(Rg11)-(CH2)6-, - (CH2)1-N(Rg11)-(CH2)7-, -(CH2)1-N(Rg11)-(CH2)8-, -(CH2)1-N(Rg11)-(CH2)9-, -(CH2)1-N(Rg11)-(CH2)10-, -(CH2)2-N(Rg11)-(CH2)1-, -(CH2)2-N(Rg11)-(CH2)2-, -(CH2)2-N(Rg11)-(CH2)3-, -(CH2)2-N(Rg11)-(CH2)4-, -(CH2)2-N(Rg11)-(CH2)5-, -(CH2)2-N(Rg11)-(CH2)6-, -(CH2)2-N(Rg11)-(CH2)7-, -(CH2)2-N(Rg11)-(CH2)8-, -(CH2)2-N(Rg11)-(CH2)9-, -(CH2)2-N(Rg11)-(CH2)10-, -(CH2)2-N(Rg11)-(CH2)11-, -(CH2)2-N(Rg11)-(CH2)12-, -(CH2)3-N(Rg11)-(CH2)1-, -(CH2)3-N(Rg11)-(CH2)2-, -(CH2)3-N(Rg11)-(CH2)3-, -(CH2)4-N(Rg11)-(CH2)1-, -(CH2)4-N(Rg11)-(CH2)2-, -(CH2)4-N(Rg11)-(CH2)3-, -(CH2)4-N(Rg11)-(CH2)4-, -(CH2)5-N(Rg11)-(CH2)1-, -(CH2)5-N(Rg11)-(CH2)2-, -(CH2)5-N(Rg11)-(CH2)3-, -(CH2)5-N(Rg11)-(CH2)4-, -(CH2)5-N(Rg11)-(CH2)5-, -(CH2)6-N(Rg11)-(CH2)1-, -(CH2)6-N(Rg11)-(CH2)2-, -(CH2)6-N(Rg11)-(CH2)3-, -(CH2)7-N(Rg11)-(CH2)1-, -(CH2)7-N(Rg11)-(CH2)2-, -(CH2)7-N(Rg11)-(CH2)3-, -(CH2)8-N(Rg11)-(CH2)1-, -(CH2)8-NRg11)-(CH2)2-, -(CH2)8-N(Rg11)-(CH2)3-, -CH(CH3)-N(Rg11)-(CH2)1-, -CH(CH3)-N(Rg11)-(CH2)2-, - CH(CH3)-N(Rg11)-(CH2)3-, -CH(CH3)-N(Rg11)-(CH2)4-, -CH(CH3)-N(Rg11)-(CH2)5-, -CH(CH3)-N(Rg11)-(CH2)6-, -CH(CH3)-N(Rg11)-(CH2)7-, -CH(CH3)-N(Rg11)-(CH2)8-, -CH(CH3)-N(Rg11)-(CH2)9-, -CH(CH3)-N(Rg11)-(CH2)10-, -CH2C(O)NHCH2-, -(CH2)2C(O)NH(CH2)2-, -(CH2)2C(O)NH(CH2)3-, - (CH2)2C(O)NH(CH2)4-, -(CH2)2C(O)NH(CH2)5-, -(CH2)3C(O)NH(CH2)3-, -(CH2)3C(O)NH(CH2)4-, - (CH2)4C(O)NH(CH2)4-, -(CH2)5C(O)NH(CH2)5-, -(CH2)6C(O)NH(CH2)7-, -(CH2)6C(O)NH(CH2)6-,-(CH2)7C(O)NH(CH2)7-, -(CH2)8C(O)NH(CH2)8, -(CH2)9C(O)NH(CH2)9-, -(CH2)10C(O)NH(CH2)10-, - (CH2)2C(O)NH(CH2)2-O-(CH2)2-, -CH2NHC(O)CH2-, -(CH2)2NHC(O)(CH2)2-, - (CH2)2NHC(O)(CH2)3-, -(CH2)2NHC(O)(CH2)4-, -(CH2)2NHC(O)(CH2)5-, -(CH2)3NHC(O)(CH2)3-, - (CH2)3NHC(O)(CH2)4-, -(CH2)4NHC(O)(CH2)4-, -(CH2)5NHC(O)(CH2)5-, -(CH2)6NHC(O)(CH2)7-, - (CH2)6NHC(O)(CH2)6-, -(CH2)7NHC(O)(CH2)7-, -(CH2)8NHC(O)(CH2)8, -(CH2)9NHC(O)(CH2)9-, - (CH2)10NHC(O)(CH2)10-, -(CH2)4NHC(O)(CH2)8-, -(CH2)2NHC(O)(CH2)2-O-(CH2)2-, - (CH2)4NHC(O)CH2-, -CH2-piperidinylene-CH2-, -CH2-piperidinylene-(CH2)2-, -CH2-piperidinylene-(CH2)3-, -CH2-piperidinylene-(CH2)4-, -CH2-piperidinylene-(CH2)5-, -CH2-piperidinylene-(CH2)6-, - CH2-piperidinylene-(CH2)7-, -CH2-piperidinylene-(CH2)8-, -(CH2)2-piperidinylene-(CH2)1-, -(CH2)2-piperidinylene-(CH2)2-, -(CH2)2-piperidinylene-(CH2)3-, -(CH2)2-piperidinylene-(CH2)4-, -(CH2)2-piperidinylene-(CH2)5-, -(CH2)2-piperidinylene-(CH2)6-, -(CH2)2-piperidinylene-(CH2)7-, -(CH2)2-piperidinylene-(CH2)8-, -(CH2)3-piperidinylene-CH2-, -(CH2)3-piperidinylene-(CH2)2-, -(CH2)3-piperidinylene-(CH2)3-, -(CH2)3-piperidinylene-(CH2)4-, -(CH2)3-piperidinylene-(CH2)5-, -(CH2)3-piperidinylene-(CH2)6-, -(CH2)3-piperidinylene-(CH2)7-, -(CH2)3-piperidinylene-(CH2)8-, -(CH2)4-piperidinylene-CH2-, -(CH2)4-piperidinylene-(CH2)2-, -(CH2)4-piperidinylene-(CH2)3-, -(CH2)4-piperidinylene-(CH2)4-, -(CH2)4-piperidinylene-(CH2)5-, -(CH2)4-piperidinylene-(CH2)6-, -(CH2)4-piperidinylene-(CH2)7-, -(CH2)4-piperidinylene-(CH2)8-, -(CH2)5-piperidinylene-(CH2)1-, -(CH2)5-piperidinylene-(CH2)2-, -(CH2)5-piperidinylene-(CH2)3-, -(CH2)5-piperidinylene-(CH2)4-, -(CH2)5-piperidinylene-(CH2)5-, -(CH2)5-piperidinylene-(CH2)6-, -(CH2)5-piperidinylene-(CH2)7-, -(CH2)5-piperidinylene-(CH2)8-, -(CH2)6-piperidinylene-(CH2)1-, -(CH2)6-piperidinylene-(CH2)2-, -(CH2)6-piperidinylene-(CH2)3-, -(CH2)6-piperidinylene-(CH2)4-, -(CH2)6-piperidinylene-(CH2)5-, -(CH2)6-piperidinylene-(CH2)6-, -(CH2)6-piperidinylene-(CH2)7-, -(CH2)6-piperidinylene-(CH2)8-, -(CH2)7-piperidinylene-(CH2)1-, -(CH2)7-piperidinylene-(CH2)2-, -(CH2)7-piperidinylene-(CH2)3-, -(CH2)7-piperidinylene-(CH2)4-, -(CH2)7-piperidinylene-(CH2)8-, -(CH2)8-piperidinylene-CH2-, -(CH2)8-piperidinylene-(CH2)2-, -(CH2)8-piperidinylene-(CH2)3-, -(CH2)8-piperidinylene-(CH2)4-, -(CH2)8-piperidinylene-(CH2)5-, -(CH2)8-piperidinylene-(CH2)6-, -(CH2)8-piperidinylene-(CH2)7-, -(CH2)8-piperidinylene-(CH2)8-, -CH2-piperazinylene-CH2-, -CH2-piperazinylene-(CH2)2-, -CH2-piperazinylene-(CH2)3-, -CH2-piperazinylene-(CH2)4-, -CH2-piperazinylene-(CH2)5-, -CH2-piperazinylene-(CH2)6-, -CH2-piperazinylene-(CH2)7-, -CH2-piperazinylene-(CH2)8-, -(CH2)2-piperazinylene-(CH2)1-, -(CH2)2-piperazinylene-(CH2)2-, -(CH2)2-piperazinylene-(CH2)3-, -(CH2)2-piperazinylene-(CH2)4-, -(CH2)2-piperazinylene-(CH2)5-, -(CH2)2-piperazinylene-(CH2)6-, -(CH2)2-piperazinylene-(CH2)7-, -(CH2)2-piperazinylene-(CH2)8-, -(CH2)3-piperazinylene-CH2-, -(CH2)3-piperazinylene-(CH2)2-, -(CH2)3-piperazinylene-(CH2)3-, -(CH2)3-piperazinylene-(CH2)4-, -(CH2)3-piperazinylene-(CH2)5-, -(CH2)3-piperazinylene-(CH2)6-, -(CH2)3-piperazinylene-(CH2)7-, -(CH2)3-piperazinylene-(CH2)8-, -(CH2)4-piperazinylene-CH2-, -(CH2)4-piperazinylene-(CH2)2-, -(CH2)4-piperazinylene-(CH2)3-, -(CH2)4-piperazinylene-(CH2)4-, -(CH2)4-piperazinylene-(CH2)5-, -(CH2)4-piperazinylene-(CH2)6-, -(CH2)4-piperazinylene-(CH2)7-, -(CH2)4-piperazinylene-(CH2)8-, -(CH2)5-piperazinylene-(CH2)1-, -(CH2)5-piperazinylene-(CH2)2-, -(CH2)5-piperazinylene-(CH2)3-, -(CH2)5-piperazinylene-(CH2)4-, -(CH2)5-piperazinylene-(CH2)5-, -(CH2)5-piperazinylene-(CH2)6-, -(CH2)5-piperazinylene-(CH2)7-, -(CH2)5-piperazinylene-(CH2)8-, -(CH2)6-piperazinylene-(CH2)1-, -(CH2)6-piperazinylene-(CH2)2-, -(CH2)6-piperazinylene-(CH2)3-, -(CH2)6-piperazinylene-(CH2)4-, -(CH2)6-piperazinylene-(CH2)5-, -(CH2)6-piperazinylene-(CH2)6-, -(CH2)6-piperazinylene-(CH2)7-, -(CH2)6-piperazinylene-(CH2)8-, -(CH2)7-piperazinylene-(CH2)1-, -(CH2)7-piperazinylene-(CH2)2-, -(CH2)7-piperazinylene-(CH2)3-, -(CH2)7-piperazinylene-(CH2)4-, -(CH2)7-piperazinylene-(CH2)8-, -(CH2)8-piperazinylene-CH2-, -(CH2)8-piperazinylene-(CH2)2-, -(CH2)8-piperazinylene-(CH2)3-, -(CH2)8-piperazinylene-(CH2)4-, -(CH2)8-piperazinylene-(CH2)5-, -(CH2)8-piperazinylene-(CH2)6-, -(CH2)8-piperazinylene-(CH2)7-, -(CH2)8-piperazinylene-(CH2)8-, -CH2-propylene-CH2-, -CH2-propylene-(CH2)2-, -CH2-propylene-(CH2)3-, -CH2-propylene-(CH2)4-, -CH2-propylene-(CH2)5-, -CH2-propylene-(CH2)6-, -CH2-propylene-(CH2)7-, -CH2-propylene-(CH2)8-, -(CH2)2-propylene-(CH2)1-, -(CH2)2-propylene-(CH2)2-, -(CH2)2-propylene-(CH2)3-, -(CH2)2-propylene-(CH2)4-, -(CH2)2-propylene-(CH2)5-, -(CH2)2-propylene-(CH2)6-, -(CH2)2-propylene-(CH2)7-, -(CH2)2-propylene-(CH2)8-, -(CH2)3-propylene-CH2-, -(CH2)3-propylene-(CH2)2-, -(CH2)3-propylene-(CH2)3-, -(CH2)3-propylene-(CH2)4-, - (CH2)3-propylene-(CH2)5-, -(CH2)3-propylene-(CH2)6-, -(CH2)3-propylene-(CH2)7-, -(CH2)3-propylene-(CH2)8-, -(CH2)4-propylene-CH2-, -(CH2)4-propylene-(CH2)2-, -(CH2)4-propylene-(CH2)3-, -(CH2)4-propylene-(CH2)4-, -(CH2)4-propylene-(CH2)5-, -(CH2)4-propylene-(CH2)6-, -(CH2)4-propylene-(CH2)7-, -(CH2)4-propylene-(CH2)8-, -(CH2)5-propylene-(CH2)1-, -(CH2)5-propylene-(CH2)2-, -(CH2)5-propylene-(CH2)3-, -(CH2)5-propylene-(CH2)4-, -(CH2)5-propylene-(CH2)5-, -(CH2)5-propylene-(CH2)6-, -(CH2)5-propylene-(CH2)7-, -(CH2)5-propylene-(CH2)8-, -(CH2)6-propylene-(CH2)1-, -(CH2)6-propylene-(CH2)2-, -(CH2)6-propylene-(CH2)3-, -(CH2)6-propylene-(CH2)4-, -(CH2)6-propylene-(CH2)5-, -(CH2)6-propylene-(CH2)6-, -(CH2)6-propylene-(CH2)7-, -(CH2)6-propylene-(CH2)8-, -(CH2)7-propylene-(CH2)1-, -(CH2)7-propylene-(CH2)2-, -(CH2)7-propylene-(CH2)3-, -(CH2)7-propylene-(CH2)4-, -(CH2)7-propylene-(CH2)8-, -(CH2)8-propylene-CH2-, -(CH2)8-propylene-(CH2)2-, -(CH2)8-propylene-(CH2)3-, -(CH2)8-propylene-(CH2)4-, -(CH2)8-propylene-(CH2)5-, -(CH2)8-propylene-(CH2)6-, -(CH2)8-propylene-(CH2)7-, -(CH2)8-propylene-(CH2)8-, -CH2-diazacycloheptanylene-CH2-, -CH2-diazacycloheptanylene-(CH2)2-, -CH2-diazacycloheptanylene-(CH2)3-, -CH2-diazacycloheptanylene-(CH2)4-, -CH2-diazacycloheptanylene-(CH2)5-, -CH2-diazacycloheptanylene-(CH2)6-, -CH2-diazacycloheptanylene-(CH2)7-, -CH2-diazacycloheptanylene-(CH2)8-, -(CH2)2-diazacycloheptanylene-(CH2)1-, -(CH2)2-diazacycloheptanylene-(CH2)2-, -(CH2)2-diazacycloheptanylene-(CH2)3-, -(CH2)2-diazacycloheptanylene-(CH2)4-, -(CH2)2-diazacycloheptanylene-(CH2)5-, -(CH2)2-diazacycloheptanylene-(CH2)6-, -(CH2)2-diazacycloheptanylene-(CH2)7-, -(CH2)2-diazacycloheptanylene-(CH2)8-, -(CH2)3-diazacycloheptanylene-CH2-, -(CH2)3-diazacycloheptanylene-(CH2)2-, -(CH2)3-diazacycloheptanylene-(CH2)3-, -(CH2)3-diazacycloheptanylene-(CH2)4-, -(CH2)3-diazacycloheptanylene-(CH2)5-, -(CH2)3-diazacycloheptanylene-(CH2)6-, -(CH2)3-diazacycloheptanylene-(CH2)7-, -(CH2)3-diazacycloheptanylene-(CH2)8-, -(CH2)4-diazacycloheptanylene-CH2-, -(CH2)4-diazacycloheptanylene-(CH2)2-, -(CH2)4-diazacycloheptanylene-(CH2)3-, -(CH2)4-diazacycloheptanylene-(CH2)4-, -(CH2)4-diazacycloheptanylene-(CH2)5-, -(CH2)4-diazacycloheptanylene-(CH2)6-, -(CH2)4-diazacycloheptanylene-(CH2)7-, -(CH2)4-diazacycloheptanylene-(CH2)8-, -(CH2)5-diazacycloheptanylene-(CH2)1-, -(CH2)5-diazacycloheptanylene-(CH2)2-, -(CH2)5-diazacycloheptanylene-(CH2)3-, -(CH2)5-diazacycloheptanylene-(CH2)4-, -(CH2)5-diazacycloheptanylene-(CH2)5-, -(CH2)5-diazacycloheptanylene-(CH2)6-, -(CH2)5-diazacycloheptanylene-(CH2)7-, -(CH2)5-diazacycloheptanylene-(CH2)8-, -(CH2)6-diazacycloheptanylene-(CH2)1-, -(CH2)6-diazacycloheptanylene-(CH2)2-, -(CH2)6-diazacycloheptanylene-(CH2)3-, -(CH2)6-diazacycloheptanylene-(CH2)4-, -(CH2)6-diazacycloheptanylene-(CH2)5-, -(CH2)6-diazacycloheptanylene-(CH2)6-, -(CH2)6-diazacycloheptanylene-(CH2)7-, -(CH2)6-diazacycloheptanylene-(CH2)8-, -(CH2)7-diazacycloheptanylene-(CH2)1-, -(CH2)7-diazacycloheptanylene-(CH2)2-, -(CH2)7-diazacycloheptanylene-(CH2)3-, -(CH2)7-diazacycloheptanylene-(CH2)4-, -(CH2)7-diazacycloheptanylene-(CH2)8-, -(CH2)8-diazacycloheptanylene-CH2-, -(CH2)8-diazacycloheptanylene-(CH2)2-, -(CH2)8-diazacycloheptanylene-(CH2)3-, -(CH2)8-diazacycloheptanylene-(CH2)4-, -(CH2)8-diazacycloheptanylene-(CH2)5-, -(CH2)8-diazacycloheptanylene-(CH2)6-, -(CH2)8-diazacycloheptanylene-(CH2)7-, -(CH2)8-diazacycloheptanylene-(CH2)8-, -CH2-diazabicyclo[2.2.1]heptanylene-CH2-, -CH2-diazabicyclo[2.2.1]heptanylene-(CH2)2-, -CH2-diazabicyclo[2.2.1]heptanylene-(CH2)3-, -CH2-diazabicyclo[2.2.1]heptanylene-(CH2)4-, -CH2-diazabicyclo[2.2.1]heptanylene-(CH2)5-, -CH2-diazabicyclo[2.2.1]heptanylene-(CH2)6-, -CH2-diazabicyclo[2.2.1]heptanylene-(CH2)7-, -CH2-diazabicyclo[2.2.1]heptanylene-(CH2)8-, -(CH2)2-diazabicyclo[2.2.1]heptanylene-(CH2)1-, -(CH2)2-diazabicyclo[2.2.1]heptanylene-(CH2)2-, -(CH2)2-diazabicyclo[2.2.1]heptanylene-(CH2)3-, -(CH2)2-diazabicyclo[2.2.1]heptanylene-(CH2)4-, -(CH2)2-diazabicyclo[2.2.1]heptanylene-(CH2)5-, -(CH2)2-diazabicyclo[2.2.1]heptanylene-(CH2)6-, -(CH2)2-diazabicyclo[2.2.1]heptanylene-(CH2)7-, -(CH2)2-diazabicyclo[2.2.1]heptanylene-(CH2)8-, -(CH2)3-diazabicyclo[2.2.1]heptanylene-CH2-, -(CH2)3-diazabicyclo[2.2.1]heptanylene-(CH2)2-, -(CH2)3-diazabicyclo[2.2.1]heptanylene-(CH2)3-, -(CH2)3-diazabicyclo[2.2.1]heptanylene-(CH2)4-, -(CH2)3-diazabicyclo[2.2.1]heptanylene-(CH2)5-, -(CH2)3-diazabicyclo[2.2.1]heptanylene-(CH2)6-, -(CH2)3-diazabicyclo[2.2.1]heptanylene-(CH2)7-, -(CH2)3-diazabicyclo[2.2.1]heptanylene-(CH2)8-, -(CH2)4-diazabicyclo[2.2.1]heptanylene-CH2-, -(CH2)4-diazabicyclo[2.2.1]heptanylene-(CH2)2-, -(CH2)4-diazabicyclo[2.2.1]heptanylene-(CH2)3-, -(CH2)4-diazabicyclo[2.2.1]heptanylene-(CH2)4-, -(CH2)4-diazabicyclo[2.2.1]heptanylene-(CH2)5-, -(CH2)4-diazabicyclo[2.2.1]heptanylene-(CH2)6-, -(CH2)4-diazabicyclo[2.2.1]heptanylene-(CH2)7-, -(CH2)4-diazabicyclo[2.2.1]heptanylene-(CH2)8-, -(CH2)5-diazabicyclo[2.2.1]heptanylene-(CH2)1-, -(CH2)5-diazabicyclo[2.2.1]heptanylene-(CH2)2-, -(CH2)5-diazabicyclo[2.2.1]heptanylene-(CH2)3-, -(CH2)5-diazabicyclo[2.2.1]heptanylene-(CH2)4-, -(CH2)5-diazabicyclo[2.2.1]heptanylene-(CH2)5-, -(CH2)5-diazabicyclo[2.2.1]heptanylene-(CH2)6-, -(CH2)5-diazabicyclo[2.2.1]heptanylene-(CH2)7-, -(CH2)5-diazabicyclo[2.2.1]heptanylene-(CH2)8-, -(CH2)6-diazabicyclo[2.2.1]heptanylene-(CH2)1-, -(CH2)6-diazabicyclo[2.2.1]heptanylene-(CH2)2-, -(CH2)6-diazabicyclo[2.2.1]heptanylene-(CH2)3-, -(CH2)6-diazabicyclo[2.2.1]heptanylene-(CH2)4-, -(CH2)6-diazabicyclo[2.2.1]heptanylene-(CH2)5-, -(CH2)6-diazabicyclo[2.2.1]heptanylene-(CH2)6-, -(CH2)6-diazabicyclo[2.2.1]heptanylene-(CH2)7-, -(CH2)6-diazabicyclo[2.2.1]heptanylene-(CH2)8-, -(CH2)7-diazabicyclo[2.2.1]heptanylene-(CH2)1-, -(CH2)7-diazabicyclo[2.2.1]heptanylene-(CH2)2-, -(CH2)7-diazabicyclo[2.2.1]heptanylene-(CH2)3-, -(CH2)7-diazabicyclo[2.2.1]heptanylene-(CH2)4-, -(CH2)7-diazabicyclo[2.2.1]heptanylene-(CH2)8-, -(CH2)8-diazabicyclo[2.2.1]heptanylene-CH2-, -(CH2)8-diazabicyclo[2.2.1]heptanylene-(CH2)2-, -(CH2)8-diazabicyclo[2.2.1]heptanylene-(CH2)3-, -(CH2)8-diazabicyclo[2.2.1]heptanylene-(CH2)4-, -(CH2)8-diazabicyclo[2.2.1]heptanylene-(CH2)5-, -(CH2)8-diazabicyclo[2.2.1]heptanylene-(CH2)6-, -(CH2)8-diazabicyclo[2.2.1]heptanylene-(CH2)7-, -(CH2)8-diazabicyclo[2.2.1]heptanylene-(CH2)8-, -CH2-diazabicyclo[3.1.1]heptanylene-CH2-, -CH2-diazabicyclo[3.1.1]heptanylene-(CH2)2-, -CH2-diazabicyclo[3.1.1]heptanylene-(CH2)3-, -CH2-diazabicyclo[3.1.1]heptanylene-(CH2)4-, -CH2-diazabicyclo[3.1.1]heptanylene-(CH2)5-, -CH2-diazabicyclo[3.1.1]heptanylene-(CH2)6-, -CH2-diazabicyclo[3.1.1]heptanylene-(CH2)7-, -CH2-diazabicyclo[3.1.1]heptanylene-(CH2)8-, -(CH2)2-diazabicyclo[3.1.1]heptanylene-(CH2)1-, -(CH2)2-diazabicyclo[3.1.1]heptanylene-(CH2)2-, -(CH2)2-diazabicyclo[3.

1. 1]heptanylene-(CH2)3-, -(CH2)2-diazabicyclo[3.

1. 1]heptanylene-(CH2)4-, -(CH2)2-diazabicyclo[3.

1. 1]heptanylene-(CH2)5-, -(CH2)2-diazabicyclo[3.

1. 1]heptanylene-(CH2)6-, -(CH2)2-diazabicyclo[3.

1. 1]heptanylene-(CH2)7-, -(CH2)2-diazabicyclo[3.

1. 1]heptanylene-(CH2)8-, -(CH2)3-diazabicyclo[3.1.1]heptanylene-CH2-, -(CH2)3-diazabicyclo[3.1.1]heptanylene-(CH2)2-, -(CH2)3-diazabicyclo[3.1.1]heptanylene-(CH2)3-, -(CH2)3-diazabicyclo[3.1.1]heptanylene-(CH2)4-, -(CH2)3-diazabicyclo[3.1.1]heptanylene-(CH2)5-, -(CH2)3-diazabicyclo[3.1.1]heptanylene-(CH2)6-, -(CH2)3-diazabicyclo[3.1.1]heptanylene-(CH2)7-, -(CH2)3-diazabicyclo[3.1.1]heptanylene-(CH2)8-, -(CH2)4-diazabicyclo[3.1.1]heptanylene-CH2-, -(CH2)4-diazabicyclo[3.1.1]heptanylene-(CH2)2-, -(CH2)4-diazabicyclo[3.1.1]heptanylene-(CH2)3-, -(CH2)4-diazabicyclo[3.1.1]heptanylene-(CH2)4-, -(CH2)4-diazabicyclo[3.

1. 1]heptanylene-(CH2)5-, -(CH2)4-diazabicyclo[3.

1. 1]heptanylene-(CH2)6-, -(CH2)4-diazabicyclo[3.

1. 1]heptanylene-(CH2)7-, -(CH2)4-diazabicyclo[3.

1. 1]heptanylene-(CH2)8-, -(CH2)5-diazabicyclo[3.1.1]heptanylene-(CH2)1-, -(CH2)5-diazabicyclo[3.1.1]heptanylene-(CH2)2-, -(CH2)5-diazabicyclo[3.1.1]heptanylene-(CH2)3-, -(CH2)5-diazabicyclo[3.1.1]heptanylene-(CH2)4-, -(CH2)5-diazabicyclo[3.1.1]heptanylene-(CH2)5-, -(CH2)5-diazabicyclo[3.1.1]heptanylene-(CH2)6-, -(CH2)5-diazabicyclo[3.1.1]heptanylene-(CH2)7-, -(CH2)5-diazabicyclo[3.1.1]heptanylene-(CH2)8-, -(CH2)6-diazabicyclo[3.1.1]heptanylene-(CH2)1-, -(CH2)6-diazabicyclo[3.1.1]heptanylene-(CH2)2-, -(CH2)6-diazabicyclo[3.1.1]heptanylene-(CH2)3-, -(CH2)6-diazabicyclo[3.1.1]heptanylene-(CH2)4-, -(CH2)6-diazabicyclo[3.

1. 1]heptanylene-(CH2)5-, -(CH2)6-diazabicyclo[3.

1. 1]heptanylene-(CH2)6-, -(CH2)6-diazabicyclo[3.

1. 1]heptanylene-(CH2)7-, -(CH2)6-diazabicyclo[3.

1. 1]heptanylene-(CH2)8-, -(CH2)7-diazabicyclo[3.1.1]heptanylene-(CH2)1-, -(CH2)7-diazabicyclo[3.1.1]heptanylene-(CH2)2-, -(CH2)7-diazabicyclo[3.1.1]heptanylene-(CH2)3-, -(CH2)7-diazabicyclo[3.1.1]heptanylene-(CH2)4-, -(CH2)7-diazabicyclo[3.1.1]heptanylene-(CH2)8-, -(CH2)8-diazabicyclo[3.1.1]heptanylene-CH2-, -(CH2)8-diazabicyclo[3.1.1]heptanylene-(CH2)2-, -(CH2)8-diazabicyclo[3.1.1]heptanylene-(CH2)3-, -(CH2)8-diazabicyclo[3.1.1]heptanylene-(CH2)4-, -(CH2)8-diazabicyclo[3.1.1]heptanylene-(CH2)5-, -(CH2)8-diazabicyclo[3.1.1]heptanylene-(CH2)6-, -(CH2)8-diazabicyclo[3.1.1]heptanylene-(CH2)7-, -(CH2)8-diazabicyclo[3.

1. 1]heptanylene-(CH2)8-, -CH2-diazabicyclo[3.2.1]octylene-CH2-, -CH2-diazabicyclo[3.

2. 1]octylene-(CH2)2-, -CH2-diazabicyclo[3.2.1]octylene-(CH2)3-, -CH2-diazabicyclo[3.

2. 1]octylene-(CH2)4-, -CH2-diazabicyclo[3.2.1]octylene-(CH2)5-, -CH2-diazabicyclo[3.

2. 1]octylene-(CH2)6-, -CH2-diazabicyclo[3.2.1]octylene-(CH2)7-, -CH2-diazabicyclo[3.2.1]octylene-(CH2)8-, -(CH2)2-diazabicyclo[3.2.1]octylene-(CH2)1-, -(CH2)2-diazabicyclo[3.2.1]octylene-(CH2)2-, -(CH2)2-diazabicyclo[3.2.1]octylene-(CH2)3-, -(CH2)2-diazabicyclo[3.2.1]octylene-(CH2)4-, -(CH2)2-diazabicyclo[3.2.1]octylene-(CH2)5-, -(CH2)2-diazabicyclo[3.2.1]octylene-(CH2)6-, -(CH2)2-diazabicyclo[3.2.1]octylene-(CH2)7-, -(CH2)2-diazabicyclo[3.

2. 1]octylene-(CH2)8-, -(CH2)3-diazabicyclo[3.2.1]octylene-CH2-, -(CH2)3-diazabicyclo[3.

2. 1]octylene-(CH2)2-, -(CH2)3-diazabicyclo[3.2.1]octylene-(CH2)3-, -(CH2)3-diazabicyclo[3.

2. 1]octylene-(CH2)4-, -(CH2)3-diazabicyclo[3.2.1]octylene-(CH2)5-, -(CH2)3-diazabicyclo[3.2.1]octylene-(CH2)6-, -(CH2)3-diazabicyclo[3.2.1]octylene-(CH2)7-, -(CH2)3-diazabicyclo[3.2.1]octylene-(CH2)8-, -(CH2)4-diazabicyclo[3.2.1]octylene-CH2-, -(CH2)4-diazabicyclo[3.2.1]octylene-(CH2)2-, -(CH2)4-diazabicyclo[3.2.1]octylene-(CH2)3-, -(CH2)4-diazabicyclo[3.2.1]octylene-(CH2)4-, -(CH2)4-diazabicyclo[3.2.1]octylene-(CH2)5-, -(CH2)4-diazabicyclo[3.2.1]octylene-(CH2)6-, -(CH2)4-diazabicyclo[3.2.1]octylene-(CH2)7-, -(CH2)4-diazabicyclo[3.2.1]octylene-(CH2)8-, -(CH2)5-diazabicyclo[3.2.1]octylene-(CH2)1-, -(CH2)5-diazabicyclo[3.2.1]octylene-(CH2)2-, -(CH2)5-diazabicyclo[3.2.1]octylene-(CH2)3-, -(CH2)5-diazabicyclo[3.2.1]octylene-(CH2)4-, -(CH2)5-diazabicyclo[3.2.1]octylene-(CH2)5-, -(CH2)5-diazabicyclo[3.2.1]octylene-(CH2)6-, -(CH2)5-diazabicyclo[3.2.1]octylene-(CH2)7-, -(CH2)5-diazabicyclo[3.2.1]octylene-(CH2)8-, -(CH2)6-diazabicyclo[3.2.1]octylene-(CH2)1-, -(CH2)6-diazabicyclo[3.2.1]octylene-(CH2)2-, -(CH2)6-diazabicyclo[3.2.1]octylene-(CH2)3-, -(CH2)6-diazabicyclo[3.2.1]octylene-(CH2)4-, -(CH2)6-diazabicyclo[3.2.1]octylene-(CH2)5-, -(CH2)6-diazabicyclo[3.2.1]octylene-(CH2)6-, -(CH2)6-diazabicyclo[3.2.1]octylene-(CH2)7-, -(CH2)6-diazabicyclo[3.2.1]octylene-(CH2)8-, -(CH2)7-diazabicyclo[3.2.1]octylene-(CH2)1-, -(CH2)7-diazabicyclo[3.2.1]octylene-(CH2)2-, -(CH2)7-diazabicyclo[3.2.1]octylene-(CH2)3-, -(CH2)7-diazabicyclo[3.2.1]octylene-(CH2)4-, -(CH2)7-diazabicyclo[3.2.1]octylene-(CH2)8-, -(CH2)8-diazabicyclo[3.2.1]octylene-CH2-, -(CH2)8-diazabicyclo[3.2.1]octylene-(CH2)2-, -(CH2)8-diazabicyclo[3.2.1]octylene-(CH2)3-, -(CH2)8-diazabicyclo[3.2.1]octylene-(CH2)4-, -(CH2)8-diazabicyclo[3.2.1]octylene-(CH2)5-, -(CH2)8-diazabicyclo[3.2.1]octylene-(CH2)6-, -(CH2)8-diazabicyclo[3.2.1]octylene-(CH2)7-, -(CH2)8-diazabicyclo[3.2.1]octylene-(CH2)8-, -CH2-diazabicyclo[2.2.2]octylene-CH2-, -CH2-diazabicyclo[2.2.2]octylene-(CH2)2-, -CH2-diazabicyclo[2.2.2]octylene-(CH2)3-, -CH2-diazabicyclo[2.2.2]octylene-(CH2)4-, -CH2-diazabicyclo[2.2.2]octylene-(CH2)5-, -CH2-diazabicyclo[2.2.2]octylene-(CH2)6-, -CH2-diazabicyclo[2.2.2]octylene-(CH2)7-, -CH2-diazabicyclo[2.2.2]octylene-(CH2)8-, -(CH2)2-diazabicyclo[2.2.2]octylene-(CH2)1-, -(CH2)2-diazabicyclo[2.2.2]octylene-(CH2)2-, -(CH2)2-diazabicyclo[2.2.2]octylene-(CH2)3-, -(CH2)2-diazabicyclo[2.2.2]octylene-(CH2)4-, -(CH2)2-diazabicyclo[2.2.2]octylene-(CH2)5-, -(CH2)2-diazabicyclo[2.2.2]octylene-(CH2)6-, -(CH2)2-diazabicyclo[2.2.2]octylene-(CH2)7-, -(CH2)2-diazabicyclo[2.2.2]octylene-(CH2)8-, -(CH2)3-diazabicyclo[2.2.2]octylene-CH2-, -(CH2)3-diazabicyclo[2.2.2]octylene-(CH2)2-, -(CH2)3-diazabicyclo[2.2.2]octylene-(CH2)3-, -(CH2)3-diazabicyclo[2.2.2]octylene-(CH2)4-, -(CH2)3-diazabicyclo[2.2.2]octylene-(CH2)5-, -(CH2)3-diazabicyclo[2.2.2]octylene-(CH2)6-, -(CH2)3-diazabicyclo[2.2.2]octylene-(CH2)7-, -(CH2)3-diazabicyclo[2.2.2]octylene-(CH2)8-, -(CH2)4-diazabicyclo[2.2.2]octylene-CH2-, -(CH2)4-diazabicyclo[2.2.2]octylene-(CH2)2-, -(CH2)4-diazabicyclo[2.2.2]octylene-(CH2)3-, -(CH2)4-diazabicyclo[2.2.2]octylene-(CH2)4-, -(CH2)4-diazabicyclo[2.2.2]octylene-(CH2)5-, -(CH2)4-diazabicyclo[2.2.2]octylene-(CH2)6-, -(CH2)4-diazabicyclo[2.2.2]octylene-(CH2)7-, -(CH2)4-diazabicyclo[2.2.2]octylene-(CH2)8-, -(CH2)5-diazabicyclo[2.2.2]octylene-(CH2)1-, -(CH2)5-diazabicyclo[2.2.2]octylene-(CH2)2-, -(CH2)5-diazabicyclo[2.2.2]octylene-(CH2)3-, -(CH2)5-diazabicyclo[2.2.2]octylene-(CH2)4-, -(CH2)5-diazabicyclo[2.2.2]octylene-(CH2)5-, -(CH2)5-diazabicyclo[2.2.2]octylene-(CH2)6-, -(CH2)5-diazabicyclo[2.2.2]octylene-(CH2)7-, -(CH2)5-diazabicyclo[2.2.2]octylene-(CH2)8-, -(CH2)6-diazabicyclo[2.2.2]octylene-(CH2)1-, -(CH2)6-diazabicyclo[2.2.2]octylene-(CH2)2-, -(CH2)6-diazabicyclo[2.2.2]octylene-(CH2)3-, -(CH2)6-diazabicyclo[2.2.2]octylene-(CH2)4-, -(CH2)6-diazabicyclo[2.2.2]octylene-(CH2)5-, -(CH2)6-diazabicyclo[2.2.2]octylene-(CH2)6-, -(CH2)6-diazabicyclo[2.2.2]octylene-(CH2)7-, -(CH2)6-diazabicyclo[2.2.2]octylene-(CH2)8-, -(CH2)7-diazabicyclo[2.2.2]octylene-(CH2)1-, -(CH2)7-diazabicyclo[2.2.2]octylene-(CH2)2-, -(CH2)7-diazabicyclo[2.2.2]octylene-(CH2)3-, -(CH2)7-diazabicyclo[2.2.2]octylene-(CH2)4-, -(CH2)7-diazabicyclo[2.2.2]octylene-(CH2)8-, -(CH2)8-diazabicyclo[2.2.2]octylene-CH2-, -(CH2)8-diazabicyclo[2.2.2]octylene-(CH2)2-, -(CH2)8-diazabicyclo[2.2.2]octylene-(CH2)3-, -(CH2)8-diazabicyclo[2.2.2]octylene-(CH2)4-, -(CH2)8-diazabicyclo[2.2.2]octylene-(CH2)5-, -(CH2)8-diazabicyclo[2.2.2]octylene-(CH2)6-, -(CH2)8-diazabicyclo[2.2.2]octylene-(CH2)7-, or -(CH2)8-diazabicyclo[2.2.2]octylene-(CH2)8-, wherein the propylene, the piperidinylene, the piperazinylene, the diazacycloheptanylene, the diazabicyclo[2.2.1]heptanylene, the diazabicyclo[3.1.1]heptanylene, the diazabicyclo[3.2.1]octylene, the diazabicyclo[2.2.2]octylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-4 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH- or any combination thereof; and each Rg11 independently represents H or C1-3 alkyl; or even more preferably, wherein L2 or L3 each independently represent the structure of the following formula:

34. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 1, wherein Rb1 represents: cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptanyl, 2-oxobicyclo[2.2.1]heptanyl or bicyclo[2.2.1]heptenyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof, and wherein the C3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octyl, 2,5-diazabicyclo[2.2.2]octyl, 3-azaspiro[5.5]undecyl or 7-azaspiro[3.5]nonyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof, and wherein the C3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; phenyl or naphthyl, wherein the phenyl or naphthyl is optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof, and wherein the C3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; or furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl and imidazo[2,1-b]thiazolyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15cycloalkyl, optionally substituted 4-to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof, and wherein the C3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; preferably, wherein Rb1 represents: or 35. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 1, wherein Rb2 represents: cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptanyl, 2-oxobicyclo[2.2.1]heptanyl or bicyclo[2.2.1]heptenyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof, and wherein the C3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octyl, 2,5-diazabicyclo[2.2.2]octyl, 3-azaspiro[5.5]undecyl or 7-azaspiro[3.5]nonyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof, and wherein the C3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; phenyl or naphthyl, wherein the phenyl or naphthyl is optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof, and wherein the C3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; or furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl and imidazo[2,1-b]thiazolyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15cycloalkyl, optionally substituted 4-to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof, and wherein the C3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH-, halogenated C1-4 alkyl, NH2-C1-4 alkylene, C1-4 alkyl-NHC(O)-, C1-4 alkyl-C(O)NH-, or any combination thereof; or Rb2 represents the following formula: wherein Rf1, Rf2, Rf3, Rf4 and Rf5 are as defined in claim 13; preferably, wherein Rb2 represents: or 36. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 1, which is selected from the group consisting of: 3-(5-((4-(((3s,5s,7s)-adamantan-1-yl)amino)butyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((5-(((1s,3s)-adamantan-1-yl)amino)pentyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((6-(((3s,5s,7s)-adamantan-1-yl)amino)hexyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((7-(((1s,3s)-adamantan-1-yl)amino)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(2-(((1s,3s)-adamantan-1-yl)amino)ethoxy)ethyl)amino)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((2-(2-(2-(((3s,5s,7s)-adamantan-1-yl)amino)ethoxy)ethoxy)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(((1r,3r,5r,7r)-adamantan-2-yl)amino)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((3-(((1r,3r,5r,7r)-adamantan-2-yl)amino)propyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((4-(((1r,3r,5r,7r)-adamantan-2-yl)amino)butyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((5-(((1r,3r,5r,7r)-adamantan-2-yl)amino)pentyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((5-(((3as,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)pentyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((6-(((2R,3as,5S,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)hexyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((7-(((3as,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(2-(((3as,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)ethoxy)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(2-(2-(((2R,3as,5S,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)ethoxy)ethoxy)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(2-methyl-5-((5-(4-methyl-1,4-diazepan-1-yl)pentyl)amino)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(2-methyl-5-((7-(4-methyl-1,4-diazepan-1-yl)heptyl)amino)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(2-methyl-5-((2-(2-(4-methyl-1,4-diazepan-1-yl)ethoxy)ethyl)amino)-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((2-(2-hydroxyethoxy)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(2-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)ethoxy)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(2-methyl-5-((2-(2-morpholinoethoxy)ethyl)amino)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(2-methyl-5-((2-(2-(4-morpholinopiperidin-1-yl)ethoxy)ethyl)amino)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(2-methyl-5-((2-(2-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)ethoxy)ethyl)amino)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(2-methyl-5-((2-(2-(4-(oxetan-3-yl)piperazin-1-yl)ethoxy)ethyl)amino)-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((7-hydroxyheptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((7-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(2-methyl-5-((7-(4-morpholinopiperidin-1-yl)heptyl)amino)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(2-methyl-5-((7-(4-(oxetan-3-yl)piperazin-1-yl)heptyl)amino)-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((7-(((1 SR,3RS, 5 SR,7r)-3, 5-dimethyladamantan-1-yl)amino)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((7-((1-((3r,5r,7r)-adamantan-1-yl)ethyl)amino)heptyl)amino)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3 -(5 -((7-(3 -azabicyclo [3.1.0]hexan-3 -yl)heptyl)amino)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((7-(2,2-difluoro-7-azaspiro[3.5]nonan-7-yl)heptyl)amino)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((7-((4-fluorobicyclo[2.2.2]octan-1-yl)amino)heptyl)amino)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(2-methyl-4-oxo-5-((7-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)heptyl)amino)quinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((7-((2-isopropyl-5-methylcyclohexyl)oxy)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; (3S)-3-(5-((7-((1-((3r,5r,7r)-adamantan-1-yl)ethyl)amino)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; (S)-3-(5-((7-(((1SR,3RS,SSR,7r)-3,5-dimethyladamantan-1-yl)amino)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; (3R)-3-(5-((7-(((3as,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; (3R)-3 -(5-((7-(((1s,3 s)-adamantan-1-yl)amino)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; (S)-3-(2-methyl-4-oxo-5-((7-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)heptyl)amino)quinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((7-((1-((3r,5r,7r)-adamantan-1-yl)ethyl)amino)heptyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((7-(((1SR,3RS,5SR,7r)-3,5-dimethyladamantan-1-yl)amino)heptyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((7-(4-methyl-1,4-diazepan-1-yl)heptyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((7-(((3as,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)heptyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((2-(2-(2-(((3s,5s,7s)-adamantan-1-yl)amino)ethoxy)ethoxy)ethyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((7-(((1s,3s)-adamantan-1-yl)amino)heptyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((7-((4-fluorobicyclo[2.2.2]octan-1-yl)amino)heptyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((7-(2,2-difluoro-7-azaspiro[3.5]nonan-7-yl)heptyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((7-((2-isopropyl-5-methylcyclohexyl)oxy)heptyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(4-oxo-2-(trifluoromethyl)-5-((7-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)heptyl)amino)quinazolin-3 (4H)-yl)piperidine-2,6-dione; (S)-3-(5-((7-(((1 SR,3RS,SSR,7r)-3,5-dimethyladamantan-1-yl)amino)heptyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3 (4H)-yl)piperidine-2,6-dione; (3 S)-3-(5-((7-((1-((3r,5r,7r)-adamantan-1-yl)ethyl)amino)heptyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3 (4H)-yl)piperidine-2,6-dione; (3R)-3-(5-((7-(((3as,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)heptyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione; (3R)-3-(5-((7-(((1s,3 s)-adamantan-1-yl)amino)heptyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3 (4H)-yl)piperidine-2,6-dione; (S)-3-(5-((7-((4-fluorobicyclo[2.2.2]octan-1-yl)amino)heptyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione; (3S)-3-(5-((7-((2-isopropyl-5-methylcyclohexyl)oxy)heptyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3 (4H)-yl)piperidine-2,6-dione; (S)-3-(4-oxo-2-(trifluoromethyl)-5-((7-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)heptyl)amino)quinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((7-(((1s,3s)-adamantan-1-yl)amino)heptyl)amino)-2-butyl-4-oxoquinazolin-3(4H)-yl) piperidine-2,6-dione; 3-(5-((7-(((1s,3s)-adamantan-1-yl)amino)heptyl)amino)-2-(methyl-d3)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(2-(7-(((3s,5s,7s)-adamantan-1-yl)amino)heptyl)-5-bromo-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(2-(7-(((3 s, 5 s,7s)-adamantan-1-yl)amino)heptyl)-5-fluoro-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 2-(7-(((3s,5s,7s)-adamantan-1-yl)amino)heptyl)-3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydroquinazoline-5-carbonitrile; 3-(2-(3-(3-(((3s,5s,7s)-adamantan-l-yl)(methyl)amino)propoxy)propyl)-5-bromo-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(((1s,3s)-adamantan-1-yl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(4-(3-(((3s,5s,7s)-adamantan-1-yl)amino)propyl)piperazin-1-yl)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(6-(4-(3-(((3s,5s,7s)-adamantan-1-yl)amino)propyl)piperazin-1-yl)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 4-(4-(3-(2,4-dioxocyclohexyl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)piperazin-1-yl)-3-fluorobenzonitrile; 3-(7-(4-(3-(((3s,5s,7s)-adamantan-1-yl)aminoo)propyl)piperazin-1-yl)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(8-(4-(3-(((3s,5s,7s)-adamantan-1-yl)amino)propyl)piperazin-1-yl)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-(((2-((((3 s, 5 s,7s)-adamantan-1-yl)amino)methyl)cyclopropyl); methyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(2-(8-(((3 s, 5 s,7s)-adamantan-1-yl)amino)octyl)-5-fluoro-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3 -(5-((7-(((1s,3 s)-adamantan-1-yl)amino)heptyl)amino)-2-(8-(((3 s, 5 s,7s)-adamantan-1-yl)amino)octyl)-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((2-((2-(((1s,3s)-adamantan-1-yl)amino)ethyl)thio)ethyl)amino)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3 -(5-((5-(((1s,3 s)-adamantan-1-yl)amino)-3-oxopentyl)amino)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((5-(((1s,3s)-adamantan-1-yl)amino)-3,3-difluoropentyl)amino)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((5-(((1s,3s)-adamantan-1-yl)amino)-3-thioxopentyl)amino)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 2-(((3s,5s,7s)-adamantan-1-yl)amino)ethyl 3-((3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)amino)propanoate; N-(4-(((3s,5s,7s)-adamantan-1-yl)(methyl)amino)butyl)-3-((3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)amino)propanamide; 3-(5-((2-((2-(((1s,3 s)-adamantan-1-yl)amino)ethyl)amino)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-((2-(((1s,3 s)-adamantan-1-yl)amino)ethyl)(methyl)amino)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((7-hydroxyheptyl)oxy)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((7-(((1s,3s)-adamantan-1-yl)amino)heptyl)oxy)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(2-methyl-5-((7-(4-(oxetan-3-yl)piperazin-1-yl)heptyl)oxy)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(2-methyl-5-((7-(4-methylpiperazin-1-yl)heptyl)oxy)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((7-((1-((3r,5r,7r)-adamantan-l-yl)ethyl)amino)heptyl)oxy)-4-oxo-2-(trifluoromethyl)quinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((7-(((3as,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)heptyl)oxy)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((7-(((1s,3s)-adamantan-1-yl)amino)heptyl)oxy)-4-oxo-2-(trifluoromethyl)quinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(4-oxo-2-(trifluoromethyl)-5-((7-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)heptyl)oxy)quinazolin-3(4H)-yl)piperidine-2,6-dione; (S)-3-(2-methyl-4-oxo-5-((7-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)heptyl)oxy)quinazolin-3(4H)-yl)piperidine-2,6-dione; (S)-3-(5-((7-((4-fluorobicyclo[2.2.2]octan-1-yl)amino)heptyl)oxy)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; (3R)-3-(5-((7-(((1s,3s)-adamantan-1-yl)amino)heptyl)oxy)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; (R)-3-(5-(2-(2-(2-(((3s,5s,7s)-adamantan-1-yl)amino)ethoxy)ethoxy)ethoxy)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; (S)-3-(5-((7-(((1 SR,3RS,SSR,7r)-3,5-dimethyladamantan-1-yl)amino)heptyl)oxy)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; (S)-3-(5-((7-(((1 SR,3RS,SSR,7r)-3,5-dimethyladamantan-1-yl)amino)heptyl)oxy)-4-oxo-2-(trifluoromethyl)quinazolin-3 (4H)-yl)piperidine-2,6-dione; (3 S)-3-(5-((7-((1-((3r,5r,7r)-adamantan-1-yl)ethyl)amino)heptyl)oxy)-4-oxo-2-(trifluoromethyl)quinazolin-3 (4H)-yl)piperidine-2,6-dione; (3R)-3-(5-((7-(((3as,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)heptyl)oxy)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione; (3R)-3-(5-((7-(((1s,3s)-adamantan-1-yl)amino)heptyl)oxy)-4-oxo-2-(trifluoromethyl)quinazolin-3 (4H)-yl)piperidine-2,6-dione; (S)-3-(4-oxo-2-(trifluoromethyl)-5-((7-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)heptyl)oxy)quinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((7-(((1s,3s)-adamantan-1-yl)amino)heptyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((7-(((1 SR,3RS, 5 SR,7r)-3, 5-dimethyladamantan-1-yl)amino)heptyl)thio)-4-oxo-2-(trifluoromethyl)quinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((7-(((1s,3s)-adamantan-1-yl)amino)heptyl)thio)-4-oxo-2-(trifluoromethyl)quinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(4-oxo-2-(trifluoromethyl)-5-((7-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)heptyl)thio)quinazolin-3 (4H)-yl)piperidine-2,6-dione; (S)-3-(5-((7-(((1 SR,3RS,SSR,7r)-3,5-dimethyladamantan-1-yl)amino)heptyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; (3 S)-3-(5-((7-((1-((3r,5r,7r)-adamantan-1-yl)ethyl)amino)heptyl)thio)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; (3R)-3-(5-((7-(((1s,3s)-adamantan-1-yl)amino)heptyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; (S)-3-(2-methyl-4-oxo-5-((7-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)heptyl)thio)quinazolin-3 (4H)-yl)piperidine-2,6-dione; (S)-3-(4-oxo-2-(trifluoromethyl)-5-((7-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)heptyl)thio)quinazolin-3 (4H)-yl)piperidine-2,6-dione; (S)-3-(5-((7-((4-fluorobicyclo[2.2.2]octan-1-yl)amino)heptyl)thio)-4-oxo-2-(trifluoromethyl)quinazolin-3 (4H)-yl)piperidine-2,6-dione; (3R)-3-(5-((7-(((1s,3s)-adamantan-1-yl)amino)heptyl)thio)-4-oxo-2-(trifluoromethyl)quinazolin-3 (4H)-yl)piperidine-2,6-dione; (S)-3-(5-((7-(((1 SR,3RS,SSR,7r)-3,5-dimethyladamantan-1-yl)amino)heptyl)thio)-4-oxo-2-(trifluoromethyl)quinazolin-3 (4H)-yl)piperidine-2,6-dione; 3 -(5 -(3 -(((3 s, 5s,7s)-adamantan-1-yl)amino)prop-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-(5-hydroxypent-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3 -(5 -(5 -(((3 s, 5 s,7s)-adamantan-1-yl)amino)pent-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(2-methyl-4-oxo-5-(5-(piperidin-1-yl)pent-1-yn-1-yl)quinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(2-methyl-5-(5-(4-methylpiperazin-1-yl)pent-1-yn-1-yl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3 -(2-methyl-5 -(5 -(4-(oxetan-3-yl)piperazin-1-yl)pent-1-yn-1-yl)-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3 -(2-methyl-5 -(5 -(4-methyl-1,4-diazepan-1-yl)pent-1-yn-1-yl)-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3 -(5 -(5 -(6-oxa-3 -azabicyclo [3 .1.1]heptan-3 -yl)pent-1 -yn-1-yl)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(2-methyl-5-(5-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)pent-1-yn-1-yl)-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3 -(2-methyl-5 -(5 -(4-morpholinopiperidin-1 -yl)pent-1 -yn-1 -yl)-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-(5-((1-((1s,3s)-adamantan-1-yl)ethyl)amino)pent-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-(8-hydroxyoct-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(8-(((1s,3 s)-adamantan-1-yl)amino)oct-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3 -(2-methyl-5 -(8-(4-(oxetan-3 -yl)piperazin-1 -yl)oct-1 -yn-1 -yl)-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(2-methyl-5-(8-(4-methylpiperazin-1-yl)oct-1-yn-1-yl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3 -(2-methyl-5 -(8-(4-(4-methylpiperazin-1 -yl)piperidin-1 -yl)oct-1 -yn-1 -yl)-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3 -(5 -(8-(6-oxa-3 -azabicyclo [3.1.1]heptan-3 -yl)oct-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-(5-hydroxypentyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(5-(((3s,5s,7s)-adamantan-1-yl)amino)pentyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(2-methyl-5-(5-(4-(oxetan-3-yl)piperazin-1-yl)pentyl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(5-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)pentyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(2-methyl-5-(5-(4-methylpiperazin-1-yl)pentyl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(2-methyl-5-(5-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)pentyl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(8-hydroxyoctyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(8-(((1s,3s)-adamantan-1-yl)amino)octyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(2-methyl-5-(8-(4-(oxetan-3-yl)piperazin-1-yl)octyl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(2-methyl-5-(8-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)octyl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(8-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)octyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(2-methyl-5-(8-(4-methylpiperazin-1-yl)octyl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(4-oxo-2-(trifluoromethyl)-5-(8-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)octyl)quinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(4-oxo-2-(trifluoromethyl)-5-(8-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)oct-1-yn-1-yl)quinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-(8-(((1s,3s)-adamantan-l-yl)amino)octyl)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione; 3 -(5-(8-(((1s,3 s)-adamantan-1 -yl)amino)oct-1 -yn-1 -yl)-4-oxo-2-(trifluoromethyl)quinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-(8-((1-((3r,5r,7r)-adamantan-1-yl)ethyl)amino)octyl)-4-oxo-2-(trifluoromethyl)quinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-(8-((1-((3r,5r,7r)-adamantan-1-yl)ethyl)amino)oct-1-yn-1-yl)-4-oxo-2-(trifluoromethyl)quinazolin-3 (4H)-yl)piperidine-2,6-dione; (S)-3-(2-methyl-4-oxo-5-(8-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)octyl)quinazolin-3(4H)-yl)piperidine-2,6-dione; (S)-3-(2-methyl-4-oxo-5-(8-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)oct-1-yn-1-yl)quinazolin-3 (4H)-yl)piperidine-2,6-dione; (3R)-3-(5-(8-(((1s,3s)-adamantan-1-yl)amino)octyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; (3R)-3-(5-(8-(((1s,3s)-adamantan-1-yl)amino)oct-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; (3R)-3-(5-(8-(((3as,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)octyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; (3R)-3-(5-(8-(((3 as,6as)-hexahydro-2, 5-methanopentalen-3 a(1H)-yl)amino)oct-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; (3S)-3-(5-(8-((1-((3r,5r,7r)-adamantan-1-yl)ethyl)amino)octyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; (3S)-3-(5-(8-((1-((3r,5r,7r)-adamantan-1-yl)ethyl)amino)oct-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; (S)-3-(5-(8-(((1 SR,3RS,SSR,7r)-3,5-dimethyladamantan-1-yl)amino)octyl)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione; (S)-3-(5-(8-(((1 SR,3RS,SSR,7r)-3,5-dimethyladamantan-1-yl)amino)oct-1-yn-1-yl)-4-oxo-2-(trifluoromethyl)quinazolin-3 (4H)-yl)piperidine-2,6-dione; (3 S)-3-(5-(8-((1-((3r,5r,7r)-adamantan-1-yl)ethyl)amino)octyl)-4-oxo-2-(trifluoromethyl)quinazolin-3 (4H)-yl)piperidine-2,6-dione; (3S)-3-(5-(8-((1-((3r,5r,7r)-adamantan-1-yl)ethyl)amino)oct-1-yn-1-yl)-4-oxo-2-(trifluoromethyl)quinazolin-3 (4H)-yl)piperidine-2,6-dione; (3R)-3-(5-(8-(((1s,3s)-adamantan-1-yl)amino)octyl)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione; (3R)-3 -(5-(8-(((1s,3 s)-adamantan-1-yl)amino)oct-1-yn-1-yl)-4-oxo-2-(trifluoromethyl)quinazolin-3 (4H)-yl)piperidine-2,6-dione; (3S)-3-(5-(8-((2-isopropyl-5-methylcyclohexyl)oxy)octyl)-4-oxo-2-(trifluoromethyl)quinazolin-3 (4H)-yl)piperidine-2,6-dione; (3S)-3-(5-(8-((2-isopropyl-5-methylcyclohexyl)oxy)oct-1-yn-1-yl)-4-oxo-2-(trifluoromethyl)quinazolin-3 (4H)-yl)piperidine-2,6-dione; (S)-3-(4-oxo-2-(trifluoromethyl)-5-(8-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)octyl)quinazolin-3(4H)-yl)piperidine-2,6-dione; (S)-3-(4-oxo-2-(trifluoromethyl)-5-(8-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)oct-1-yn-1-yl)quinazolin-3 (4H)-yl)piperidine-2,6-dione; 3 -(6-(3-(((1s,3 s)-adamantan-1-yl)amino)prop-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(6-(3-(((1s,3s)-adamantan-1-yl)amino)propyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3 -(6-(5-(((1s,3 s)-adamantan-1-yl)amino)pent-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(6-(5-(((1s,3s)-adamantan-1-yl)amino)pentyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3 -(6-(8-(((3 s, 5s,7s)-adamantan-1-yl)amino)oct-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(6-(8-(((3s,5s,7s)-adamantan-1-yl)amino)octyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(6-(8-((1-((1s,3s)-adamantan-1 -yl)ethyl)amino)oct-1 -yn-1 -yl)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(6-(8-((1 -((1s,3s)-adamantan-1-yl)ethyl)amino)octyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3 -(7-(8-(((3 s, 5 s, 7s)-adamantan-1-yl) amino)oct-1-yn-1-yl)-2-methyl-4-oxo quinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(7-(8-(((3s,5s,7s)-adamantan-1-yl)amino)octyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(7-(8-(((3s,5s,7s)-adamantan-1-yl)amino)octyl)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione; 3 -(8-(8-(((3 s, 5 s, 7s)-adamantan-1-yl) amino)oct-1-yn-1-yl)-2-methyl-4-oxo quinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(8-(8-(((3s,5s,7s)-adamantan-1-yl)amino)octyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3 -(8-(8-(((3 s, 5 s,7s)-adamantan-1-yl)amino)octyl)-4-oxo-2-(trifluoromethyl)quinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-(8-(((1s,3s)-adamantan-1-yl)amino)octyl)-2-(8-(((3s,5s,7s)-adamantan-1-yl)amino)octyl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; (3r,5r,7r)-N-(5-((3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)amino)pentyl)adamantane-1-carboxamide; N-((1s,3 s)-adamantan-1-yl)-7-((3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)amino)heptanamide; 3 -(5-((4-((((1s,3s)-adamantan-1-yl)amino)methyl)piperazin- 1 -yl)methyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((4-(2-(((3 s, 5 s,7s)-adamantan-1-yl)amino)ethyl)piperazin-1-yl)methyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((4-(3-(((1s,3s)-adamantan-1-yl)amino)propyl)piperazin-1-yl)methyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(2-(4-((((3s,5s,7s)-adamantan-1-yl)amino)methyl)piperazin-1-yl)ethyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(2-(4-(2-(((1s,3s)-adamantan-1-yl)amino)ethyl)piperazin-1-yl)ethyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(2-(4-(3-(((3s,5s,7s)-adamantan-1-yl)amino)propyl)piperazin-1-yl)ethyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(3-(4-((((1s,3s)-adamantan-1-yl)amino)methyl)piperazin-1-yl)propyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(3-(4-(2-(((3 s, 5 s,7s)-adamantan-1-yl)amino)ethyl)piperazin-1-yl)propyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(3-(4-(3-(((1s,3s)-adamantan-1-yl)amino)propyl)piperazin-1-yl)propyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((4-(((3r,5r,7r)-adamantan-1-yl)methyl)piperazin-1-yl)methyl)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(2-methyl-4-oxo-5-(piperazin-1-ylmethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(2-methyl-4-oxo-5-(3-(piperazin-1-yl)prop-1-yn-1-yl)quinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((4-(7-(((1s,3s)-adamantan-1-yl)amino)heptyl)piperazin-1-yl)methyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(3-(4-(2-(((3s,5s,7s)-adamantan-1-yl)amino)ethyl)piperazin-1-yl)prop-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(3-(4-(3-(((1s,3s)-adamantan-1-yl)amino)propyl)piperazin-1-yl)prop-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3 -(5 -((2-(4-((1s,3s)-adamantan-1-yl)piperazin-1-yl)ethyl)thio)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((3-(4-((3s,5s,7s)-adamantan-1-yl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-((1s,3s)-adamantan-1 -yl)piperazin-1 -yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-(2-(4-((1s,3s)-adamantan-1-yl)piperazin-1-yl)ethoxy)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-(3-(4-((1s,3s)-adamantan-1 -yl)piperazin-1 -yl)prop-1 -yn-1 -yl)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3 -(5 -(3 -(4-((1s,3s)-adamantan-1-yl)piperazin-1-yl)propyl)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-(((3r,5r,7r)-adamantan-1-yl)methyl)piperazin-1-yl)ethyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3 -(5 -((3-(4-(((1s,3 s)-adamantan-1 -yl)methyl)piperazin-1 -yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-(((3r,5r,7r)-adamantan-1-yl)methyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(2-(4-(((3r,5r,7r)-adamantan-1-yl)methyl)piperazin-1-yl)ethoxy)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-(3-(4-(((3r,5r,7r)-adamantan-1-yl)methyl)piperazin-1-yl)prop-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(3-(4-(((3r,5r,7r)-adamantan-1-yl)methyl)piperazin-1-yl)propyl)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)ethyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(2-(4-(2-((3r,5r,7r)-adamantan-l-yl)ethyl)piperazin-l-yl)ethoxy)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-(3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)prop-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)propyl)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((4-(4-((3r,5r,7r)-adamantan-1-yl)benzyl)piperazin-1-yl)methyl)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((4-(2-((1s,3s)-adamantan-1-yl)ethyl)piperazin-1-yl)methyl)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-(3-(4-(4-((3r,5r,7r)-adamantan-1-yl)benzyl)piperazin-1-yl)prop-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(3-(4-(4-((3r,5r,7r)-adamantan-1-yl)benzyl)piperazin-1-yl)propyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-((1s,3 s)-adamantan-1-yl)piperazin-1-yl-2,2,3,3, 5, 5,6,6-d8)ethyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-((1s,3s)-adamantan-1-yl)piperazin-1-yl-2,2,3,3,5,5,6,6-d8)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(2-(4-((1s,3s)-adamantan-1-yl)piperazin-1-yl-2,2,3,3,5,5,6,6-d8)ethoxy)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(3-(4-(((3r,5r,7r)-adamantan-1-yl)methyl)piperazin-1-yl-2,2,3,3,5,5,6,6-d8)prop-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-(3-(4-(2-((1s,3s)-adamantan-1-yl)ethyl)piperazin-1-yl-2,2,3,3,5,5,6,6-d8)prop-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(3-(4-(2-((1s,3s)-adamantan-1-yl)ethyl)piperazin-1-yl-2,2,3,3,5,5,6,6-d8)propyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(((1-((((1s,3s)-adamantan-1-yl)amino)methyl)cyclopropyl)methyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((4-(2-(((2R,3as,5S,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)ethyl)piperazin-1-yl)methyl)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((4-(3-(((3as,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)propyl)piperazin-1-yl)methyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-((2-(((1s,3s)-adamantan-1-yl)amino)ethyl)(methyl)amino)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; N-((3 s, 5 s,7s)-adamantan-1-yl)-2-((3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)amino)ethane-1-sulfonamide; N-((1s,3 s)-adamantan- 1-yl)-1-(1 -(3 -(2,6-dioxopiperidin-3 -yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)piperidin-3-yl)methanesulfonamide; N-((3 s, 5 s,7s)-adamantan-1-yl)-2-((3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)thio)ethane- 1 -sulfonamide; N-((3 s, 5 s,7s)-adamantan-1-yl)-2-((3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)oxy)ethane- 1 -sulfonamide; N-((3s,5s,7s)-adamantan-1-yl)-3-(3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)propane-1-sulfonamide; N-((3s,5s,7s)-adamantan-1-yl)-3-((3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)amino)propane-1-sulfonamide; 3-(2-methyl-5-((4-((4-(oxetan-3-yl)piperazin-1-yl)sulfonyl)butyl)amino)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((3-(4-(((3 s, 5 s,7s)-adamantan-1-yl)amino)-1H-1,2,3-triazol-1-yl)propyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(8-((2-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)ethyl)amino)-3-methyl-1-oxoisoquinolin-2(1H)-yl)piperidine-2,6-dione; 3-(5-((3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3 -(5 -((3 -(4-benzhydrylpiperazin-1 -yl)propyl)thio)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((3-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((3-(4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(6-((3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(7-((3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(8-((3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(6-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(7-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(8-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(3-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,6-diazabicyclo[3.1.1]heptan-6-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(6-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(3-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(8-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(5-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((1S,4S)-5-(2-((3S,5S,7S)-adamantan-1-yl)ethyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((1R,4R)-5-(2-((3R,5R,7R)-adamantan-1-yl)ethyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,5-dimethylpiperazin-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2,6-dimethylpiperazin-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2-(trifluoromethyl)piperazin-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2-(fluoromethyl)piperazin-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2,2-dimethylpiperazin-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-1,4-diazepan-1-yl)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,5-dimethylpiperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2,6-dimethylpiperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2-(trifluoromethyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2-(fluoromethyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2,2-dimethylpiperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-1,4-diazepan-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(3-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,6-diazabicyclo[3.1.1]heptan-6-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(6-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(3-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((2-(8-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((2-(5-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((2-((1S,4S)-5-(2-((3S,5S,7S)-adamantan-1-yl)ethyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-((1R,4R)-5-(2-((3R,5R,7R)-adamantan-1-yl)ethyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,5-dimethylpiperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2,6-dimethylpiperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3-(trifluoromethyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2-(fluoromethyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2,2-dimethylpiperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-1,4-diazepan-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-benzhydrylpiperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-((4'-fluoro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-((4'-fluoro-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-((4'-chloro-4-methoxy-4-methyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-((4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-((4-(4-chlorophenyl)-5,6-dihydro-2H-pyran-3-yl)methyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-((4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-pyran-3-yl)methyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-((4'-chloro-4,4-difluoro-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-((8-(4-chlorophenyl)spiro[4.5]dec-7-en-7-yl)methyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-((6-(4-chlorophenyl)spiro[3.5]non-6-en-7-yl)methyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((3-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((3-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((3-(4-((4'-fluoro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((3-(4-((4'-fluoro-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((3-(4-((4'-chloro-4-methoxy-4-methyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((3-(4-((4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((3-(4-((4-(4-chlorophenyl)-5,6-dihydro-2H-pyran-3-yl)methyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((3-(4-((4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-pyran-3-yl)methyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((3-(4-((4'-chloro-4,4-difluoro-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((3-(4-((8-(4-chlorophenyl)spiro[4.5]dec-7-en-7-yl)methyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((3-(4-((6-(4-chlorophenyl)spiro[3.5]non-6-en-7-yl)methyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 4-(4-(2-((3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)thio)ethyl)piperazin-1-yl)-3-fluorobenzonitrile; 3-(5-((2-(4-(4-((1s,3s)-adamantan-1-yl)benzyl)piperazin-1-yl)ethyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-(((1s,3s)-adamantan-1-yl)methyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-(4-((1s,3s)-adamantan-1-yl)benzyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 4-(4-(2-((3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)amino)ethyl)piperazin-1-yl)-3 -fluorobenzonitrile; 3-(5-(2-(4-((3s,5s,7s)-adamantan-1-yl)piperazin-1-yl)ethoxy)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(2-(4-(4-((1s,3s)-adamantan-1-yl)benzyl)piperazin-1-yl)ethoxy)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 4-(4-(2-((3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)oxy)ethyl)piperazin-1 -yl)-3 -fluorobenzonitrile; 3-(5-((4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)methyl)-2-methyl-4-oxoquinazolin-3 (4H)-yl)piperidine-2,6-dione; 3-(5-((4-((1s,3 s)-adamantane-1-carbonyl)piperazin-1-yl)methyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(3-(4-(2-((1s,3s)-adamantan-1-yl)ethyl)piperazin-1-yl)prop-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; or 3-(5-(3-(4-((3r,5r,7r)-adamantane-1-carbonyl)piperazin-1-yl)prop-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione.

37. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in any one of claims 1-36, which is hydrochlorides, sulfates, citrates, maleates, sulfonates, citrates, lactates, tartrates, fumarates, phosphates, dihydrophosphates, pyrophosphates, metaphosphates, oxalates, malonates, benzoates, mandelates, succinates, trifluoroacetates, hydroxyacetates, or p-toluenesulfonates of the compound of Formula (I).

38. A pharmaceutical composition comprising the compound of Formula (I) or pharmaceutically acceptable salts thereof as claimed in any one of claims 1-37, and at least one pharmaceutically acceptable carrier, and optionally further comprising at least one additional therapeutic agent, e.g., an anticancer agent.

39. Use of the compound of Formula (I) or pharmaceutically acceptable salts thereof as claimed in any one of claims 1-37, or the pharmaceutical composition as claimed in claim 38 for the manufacture of a medicament for the prevention and / or treatment of diseases or disorders associated with cereblon protein; preferably, wherein the diseases or disorders associated with cereblon protein are selected from the group consisting of: tumor, infectious disease, inflammatory disease, autoimmune disease, anemia, hemorrhagic shock, transplant rejection, multiple organ dysfunction syndrome (MODS), sarcoidosis, adult respiratory distress syndrome, cardiovascular disease, Richter syndrome (RS), acute liver failure, or diabetes; more preferably, wherein the diseases or disorders associated with cereblon protein are selected from the group consisting of: myeloma, including multiple myeloma, plasma cell myeloma, smoldering myeloma, smoldering multiple myeloma; myelofibrosis; bone marrow disease; myelodysplastic syndrome (MDS); previously treated myelodysplastic syndrome; transplantation-related cancer; neutropenia; leukemia, including acute myeloid leukemia, chronic myelogenous leukemia, B-cell chronic lymphocytic leukemia, leukemia-associated anemia, acute myeloid leukemia (AML); lymphoma, including diffuse large B-cell lymphoma, non-Hodgkin's lymphoma, Hodgkin's lymphoma, anaplastic lymphoma, anaplastic large cell lymphoma, CD20 positive lymphoma, mantle cell lymphoma, primary lymphoma, B-cell lymphoma, recurrent B-cell non-Hodgkin's lymphoma, recurrent diffuse large B-cell lymphoma, recurrent mediastinal (thymic) large B-cell lymphoma, primary mediastinal (thymic) large B-cell lymphoma, recurrent transformed non-Hodgkin's lymphoma, refractory B-cell non-Hodgkin's lymphoma, refractory diffuse large B-cell lymphoma, refractory primary mediastinal (thymic) large B-cell lymphoma, refractory transformed non-Hodgkin's lymphoma; thyroid cancer; melanoma; lung cancer, including lung adenocarcinoma, lung squamous cell carcinoma; inflammatory myofibroblastoma; colorectal cancer; intestinal cancer; brain glioma; astroblastoma; ovarian cancer; bronchial cancer; prostate cancer; breast cancer, including triple negative breast cancer, sporadic breast cancer and patients with Cowden syndrome; pancreatic cancer; central nervous system tumor; neuroblastoma; neuroglioma; Peripheral neuroepithelioma; extramedullary plasmacytoma; plasmacytoma; gastric cancer; gastrointestinal stromal tumors; esophageal cancer; colorectal adenocarcinoma; esophageal squamous cell carcinoma; liver cancer; renal cell carcinoma; bladder cancer; endometrial cancer; metrocarcinoma; head and neck cancer; brain cancer; oral cancer; sarcoma, including rhabdomyosarcoma, various lipogenic tumors, Ewing's sarcoma / primitive neuroectodermal tumors (Ewing / PNETs), and leiomyosarcoma; urothelial carcinoma; basal cell carcinoma; oral squamous cell carcinoma; cholangiocarcinoma; bone cancer; cervical cancer; skin cancer; Richter syndrome (RS); sepsis syndrome; autoimmune diseases, including rheumatoid arthritis, autoimmune encephalomyelitis, ankylosing spondylitis, psoriasis, systemic lupus erythematosus, multiple sclerosis, recurrent oral ulcers, Kawasaki disease, polymyositis / dermatomyositis, Sjogren's syndrome, and atopic dermatitis; keratoconjunctivitis; inflammatory diseases, including Crohn's disease and ulcerative colitis, pneumonia, osteoarthritis, synovitis, systemic inflammatory response syndrome, airway inflammation, bronchitis; cerebral malaria; infectious diseases, including viral pneumonia, Acquired immunodeficiency syndrome (AIDS), COVID-19 novel coronavirus infection, gram-negative bacteria infection, gram-positive bacteria infection, tuberculosis, etc.; septic shock; tuberculosis; bacterial meningitis; chronic obstructive pulmonary disease; asthma; hemorrhagic shock; organ (including kidney, heart, lung) or tissue transplantation rejection; diabetes; sarcoidosis; adult respiratory distress syndrome; anemia; pediatric aplastic anemia; cardiovascular diseases (e.g., coronary heart disease, congestive heart failure, myocardial infarction, atherosclerosis); multiple organ dysfunction caused by cachexia and septic shock; or acute liver failure.

40. The compound of Formula (I) or pharmaceutically acceptable salts thereof as claimed in any one of claims 1-37, for use in the prevention and / or treatment of diseases or disorders associated with cereblon protein; preferably, wherein the diseases or disorders associated with cereblon protein are selected from the group consisting of: tumor, infectious disease, inflammatory disease, autoimmune disease, anemia, hemorrhagic shock, transplant rejection, multiple organ dysfunction syndrome (MODS), sarcoidosis, adult respiratory distress syndrome, cardiovascular disease, Richter syndrome (RS), acute liver failure, or diabetes; more preferably, wherein diseases or disorders associated with cereblon protein are selected from the group consisting of: myeloma, including multiple myeloma, plasma cell myeloma, smoldering myeloma, smoldering multiple myeloma; myelofibrosis; bone marrow disease; myelodysplastic syndrome (MDS); previously treated myelodysplastic syndrome; transplantation-related cancer; neutropenia; leukemia, including acute myeloid leukemia, chronic myelogenous leukemia, B-cell chronic lymphocytic leukemia, leukemia-associated anemia, acute myeloid leukemia (AML); lymphoma, including diffuse large B-cell lymphoma, non-Hodgkin's lymphoma, Hodgkin's lymphoma, anaplastic lymphoma, anaplastic large cell lymphoma, CD20 positive lymphoma, mantle cell lymphoma, primary lymphoma, B-cell lymphoma, recurrent B-cell non-Hodgkin's lymphoma, recurrent diffuse large B-cell lymphoma, recurrent mediastinal (thymic) large B-cell lymphoma, primary mediastinal (thymic) large B-cell lymphoma, recurrent transformed non-Hodgkin's lymphoma, refractory B-cell non-Hodgkin's lymphoma, refractory diffuse large B-cell lymphoma, refractory primary mediastinal (thymic) large B-cell lymphoma, refractory transformed non-Hodgkin's lymphoma; thyroid cancer; melanoma; lung cancer, including lung adenocarcinoma, lung squamous cell carcinoma; inflammatory myofibroblastoma; colorectal cancer; intestinal cancer; brain glioma; astroblastoma; ovarian cancer; bronchial cancer; prostate cancer; breast cancer, including triple negative breast cancer, sporadic breast cancer and patients with Cowden syndrome; pancreatic cancer; central nervous system tumor; neuroblastoma; neuroglioma; Peripheral neuroepithelioma; extramedullary plasmacytoma; plasmacytoma; gastric cancer; gastrointestinal stromal tumors; esophageal cancer; colorectal adenocarcinoma; esophageal squamous cell carcinoma; liver cancer; renal cell carcinoma; bladder cancer; endometrial cancer; metrocarcinoma; head and neck cancer; brain cancer; oral cancer; sarcoma, including rhabdomyosarcoma, various lipogenic tumors, Ewing's sarcoma / primitive neuroectodermal tumors (Ewing / PNETs), and leiomyosarcoma; urothelial carcinoma; basal cell carcinoma; oral squamous cell carcinoma; cholangiocarcinoma; bone cancer; cervical cancer; skin cancer; Richter syndrome (RS); sepsis syndrome; autoimmune diseases, including rheumatoid arthritis, autoimmune encephalomyelitis, ankylosing spondylitis, psoriasis, systemic lupus erythematosus, multiple sclerosis, recurrent oral ulcers, Kawasaki disease, polymyositis / dermatomyositis, Sjogren's syndrome, and atopic dermatitis; keratoconjunctivitis; inflammatory diseases, including Crohn's disease and ulcerative colitis, pneumonia, osteoarthritis, synovitis, systemic inflammatory response syndrome, airway inflammation, bronchitis; cerebral malaria; infectious diseases, including viral pneumonia, Acquired immunodeficiency syndrome (AIDS), COVID-19 novel coronavirus infection, gram-negative bacteria infection, gram-positive bacteria infection, tuberculosis, etc.; septic shock; tuberculosis; bacterial meningitis; chronic obstructive pulmonary disease; asthma; hemorrhagic shock; organ (including kidney, heart, lung) or tissue transplantation rejection; diabetes; sarcoidosis; adult respiratory distress syndrome; anemia; pediatric aplastic anemia; cardiovascular diseases (e.g., coronary heart disease, congestive heart failure, myocardial infarction, atherosclerosis); multiple organ dysfunction caused by cachexia and septic shock; or acute liver failure.

41. A method for treating or preventing diseases or disorders associated with cereblon protein in a subject, comprising administering to the subject a therapeutically effective amount of the compound of Formula (I) or pharmaceutically acceptable salts thereof as claimed in any one of claims 1-37, or the pharmaceutical composition as claimed in claim 38; preferably, wherein the diseases or disorders associated with cereblon protein are selected from the group consisting of: tumor, infectious disease, inflammatory disease, autoimmune disease, anemia, hemorrhagic shock, transplant rejection, multiple organ dysfunction syndrome (MODS), sarcoidosis, adult respiratory distress syndrome, cardiovascular disease, Richter syndrome (RS), acute liver failure, or diabetes; more preferably, wherein diseases or disorders associated with cereblon protein are selected from the group consisting of: myeloma, including multiple myeloma, plasma cell myeloma, smoldering myeloma, smoldering multiple myeloma; myelofibrosis; bone marrow disease; myelodysplastic syndrome (MDS); previously treated myelodysplastic syndrome; transplantation-related cancer; neutropenia; leukemia, including acute myeloid leukemia, chronic myelogenous leukemia, B-cell chronic lymphocytic leukemia, leukemia-associated anemia, acute myeloid leukemia (AML); lymphoma, including diffuse large B-cell lymphoma, non-Hodgkin's lymphoma, Hodgkin's lymphoma, anaplastic lymphoma, anaplastic large cell lymphoma, CD20 positive lymphoma, mantle cell lymphoma, primary lymphoma, B-cell lymphoma, recurrent B-cell non-Hodgkin's lymphoma, recurrent diffuse large B-cell lymphoma, recurrent mediastinal (thymic) large B-cell lymphoma, primary mediastinal (thymic) large B-cell lymphoma, recurrent transformed non-Hodgkin's lymphoma, refractory B-cell non-Hodgkin's lymphoma, refractory diffuse large B-cell lymphoma, refractory primary mediastinal (thymic) large B-cell lymphoma, refractory transformed non-Hodgkin's lymphoma; thyroid cancer; melanoma; lung cancer, including lung adenocarcinoma, lung squamous cell carcinoma; inflammatory myofibroblastoma; colorectal cancer; intestinal cancer; brain glioma; astroblastoma; ovarian cancer; bronchial cancer; prostate cancer; breast cancer, including triple negative breast cancer, sporadic breast cancer and patients with Cowden syndrome; pancreatic cancer; central nervous system tumor; neuroblastoma; neuroglioma; Peripheral neuroepithelioma; extramedullary plasmacytoma; plasmacytoma; gastric cancer; gastrointestinal stromal tumors; esophageal cancer; colorectal adenocarcinoma; esophageal squamous cell carcinoma; liver cancer; renal cell carcinoma; bladder cancer; endometrial cancer; metrocarcinoma; head and neck cancer; brain cancer; oral cancer; sarcoma, including rhabdomyosarcoma, various lipogenic tumors, Ewing's sarcoma / primitive neuroectodermal tumors (Ewing / PNETs), and leiomyosarcoma; urothelial carcinoma; basal cell carcinoma; oral squamous cell carcinoma; cholangiocarcinoma; bone cancer; cervical cancer; skin cancer; Richter syndrome (RS); sepsis syndrome; autoimmune diseases, including rheumatoid arthritis, autoimmune encephalomyelitis, ankylosing spondylitis, psoriasis, systemic lupus erythematosus, multiple sclerosis, recurrent oral ulcers, Kawasaki disease, polymyositis / dermatomyositis, Sjogren's syndrome, and atopic dermatitis; keratoconjunctivitis; inflammatory diseases, including Crohn's disease and ulcerative colitis, pneumonia, osteoarthritis, synovitis, systemic inflammatory response syndrome, airway inflammation, bronchitis; cerebral malaria; infectious diseases, including viral pneumonia, Acquired immunodeficiency syndrome (AIDS), COVID-19 novel coronavirus infection, gram-negative bacteria infection, gram-positive bacteria infection, tuberculosis, etc.; septic shock; tuberculosis; bacterial meningitis; chronic obstructive pulmonary disease; asthma; hemorrhagic shock; organ (including kidney, heart, lung) or tissue transplantation rejection; diabetes; sarcoidosis; adult respiratory distress syndrome; anemia; pediatric aplastic anemia; cardiovascular diseases (e.g., coronary heart disease, congestive heart failure, myocardial infarction, atherosclerosis); multiple organ dysfunction caused by cachexia and septic shock; or acute liver failure.

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