Binding agents targeting trop2-expressing tumor cells

Abstract

The present disclosure generally relates to binding agents, such as antibodies and antigen binding fragments thereof, that are capable of binding to trophoblast cell surface antigen-2 (TROP2). Also disclosed herein are binding agents that are capable of targeting TROP2-expressing tumor cells and their use for the treatment of cancer. Single domain antibodies that specifically binds to amino acid residues of the extracellular domain of TROP2 are provided.

Description

[0001]: - nnreamreesnenssecreoosu,reaen aerrea ca reaesonn aens, suc as anoes an anen .soscoseer ae onnorooas ce surace anen-um en arenn aensa are caae oaren -exressn nosro ce ams anno ace rre usseueosr oeere eaxmraecne oua cranocmera.n oneoma anre anrovoees.a secca oweversono nas ce surace anen- s a memrane-ounroen exresse a snan anoorrmmaao anu o cess-ucees.unconsas meeoaroncnuenrcaconsncunnucn cenraceuarroens. as an e ons w exraceuar an oowe a am xraceuar eermarowacor -eoman, oman conans a csnoe ance-rscranosmmaemn,r aaneroomoanu annee- coomasmca.e -e oman.n suaons o ecenc, an, an a csene-oor exres s roen normassues aearsoe comensae rane osaoen-s oae ee, wa ccancesrsncu renaereoas cance.r anancsre exressen a we .socem anocem,,e enre ac cancerean e a., vere conen o wcsncororaeeren reerence. moexs.resson o ureuao wnasn s soown coan coner oncoenceavorn severan vro ann vvo measass, an an overaecrease survcvearsns aassocae wncreaseumor aressveness, an aracvear rerous o cu-o-rea cancers, man conuaes oesuvo ner c o caanncce ner arser eaavue.een successuaree cnca ano-ru ea ssu ncona anoes. ’save assocaeruoxcn eecs, narroews, oera-aeruec e wencosw, as,n ana eocaaceverssues.ven ose-mn se an- eraeucsoraens wo areoorm searveons, ceurrerens aerreassnes, nee a ao.mrove omomaemrecsea avn c caranan oonus asneso naeusrarosuce anamoes comose ouncona uermans anmer, .eeav c ers-aserman e a., an ersrom cassca a ans o sacers consanomannvoven noes on aew amno acs susuons norma a e canarnuermans e a., u e a., .ese susuons e anen-rn,nraum,eneu or, anssr reerreo ar aes,resen onr nraanmoewoor r.eonsav. moecuar we o aroun a wc maesem amenaeo a e a enancessueeneraon or ra cea caonsa reure eraeuc acaons,e a-raen ucesu,a suc n aese rasoosoeoncer-eaasseeman.owever,or cearance an omzeeraeuc so aso mnmze rena ou meosoncrease eacaceeer e a.,noes,-, . carrerroenusonsaveeen exoe-, seu scuc co anssrucs caanonn,ro-uccosaon, or oer me su emmunoenc orave maesacrcaesse. reons o sneoman anoesaveeen exoe asunocsooeaveecncrce aanse m auvsec orc a anno coes.n some sues,vaen consrucsaveeen sown oeers e a., mareoe monovaenormonra e a., ncen e a. ,rm ea e a., mmons e a., anuer e a., , suc as sonveeoman annone a a se. an, ns anncu. ennn annoraesm aenns anereeno anrenscroasemenersen.ereo mor eresenscosureereoreenera reaeso ann aen comrsn one or sece acnaennnonroomoaanss, c wee sruerna ace aenas one oe one or more anennnomans .ecconrnn a,ene, onr anea ase onne o oese on ren- seen or msocre. onnomans,nsouman umanseases orsorers assocae w exresson or overseuxrer mesasone o useor.reamen o nnno soem eex ermaceoumarenosm,anenn o aen oase rereresseennscosure mae caae o e.., : or :, seeoenere e a. a,mno a,cesao o ,e enre conens o wc arencororaeer ,. e a., n some emomens,e one or more en reerence. comrse a comemenar anennnomans oenn aen can o a eermnn reon , aeav can varae reon or aeav e sn sneeomomanan an aossscoseeren. acv.or exame,e conmoemeesn oareereesremnnnsco resuroenave unue onneaures anoonno aroove wne csene rcoman o e ssorms a o .mno ac resues oe an oer e exraceuaroman amno ac resues o csene amewor reon nerac w a-araoc an rcoman anoeerorm a c aroune asoe ssscoose.eesree unn.uuerrrosnere,s a cmonneor ac a resnue an a sowssocaon rae eermnn reon an oe comemena s oe comemenar aearonerac w amno ac res reermnn reon o no e an sereo ues oe .araonne amno ac seuence o e on re conemae as suc varaon ma no aecnno . n or so mmoeren ansanecnes,nen oneo omr mansereore comrse, aeas amno ac resues. ac resues ore anennnomans ma comrse amno n oe arnnsraamncewor reon amno ac resues. ac resues anrameesw,ore o reneo onr more an amennon acn resomuaens ma comrse amno amno ac s an oona anor ann aurer re esmuoes.men,e one or more anennnomans ma comrse , ,ne, au arm anenro e amco res ammeune no,s. ace o rene or more anennnomans ma comrseoosen o so am sen emeoommaenn asn,oesc,su osee,es. ren. an amno ac resues correson numernn ac sccoermaencee. w.,aea,resemnmunsoc.o,sure,e s maeene usneaa o.u :- oa,es ,o eranc,e.r-na.,ve: e,mme- uns ma.eene usne numern scemee.., ,n somensances,oeos,,,-, an.or corresonoeaa , ,n oer an annso oarnces,.e , , anor corresonoe , resuesn o so vmarea emr e roemoe.n,e one or more anennnomans ma comrse amno ac co or exame,nn s.ome emomens,e one or more anennnomans ma momrer anse aenn amnnon acom seanuse mncae o c a came or .n oer emomens,e one or emomens,e one or more aneonmnrsen an aommanons a mca seuence o a mouse.ne oer uman.n aurer emomen,e one or more anen comnrnse anom amannso m aca c seuence o amno ac seuence oumanze or e.. omrse an umanze , aumanze came or , or a n s mouse. a are caoamee onsanncuecs,ne anresoen-esceosure reaeso an- sneoman anoes eenen ceuaraocoss .noerneo cveer,uanr o ceoroxnscances,er aensenor ano- reaeso an- sneoman anoesa are scosure amenaeoeverru caae onernazaon manem oernsances,eresenaoascsosnuroe reeumor mcroenvronmen ornoumor ces.nenerereoc unco aeso an- sneoman anoesa wen unconouua,e,nenr aeseennn.s oscoseurere asesno encscomosuarsese msa conauvea aconv o ananns aumenors ces eraeuc moe.onuaon maearcuareneca w wow acv aansumor ces. ennn aensave no or anoccaorsn caa,ee orrensennscosur.e reeareesseno ansc uonscuorneu asaenae sneoman conuae comrsn a sneoman ano o reaeso an anoru ruaoa as caae ornn an a can varae. en renonu.ncosn un o suss conerre a sneoee can name,eeav ss or s ane eroerrovesormanex .or exame, mue muvaence anor mnunsenccom.anns a maoen,u msueneo ao sneeoe ceans mea cane c aossneerrnoncreaseeversmu-araocnn or av oneracon me oreover,e ss anennnomans maeuseo ane oos w .ncunor exame an woumaon,uson w aeav ca ee can nave ano or anennnramenereo, wr n anor can o a mouan oen scao, wmmune ce erenus s au acen so, a moen rerese eenne. erascoosuren non on aen resaesao come srnsee oneom oran anoesscose omans oe sneoman anoesscoseeren more anennn oman ann aooens, oeererseesnenscscosousruere r.eaoers exoamn. e,n aensa comee we sne w one o more sneoman ano sneoman anoesa comee comrsn amno esscoseerenorenn o aeas one eoe enn ac ae resues oe exraceuaroman o arerove. varous n, or anennnomans oenn aen ma comerom cames s,ou srcaers,nrcaunsnencro amnm anams,arso cma sacre oroucn sneoman anoes suc as anoes mae oaneromroma aeeenrnmm oun azna aonn oo roenrasrm eocu.se,o rra esx eamc. oer, aromare arn mammas suc as cames.n some emomens,e anma maemmunze w varaen re accoonren s.a.ncaec weave creasenn varscaoseur ree,oensn man aee onn m saame co omr sreseawoeav can cans.n somensancesewoeav can varae raeoee aowneormaon o amer. reon areneomerzaonoman o-ermn snoamea esmoon, ame anns a,neennnnn aenom coamn ors aes aoee can comrsnn a- ner an c amerzaonoman sneoman ano, oona ao-ermn snoamea esmoon, ame ansm,ere. zanonno ameann c,omrses aoee can comrsnn a- oman o a sneoman ano oona aner an c an anennno-ermn onaera esmoon, ame anns a,neenn. nnn aenom caomn ors aes aoee can comrsnn a- mernza aonoman, an on sneoman ano, aner, c a oma e or more o aner an e an anennnoman o a sne o e arenn soemo reen e. .mno sommee enms,oem anense,ne annoman o a ane anennnoman nom soamne o e aree same.n some emomenns,enennenr oom aann oe a anner oe an areene snamne. ormuan em ,eo or om muee arn esm, ,ooe rmmn ueaners o,a ae an nnormne ua aneenr o , moa ar rmuaeveeereonrm.a seornormua, orormua scoseeren a,ormua,ormua,ormua amno acn a scecourenancece or w moeeessrems. aen moscosure,enn aen ma comrse aona or exame,n accorance weresenecusceos,suaree,se annen aee an a mn- anor-ermnus. anennnomans o sneoman anoe a comrse aona anennnomans mae s s a an- or-ermnus.e aona ma comn arcsceo ar saencueen wce as seeroerseenara erese nc.orso num arec,e core corenn on aee onr m oorre anneenrs.nnoman oman ma comrse ance weresenscosure,e sne n some emo am seenuse,ncee asn seoreren. omans n aen or aeas one oe one or more anennn var comrsee , , , or comnaonereo oeeav can :ae,oman seo:r,n an one o:, s::,:,:,:,:, :,:, :,:,:, :,:,:, :,:,:, :,:,:, :,:, :,:,:,:,:,:,:,:,:,: :, :, :, :, :, :, , :, :, :, :, : :, :, :, :, :, or , omansn a sreom cae eameo omennsn,eounmann aroeno ora as ceeas s ounrea oce ane oneen o-r m:oure a.nennn comrse an amno ac seuence aeas enca, aeas enmcaan an enccaa, aeas enca, ae , aeas en as enca, aeas enca, aeas s:, aeas enca orencaoe amno ac seuence seorn an one o :,:,:,:,:,:,:,:,: :, :, :, :, :, :, , :, :, :, :, : :, :, :, :, :, : , :, :, :, :, , :, :, :, :, :, : :, :, :, :, :, , :, :, :, :, :, :, omans c soo: :, :, nmmer e, sm or e ao vamreanse, ree: onn.n aen or aeas one oe one or more anennn umanze seuences avn a seuence seorerenncun orna or amno ac an comrsnrom oneove amno ac susuons,rom oneove arceuearo enms ororom oneove amno ac aonsereo. exame, a sneomanm anenso oae coremsenrsess ocnoes ourre monrceu anese annnnn aoemna snusc, w aesreonr aeas one oe one or more anennnomansnsorooas ce surace anen a seuea a evn nce c co seam - a nr csoems:emenareermnn reon avne amno ac aovrnne amno ac: s, aeav can comemenareermnn reon :, :,euence seo:rn an aea:, :, eermnn reon av v can comemenar or ne amno ac seuence seorn : a seueaevnce c seanor comnemenar:eer,m anenav re caonn comemenaravneermen amnno re acon :avn ore amno ac: se oruence seor:n an aeav: can, comemen:, eermnn reon avne amno ac seu ar :. ence seorn anennn monre soemcancs e omoemnens oeresenscosuree aeas one oe one or more a aeav can comemenarn aeeenrm orn snn reeooman ano comrses: seuence seorn :, aeav cann comemenaravneermen amnno re ac avne amno ac seuence seorn : on :, :, : an aeav can, comemen:a, eermnn reon avne amno ac seu r or ence seorn : a seueaevnce c seanor comnemenar:eer,m anenav re caonn comemeavne amno ac avne amno ac s nareermnn reon : or :e oruence seor:n an a :, :, eermnn reon eav can comemenar an avne amno ac seuence seorn : a an aemasno ac seenucean,c ae aeaesas enencaca, aeas enca, aeas enca, n :, :, orencaoe amno ac seuence seor :, :, ::,, ::,, ::, :, :, :, , :, :, :, :, :, :, ::,, ::,, :, r se:cc, emomens:,e, aeas one o: :, n oe e, o onre or mo:. oenn aen or sneoman a re anennnomans eermn no comrses aeav can comemenar eav cann c reomonemenareearvmnnne re amonno ac seuencaev sneoern :, a orn : an aeav can co amno ac seuence se avne amno ac seu memenareermnn reon encaoe amno aecnce se seueonrce senorn an o:n an an amno ac seuence aeas or e o :, : omansn oee o:er.arcuar emomens,e aeas one oe one or more anennn eermnn reonnn aen or snavenomea anm anno ao comrses aeav can comemenar eav can comemenareermnn reonc seuencaev sneoer amnno ac seue:nce s,e a oarvnne amno ac: seu aennce a seeaovr cnan comeme:nar an aenermnn reon encaoe amno ac s amno ac seuence aeas :. euence seorn an one o : or omansn o auernernar aceunar o erm snoemoemna,n aen aeas one oe one or more anennn eermnn o comrses aeav can comemenar e reon avne amno ac seuence seorn :, a oravn can comem:enar ane aeremavnn c raeno cnom avne amno ac seuence se avne amno ac seuence seorn eme:nar an aene armmnnon ac re seonuence aeas :e.ncaoe amno ac seuence seorn an one o : or an amnon somensances,e aeas one oe one or more anennnomans comrses n a ecxem seuarenc eem aso semoernn :. werene aeas one oe onse, ore morne ann aenenn on ano omanserecen emomens, seuence as seorn : comrses an amno ac werenn oe aer eexaesm onaer o emeo onmee onrs m,. oree annnen aennn o anom oanse cormecersens a enm amonmoe ans, seuence as seorn c n exemar emomen:. weren s,enn aen o an oerecen emomens, seuence aes s aeeoars onne an oe one or more anennnomans comrses an amno ac n oer exemar e omneo omens,esn:n- ae. werene aeas on n o an oerecen emomens, seuence as seorne an o onee o one or more ans:en-nnomans comrses an amno ac werenn oe aer eexaesm onaer o emeo onmeens,enn aen. o an oerecen emomens, seuence as seor or more anennnomans comrses an amno ac n exem n an one o s:-. werene aeaasr on eme oomee onnse, ore morne ann aenen o an oerecen emomens, seuence a nnomans comrses an amno ac n os seer eoxremna arn e omneo ome s:-. werene aeas one oe one onrs m,oree annnen aennn o anom oanerecen emomens, seuence as seorn s comrses an amno ac n an exemar e anm oonem oen,enns: ae-. scosure maave acvowars cesn ex orr aenssnenunmannomans an oeusreesre on emeorenmeano on a anennsrorccessono. -.n exemar an non-mn nn aens comrsoven :. reore an one n one or more anennnomans caae onno e or more anennnoman caae onno anoro- are ereon e e. snoc .mom , sen eamsse eoommeane ns,re anesen ons onco r a asu neren. ens ann annoram oern an anerennnramen moecue, aroen scao, anmmune eo, an ano-e eresenscosure aso re ce mouan aen oree. or morenn aeso ann aenas caae o comen w one armaceuerca as aecenss ansc eomseoemreenn.s oeresenscosure reaeo a comoson or acceae carr comoson comrsnenn aenscoseeren an aarmaceuca comoseon o coee mrr. arssencs a an con eumaoemennsn o aeenr aessenscossceosuerere reaeo aarmaceuca accea n an aarmaceuca o nucecee c ac oarr seerr en a.scoecns ane emnonm aenens osceosereseenscosure reaeo a nucec ac or se a nucecscoonsae asereecns o anr a e sme oo vmeceonrss o eace cormesernren. snsc ao nsuucree rce aaceo asc veocseor comrsn urer asecs an emomens oeresenscosu eren nn aensc re reaeo a ce exressne n oseeren. exame, a snom aen emoo omre anns, anee cnesn aren enneereo exress ann aen suc asor ccorn,eresenscosure encomassersamsoenaee creeos ora a enx arnesso-e moecue. anennnramenereo or an ano-e an ano or an n oer emomens,e ces are enneer meoeocue. exame, a cmerc anen receor consruc. exccroerssn a,nne areesnen sucsc aossuorer e rencceomorasses- ccoes, ces, monoces or macroaesa exress a cmerc anen onansruc. e nucec ac or asecs an emomens oeresenscosure reaeo a ce comrsn ur e vecorscoseeren. nn aener assceocss an emomens oeresenscosure reaeo a comrsne n some emoemeernesn. nn aenanso a m,ae ma comrse ann aenanso an a or a croae marer.or exame,e ma comrse an ano mna an comenrsne annranm aenen aesreoescrae secerecna.ens moa a.n somensances,e nso a macroae marer, suc a so comrse an anoa nnramen sor exame an woumaons an ano or anen eurer aesreeocs aan enmsoomens oumaenr. e nucec ac or ve esenscosure reaeo a comrsn e cesescuorseer aesc reeo ncrs asncos eemoeremne.ns oeresenscosure reaeo a comrsn reann a ans aoreron oar a.sseeacse an com emrsonm aens,eresenscosure reaeso a meo o armaceuca como mnsernenn aen, comoson or comosnon somseco esmeos emon reennss s,cos ameeeren. n nn aen, comoson orarmaceuca cance sereo a suecavn cancer seecerom eea cancerr,,urneas can ccaenrsuc as sma ceun cancer, non sma ceun cancer, meoma,rosae oasoma, cervccear csaunccer asre neavereas cancer, reca cancer,ancreac cancer, somac cancer, cancer oe, u cronoreca cancer,asrc cancer, ovaran cancer,ro cancer, nec cancer,oo can araer, cancer oe uerus, esoaea cancer,ea an comosnon osersc eomseocer em. reenns,s amensereo an sunec aeanv,n co am meosasaonc c oarncera.rmaceuca amnserenr aseecns onescosure reaeo a meo orean cancer, wc comrses an exressn one or mor aee mnacroscoaseereno a suecavn aumor exressn . e marers suc as,or exame an woumaons, nnn a oener assceocses aner eemnomreannss,ormenres ceens wscos ounree r oera mesoreo a meo o mane nuceec, acscoseere vecors comrsne mo n an oona conuanenn aen w aeraeuc uerecera sceo meo, ae, ocra aroen aown an exenea-e oro nanoarces. rome non-resrcveeaee asncr aovanaes oeresenscosure wecome aaren aseaeescron, wencann evxeenmeraerna emer. soue unersoo,owever, wa o exame on, w reerenceoe accomannorawmennss. oescosure,sven --ures-ur:era,su-sra-neuumroer vo,umxe ov-ermuer oe or m.ceearn reae we , , , o nure ure: r an- ss or w . an- ssosoram- so-wn,n-n o-,, , , or .. an- monocona a x, an ces comare ws s a no as anaze ow comer.eave conro ,urens o:rra o ann v. -voosere ssonsse a suose os o wee.mream,enm o , , m ..n --mane mceumor moe.eav , m an ure:ra on vvo weereamen o e conros. wee ..n --mane mareumor w am, once reamen wa ceumor moe.eave conros.reae mce wserescroenaenu we a aroun aam, an re.ace w , ane neave conro a aose ourem:ra w soewnncae an-umor eec o varousreamen remen wumor mo ereuences..n --mane mce or uer.ee:arvae co snorownse. a eave co an aose o.m ..nn-umor e-ec- o vamrouasnreeamen re mcmeenu wmor moe. uurreros e::ran-. so n vvoarmaconecarameers. reae w a mwn.u.m aor veonumcea oevernmereva osne-re-mane mce s.eave co sence or asence oumanreamen wure:nsroorasm s. ,own c,e va, o or-- c aens-oown ssans coamanrsson w or. un.r aenae- monocona ano.eave conrosncue s ,ure,mae, o - ce or-s. ce ans- ax reso suo.n aeearve cas oreamen w ans onrosncue s u or unreae ces. anccvue u ore: nreae c,soram eso, sown , no e, ce va ecor ce osr o an--- c ses rse.eceanvee conros omarsonsnc , noare ces or s ans . seuences ues cesreae wuman an- anoesenerae we urrom cones - an . mceavneer:en s esecuomrourncroownancrouon wasesen vvon an -- ces s.c.mnsraon o n o arnman weas wna eee wren av-erae-um oor voume reace m3r or u anres--:m. ssorsamsusrannernazaon o , , , aer orours.eave conrousrencue or s a.n.sure n or me-um o-n. ces anu-res: srasnusran-n-erna.znaeornna ozaon wa,s as, , or s w a-sensvero sesse conuaon o ure: e an monore ow comerm.nm. anononno acnan mecrrnoasczoaonm waereesa oe -- ces sown an one reresenave ces sown.e ces were san a, an ours.or eacmeon, nuce were counersane w .maes wenree o wan aen- usunman c- ane mcrosco.c conocauorescence uresae-ar:,n. an- s n o , , , , , or or ces exrsesosnumanure orurearen coam ceares wur ne or ure nse or comaraor mo eave conros a as assess nocona anoes .., -, an orureow: c aanrom -rear.us sranson recnom onanu,man, , , , recomnanuman -r -roens. r ano uruere:ra,usranur ceome,on assasuerrorme w eersa conuae ure an eac o , , , e or, an-ure o sr nnouman re sor orure.:c .roamna anounsersaonr co. emnenon o assuamsane rweensa conuae an ure:rausran comeon ecomnan . an- ssorenn assaseweensae an ure: scemac so ouman recomnan . , , , owrne v aarous consrucs useo maennoman o ure:cure n- ss. an- ss o or wmmunoos..er aonrme w onuman, e,xraceu,aroma onr anu.man cseneooroman .eave conroncues s ans or aunre-s-: scusre osn omemreunnoormoss oer reocrommen wanuman, ,n , near, reuce,ec on-enaurae, ures-os:area us snownasnen. an- ss on recomnan cno o , , , or recomna mousesus roen ure , on ra nroumeannureroe.neaurvee conr, on mouse roenure or on conroncue oncues s ans .osve ures an:-aeusoracnon aa ano. ssouman ano cnnom o , , , or an- suresou:maaneusra wn aa,n a oous, ,., or an- ure-:so n ncae. no c ram sownenn oencae anoes a asncaeesransece w consrucs w varous csene-rcomanruncaons mceu. ureonre:amrae sowneumorrow one xenora moe o.nne w eo aumnor wrow ann- on a ono.es ane m .., onceer wee.reamen soure:ra oe ano- xenora moe o.n. ver meae ceuaraocoss acv o - or unrse o:r an aans --umors. - a sown an exressoneve on --, - an-, anoe-en, c caes measure an soaensn a w anu-o oeen, ca an o an ev ns.aa are sown aso cane ure-e reaveoesoe conro sann. anoes aa:nrsase sown--eose-resuroense, ac-v- o ure an, an s-romea, cuare ces..eesn a assas wereerorme weromea assa uon. noes were serauerom. n w . -- anoes an sowe a eve o acv aans ces. ces, wereas reaveow acv on -- an - corresonunre: verrasonusran ane a aacnsv o- an ane - ces.ssa waserorme a -, --, an ure:rau e ano concenraon o n. ce srane exressoneve on -- an -nenosc aoewrn assanocermowons wer s s.e s an conro s were use an sence encer seecre-esne s a urr neeav-e c:onraros s soa . anoes wneose-resonse acv o an uon no aanse -- ure , an - cesure ureco:wnr.aessnu asnraones weere sera acuerom. n w .uon. corresonn verson, an v o an ane - ces uonnon o e aanse --, --, an waserorm xresson w s s or nos.ssa uree ae ano concenraon o n. xenora moe o:ra-s s-ownnn vvo m ecec.acc oe we- secc anoesne er wee an an w rereae w a m, once ur ere amnsere ae same moar m ..reamen we: aons c soownnes.e-- ces sereonae an macroaes uonrea.men. maecro caeess s soowwee u urereuuaaonon o o awne ure an auearornea omen w aer- anreamen w - an-. ownreuaon o aer uonreamuerne w:arra, sown oreerce anae n o asaocose or macroaes osve aneraceoeosve ces. usrae an oneroo recomnanureroen:sarra uussnra ann ane-nnc o anoes a no ure:ra sowne an-um seconar ano. m .v.n --mane mcor eec o an a aose o ure:ra so eumor moe.eave conros. anoes aa wneose-resonse acv o an .n ces nse --uerane, --meane, an romea, cowerane.e assas wereerorme usneromea assas uare:ra s. uerane, -ow-nme an-eumaonre e,e acn o..no awneranen xenoera-- moes.esn anoes were amnser umor ure:oomcrorae w m .., onceer wee. ano- on-e x xeennoorraa mumooerss coreaecees o wrom sann e , o mouse anoes, macro-a an-es w,..n an oseeve o m.umors were coece ae ae ure:uman coon aenocarc en oe su. orsoe nomaumorssue mcroarra w , romovu csonoroocsca ano.euman mueumorssue mcroarra wasurcase ure :umanrea-snvas avne suacnae c warcnoem aanumoores assuem. , orsoe conro ano.eum mcroarra w wasurc an mueumorssue mcroarra m.aseromovusoocsca - an sane we anoes asoe conurroe:u amnanoea an n secuamuomuosr cess cuaerc mncormoaarr.a weuman mu,eum oorr anssueo mecsr aoarra wasurcaseromovusoocsca - an sane we orsoe cuornem ro:.uma annone.ranesuomnaan c meu carecnuommoar mcroarra w , romovus ssue mcroarra wasurcase ureoo:cs-cra - an sane we anoes a m.ransucen surace renaer cnr.sa seru rceure oe exraceuaroman o roen w roounoman aveoson oesen-coman , ure:-r-, ansen-ooroman arencae. e conac reon ona cocrssa so own one w suracuem oan surace renern sown. eween an occur man narre.e conacs . s anramewor are ne o an anramewor o ure:-ra cocrsa snruccae w arrows. as a ronaram.eece ure o wuman . sece sownnarre. resues on are sown, weneracn resues on umanurew: snow.s amno asc ann roesaeuesnn avcocovreancne weneraco nnumewerenen an ure-: reresensose-resonse nn o . varans onuman recomnanr anumanze no. n w u oen. anoes were sera uerom varans onurueman-: r reecroemseonn nss.ose-resonse nn o anumanze no. n anroen. anoes were sera uerom varans comureas w reo-:a aru .roans. nsusurraene reave uns o umanze romea reore or.n ure as measure we umanzeu vraersans-r a a.:ssa nars.raurse sown ane. renaveur uns o an romea reorer assas. e as measure w e uurerse-,:ose-resuroense, assas cuarrree ou,n -- ces w ure , comareo a.nrurerausr s a ure, ures-:a eonwn ore. renavuere u u.ns o umanze varans reorer re as measure weromea umanzeu vraers assa ans-s. a.:narras sowne reave uns o an romea ure an.n ure as measure w e reons.ure re:orernm asesnas.eween , , , an varae uurree::nnmmeenn o an consen vsaursa snesu seeneces o varans. ure:nmen an co ceorer an acv. ure:nmen onsen vsaursa snesu seeneccese oorer vanrans. ure:nmen o varans seec n acv. ure:nmen o varans eorer acv. ure:nmen o varans s seeeecceeoarsee orn a car aaccevrs.c ooure: cause comeeumor rere s.are sson wonuraon o resonsen ure co:oreca canrecaerm xeenno caruase moumeorn mce. ceun cance rownonne- on-sma urer xe:nora mroeaemen mce. cancer xenor n causeumorrownonnea ea anec urea moen mce. moen m: reamen cause reresson oeoo cooreca cancer xenora no aecce.umreoarmreonw w.e eecoruncon-nu c muan verson o xenora muoreen: mcer.eamen craeuasmeen reres nsoon c oaneeumor-row- oereas cancer xenora moemanen mceecenn aceceorscko. -- umanure reco:manaen oroe vauesnor , , , nno - anure:a ce o n. vauesnor , , nno - ure: enes. -- ae o vauesnor , , acvn ure an-:reame cnes. -- - an w- xen,oran c an nucesumor reressonn an neavesoe conroavn s omarson wosve conro manure: ec oren-esosme . u ae o vauesnor , , , nno - anure reco:mana cen e oroen. nes vauesnor , , nno - --ure an:ae o. c vauesnor , , acvn ure-:reamene ws. , an nucesumor reressonn an ne-av- - an - xenoran comarson wosve conro uereso-e c:onroa avnn secnoren-esosme .o --e: cesn a nouman recomnanroen an ur nmeno oe-av c caens vara.e reons oae anae. enons emomeen ussee oseceaermns "ae" c aonn "eaxn" o ane " cae" an smar reerensne conex oescrn aneura, une ms areoe consrueo coveroe snuar ne ss oerwsencaeeren or cear conrace conex. unersoosose senccucsave an sa ceove orsr oovo “ours” arom conex, as useereneerm “or”s seceeeaeurrmes “ oarn coomr”o wnenerse w use oerensno “eana”e.n as seccscosure o eac oe eerms "comrsn", "avnr w", "nocuuen o",er. oen-eneerms.e an "conann" areoe consrue as “conssn o”so.e, c moenasnn "ncun,u nomeo" uness oerwse noe.eerm s usee rue as cose-ene. e amnor aecn seeueermnc “e.ee”rm re “erso a” encomraosseesn oreou amaonee coromerns an anroenavn aeas en we n eerm “an- an uman roen. roen suc as a ano” reerso an ano o anormaansoe “an- sne en oro aoronereo anncues woumaons asoeeeerm c “anno snma an ane ann a” ro se cear”s. aoe a o mo seeccueca comrses aoecoronsuc oman suc as an anennn ann an anen ora comrses a eerm “ano”s uomanas caae o seccann an anen. or seneroaes sense an encomasses varous ano vmaaens a ann sroucu,r meso,nnocvauenn a annomm,unoseocucn, monocona ano,ocona ano, ano, convenona ano, s ano, mue seccmu-secc ano, nanoo neoman ano, sne can ano,eav can on secc a ,u-en ano,umanze ano, cmerc anoanso a acvnen, an an anennnramena exseesre anennnecnoo.n ano cane naura occurrnnave ore resus or recomnaon are usese n us es. recanereeane. exereesrsmon “ss “nsneeomoamna ann anoo””nc anue “se naavur caan oc ocnurr ann son”e noamuraan an occuorrn or coenasvan c raeno onns r ano as we as sneoman anon wce we as varans suc asumanze or cemaecrec sn aemoemrazanonoman asscoseeren as anoesas amerzaono anoes.en a sneoman “naur man,senera comose owooee cans. came anoaes oc ocrurrn s sanr.eo “maaunr aano occ”urrncues anoesrouce cames encomass anoesa arerouceransenc annm sans meoomeano e axnreosseaevs” aso on anoes.xemar emomens oransenc a can acaono. e onu,nmas arerovennernaona unero. ,e enre conen o wcsn,c aonroruaeseere onnan rueaerrence,., “ ”,s “oe” u,n “ersooerena an oeerms “ ”, “ ”, “ ”, “ ”, “ ”, “ ””,, “ ””,, “ “ ””, “ ”, “ ”, “ ”, “ ”, “ ”, “ ”, “ ”, “ ”, “ ”,, “ “ ””,, “ “ ”, “ ”, “ ”, “ ”, “ ”, “ ”, “ ”, “ ”, “ ”, “ ””,, “ “ ””,, “ ”, “ ”, “ ”, “ ”, “ ”, “ “ ”, “ ” ”, “ ”, “ ”, “ ”, “ ”, “ ”,, “ “ ””,, “ “ ”, “ ”, “ ”, “ ”, “ ”, “ ”, “ ”, “ ”, “ ”, “ ””,, “ “ ””,, “ ”, “ ”, “ ”, “ ”, “ ”, “ ”, ”, “ ”, “ ”, “ ””,, “ “ ””,, “ “ ”, “ ”, “ ”, “ ”, “ ”, “ ”, “ ”, “ ”, “ ”, “ ””,, “ ””,, “ “ ”, “ ”, “ ”, “ ”, “ ”, ”, ”, “ ”, “ ” “ ”, “ ”, “ ”, “ ”, “ ”, “ ”,, “ “ ””,, “ “ ”, “ ”, “ ”, “ ”, “ ”, “ ”, “ ”, “ ”, “ ”, “ ””,, “ “ ”,”, “ ”, “ ”, “ ”, “ ”, “ ”, “ ”, “ ”, “ ”, ”, “ ”,”, ”,” “, “”,”, “ ”, reero a sneoman anoa comrseswoea or “ ” eav can amno v cans, eacavne corresonn orae ac seuence seorn an oae oae,ae,ae an oae or, eacoaavnee, coarreseon,na veara ore reaoen am.no ac seuence seorn avnee coerrrmess “onn a”m onro “ ac se”u reenecre oo aenone aene caa cno smrseswo cans, eac or : resecve or eacavne corresonn vareaoer : seuence oeoee can.n some emomens reon amno ac e corresonn varae reon amno , an one o or maave anormerzaonomane. ac seuence o or an aerenne eerm “suecn nee.,” as us aenoerren reeran or . sorer orsease assoc o a suecavn, susece oavn a serum or overexaeres wson.eer,m “sue ecxrnes nseoen”e a.s.,o e rxereessonnssue, ces or susece oavn asorer orseasea m rso a suecavn,aren . “suecn nee”ncuaeneromreamen w ann aen cancer. e a suecavn cancer or susece oavn roacece orrmu "mroearmreevne"noorn mureaossuerses o.usescosure reersooeraeucreamen an esorer as we asos cn nee oreamenncueose area w revene.uecn nee oerreoanemeonavuesnecuseor suere ocrsosae anre waomavee casorersoe oseroneoave cancer orosen wom c ncer as we as eerm “naura” as usene coneaxnc oersoe manae. naure. a seuence reerso a seuencea occursn e vaueese cromn “eamoua”e or. “an soromxem eameo” wmen rse,seeceo aven vaue meansa varaonn enera mean a rane wn-e rm “aou” or “aroxmae” sa ercen, wn-er rcen, wn-ercen, wn-ercen, wn- soe unersocen or wn-ercen o aven vaue or rane. suc as “romo”,ncouee eraecn,nav exuare vssaounes a rnee arnrn suo-r ranes o vauesneorma suc ranes.or exame,e exre ane comrse anncun maons sson “romo”ncues su-ranes suc as an wou comrse, “erwoemen anon”c, “uronm aon”, “,r.eo.m,,o,,”,, “r,om,,o,” or an. annvua vaues ncuees voauee un aners suooeroerre vanuesa.oere erxmam “ae,ease” wer reseco aven vauenenso ”, “aeas ”, “aeas ”, “aeas ”, m “aeas ”ncues “aeas ”, “aeas ”, “aeas ”,“aeas “aeas ”, “aeas ”, “aeas “aeas ”, “aeas ”, “ae ”, “aeas ”, “aeas ”, “aeas ”,eas ”, “aeas.”, as ”, “aeas ”, “aeas ”, “aeas ”, “a aeas.”, aeas “aeas.”, aeas.”, aeas.”, aeas.”, s useeren,e.erm”, “ aumeaasnze.”, aeas.”, an . anennnramen comr ” meansaenn aen suc as an ano or anma ano ses s or amno ac resueserverom non-uman reonserveesr,om ruemaonn asnerveromuman anoes, an wen acae,e consan s useerene exressooes. ac seuence o aramewor renon “su o aumveannzennram aewenor su rceo asn” an m aenansoa ore a anmneo nnramensencaoa o auman ano varae reon e.., aum n ano varae reon s anermne s useerenee exuernece. o one or more or aramewor rsesoonns “ oaraenunma anzeen” su mcea anss an aaneo am onro ac seuence ramens nooaencaoa o auman ano varae reon anennn uman ano varae reone.., aumanermn suc as aermne n somensances, aumanz e ano varae reon seuence. suc as an ano or ane e,uumanze oraraumanzenn aen o auman ano varaen renonne.ra.,m aenum maan ceormmrnese asnos o vrarae am renoon ac se rueesues “araumanzeramewor reon”us encomasses,o nce. maons, aumanramewor reona conans r exame an wou amno ac as ornaocaon ac-muaons renroucn an orna or e . “araumanzeramewor reon” aso encomasses, resxuaemase aenen w roumaons, aumanramewor reonn wc one or more amno ac s useeereace, ae oreee. eween ann ane,n oere arnm “eannn”n reeormsaonse serreeno an o a nnon a-ncoveane.n “nenrac”ons reresene w,eonr exeamne,newDe veanue,e a.en.,ene a rnao oenssonca aon raeo assocaon rae snoffeonoman ano reaces eur ene.., ano suc as convenona meonownne a um.e an maeeermne usn an meo, mcroscaeermooressr m,necuo,nu a-re no memoe aon, suroawce caosmmeonr ressouncance9meo.n anoeneraas aDvaue o-6e..,x-7,x-7as, , o-7r,-9x an- 8a,x-8-6,-8,x-9,x-9, x-9,x - r9ane orowe-9re..,nx v -a 9u-9e,.x -re-9era,, axn an-9o,xas a-9Dv,auexn-9e n,anomxoar -12,.vxen more,reexra, a,n anxo9as or aow vera eu.e.,nexco-1m0oa,r ranxe o -r11ow,ere.x - xx- -1122,x-12,x-12,x-12D,x-12,x-12,x-12.,, nn reae, ceormx n “es-1we2ecenc oro wonwe monr. e”cu ore “s,s suecc acsaor exnams” aes uesweeener aenn an reeorso a an no ann- arnanoem79e,ccxn -9 -7n, can-7e -9c,aracxerz -e8n,nxn --8a,n,-8D, vaxue o-9,-6x -e9..,,xn. x- -ae,nxe. , or an an vaue6canncae seccnneween ann s., u asneoer suc as sneoman ano an e..,uman . w” or “comenen w,e” reermers “coomee anor o annrs”, an “coome oer aonrenn-nn”,n “comraemes ereoe.., sneoman ano or anennnramenereoo enneraconeween an a secon an- anoe.., a sneon enn anenn amno ac rsn eer suea ersem onen man ano or s u n ane aneerrmeo e “neo a o wonec”e a asec n u asa nee oeerernee e. r.e.,ersoe seccrou o aoms or anoes mane same or a cose reae sneoman ano ns.wo comevennore anen.n eoe can eeoe wn an anen e ex amno ac resues sac near or conormaona.e.,ncun nn o a reerence aneo aare...o,r s enxameoem,an an an anoo oor ane anenennn areaasmen,o ocr as eanse s,a omre acoeases rea,een eeo aen asoe o rre aenrenecne- annno.raomren mae consereo cmerc,uman orumanze ano o exame, a monocona, a sneoman ano o r an anennnramenereo ma comee w s useeren,eerme "rsesenscosureornnouman . oen ewe euenceen" oeresennvenonncaeseeree comare wen ae mnuwaoon nu scucec as a scus oruwoon, amnsenroo anc o seuences wenes comare an en cane aeas , or ,ree reeons arorae.e seuencencu ra aeas .on-mn exames ,e,, , , , , , , , , , , , , , nnrae a menremn “aen. reoe”n orn “snneraommaenn asn” aos us oer annee exresson “ano or aneno aramen oe ano or sne ano nnnramenereo” reers a mancororae or n a encomassese anennnoman an exame amno ac resoue,s o oereornone rse oon,e am annoo ac o rres snuees oom aa conn ano suc asor o ac reon.earess o srucure, an a san reon,orons reconze e comee a nennnramennsoe same anena n anennnramneno o ae s.n., senoemaomnan ano. an seuencesa encomasse s anoncuesor examee s e enreeav can ororonereo an suc ma asnceu ener oer v naor,a oeer reoorno onrso orone aereo or eerm “anennnoman” reaesoeoron o an anoasno. anennn an comrsesor exame, one or more s nvoven ore enre varae reon , one or moreramewor reons oman anoer .eerm “anennnoman”ne conex o a sne nn an eo reaesoeoron o sneoman anoasnvoven anen , on ceom or mrsoesor exame, one or more o , or ooreor.one oe arm na “rae vnram e anenewo onrn re aoo smnsanvno”v ”, en, ne an con, eenx o o n ar n nae anv ene ar cne va omorae rse rreeoo rneaes one or more o , , , , or , one or meosreor exam caen, oreaevav c cana vnarraameewor reons,,, or one oro enre varae reons s useere reon anor can varae reon . , neerms “ ”, “ ” an “ ” resecve reeroe an or o an anoeav can. exame,noens mmeusn orz ann anen anmnan wra amens o aneeresenscosure mae oane,or oanereormna avera,re anoes or anennnran.mens oeresenscosure mae meos.nevnera aenn vs o roa an meno ooes. maeene n sco,n vro anorn vvo ra s re onenn o canae anoes or anennn eremoen msaereeoeno ane an mene.oss sunc an- anoes or anennnramens anor usn vovnnnoe anenscoseeren n an a esmsaosmsecno,seeeren. ane e:uma onro a roeonmoeoreoue o orr n o aor v c oao nrm oanrse umasv a anu am saenuence aeraosene..,encao oman ouman n roene.., an exraceuar emomen,e o:mooues a:, o seueencoem orooorueon or varanereo.n some n an emomen,e anens a ereo o armae. varanavn a seuenc uman , a omooue, a n an exemar eem aoeasmen,eencaooummoaonues cnereo or aramenereo. n anoer exemar emomen,e om omous . n some emomens,e anen c oouesesus . e.., oum omrsese exraceuaroman o n somane emo, omooue or varanereo. as reresenemen a,mneo acs anoen c oomrsesee. ex.,raceuarom:an or o nco:ro,ra seeeeoener e a., ,ea,. e a., ,e enre conens o wc are n someren reerence. an emomen,e anen comrses an eoeas commono anomoe c uman n s enmomoomuesn,e. anen co , o sro omo mrses an eoeas smarnuman ne c a emnomoomues onmso,oe. ue or ar aanmeenn comererose.s acmno ac resues- ouman comrse aoee comrsn auman a corn,e anen ma ac resues- o mno ac seuence conssn o amno ,n o or oer a emorm aeonra mso,me oenereo ue or a.nen comrses amno ac resues- ouman comrse aoee aramenereo.ccorn,e anen ma ac resues- or a cormamrsn auman amno ac seuence conssn o amno ne oer emomeenereo. uman , or o a nosm,oeoue or ar aanmeenn coemreors.esc acmornon ac, reesues a-ne o ma comrse aoee comrsn auman amno ac seu n ac resues- or aramener ence conssn o amno amno acn accorance wereseneo.scosure,e anen ma comrse aeas or reesaues ouman . uman armcunoar ac, seeuence co annssenns o a armanmoen ac o aeas amno ac resues o a n accorance weresenscosuree resues-. amno ac resues,ncun anen comrseseweeno amno ac resues,eweeonr examoe aemweneon aco resu aems,noe awce resues,eweeno resues,eweeno amno ac resue eno amno aco amno ac r s,eweeno amno ac resues,eween eweeno aemsnuoes a,ce rweseenues,oewee anmno aoc r aemsnues,o amno ac resues, amno ac resues,eweeno amno ac resues,ewoe aecn reosue asm,neow aecen resoues, amewneoe anc reosue asm,neow aecen resoues, amenwoe aecn resoues amno ac resues,eweeno eweeno amno ac resue ,eweeno amno ac resues, amno ac resue s,eweeno amno ac resues,eweeno eweeno asm,neow aecen resoues, amenow aecen resoues, amewnoee anc reosu amno ac resues, amno ac resues o auman amno ac seuen eseweeno . ce conssn o amno ac resues- aomrnnos aacnce sse,e anen comrses aeas amno ac resues o auman n accorance wuencee conssn o amno ac resues-. amno ac resues,ncunroers eexnamsceoseurweeeneo a anmneon a ccom rerssesuese,weeewno amno ac resues,eweeno amno ac resues,o eeno eweeno amno ac resues,eweeno amno ac resues, amno ac resues,eweeno amno ac resues,eweeno eweeno amno ac resues,eweeno amno ac resues, amno ac resue asm,neow aecen resoues, amenwoe aecn resoues, amenwoe aecn resues,eweeno eweeno amno ac resues,ewee o amno ac resues, amno ac resues,ewee no amno ac resues,eweeno eweeno amno acn resoues, amenow aecen resoues, amewnoee anc reosue asmneow aece resues, amno ac resues o auman amno ac seuence cons no . sn o amno ac resues- conssnn s oom aemnnsoa ancces r,ee anen comrses auman amno ac seuence n oernsances,seues- an ouman or aramenereo. conssn o amn en comrses auman amno ac seuence ne oeron ascan rcesues- ouman or aramenereo. conssn es,e anen comrses auman amno ac seuence n o o aemrno ac resues- ouman or aramenereo. conssn o amnnsoa ancces r,eseues- an oeunm caonmrses a oru amraanmener aemo.no ac seuence conssnn oe a omenron ascan rces,e anen comrses auman amno ac seuence conssnor o ex aammnoe a,ceesues resues a- -n o ,enu - cmoman ,r-ses, a ourm aanramene armeon.o ac seuence -,-,-,-,-,-,-,-,--,-,-,-,-,-, n somensances,e anen m ,-,-,- or-. . a excuee cseneoor oman o :.n exemar an non-mn emomen o a anensroven nn acceonr one,nre ssoenme esmcoosurmeesn,enn aen, or anennnomans oe n some emomen,enn a caeae onnuman . oeresenscosures caae onnn,u omr aannenn ann conmomanosu osen.n aen oernes seonme escmosouremerne,ereenn aen, or anennnomans oenn aen an nansouman over mouse oras aeer nor somumea enmomen ov,ere mouse . oeresenscosurereerennan anesn,o oru amnanennn oveormans oenn aen anor ra oras aeer oernes seonmumea en scmosouremen ov n,er soe ra amnnon ac a.e rnes, oru aensaen aren conmmoonmaonse e oxraceeunarno amen ouman anoe exraceuaroman o cnom an n some emomen,enn aen, or anenous . oeresenscosurenso amno ac resuesan aren noomraesnens onee enxn aen oman o mo raceuar o n somues eemome.n,enn aen, or anennnomans oenn aen omaen ores reanscos.urenso amno ac resuesa are noresenne exraceuar oernes seonme enmsoo ammenno, ace rnesnu aen, or anennnomans oenn aen , cnomous , mousesa areresenne exraceuaroman ouman ccorn,enne an ra . caae o aen, or anennnomans oenn aen mae n exenmnaro emuman ano cnomous . aen mae caae oonmnenso, aeenanurne aoermn, ourm aannenn.nomans oenn nn an aenno mear exeem caaare em oonmnenso, aenn aen, or anennnomans oe ne oer exemar emom reuceorm ouman . enn ae ens,enn aen, or anennnomans o nn a n mae caae onno aecosaeorm ouman . canscxee omns searer eemn.omens onn aens oeresenscosurencues aoee anenxnemnarra emmeonsmeenrs onn aens oeresenscosurencues anoes or anoexse omr anare enmonmneneo rsa o. mennsner aeoen osr snereeoreomnacnu aen wooeus orm anaoenns, nnave ramensereo or varansereo suc aso n anoes r exame,umanze, cmerc oruman anoes o orr an anenennnnnrarmaenmsenseereo orumanze or cmerc sneoman arcuarn ceonoemmanae an aoes or anreeno.nnramensereoscoseeren are omans o one or more ssn weeo amsann anno aeensa comrse one or more anennn neoman anoesa comee wsscoseeren. an amno one or more sneoman anoesavn encomasse ac seeuernecseen asscscosousree.erenorenn o a anen are aso aens comerr esxnem anare enmonmnenosm oann aens oeresenscosurencuenn can ano,roen scao moecuens asn sumcm ausn aen ceo mo-uea moecuesncun sne ccorn, exemar emomens onn ae n aens. ano-e moecue ns oeresenscosurencue sne anoe sa comrse one or more anennnomans o one or more onsa esxcoseeren. roen scao moeecmuesara em comormseen osne onn aens oeresenscosurencue sne an or more anennnomans o one or more comrseseo m aes muneosnc caos e ee mxoemere uaarn. n e amenosmean csom orsen onne o ar menors oeresenscosure o one or more sne anoess e anennnomans nnranmnen asenerseon acsu wenc aso sros n eexeamere omen an a.n an wooeus or amnaeonns,n annoraemse onrs anen a comees w o a sneoman anoavn an a ereo are aso enco mno ac seuencescoseeren nnoem marenssea ,nsse wesrceons auereres easuesn o rneeasc oesos eour o ae. nen orn aen comrsn one or more anen anennnra more anennnomans comrse an . menereoas caae onnorooas ce surace anen- e exrance soumaer emomoamens,enn aen oeresenscosures caae onno e csenn seo-mrce emomon anm aenns, o oenn. aen oeresenscosures caae onno n some emomens,reonerooune-oman o . an eoe comrsn amno acs one e axreance ouaeroremseann oscosure.s caae onno an eone s coomme ermsno ammennos, aenn aen oeresenscosures caae onno oman cs oe csene-rcoman anor oerooune- an eon o e sonmceu em. no ammneon asc, reesnuens co amenrs oe werense anmnosc acosur seesue cnacae onno or aramenere e- o nnn some emomenos.,enn aen oeresenscosures no caae o nno somee c esmenoe-moeonrsoman o . n ,enn aen oeresenscosures no caae o ano somee am emnoo acmens,oen on a. oman en comrses an anennnoman o a sne nn n s oomo eer e emm ca ooa mme ee o nns,nennn a.en comrses a sneoman ano. s on a so smnee emomoamne ans ns,,e oe annnen anenns ao smnane oomeann anno ae.n comrsese n some emomens,e. reon o a anennnoman oenn aens a varae or .n s sonmeenosmaancne as,neo.n somensances,e varae reon mae a came ramewor reons suc as came vararame reewoorn comrsesor exame, came s an ramewor reons, mouseramewor reons reons,umanzeramewor reons,uman s on c saommee em oronm aenns,umenn aen.s comrses a varae reona comrses s on c oameer em oronm aenns,umeanz anne ramnra ew am oee rnwo rsr e co r ome nsrosness. a varae reona comrses sneonm saomne an emoom eaecns comernsnn a aemner cozmaor. nsesomwaoneaevre caonrm vanra ae rmeero.ns o a cacuaen soamsee e omnomens,eeve oumanzaon o a sneoman ano mae eercenae oumean sezaueonceenoe cosesuman ermneene.ccorn, an .n accorannce sc wores ana esmeo onmreanm,ewor reons- ,, an accouneor assessneeve oumanzaon o a snee seomuence o an are no easn. exemar emomens,eeve oumanzaon oaen ansceonsenernen.omans a sneon oer exemar emomens,eeve oumanzaon oe varae reon oe nm saomne an emoom oenes,reesennsnco asuernes o aeeasres. moreoee cans eacneenen comrsnn aen-oscosure ma comrse one or ac seuence oormua: -ermnaason an amno -a- --- - eren ms,,b m c dneren ns,, o orr a anneerreaeran eren m an n are nonn seerreaeran anerena,, eac reremseunasn aenou ansennnoman weren aeas one oe omaennnndom ora anns ans ane annnennnomnanoman , an anennn seueren or areneenenresen or asen an comrses an amno ac eernce ereennb, rec, eraecsenns aeemneen comrses one or moreners an aeas onn seo ome emeoomeense ceanr nsnza com aoen rnse coommarn.ses one or moreoee cans weren ormua. sormua:-a1-b1--c1-d1- aeas onn seom oe emeoomeensee cannsn co amerns ceosmrses one or moreoee cans weren c2- ormua:-a1-b1--c- - aeas ondn s2-ormua.1 d1eom oe emeoomeensee cannsn co amernse csomorrses one or moreoee cans weren c1- mua:-a1-b2-a2-b-- nds1o-meormua.1aeas one o emeoomeensee cannsn co amenrs ceosmorrmseusa one or moreoee cans weren c1- aeas ond1-c2-d2-ormua. :-a1-b2-a2-b1-- n seom oe emeoomeensee cannsn co amernse csomorses one or moreoee cans weren c1-d1-- -- -ormuarm.ua:-a1-b2-a2-b1-- aeas onn seo omece2emood2meencs3e cedann3n aen comrses one or moreoee cans weren b1-n s-omce1e-mod1m-enc2s- s comrsesormua:-a1-b3-a2-b2-a3- ed2n-n aormenua. abe1a-s one oeoee cans comrses coomrmrusaes one: or- morae1-ob3e-ea2c-ans w-eren- an anenn s-c1-d1-c2-d2-c3a2-d3a3,-d1ordm2uad3.b2 a3ome emomensa1,, ,, or, eacneenen comrses or anenn somn ne en nmroom amma een nn.sebr1e coom.nr ssoems ae enmeor ormennes,rs aenor ane reon o an ano a naura occurrn ano.n ex ne reons ane reon o seu emar emomens,ene ma comrse an amno ac oeren emce aos seorn :, :, : or aoronereo.n some emommeennss,,ee mnuea ree oorn ssn a meucaen ore s mnecne reon asscoseeren.n , aeas , aeas , ae aave a seuence aeas , aeas ane o a naura occ as , aeas , aeas , aeas encao ne maave a seuencuerr asn se anoron.n an exem:ar o erm aoormonen,ereeo m.uae or snec emomne snosm,e eemnoem reenosn,,enern oer s reon mae reace aner or sacer.n some ners ans sosme emomensb2,b3c1,acce2,r a anre oc3o enaac.neenen comrse aner or meraoncooseeren. oen aecc corm anaa sncn ee a ac wnne comers rsrensen ones ocro msuorree, aneennnn aneno mae comose owo oman.e one or more anenn mans an amerzaon xemar emomens onomans mae searae ners. e onecememerzaonomans anners areroven ,e enre conen or, , anuse onune, , unero. n some emome wcsncororaeeren reerence. n some emomennss,,eemmeerrzzaaoonnoommaann a aoowwsseeoorrmaon oomomers. n some emomens,emerzao maon oeeromers. conuo noman comrses an amno ac seuenceas merzanus on soomoee am ma emno n.o acmere snesm,uenc erzee o aonmeer a omznaaoe nnnn snoomnano cmoamn.rses anmmunooun conemaeerenncune wno aerson sene ar are n some emomens,uecnmee zrzaeros,n ec. merzaonomanromum oman comrses an,,, or or aorn some emomens,aen omr aenrzmaaonosms,an co,mrss,es a cso onrsans re.on o an ano orno an snomeer eemo. eaovm ceans,e consan reon ororonereosrom an , an , an ereo comrses amno acn o sre coumencena oo annereo.or exame,e consan reon ororon comnaonereo.n somensancese amno a,c an seue,n acne oe o cro annsan reeoav can or ereoe.., omans aeas encaoe seue n ororon an , an or an eav can. nce o a naura occurrn , can.n some emomens,e consan reon ororonereosrom auman eav can.n some emomens,e consan reon ororonereosrom auman eav can.n some emomens,e consan reon ororonereosrom auman eav can.n some emomens,e consan reon ororonereosrom auman eav ereo.n some emomens,enn aen comrses ac reon o an ano or aoron comrsens socm meo emcomens,enn aen comrses ac reon or aoronereoa n an exemaons or no. as caae onarn emo aonmce renc,eoer on mnono acenes m aa comrse ac or aoronereo n anoer exemar emomen,e nor macroaes. ereoas caae nn aen ma comrse ac or aoron oronne oreoer. emor eo o xammenn e,s,n eeo an c rnc en rec on ae orenor or c oon omnrses a mna acroerea oers. muaec reon or mo one or mor ereo mae aere or muae so aso ororonereoes c unaracceorssacse o.ne onern e aen.n exemar emomens,ec reon ereo com xemar emomens,ec reon ororon n orerse es one or more oec mocaons oae. asoncreasexem acarv em.oorm exeanms,e,e ac reon ororonereos aere or muae so numern ssem ma resun anncreaseucoscaonne.n., onn a ccecosr aannce m waoeen rnecruecaese nume.r occourconse,n some emomens,ec reon ororonereo maave a aucosaec reon oro rersonues.ereno o.nere em ooerm eemns,enn aen comrses an ereo oenn aenacsucose resues.n aoonam eemnso,meencs, reeonc o rreoorno onr reoroonn orereo oenn aenacs coreucose resues.nurer emomens,ec n soormeon emeoreom oenenn aenuacs coreucose resues. n some emomenss,,eemerozmaaonnso am naaunr comrses a oman. n some emomens,emerzaonoman aaso comomrsaen or a muae oman. emner szoameon emomoamne mnas, aseo commerrzaseo anoman comrses as aomaonm oan a.n ano. n some emomens,e o oman o an ano. n some emomens,emermzaanons ao nmaaurna oman or a muae oman. naura comrses a naura oman an a muaen somoem eamn.omens,emerzaonoman comrses a naura oman an a nauran someo emmano.mens,emerzaonoman comrses a muae oman an a muaen somoem o ea mmn. anomens,emerzaonoman comrses a muae oman an a or a seune snocmee a emeao. smens,eneca, aoemasan maaeve a seuence as seorn : encaereo nca, aeas enca, aeas or a seune onceer a e.meaosmens,eneca, aoemaasn maaevnec aa se, auenecaes as seorennca, : encaereo aeas or a seune snocmee a e.meaosmens,eneca, aoemasan maaeve a seuence as seorn : encaereo. nca, aeas enca, aeas or a seune snocmee a emeaosmens,eneca, aoeman maave a seuence as seorn : enca as enca, aeas enca, aeas seuencen a se sor smeo ee. o emronmens,e:m oerr aza seonoman ma comrse a omanavn a aeas enc uence aeas enca, aeas enca, orn a:, a orea ass seorenncaereo an: a or a seoumenacen aavn a seuence as seeas enca, aeas enca, aeas eas enca, a n some emomens,emerzaon encaereo. seuence as seorn : or a seuenocme aane masa comernsec aa, aeasomanaevnn a aeas enca, aeas encaereo an a oma ca, orn : or as seorn : o navn a seuence as seeas enca, aea r a seuence aeas enca, a n some emomsensenca, aeas encaereo. : or a seuence, aeeasmerzaoenncoam,a ane masa comrensee seuence seorn aeas ca, aeas enca, n so:meen e omca r aoe semre ueo enncs. e, aeeasmerzaoenncoam,an ma comrsee seuence seorn aeas encaereo aeas enca, aeas enca, n so:me e omr ao semueenncs. e, aeeamerzaonoman ma comrsee seuence seorn aeas en s enca, aeas enca, aeas enca, reon on s aom naeu ermca ao ocmer cee uno rr,. ne anmeorza oron anomeann cnomnrseras amenne reereoon suc as ane snecne or a muae or nn s soome r eemoon.men,emerzaonoman comrses aecner. ,, orme e ammnoo amcen rse,seuesnneresn an a.mno ac seuence o aeas,,,,,, nn s soommee emomen,eners non-ceavae. :. emomens,ener comrses one or more uns o :n w soemreen em nso anmnenes,er seeecneer mroam coomr,s weereenormusaresen onsome emomens,ener ma comrse r asen ans.n n some emomens,eners ae seuence seorn :. some emomens,ener ma comrsen aunmaonnen ore a seorueonnce oerre aoo.or exame,n some emomens,ener ma comrse ronereo.n some emom uman ne seuence or aoronereo.n e oer emoenmse,n,eenenre mra ma com comrserseumuamna ne seuence or aoronereo.n noes an anennn n ne seuence or aoronereo. ramenn soemreeo e.mosmoenes u,neram ersnen oons e areenns an an- ano or an anennn mn emomens aeoown reresen exemar an non-mmunzanono oes an or a a o nn an maeno nnes cun or nr aan ame caen mnesn , aerneaora mao,rme aen rors seeureenoc.e mae oanerom anma w a anen assc mear, an aaca, aransenc anennnramensereooreosre seueernecne. moar exeam oae,ne snemommuann anoes or suc as aromear, a came, aama, an zn an anma ramensereo.ern aaca, a ra w a anene.., or omanereo mae oaanvee,em smeunuezncne o ar aan ssnenec aonmmaan anaos a or anennn oman anoesseenernaona aca eo exress sne anuse onanuar, , uneroo.no. e enre onu,,ncorora e conen o wcs oanene r soommeere sernn usman oc r rees,er ss ae unnc e ae on. momun orze anennnramenereoors seuences noes. anmas suc asone marrow, seen anorm anmmnoraromasamaa r ceesus surcom ausson m oe coemsa o c aensmmaucnzne anma w a manan osorosranserase an enzme oxanne-uanne- oxanne-amnoern-mne ma aown cesorown meum eneraeromas.e ano or anenenenenraera.meneen ceereos a mreaarecsuoaare usreomuo roma an oanee. nuce acm acc saeounen acne s oe aunen acnnorom o cr anennnramenereo mae anennnramene es orssue aeo exresse ano or nu reo.e amno ac seuencenormaons oanerome enccoecn ace s seamueen acme.nou aeco senuereneenerac oeenec coe, a nucec ac moecue e orn enceuavn aeren nucec ac seuence comareo nace n auc nuecce ac seuence maeenerae. recomnan exressco anc o se anue annce eoncosn renee armenoo asc seuence o an anos oane, exresson vecorsn seransecon o one or more ernave,oe smemuoernaceze mammaan cenes. e oane screenn an esas oe an an anoo ora arnoern senuenncesraameanveeerseore mae aso suc asor exame,omoo oren w a reerenc aures noes oeresenscosurencues naeve an orona. no . nave ornac anoncues an a c anoesa seccasoaerommmunze anm noas recomnan exresse, xemar emomenass o orrnomn an aenrs oomae. anennnramense resenscosurencue anoes or acs o reoa seccano aeas one eoe comrsn amno ae e exraceuaroman o .er exemar emomens onn secnsc oaenresoen aeascso osnuere encouee co amnrosnes a omrn aonennnramensereoa .n some emomens,e anoe acs oe csene rcoman o anenscoseeren. s or anennnramensereono a .nn an an eomeor emmeno,meen an,oe aens ooees oreseneresscenosuresc soesccanouman cnomous .n anoer emomen,e anoe ure secca no noesus . s oeresenscosure secca e ooreumarancuar,e anoes oeresenscosure seccanoe or ammaa nnaevaev or cnaancs a a. ren caoss ceom asr asesa,weoa,ea evson, caans anwo cans. consss o a varae reon an mma, an mu, eaceav can ,,, re ars, secon,r, an oonaour consan reon c secve mammaan cans are casse as or κ, we eac wea sne cmon ossse o a v caornsasen re oone sec aonn a an consarn c reonson.e anoas a “” sae, ounoeer vasueonn.ac a an reons owoeav cans consan reon o a sn rm oencuese varae reon anrs can.e varae reones oeave can aonuneaov ce vaanrsa aree a rens coonnssaeno rerons o a sne varae reonsno cansenera conanre anennn.e comemenareermnn reons s cae varaeoos caee no,ese aanv a cnaenn-ns n sncun , , an a nncraumnensscos,eeren, mae.ene orounearesore convenons oaa, ,oa, or-azan.eree s are ne e ann srecesnown asramewor reon neroseeween , an ,eav cansncuns,s , can, ansncun, wc a, , conserveane s anorm a scaoo suore var re more consan reons oeeav an cans are nonv aeoos.e varous eecoruncons.noes oven anen-nn,u ex oe consan reons oereav c araen ass.sneevoe c maassoers caasssees o one amno ac seuences ,,,, an , wc are caracerze e rsoes o anoes are amma, an mueav cans, r resence o aa,ea, eson, sucasses suc as ammesaecevave. ceavner,a oe mamamora aneaov c caassnes, arevaemmnao ceaavn. can, ammaeav can, aaeav can, or aaeav .n comeser oc aneroesenss ac roescuormenncaunesr coemnerca an conoaenssae s vaercacae renoncune comemenareermnn reons s o an anoerve ons more seces, suc as a roen ano, wee cons rom one or erveromose o anoer se anomans oe ano moecue are noes oeresencessc,o ssuucre asnc auuman ano. o .umanze anos a recomnaesumanze anoesa seccan rom an anorom one seces e. nroenn wce s or resues varae can ., a roen ano, areranserreromeeav an ramewor reon sse ouencees ro.ene c aonnsoanonmoanusm oaneea avn aon moe vcaureae reonse.., ose o auman ano.n ceran emomens, am areerverom ac resuesromearenr e numer oramewor reon amno ramewor reon seuences.n ooeenr ex aamnoes, as m same sruansseurren mnoouseeumsann aonumoan resu oreenn re osruesron a re rseoruecoen o orr evnean aossn o a onoe mu arnne an, aona mocaon m e e reacemen o one or more someum o.s cane accomse counerarso oan an a an resuesne reons wer murne emomeneumannoaossessesoonn anos eoe.n some emomens, au ze anos aumanze sneoman ano.n somes encom manze anoa comees w a sneoman anoscoseeren .nass uoeesu oe maneres anreensoensco cass ncuore esu. oreannceuesuman anoesa seccanso orroucnuuman rom aransenc non-uman anma.eosransorme wumanm anmunooeos uusnno ec aerre conmownnanorae a ar.ronac ones orransenc anmas saecnue mae useoeneraeuman ano e aernave,eae execeo ex evenewer se eecs es.euuman anoes aren vvo as essena enoenousuman anano cmese.rcn o sromuem eamnzoe amnenos, aesu anmano anuncoon asco cosumreees w a sneoman anoscoseerens encomasse eresen seccan.onesso oe.resse unsesceroesnureen excureessso snns “senoemaomn anoesssa can on ano” are usenercanea.eerm “ an ano” an “eav roa sense anncues naura occu sneoman ano”s usens woumaons rrn sneoman anoes or varansereo suc as, sneoman an,oumansz sea snoee commaenr acn woenes oro cssemsseersc a s cnonseanom reano ann ooes. seces.n an emomen,e sneoman anos a cmerc sn anoer some emomens,e cmerc sneoman ano com eoman ano.n an auman consan reon.n an rses aumanze varae reon comrsese varae re oer emomen,e cmerc sneoman ano ano” aso encomass monu oae a v nearsvoens sn oe naoumraan o acncurorn. sneeermom “asnn aneoomaesn muae versons oumanze sneoman anoes as we muae ve , sneoman anoesn wce amno ac seuence c rsons o cmerc eeons a omrses amno ac susuons, snnore aomaonns. oman anos aou an-os s usua comose owoeav cans. sne seecvenoare anens,ean szeaou amno acsnen. s can owever,ec u-sze anoes, anave smar anesor anens.umors.e samuasee or szeer a msouc con smraueres szoe,ee sa mae o caae se o,e wercense mraoreonno so anemeraure exremesanu sze anoesanerne ressano osc :-.ne-oman anoes were ornanev eeo a.e,o,ocm scovera camescames, aacas,amasossessuun owne canse..,amsen e a.,, croooecno:-cona anoes wou oman anoes conss o a sne varae re .aura occurrn sne an .e varae reon o naurao oncc or anwo consanomans cone anuseo a consan reon o urrn sneoman anoes mae emomens,ecoma a naura occurrn anoeav can.n some or acoronereo o anu om aan naura an ococur.rnn s somnee emomoamne anns,oesea rve cacean w cons aanc r ceaonn c oon as nanau rreaon oc wcurcrn co smnreseoman, ano ans reaocmea wns ana o oo anuman eav an ma oona comrse ane reon.n some emomens a oman reon o a naura occurrn sneoman a ,eeav can consan oman o auman eav can an ma ononao cos reace w a or - e anennnroer o a sneoman anmorses a connee reon. varae reon.s suc, a sneeav can or ev rre eeav can mae sucenor seccnno an a en a sneeav varae reon or comose owoeav nen.owever, a sneoman anos usua su cans.ewoeav cans mae asseme va amerzaonoman mac a assoore ex eaxmre a consan reon o a cassumanmmunooun.ewoeav cans ccoesse as a sneoee can. ramensrereno su,cn s aosm,eo erm exoammeen asn, wnnou aemnsanconus,e s anneooems an anen-nn cames or sars,uman anoesncun sncu an anoesrom ,uman ,umans,umansncununmanuman ,uman ,uman s,umans, anma anoesncunor exame anuman ,uman , ,s,s,s an s an varanse.., c,mersc,uma,na, , c, a smarorm ze orumanavn ramenns o suea cr e. amsomens,nn aens oeresenscosure encomass anen-nn eermn ,or exame an woumaons,a,a’,a’2, comemenar nn an reeonns, varae reonsncuns, s,s, anee. ros nnramen canereare nownecnues suc asroeoc or s o au-en ano or exressonn. co or anoeros oe con u-eenra amneno.ens an ceonnvennonnar maemeons c.anore ex oamanee, aneensnn ornaaraneson o rouce enzmac ceavae o anoes wesnorove men cane ramenenoea’.a’ramen caneurer ceav an aroxmae an oona aocn2rouo2re surrou e usn ao reucn aen, naes,orouce an aroxmae a s resunrom ceavae osue ceavae usnaanrouceswo monovae’n moanovraaenmenrasm anen a.ncernraamveen, anre ecnz.mac “muns seocmec e amnoome”nss, a ann anooesaa cannsno smuan caenouseos aeceacs orw mouarsecc. are oeren srucure, e..,wo or moreeren anen esa e same anen, or aaen anor s,wo or moreeren eoes on a cann smuan an anen or eoe. “muvaen ano”s an ano a eouso aeaswoaresa are oe same oreren srucure.rvaenecnn orc mauesvoawen m.anu anvaeenncnnrovoemsa anns ane anoo was.e., monovaen,vaen,neraconsnnno an anen,usncreas an avanae o mue eccncaesow man anens or eoes anne av onnoe anen. secc,rsecc, musecc. anos aeon.e., monosecc, vaenecauseaswo sneseenons, a nave anoe.., an s amno ac resu anennnomanseacnnomanen comose o eca esrome can aneav can varae reonsus monosecc anuosee esacnc aunee annonensaomaanve mnosreoane o snaeme an eeone.nnusoemcanc, o muveaen secc. “secc ano”s an anoa cann smuaneousowren wc are oeren srucure.secc anoess ansecc a oares sa maave aeas anennnomana seccansono.ramens musenc ac anonooe rse acroemnnoawnn, aescnoscoosees,, nourm eexraomus meeosoroucesecc or xames secon o wcsncororaeeren re,n..a.o.,,,e rouce euaroma meo, wcn erence.secc anoes cane roucn a monocona voveseuson owoerenromas, eac roucnsecc an aoneso use rsecoeenroznun aconearen cro asns-nenercs soe. cenmocaer meeeoror eren monocona anoes wo neoman ano . n exemar ees ano.so momen onn aen oeresenscosures a sneoman emome e unersooerenaeoown reresen exemar an non-mn ens o sneoman anoes or anennnramensereo. comemena srneeeormmannn a rneoonossesse os une suenscnoseeaeurreesn.oromrs e axaomoe,ne nmo anor aocove re wsunes oe cesene rc ano omaneramew oore re exoraceuaroman o . resues o csene rcoman an n nerac w amno ac roeresrove oeerorm a c aroune .ese unue amno ac resu aes o ane co om semesnoarr eer amnn an sow reosnsocaon rae. aunrrsn, comemenareermnn reon o no aearonera oe oe . c w amno ac resues suc as ane snoe-eomenanen an ceouaers c ooeoxcresenscosu arne aosro anossoess- ane-ecnancer acv aocoss acv.e sneoman anoes oer en ceuar conuaeoreraeuc, or esenscosure ma asoe anoexse omr aanr eemnonmenes oeconn unses a.ens oeresenscosurencue sneoman comrsn amno acs onrea emxernacseueraeroomaan secca ono a.easer on eexe emoare e amnoenmennsn oranmenns aeenreso oae sercesenscosurencue sneoman anoes or acs oe csene rcoman o .cna somen emoo ameeanss o,nee e snoee coommarns ann aomno or anennnramensereono a anenscosee es n an emomen,e sneoman anoes oerese ren.ouman .n anoer emomen, nscosure seccan seccano e sneoman anoes oeresenscosure eresenscosur cen somous .n anoer emomen,e sneoman anoes o orearceccanoesus . oe uar,e sneoman anoes oeresenscosure se ereo comn or ccan n ar esxeee smear o emumoanmen,e. sneoman ano or anennnramen ac seu amno ac seuence oe seorn : ane amno e en scee oe seorn : an oonae amno ac seuence o :o.rn : anore amno ac seuence oe seorn ereo cnom anr esxeesmea arm enmo aomen,e sneoman ano or anennnramen ac seuence oe secor senuence oe: an se ooronane amno: ac an seuee amno e seorn : anore amno ac seuenc nce o :. e oe seorn aereo cnom anr exseesmear am emnoo acme sne,uenece sn oeeoman a sneoor onr anenn:nr aanmene semuneonc aec o seeuence o seoern seorn: anor:e am ann oona e amno ac seor o ac seuence oe ereo cnn om anr exseesmear: am em. noo acme sne,uenece sn oeoman ano or anennnramen amno ac seuence oe seor e seorn : ane seuence oe seor n : an oona e amno ac seorn :.n : anore amno ac seuence oe ereo cnom anr exseesmear am emnoo amen,e sneoman ano or anennnramen amno ac seu c seuence oe seorn : ane seue ence oe seorn : an oona e amno ac seornce oe seorn : anore amno ac seuence oe aereo cnn om anr exseesmear: am em. noo acme sne,uenece sn oeeoman a sneoor onr anenn:nr aanmene semuneonc aec o seeuence o seoern seorn: anor:e am ann oona e amno ac seor o ac seuence oe ereo cnn om anr exseesmear: am em. noo acme sne,uenece sn oeoman ano or anennnramen amno ac seuence oe seor e seorn : ane seuence oe seor n : an oona e amno ac seorn :.n : anore amno ac seuence oe ereo cnom anr exseesmear am emnoo amen,e sneoman ano or anennnramen amno ac seu c seuence oe seorn : ane seue ence oe seorn : an oona e amno ac seornce oe seorn : anore amno ac seuence oe aereo cnn om anr exseesmear: am em. noo acme sne,uenece sn oeeoman a sneoor onr anenn:nr aanmene semuneonc aec o seeuence o seoern seorn: anor:e am ann oona e amno ac seor o ac seuence oe ereo cnn om anr exseesmear: am em. noo acme sne,uenece sn oeoman ano or anennnramen amno ac seuence oe seor e seorn : ane seuence oe seor n : an oona e amno ac seorn :.n : anore amno ac seuence oe ereo cnom anr exseesmear am emnoo amen,e sneoman ano or anennnramen amno ac seu c seuence oe seorn : ane seue ence oe seorn : an oona e amno ac seornce oe seorn : anore amno ac seuence oe aereo cnn om anr exseesmear: am em. noo acme sne,uenece sn oeeoman a sneoor onr anenn:nr aanmene semuneonc aec o seeuence o seoern seorn: anor:e am ann oona e amno ac seor o ac seuence oe ereo cnn om anr exseesmear: am em. noo acme sne,uenece sn oeoman ano or anennnramen amno ac seuence oe seor e seorn : ane seuence oe seor n : an oona e amno ac seorn :.n : anore amno ac seuence oe ereo cnom anr exseesmear am emnoo amen,e sneoman ano or anennnramen amno ac seu c seuence oe seorn : ane seue ence oe seorn : an oona e amno ac seornce oe seorn : anore amno ac seuence oe aereo cnn om anr exseesmear: am em. noo acme sne,uenece sn oeeoman a sneoor onr anenn:nr aanmene semuneonc aec o seeuence o seoern seorn: anor:e am ann oona e amno ac seor o ac seuence oe ereo cnn om anr exseesmear: am em. noo acme sne,uenece sn oeoman ano or anennnramen amno ac seuence oe seor e seorn : ane seuence oe seor n : an oona e amno ac seorn :.n : anore amno ac seuence oe ereo cnom anr exseesmear am emnoo amen,e sneoman ano or anennnramen amno ac seu c seuence oe seorn : ane seue ence oe seorn : an oona e amno ac seornce oe seorn : anore amno ac seuence oe aereo cnn om anr exseesmear: am em. noo acme sne,uenece sn oeeoman a sneoor onr anenn:nr aanmene semuneonc aec o seeuence o seoern seorn: anor:e am ann oona e amno ac seor o ac seuence oe ereo cnn om anr exseesmear: am em. noo acme sne,uenece sn oeoman ano or anennnramen amno ac seuence oe seor e seorn : ane seuence oe seor n : an oona e amno ac seorn :.n : anore amno ac seuence oe ereo cnom anr exseesmear am emnoo amen,e sneoman ano or anennnramen amno ac seu c seuence oe seorn : ane seue ence oe seorn : an oona e amno ac seornce oe seorn : anore amno ac seuence oe aereo cnn om anr exseesmear: am em. noo acme sne,uenece sn oeeoman a sneoor onr anenn:nr aanmene semuneonc aec o seeuence o seoern seorn: anor:e am ann oona e amno ac seor o ac seuence oe ereo cnn om anr exseesmear: am em. noo acme sne,uenece sn oeoman ano or anennnramen amno ac seuence oe seor e seorn : ane seuence oe seor n : an oona e amno ac seorn :.n : anore amno ac seuence oe ereo cnom anr exseesmear am emnoo amen,e sneoman ano or anennnramen amno ac seu c seuence oe seorn : ane seue ence oe seorn : an oona e amno ac seornce oe seorn : anore amno ac seuence oe aereo cnn om anr exseesmear: am em. noo acme sne,uenece sn oeeoman a sneoor onr anenn:nr aanmene semuneonc aec o seeuence o seoern seorn: anor:e am ann oona e amno ac seor o ac seuence oe ereo cnn om anr exseesmear: am em. noo acme sne,uenece sn oeoman ano or anennnramen amno ac seuence oe seor e seorn : ane seuence oe seor n : an oona e amno ac seorn :.n : anore amno ac seuence oe ereo cnom anr exseesmear am emnoo amen,e sneoman ano or anennnramen amno ac seu c seuence oe seorn : ane seue ence oe seorn : an oona e amno ac seornce oe seorn : anore amno ac seuence oe aereo cnn om anr exseesmear: am em. noo acme sne,uenece sn oeeoman a sneoor onr anenn:nr aanmene semuneonc aec o seeuence o seoern seorn: anor:e am ann oona e amno ac seor o ac seuence oe ereo cnn om anr exseesmear: am em. noo acme sne,uenece sn oeoman ano or anennnramen amno ac seuence oe seor e seorn : ane seuence oe seor n : an oona e amno ac seorn :.n : anore amno ac seuence oe ereo cnom anr exseesmear am emnoo amen,e sneoman ano or anennnramen amno ac seu c seuence oe seorn : ane seue ence oe seorn : an oona e amno ac seornce oe seorn : anore amno ac seuence oe ereo cnn om anr esxeesmea ar: m enm. o aocm seenu,encee o sneeoma sne anoron or anen:n annreamen ac seuence oe seorn : aon ac o soenauencee amno e seorn : anore amn o ameno ac s seeueonrce on ereo cnom an: r esx. eesmea arm enmo aocm seenu,encee o sneoman ano or anennnramen ac seuence oe seor e seorn : ane amno e seor n : an oonae amno ac seuence o :.n : anore amno ac seuence oe seorn ereo cnom anr esxeesmea arm enmo aocm seenu,ence sneoman ano or anennnramen ac seuence oe seorne oe seorn : ane amno e seorn : ano: an oonae amno ac seuence o :. re amno ac seuence oe seorn n an exemar emomen,e sneoman ano or anennnramen acere soe cuoemncer osesee amn soe acor senuence oe: a sne ooronnae : ane amno e seorn : anore amno ac amno ac seuence o n an exemar emomen,e seuence oe seorn. cereo comrs sneoman ano or anennnramen a ese amno ac seuence oe seorn : ane amno e seuen sece ooren seor:n anore am:no a anc o seouneance oe aemno ac seuence o n an exemar emomen,e sneoman an seorn. ereo comrsese amno ac o or anennnramen ac seuence o seuence oe seorn : ane amno e seoe seorn : an oonae amno ac seuence o n an exremnar emom:en a,neor snee amonmoa acn an seuoence o or aneenn senorn. ereo comrsese amno ac seuence oe ramen ac seuence oe seorn : a sneorn : ane amno e seorn : anore a oonae amno ac seuence o n an exemar emo mno ac seuence oe seorn. ereo comrsese amno acm seenu,encee o sneeoma sne anoron or anen:n annreamen ac seuence oe seorn : an oonae amno amno e seorn : anore amno ac seue ac seuence o . nce oe seorn ereo cnom anr esxeesmea ar emomen,e sneoman ano or anennnramen ac seuence oemn soe acor senuence oe: a sne ooronnae amno: ac an seuee anmcen oo e. seorn : anore amno ac seuence oe seorn ereo cnom anr esxeesmea arm enmo aocm seenu,encee o sneeoma sne anoron or anen:n annreamen ac seuence oe seorn : amn aon ac o soena amno e seorn : anore uencee o ameno ac s seeueonrce on ereo cnom an: r esx. eesmea arm enmo aocm seen,e sneoman ano or anennnramen ac seuen uence oe seorn : ane amno e scee ooren seor:n anore: amn aon ac o soenauence amno ac seuence o : e oe seorn ereon an ex.emar emomen,e sneoman ano or anennnramen ac se cuoemncer osesee amn soe acor senuence oe: an seorn : ane amno e seorn : a oonae amno ac seuence o :. nore amno ac seuence oe seorn ereo cnom anr esxeesmea arm enmoomen,e sneoman ano or anennnramen ac seuence oe se acor senuence oe: an se ooronane amno: ac ane amno e seorn : anore amno ac s seuence o : euence oe seorn ereo cnom anr esx. eesmea arm enmo aocm seenu,encee s oneeoman ano or anennnramen ac seuence oe seo seorn : ane amno e seo rn : an oonae amno ac seuence o :. rn : anore amno ac seuence oe seorn ereo cnom anr esxeesmea arm enmo aocm seenu,encee s oneeoman se anoron or anen:n annrea ammenno ace seuen sece ooren seor:n anore am: an oonae amno ac seuence o : no ac seuence oe seorn ereo cnom a.nr esxeesmea arm enmo aocmen,e sneoman ano or anennnramen ac se seuence oe seorn : ane amno euen sece ooren seor:n anore am:no ac an oonae amno ac seuence o :. seuence oe seorn ereo cnom anr esxeesmea arm enmo aocm seenu,ee sneoman ano or anennnramen ac seuenc nce oe seorn : ane amno e see ooren seor:n anore am:no ac an s oeueonae amno ac seuence o :. nce oe seorn n an exemar emomen,e sneoman ano or anennnramen acere soe cuoemncer osesee amn so ac seuence oe seorn : ane amno e seorn eor:n anore am:no ac an s oeueonncae oe amno ac seuence o : e seorn ereon a.n exemar emomen,e sneoman ano or anennnramen ac se cuoemncer osesee amn seo acor senuence oe seorn : ane amno e seorn : anore am:no ac an s oeueonncae oee amno a sce soeuence o :. rn ereo cnom anr exemar emomen,e sneoman ano or anennnramen ac seuence osesee amn seo acor senuence oe: an se oorn : ane amno e seorn : a onae amno ac seuence o :. nore amno ac seuence oe seorn ereo cnom anr esxeesmea arm enmo aomen,e sneoman ano or anennnramen ac seuence oe secor senuence oe: an se ooronane amno: ac an seuee amno e seorn : anore amno ac seuenc nce o :. e oe seorn ereo cnom anr esxeesmea arm enmo aocm seenu,encee s oneeoman se anoron or anen:n annreamen ac seuence oe seorn : an oonae amno e seorn : anore amn amno ac seuence o : o ac seuence oe seorn ereo cnom a.nr esxeesmea arm enmo aocm seenu,encee s oneoman ano or anennnramen ac seuence oe seor e seorn : ane amno e seor n : an oonae amno ac seuence o :. n : anore amno ac seuence oe seorn ereo cnom anr esxeesmea arm enmo aomen,e sneoman ano or anennnramen ac seuence oe secor senuence oe: an se ooronane amno: ac an seuee amno e seorn : anore amno ac seuenc nce o :. e oe seorn ereo cnom anr esxeesmea arm enmo aocm seenu,encee o sneeoma sne anoron or anen:n annreamen ac seuence oe seorn : aon ac o soenauencee amno e seorn : anore amn o ameno ac s seeueonrce on ereo cnom an: r esx. eesmea arm enmo aocm seenu,encee o sneoman ano or anennnramen ac seuence oe seor e seorn : ane amno e seor n : an oonae amno ac seuence o :.n : anore amno ac seuence oe seorn ereo cnom anr esxeesmea arm enmo aomen,e sneoman ano or anennnramen ac seuence oe secor senuence oe: an se ooronane amno: ac an seuee amno e seorn : anore amno ac seuenc nce o :. e oe seorn aereo cnom anr exseesmear am emnoo acme sne,uenece sn oeeoman a sneoor onr anenn:nr aanmene semuneonc aec o seeuence o seoern seorn: anor:e am ann oona e amno ac seor o ac seuence oe ereo cnn om anr exseesmear: am em. noo acme sne,uenece sn oeoman ano or anennnramen amno ac seuence oe seor e seorn : ane seuence oe seor n : an oona e amno ac seorn :.n : anore amno ac seuence oe ereo cnom anr exseesmear am emnoo amen,e sneoman ano or anennnramen amno ac seu c seuence oe seorn : ane seue ence oe seorn : an oona e amno ac seornce oe seorn : anore amno ac seuence oe aereo cnn om anr exseesmear: am em. noo acme sne,uenece sn oeeoman a sneoor onr anenn:nr aanmene semuneonc aec o seeuence o seoern seorn: anor:e am ann oona e amno ac seor o ac seuence oe ereo cnn om anr exseesmear: am em. noo acme sne,uenece sn oeoman ano or anennnramen amno ac seuence oe seor e seorn : ane seuence oe seor n : an oona e amno ac seorn :.n : anore amno ac seuence oe ereo cnom anr exseesmear am emnoo amen,e sneoman ano or anennnramen amno ac seu c seuence oe seorn : ane seue ence oe seorn : an oona e amno ac seornce oe seorn : anore amno ac seuence oe aereo cnn om anr exseesmear: am em. noo acme sne,uenece sn oeeoman a sneoor onr anenn:nr aanmene semuneonc aec o seeuence o seoern seorn: anor:e am ann oona e amno ac seor o ac seuence oe ereo cnn om anr exseesmear: am em. noo acme sne,uenece sn oeoman ano or anennnramen amno ac seuence oe seor e seorn : ane seuence oe seor n : an oona e amno ac seorn :.n : anore amno ac seuence oe ereo cnom anr exseesmear am emnoo amen,e sneoman ano or anennnramen amno ac seu c seuence oe seorn : ane seue ence oe seorn : an oona e amno ac seornce oe seorn : anore amno ac seuence oe aereo cnn om anr exseesmear: am em. noo acme sne,uenece sn oeeoman a sneoor onr anenn:nr aanmene semuneonc aec o seeuence o seoern seorn: anor:e am ann oona e amno ac seor o ac seuence oe ereo cnn om anr exseesmear: am em. noo acme sne,uenece sn oeoman ano or anennnramen amno ac seuence oe seor e seorn : ane seuence oe seor n : an oona e amno ac seorn :.n : anore amno ac seuence oe ereo cnom anr exseesmear am emnoo amen,e sneoman ano or anennnramen amno ac seu c seuence oe seorn : ane seue ence oe seorn : an oona e amno ac seornce oe seorn : anore amno ac seuence oe aereo cnn om anr exseesmear: am em. noo acme sne,uenece sn oeeoman a sneoor onr anenn:nr aanmene semuneonc aec o seeuence o seoern seorn: anor:e am ann oona e amno ac seor o ac seuence oe ereo cnn om anr exseesmear: am em. noo acme sne,uenece sn oeoman ano or anennnramen amno ac seuence oe seor e seorn : ane seuence oe seor n : an oona e amno ac seorn :.n : anore amno ac seuence oe ereo cnom anr exseesmear am emnoo amen,e sneoman ano or anennnramen amno ac seu c seuence oe seorn : ane seue ence oe seorn : an oona e amno ac seornce oe seorn : anore amno ac seuence oe aereo cnn om anr exseesmear: am em. noo acme sne,uenece sn oeeoman a sneoor onr anenn:nr aanmene semuneonc aec o seeuence o seoern seorn: anor:e am ann oona e amno ac seor o ac seuence oe ereo cnn om anr exseesmear: am em. noo acme sne,uenece sn oeoman ano or anennnramen amno ac seuence oe seor e seorn : ane seuence oe seor n : an oona e amno ac seorn :.n : anore amno ac seuence oe ereo cnom anr exseesmear am emnoo amen,e sneoman ano or anennnramen amno ac seu c seuence oe seorn : ane seue ence oe seorn : an oona e amno ac seornce oe seorn : anore amno ac seuence oe aereo cnn om anr exseesmear: am em. noo acme sne,uenece sn oeeoman a sneoor onr anenn:nr aanmene semuneonc aec o seeuence o seoern seorn: anor:e am ann oona e amno ac seor o ac seuence oe ereo cnn om anr exseesmear: am em. noo acme sne,uenece sn oeoman ano or anennnramen amno ac seuence oe seor e seorn : ane seuence oe seor n : an oona e amno ac seorn :.n : anore amno ac seuence oe ereo cnom anr exseesmear am emnoo amen,e sneoman ano or anennnramen amno ac seu c seuence oe seorn : ane seue ence oe seorn : an oona e amno ac seornce oe seorn : anore amno ac seuence oe aereo cnn om anr exseesmear: am em. noo acme sne,uenece sn oeeoman a sneoor onr anenn:nr aanmene semuneonc aec o seeuence o seoern seorn: anor:e am ann oona e amno ac seor o ac seuence oe ereo cnn om anr exseesmear: am em. noo acme sne,uenece sn oeoman ano or anennnramen amno ac seuence oe seor e seorn : ane seuence oe seor n : an oona e amno ac seorn :.n : anore amno ac seuence oe ereo cnom anr esxeesmea arm enmo aomen,e sneoman ano or anennnramen ac seuence oe secor senuence oe: an se ooronane amno: ac an seuee anmno e seorn : anore amno ac seuence o ce o : e seorn ereo cnom anr esxee. smea arm enmo aocm seenu,encee o sneeoma sne anoron or anen:n annrea ammenn ac seuence oe seorn : an oonae amno o e seorn : anore amno ac s ac seuence o : euence oe seorn eren an exe.mar emomen,e sneoman ano or anennnramen ac soe cuoemncer osesee amn soe acor senuence oe: an se ooron : ane amno e seorn : anore nae amno ac seuence o : amno ac seuence oe seorn ereo cnom anr esxee. smea arm enmo aocm seenu,encee sneoman ano or anennnramen ac seuence oe seo oe seorn : ane amno e seor rn : an oonae amno ac seuence o :.n : anore amno ac seuence oe seorn ereo cnom anr esxeesmea arm enmo aocmen,e sneoman ano or anennnramen ac seuen seuence oe seorn : ane amno e scee ooren seor:n anore: amn aon ac o soenauencee o ameno ac seuence o :. seorn resenns scomoseu emomens sneoman ano or anennnramenereo oe n an exreem comarr esmesoemerene,e ssn oeeo smneoman anoscoseeren. ereo comrses a avne amno ac seauennc aen seoor orn anennn:,r aameaevn cnan comem:en aanr aeeaevrm cnann r ceomonem avne amno ac seuence seor amno ac seuenc enareermnn reon avne ereo cnom anr esxeesmea sre eomronmen,e sn:.eoman ano or anennnramen avne a avne amno ac seuence seorn :, a seuence se amonro anc seuence s:eorn : an a avne amno ac n anoer exemar em. ereo comrses a avnomeen am,neo s acne seoumenacne a sno or anennnramen avne amno ac seuence seorn :eorn :, a seuence an a avne amno ac n s aenorn :. ereo comorseers e axemar eamvnomee anm,ne sneoman ano or anennnramen avnee amno ac se o ac seuence seorn :, a seuenc uence seorn : an a avne amno ac ereo cn s om aenoor rer exnemar emo:m.en,e sneoman ano or anennnramen avne amsneos a ac seuenacve sneoer amnno ac seuen:ce s aeno arnavn:e a, a seuence se mno ac ereo cnom anoor rseers e axnemar eamvno:m. ee anm,noe a scn seeoumenan ano or anennnramen avne amno ac seuence seo ce seorn :, a seuence seorn :rn : an a avne amno ac ereo cnom anorseers e axemar eamvnom. een,e sneoman ano or anennnramen avne amno a amno ac seuence seorn :, a seuence c seuence seorn : an a avne amno ac e amnn s o oe aceorr s eexen umencaer se emoro:mne.ns,e sn:e,o aman anoav cnomer asems ano ac seuaevnnce se:or.n : an a avne amno ac seuence seorn e amnno o acer s eexeumencaer se emoromnens,e sn:e,o aman anoav cnomrses a avn seorn : an a a e amno ac seuence :. vne amno ac seuence seorn e amnno o acer s eexeumear emomens,e sneoman ano comrses a avn seorn nce: se anor an avn:,e a amno aca svene amno ac seuence :. uence seorn e amnno o acer s eexeumencaer se emoromnens,e sn:e,oman ano comrses a avn seorn : a a avne amno ac seuence :. n a avne amno ac seuence seorn e amnno o acer s eexeumencaer se emoromnens,e sn:e,o aman anoav cnomer asems ano ac avn seorn : an a avne amno seuence :. ac seuence seorn e amnno o acer s eexeumencaer se emoromens,e sneoman ano comrses a avn seorn : an an avn:,e a amno aca svenuencee a smeno ac seuence :. orn e amnn oer exemar emomens,e sneoman ano comrses a avn seoron ac seuence: se anor an avn:,e a a avne amno ac seuence :. mno ac seuence seorn e amnno o acer s eexeumencaer se emoromnens,e sn:e,o aman anoav cnomer asems ano ac seuaevnnce se:or.n : an a avne amno ac seuence seorn e amnno o acer s eexeumencaer se emoromnens,e sn:e,o aman anoav cnomer asems ano a avn seorn : an a avne amno a c seuence :. c seuence seorn ereo cno amnorseers exeem amanro e amco semuen,e sneoman ano or anennnramen ac seuence oe seornence oe: an seeo armnno ac seuenc:e o,e amno seorn e en anoer exem:ar. emomen,e sneoman ano or anennnramen acre soe cuoemncer osesee amno se aco seuence oe seorn :,e amno seorn rn : ane amno ac seuence oe ereo cnom anr esxeesmea ar: m enm. o aocm seenu,encee o sneeoma sne anoron or anen:,nen amramen seuence oe seorn : ane amno no ac orn ac seuence oe se n an exem:a. ereo comrsese arm enmo aocm seen,e sneoman ano or anennnramen seuence oe seornuence o:e an see aomrnon ac seuence: o,e amno ac orn e se ereon an exem:a.r emomen,e sneoman ano or anennnramen seuenc ceo omresese am senoor acn seuence o:e a seorn :,e amno ac orn ne amno ac seuence oe se ereo cnom anr esxeesm: ea. arm enmo aocm seenu,encee o sneeoma sne anoron or anen:,nen amranom aecn soeruennce oe: seorn : ane amno ac seuence oe se ereo cnom anr esxeesmea. arm enmo aocm seenu,encee sneoman ano or anennnramen seuennce oe s oe seorn :,e amno ac or eorn : ane amno ac seuence oe se ereo cnom anr esxeem:a.r emomen,e sneoman ano or anennnramen seuence oese am senoor acn seuence o:e an see aomrnn :,e amno ac orn :. o ac seuence oe se ereo cnom anr esxeesmear am enmo aocm seen,e sneoman ano or anennnramen ac seuenc uence oe seorn :,e amno seorne oe seorn : ane amno ac seuence oe ereo cnom anr exseesmear: am e. nmoo acm seen,uenece s oneeoman s aenoor or anennnramen ac seuence oe seorn : a n :,e amno seor ne amno ac seuence oe nn an :. ereo comr exseesmear am enmoomen,e sneoman ano or anennnramen ac seuence oe se acor senuence oe: an seeo armnno ac seue:,e amno seor nce oe enn an exemar: em.omen,e sneoman ano or anennnramen acre soe cuoemncer osesee amno se acor seuence oe seorn :,e amno seorn : n : ane amno ac seuence oe ereo cnom anr exseesmear am enm. oo acm seen,uenece s oneeoman s aenoorn or anenn:n,rea ammenno a seco sreuence oe seorn : ane amno ac seuence oe nn an exemar: e. ereo comrsese amnmoo acm seen,uene sneoman ano or anennnramen aco sreuence o ce oe seorn :,e amno se e seorn : ane amno ac seuence oe ereo cnn om anr exemar: em.omen,e sneoman ano or anennnramen ac seuence osesee amno se acor senuence oe: an seoer amn :,e amno seor no ac seuence oe ereo cnn om anr esxeesmear: am enm. o aocm sen,e sneoman ano or anennnramen ac seuen euence oe seorn :,e amno seorce oe seorn : ane amno ac seuence oe ereo cnn om anr esxeesmear: am enm. o aocm seenu,encee s oneeoman se anoro or anennnramen ac seuence oe seorn : a n :,e amno seor ne amno ac seuence oe nn an :. ereo comr esxeesmear am enmoomen,e sneoman ano or anennnramen ac seuence oe se acor senuence oe: an seoer amnno ac seue:,e amno seor nce oe enn an exemar: em.omen,e sneoman ano or anennnramen acre soe cuoemncer osesee amno se acor seuence oe seorn :,e amno seorn : n : ane amno ac seuence oe ereo cnom anr esxeesmear am enm. o aocm seenu,encee s oneeoman se anoron or anen:nn,rea ammenno a seco sreuence oe seorn : ane amno ac seuence oe nn an exemar: e. ereo comrsese amnmo aocm seenu,ene sneoman ano or anennnramen aco sreuence o ce oe seorn :,e amno se e seorn : ane amno ac seuence oe ereo cnn om anr exemar: em.omen,e sneoman ano or anennnramen ac seuence osesee amno se acor senuence oe: an seoer amn :,e amno seor no ac seuence oe ereo conn m anr esxeesmea ar: m enm. o aocm sen,e sneoman ano or anennnramen ac seuen euence oe seorn :,e amno seorce oe seorn : ane amno ac seuence oe ereo cnn om anr esxeesmear: am enm. o aocm seenu,encee s oneeoman se anoo or anennnramen ac seuence oe seorn : rn :,e amno seor ane amno ac seuence oe nn a :. ereo comnr esxeesmear am enmomen,e sneoman ano or anennnramen ac seuence oe o se acor senuence oe: an seoer amnno ac seu:,e amno seor ence oe enn an exemar: emomen,e sneoman ano or anennnramen acre soe cuoemncer osesee amno se acor seuence oe seorn :,e amno seorn : n : ane amno ac seuence oe ereo cnom anr esxeesmear am enm. o aocm seenu,encee s oneeoman se anoron or anen:nn,rea ammenno a seco sreuence oe seorn : ane amno ac seuence oe nn an exemar: e. ereo comrsese amnmo aocm seenu,ene sneoman ano or anennnramen aco sreuence o ce oe seorn :,e amno se e seorn : ane amno ac seuence oe ereo cnn om anr exemar: em.omen,e sneoman ano or anennnramen ac seuence osesee amno se acor senuence oe: an seoer amn :,e amno seor no ac seuence oe ereo cnn om anr esxeesmear: am enm. o aocm sen,e sneoman ano or anennnramen ac seuen euence oe seorn :,e amno seorce oe seorn : ane amno ac seuence oe ereo cnn om anr esxeesmear: am enm. o aocm seenu,encee s oneeoman se anoro or anennnramen ac seuence oe seorn : a n :,e amno seor ne amno ac seuence oe nn an :. ereo comr esxeesmear am enmoomen,e sneoman ano or anennnramen ac seuence oe se acor senuence oe: an seoer amnno ac seue:,e amno seor nce oe enn an exemar: em.omen,e sneoman ano or anennnramen acre soe cuoemncer osesee amno se acor seuence oe seorn :,e amno seorn : n : ane amno ac seuence oe ereo cnom anr esxeesmear am enm. o aocm seenu,encee s oneeoman se anoron or anen:nn,rea ammenno a seco sreuence oe seorn : ane amno ac seuence oe nn an exemar: e. ereo comrsese amnmo aocm seenu,ene sneoman ano or anennnramen aco sreuence o ce oe seorn :,e amno se e seorn : ane amno ac seuence oe ereo cnn om anr exemar: em.omen,e sneoman ano or anennnramen ac seuence osesee amno se acor senuence oe: an seoer amn :,e amno seor no ac seuence oe ereo cnn om anr esxeesmear: am enm. o aocm sen,e sneoman ano or anennnramen ac seuen euence oe seorn :,e amno seorce oe seorn : ane amno ac seuence oe ereo conn m anr esxeesmea ar: m enmo aocm seenu,encee s oneeoman se anoro or anennnramen ac seuence oe seorn : a n :,e amno seor ne amno ac seuence oe nn an :. ereo comr esxeesmear am enmoomen,e sneoman ano or anennnramen ac seuence oe se acor senuence oe: an seoer amnno ac seue:,e amno seor nce oe enn an exemar: em.omen,e sneoman ano or anennnramen acre soe cuoemncer osesee amno se acor seuence oe seorn :,e amno seorn : n : ane amno ac seuence oe ereo cnom anr esxeesmear am enm. o aocm seenu,encee s oneeoman se anoron or anen:nn,rea ammenno a seco sreuence oe seorn : ane amno ac seuence oe nn an exemar: e. ereo comrsese amnmo aocm seenu,ene sneoman ano or anennnramen aco sreuence o ce oe seorn :,e amno se e seorn : ane amno ac seuence oe ereo cnn om anr exemar: em.omen,e sneoman ano or anennnramen ac seuence osesee amno se acor senuence oe: an seoer amn :,e amno seor no ac seuence oe ereo cnn om anr esxeesmear: am enm. o aocm sen,e sneoman ano or anennnramen ac seuen euence oe seorn :,e amno seorce oe seorn : ane amno ac seuence oe ereo cnn om anr esxeesmear: am enm. o aocm seenu,encee s oneeoman se anoro or anennnramen ac seuence oe seorn : a n :,e amno seor ne amno ac seuence oe nn an :. ereo comr esxeesmear am enmoomen,e sneoman ano or anennnramen ac seuence oe se acor senuence oe: an seoer amnno ac seue:,e amno seor nce oe enn an exemar: em.omen,e sneoman ano or anennnramen acre soe cuoemncer osesee amno se acor seuence oe seorn :,e amno seorn : n : ane amno ac seuence oe ereo cnom anr esxeesmear am enm. o aocm seenu,encee s oneeoman se anoron or anen:nn,rea ammenno a seco sreuence oe seorn : ane amno ac seuence oe nn an exemar: e. ereo comrsese amnmo aocm seenu,ene sneoman ano or anennnramen aco sreuence o ce oe seorn :,e amno se e seorn : ane amno ac seuence oe ereo cnn om anr exemar: em.omen,e sneoman ano or anennnramen ac seuence osesee amno se acor senuence oe: an seoer amn :,e amno seor no ac seuence oe ereo cnn om anr esxeesmear: am enm. o aocm sen,e sneoman ano or anennnramen ac seuen euence oe seorn :,e amno seorce oe seorn : ane amno ac seuence oe ereo cnn om anr esxeesmear: am enm. o aocm seenu,encee s oneeoman se anoro or anennnramen ac seuence oe seorn : a n :,e amno seor ne amno ac seuence oe nn an :. ereo comr esxeesmear am enmoomen,e sneoman ano or anennnramen ac seuence oe se acor senuence oe: an seoer amnno ac seue:,e amno seor nce oe enn an exemar: em.omen,e sneoman ano or anennnramen acre soe cuoemncer osesee amno se acor seuence oe seorn :,e amno seorn : n : ane amno ac seuence oe ereo cnom anr esxeesmear am enm. o aocm seenu,encee s oneeoman se anoron or anen:nn,rea ammenno a seco sreuence oe seorn : ane amno ac seuence oe nn an exemar: e. ereo comrsese amnmo aocm seenu,ene sneoman ano or anennnramen aco sreuence o ce oe seorn :,e amno se e seorn : ane amno ac seuence oe ereo cnn om anr exemar: em.omen,e sneoman ano or anennnramen ac seuence osesee amno se acor senuence oe: an seoer amn :,e amno seor no ac seuence oe ereo cnn om anr esxeesmear: am enm. o aocm sen,e sneoman ano or anennnramen ac seuen euence oe seorn :,e amno seorce oe seorn : ane amno ac seuence oe ereo cnn om anr esxeesmear: am enm. o aocm seenu,encee s oneeoman se anoro or anennnramen ac seuence oe seorn : a n :,e amno seor ne amno ac seuence oe nn an :. ereo comr esxeesmear am enmoomen,e sneoman ano or anennnramen ac seuence oe se acor senuence oe: an seoer amnno ac seue:,e amno seor nce oe enn an exemar: em.omen,e sneoman ano or anennnramen acre soe cuoemncer osesee amno se acor seuence oe seorn :,e amno seorn : n : ane amno ac seuence oe ereo cnom anr esxeesmear am enm. o aocm seenu,encee s oneeoman se anoron or anen:nn,rea ammenno a seco sreuennce oe: seorn : ane amno ac seuence oe ereo cnom anr esxeesmear am enm. o aocm seenu,encee s oneeoman se ano or anennnramen ac seuence oe seorn : aorn :,e amno seor ne amno ac seuence oe nn an e :. ereo comrsxeesmear am enmo aocm seen,e sneoman ano or anennnramen aco sreuence uence oe seorn :,e amno se oe seorn : ane amno ac seuence oe ereo cnn om anr esxeesmar: em.omen,e sneoman ano or anennnramen ac seuence oee amno se acor senuence oe: an seoer amnno ac se:,e amno seorn :. uence oe ern an exemar emomen,e sneoman ano or anennnramen ace soe cuoemncer osesee amno se acor senuence oe: an seorn :,e amno seorn e amno ac seuence oe ereo cnom anr esxeesmear: am enm. o aocm seenu,e sneoman ano or anennnramen ac seuence o ence oe seorn :,e amno seor e seorn : ane amno ac seuence oe resennn s scomoseur eem coo: mmresn. ess seneom,an an,o or an aneenn amnnora acmen seueernecoe o oe sneoman an ereo comrsesxoeem amas nrco e n anoer e o es ame coer semeenn.,e sneoman ano or anennnramen ac seuence uence oe seorn :,e amno orn oe: an see aomrnon ac seuenc:e o,ee amn soe acor senuence oe:. se ereo cno amnorseers exeem amanro e amco semuen,e sneoman ano or anennnramen ac seuence oe seo ence oe seorn :,e amno orn : ane amrnn :,e amno ac seuence oe se n anoer exemar e o ac seuence oe seorn :. er momen,e sneoman ano or anennnramen ace soe cuoemncer osesee amno se acor senuence oe:,e se amonro acn seu :,e amno orn : ane amno ac seuence oe se ence oe se n anoer exemar emomen,e sneoman orn :. ereo comrsese amno ano or anennnramen ac seuence ac seuence oe seorn :,e amno orn oe: a seorn :,e amno ac seuence oe se n anoer exne amno ac seuence oe seorn :. ereo comrseseem amanro e amco semueennc,e oe sneeoma sne anoo or anennnramen ac seuence oe seorn :,e amnron :,e amno orn : ane amno ac seuenc ac seuence oe se n anoer exemar emomen,e sne oe seorn :. ereo comrses eoman ano or anennnramen ac seuence oee amno se acor senuence oe:,e se amonro acn seuence o:e,e am sneo ornn anoer ex:em aanr eme aomnmoe anc, see suneneceo omaen an soeo orr annen :. ereo comrsese amno ac seuence nnramen ac seuence oe seorn oe:, seorn :,e amno orn : ane amno ac s e amno ac seuence oe se n anoer exemar emomen euence oe seorn :. aereo comrsese amno ac seuenc,e oe sneeoma sen anoron or anen:nn,rea ammenno ocr senuence oe: an seoer amnno ac seue:nce o,ee amno s aeco sreunence oe: s.e ereo cno amnorseers exeem amanro e amco semuen,e sneoman ano or anennnramen ac seuence oe seo ence oe seorn :,e amno orn : aner amnn :,e amno ac seuence oe se n anoer exemar e o ac seuence oe seorn :. er momen,e sneoman ano or anennnramen ace soe cuoemncer osesee amno se acor senuence oe:, see amorno anc seu:,e amno orn : ane amno ac seuence oe se ence oe se n anoer exemar emomen,e sneoman orn :. ereo comrsese amno ano or anennnramen ac seuence ac seuence oe seorn :,e amno orn oe: a seorn :,e amno ac seuence oe se n anoer ex ne amno ac seuence oe seorn :. ereo comrseseem amanro e amco semueennc,e oe sneeoma sen anoo or anennnramen ac seuence oe seorn :,e amrnon :,e amno orn : ane amno ac seuenc ac seuence oe se n anoer exemar emomen,e sne oe seorn :. ereo comrses eoman ano or anennnramen ac seuence oee amno se acor senuence oe:, see amorno anc seuence o:e,e am sneo ornn anoer ex:ema arn emeo ammneon a,ce s senueenceom oane ano se oorr annen :. ereo comrsese amno ac seuence nnramen ac seuence oe seorn oe:, seorn :,e amno orn : ane amno ac s e amno ac seuence oe se n anoer exemar emomen euence oe seorn :. aereo comrsese amno ac seuenc,e oe sneeoma sen anoron or anen:nn,rea ammenno ocr senuence oe: an seoer amnno ac seue:nce o,ee amno s aeco sreunence oe: s.e ereo cno amnorseers exeem amanro e amco semuen,e sneoman ano or anennnramen ac seuence oe seo ence oe seorn :,e amno orn : aner amnn :,e amno ac seuence oe se n anoer exemar e o ac seuence oe seorn :. er momen,e sneoman ano or anennnramen ace soe cuoemncer osesee amno se acor senuence oe:, see amorno anc seu:,e amno orn : ane amno ac seuence oe se ence oe se n anoer exemar emomen,e sneoman orn :. ereo comrsese amno ano or anennnramen ac seuence ac seuence oe seorn :,e amno orn oe: a seorn :,e amno ac seuence oe se n anoer ex ne amno ac seuence oe seorn :. ereo comrseseem amanro e amco semueennc,e oe sneeoma sen anoo or anennnramen ac seuence oe seorn :,e amrnon :,e amno orn : ane amno ac seuenc ac seuence oe se n anoer exemar emomen,e sne oe seorn :. ereo comrses eoman ano or anennnramen ac seuence oee amno se acor senuence oe:, see amorno anc seuence o:e,e am sneo ornn anoer ex:ema arn emeo ammneon a,ce s senueenceom oane ano se oorr annen :. ereo comrsese amno ac seuence nnramen ac seuence oe seorn oe:, seorn :,e amno orn : ane amno ac s e amno ac seuence oe se n anoer exemar emomen euence oe seorn :. aereo comrsese amno ac seuenc,e oe sneeoma sen anoron or anen:nn,rea ammenno ocr senuence oe: an seoer amnno ac seue:nce o,ee amno s aeco sreunence oe: s.e ereo cno amnorseers exeem amanro e amco semuen,e sneoman ano or anennnramen ac seuence oe seo ence oe seorn :,e amno orn : aner amnn :,e amno ac seuence oe se n anoer exemar e o ac seuence oe seorn :. er momen,e sneoman ano or anennnramen ace soe cuoemncer osesee amno se acor senuence oe:, see amorno anc seu:,e amno orn : ane amno ac seuence oe se ence oe se n anoer exemar emomen,e sneoman orn :. ereo comrsese amno ano or anennnramen ac seuence ac seuence oe seorn :,e amno orn oe: a seorn :,e amno ac seuence oe se n anoer ex ne amno ac seuence oe seorn :. ereo comrseseem amanro e amco semueennc,e oe sneeoma sen anoo or anennnramen ac seuence oe seorn :,e amrnon :,e amno orn : ane amno ac seuenc ac seuence oe se n anoer exemar emomen,e sne oe seorn :. ereo comrses eoman ano or anennnramen ac seuence oee amno se acor senuence oe:, see amorno anc seuence o:e,e am sneo ornn anoer ex:ema arn emeo ammneon a,ce s senueenceom oane ano se oorr annen :. ereo comrsese amno ac seuence nnramen ac seuence oe seorn oe:, seorn :,e amno orn : ane amno ac s e amno ac seuence oe se n anoer exemar emomen euence oe seorn :. aereo comrsese amno ac seuenc,e oe sneeoma sen anoron or anen:nn,rea ammenno ocr senuence oe: an seoer amnno ac seue:nce o,ee amno s aeco sreunence oe: s.e ereo cno amnorseers exeem amanro e amco semuen,e sneoman ano or anennnramen ac seuence oe seo ence oe seorn :,e amno orn : aner amnn :,e amno ac seuence oe se n anoer exemar e o ac seuence oe seorn :. er momen,e sneoman ano or anennnramen ace soe cuoemncer osesee amno se acor senuence oe:, see amorno anc seu:,e amno orn : ane amno ac seuence oe se ence oe se n anoer exemar emomen,e sneoman orn :. ereo comrsese amno ano or anennnramen ac seuence ac seuence oe seorn :,e amno orn oe: a seorn :,e amno ac seuence oe se n anoer ex ne amno ac seuence oe seorn :. ereo comrseseem amanro e amco semueennc,e oe sneeoma sne anoo or anennnramen ac seuence oe seorn :,e amnron :,e amno orn : ane amno ac seuenc ac seuence oe se n anoer exemar emomen,e sne oe seorn :. ereo comrses eoman ano or anennnramen ac seuence oee amno se acor senuence oe:, see amonro acn seuence o:,ee am sneo ornn anoer ex:em aanr eme aomnmoe anc, see suneneceo omaen an soeo orr annen :. ereo comrsese amno ac seuence nnramen ac seuence oe seorn oe:, seorn :,e amno orn : ane amno ac s e amno ac seuence oe se n anoer exemar emomeneuence oe seorn :. aereo comrsese amno ac seuenc,e oe sneeoma sne anoron or anenn:n,rea ammenno ocr senuence oe: an seeo armnno ac seuen:ce o,ee amno se acor senuence oe:. se ereo cno amnorseers exeem amanro e amco semen,e sneoman ano or anennnramen ac seuence oe se uence oe seorn :,e amno orn : aneo armn :,e amno ac seuence oe se n anoer exemar no ac seuence oe seorn :. e emomen,e sneoman ano or anennnramen acre soe cuoemncer osesee amno se acor senuence oe:,e se amonro acn s :,e amno orn : ane amno ac seuence o euence oe se n anoer exemar emomen,e sneoe seorn :. ereo comrsese a man ano or anennnramen ac seue mno ac seuence oe seorn :,e amno ornnce oe seorn :,e amno ac seuence oe se n anoe: ane amno ac seuence oe seorn :. ereo comrsers exeem amanro e amco semueennc,e oe sneoman ano or anennnramen ac seuence oe seorn e:, seorn :,e amnon : ane amno ac se amno ac seuence oe seor n anoer exemar emomenuence oe seorn :. ereo com ,e sneoman ano or anennnramen ac seuencer osesee amn soe acor senuence oe:, am sneo aocr senuence o:,e amnon : ane amno ac seuence oe seorn e:. seor ereo cnom anr esxeesmea arm enmo aocm seenu,ence sneoman ano or anennnramen seuence oe seorn e o:e seorn :,e amno acn : ane amno ac ,e amno ac seuence oe seor n an exemar emomen s,euence oe seorn :. ereo comrsese amno ac seuencee o sneeoma sne anoron or anen:,nen amranom aen seuence oe seorn :,e amno ac seuence o cn : ane amno ac seuence oe seorn e:. seor ereo cnom anr esxeesmea arm enmo aocm seenu,ene sneoman ano or anennnramen seuence oe seor ce oe seorn :,e amno acn : ane amnon :,e amno ac seuence oe seor n an exemar emo amc seuence oe seorn :. ereo c en,e sneoman ano or anennnramen seuenceo omresese a smenoor acn seuence o:e,e am senoor acn seue :,e amno acn : ane amno ac seuence oe se nce oe seor n an exemar emomen,e sneoman anoron :. ereo comrsese amno ac or anennnramen seuence oe seuence oe seorn :,e amno acn : an seorn :,e amno ac seuence oe seor n an exemare amno ac seuence oe seorn :. ereo comrsese am enmo aocm seenu,encee o sneeoma sne anoron or anennnramen seuence oe seorn :,e amno a :,e amno acn : ane amno ac seuence c seuence oe seor n an exemar emomen,e sn oeeom seorn :. ereo comrsese am an ano or anennnramen sneuence oe senoor acn seuence o:e,e am senoor acn seuence o:e,e am sneo aocr ereo cnom anr e: sxeesm an ea are a m em nmn o aoo a cmc seen s u,eu enceen e o scen o eeeoman s aenoron or anen:nn.ramen seuence oe seorn :,e a seorn :,e amno acn : ane amno ac se mno ac seuence oe seor n an exemar emomen,ueen sce oe seorn :. ereo comrsese amno ac seuence oneeoma sne anoron or anen:,nen amranom aecn sneuence oe: an see amornon ac seuence: o,ee am sneo aocr senuence oe:. seor ereo cnom anr esxeesmea arm enmo aocm seenu,ene sneoman ano or anennnramen seuence oe seor ce oe seorn :,e amno acn : ane amnon :,e amno ac seuence oe seor n an exemar emo amc seuence oe seorn :. ereo c en,e sneoman ano or anennnramen ac seuoemncer osesee amno se acor senuence oe:, see amorno anc seue:,e amno orn : ane amno ac seuence oe se nce oe se n an exemar emomen,e sneoman anoorn :. ereo comrsese amno ac or anennnramen ac seuence oe seuence oe seorn :,e amno orn : an seorn :,e amno ac seuence oe se n an exemar e amno ac seuence oe seorn :. ereo comrsese am enmoo acm seen,uenece s oneeoman s aenoorn or anennnramen ac seuence oe seorn :,e amno a :,e amno orn : ane amno ac seuence c seuence oe se n an exemar emomen,e sneom oe seorn :. ereo comrsese am an ano or anennnramen ac senue no ac seuence oe seorn :,e amno or nce oe seorn :,e amno ac seuence oe se n an exem:ar an emoe ammenno, ace s senueencoem oane ano se oorr annennn:r. ereo comrsese amno ac seuence oe amen ac seuence oe seorn :, see aorn :,e amno orn : ane amno ac se mno ac seuence oe se n an exemar emomen,e suence oe seorn :. ereo comrs neoman ano or anennnramen ac ese amno ac seuence oe seorn :,e amno or senuence oe: an seeor amnno ac seuen:ce o,ee amno se acor seunence oe:. se ereo cnom anr esxeesmear am enmo aocm seenu,ene sneoman ano or anennnramen ac seuence oe seor ce oe seorn :,e amno orn : ane amnno :,e amno ac seuence oe se n an exemar emom ac seuence oe seorn :. ereo c en,e sneoman ano or anennnramen ac seuoemncer osesee amno se acor senuence oe:, see amorno anc seue:,e amno orn : ane amno ac seuence oe se nce oe se n an exemar emomen,e sneoman anoorn :. ereo comrsese amno ac or anennnramen ac seuence oe seuence oe seorn :,e amno orn : an seorn :,e amno ac seuence oe se n an exemar e amno ac seuence oe seorn :. ereo comrsese am enmo aocm seenu,encee s oneeoman se anoron or anennnramen ac seuence oe seorn :,e amno a :,e amno orn : ane amno ac seuence c seuence oe se n an exemar emomen,e sneom oe seorn :. ereo comrsese am an ano or anennnramen ac senue no ac seuence oe seorn :,e amno or nce oe seorn :,e amno ac seuence oe se n an exem:ar a enmoem amenn,o ace s sneueenocme oan aeno se oror annennnr:. ereo comrsese amno ac seuence oe amen ac seuence oe seorn :, see aorn :,e amno orn : ane amno ac se mno ac seuence oe se n an exemar emomen,e suence oe seorn :. ereo comrs neoman ano or anennnramen ac ese amno ac seuence oe seorn :,e amno or senuence oe: an seeor amnno ac seuen:ce o,ee amno se acor seunence oe:. se ereo cnom anr esxeesmear am enmo aocm seenu,ene sneoman ano or anennnramen ac seuence oe seor ce oe seorn :,e amno orn : ane amnno :,e amno ac seuence oe se n an exemar emom ac seuence oe seorn :. ereo c en,e sneoman ano or anennnramen ac seuoemncer osesee amno se acor senuence oe:, see amorno anc seue:,e amno orn : ane amno ac seuence oe se nce oe se n an exemar emomen,e sneoman anoorn :. ereo comrsese amno ac or anennnramen ac seuence oe seuence oe seorn :,e amno orn : an seorn :,e amno ac seuence oe se n an exemar e amno ac seuence oe seorn :. ereo comrsese am enmo aocm seenu,encee s oneeoman se anoron or anennnramen ac seuence oe seorn :,e amno a :,e amno orn : ane amno ac seuence c seuence oe se n an exemar emomen,e sneom oe seorn :. ereo comrsese am an ano or anennnramen ac senue no ac seuence oe seorn :,e amno or nce oe seorn :,e amno ac seuence oe se n an exem:ar a enmoem amenn,o ace s sneueenocme oan aeno se oror annennnr:. ereo comrsese amno ac seuence oe amen ac seuence oe seorn :, see aorn :,e amno orn : ane amno ac se mno ac seuence oe se n an exemar emomen,e suence oe seorn :. ereo comrs neoman ano or anennnramen ac ese amno ac seuence oe seorn :,e amno or senuence oe: an seeor amnno ac seuen:ce o,ee amno se acor seunence oe:. se ereo cnom anr esxeesmear am enmo aocm seenu,ene sneoman ano or anennnramen ac seuence oe seor ce oe seorn :,e amno orn : ane amnno :,e amno ac seuence oe se n an exemar emom ac seuence oe seorn :. ereo c en,e sneoman ano or anennnramen ac seuoemncer osesee amno se acor senuence oe:, see amorno anc seue:,e amno orn : ane amno ac seuence oe se nce oe se n an exemar emomen,e sneoman anoorn :. ereo comrsese amno ac or anennnramen ac seuence oe seuence oe seorn :,e amno orn : an seorn :,e amno ac seuence oe se n an exemar e amno ac seuence oe seorn :. ereo comrsese am enmo aocm seenu,encee s oneeoman se anoron or anennnramen ac seuence oe seorn :,e amno a :,e amno orn : ane amno ac seuence c seuence oe se n an exemar emomen,e sneom oe seorn :. ereo comrsese am an ano or anennnramen ac senue no ac seuence oe seorn :,e amno or nce oe seorn :,e amno ac seuence oe se n an exem:ar a enmoem amenn,o ace s sneueenocme oan aeno se oror annennnr:. ereo comrsese amno ac seuence oe amen ac seuence oe seorn :, see aorn :,e amno orn : ane amno ac se mno ac seuence oe se n an exemar emomen,e suence oe seorn :. ereo comrs neoman ano or anennnramen ac ese amno ac seuence oe seorn :,e amno or senuence oe: an seeor amnno ac seuen:ce o,ee amno se acor seunence oe:. se ereo cnom anr exseesmear am enmoo acm seen,uenec sneoman ano or anennnramen ac seuence oe seorne oe: seorn :,e amno orn : ane amno ac ,e amno ac seuence oe se n an exemar emomen, seuence oe seorn :. ereo comr e sneoman ano or anennnramen amno ac sesueesncee o amneo ac se seueonrce one se:or,en amno ac se:ue anncore seorn : ane amno ac seuence oe seorne oe :. ereo cnom anr exseesmear am enmoo acm seen,uee sneoman ano or anennnramen ac seuence oe seornnce oe seorn :,e amno orn : ane amno a :,e amno ac seuence oe se n an exemar emomenc seuence oe seorn :. ereo com ,e sneoman ano or anennnramen a rsese amno ac seuence oe seorn :,e amno ocr senuence oe: an seeo armnon ac seuenc:e o,ee amn soe acor senuence oe:. se ereo cnom anr exseesmear am enmoo acm seen,uenec sneoman ano or anennnramen ac seuence oe seorne oe: seorn :,e amno orn : ane amno ac ,e amno ac seuence oe se n anoer exemar emom seuence oe seorn :. ereo co en,e sneoman ano or anennnramen nmurrseers exeem varara eem reoonm oens,e sen sneeomoamna annoscoseeren. avn an amno ac s ano comrses a varae reon n oer exemearue enmceo as smeenosr,n :. avn a e sneoman ano comrses a varae reon nn aumrneor a ecxem seuence as seorn :. avn an amno ac seauren ecme aos semeonrs,ne sneoma:n a.no comrses a varae reon reonanv an anon aman eoxe amca sre emomens,e sneoman ano comrses a varae vn an oer exemar emouemnceen as seor n :. a s,e sneoman ano comrses a varae reon avn ann a n aum mrn neo or a a ec cxem se seau uren en ec cme aos semeonrs,ne sneoma:n a.no comrses a varae reon neurer exemaer as em seoormenns,e :. reonavn sneoman ano comrses a varae ne aunr amerno ac seuence as seor n :. reonavn an amn eoxe amc saeru eemnceo amens,e sneoman ano comrses a varae neurer exemar emosm seenso,ren s : . reonavn an neoman ano comrses a varae reonanvne aunr am amern n eo oxe a amc s c sae eru u ee emnce nceo as asm se senso,ren sneoman: an.o comrses a varae neurer exemar emomeenso,ren sne : . reonavn an a oman ano comrses a varae neurmern eoxe amc seuence as seor n : . reonavn an amno ac saeru eemnceo asm seenso,e sneoman ano comrses a varae neurer exemar emomens,ren sneom: . reonavn an amno an ano comrses a varae reonanvne aunr amern eoxe a amc s c sae eru u ee emnce nceo as asm se seenso o,r ren sneoman: an.o comrses a varae neurer exemar emomens,en sneoman: . reonavn an amno a ano comrses a varae neurer exemc saeru eemnce as seor n : . reonavn an amno ac seuenceo asm seenso,ren sneoman: an.o comrses a varae reonaneurer exemar emomens,e sneoman ano comrses a varae nvne aunr amern eoxe amc saeru eemnceo asm seenso,ren : . reonavn an amno ac seuence as s sneoman ano comrses a varae reonanvne aunr amern eoxe amc saeru eemnceo ameenso,ren sneoman: an.o comrses a varae neurer exemar emosm seor n : . reonavn an amno ac seuenc ens,e sneoman ano comrses a varae reonanvne aunr amern eoxe amc saeru emeo asm seenso,ren sneoman: an.o comrses a varae neurer exemarence as seor n : . reonavn an amno ac s emomens,e sneoman ano comrses a varae reonanvne aunr amern eoxe amaeru eemnceo asm seenso,ren sneoman: an.o comrses a varae neurer ec seuence as seor n : . reonavn an amnxemar emomens,e sneoman ano comrses a varae n some emoom acens s,eueen scne aes seomoarn anno ma c:om. e comnaon o e , an an eav canrs vear aa seeu reenceon maacerom seor nae or one as seorcconrnae,n s.oamee em.omens,e sneoman ano ma comrse a seuence xemar eav can varae reonacone xemareav can varae reonacone xemareav can varae reonacone xemareav can varae reonacone xemareav can varae reonacone xemareav can varae reonacone aesno accounenseron oe comee amno ac seuenc e , an noeumanzeeav can varae ree o eac oe reerenceoeoson o amno ac re onacone an w suc, uonnserne come sues arueo : oae.s ,e ramewor we amno ac seuence o eac oe , an enera coverosono,eenera croavmeerwoorson woene,rae coverraomsewonor, w ane ramewor wenera coveroson-.ncee o s ma var s ,eosonn oeramewors ma va en oe erson sene ar we aeo r accorn.owever, a anm eermneeoson numer o aven varae reon ac seune e an w nce aso snea eoxemar: em oomaenes,.e sneoman ano comrses an amno ac seune ance aso snea eoxr remn nar emom: :en. .s,e sneoman ano comrses an amno ac seune a ona exemar emomens,e sneoman ano comrses an amno ac seunn e ace as n o snea eoxremnar emom:en.s,e sneoman ano comrses an amno ac seune ace as nc o snea eoxremnar emom:en.s,e sneoman ano comrses an amno n ae aso snea eoxremnar emom:. ac seuenc ens,e sneoman ano comrses an amno n ae aso seor n :. ac seuence ana exemar emomens,e sneoman ano comrses an amno ac seune a s nce ao snea eoxremnar emom:en.s,e sneoman ano comrses an amno ac seune a s nce aso snea eoxremnar emom:en.s,e sneoman ano comrses an amno ac seun a o snea eoxremnar emom:en.s,e sneoman ano comrses an amno nen ace aso snea eoxr n :. ac seuence as se emar emomens,e sneoman ano comrses an amno ac seun a ona eoxremnar emom:en.s,e sneoman ano comrses an amno ac seunen e ace as nce aso s sne ea eo oxr remnar emom:en.s,e sneoman ano comrses an amno ac seun a ona exemnar emom:en.s,e sneoman ano comrses an amno nen ace aso snea eoxremnar :. ac seuence as seor n emom:en.s,e sneoman ano comrses an amno ac seune a ona exemar emomens,e sneoman ano comrses an amno ac seunn e ace as n o snea eoxremnar emom:en.s,e sneoman ano comrses an amno ac seune ace as nc o snea eoxremnar emom:en.s,e sneoman ano comrses an amno n ae aso snea eoxremnar emom:. ac seuenc ens,e sneoman ano comrses an amno n ae aso seor n :. ac seuence ana exemar emomens,e sneoman ano comrses an amno ac seune a s nce ao snea eoxremnar emom:en.s,e sneoman ano comrses an amno ac seune a s nce aso snea eoxremnar emom:en.s,e sneoman ano comrses an amno ac seun a o snea eoxremnar emom:en.s,e sneoman ano comrses an amno nen ace aso snea eoxr n :. ac seuence as se emar emomens,e sneoman ano comrses an amno ac seun a ona eoxremnar emom:en.s,e sneoman ano comrses an amno ac seunen e ace as nce aso s sne ea eo oxr remnar emom:en.s,e sneoman ano comrses an amno ac seun a ona exemnar emom:en.s,e sneoman ano comrses an amno nen ace aso snea eoxremnar :. ac seuence as seor n emom:en.s,e sneoman ano comrses an amno ac seune aona exemar emomens,e sneoman ano comrses an amno ac seunn e ace as no snea eoxremnar emom:en.s,e sneoman ano comrses an amno ac seune ace as nco snea eoxremnar emom:en.s,e sneoman ano comrses an amno n ae aso snea eoxremnar emom:. ac seuenc ens,e sneoman ano comrses an amno n ae aso seorn :. ac seuence ana exemar emomens,e sneoman ano comrses an amno ac seune as nce ao snea eoxremnar emom:en.s,e sneoman ano comrses an amno ac seune as nce aso snea eoxremnar emom:en.s,e sneoman ano comrses an amno ac seun ao snea eoxremnar emom:en.s,e sneoman ano comrses an amno nen ace aso snea eoxrn :. ac seuence as seemar emomens,e sneoman ano comrses an amno ac seun aona eoxremnar emom:en.s,e sneoman ano comrses an amno ac seunen e ace as nce aso s sne ea eo oxr remnar emom:en.s,e sneoman ano comrses an amno ac seun aona exemnar emom:en.s,e sneoman ano comrses an amno nen ace aso snea eoxremnar :. ac seuence as seorn emom:ens.,e sneoman ano comrses an amno ac seune aona exemar emomens,e sneoman ano comrses an amno ac seunn e ace as no snea eoxremnar emom:en.s,e sneoman ano comrses an amno ac seune ace as nco snea eoxremnar emom:en.s,e sneoman ano comrses an amno n ae aso snea eoxremnar emom:. ac seuenc ens,e sneoman ano comrses an amno n ae aso seorn :. ac seuence ana exemar emomens,e sneoman ano comrses an amno ac seune as nce ao snea eoxremnar emom:en.s,e sneoman ano comrses an amno ac seune as nce aso snea eoxremnar emom:en.s,e sneoman ano comrses an amno ac seun ao snea eoxremnar emom:en.s,e sneoman ano comrses an amno nen ace aso snea eoxrn :. ac seuence as seemar emomens,e sneoman ano comrses an amno ac seun aona eoxremnar emom:en.s,e sneoman ano comrses an amno ac seunen e ace as nce aso s sne ea eo oxr remnar emom:en.s,e sneoman ano comrses an amno ac seun aona exemnar emom:en.s,e sneoman ano comrses an amno nen ace aso snea eoxremnar :. ac seuence as seorn emom:ens.,e sneoman ano comrses an amno ac seune aona exemar emomens,e sneoman ano comrses an amno ac seunn e ace as no snea eoxremnar emom:en.s,e sneoman ano comrses an amno ac seune ace as nco snea eoxremnar emom:en.s,e sneoman ano comrses an amno n ae aso snea eoxremnar emom:. ac seuenc ens,e sneoman ano comrses an amno n ae aso seorn :. ac seuence ana exemar emomens,e sneoman ano comrses an amno ac seune as nce ao snea eoxremnar emom:en.s,e sneoman ano comrses an amno ac seune as nce aso snea eoxremnar emom:en.s,e sneoman ano comrses an amno ac seun ao snea eoxremnar emom:en.s,e sneoman ano comrses an amno nen ace aso snea eoxrn :. ac seuence as seemar emomens,e sneoman ano comrses an amno ac seun aona eoxremnar emom:en.s,e sneoman ano comrses an amno ac seunen e ace as nce aso s sne ea eo oxr remnar emom:en.s,e sneoman ano comrses an amno ac seun aona exemnar emom:en.s,e sneoman ano comrses an amno nen ace aso snea eoxremnar :. ac seuence as seorn emom:ens.,e sneoman ano comrses an amno ac seune aona exemar emomens,e sneoman ano comrses an amno ac seunn e ace as no snea eoxremnar emom:en.s,e sneoman ano comrses an amno ac seune ace as nco snea eoxremnar emom:en.s,e sneoman ano comrses an amno n ae aso snea eoxremnar emom:. ac seuenc ens,e sneoman ano comrses an amno n ae aso seorn :. ac seuence ana exemar emomens,e sneoman ano comrses an amno ac seune as nce ao snea eoxremnar emom:en.s,e sneoman ano comrses an amno ac seune as nce aso snea eoxremnar emom:en.s,e sneoman ano comrses an amno ac seun ao snea eoxremnar emom:en.s,e sneoman ano comrses an amno nen ace aso snea eoxrn :. ac seuence as seemar emomens,e sneoman ano comrses an amno ac seun aona eoxremnar emom:en.s,e sneoman ano comrses an amno ac seunen e ace as nce aso s sne ea eo oxr remnar emom:en.s,e sneoman ano comrses an amno ac seun aona exemnar emom:en.s,e sneoman ano comrses an amno nen ace aso snea eoxremnar :. ac seuence as seorn emom:ens.,e sneoman ano comrses an amno ac seune aona exemar emomens,e sneoman ano comrses an amno ac seunn e ace as no snea eoxremnar emom:en.s,e sneoman ano comrses an amno ac seune ace as nco snea eoxremnar emom:en.s,e sneoman ano comrses an amno n ae aso snea eoxremnar emom:. ac seuenc ens,e sneoman ano comrses an amno n ae aso seorn :. ac seuence ana exemar emomens,e sneoman ano comrses an amno ac seune as nce ao snea eoxremnar emom:en.s,e sneoman ano comrses an amno ac seune as nce aso snea eoxremnar emom:en.s,e sneoman ano comrses an amno ac seun ao snea eoxremnar emom:en.s,e sneoman ano comrses an amno nen ace aso snea eoxrn :. ac seuence as seemar emomens,e sneoman ano comrses an amno ac seun aona eoxremnar emom:en.s,e sneoman ano comrses an amno ac seunen e ace as nce aso s sne ea eo oxr remnar emom:en.s,e sneoman ano comrses an amno ac seun aona exemnar emom:en.s,e sneoman ano comrses an amno nen ace aso snea eoxremnar :. ac seuence as seorn emom:ens.,e sneoman ano comrses an amno ac seune aona exemar emomens,e sneoman ano comrses an amno ac seunn e ace as no snea eoxremnar emom:en.s,e sneoman ano comrses an amno ac seune ace as nco snea eoxremnar emom:en.s,e sneoman ano comrses an amno n ae aso snea eoxremnar emom:. ac seuenc ens,e sneoman ano comrses an amno n ae aso seorn :. ac seuence ana exemar emomens,e sneoman ano comrses an amno ac seune as nce ao snea eoxremnar emom:en.s,e sneoman ano comrses an amno ac seune as nce aso snea eoxremnar emom:en.s,e sneoman ano comrses an amno ac seun ao snea eoxremnar emom:en.s,e sneoman ano comrses an amno nen ace aso snea eoxrn :. ac seuence as seemar emomens,e sneoman ano comrses an amno ac seun aona eoxremnar emom:en.s,e sneoman ano comrses an amno ac seunen e ace as nce aso s sne ea eo oxr remnar emom:en.s,e sneoman ano comrses an amno ac seun aona exemnar emom:en.s,e sneoman ano comrses an amno nen ace aso snea eoxremnar :. ac seuence as seorn emom:ens.,e sneoman ano comrses an amno ac seune ancona exemar emomens,e sneoman ano comrses an amno ac seune ae as nce ao snea eoxremnar emom:en.s,e sneoman ano comrses an amno ac seune as nce aso s sne ea eo oxremnar emom:en.s,e sneoman ano comrses an amno ac seun aona exremnar emom:en.s,e sneoman ano comrses an amno nen ace aso snea eoxremnar e :. ac seuen momens,e sneoman ano comrses an amno n ace as seorn :. ac seuence aona exemar emomens,e sneoman ano comrses an amno ac seun aso snea eoxremnar emom:en.s,e sneoman ano comrses an amno ac seunen e ace as nce aso s sne ea eo oxr remn nar emom:en.s,e sneoman ano comrses an amno ac seune aona exemar emom:en.s,e sneoman ano comrses an amno nn ace aso snea eoxremnar emo:. ac seuence a mens,e sneoman ano comrses an amno n aso sneaorn :. ac seuence as se exemar emomens,e sneoman ano comrses an amno n exemar eomronmens, sne:om. var an anoes comrsne s oreav can ,ae reons seorn :,,,,,,,,,,, ,,,,,,,,,,,,,,,,,,,,,,,,,, ,,,,,,, orum,anz,e ve,rson,ser,eo a,rea,rcu,ar s,eec,e., ereo cno amnoer exemar emomen,e sneoman ano or anennnramen n exermsesare emeaovm ceanns, oee s sneoman ano scose eren. as seor neoman ano comrses an amno ac seuence n exnemar emo:. as seor mens,e sneoman ano comrses an amno ac seuence nen o :. seuence a er exemar emomens,e sneoman ano comrses an amno ac seuencens asur seero erxemnar emo:me.ns,e sneoman ano comrses an amno ac ac seunene se ce ausror ser enxemar em:o.mens,e sneoman ano comrses an amno seuencen oer exeemorarn emomens:,.e sneoman ano comrses an amno ac n a os seer eoxremna :. seuence as seor nr emom:ens,e sneoman ano comrses an amno ac seuencen oer exemar emomen.s,e sneoman ano comrses an amno ac seuencen a os seer eoxremnar emom:en.s,e sneoman ano comrses an amno ac seuencen a a os se s ser eoxremnar emom:en.s,e sneoman ano comrses an amno ac seuencen oeer eoxremnar emom:ens.,e sneoman ano comrses an amno ac n a os seer eoxremna : . seuence as seor nr emom:ens.,e sneoman ano comrses an amno ac seuencen oer exemar emomens,e sneoman ano comrses an amno ac seuencen a os seer eoxremnar emom:ens.,e sneoman ano comrses an amno ac seuencen a os seer eoxremnar emom:ens.,e sneoman ano comrses an amno ac n a ssom seenosrancnes,en:. ac seuence seorn a n aen oeresenscosureoes no comrsee amno n somensances,ne onne on aen ooes:re-sen,-scos,ureooe. ac seuence s s no comrsee amno n someensoarncens,enn a:en. ac seue oeresenscosureoes no comrsee amno n snoce seorn :. ac seumensances,enn aen oeresenscosureoes no comrsee amno ac seune e sn noc cme ee se snsoarncens,enn a:en. oeresenscosureoes no comrsee amno n someensoarncens,enn a:en. ac seue oeresenscosureoes no comrsee amno n snoce seorn :. seue mensances,enn aen oeresenscosure ma comrsee amno ac comrncsees se an aomrnon a acn s oeneue o os:-,-, o rovea aso :, :, nce as seorn an one o s:-, :, :,:, :, :, :, :, :, :,:,: :, :, :, :, :, ,: :, :, :, :, :, :, ,: :, :, :, :, :, ,: :, :, :, :, :, :, ,:, :,:,:,:,:,:, :, :, ,:, :, :, :, : :, :, :, :, :,:,:,:,:,:, :, :, n accorance w :, or :. amno ac seuence comnaeonre osenasecosu aren ae smnerezaoomnanom ano ma comrsee n some emomens,emerzaonoman ma comran. ereo.n oer emomens,emerza se : or a varan ereo.emerza onoman ma comrse : or a varan varanereon onoman ma aso comrse : or : or a ne em coommennas,one wm eerzearonoman m:a o cormrse : or a: vara onr a vearreoan. eerreeoo..nneur emero emmoenms,enes,meerzmaeronzaoman ma comrse : or a varan varaner onoman ma comrse : or a amno accceoo ser. unence, ans s exemar emomense sneoman ano ma comrse an ae eornae. rexemonaarceoanve can varae xemarmerzaonoman rexemonaarceoanve can varae xemarmerzaonoman rexemonaarceoanve can varae xemarmerzaonoman rexemonaarceoanve can varae xemarmerzaonoman rexemonaarceoanve can varae xemarmerzaonoman rexemonaarceoanve can varae xemarmerzaonoman rexemonaarceoanve can varae xemarmerzaonoman rexemonaarceoanve can varae xemarmerzaonoman rexemonaarceoanve can varae xemarmerzaonoman o an annon o ar aennse onnenresernamsecnosuerere coomarse one or more anennnomans aens oeresenscosure comrse no .or exame,enn oman anoscose one or more anennnomans o a sne sneoman eren.or exame,enn aen ma comrsee s o a reon oe snsceosoemaenrens.cons aenoereern ex oarm aeo,roennereno. aen ma comrsee varae emomensso oe unnenrsoo aenesre cnomarsneo anowenn renrenseno emxeamar an non-mn anoe ns o sneoman anenns n s.ome emomens,enn aen oeresenscosure, comrses one or more some emonmenosm,anesnan se acenca oneroesernooscaossu cree, c soumrace anen- .n nnomansano aerenare rses one or more anen comrsex oemne oarr m eomreo anmeenns onnnnom aaneann ss oae.resenscosurencueosea comrsn amno acs oe exr secca no aeas one eoe e amnomens onn aens oearceeseunarscoomsuarnencue oosea co.mrseer on eexe omr maorre e censenne rncomomaansn oa sec.can somne eom aoeamsen onse, eeoe comrsn amno acs o more anennnomansa sec nn aen comrse one or n an emomen,enn acean ono a anenscoseeren. anennn eresenscosure comrses one or more nn a omansa seccanouman .n anoer emomen,e seccaenn oo cenoremsoenusscosure. cno amnorseers e omneo orm menore anennnomansa scosure comrses one or mo ,enn aen oeresen . re anennnomansa secca noesus anenonrenarocmuaanrs,ae secncn aen oeresenscosure comrses one or more n oer e anoe ore ouman . anennnmomoanmsen os, a naeven ann aoens os,e anresoerns acosure comrse one or more e s or varae reons an o anoes ann anenannso . ereo mae exresse as a sneoee canoen nramens moecues an varans.umerou erae sne canvsc s we,e s or vsaormas are conemae asncaeeow. exresse as a sneoee craane reereon orov mun meu snvaeenceom ananor a mnuoseesc mcaoe eversnn or a aven. oonreeorvaecr,o mnsu weoe.umee cans mae assemeoncreasee eow. rousormas are conemae asncae anoecscorscnose, anereenn mnaner uasemenos oren aenraeennnnomans oe sneoman musecc, monovaen n aensa are monosecc, c, o orr exam-e,e voa o mrr aa mu ne o reva anoe ann n o.r s o a sneoman ano caneuse w a muvaenn oo aowomomerzaonereeneran a caneuseernnaavn ne a e,m men wu. ree cuorees s oaceers v oarraneer rseoonen oerrae as m ou av sanene anom maonno asneco nn a c w aco,re enx.am ore,-e varaomea renoon as oor s owo sneoman anoes caneuse an mus weeromerzaonereeneran a muvaen euseneernc aac nveen m w,ne v a reare uan. ree r seaocenrss o orrnesr osowoen oerr maoere a s mnuevaoemna ann an muoes ma nn ae secc nnrnn amn. en aeenreso o, aeresenscosure maave aorma o an ano or anen ano or w an anenn annno-omaen m ooe acu sen,acv-e, an-ousuosnes a wn ae sneoman wroen scaos,mmune ce mouan ae e, auson nn aens asoncuemmune ce mnosu anane ae. an rearen moecues s, cmerc anen receoernss suc a csonosrr euxcasm,se,ecuac- en ceae ersnaers consruc s,seccer ce enaers s,rseccer ce nrs conann scvs or s. roens,-nom aanen os asoa encoomcocacsussusroon wroen scaos,ncun anrn reea xemar emomens onn aensennc-u,e moen-osecrocn-,ens,ecnocsn asnmmeerc oer. a msummvaeernc arnseocecs,-, s orn meu csaecnc asnoes as we as monovaen,vaen,rvaen orerao,anem-scvs, scs anervaves sucao,rao, -ao,o an anemr-scvs, sc-c, mnosc-,anemao, musec ee, or s anervaves suc as,anemsecc or usons,cen,vaen -cusons, -ne-- usons,vaen oma snns aess ca ocaano ev, o me ooc rea mcuo aeas a rcn ev ce nome nr.s ses a oman an a oman.e an ne aeener. sc e.esewoomans areurer covaense-ermnaar oe s v moecuesenoe as eer-- e oman ar oe scv mo cv moecue, or as-- e omanse-ermna ne ecue.eosor man scv moecues anesnn suaeee “nrse areaenscrvse.”n..ao.o:.,-,,. an.a...o.r,,,.aa an. ow, noaraee an..aer,nean scosen snome emomonesn,s,en, eno on ae: encesm o- ere,resen. anscousure maave aorma as unero. ,e enre conen o wcsncororase onune, suc asor exame, asormuaa,or eeren reerence ormua,ormua,ormua ormorumaua,orm anuace,orem ouraorm,uoarm,uoarmu,aor,muoram, ,ormuaa anormua,ormua,ormua,ormua,or ua scoseere mua orormua oeee cnn. annsa avenns oe samee coresenscosure maeorme e assem owo avn er nuraonw same oreren amno ac seuence or conuraon seeno cronnuorarmounas, woremreuae, soarmmeua or,oreren conuraonsncuee ,ormua,ormua,ormua or muaa anormua,ormua n some emomens,enno armenusa oescoseeren. some emomens,en resenscosures monosecc.n enn aens on aeenrs oeresenscosures musecc. ramensereo mae monosecesce,n musscoescurec, mnocnuovanen an or mouesva oren an.ennn anos cnonnse areen muav caomen.rse msuwov oare mno sren aneoenmann annooma canns o a sneoman a anennnomansno exac e same eoe or mu e monosecc nnomansnoeren eoes on sameare oroersecc e anen nn aena comrses on one anennnom en eoes orares. roucon onn aens suc as ano ans consere monovaen. connroceures an r es or anennnramens, manvove se ecomnan exresson.e anennnoman seuencee.., oueen vcaer oaee veaavra cean o c a sann aeno vmaraan aeneaov c maan oe a onannaec ano ore seuence connroceures, suc as-,’- , an c a vare o moecuarneres mae coneno an exre rar screenn.e seuence o anenn aensoae anorssuorn veec.onrse, caese ex or aenssnonac ve acnorosr,anseece cnaon c aes eeav can cane coneno a sne exresson vecor orno n vecors.o-ransecon oe seara wo searae exresson assemeroer.ne case o a snee exormesasno ann vecoors, as s nneceess eaxrreossrone venac anoo eeav cans s corexressn eoe oonoseccucnenn. aens encomassnn aensa are seccor a sne n aven anen. comrse o enxeem anaren emnonmenra om ae mnon oos aec sncenonma anen anncoue.s anonenr e axeena emomen o a monoseccnn aenncues ann aena com mar anennnramens o a sneoman ano,ue a rse morean one enca s anramewor reons.e anoe nennnramensavencues ann aena comrse mo r exemar emomen o ann aen anoes,ue vara rean one anennnramens o sneoman exe e reonsaveenca s anerenramewor reons.urer anmenarn emnorammenen os o a m sonnoeseocmacn annno aeesnancueers anne anmn aoe anc sa comrse one or more oer se.., conservave susuo euence o er a onoe same anen or eoe. nn one or more s wou aecn eoeousee scamce annnen a orense ernecnom anassensn onro a meonsa are seccor morean one museccoee can ornn rean one anen.or exame, a a sneoman aen mausave morean one varae reon o en anno ae,n aeaswo o wcnoeren anens or eoes.erasec s oeresenscosure mausesecc,rsecc, seccorc, aenveans aencecn,.enxa ssomece emc eoc.mne snome emomens, eac varae reon mae vennn aen mae s s,wo or more anennnramens o a re eccore same oreren anens.n some emomens, eere onr m aonre aenns.enn snomne emraomemnesn os, aouvren or mnn aen mae seccore same or nn aen mae seccore sa ore anennnramens o aven more an me oreren anens.n some emomens,ve or anens.enn somnen emroammeennss o, s ax orve mnoren anne anenn manre seccore same oreren mae seccore same oreren a amens o avennn aen anennnramensr nens.e secc maeen one numer o er exemar none-semnnn a emveonmnenns o aen. avnwo anennnramens o museccnn aensncueose emomens o mu eren secces.e oer exemar non-mn ram seccnn aensncueoseavn moreanwo anennn aneenns osraroennsowoeren anens,roens orowoeren eoes one same nn s soommee e em. moommeenns,enn aen oeresenscosures monovaen. xemar no s,enn aen oeresenscosures muvaen. comose o muvan-enmon eemoem cenasns o. muerva noenn-mnnn a exeenmsnacru eemnonme aens muvaennn aensncuenn aens comose o morea ns o oee can n one monovaen muvanen acceorena.ncne w onee numreseern o vsacroasuere r,e aonssecac connanns a.exnem maare nonv-amenn or emooemene cs oanssaecorcm anmne aensncueose comrsnwoencasecc nxe sommea erm ano nmone-nmn er.momens oseccnn aens areroveeren. anso an coms,rseessoremcucansene aen comrses an aneen onnnoman , anuse onune, , unero. e e ecemer,serenncororae reer nre conen o wc a-on- oermern eamomens,encee.nn aen comrses aoee cana comrsesn c amerzaonomasano,n, a a ann aenr anennnoman o a sneoman ano, aner, aeas one oe anennnoma en a on a an oren ens ann anomean o a sneoman ano, . nnnomananso o e aren some emomens,e anennnoman o a ane anennnoman o e aren seoemre saen m eem. .omens,e anennnoman o a ane anennnoman nn s soommee e emmoommeennss,,eenneerr o o a anneenner o aree same. n an exemar emomen,e er o areeren. nno anennnoman o a comrses an anen n amnoane or e axe smnaero emmano anmeno,ea an seecncnannosouman . nnoman o a sneoman anoa seccanmsaon o a c soumcr asseso arn e axnaen uman . me nnno amna enxe omar emomen,e anennnoman o e comrses an anen n an exem a sanr eemoomamne ann,oe anae snecncanonmasno oum ea cno . nnoman o a sneoman an mrses an anen uman . oa seccanso , suc asor exame woon seomee e cmaonsm areen nso,n-ecseccnn aen comrseswooee cans.e oman conaneeren soo avsaoen oa anss aemseecc a amnno ac resues oe anor sn an exemar emomen, eravaennn aen. sco enn aen or anennnomans oeresen .ure mae caae onnerow oumor ces exressnuman an omansn exemar emomens,enn aen comrses one or more anennn n aano aree cra exaeme oarn emnoo . nnomansa are caae omnenns,oenn an a oenne o cro mmrses one or more anen a are c ore anennnomans cona m aanrs ee exse o :mnarn emoomen.,e anennnomanas caae onno a.avn ae amno aacvn seueen acme sno ac seuence seorn , a e amno ac seuence seor eorn : an a avn .avn ae amno aacvnn seueen acme sneo aoc: r sneu,e onrce seo:r ann a a, a e amno ac seuen vn n an exe ce seorn :. comrsesm an aamrn eom aco smeeune,ncee as an seeonnnomanas caae onno n an exemar emomen,enn arenns ca :. an comrses an amno ac seue ae onno an o aeas one anennnomnacen a os s aeeoars onne sneom: ane amno ac seuence nn oer exemar emomens,enn aen maan c aonmrose asceaosse oneer aenn.en nnnooman ca aane oa conmnrseso an amn aon a aeas one anennnoman caae oeas one sneoman ano seorn an ocne s oeuence o ans a:n-en,nnooms:an- o a. :s:,-, :,:, :,:, :, :, :, :, : :, :, :, : , :, :, :, :, :, ,:,:,:,:,:,:,:, :,:,:,:,:,:,:,:,: :, :, :, :, , :, :, :, :, :, :, :, : :, :, :, :, : , :, :, :, :, ,:,:,:,:,:,:,:,:, :,n oer exem:ar, o er :.nnoman momens,enn aen ma comrse aeas one anennno ca anaea onno an aeas one anennnoman caae ooman anoscose coemrenrses an amno ac seuence o aumanze verson oe snennno omaenr e cxaemaear o emno. nmens,enn aen ma comrse aeas one anennn o- an aeas one anennnoman caae onnno o oer ex.emar emomens,enn aen ma comrse aeas one anennnoman c aanae onno aeas one anennnoman caae o n an exemar a eemas one anennnoman caae onno-. comrses: omen,e anennnomanas caae onno- a.avn ae amno aacvn seuee amno ac seuence seorn , a e amno ac seuence seornnce seor:n, or : an a avn .avn a avne amno ac seuence seorn :, a e amn e amno ac seuence seorn : an a avn n an exeom acar se emueoncem seorn :. comrse en,e anennnomanas caae onno- n asn a enx amno ac seuence as seorn :. a emar emomen,enn aens caae onno- an on a coemasr osnees a ann amenno ancn seuence as seorn : ane amno ac seuence n somensances,euommaannz oe a veresaosn oneer sneoman anoscoseeren. oerramewor reonsorose o a corresonneoumasan re oacemen o amno ac resues n somensances,eumanze versonas reacemen oerruramanzeramewor reons. ormewno :.n oernsanc mewor reonorose se ra es,eumanze versonas reacemen oer orosenr s seo remoeo r enmor no anmos oee nn s e,e oeorumnanzes v:erso: ,na,s. reacemen oerramewor reon ,,,,,,, ,,,,,,,, n some em ,,,,,, or. orose seorno anm oenne, oeumanzes v:ersonas resacemen oerramewor reon ,,,r e,xem,ar, em, :,,,,,,, n anoe om,en,,e,nn, ae,ns, caa,e o orn.no an :. an comrses an amno ac seuence as seorn : orn aransanranns a oene o seueencreessenscoscseosureerener aereo areso e encomasse eresenscosure. oman ano varans, varans o ano-e moecnuceo,m varasasn ano varanse.., sne ommune ce mouan aen.n aon,nn aens os oerroeseenn scascoos,u vraer manas c aonm anrseen an annnenranmenn orra anm aenn oer an anennnoman o an ano varan suc as eresenscosure moreanrcnuanr eonmcaomn oas ase ssn vaeraonmsa on aneo sn vearaon. anoscoseeren as we asnn aensa comrse o man oman o a sneoman ano varan ne or more anennn avee sameorma asenn aen.scoasreanser oen.es snucn, v aareannss oscoesenenren ma encomasse eresenscosure mae musec aens encomasse eresensco c anor muvaen.arans more amno ac resues a one ors muorerencosueon,o asee weoc ma comrse annseron o one or one or moreoson or a susuon o one or more amnno o ac one re osr mueosre a am ono ac resues a conservave or non-conserv ne or moreoson aen suce a vsaraeomne mraza ococa nurven sues anuoenns.nnoman orn oer eemens oenn or exame, naura oocmcuarrn,ner or sacer. canroeres.onservave susuno rness muaes aere mavee exncoanrouns aase on common se oerousseeowrouoor anoer n amno acrom one conservave susuon amno ac oe samerou.on- a,eurocus w en neeu,sora eo ex ucoc nca:n nonreu ac mneem, meer oo onnnee oees,eraonunseor aan,oaer.ne saranrou neuraeroec:senes,erneer,reonner, reosn,uamnen, rouu acascc::ssarnec acs,ss,neuamc ac u rou resuesanuence can orensa,orn:nnecr ro an ne ,rone er exemrouar e amromoamce:nrs oo conasnervarv,e surosner,enaannee eean o "reerre susuons". suc susuonss ruesuonsn ar aen s unowesnrenaroeer u,neenr meosrcer seuseanowan c reanerees,enomnae "exemar susuons"nae, or asurer ne o snenc aero w am rencoo acnze casases c,e mraanenrouce aneroucs screene. are neura, are neave care orave a reuce ca armenno c aocmsa arreessosve care, mno acs cane caeorzease on ne care asncae anso anmono o acer’ asmsnooe aeccs. on.esoeecrconse a wce averae ne car rc s zero.en , an amno ac e oe amno ac moecue as a neosve care.n some emaos am neen nse,aev mee casaurre, an wene , an amno ac aou ane...,.,., e vaueor an anoseween an an .,.,.,.,.,.,.,.,.,.,.,.,., an eween a vaouues annewee.e.n..n, s.om,e. e,momens,e measure vaueor an anos soeecrcons o amno acs are sown.,n.a,.e,.eo,w an. aenne vauesneween.xemar eecrca care se cansnc ra amno acs wosve mno acs ue,or exame,rnne,sne, ansne. anua wmc necave. eemcrncoa ac csa wre soaer croanesrenscue,or exame,sarcc reonne,sarane, ncue,or exame,erne, .on-oar a uamne, ansene,rosne anroan ,eonnemn,o acensancanunee,or, examcnee,a annnero,nane,soeucne,eucne susunon so.meee, e em..omens,esoe.enc srocmeo emn o an aneo.s moe va amno ac aoee comrsn an omens, monesoeecrcon o ae.xema ano resusn a canene ano’sa-e. rna resuexerm amarno su acs suuosuons a aeuenonservavea susuon soeecrcon rna resuexemar sausuononservavea susuon soeecrcon eren usne,as e seuences - a newoo seoure cnocmeraornramaana.ausova,omas.aen , "as :- usneau sens,.e.,roaesn anro nuracme,oe seuences m",arxoecrooe. exensonaena axroo, exec., wo na an ercenen wereoree r sze an acvaeers. comarson we ornaee an wcn mcaav oecc ou ameno sam ace osr s wmc areencan ercen smar wencave o amno a aroson. reace w con cs wc areenca anose wc are same or s servave amno ac susuonn comarson we ornaee ae amranars ooson. ,,,e,rese,ns,cosur,e ma,ere,ore c,omr,se a s,euen,ce,as a,eas,,, o an, or,na se,uence o.r enca wa o an orna or reerence seuence or aoron rneon mna an eexemeroarrme emo ammenno, a mcua suonssun oonne. orx memorear ems, voarameen rse oon su ors counsoanns xceumea cron ssuervsauveon asm arneo arocve susnuons or non-conservave amno ac susuons. ae.e oer exemar ae.er exemar susuons areroven n some emomens,o suesueo cnsa anrsearovenae. , ,,, enca oressvna an amno ac seuence wcs aeas seuence, maave amno ac susu n encao aven amno ac ouse oe come ons, aons oreeonsa areeneraocae n some emomemneanrs, a veaerramnn mna reaons. scoseeren.n oer ve aeas seuenceen w a seuence seuen emomens, a varan maave aeas seuenceen w a w ac seeusecnocseesecreosne.neree enm.noumreners, e am vaoranme mnas,ave aeas seuenceen seuenceen w a seuencescose a varan maave aeaseas seuence eren.n oer emomens, a varan maave a n some emoenmens w, var aa seuencescoseeren. or ex on ma occurn one or more s.e muaons ma occur an exeammaer,n emom amenn,o a amcno re ascu reessaues ar oe nonvo anveornen meraaceon m wu .n exemar emomens, amno ac resues o mae mu ae.n oermrove an w a ae. muaonsa n oer rearcuar conemae. occuror exam eme,onmeenrasm, veawroaro anm mnao a occcu rresnueramewor reons.e muaons ma w .n an exemar emome esa are nonvoveneneracon e muae.n oer exemar n, amno ac resues o an anor ma muaonsamr emomens, amno ac resues o mae muae. n oer emoove amenns, we var arearcuar conemae. emomen,e consan reon maaeo mnsu maae o scocu arsno meo cuonasean reon ac.nv an. enxe amnoarer e axneomerar emomen,e consan reon mae muae so aso mouae acv.n acv. enxeme oarer e emxomen,e consan reon mae muae so asomrove nernazaon.neemar emomen,e consan reon mae muae so asomrove mrove s oer exemar emomen,e consan reon mae muae so aso xeamar. reonamrov aens o non-mn emomens o muaonsne consan reone..,c exemar e ne or more eecoruncons are encomasse eresenscosure, ase.moovmens o: w,ce e,n arree cornovene o wneae s ouaonsnoes ae csncororaeeren reerence. cocaons ecoruncon vs. eerence eren.xnemnar ae anns n coonm-rmsnn o enme oor mmoeren asn o sennenonmano amnanos o va ornaen osr a mreorove oman ano varans are aso encomasse eresenscosu re sne varaxemar varans oeresenscosure mancueore.ees comrsne ,e reon seuence oreav can seuence oae,ae,ae oae susuaoe,ae orae w one or more varaons seecerom amno ac amno acn s,ueseuonon asn,roorm a oneoon.ve aem vanroa acon meaeonncsu aneoorrr eoxmam oneeoromve oneovenseron.n an exemar emomen,eeeon or aons are c amno ac exemar emomen,eeeon or aons are non onsecuve.n anoer emomen,eeeon or aons ar -consecuves.ne anoer exemar eeeon or aons are a e ae-ermnus.n aurer exemar emomen, or aons are o e-ermnus.ne aurer exemar emomen,eeeon eeon or aounsse o an seuence.ne aurer exemar emomen,e aurer exemar e amreo ouse o an seuence anor seuence.ne ne aurer exe men,eeeon or aons are ouse o anaa seuence. seuence anoramar emomen,eeeon or aons are ouse o aaa “wo”, “sr ueese”, “oeruea r”n ane “e sre vmu e” “en arc soe wm. e on aes aonv rae”ncue annvua vaues suc as “one”,owo”, “rom oneoree” ne comrseereeween suc as “rom onewooour”, “romwoov,e “”,ro “mro omneroeeouor”o,u “r”r,o “mr oonmeoreeveo”,v “e”ro amnw “ororee”, “rom arans oeresenscosure ma comrse aeas one a omourove”. comarson w a seuencescoseeren.ernave mno ac susuonn comrse aeas one amno acee , varans oeresenscosure ma ernave, varans oe onn comarson w a seuencescoseeren. comarson resenscosure ma comrse aeas one amno ac aonn amno anc so w smues e am se uoue onmnc aee nns a,scoes ea ve sar oae nnre esn o.eresenscosure ma comrse aeas one scoseeren.n some em amno aceeonn comarson w a seuenceeas one amno ac susuono anm aenesa,s oen vea armannos a oc aereosnenn cosmcoasrurseon m wa c aom seruseenc ae onsec aomsenoe aren.n some emomens,e varans oeresenscosure ma comrse aeas scoseercen. an somoen e amno ameeanss, onee amno aceeonn comarson w a seuence one amno ac susuon, aeas one am vnaroa ancs o aeornes aenscosure ma comrse aeasn comarson w a seu n aeas one amno aceeon n some emomeenncse,sec aomseno aeren. amno ac se c susuon,eeon or aons ouse oe su uence o oraa.n some emomens,e amno ac n ssomue eomn,oemeeonns o,r ae amonno asc ou ssuse ouoe amno ac seuence o oraa. seuence o oraa.n some emn,oeemeonns o,r ae amonnos a ocus sues oueo anm,neo ac or aons ouse oe amno ac seuence o ora eon n an asec oeresenscosure, sneoman an a. e amno ac seuence s o varansncueoseavn n accorance weoerresnenscosure:,-. ramenereo comr e sneoman ano or anennn :sese am connose ancsu seuence seorn :. 1a 1b 1c 1s 1g 1 d 1e1f1 h 1i 1 1k.1l 1m 1n1ooccurrnn a anpm exne1omqacar re emomen, an o1ao11rsreacneenen ane.., naura resuenou anno ae ar e cxoerrms esarue e.momen, an o1ao1rs eacneenen an amno ac :, or conosenrvanvosonn an one o : or s:- susuonsereo. e amno ac susuons or non-conservave amno ac amno acne ren anoer exemar emomen, an o1ao1rs eacneenen an :, sue:oun a a corresonnosonn an one o :, amno ac susuons, or non-conse:rva orve amno ac: susuonse:reo. or conservave resue mn aurer exemar emomen, an1ao1rs eacneenen an amno ac os:osreuenoun a a corresonnosonn an one o : or resue mno a- sno. reeru eexnemoaurn em a aomen, an1ao1rs eacneenen an amno ac :, : corresonnosonn an one o :, ne anoer ex,emar em:omoen, a :. ac resueoun a a corresonnosonnn a o1ao1rs eacneenen an amno ,,, or :, or conservanv oen aem ono ac suss:uo,ns o,r no,n-,,, conserva resue mno ave su arm reen uro e e a nxcem su ouanrs eu amo aons cormreee snre o,o n a.nn1oasoo1rs eacneenen an amno ac ,,,, s or su, nn an one o s:,,, ne ar ore,r exe omr sa.r, em oromens1aors ors1,bs,, or1cs or1ds o1er s o1rfs or1g 1h 1is or1s or or1kan1l 1m 1ns or1os or1ps or1qs no anro1rers exe omrar em :. or1es or1fs, orom1egns1as1hs or,1bs or, ors1ocrs ors1odrs s or s or s or s or1i iss or1s or1ks1lor1m 1n 1o 1p 1qanor1rn a :. ramencecroeorance weresenscosure,e sneoman ano or anennn 1acomrsese amno ac seuence seor 1g 1b 1i1c11dn :. 1k 1l 1m 1n1o1e1f 1pn1qsome emomens, an1r. o1ao1rs asescreerene.., s., anon oeaver emomens an o1ao1rs a corresonn amno ac resue o an seuencen see o c orera n enm va anora onme ee on res aonn. o1a:o1rs a corresonn amno ac resue o a uman anneo oeera evm coamn,e snusc an as, oor e1xaao- m1er,s a a. re corresonn amno ac resue o a eav c sue o aermneuman ano :na anc. ccoorrreasncoen woee amrensoen acsc seosuuerne, , an n ven varae reon seuen ce oe , an o a ae, cescoseeren annarcuarnae oa ramen aca e, necroeorea cnoc o mer wae rsesee ar.emsennoscosure,e sneoman ano or anennn : conse ancsu seuence seorn :. 2a2g2b 2c2h2d22es i2 2k2l2 2fn 2ooccurrn amneomar emomen, an o2 m 2n an exp2ao2ps eacneenen ane.., naura resuenou anno ae ar a ec cxem resarue e.momen, an o2ao2ps eacneenen an amno ac : oorresonnosonn an one o : or :- susu r conservave amno ac susuons or non-conservave amno ac resueno ou an nnsoe aer areo e cx. oerrmesaorn enmoosmeonn, an o2ao2ps eacneenen an amno ac :, : or :n an one o: or con:ser, :, susuons or non-conservave amno ac susuonsereo.vave amno ac ac resnuee m aonsoreer euxeenmaorun em ao a cmorerens, aonnn2aoos2opnsn ea acnn onee oenen an am:no or resue mno a: sur- reeure e. nxemouanr e am ao cormreesn, an2ao2ps eacneenen an amno ac :, onnosonn an one o :, ne aur:er e, :o :. ac resueoun a a cxoerrmesaorn enmoosmeonn,n an an o2ao2ps eacneenen an amno ,,,,,,, or one o: or conses:rva,,,,, susuons or non-conservave a ve amno ac n an aona exemarm emno ac susuonsereo. ac re omen, an2ao2ps eacneenen an amno ,,su,e m,os,reue,n,oun, a a corresonnosonn an one o s:, n anoer exem ,,, or. resueoun a a corresaorn enmoosmeonn,n an an o one2ao2ps eacneenen an amno ac ,,,,, or : o or conservasv:e am,,,,,, or non-conservave amno a no ac susuons n aurer exemarc em suosmuenon,sereo. resue mo an2ao2ps eacneenen an amno ac ,,s,reu,en,ou,n a, a cor,reso onrn.osonn an one o s:,,, ac resnueeo aunur ae ar e cxoerrmesaorn enmoosmeonn,n an an o one2aoo2ps eacsn:e,en,en an amno ,,,,,, or : or conservave amno ac,,,, susuno annso ore nro enx-ceomnsearrva emve aommnoen ac, an susuoonssereo. resue mosreu2a 2peacneenen an amno ac ,,, enoun a a corresonnosonn an one o s:,, o,er ex,em,ar e, , n an mo,me,n, or. resueoun a a corresonnosonn an an o one2aoo2ps eacs:ne,en,en, a,n am onro ac susuons:ereo or conservave amno ac susuons or non-conservave amno ac ac resnu aen m aosoren.aue enxemouarn e am ao cormreesno,n ann2aosoo2npns a enac onneeenen an amno ,, o s:, o n, ano oerr exem.ar emomen,2as or2bs, or2cs or2dssr or2es osr or2fs, osr or2gs,s or or2hs or2is or2s or2k:.2l 2m 2n 2os or anor2ps or or ne anoer exemar emomen,s or s or o2es or2fs, or2gs or2a2hs or2b2is or2c2ss o orr2d2kss :r.2ls or2ms or2ns or2os or anor2ps or ramenn acecroeora cnocme wrsesee aresenscosure,e sneoman ano or anennn 2a 2b 2mno ac seuence seorn :. 2g q2h2c2d2i2e 2r2 2k2l2m 2f2anor moe emomen2 2nn soss, an o2p2ao2ps asescreeren an2qs,2rs anon2sos eaver. e cmano vamreanse a rne o2ao2ss a corresonn amno ac resue o an seuencene oer emomens aonn. o2ao2ss a corresonn amno ac resue o a n see ooren an one o :-. uman anor emomens an o2ao2ss a corresonn amno ac resue o a eav can.eav can, suc as,or exame, a resue o aermneuman ano2oersn or some em r s o2frso, omrens,2s2ogrsas, o or sr2b2hss, or or2i2scs or or22sds or,,2kosr, ano2l 2m 2nor2os or2ps or2qs2rs 2,esn2sor or sosme em 2ls2fso or, omrens:,2a. 2ms2gss or, o,r 2no2bs, or2cs or2ds,,, or sr or2hs2oors or2is2ors or2s ors or2ks 2rs onr acc aonraor2ss or :.p 2q: corrnce weresenscosure, , an n ven varae reesoonn seouenec aemsncoo asce seereuennce oe , an o a ae, ramen aca annarcuarnae oae, necreoorea cnoc o mer waee.resenscosure,e sneoman ano or anennn :rsese amno ac seuence seorn :. 3aonse3bnsu3csro3mdo eav can 3t 3h3i333uk33vl3m 3n 3o3e 3f3g 3p 3q 3roccurrn am e3wn an o3x3ao3 3sn an exemar emom3ysyeacneenen ane.., naura resuenou annon aeo ar a ec cxoerm resarue e.momen, an o3ao3ys eacneenen an amno ac :, :res oronnoso:nn an one o :, :, susuons or non-conservave amno ac susuo: or conservave amno ac esnuee anoer exemar emomen, nsereo. ac r an o3ao3ys eacneenen an amno : mosreuenounnerou conssn o r, :, :, n auer exemar: emoome :. s or3es or3fs, orn,3g3sas, o orr33hbss, or or3is3c,s o,r or3s3d , or or3sks or or asens o3rls or3ms, or3ns or3os or3ps 3ws o3rq 3xs o3rranor33sss o orr3ts or:3u.s or3vs or sn ore aurser o erxemar emyomen,3as or3bs, or3cs, or s3d, or3es or asen3fs,s o orr3gss,, or3hs or3is, or3or3qs o3kr3rs or3l3s or3ms or or3nss or3os osr or3ps s3xs anor3yss:.3t 3u 3v 3wexemeenerna,eoson o amno ac resuess as seoror : an as xemarn:ae eracn am. rneos auces a rreesnuecsa neumne eracnr row osono unerne. ramenereo com:rsesonsee anmsusnoo arc seu-en,ce se aonr senece vara:. 4a 4b 4c4d4e4f 4g 4h 4in4seav4kcanls 4m5b4n4o5c 5d45pe54fq4r4s5g4t5h4u 45vi54w5k4x5l 4y5m 4z 5n5aoccurrnn a anm e.xemar emomen, an o4ao5ns eacneenen ane.., naura resuenou annon aeo ar a ec cxoerrm res esaorue n e. nmoosmeonn,n an o4ao5ns eacneenen an amno ac : or conservave amno an one o s:-, os:- susu ac susuons or non-conservave amno ac ac resnon uees aneoreoe.r exemar emomen, an o4ao5ns eacneenen an amno :ou,n a a corres:onnosonn an one o :, :, susuons or non-conservave o armno ac su:suonsereo:. or conservave amno ac resue mno anoer exemar emomen, an o4ao5ns eacneenen an amno ac oss:re-uen.oun a a corresonnosonn an one o s:-, resue mno asnoreeru eexemar emomen, an o4ao5ns eacneenen an amno ac :, noun a a corresonnosonn an one aurer e: o :, n xem,ar em:o :. or,s, or,s,o orme,n,4sas or or,,4sbs or,, ors,4cs or,4ds ,4ks4eor,4ls o4fr,4s or4g,s,4ohr,s4oir,, ors,,4ors, or 4 oqs or,4rs, or,4sms,,,4 onr,4ts asen4o or,4us4p or,4vs,sr or,,4wss or,, or4x,s ors, or4ys or,4zs or5as or5bs or,5cor, s5dor,s o5re,s, or5f,s ors, or5g,s an oror,5hs or,5is :5.5k 5l 5m 5ns, oro e anoes os.ae anae aave , an enca avnne a anm asnoec ac o seeuresenscosure, sneoman ano varansncueose e..,ae an ence seorn :, :, : :,., onsensusor an varans neenne ann ex aenmea.r., e nmauorame oncc,urrnrom aosono n :s eac n oer exemar emom mno ac resue. an am ens, aosons,,, or aosons osonno acs r,es oure a aoossoonnss a,n, am orno aosons,, or a or aosons, or aosons a anc am resnou aec r aesouseon aoss,on, so asno anmnos ac, r,es,ue, o aros aonosson, osr an am aosons, or a an amno ac resue aosons an amno ac rensou aec re asouseon aosso,ns aosons,, or aosons an amno ac , ors an amno ac resue ano resue aoson n some emomens,r a aososonons osr an am anoos acon ressue or aos:o. s or aosons or aosons, or aosonsn aosons or aosons or aosons or a ors or aosons or aosons or aoso oson osons or aosons, or aosonsns or as or aosons or aosons or a or aoson anor ao oson s or n somse eon s or :. s or amoosmonens,s a oroson aosso onrs a,os orons ao osron asos oon aosons aosons or aosons or aosor or aosons or aosons or aosons anss aosons, or aosons or aoson oson osons or aosons aoson s or ans or as or or aoson osonn somse e omro:m aen. osso anosons or aosons, or a or aosons or s or aosons or aosons osons or anor aosons or aosons or a n some emomens a aososonons or :. s or aosons or s or aosons or aoson aosons or aos aosons or aosons or or aosons oons or aosons or aosons aoson s r aosons or aosons or anor :ns o eacer enxeem or enaren em aon am: mennos,. a acn r oense oueournom ao as corornesoonnnosonn an one o :,:, :,:, :,:, :, :, :, :, :, :, :, :, :, : or :, :, susuons or non-conservav : or conservave amno ac ne oer exemar eme amonmoe ancs, s auns ouonsereo. :s eacneenen an amno ac resunee m oosrreomuosono n osonn a enoun a a corresonn :n o,ne o :,:, :,:, :, :, :, :, :, :, :, :, :, :, ::, :, n an asec oeresensco or :. avne amno ac seu sure, sneoman ano varansncueose . ence seorn : or :e..,ae neenne ann ex aenmea.r., e nmauorame oncc,urrnrom amosnoo anc r, orn : s eac n some emomens aoso esue. oson ns or aosons or anor a nes e a o o mnerro e amco sumsenus,o a: nn. conservav or o a no an-coonsseorvnave or amnno ac susu:ons a ac resueoun ae co oe amno e ano rresonnosonn : or :. same anes o ana vaeraon, waen,aeures,ae anae aave avnne a anm asnoec ac o seeuernesenscosure, sneoman ano- va.ransncueose :e..,ae-.ce seorn :, : or an amnn an exemar emom:en, aoson,,,,,,,,, or s no aec o reesr eume aonmen as,o asno on aso or :. s a conservave amno ac susuonson,,,,,,,,, or e amno ac re or a non-conservave amno ac susuon o :,sueo:un, ae corres:on,nosonn: an, one o :, :, :, :, : :, :, :, :, :, :, :, :, :, :, :, :, or : an , :, an ano ssomoen emso anme anmsno a a acoso resosnon uesss a,o, or s oorns a,os: oron. as,os,on, ors os am sonno ac ,s an res amuenso ac a reossuoens aso osron aso asno anmnos ac, re,s,ues or ao aso s., or aosons,, or ano n resue r aoson s an amno ac osonn oser e omrom aenos aosons or aosons or a or aosons orson aosso onrs a orosons or aosons osons or aos aosons or a n a ons or anor aoson s or. avne anm asnoec ac o seeuernesenscosure, sneoman ano varansncueose :e..,ae .ce seorn :, : or neenne ann ex aenmea.r., e nmauomen,romosono n :s eac ano ssomoen emso anme anmsr,a no a a occ cousrronn amsno, ac, r oersue. aosons,,, or an resues aosons, or aosons res aumesno a aco ressues aosons,,, or aosons an amno ac osons,,on ors an anor am ano aocs roesues aosons,, or a : n s an amno ac resues osonn. somse e omrom aenoss,o anosson ors a oroso anossons or a or aosons or aoson or aosons osons or anor s or aosons or a n oer exemar em aooson s or :. :s eacneenen an ammennos, a acn r oense oueoromosono n one o :, :, :un, a a correson:n,osonn a:n, :,:, :, :, :, :, : or conservave a:mn,o ac sus:uon,s or non-cons:, :, or ereo. ervave amno ac susuons :ns eeac onere exeenmenar e amn amonmoe ancs, a rens ounee m oosrreomuenosoono n osonn an one un a a corresonn :, o :, :, :, :, :, :,:, :, :, :, :, or : :, :, :, avnne a anm asnoec ac o seere.senscosure, sneoman ano varansncueose :e..,ae.uence seorn :, : or neenne ann ex aemar emomen,romosono n :s eac n somen emeo..,m naura occurrn amno ac resue. aosons an amennos ac aos aons,, or aosons,, or amno ac :. osons, or anor aoson s an osonn somse e omrom aenosso anosson ors anso or aosons or a : r aoson s or :n. s o eacer enxeemenaren em aon ammennos, a acn r oense oueournom ao as corono n one o :, resonnosonn an : or :: or co,nse :, :, :, conservave amn rvave amno ac susuons or non- :ns eeac onero e e axc eenm su enars eu amo n amons nme oer aneo cs,. a rens ounee m oosromosono n osonn an one o :, :,reuen:oun, a a correso:nn, avnne a an: m asnoe,c ac o seeuernes: ceen o sesr ocrosunre, sn:eo.m:an a,no varansncueose :e..,ae . : or neenne ann ex aenmea.r., e nmauorame oncc,urr ano asmonno ac an resune. :s eac or n some em:omens, aosons,, or anor aosons,, :n some emo.mens aosons or anor aosons ors a consner o. vaevre ex aemmnoa arc em suosmuenons, o arn a n oonne-c oonse arvaosveo amnno a anc su o : amno ac resueoun ae corresonnosonn : osuon oe n an asec oeresenscosure, sneoman ano varar :. avne am.,nao ac nsncueose :e. e seu.ence seorn :, : or neenne an exemar emomen, aoson an n :s eac n snome an eme.., naura occurrn amno ac resue. amno ac omens, aosons,, or anor aosons an n so :. :me emomens aosons or anor aosons ors a consner o. vaevre ex aemmar emomens, an one o aoson an o : amno ac resueonuon ac a sue csuon or a non-conservave amno ac susuon oe n a orresonnosonn : or :. avne anm asnoec ac o seeuernesenscosure, sneoman ano varansncueose :e..,ae.ce seorn :, : or neenne ann ex aenmea.r., e nmauorame oncc,ur aoson an n :s eac o acn some emomen rn amno ac resue. amn s aosons,, or anor aosons an n so rmese eumeomens: aos. :. ons or anor aosons ors a consner ovaevre ex aemmnoa arc em suosmuenons, o an one o aoson an o : amno ac resueoun ae correr a non-conservave amno ac susuon oe n an asec oeresensscoosnuren, snoseoonmnan ano v:aran or :. avne amno ac seuence sncueose :e. seorn :, : or n an., exeamea. neenen ane.r., e nmauorame oncc,urrnrom amosnoo anon :s eac n some emomens, aoson c resue. aosons an am s,, or aosons,,, or : no ac resues anor aosons,, or osonn. somse e omro anmeonrs, a aososononss or or aos:ons or a n oer exemar emomens, an one or . :s a conservave amno ac susuon or a nono-mconosservoanve aon oe amno ac resueo mno ac susuon :. un ae corresonnosonn : or comrsen ane e axmemno aacr emomen,enn aen or anennnomansereo ma :. seuence oe seorn :, : or ereo mna ana exveemea armn emo acom seenue,ncee a ssneeneomna ann an oneo o or anens:nnoram orenn :,: or:, w orerene amno ac seuence oe s as seorn n an exemar em :. comrsee amno ac seuoenmceen o,eenn aen or anennnomansereo ma n anoer exemar emomen,e senorn anen or anen:n, onromans:er. ma comrsee amno ac seuence oe eo ac seuence oe se seorn : ane amno n anoer exemar eomronmen,e:. ma co nn aen or anennnomansereo ac semuersee amno ac seuence oe seorn : ane amno nnce oe seorn :. ma com arnsoeere e axmemar emomen,enn aen or anennnomansereo ac seu no ac seuence oe seorn : ane amno nen ance e oxemea seorn :. ereo maavee armn emo acom seenu,e sneoman ano or anennnramen : or, werene aenmceno as ace sneeuenn acne o onee o s as ses: o orn :, : or : ane amno ac seuence oorn orn : or :.n accorance we e s as se ac seuence oe ane amno ac seuence oere asreen onscosure,e amno can.ernave,n accorance weresenscosure,e amno ac a sameoee ane amno ac seuence o seuence oe n accor e are on searaeoee cans. orn ance: w,eresen:,scosuree a:m,no ac seue:nce, oe :s, as se ::,, ::, :, :, :, :, ,:,:, :, :, :, :, :, :,:,: :, :, :, :, or :., :, :, ereo mna ana exveemea armn emo acom seenue,ncee a ssneeneomna ann an oneo o or anens:nnoram oren : or, werene amno ac seu n :, :, :, ences as seorn :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, : :, :, :, :, : or , :, :, :,n n accorance w:.eresenscosuree amno ac seuence oe s as seor :,:, :,:, :,:, :,:, : o:, :. r ereo mna ana exveemea armn emo acom seenue,ncee a ssneeneomna ann an oneo o or anens:nnoramen : or, werene amno ac s orn :, :, euences as seorn :, :, a:en, :, :, :, enn or anen:nn,oman ma: com or :. e s rsee amno ac seuence o n aen eoxremnar :, : or :. ereo maavee emomen,e sneoman ano or anennnramen : or am, wnoe arcen seuence asenen an one o s: o orn :, : or e amn:o ac seuence oe s as seorn n accorance . orn : weresenscosure,e amno ac seuence oe s as se : , :, :, :, :, :,, :, :, :, :, :,:,:,:,:,:,:,:,:,:, :,:,:,: or:, :.:, :, :, ereo mna ana exveemea armn emo acom seenu,e sneoman ano or anennnramen : or, wereneence as amenone acn s an one o s: o orn :, : euences as seorn :, , : , :, :, :, : : , :, :, :, :, :, ,:,:,:,:,:,:,:,:, :, :, :, :, :, : or :, enn:. e aen or anennnoman ma comrsee amno ac seuence o n a sen eoxremnar emom:en,,e sneo:man or ano :. ereo maavee amno ac seuence ase or anennnramen : or, werene amno ac sneeuenn acne o one o s: o orn :, e s as seornornn accorance: : w or ,eresen:s:cos.ure,e amno ac seuence oe s as se :, : , :, :, :, :, , :, :, :, : :, :, :, , :, :,, :,:,:, :,:, :,:,:,:,: r emo:m,en,e sn:eo,m oar , n an exema n ano o:. ereo maavee amno ac seuence asen r anennnramen : or, werene amnoe acn s aenue onncee os a s: o orn ,: s seorn :, : , :, :, :, :, :,:,:,:, , :,:,:,:,:, :,:,:,:,:,: :, :, :, :, : o , :, :, eo mna an exe r :. er mar emomen,e sneoman ano or anennnramen :ave ore am,n woe acren seeue anmceno as acen seeuenn acne o onee o s as ses:oro orn o :, :, :, :, :n, an one :,:,:,:,:,:,:, :, :, :, :, : :, :, :, , :, :, :, : ane amno:, :, :, :, or :, ac: se,uence oe:,s as seor:n an, one o: :, :, a:r em oromen,e: sn or , n an exem eoman a:. ereo maavee amno ac seue no or anennnramen : or, werene anmceno as aenen an one o s: o orn o :, : c seuence oe s as seorn an one :, , :, :, :, :,:,:,:,:,:,:,:, :, :, :, :, : or :, :, : :, :, or :,e amno ac seuen,ce oe:s, as seor:n, :, :, :, :, :, : an, one o:, ac s :, :, :, :, :,e amno :e,uence oe:,s as seo:r,n an one o:, :,:,:, :, :, :, : :, :, :, :, , :, :, :, :, or :,:,:,:,:, e amno ac: se,uence oe:,s as seor:n, an one : or :, an :, :, : o :, :, :, :, :, , :, :, :, , : :, :, :, :, :, :, , :, :, :, :, :, :, :, :. :, :, : or ereo mna ana exveemea armn emo acom seenue,ncee a ssneoman ano or anennnramen : or, werene amno ace sneeuenn acne o onee o ss: o orn :, ereo maaveea: as seorn n an exem armn em or o acom seenue,ncee: a ssn. eeneomna an ano or anennnramen : or , werene amno ac seuennce o one oe s as ses:oo orn :, ereo ma ana exveemea: rn n armn em or o acom seenue,ncee: a ssn. eeneomna ann an oneo o or anennnramen : or, werene amno a s: o orn :, : c seuence oe s as seornorn :, or : ane amno ac seuence oe s as se n an exe : or :. ereo maavmar emomen,e sneoman ano or anennnramen :e ore am, wnoe arcen seuence asenen an one o s: o orn :, :,e : am,no ac seue:nces as seorn :, , :, :, :,, :, : :, :, :, :, :, :, :, :, : :, :, :, :, :, , :, :, :, : or :. :, :, ereo mna an exemar emomen,e sneoman ano or anennnramen :ave ore am,n wo aecren seueence a asenen an one o s: o orn :, mno ac seuences as seor :, : or :.:n a s,ecc emo:m, :, :, seor en,e amno ac seuence oe s as nn an exemar: em oormen :. ereo maavee amno ac seue,ne sneoman ano or anennnramen : or, werene amceno as ace sneeuenn acne o onee o s as: o orn :, : ereo maavee amnm or s seorn n an exemar eo acom seenue,ncee: a ssn. eeneomna ann an oneo o or anens:nnoram oren : or, werene amno ac seuenc n :, :, :, :,es as se:or,n ::,, :,:, :, :, :, :, : :, :, :, :, :, :, , :, :, :, :, :. :, :, :, :, or ereo mna an exemar emomen,e sneoman ano or anennnramen :ave ore am, wnoe arcen seeu aenmce asenen an one o s: o orn :, no ac seuence oe s as seorn n an exema:r em oromen,e: s. ereo maavee amno ac seuence asneoman ano or anennnramen : or, werene amennoe acn a senu oennece os as seors: o orn :, :, :, :, n :, :, :, :, :,:, :, :, :, :, :, :,:, :, :, :, :, :,:, :,:,:,:,:,: :, :, :, :, :, , :, :, :, :, : :, :, ereo mna ana exveemea armn emo aco:m see onr ue,ncee a ssnee:om.an ano or anennnramen : or, werene amno acn seeuenn an one o s: o orn o ce oe s as seorn an one , :,:, :,:,:, : :, :, : :, :, , :, :, :, : :, :, :, :, :,, :,:, :,:,o:,:, :, : or : ane amno ac :, as seorn a seuence oe s :n, one o :,:,: :, :, :, n an exemar emome or :. ereo maave n,e sneoman ano or anennnramen : ore am,no ac seuence asenen an one o s: o orn o werene amno ac seuence oe s as seorn an one ::,, ::,, :,:,:, :, :, :, :, : :, :, or : , :, :, : :, ,:,:,:,:,:,:, :, :, : : or :,e amno ac s:, s as seorn an euence oe :, :, one o :,:,: o:, :, seuence oe s as seorn an one o r:, :,e amno ac :, :, : :, :, :, :, , :, :, :, :,:,:,:,:,:,:,:, :, ence o:,:,:,:, :, :, :, seu : or : ane amno ac :e, s as s:e,orn an one: o, ::, :, :, :, :, : , :, : , :, :, :, :, ,:,:,:,:,: :, :, ,:, : , :, :, : , :, :, :, :,:,:,:,:,:, :, :, : or comrsn an amn o: :, :, n an asec e.resenscosure, sneoman ano varansncueoseoe amno ac soe aucenc see ouencee a aneasenn,n,oman,s, varae, reo,n or, snenca anoes exemee eoman an amno acer ex seemuenacre er amen eo. asmens oen sncaeoomea anm annoo ac v saeraunenscenc seueorosen c aonm ornsen o :,s:-,: s:-, s:-, :, :, ,:,:,:,:,: :, :, :, :, : , :, : , :, :, :, :, ,:,:,:,:,: :, :, :, : , :, :, :, , :, :, :, :,:,:,:,:,:, :, :, :, :, :, :, : :, :, :, :, :, ,:,:,:,:,: :, :, :, :, :, ,:, or:, :.:, ereo cnom an erxseems ana arm enmo aocm seenu,enece s aneoman ano or anennnramen enca, aeas enca eas enca, aeas enca, aeas encao :.orea, aeas enca, aeas enca, aeas ramenereo comrses an amnor accua sre,uenece s aneeasoman anenoca, o ar aenaennn oren s enca ereo cnca om ano erxseems ana ar em:o.men,e sneoman ano or anennnramen enca, aeasmno acen sceau,e anceea aseasencaen, acae,a aseasencaen, aca, aeas encao :.orearcuar,e sneoman ano or a eas ramenereo comrses an amno ac seuen nennn orenca ce aeas enca, aeas enca ereon ano exemar em:o.men,e sneoman ano or anennnramen e cnomcar,s aese aans amno acen sceau,e anceea aseasenenca, aeas enca, aeas encao :.orearcuar, ca, aeas enca, aeas ramenereo comrse e sneoman ano or anennn oren s an amno ac seuence aeas enca, aeas enca ereo cnca om ano erxseems ana arm enm: o ao. cm sen,e sneoman ano or anennnramen enca, a euence aeas enca, aeas enca, aeas enca eas enca, aeas enca, aeas enca, aeas ra o :.orearcuar,e sneoman ano or anennn ormenencereo comrses an amno ac seuence aeas enca, aeas enca ereo cna om ano erxseems ana arm enm: o ao. cm seenu,enece s aneeasoman anencoa, a or aenasennennramen enca, aeas enca, aeas enca, aeas ca, aeas encao :.orearcuar,e sneoman enca, aeas ramenereo comrses an amno a ano or anennn orencao :. c seuence aeas enca, aeas enca ereo cnom an erxseems ana arm enmo aocm seenu,enece s aneoman ano or anennnramen enca, aeas enca eas enca, aeas enca, aeas encao :.orea, aeas enca, aeas enca, aeas ramenereo comrses an amnor accua sre,uenece s aneeasoman anenoca, o ar aenaennn oren s enca ereo cnca om ano erxseems ana ar em:o.men,e sneoman ano or anennnramen enca, aeasmno acen sceau,e anceea aseasencaen, acae,a aseasencaen, aca, aeas encao :.orearcuar,e sneoman ano or a eas ramenereo comrses an amno ac seuen nennn orenca ce aeas enca, aeas enca ereon ano exemar em:o.men,e sneoman ano or anennnramen e cnomcar,s aese aans amno acen sceau,e anceea aseasenenca, aeas enca, aeas encao :.orearcuar, ca, aeas enca, aeas ramenereo comrse e sneoman ano or anennn oren s an amno ac seuence aeas enca, aeas enca ereo cnca om ano erxseems ana arm enm: o ao. cm sen,e sneoman ano or anennnramen enca, a euence aeas enca, aeas enca, aeas enca eas enca, aeas enca, aeas enca, aeas ra o :.orearcuar,e sneoman ano or anennn ormenencereo comrses an amno ac seuence aeas enca, aeas enca ereo cna om ano erxseems ana arm enm: o ao. cm seenu,enece s aneeasoman anencoa, a or aenasennennramen enca, aeas enca, aeas enca, aeas ca, aeas encao :.orearcuar,e sneoman enca, aeas ramenereo comrses an amno a ano or anennn orencao :. c seuence aeas enca, aeas enca ereo cnom an erxseems ana arm enmo aocm seenu,enece s aneoman ano or anennnramen enca, aeas enca eas enca, aeas enca, aeas encao :.orea, aeas enca, aeas enca, aeas ramenereo comrses an amnor accua sre,uenece s aneeasoman anenoca, o ar aenaennn oren s enca ereo cnca om ano erxseems ana ar em:o.men,e sneoman ano or anennnramen enca, aeasmno acen sceau,e anceea aseasencaen, acae,a aseasencaen, aca, aeas encao :.orearcuar,e sneoman ano or a eas ramenereo comrses an amno ac seuen nennn orenca ce aeas enca, aeas enca ereon ano exemar em:o.men,e sneoman ano or anennnramen e cnomcar,s aese aans amno acen sceau,e anceea aseasenenca, aeas enca, aeas encao :.orearcuar, ca, aeas enca, aeas ramenereo comrse e sneoman ano or anennn oren s an amno ac seuence aeas enca, aeas enca ereo cnca om ano erxseems ana arm enm: o ao. cm sen,e sneoman ano or anennnramen enca, a euence aeas enca, aeas enca, aeas enca eas enca, aeas enca, aeas enca, aeas ra o :.orearcuar,e sneoman ano or anennn ormenencereo comrses an amno ac seuence aeas enca, aeas enca ereo cna om ano erxseems ana arm enm: o ao. cm seenu,enece s aneeasoman anencoa, a or aenasennennramen enca, aeas enca, aeas enca, aeas ca, aeas encao :.orearcuar,e sneoman enca, aeas ramenereo comrses an amno a ano or anennn orencao :. c seuence aeas enca, aeas enca ereo cnom an erxseems ana arm enmo aocm seenu,enece s aneoman ano or anennnramen enca, aeas enca eas enca, aeas enca, aeas encao :.orea, aeas enca, aeas enca, aeas ramenereo comrses an amnor accua sre,uenece s aneeasoman anenoca, o ar aenaennn oren s enca ereo cnca om ano erxseems ana ar em:o.men,e sneoman ano or anennnramen enca, aeasmno acen sceau,e anceea aseasencaen, acae,a aseasencaen, aca, aeas encao :.orearcuar,e sneoman ano or a eas ramenereo comrses an amno ac seuen nennn orenca ce aeas enca, aeas enca ereon ano exemar em:o.men,e sneoman ano or anennnramen e cnomcar,s aese aans amno acen sceau,e anceea aseasenenca, aeas enca, aeas encao :.orearcuar, ca, aeas enca, aeas ramenereo comrse e sneoman ano or anennn oren s an amno ac seuence aeas enca, aeas enca ereo cnca om ano erxseems ana arm enm: o ao. cm sen,e sneoman ano or anennnramen enca, a euence aeas enca, aeas enca, aeas enca eas enca, aeas enca, aeas enca, aeas ra o :.orearcuar,e sneoman ano or anennn ormenencereo comrses an amno ac seuence aeas enca, aeas enca ereo cna om ano erxseems ana arm enm: o ao. cm seenu,enece s aneeasoman anencoa, a or aenasennennramen enca, aeas enca, aeas enca, aeas ca, aeas encao :.orearcuar,e sneoman enca, aeas ramenereo comrses an amno a ano or anennn orencao :. c seuence aeas enca, aeas enca ereo cnom an erxseems ana arm enmo aocm seenu,enece s aneeoman ano or anennnramen enca, aeas enca, as enca, aeas enca, aeas encao :.orear aceas enca, aeas enca, aeas ramenereo comrses ma comrsuea arn a,meno sn ace seomuaennce an aeoas or aneenncnn enca orencao a, aeas n an exemar emomen:. ereo comrse ,e sneoman ano or anennnramen enca, aeass ma coemncras,e a ane aamsno ace snecuaen,c ae aeaseas enencaca, aeas enca, aeas encao :.orearcuar,e sn, aeas or anennnramenereo comrses an a eoman anoeas enca orenc mno ac seuence aeas enca, a ereo cnom an erxseems ana arm enmo aoa cmo seenu,enec sn:e.oman ano or anennnramen enca, aeas enc e aeas enca, aeas enca, aeas encao :.orea, aeas enca, aeas enca, aeas ramenere arcuar,e sneoman ano or anennn oren o comrses an amno ac seuence aeas enca, aeas enca ereo cnca om ano erxseems ana ar em:o.men,e sneoman ano or anennnramen e mno ac seuence aeas enca, aeas enca, aeas encanoca, aeas:.eonrecaa,r acueaasr,e sennecao,m aaena asno oern anca,e aneas ramenereo comrses an amno ac seuence a nn oren eas enca, aeas enca nca ano exemar e:. ereo comrses an amnmo aocm seenu,enece s aneeasoman anencoa, a or aenasennnramen enca, aeas enca, aeas enca, ae enca, aeas encao :.orearcuar,e sneomaas enca, aeas ramenereo comrses an amno n ano or anennn orencao :. ac seuence aeas enca, aeas enca ereo cnom an erxseems ana arm enmo aocm seenu,enece s aneoman ano or anennnramen enca, aeas enca eas enca, aeas enca, aeas encao :.orea, aeas enca, aeas enca, aeas ramenereo comrses an amnor accua sre,uenece s aneeasoman anenoca, o ar aenaennn oren s enca ereo cnca om ano erxseems ana ar em:o.men,e sneoman ano or anennnramen enca, aeasmno acen sceau,e anceea aseasencaen, acae,a aseasencaen, aca, aeas encao :.orearcuar,e sneoman ano or a eas ramenereo comrses an amno ac seuen nennn orenca ce aeas enca, aeas enca ereon ano exemar em:o.men,e sneoman ano or anennnramen e cnomcar,s aese aans amno acen sceau,e anceea aseasenenca, aeas enca, aeas encao :.orearcuar, ca, aeas enca, aeas ramenereo comrse e sneoman ano or anennn oren s an amno ac seuence aeas enca, aeas enca ereo cnca om ano erxseems ana arm enm: o ao. cm sen,e sneoman ano or anennnramen enca, a euence aeas enca, aeas enca, aeas enca eas enca, aeas enca, aeas enca, aeas ra o :.orearcuar,e sneoman ano or anennn ormenencereo comrses an amno ac seuence aeas enca, aeas enca ereo cna om ano erxseems ana arm enm: o ao. cm seenu,enece s aneeasoman anencoa, a or aenasennennramen enca, aeas enca, aeas enca, aeas ca, aeas encao :.orearcuar,e sneoman enca, aeas ramenereo comrses an amno a ano or anennn orencao :. c seuence aeas enca, aeas enca ereo cnom an erxseems ana arm enmo aocm seenu,enece s aneoman ano or anennnramen enca, aeas enca eas enca, aeas enca, aeas encao :.orea, aeas enca, aeas enca, aeas ramenereo comrses an amnor accua sre,uenece s aneeasoman anenoca, o ar aenaennn oren s enca ereo cnca om ano erxseems ana ar em:o.men,e sneoman ano or anennnramen enca, aeasmno acen sceau,e anceea aseasencaen, acae,a aseasencaen, aca, aeas encao :.orearcuar,e sneoman ano or a eas ramenereo comrses an amno ac seuen nennn orenca ce aeas enca, aeas enca ereon ano exemar em:o.men,e sneoman ano or anennnramen e cnomcar,s aese aans amno acen sceau,e anceea aseasenenca, aeas enca, aeas encao :.orearcuar, ca, aeas enca, aeas ramenereo comrse e sneoman ano or anennn oren s an amno ac seuence aeas enca, aeas enca ereo cnca om ano erxseems ana arm enm: o ao. cm seene sneoman ano or anennnramen enca, ae uence aeas enca, aeas enca, aeas encao as enca, aeas enca, aeas enca, aeas ram :.orearcuar,e sneoman ano or anennn orenencereo comrses an amno ac seuence aeas enca, aeas enca ereo cna om ano erxseems ana arm enm: o ao. cm seenu,enece s aneeasoman anencoa, a or aenasennennramen enca, aeas enca, aeas enca, aeas ca, aeas encao :.orearcuar,e sneoman enca, aeas ramenereo comrses an amno a ano or anennn orencao :. c seuence aeas enca, aeas enca ereo cnom an erxseems ana arm enmo aocm seenu,enece s aneoman ano or anennnramen enca, aeas enca eas enca, aeas enca, aeas encao :.ore,a aeas enca, aeas enca, aeas ramenereo comrses an amno arccu saeru,encee s aneaesoman aenncoa, a ore aanennn oren s enca ereo cnca om ano erxseems ana ar em:o.men,e sneoman ano or anennnramen enca, aeasmno acen sceau,e anceea aseasencaen, acae,a aseasencaen, aca, aeas encao :.orearcuar,e sneoman ano or a eas ramenereo comrses an amno ac seuen nennn orenca ce aeas enca, aeas enca ereon ano exemar em:o.men,e sneoman ano or anennnramen e cnomcar,s aese aans amno acen sceau,e anceea aseasenenca, aeas enca, aeas encao :.orearcuar, ca, aeas enca, aeas ramenereo comrse e sneoman ano or anennn oren s an amno ac seuence aeas enca, aeas enca ereo cnca om ano erxseems ana arm enm: o ao. cm sen,e sneoman ano or anennnramen enca, a euence aeas enca, aeas enca, aeas enca eas enca, aeas enca, aeas enca, aeas ra o :.orearcuar,e sneoman ano or anennn ormenencereo comrses an amno ac seuence aeas enca, aeas enca ereo cna om ano erxseems ana arm enm: o ao. cm seenu,enece s aneeasoman anencoa, a or aenasennennramen enca, aeas enca, aeas enca, aeas ca, aeas encao :.orearcuar,e sneoman enca, aeas ramenereo comrses an amno a ano or anennn orencao :. c seuence aeas enca, aeas enca ereo cnom an erxseems ana arm enmo aocm seenu,enece s aneoman ano or anennnramen enca, aeas enca eas enca, aeas enca, aeas encao :.ore,a aeas enca, aeas enca, aeas ramenereo comrses an amno arccu saeru,encee s aneaesoman aenncoa, a ore aanennn oren s enca ereo cnca om ano erxseems ana ar em:o.men,e sneoman ano or anennnramen enca, aeasmno acen sceau,e anceea aseasencaen, acae,a aseasencaen, aca, aeas encao :.orearcuar,e sneoman ano or a eas ramenereo comrses an amno ac seuen nennn orenca ce aeas enca, aeas enca ereon ano exemar em:o.men,e sneoman ano or anennnramen e cnomcar,s aese aans amno acen sceau,e anceea aseasenenca, aeas enca, aeas encao :.orearcuar, ca, aeas enca, aeas ramenereo comrse e sneoman ano or anennn oren s an amno ac seuence aeas enca, aeas enca ereo cnca om ano erxseems ana arm enm: o ao. cm sen,e sneoman ano or anennnramen enca, a euence aeas enca, aeas enca, aeas enca eas enca, aeas enca, aeas enca, aeas ra o :.orearcuar,e sneoman ano or anennn ormenencereo comrses an amno ac seuence aeas enca, aeas enca ereo cna om ano erxseems ana arm enm: o ao. cm seenu,enece s aneeasoman anencoa, a or aenasennennramen enca, aeas enca, aeas enca, aeas ca, aeas encao :.orearcuar,e sneoman enca, aeas ramenereo comrses an amno a ano or anennn orencao :. c seuence aeas enca, aeas enca ereo cnom an erxseems ana arm enmo aocm seenu,enece s aneoman ano or anennnramen enca, aeas enca eas enca, aeas enca, aeas encao :.ore,a aeas enca, aeas enca, aeas ramenereo comrses an amno arccu saeru,encee s aneaesoman aenncoa, a ore aanennn oren s enca ereo cnca om ano erxseems ana ar em:o.men,e sneoman ano or anennnramen enca, aeasmno acen sceau,e anceea aseasencaen, acae,a aseasencaen, aca, aeas encao :.orearcuar,e sneoman ano or a eas ramenereo comrses an amno ac seuen nennn orenca ce aeas enca, aeas enca ereon ano exemar em:o.men,e sneoman ano or anennnramen e cnomcar,s aese aans amno acen sceau,e anceea aseasenenca, aeas enca, aeas encao :.orearcuar, ca, aeas enca, aeas ramenereo comrse e sneoman ano or anennn oren s an amno ac seuence aeas enca, aeas enca ereo cnca om ano erxseems ana arm enm: o ao. cm sen,e sneoman ano or anennnramen enca, a euence aeas enca, aeas enca, aeas enca eas enca, aeas enca, aeas enca, aeas ra o :.orearcuar,e sneoman ano or anennn ormenencereo comrses an amno ac seuence aeas enca, aeas enca ereo cna om ano erxseems ana arm enm: o ao. cm seenu,enece s aneeasoman anencoa, a or aenasennennramen enca, aeas enca, aeas enca, aeas ca, aeas encao :.orearcuar,e sneoman enca, aeas ramenereo comrses an amno a ano or anennn orencao :. c seuence aeas enca, aeas enca ereo cnom an erxseems ana arm enmo aocm seenu,enece s aneoman ano or anennnramen enca, aeas enca eas enca, aeas enca, aeas encao :.ore,a aeas enca, aeas enca, aeas ramenereo comrses an amno arccu saeru,encee s aneaesoman aenncoa, a ore aanennn oren s enca ereo cnca om ano erxseems ana ar em:o.men,e sneoman ano or anennnramen enca, aeasmno acen sceau,e anceea aseasencaen, acae,a aseasencaen, aca, aeas encao :.orearcuar,e sneoman ano or a eas ramenereo comrses an amno ac seuen nennn orenca ce aeas enca, aeas enca ereon ano exemar em:o.men,e sneoman ano or anennnramen e cnomcar,s aese aans amno acen sceau,e anceea aseasenenca, aeas enca, aeas encao :.orearcuar, ca, aeas enca, aeas ramenereo comrse e sneoman ano or anennn oren s an amno ac seuence aeas enca, aeas enca ereo cnca om ano erxseems ana arm enm: o ao. cm sen,e sneoman ano or anennnramen enca, a euence aeas enca, aeas enca, aeas enca eas enca, aeas enca, aeas enca, aeas ra o :.orearcuar,e sneoman ano or anennn ormenencereo comrses an amno ac seuence aeas enca, aeas enca ereo cna om ano erxseems ana arm enm: o ao. cm seenu,enece s aneeasoman anencoa, a or aenasennennramen enca, aeas enca, aeas enca, aeas ca, aeas encao :.orearcuar,e sneoman enca, aeas ramenereo comrses an amno a ano or anennn orencao :. c seuence aeas enca, aeas enca ereo cnom an erxseems ana arm enmo aocm seenu,enece s aneoman ano or anennnramen enca, aeas enca eas enca, aeas enca, aeas encao :.ore,a aeas enca, aeas enca, aeas ramenereo comrses an amno arccu saeru,encee s aneaesoman aenncoa, a ore aanennn oren s enca ereo cnca om ano erxseems ana ar em:o.men,e sneoman ano or anennnramen enca, aeasmno acen sceau,e anceea aseasencaen, acae,a aseasencaen, aca, aeas encao :.orearcuar,e sneoman ano or a eas ramenereo comrses an amno ac seuen nennn orenca ce aeas enca, aeas enca ereon ano exemar em:o.men,e sneoman ano or anennnramen e cnomcar,s aese aans amno acen sceau,e anceea aseasenenca, aeas enca, aeas encao :.orearcuar, ca, aeas enca, aeas ramenereo comrse e sneoman ano or anennn oren s an amno ac seuence aeas enca, aeas enca ereo cnca om ano erxseems ana arm enm: o ao. cm sen,e sneoman ano or anennnramen enca, a euence aeas enca, aeas enca, aeas enca eas enca, aeas enca, aeas enca, aeas ra o :.orearcuar,e sneoman ano or anennn ormenencereo comrses an amno ac seuence aeas enca, aeas enca ereo cna om ano erxseems ana arm enm: o ao. cm seenu,enece s aneeasoman anencoa, a or aenasennennramen enca, aeas enca, aeas enca, aeas ca, aeas encao :.orearcuar,e sneoman enca, aeas ramenereo comrses an amno a ano or anennn orencao :. c seuence aeas enca, aeas enca ereo cnom an erxseems ana arm enmo aocm seenu,enece s aneoman ano or anennnramen enca, aeas enca eas enca, aeas enca, aeas encao :.ore,a aeas enca, aeas enca, aeas ramenereo comrses an amno arccu saeru,encee s aneaesoman aenncoa, a ore aanennn oren s enca ereo cnca om ano erxseems ana ar em:o.men,e sneoman ano or anennnramen enca, aeasmno acen sceau,e anceea aseasencaen, acae,a aseasencaen, aca, aeas encao :.orearcuar,e sneoman ano or a eas ramenereo comrses an amno ac seuen nennn orenca ce aeas enca, aeas enca ereon ano exemar em:o.men,e sneoman ano or anennnramen e cnomcar,s aese aans amno acen sceau,e anceea aseasenenca, aeas enca, aeas encao :.orearcuar, ca, aeas enca, aeas ramenereo comrse e sneoman ano or anennn oren s an amno ac seuence aeas enca, aeas enca ereo cnca om ano erxseems ana arm enm: o ao. cm sen,e sneoman ano or anennnramen enca, a euence aeas enca, aeas enca, aeas enca eas enca, aeas enca, aeas enca, aeas ra o :.orearcuar,e sneoman ano or anennn ormenencereo comrses an amno ac seuence aeas enca, aeas enca ereo cna om ano erxseems ana arm enm: o ao. cm seenu,enece s aneeasoman anencoa, a or aenasennennramen enca, aeas enca, aeas enca, aeas ca, aeas encao :.orearcuar,e sneoman enca, aeas ramenereo comrses an amno a ano or anennn orencao :. c seuence aeas enca, aeas enca ereo cnom an erxseems ana arm enmo aocm seenu,enece s aneeaoman ano or anennnramen enca, aeas enca, ae s enca, aeas enca, aeas encao :.orearcuasa enca, aeas enca, aeas orramenenereo comrses an amno ac seru,encee s aneaesoman aenncoa, a ore aansennennca ereo cnca om ano erxseems ana arm enm: o ao. cm seen,e sneoman ano or anennnramen enca, ae uence aeas enca, aeas enca, aeas encao as:enca, aeas enca, aeas enca, aeas ramenereo comrses a.n aomrenoa arccu saeru,encee s aneaesoman aenncoa, or anennn orencao :. aeas enca ereo cnom an erxseems anar emomen,e sneoman ano or anennnramen enca, aeas amno acen sceau,e anceea aseasencaen, acae,a aseasencaen, acae,a aeas encao :.orearcuar,e sneoman ano or anes ramenereo comrses an amno ac seuence a nnn oren eas enca, aeas enca nca ano exemar e:. ereo c momen,e sneoman ano or anennnramen enomcar,s aese aans amno acen sceau,e anceea aseasencaen, acae,a aeas enca, aeas encao :.orearcuar,e sneomans enca, aeas ramenereo comrses an amno ac ano or anennn oren seuence aeas enca, aeas enca ereo cnca om ano erxseems ana arm enm: o ao. cm seenu,enece s aneeasoman aneo or anennnramen enca, aeas enca, aeas nca, aeas enca, aeas encao :.orearcuar,enca, aeas enca, aeas ramenereo comrses e sneoman ano or anennn orencao : an a.mn anno e axcem searuen ecme aoemasen,e sennecao,m aaenas anoe onrca aenasennenncraa,m aeneasereo coemncrase,s a ane amno ac seuence aeas enca, a enca, aeas enca as enca, aeas enca, aeas ano or anennnr o :.orearcuar,e sneoman enca, aeas encaa omrenereo comrses an amno ac seuence aeas n an exemar e encao :. ereo comrses an amnmo aocm seenu,enece s aneeasoman anencoa, a or anennnramen enca, aeas enca, aeas enc eas enca, aeas encao :.orearcuar,e a, aeas enca, aeas orramenenereo comrses an amno ac seuence s aneaesoman aenncoa, a ore aansennennca ereo cnca om ano erxseems ana arm enm: oo.men,e sneoman ano or anennnramen enca, aeas acen sceau,e anceea aseasencaen, acae,a aseasencaen, acae,a aeas encao :.orearcuar,e sneoman ano or an s ramenereo comrses an amno ac seuen ennn orenc ce aeas enca, aeas enca ereo cna om ano erxseems ana arm enm: o ao. cm seenu,enece s aneeasoman aneo or anennnramen enca, aeas enca, ae nca, aeas enca, aeas encao :.orearcas enca, aeas enca, aeas ramenereo c uar,e sneoman ano or anennn oren omrses an amno ac seuence aeas enca, aeas enca ereo cnca om ano erxseems ana arm enm: o ao. cm seenu,enece s aneeasoman anencoa, a or aenasennenncara, amen enca, aeas enca, aeas enca, aeas enc eas encao :.orearcuar,e sneoman an a, aeas ramenereo comrses an amno ac o or anennn orencao :. seuence aeas enca, aeas enca ereo cnom an erxseems ana arm enmo aocm seenu,enece s aneoman ano or anennnramen enca, aeas enca eas enca, aeas enca, aeas encao :.ore,a aeas enca, aeas enca, aeas ramenereo comrses an amno arccu saeru,encee s aneaesoman aenncoa, a ore aanennn oren s enca ereo cnca om ano erxseems ana ar em:o.men,e sneoman ano or anennnramen enca, aeasmno acen sceau,e anceea aseasencaen, acae,a aseasencaen, aca, aeas encao :.orearcuar,e sneoman ano or a eas ramenereo comrses an amno ac seuen nennn orenca ce aeas enca, aeas enca ereon ano exemar em:o.men,e sneoman ano or anennnramen e cnomcar,s aese aans amno acen sceau,e anceea aseasenenca, aeas enca, aeas encao :.orearcuar, ca, aeas enca, aeas ramenereo comrse e sneoman ano or anennn oren s an amno ac seuence aeas enca, aeas enca ereo cnca om ano erxseems ana arm enm: o ao. cm sen,e sneoman ano or anennnramen enca, a euence aeas enca, aeas enca, aeas enca eas enca, aeas enca, aeas enca, aeas ra o :.orearcuar,e sneoman ano or anennn ormenencereo comrses an amno ac seuence aeas enca, aeas enca ereo cna om ano erxseems ana arm enm: o ao. cm seenu,enece s aneeasoman anencoa, a or aenasennennramen enca, aeas enca, aeas enca, aeas ca, aeas encao :.orearcuar,e sneoman enca, aeas ramenereo comrses an amno a ano or anennn orencao :. c seuence aeas enca, aeas enca ereo cnom an erxseems ana arm enmo aocm seenu,enece s aneoman ano or anennnramen enca, aeas enca eas enca, aeas enca, aeas encao :.ore,a aeas enca, aeas enca, aeas ramenereo comrses an amno arccu saeru,encee s aneaesoman aenncoa, a ore aanennn oren s enca ereo cnca om ano erxseems ana ar em:o.men,e sneoman ano or anennnramen enca, aeasmno acen sceau,e anceea aseasencaen, acae,a aseasencaen, aca, aeas encao :.orearcuar,e sneoman ano or a eas ramenereo comrses an amno ac seuen nennn orenca ce aeas enca, aeas enca ereon ano exemar em:o.men,e sneoman ano or anennnramen e cnomcar,s aese aans amno acen sceau,e anceea aseasenenca, aeas enca, aeas encao :.orearcuar, ca, aeas enca, aeas ramenereo comrse e sneoman ano or anennn oren s an amno ac seuence aeas enca, aeas enca ereo cnca om ano erxseems ana arm enm: o ao. cm sen,e sneoman ano or anennnramen enca, a euence aeas enca, aeas enca, aeas enca eas enca, aeas enca, aeas enca, aeas ra o :.orearcuar,e sneoman ano or anennn ormenencereo comrses an amno ac seuence aeas enca, aeas enca ereo cna om ano erxseems ana arm enm: o ao. cm seenu,enece s aneeasoman anencoa, a or aenasennennramen enca, aeas enca, aeas enca, aeas ca, aeas encao :.orearcuar,e sneoman enca, aeas ramenereo comrses an amno a ano or anennn orencao :. c seuence aeas enca, aeas enca ereo cnom an erxseems ana arm enmo aocm seenu,enece s aneoman ano or anennnramen enca, aeas enca eas enca, aeas enca, aeas encao :.ore,a aeas enca, aeas enca, aeas ramenereo comrses an amno arccu saeru,encee s aneaesoman aenncoa, a ore aanennn oren s enca ereo cnca om ano erxseems ana ar em:o.men,e sneoman ano or anennnramen enca, aeasmno acen sceau,e anceea aseasencaen, acae,a aseasencaen, aca, aeas encao :.orearcuar,e sneoman ano or a eas ramenereo comrses an amno ac seuen nennn orenca ce aeas enca, aeas enca ereon ano exemar em:o.men,e sneoman ano or anennnramen e cnomcar,s aese aans amno acen sceau,e anceea aseasenenca, aeas enca, aeas encao :.orearcuar, ca, aeas enca, aeas ramenereo comrse e sneoman ano or anennn oren s an amno ac seuence aeas enca, aeas enca ereo cnca om ano erxseems ana arm enm: o ao. cm sen,e sneoman ano or anennnramen enca, a euence aeas enca, aeas enca, aeas enca eas enca, aeas enca, aeas enca, aeas ra o :.orearcuar,e sneoman ano or anennn ormenencereo comrses an amno ac seuence aeas enca, aeas enca ereo cna om ano erxseems ana arm enm: o ao. cm seenu,enece s aneeasoman anencoa, a or aenasennennramen enca, aeas enca, aeas enca, aeas ca, aeas encao :.orearcuar,e sneoman enca, aeas ramenereo comrses an amno a ano or anennn orencao :. c seuence aeas enca, aeas enca ereo cnom an erxseems ana arm enmo aocm seenu,enece s aneoman ano or anennnramen enca, aeas enca eas enca, aeas enca, aeas encao :.ore,a aeas enca, aeas enca, aeas ramenereo comrses an amno arccu saeru,encee s aneaesoman aenncoa, a ore aanennn oren s enca ereo cnca om ano erxseems ana ar em:o.men,e sneoman ano or anennnramen enca, aeasmno acen sceau,e anceea aseasencaen, acae,a aseasencaen, aca, aeas encao :.orearcuar,e sneoman ano or a eas ramenereo comrses an amno ac seuen nennn orenca ce aeas enca, aeas enca ereon ano exemar em:o.men,e sneoman ano or anennnramen e cnomcar,s aese aans amno acen sceau,e anceea aseasenenca, aeas enca, aeas encao :.orearcuar, ca, aeas enca, aeas ramenereo comrse e sneoman ano or anennn oren s an amno ac seuence aeas enca, aeas enca ereo cnca om ano erxseems ana arm enm: o ao. cm sen,e sneoman ano or anennnramen enca, a euence aeas enca, aeas enca, aeas enca eas enca, aeas enca, aeas enca, aeas ra o :.orearcuar,e sneoman ano or anennn ormenencereo comrses an amno ac seuence aeas enca, aeas enca ereo cna om ano erxseems ana arm enm: o ao. cm seenu,enece s aneeasoman anencoa, a or aenasennennramen enca, aeas enca, aeas enca, aeas ca, aeas encao :.orearcuar,e sneoman enca, aeas ramenereo comrses an amno a ano or anennn orencao :. c seuence aeas enca, aeas enca ereo cnom an erxseems ana arm enmo aocm seenu,enece s aneoman ano or anennnramen enca, aeas enca eas enca, aeas enca, aeas encao :.ore,a aeas enca, aeas enca, aeas ramenereo comrses an amno arccu saeru,encee s aneaesoman aenncoa, a ore aanennn oren s enca ereo cnca om ano erxseems ana ar em:o.men,e sneoman ano or anennnramen enca, aeasmno acen sceau,e anceea aseasencaen, acae,a aseasencaen, aca, aeas encao :.orearcuar,e sneoman ano or a eas ramenereo comrses an amno ac seuen nennn orenca ce aeas enca, aeas enca ereon ano exemar em:o.men,e sneoman ano or anennnramen e cnomcar,s aese aans amno acen sceau,e anceea aseasenenca, aeas enca, aeas encao :.orearcuar, ca, aeas enca, aeas ramenereo comrse e sneoman ano or anennn oren s an amno ac seuence aeas enca, aeas enca ereo cnca om ano erxseems ana arm enm: o ao. cm sen,e sneoman ano or anennnramen enca, a euence aeas enca, aeas enca, aeas enca eas enca, aeas enca, aeas enca, aeas ra o :.orearcuar,e sneoman ano or anennn ormenencereo comrses an amno ac seuence aeas enca, aeas enca ereo cna om ano erxseems ana arm enm: o ao. cm seenu,enece s aneeasoman anencoa, a or aenasennennramen enca, aeas enca, aeas enca, aeas ca, aeas encao :.orearcuar,e sneoman enca, aeas ramenereo comrses an amno a ano or anennn orencao :. c seuence aeas enca, aeas enca ereo cnom an erxseems ana arm enmo aocm seenu,enece s aneoman ano or anennnramen enca, aeas enca eas enca, aeas enca, aeas encao :.ore,a aeas enca, aeas enca, aeas ramenereo comrses an amno arccu saeru,encee s aneaesoman aenncoa, a ore aanennn oren s enca ereo cnca om ano erxseems ana ar em:o.men,e sneoman ano or anennnramen enca, aeasmno acen sceau,e anceea aseasencaen, acae,a aseasencaen, aca, aeas encao :.orearcuar,e sneoman ano or a eas ramenereo comrses an amno ac seuen nennn orenca ce aeas enca, aeas enca ereon ano exemar em:o.men,e sneoman ano or anennnramen e cnomcar,s aese aans amno acen sceau,e anceea aseasenenca, aeas enca, aeas encao :.orearcuar, ca, aeas enca, aeas ramenereo comrse e sneoman ano or anennn oren s an amno ac seuence aeas enca, aeas enca ereo cnca om ano erxseems ana arm enm: o ao. cm sen,e sneoman ano or anennnramen enca, a euence aeas enca, aeas enca, aeas enca eas enca, aeas enca, aeas enca, aeas ra o :.orearcuar,e sneoman ano or anennn ormenencereo comrses an amno ac seuence aeas enca, aeas enca ereo cna om ano erxseems ana arm enm: o ao. cm seenu,enece s aneeasoman anencoa, a or aenasennennramen enca, aeas enca, aeas enca, aeas ca, aeas encao :.orearcuar,e sneoman enca, aeas ramenereo comrses an amno a ano or anennn orencao :. c seuence aeas enca, aeas enca ereo cnom an erxseems ana arm enmo aocm seenu,enece s aneoman ano or anennnramen enca, aeas enca eas enca, aeas enca, aeas encao :.ore,a aeas enca, aeas enca, aeas ramenereo comrses an amno arccu saeru,encee s aneaesoman aenncoa, a ore aanennn oren s enca ereo cnca om ano erxseems ana ar em:o.men,e sneoman ano or anennnramen enca, aeasmno acen sceau,e anceea aseasencaen, acae,a aseasencaen, aca, aeas encao :.orearcuar,e sneoman ano or a eas ramenereo comrses an amno ac seuen nennn orenca ce aeas enca, aeas enca ereon ano exemar em:o.men,e sneoman ano or anennnramen e cnomcar,s aese aans amno acen sceau,e anceea aseasenenca, aeas enca, aeas encao :.orearcuar, ca, aeas enca, aeas ramenereo comrse e sneoman ano or anennn oren s an amno ac seuence aeas enca, aeas enca ereo cnca om ano erxseems ana arm enm: o ao. cm sen,e sneoman ano or anennnramen enca, a euence aeas enca, aeas enca, aeas enca eas enca, aeas enca, aeas enca, aeas ra o :.orearcuar,e sneoman ano or anennn ormenencereo comrses an amno ac seuence aeas enca, aeas enca ereo cna om ano erxseems ana arm enm: o ao. cm seenu,enece s aneeasoman anencoa, a or aenasennennramen enca, aeas enca, aeas enca, aeas ca, aeas encao :.orearcuar,e sneoman enca, aeas ramenereo comrses an amno a ano or anennn orencao :. c seuence aeas enca, aeas enca ereo cnom an erxseems ana arm enmo aocm seenu,enece s aneoman ano or anennnramen enca, aeas enca eas enca, aeas enca, aeas encao :.ore,a aeas enca, aeas enca, aeas ramenereo comrses an amno arccu saeru,encee s aneaesoman aenncoa, a ore aanennn oren s enca ereo cnca om ano erxseems ana ar em:o.men,e sneoman ano or anennnramen enca, aeasmno acen sceau,e anceea aseasencaen, acae,a aseasencaen, aca, aeas encao :.orearcuar,e sneoman ano or a eas ramenereo comrses an amno ac seuen nennn orenca ce aeas enca, aeas enca ereon ano exemar em:o.men,e sneoman ano or anennnramen e cnomcar,s aese aans amno acen sceau,e anceea aseasenenca, aeas enca, aeas encao :.orearcuar, ca, aeas enca, aeas ramenereo comrse e sneoman ano or anennn oren s an amno ac seuence aeas enca, aeas enca ereo cnca om ano erxseems ana arm enm: o ao. cm sen,e sneoman ano or anennnramen enca, a euence aeas enca, aeas enca, aeas enca eas enca, aeas enca, aeas enca, aeas ra o :.orearcuar,e sneoman ano or anennn ormenencereo comrses an amno ac seuence aeas enca, aeas enca ereo cna om ano erxseems ana arm enm: o ao. cm seenu,enece s aneeasoman anencoa, a or aenasennennramen enca, aeas enca, aeas enca, aeas ca, aeas encao :.orearcuar,e sneoman enca, aeas ramenereo comrses an amno a ano or anennn orencao :. c seuence aeas enca, aeas enca ereo cnom an erxseems ana arm enmo aocm seenu,enece s aneoman ano or anennnramen enca, aeas enca eas enca, aeas enca, aeas encao :.ore,a aeas enca, aeas enca, aeas ramenereo comrses an amno arccu saeru,encee s aneaesoman aenncoa, a ore aanennn oren s enca ereo cnca om ano erxseems ana ar em:o.men,e sneoman ano or anennnramen enca, aeasmno acen sceau,e anceea aseasencaen, acae,a aseasencaen, aca, aeas encao :.orearcuar,e sneoman ano or a eas ramenereo comrses an amno ac seuen nennn orenca ce aeas enca, aeas enca ereon ano exemar em:o.men,e sneoman ano or anennnramen e cnomcar,s aese aans amno acen sceau,e anceea aseasenenca, aeas enca, aeas encao :.orearcuar, ca, aeas enca, aeas ramenereo comrse e sneoman ano or anennn oren s an amno ac seuence aeas enca, aeas enca ereo cnca om ano erxseems ana arm enm: o ao. cm sen,e sneoman ano or anennnramen enca, a euence aeas enca, aeas enca, aeas enca eas enca, aeas enca, aeas enca, aeas ra o :.orearcuar,e sneoman ano or anennn ormenencereo comrses an amno ac seuence aeas enca, aeas enca ereo cna om ano erxseems ana arm enm: o ao. cm seenu,enece s aneeasoman anencoa, a or aenasennennramen enca, aeas enca, aeas enca, aeas ca, aeas encao :.orearcuar,e sneoman enca, aeas ramenereo comrses an amno a ano or anennn orencao :. c seuence aeas enca, aeas enca ereo cnom an erxseems ana arm enmo aocm seen,e sneoman ano or anennnramen enca, aeas encau,e anceea aseasencaen, acae,a aseasencaen, acae,a aeas encao :.orearcuar,e sneoman ano or s ramenereo comrses an amno ac s anennn orencao : euence aeas enca, aeas enca ereo cnom anr exseesm anar am enmo ao. cm sen,e sneoman ano or anennnramen amno ac seuenc euence aeas , ,, encaoe ereo cnom anr exseesme ana sre a eomronmen,e sn:.eoman ano or anennnramen amno ac mno ac seuence aeas , ,, encaoe n a sne exueemncea sre eomronmen,e:. amerneoo a ccomrses an amno ac seuence s aneeasoman, ano o,r an,ennenncaraomene n a sne exueemncea sre eorn :. e momen,e sneoman ano or anennnramen amrneoo a ccom serses an amno ac seuence aeas , ,, encaoe n an euence seorn :. ereo comrxseesm anar am enmo aocm seen,uenece sneoman ano or anennnramen amno ac seuence seorn aeas , ,, encaoe ereo cnom anr exseesm anar am enmo aocm sen,e sn:.eoman ano or anennnramen amno ac seuenc euence aeas , ,, encaoe ereo cnom anr exseesme ana sre a eomronmen,e sn:.eoman ano or anennnramen amno ac mno ac seuence aeas , ,, encaoe n a sne exueemncea sre eomronmen,e:. ereo comrses an amno ac seuence s aneeasoman, ano o,r an,ennenncaraomene a amnnoo ac or s aenueennce snenorranmen :.n an exemar emomen,e sneoman ,, encaoe amno aecreo comrses an amno ac seuence aeas , n seuence seorn :. seuence a oeears exem,ar emo,men,s,ee snnceoman ano comrses an amno ac : aoe amno ac seuence seorn seuencen a o. eears exem,ar emo,men,s,ee snncaeoomaen am anno comrses an amno ac : o ac seuence seorn seuencen a o. eears exem,ar emo,men,s,ee snncaeoomaen am anno aoc s ceomurses an amno ac :. ence seorn seuenn oer exemar emomens,e sneoman ano comrses an amno ac :ce aeas , ,, encaoe amno ac seuence seorn seuencen a o. eears exem,ar emomens,e sneoman ano comrses an amno ac : ,, encaoe amno ac seuence seorn n o. seuence aeears exem,ar emo,men,s,ee snncaeoman ano comrses an amno ac :. oe amno ac seuence seorn ramenn acecreoora oncee wresenerecsoesnures mcaosure,e sneoman ano or anennn e comrse a seuence maerome comnaon o reonacones oav anveen am snnoe acom saenu anoscoseeren aneav can varae n accorance weresenscence seorn :. ramen osure,e sneoman ano or anennn oe ereo os oe arevseenn sncseosuore ma comrse a seuence maerome comnaon reonaconeavne amno ac smeaunen acne seoorscnoseeren a:n.eav can varae amno acn ac sceorueannccee a weasere,senscos,ure,e sneenomcaano aneo amn ma comrse an comnaon o o ac seuence amno acn ac sceoruaancee w.eresenscosuree sneoman ano ma comrsee seuence aeasence coemncnaaoon oae: an amerzaonomana comrses a a : oro :, an oonao : anoro oonao : anor ao seuence a:eas, c a seencao : an : oro :, a seuence aeasuenecne acaeaos en:cao or e swan o eemens o a a , n accorance weresnen. ramenereo c scosure,e sneoman ano or anennn osons,oem amrnsoes ac a se reusenucee a aso sesoonresren,, we aemrenno ae amno ac resue as,e amno ac resue aosons,e amno c resue aoson amno ac resue aosons,e amn ac resue aosons,e resue aoson s,e am o ac resue aosons,e amno ac oson s,e am no ac resue aoson s,e amno ac resue a s,e a no ac resue aoson s,e amno ac resue aoson e mno ac resue aoson s,e amno ac resue aoson s, ac am resnou aec a reossuoen aos anonoresos,oen asm wno a rceer reensceueo aoson s,e amno n accorance weresenscosure,e sneoman : ae. ramenereo comrses a seuence as ano or anennn osons,e amn seoreren, werene amno ac resue a ,e amn o ac resue aosons,e amno ac resue aosons ac resueo a acos resonue asos,oen amnso ac,e re asmuneo a acos resonue asos,oen as,e amno aosons,e amno ac resue aosons,e mno ac resue s,e amno ac resue aoson s,e amno ac resue aoson e amno ac resue aoson s, amno ac resue aoson s, ac resue aosons e amno ac resue aoson s,e amno aoson s,e amno a,ce r aemsnuoe a aco ressoune aoss,one amsno, ace a rmesnoue ac a roessoune s asn,ee aomsnoon acs resue aosons anore amno ac resue aoson n ac w reerenceo : ae. ramenecroeroan cocem wrses ae seresueennces acsosure,e sneoman ano or anennn osons,e amno ac resue aos seonorse,reen, am wneore acn rees amuen ao acos resue a e amno ac resue aosons,e amno ac resu ons, resue aosons,e amno ac e aosons,e amno ac osons,e amno ac resue ao ressoune asos,one amsno, ace a remsnoue a aco ressoune a asmn,o aec am rensou aec a reossuoen aosso,ne amsno, ace a rmeno ac resue aosons,e resue aoson s,e amn sue aosons,e amno ac oson s, o ac resue aoson s,e amno ac resue a s,e amno aec am renso auce a resosueo anosson,e asmn,o aec am renso auc resue aoson e amno ac resue aoson s,e amno a e aoson s, ac resue aosons, an c resue aosons,e amnos w reere ore amno ac resue aosons aneoson ra n accnocreaonce we:resenasceosure.,e onmseernvereo comrse sneoman ano or anennn c s a seuence as seoreren w amno ac susuons mrsna svoem oer e nmono conmservave. co ens,e sneoman ano or anennnramenereo aes a se aueonsceo ans s,eo arosereonn w, a amonso aocn su,s auoons seecerom: aoson, aoson, aoson, aossoonn,, aoson, aoson, aoson aoson, a aososonon,, a aoossoonn, ,, a aoossoonn,, a aoson, aoson, c aoson, aoson, aoson, aoossoon, aoson, aoson, aos n, aoson, ao on, aoson, aoson, aossoonn,, aoson, aoson, aoson, aoson, e a aoossoonn,, a aooson, aoson, aoson, a son, aoson, aososonon,, a aoossoonn,, a aoosson, aoson, aoson, aoson, aoson, aosoonn,, a aoossoonn,, a aoossoonn, aoso , a aoossoonn n,, , a aoson, aoson, aoson, aoson, aoson, aoossoonn, aoson, aos , aoson, aoson, aoson, aosoonn,, aoson, aoson, aoson, aoson, aoson aoson, aoson,, a aososonon,, a aoossoonn,, a aoson, aoson, aoson, aoson oson, aoson, aoson, aoson,, a aoossoon, aoson, aoson, aosonn,, a aoossoonn,, a aoossoonn,, a aos aooson soon, n, a , a aos oosson oonn, ,, a aos aooson soon, n,, aoson, aoson, aoson, aoso aoson, aoson, m aoson, aosonn,, a aoson, aoson oson, aoson, aoson, a aoson,, a aooson, aoson, aoson, aoson, n son, aoson, aoossoonn,, a aoossoonn,, a aooson, aoson, aoson, aoson, son, aoson, aoson, o a aoossoonn,, a aoossoonn,, a aoson, aoson, aoson, aoson, oson, aoson, aoson, a aoossoonn,, a aoossoonn,, a aoossoonn, aoson, aoson, aoso , aoson, aoson, a aoossoonnn ,,, a aoossoonn,, a aoossoonn,, a aoosson, aoson, aos on, aoson, r a aoossoo onn n,, , a aoossoonn,, a aoossoonn,, a aoossoonn,, a aooson, or son s, a aoossoonn,, a aoossoon, aoson, aoson, aoson, aoson, aosonn,, a aoossoonn,. aoson, aoson, comrsens s ao smeeu eemnceomens,e sneoman ano or anennnramenereo a aoso asn se,o arosereonn w, a amnoo ac susuons seecerom: aoson, a son, aoson, aoson, a oson, aoson, aoson, aoson, aososonon,, a aoossoonn,, a aoossoonn,, aoson, aoson, aoson, aoson aoson, aoson, aoson , aoson, aoson, aoson, c a aososonon, ,, a a aos oosso oon nn,, a , a ao oos sso oon nn, ,, a a ao oos ssoonn,, aoson, aoson, aoson, aos on, aoson, a aososonon,, a aoossoonn,, a aoosoonn,, aoson, aoson, aoson, a son, aoson, aoson, e a aososonon,, a aos oosson oonn, ,, aoson, aoson, aoson, aoson, aoson, aoson, aoson, a aoossoonn,, a aoossoonn,, a aoossoon, aoson, aoson, aoson, aoson, aosn, aoson, aoson, aos on, aoson, aoson, aoson, aosoonn,, a aooson, aoson, a son, aoson, aoson, aoson, aososonon,, aoson, oson, aoson, aoson, aoson, a oson, a aoossoonn,, a aoossoonn,, a aoossoon, aoson, a os n, aoson, a a aosoosnon,, aoson, aoson, aoson, aoson, aosonon,, a aosoon, aoson, ao son, aoson, aoson, aoson, aossoonn,, a aoson, aoson, aoson, aoson, m aoson,oson, aoson, a aoossoonn,, a aoossoonn,, a aoossoon, aoson, aoson, aoson, aos n, aoson, n a aososonon,, a aoossoonn,, a aosoonn,, aoson, aoson, aoson, a oson, aoson, aoson, o aoson, aososonon, aoson, aoson , aoson, aoson, aoson, aoson,, a aoosson, aoson, aoson, aoson, aos on, aoson, aosonon,, a aososonon,, a aoossoonn,, a aooson, aoson, aoson, aoson, a son, aoson, a aososonon,, a aososonon,, aososonon,, aoson, aoson, aoson, aoson, aoson, aoson, r a aososonon,, a aososonon,, a aoossoonn,, a aoossoonn,, a aoossoonn,, s a a aos ososon onon, ,, a aososonon,, a aoossoonn,, a aoossoonn,, a aoson, aoson oson, a aososonon, ,, a aososonon,, a aoossoonn,, a aoossoonn,, a aoossoonn,, u a aosoon or, aossonon,, a aoossoonn,, a aoossoonn,, a aoossoonn,, a aoossoonn., oman aen ooer o erx aenmeanr enmnomraenmsen o senreoeaoman ano varansncue snen an one o os:-,-, o,vn an amsn:o ac- seuence asene :, :, :, : , :, :, :, :, : , :, :, :, : , :, :, :, :, :, , :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, : :, :, :, :, : , :, :, :, :, :, ,:,:,:,:,:,:,:,:,:, : :, :, :, :, :, :, an ma com:rse,rom oneo:ve am,no acee:on, :, or aons s orrom oneove amno ac exeman. r a enm exoemmeanr, eemeoemonen o,r aeoenes aorne n oorn a-conseocnus avrees. connseecu anove.er enxe amnoarer emeoeemoenn o,r aeeoenson a or aons are ae-ermnus.n aurer exemar emomen, or aons are ouse ore an ae-ermnu sse.unenece a anurer exemar emomen,eeeon exemar emomen,eeeon or aons are ouosre o aaa seuence s.enueenc ae aunroer aa seue r nn axeemn vaarnc ran eem. s suomens onn aenncueor exame an woumaon or exame, asce acscsencnc o arerns veacranc mnan com aernse v oanrea onrs. omans o one or more sneoma more anennn n an exemar emomen,n aennon va arans. varana comrs ens asecc orrseccnn aen comrs es an anennnomana secca nso ana encae,s a anea asmno acen secau,e anceea aseasencaenoca, aeas enca, aeas : e amno ac seuence seorn onnn a.no exem aanr emom aenn, comersseesc anc a omrnros acec sceuenncn aen varans caaeeas enca, aeas enca, aea e aeas enca, a seu senncee seorn : s enca, aeas oe amno ac o a ane amno ac seuence o an anennnoman eomsaenc anc orors oerc o ac snneno ameann v aanrao varan asscoseeren. a avne amno acn s meaue cnocme serseo: avne amno ac seuence seorn :r ann a a, a e amno ac seuenc vn . a e seavonrne :, or avne amno ac s amno ac seuence seorn , a e amno ac seuenc euence seorn : an a avn n anoer exemare em seoormenn,esec:. comrses an anennnomana seccancs oorrs-e acncan comnr aseesn an v aamranno acen sceau,e anceea aseasencaenocae, a amenaos enca, aeas enca, aeas n aurer emomen,esec acc or sresueecncec senorn anen varan m:a c.omrse avn a avne amno ac seuence seorn :, a amne amno ac seuence seorn : an a avne . ao ac saevnuencee s aemnoorn :, or e amno ac seu ac seuence seorn :, a avn seuenc ence seorn : an a avne amno ac omeen senornn a :. aen, or an snne aoenmse a ons n aneoresenscsocseosureere awso e.ncomassosea comee w ann one or more sneoman ano or anennnnraemomenan aenreooaevsna a cnomee w seuence asscoseeren arero amno ac nn an aenn e axsemscarose emeoremn.envee c.omennn aens caae o comen w a nnno amna exnesmaar are e cmaomene comennn aen comrses one or more anen n an ex ae o comen wenn aenscoseeren. ano maeem seeacre emaseo omne ann, a coem oennnn an aen or comen sneoman anen asescreeren. ssas , , ec. usn a anon m anaoeer s eexeecmearas eem oomen, a comennn aen or comen sneoman n some ex n screenn assasescreeren. ano comrseesm ana arm enmo aocm seenuse,e comennn aen or comen sneoman enca, aeas enca, anecaes aeasencae,n acaea,s aeasencaen, acae, aeas enca, aeas encaoe amno ac seuenc as , or s:-, s:-,e seor:n a,n one o:,s:- :, :, :, :, :, :, :,:, :, :, :, :, :,:, :, :, :, :, :, :,:,: :, :, :, :, :, ,: :, :, :, :, :, :, ,:,:, :, :, :, :, :,:, :, :, :, :, :, :,:,: ,:, :, : , : , :, :, :,:, :, :, :, :, n oer exemar em:om,ens :, or :. ano ma comrses amno ac res,uees comennn aen or comen sneoman o s:-, or s:- o,e , , anor o an one :, :, :, s:-, :, :, :, :, :,:,: :, :, :, :, :, ,: :, :, :, :, :, :, ,:, :,:, :, :, :, :, :,:,: :, :, :, :, :, :, ,: :, :, :, :, :, ,:,:, :, :, :, :, :, :,:, :, :, :, :, :,:,: :, :, :, :, :, :, o, :. r ucec acs, vecors,s, ces an meo o mannn aens aen or aenresnen aesnco vsaurre aso reaeso a nucec ac moecue or vecor encon ann nn some emomenasn, ase nsuccoesec eren. ane ac moecue or vecor encoes an ano or an anonn or so amn ner an eamm enoenmnener nse,o o raer a m neu v ncareacn ere aocere or mo ao. vecue or vecor encoes a sneoman n some emomens,e nucec ac moearan ereo. aen. cue or vecor encoes a comen nn or anen some emomens,e nucec ac moecue or vecor encoes a comen ano oman ann n sonmoen e omra r aom nmen eenns,ereo nne n.uracemcen ac moecue or vecor encoes a comen sne moecuen some emomens, e nucec acere moo.ecue or vecor encoes an ano-e n. n s soommee em emoommenens,s,e neu ncuecce acc ac mo mecue or vecor encoes aroen scao. mouan a oecue or vecor encoes anmmune ce srane.uceecen n a. uccec m aocecu mesoe oc eresen scosure ma e sne-srane oroue- ronuceoes, mo e eoxruoensucesocosees ore mreon mea r coomrseseoxronuceoes, moecues o eresen sco nuceoes. e nucec ac n some emomens,sure ma comrseor exame . susanaueoee sanmeer oenr aeunecneer n oau ncce a oc ac eeuve s ane eeu ncen a ccoees, as se soeruenncesaae en.coee same, use.s suc,n s mno ac seuence ma erouce an ac seuence seoormen emaoemen.sn, somee nu ecmec ac seuence ma e a varan o e nucec , aeas , aeas , aeas , aoeasmens,een nuccaeco ace v naurcaenc m aca see aueenacse seomoarn orn aoareons acnos eencoes an amno ac seuence o ann aen, anennn e nuceoe seuenceerse on. eneranownne eresenscosure mae enneere usn meosn arn orero aere nuceoe seuencesor a vare ouroses rcouucn.,u n soumneo, m raonomcaroanm oenae coonn ann,roces resansse,m anor o exeresson oeene snec oonuceoes mae useo enneere nuce neramens an oonuceoe-meae se-rece mu oe seuences.or exame, new resrcon ses, aercosaonaaerennse,s csa mnae coe uosnereoenrernoceu,cero muucaonsa creae an soor.oon-omze nucec acs enconeo e sce varans, encomasse eresenscosure. ee cansescreeren are mecorseoee cans annn aensscoseeren mae mae a vare oransamaroose sene ar,ncun recomnan meos orn vro seuenceseonnenrsarans ere,aeon. noo ane exreess coann vseescreeren are exresserom nucec acranscrona anransaona conro oceonr,ser.ee., c ao venco sreueance conn aanasrcuea eremosensor eemens mancue reuaor seuences, suc as enanc .ese romoers, an' an' un-ransae r ers, consuve annuce useo ex varreses oe exoresesone ve ccaore nso oson r cse. n snse amesnnoewscnroeoeser o sne ar mae nn aens comose osncoee cans, eac o sen.ne even,ae rove searae exresson vecors or a unu ucoee can mae resenscosure, e exresson vecor.n accorance we searae ve ewo cans o ann aen mae encoe a sne vecor or recomnoco anersv roeee nsco s, arr ae se s o. aeen e exxrreesssseonn mammaan ces.oron-ermroucon oncororaenoeos ceenome o ssem mae usen wce semens marers.os cee r mananen an esomaorm e use o seecae seuences ororocesse m eaxresese cosoeneorse aneeos mreouaaseo enx.resseroenn oose censserea ea.ve., sec,c ceeau,ar mac,ner an c, aanracersc m aercansmsoros-ransaona acves mercacnesseuureoeco e avaae commerca anrome anro n an mae coseno ensuree correc mocaon s ern oes oe e exxrreesssseon soseem caen.e use.esencue,or exame, mcrooransms vuecco arssaceaesrarraannssoorrmmee w recomnanaceroae,asm, or cosm exresson acuovrus vecorsan ce w sseemassr eaxnsroesrmsoen w veco vrsran osec ce ssemsnece w anma ce racera exresson vecors or v e srseseemns.scosureereore reaesosoae cesrans oercor, nucec ac, ses o vecors or ses o nucec acs enconoermnen or araennssecaen woe as re asennensconsurneeraremoreen assoe rereao suc as sneoman anoesescreeren.e anoes or anennnrameesnos ssuocae as c sens ceaaomea onr e axnreossneseerenn aens eren. oscose or anenenresnenrasmceonsusre aso reaeso a meo o mannn aense.., anoes rovn a cee.., a mammaeraeno ce suc w as s an veceoorm ora sne asn o voees.e meo ma comrse e.., anoes or anennnram cors enconenn aen eren an ensereo suc as sneoman anoesscose nnrae a mo mew enon s su m ex care as ass ssoon n c.oemrsesurnenn aense.., anoes or anen , on a soemase emo, ameeanss,e, mom aeaon an o moaneusacuerreeo aorwoms coe resac or c aeureresv.e o aeas n some emom eas omers. n some emomeennss,,eeuureveseween.o.. n some emomens,eurreevveess aeween.o.. n some emomens,eureves aeeaass..--.... n snn s soommee e emmoommeennss,,eeuerr oevee anso.es- or a.n.ennnramensereoe.., e aenoomaens o anr anoenronunceram ceenss maereoe. or more.n somensances,eer o somensances,eer rouce ces mae. or more.n ma oe anoes or anennnramensereorouce ces ereoerouc oer more c.ens s moameensances o,r meoree.rn o soe anoes or anennnramens anennnramensereorouce ces mameensance osr, moere.ern o somee annsanocese,s oer er oee an meooe ms oar a ansoe cnomnrsne a sraem oenssoaerneo anrouce ces mae or more. nnramensereorommur orurne anoes or anen onuae es. aeraenu ssocm meo emeo orm wens a,eeecnan aen oeresenscosure mae conuae w ces weno uuncon,ueaen,ne areensesn oe m sceoe ore.senscosure maave acv aansumor nn ae sure aso encomasses a conuaeorm o sucumor cenn s wns. en a uenncosnuescaree.neren ma,n somensances,ave no orow acv aans so asoeve n aens mause conuae w aeraeuc moe e anroeeesr oare aunce moeo -exressn ces. oman anoes or anennnnnnramraenmsenesreoere moa oee conreusenaescosuree.., sne eraeuc moeoreraeucuroses o ,or exame, w a anoscuroses r w aeecae moe.e.,oreecon or n somensances, oerraoe aucro oerne aecowane m ano eexeensea-e ors aaceo nanoarce. resues oe anoes or a maeneo aeas one amno ac n an exemar emonmeenn,nen anramensereo. resenscosures conuae w aeraoeuesc o mr aoneen sucn asnorra exmaemnse aenreo w ooue mmoeacuoen,, a cemoeraeuc, a cone, a cooxc aen, an an-cancerrue.., sma canum-e aran ,eue ecnu me. mo-e, moan1e7-n 7cu,eo,noer- exa,m ane 2 m aann o wersou recomnzaeon,osreu sm-e, anraem arcn,e.r.,noueecaunm,aex.an.,es,useu,smue..,13, coere..,u67,-uorourac, aursan, monome aursan,o mmaonaanss ennoosoxe.n,., r mcenr,a anusrnse,anase.., monome anaouese..,u , camoecn, exaeca ansne,uusnrnoecan orr nervavese..,x,eoecanervaves, n anoneor eexceamn maeaoese..,- an oeroxns. erese r emomen,e anoes or anennnramensereo o maonn, a mscooesureesec coanueae s wecro ascoeecc,aoeo mcoeemcanc,uocnor exame an wou cemca anor oersca means.e emca,mmunocemca,nrecor exame va a ecae moe mae coue eerrec anor oee can ornnn aae, suc as, woumaon, a or naeoe eecae moees m en usn meos wenownne ar. we vare o conuaon, sa a reuere umseen,s w an aeva caoceenesreunmenna onon.e se snusave reure, ease oncues,us nomeo, auorescenae, a ra eecae moe maon,125,n111,c99131oacveaeor exame, wou nucear manec resonan,ce ac anvencaue,n aousmrnoensc eemnnaes,o ao cesemor scanner ec, a cromooreae, an enzmeaeor exa umnescenae, a aaneosaase, e me an woumaonorseraseroxase, anorrouce aeecac.e, suannaumereos a anoworn a noarn ao sarnace.romeeceaeee moe ma cause e cae moeoe aercmeac.eu encomassaermcaac ceoum ecaos re csoo emns nosons comrsnnn aens oeresenscosure are aso n some emomens,sceosuraer.maceuca comoson comrses ann aen varan. anennn somner eammoenmenerse,oe armaceuca comoson comrses an ano or an n some emomens, ore a vaarramnaereo. ano o ceuca comoson comrses a sneoman n sro amne an emeonmnenns,raemeanrmaecreeuoc oar a co vmaraonsoenreo. aen. comrses a comen nn or anenn somnen emraommeens,e armaceuca comoson comrses a comen ano oman ann somoe e omr anomn enense n,reo ne. raarmmeanceuecraeo c.omoson comrses a comen sne moecuen some emomens, e armaceuca comoson comrses an ano-e n. n s soommee em emoommenens,s,eearmaarcmeuacecua ccoam cooson comrses aroen scao. mouan aen or moson comrses anmmune ce armaceuc cae cso emxoresssonns meammeurneeo cree c momourasene a aenn. rammeennssereo o eresen sco oes or anennn ra suree.., sneoman anoes or anen. nn armaceueereo caarm.aceuca comoson o e resen scosure ma aso comrse a aens.n some e amcceoameen csa,rreer. armaceuca comoson comrses conuae nn anenn snomne emraomemens,e armaceuca comoson comrses conuae anoes or nn ramen erenos.enre soom aes emscoosemenerene.., sneoman anoes or anen anoes or anennnramensereoe.s,., senearommaacenu aca comoson comrses ramen ereo conuae w aeraeuc moe.n some emonmoenes,s ore anarmenacenucna c aonmooseso onr c anomernsesn annoraemse onr aneennnramensereoe.., sneoman n aon reo conuae w aeecaeae. armaceuca acceoaee c aacrrveers cnomrersenns, wa aer,arm,ac saeu scoau coonms,oesaonns, o mas, a cconan an oer excens an auxaresaacaerocessn oe acve com oos, rearaonsa mae usearmaceuca.n oernsances, su ounsno serze. crearaons mae e aens usoeeeerern w, "armaarcmeuacecua ccoamo asccon" meanseraeuca eecve amouns o emusers, auvan anor c eaeuens,reservaves, souzers, a amo arrers. "eraeuca eecve amoun" as useeren reerso uc comunos wocns arroeveus as oreraoeucz eee ocr oore arwvseen croenoromnu anao ansm annsrnacuone remen. o varousuer conene..,rs-., aceae,osae, anonc s uens as aumn oreanoreven asorono suraces,ee ren, aves suc uronc,e ac sas.ouzn aense..,rense..,ween™,ween™, oxanse.., ascorc ac, soum measue cero,oeenecero, an- araens,un susanc ,reservavese..,merosa,enz acoo, oomer es oronc moerse..,acose, manno, covaen aacmenncororaosn o suce a msaeoraenoe onre onocoarcouaeerreoaeran,o cnosm oeoxamoenrc w com moeuanso snus, or oacc ac,ococ ac,roes, ec, or onoosomes, mcroemus c as unamear or muamear vesces, erroceoss, or ons, mcees,nuenceesca sae, sou, sa, rae on seroass.uc comosons w onroe or susane ree vvo reease, an rae on vvo cearance. acs, waxes, os ase comosonsncueormuaonnoceose..,a ome .so encomasse escosure arearcuae comosons coae w scosurrseen.c.o,rooraoxeamaerrscu oraeoooxrmamsnerose.cveer co eamnos,meronesas oene comosons oe enancersor varous roues o amnsraon,nc ors orermeaon vana, reca roues.n one unarenera,umonar, nasa, ora, arenera,aracancera,r eamnsmoucmosean,eransaremrmacaeu,canr caommusocsuaorn,sn aramvennosuesre, nnrraauemrmoa, sucuaneous,nraeronea,nravenrcuar,nracrana an arenowur nra ner.,e as ar us aeneren "armaceuca acceae carrer" or "armaceuca carrer" . sane. onanc,u suce,u are nomeo,.-. or. osaeuer or aueous souons, susensons, ana ermmuacseounsc.axam acceesa o neo cna-rareuresou msae aueous or non- co,oeeneco, veeae os suc as ove o, a sovens areroene e oeae.ueous carrersncue nnecae oranc esers suc as susensons,n waer, acoocaueous souons, emusons or so cun sane anuere mea.arenera vecesncue soum core nruavoenn,ous vneerc'sesenxcruosee,uex arnose nu anren so reuemns ceros,r eee,acaener's orxe os. ase onner'sexrose, anee.r croe reensers suc asose suc as,or exame eservaves an oer aves ma asoeresen, or an , anmcroas, anoxans, coan aens,nerases anee. ce cuure comoun,eeraeuca eecveose mae esmaena eern ma aso aess uases oron aneemrma mneoees s cuocnce ans mracoen, ra rasn, rea ans, roouse, o ors.n anma moenormaon maene useoeermne useuoses an amnsraon.uc eseecnues are wenowno on rouesor amnsraonnumans.oa amoun o acven e sene ar an aeraeuca eecveose reers ecac anoxc m reena ameoraese smoms or conon.eraeuc w e aeeermne sanararmaceucaroceuresn ce cuures or eraexermena anmas, suc as cacuan an conrasne50eose ouauonca sa escesc.venn oe oeouaon an50eoseeao oe an suecn nee o armaceuca comosonsescre aove mae aeo orses, ra era,ncun,u nomeo, mammas suc asos, cas, cows, es,ar mmoanceeusc,a an com esoescaonsumans. rouesncun,u nomeo, ora,nersacvreneous,ernernam muascuea ar,mnrna-sarereera,n anram nuemuear onraeca,nravenrcuar,ranserma, sucuaneous,nr r, sunua, or reca means. aeronea,nranasa, enera,oca, anon o arn a enx aenmeanr enmnomraenm,eneearermoaceuca comoson comrses a sneoman , seecerom , , , , , , , , , , , , , , , , , , , , , , , , , , , ,, , , , , , , , , , , , ,, , , , , , , , , , , , ,, , , , , , , , , , , , ,, , , , , , , , , , , , ,, , , , , , , , , , , , ,, , , , , , , , , , , , ,, , , , , , , , , , , , , , , , , , , , , , , ,, , , , or a varansuc asumanze va , , eo o rans orer conuaeormereo. armaceue use cares ceonmosscoosnu croem asros rnea sesoe use onn aensscoseerenor n some emomens,e meoam coemorrreamen osorers orseases. ereo or aarmaceuca comoson ses amnsern ann aen or a varan n some emomens,enn com aernsns a sanm aenoo a su orecn nee. ereo or a varanereo ane meo comrses amnse an anennnramen nnramenereo or varanereo or aarmaceucarne ano or an anen a suec comoson comrsn sameo ramennn so n eme reee o e.m oro a vmareanns,eereon ann aee mnes a sneoman ano or an anennn ano or anennnramenereo or a vo comrses amnserne sneoman comrsn sameo a suecn nee. aranereo or aarmaceuca comoson comrsens s aommen esmeronmeen cso,meennnn ane anens a or comennn aen ane meo sameo a sue aarmaceuca comoson comrsn ramenn soemreec o emn n anoeem. ee mnes,oe comnrnse aens a comen ano or anennn nnramener s amnserne comen ano or anen n some emoeome onr as,aermnacenuc aae cnoms ao csoon comrsn sameo a suecn nee. nnramenereo an men sneoman ano or anen a e meo comrses amnserne comen sneomanon a sou or anennnramenereo or aarmaceuca comoson comrsn same nec sonm nee ee. comrses amnsmeronmeen asn,eo-nne m aoeecnues o arn a anaro-e moecue ane meo sameo a suecn n maceuca comoson comrsn comrsens anm somnes eemee rno.meenros,ene scanon or a aena crommacerusesca a coromeons scoano com anrsne s maemeo a suecn n o meon co sommee re. s eems aommnenss,enn aens anmmune ce mouan aen ane comoson comrsn sameeron a s aunecmmnun neee ce or c meosuan aen or aarmaceuca mouan a moeo exressemmune ce seases.en sonen mene em areoeon.sm oens,eeresennscosure mae useorreamen osorers or anoe u n aen oeresenscosures a sneoman n somsee eomroreamnsorers orseases. an ens,enn aen mae useoareeraeucs anor nnos acseno a oaree creese,n crcuscaonroen orssue.ccorn,n some emomens,e anoranoscso aare ce, csrcuureasn a srnoeen oormassnue a.no useoareeraeucs useorn seormaeeu emc moemoenss.,cecornnn, ane snom mea emeo conuae w aeraeuc moe an scosures a sneoman a mens,enn aen oeresen n some emomens,neon usne aoereraeuc meos. usereosreeecon ora n mae conuae w aeecae moe an e nosc meos.ccorn,n some emomens,enn aen o nn somsec eomsuroesm ae snns,eeomnann an aenoe. us.,e anoreecon oranosc meos. suc as,ror exame, sne o or anennnramenereo scosu oman ano or anennnramenereo oeresen ne s moamee em useomorenarenumorsn vvo. ereo suc a s,enn aene.., ano or anennnramen useorromso,nor euxmamor ree, srenssoeno amnaonr a rneucon or anennnramenereo mae enn aen oeresenscosureeumor voumen vvo. ereo suc as,or exame .., ano or anennnramen use use , sneoman ano or anennnramenereo ma aene..e, mo aner coanc o oerre or aeam nree esnen.scosure ma comrse a se o amnsernenn ano nnnramenereo suc as,or exame, sneoman nn a oern ano aennnnvnramenereo or aarmaceuca comoson comrsne n some emomeunan nee. ereo suc as,or exames,, sneenomnan a aennoe.., or an anoen orn annenramnennerramen amnsere n accoranceon wr caonmcee wnao eos n acc n resene wrsecs ae c onem sureso ,coe esrua nree,u vec.nvuan nee mae auman.urer n some emomen,reamen os uan nee mae an anma. exresson o arearcuar conemoraeers. orn sosemaese esmao amree cna,usre or assocae w orseasesa are cause or assoc eamen osorers conemae. ae w overexresson o are asoarcuar nn s soommee e emmoommeennss,,eesnorner a orense oase meareseen cancsecr. a sn woumaons, an ano or anennnrameneorseuore sunccu as,noro erxa emxame,e a mnusceuaorma, onr anuoson o.r anennnramenereos amnserenravenous,nra- oman ann somoe e omr aonmenen,nen anraomeens orer anennnramensereoe.., sne man an some emomen, eos amnserenravenous. o e anoes or anennnramensereoe.., sne nn somoe e omr aonmenen,nen anraomeens orer aenos amnserenra-muscuar. oman ano or an ennnramensereoe.., sne n some ennnramenereos amnsere nuson. an ano or an emeonmnenns,raemnenne areoen sucnc aus,noor exame an woumaons, anennnramene r exame, a sneoman ano or m reos amnsere a aose o aroxmaeeween.o m,,..oo m m,,..oo mm,,..oom m,.o m,.oo m ,.om,.om, or. an anon so. omre an emeonmnenns,raemnenne areoen sucnc aus,nor exoarm exaem, a sen ane woumaons, anennnramenereos amnsere oman ano or m. a aose o aroxmaeeween.o an anon so omre an emeonmnenns,raemnenne areoen sucnc aus,nor exoarm exame an woumaons, anennnramenereos a e, a sneoman ano or m. mnsere a aose o aroxmaeeween.o anon o or aenr emenonmenns,raemennner aeoen sucnc aus,noor exame an woumaons, an anennnramene r exame, a sneoman ano or m. reos amnsere a aose o aroxmaeeween.o an anone or o aner eemnonmnensr,ameennnere aoe snucn acs,uorn eor exame an woumaons, anennnramenereos am xame, a sneoman ano or m. nsere a aose o aroxmaeeween.o an anone or o aner eemnonmnensr,ameennnere aoe snucn acs,uorn exaomr exeam, a sen ane woumaons, anennnramenereos amnsere a aos oman ano or m. e o aroxmaeeween.o aroxmcaceorn. m,n. exne omearr exe emmoamens,eose oenn aen mae aroxmae. m.ne o r emomens,eose oenn aen mae e aroxma er exemar emomens,eose oenn aen ma e e. m.n oer exemar emomens,eose oenn aen ma e a arrooxxmmaaee.. m m..nn oee or exeerm exeamr eamro emmoenms,enes,osee oenn aen ma mae aroxmae m.nurer exemar emo ose oenn aen mae aroxmae m.neurer exe mens,eose oenn aen aen mae aroxmae m.n a mar emomens,eose oenn nn aen mae aroxm ona exemar emomens,eose oe nn aen mae ae m.n oer exemar emomens,eose oe enn aroxmae m.ne oer exemar emomens,eose o enn a aeenn m maaee a arrooxxmmaaee m m..nneuruerr eexre emxemara erm emoomens,eose o oenn aen mae aroxmae m.n aona exe mens,eose ose oenn aen mae aroxmae m.n oemar emomens,e ose oenn aen mae aroxmae r exemar emomens,e eose oenn aen mae m m.ne oer exemar emomens, aroxmcaceorn. m,n e.xenm oaerr e exmo emore armea enn ms, m oemeose. oe sneoman ano mae mae aroxmae. m.ne oe ns,eose oe sneoman ano oman ano mae ar r exemar emomens,eose oe sne sneoman ano maoex amareoxm.ae m.. mn oe.rn ex oemera erxe emmaorm emenos,meenoss,e oe emoseo omenes s,neeoosem oan aen snoe moamane a anrooxm maaee. a mroxm.aene m oer. exemar exemar emomens,eose oe sneoman ano ma nurer neurer exemar emomens,eose oe sn e aroxmae m. aroxmae m.n aona exemar emomeneoman ano mae ano mae aroxmae m.n oer exem s,eose oe sneoman oman ano mae aroxmae m. ar emomens,eose o sne oe sneoman ano mae ne oer exemar emomens,eose eose oe sne aroxmae m.nurer exemar emomens, emomens oman ano mae aroxmae m.neurer exemar exemar em,oemoseen os,ee sonsee oomea snn aneooma mna ane aoro mxamaee ar moxma.en a mona n oer exemar emomens,eose oe sneoman ano ma . m.ne oer exemar emomens,eose oe sne e aroxmae morea oman ano mae wounn m accao mronasn,c. aen w anoeresenscosure,enn aenncunor exame an oman ano or anenn orn anraenmennnereroam meaneer aeom suncse arse,o orn ecxeam wee, a sne oenan once a weee..,wce a wee, once ev e, more ever mon, o erwo wees, once everree wees, once wounm accaorr o onan snc ,ce ae e n wverw anoeo m oreosnens.scosure,enn aenncunor exame an oman ano or anennnr anraemnennenreora mmaene aeremon ssucere as, onocre e wxaemee, a sne n accorance weresenscosure,enn aenncuno. woumaons, an ano or anennnramenere r exame an oman ano or anennnram o suc as,or exame, a sne a weee..,w enereo mae amnsere more oenan once an wosuonm acce aco a or w nae sne ,c ae. n w anoe orres aennensconsurne,enn aenncunor exame sneoman ano or an ramenereo suc as,or exame, a wees. ennnramenereo mae amnsere once everwo wounm accaoronasn,c aen w anoe orres aennensconsurne,raemennne areenncunor exame an oman ano or anennnram o suc as,or exame, a sne wees. enereo mae amnsere once everree wounm accaoronasn,c aen w anoe orres aennensconsurne,raemennne areoen sucnc aus,nor exame an oman ano or anennnramenereo m or exame, a sne enn aen oeresenscosae amnsere once ever mon. anxreosseos wc are a urearcuar encomasses sneoman e mnsereo a suecavn asorer orsease assocae w nn s oorm we emome onvse,rexeresson. amnsereo a suec an- sneoman anoesscoseerens ceun cancer, non smaav cne caunncer ca sneceecre, mroemom eea cancer,un cancersuc as smare neavereas cancer, reca cancer,ancreaac, craonsceare, canocear,sreas cancersuc as cooreca cancer,asrc cancer, ovaran cancer,ro cancer, somaco cmanac,e cervca cancer, urnaraer, cancer oe uerus, esoa r, cancer oe n oer em ea cancer,ea an nec cancer,oo cancer. amnse omens,e an- sneoman anoesscoseerens nre ano ex ae smuaerc eamvno am measac cancer. ano or an anennnraenm,ene mereeoo or c aomarrsmeasce aumcans ceormnos a sonn coemormsan same. n o aronx smoamee emeowemenen.s,oe mnn a onecne as w ae sen.en ooman ano ans use a aoses a conuae sneoman ano ans er emomens,enn aen m once use a aose o aroxmaeeween.o scosuree a wneen. aene.., anoes or anennnramensereo oeresen e mecaone o use aoarrecuecaronuroses. conann or susece o conannaree marae weereormnenn a venroe.., c aonnacones a or s aanmeen, nenanveranmnen ussnere aoeeescreeren anuann a sna assocae wosve or same oe same ma orcnaone aromara au ms.ammae.., auman.e same mae assue n saonmee ermomoem menams,mae o sra am cee c muauree su ae sernruaman. same, semen o same, aasma same, aoo eeconr o asc acaruc oanerome mamma. or anennnramenusarearreoe moa anenevrourame an vvo amnserne anoes osve or neaven nuann a sna assocae w oneecnne uressnenc aeecon aaraus. ano, sma moecue, anoees o or anearenennne saramme ornenvua, arue.., e amnsereoen ensereoscoseeren ma omanonanoscvua. comanoneresen acaon asoroves aes an mecaevcea mae use as a ereseeeasn moasc.e useo evauaee exresson o numor orumor ces anor nnc seom oe m emacroomaesn aumor. aren .ccorenns,,eeeess m maaee c caarrrree o ouurororean a suec w aru e eeorreame oeermne weer a suec wou ruarne oner emon .m wecncosr,e nereus. , meaese m caarree c oaurreur onu oor sueesermuneen woereaemen w a resonoreamen or no anoro mo re suec n some emomens,eesnor ononreamen. ane oruaren suc m asaor eex uasmee as an a c womoanuonmaanoscoreamen w oocsncunenn aen on, sma moecues an . sscoseeren or aneraeuc anoes aans ooen.. s.o,mne v emvoo or emxe vnv,o.eese ceomrses ann aenoreecn numors or macroa s ma aso comrse ann aenoreecnumoreve o seees ece.se maomear caerrr eex orues,soonr e mxaam asese,s osne a.unm aonr emoos omeann,e erom aaen ane eermne an mae score asow, m xresson o s aen.n anoer emomen, oerae or sann we nn score asow, moerae or euma sna mnancr.oae ceanracrearzoan,seermne an mae macroaenraon maeeer on o exresson or ase oneure mnne,or exame, araneaoos. aocoss, aan macroae marer mcaane useaoo evauae ane macro maacreonareseao aneoena ecacrecon.n an exemar aonevenumors ma emomen,eresence o macroaes enen asse asseen w orearmanac marer . amns euca comoson oeresenscosure mae eexreoaens carrnumors w exresson,ow eresrsesoenn,owscosuow exresson. seccanso arne aerenorne r aeeanesao anso aa m caocmrorsaee a marnern. aena an anen a maen moraeanrcsuoar a caonm mrascero aanen ma areenr.xae seccanso macroaes marersncue mar emomens oan creenn as or exame an woumaons, , , an c. caneens nna aenersoramvnn s oanmee or o mr smarroeres as an oe sneoman anoes or exame, can ore oe assasescreeren. ec.o aenn aens mae sumeonn assase.., , oe sneromeann annooesse oaenreseones scamoseu orer. overan reon o as an one secc amenon acn r aesssaue msa o measure orosossve onnnno w aen s aec sc reon o oro eee or wen secc amno ac resues ecc reon o s enn assas mae carre ou o o are muae oreee. eoees. n recomnanoees or on ces exressn aen wn so ameo emeomee cnoms, arsnnn a s aeeunen mcea aeeasenee conacn a canaenneas enca, aeas enca, ae nca, aeas enca, a amerneoo a.c seuence, or aramenereo or was a ce eexnrceass onr seunccaooeeuem oarnramen eneueo conearcn ae cvane oaeenn,n a anenn w ae anoaense coomuman mae amno ac seuence or aramene rsn a cnomous ramenereo reo or w a ce exressn sucoee or comrsnn an a e sexe. umencaer co enmssonm oen a,mneo c aanaenn aens conace w aoee or aramenereo or w a ce ecxr reesssnues suc-o oeumane orram oern o cenreoom.ous comrsnn an a e sexeumencaer co enmssonm oen a,mneo c aacnaenn aens conace w aoee or aramenere resues- ouman or o cnomous n o or w a ce exressn sucoee orramenereo. comrsn an a e sexeumencaer co enmssonm oen a,mneo c aacn raenn aens conace w aoee or aramenereo esues- ouman or o cnomous er or w a ce exressn sucoee orramenereo. comrses a coenseancnsc ao csaunreaeereonren re aaeesn wo a m aeoo oenn ann aena ac seuence conssn o amno ee comrsn a amno , aoee comr ac resues- ouman or o cnomous seuence o or aramen osn or a seueernecoe a aneas seecnen acanon aeena amnnsoo ace onne aeen. we me ceo ex oreseresenscosure ma asoe carre ou conacn a canae enn aen mas ans sucoee orramenereo. a comr oe seeceor noen caae onno aoee or aramesnes aeruemoan ororav anmno ac seuence conssn o amno ac resues- uman oee a reucenno saoee comareoeu moreoore examese c,omersn. nn a aumena mae seeceor noen caae onno one or ace n amno ac seuence carrnromo amno a reuceeonnsnneo am sano aoc seeueen ccoemearne resues- ouman ororavn eeon. eo auman oeeavn no suc moreoore examese s,eeceenronm aoen meaese c soemecresnor noen caae onno one or carrneeon o amn auman amno ac seuence reucenno saoo ace rese cuoemsare-,o a-um,an-,-o ore-e oravonr naovn a eeon. suc oeoere comarrcusanr,e aemnnn aen mae seeceor noen caae onno a nn aens ma asoo aec s seuence seorn :. nn eecease oner a o comee w one or more asoe aeenns oer anaseen onnenr aomansscoseeren.orearcuar,nn aens ma resens o comee w an one oe sne anoes oe acuzunm sc aomos ,eur eem.o-,mens,,enn aen or anennnomanoes no comee w comeoorn e axssaamee,weeen m ae an canoo a or enenre.s ae.n. en asncosueren man a coemnr ose an a oneer oormn a o:e-e or comrsn a: se-uenceor aneasnoeunmacnaoum,an cnomo,vus ao,e ae c oomrosvn ae sreeoue annce a seeaescn a cencao cnomous or v aramen o an one n an exemar emomeno,mee cnomnn aen. comrsn a seuen eon assaserorme w aoee cnomo ce conssn o amno ac resues- ouman or o nu asn exem oarr a ermamenereo. comrsn a seuence conssonm oe anm,noe ac com reseueosn as-saserorme w aoee o ouman or o cnomous comrsnr n a a anr s ea exem umen encearer con ee smo. sonm oe anm,ne comeon assaserorme w aoee or aram o ac resues- ouman or o cnomous comrsnn a an s eexeumen encearer c eemo.omen,e comeon assaserorme w aoee or aramenoenresosn o amno ac resues- ouman or o cnomous exermenn asn an exeomrnare c eom. moemoenn a,ssaes auma anmno ac am senoue ancce se useunenn n an exemar emomen,e amno ac se ence. exermens anorne comeo uence usenenn n an exemar emomen,n asesas a crnaommoenu ussene amnnon ac ex seeruence.ne comeon assas aramen o aea mens anor n an exemar emomen,e s amno ac resues. ne comeon assas aramen oeweernameno use amnnoe acn rnes euxeermens anor exame aramen oeweeno amno a s,ncunor ac resu c resues, aramen oeweeno amno n aens e,m aroammeenn, oeewumeeanno a ammnnoo a acc s reesueunecse e usc. anorne comeon assa ma enenn exermens . ncueor exame, amno ac resues- ouman exermenn asn aoneorr emnoe cmomen,eeouman amno ac seuence usenenn ouman n assa mancueor exame, amno ac resues- exermennse an ano. orenr eme coommeen,one assuama mnancue amonro ex aacm seeuence usenenn ouman , amno ac resues- anenne cnan. raameennnere ao,en o m ana an comor-seee m aoneennnoman o an ano or or o anmmun cue, o auson wroen scaos ernaev cee, moeu caanna aen oree. n enn aen mae seecerom an ano or anen ce mnouraamnen aereo, an ano-e moecue, auson wroen scaos or anmmune avn an an c exaemen n vaa. rra eme reomen,e canaenn aen ma comrse an ano o sa a on an aeav can varae reon or an anennnoman on annn aonoo oe. rr a enx aenmeanr enmnomoemna,n oe c saanaeaevn cann aen ma comrse aeav can n some emomens,enn aens se on ano. n some emomens,e eceors anoruman . n some emomens,ennnn ae anens sese sceeeceorsor aanvno ar cnomous . as smarw- varaonoa oe s n anoruman scosur neoman anoes oeresen asne en o. cear e omr suoemroernos,ae on snn aeeons seeceoravn an anoruman n some emomens,enn aemnans a sneecoeeso oraevnres aenssoscosure. smarw- varaonoa o sneo caon raeas uman . man anoes oeresenscosureor encan o sromowee ermooam oen ssn,eeomnann a anenoses se oeceereosreavn assocaon raeas n accorance weresenscosu nscosureoruman . uman roen or on re,e an mae measure on recomnan onuen ces exressnuman roen.e an mae measure xemare assnum anan sn aceunes cnanro er ae nson.e sumeon vro orn vvo assaso assessuncon.non exermens anoazaon, , , ce va,n vroumorrow n some emomensr,ne vvonunmo arernows seneceoonr enx verrmoenosen acs aesacrnseeren. n some emomens,enn aens seeceorn vvooenc aansuummoorr c ceess.. xamen-enommaanm anmuonzeas woner aenenmerameunemrar consrucon acos oramasama munzn anmas suc as aacascuna enconeuman anensam anao orr cerasns oveenrecx mreosussne weuummanan an anenesns, c asm e exraceuaroman ouman roena .n somensances : noooca,a.o. - :ean-an ccocm.ros.nsae.., ces overe r sx ooemreess _ . c or n nnsa snacmese, wasa ucsaes asc aunnaen.acos receve c encone w nn wncun sames, so~umons a wn oeumanmmunzao ereneceroneranermao ar monueu s.eso ar wron arnoeancs anmosr n ceears, ae mrxan onemroe nno anesoerowe eecrooraon.ormmunzaon wasnece sucuaneous a u auvan or ceseru auvan ms.ro e en o neccrana or cauaoe scauaone anac e sar oroenmecmuonn,zaeo cne,s w mere o wasree-mnmuneoo roem wovaesaee mne, wum an .eore serum same an sore a -°.ac anma c wasrocesseo easmmunzaon, a receve -weenecons.veas aer moces s.oue anm ma os woeroe w aassoa oeneraeer anmoa remoroveerreaanranon omer noereas owensenreearma oeae snaecusonea snesoar an, ooverveemw oeramumreu,n ezca.on scemessusraeeow. emmunzaonero.e anmas remaneea urn wea ws mooenororeceuare.rouou a mmunzaon ssue coecon saannn o reconsuemmunerares aanse anreonms conecn aerae re, sne-oman ano aesara . anm reseneraerommmunze aeass w weerreerasnn seeec aean wser aene roeunn os onearnensnor on a reocaom onoanur rouns: anen-nn one roun w a cene exressne anen oner umanroen,oowe nvua cones were ranomsoaeromeaeese..,- or oers. annn, an seuence oe ano var s recovereromena roun o ramens encon s oraes oormaumnsa oane aner seuencn.no consrucs comrsn a nze versons wereenera sucone exresson ann v consan reon o auman anoe..,uman cor ,anee,omaarno e a ann oron v aevso ceoemsn arres. ona vanrea aen reesoens a ass seescrorenerean.e oae xam se-sr woeruec exonre assneurcaon o ss. exermen n ces ansoae asroenmers.e ssenene ness, seac sceacon me annoonre oureersw asse eac oo o are comavoesee o corwroeav cans. canor varae reon amno ac seuence s esonneav ae or eornnae oae,ae, romeroena cmeers.e..,omomers were exressen. m or m cuure voume or onsruc usnex ™xressonsemermoser,a. no. resexawe™xxres-sso cness wemere aeorwmeoos reerc,ovaer. non. cuureo.rwo o6r more ceasssames aeo wrecransmeceone. weerse wereueenoassxae5- exver5-as une reacx-x6ceesumm anre-w onarmeeao or°a.earororansecon c,e cessm werne6xueo™ xx6-resxson6m o cuure nsecon, ces wereurerueo.x cesm. o voume m voourme w masue w co ™ meum or. m o cuure o cucure vo o cuure voume.xecamne™ eaen or. m ann ume or m o cuure voume was aeo meum conann cuomaeex w wasxranseceraremneo™ cuure caomxexe6s c ae rsoommem weraureor- mn.enencuae a°uner an um w san e swrn s.aee ces were - aer onse oranseco2n,x ™ee. mor. m o c r, rm. or m o cuure voume anx ™ enancer o uure voume m . mor m o cuure voume were aeo r. m o cuure voume ncuaor se a°uner an e ces.e ces were reurneo asos-ransecon, suernaa2um w san a rm mm or. uernaans wer ns were care cenruaon a xor mn. m eer-serze usn aaene™a-ow™eresos°aeernsaer anaer un ermocenc,a. no.- an were sore a orrozenor eorerarnes sss. econaw.eesx weree cneass wsaeree a evoewre-o reacosv uenrn cueu rreeacorwxo o6-r mxore6ceasssames a wa wrmecome°.e weeraeruoerooraxnse5c-xon,5ce cess wmerenuxeo.TMx6resso6neumre- oransecon, ces wereurerueox6vae x-x an onea voume wasue w - ™euceerum c meesu mm. o m o cuure or. m o cuure voume an mor m o cuuroe ana voume o eaen or. m o cuure voume. mor e voume.xecamne™ meum- ™euceerum meum or m o cuure voume was aeo or m o cuure voumeoncuae a ro . m o cuure voume. m xecamne™ was aeoue a omemeraureor mnues.ue xecamne™ so nncuaeor mnues a ro6omemeraure. swrn. uon wasrans°erreo cuurero roax cesm we san e ces we sreanecr,uae r a uner2an um w overn ranseconn m.- aer onse oransecon,xecamne™ voume an ancer or. m o cuure voume. mor m o cuure morx m oec caumunree™ voumera wnesreec aonenoanece cres.e ceors w.er me re our cuure voume ncuaso-rr saens aeco°n, u snueerrnaans w a neo aso2nere caruem c wenr suaanon a a rm xmm or. uernaans wereer-serze usn aaene™a-ow or mn. mer un ermocenc,a. no.- an™ weeresos°aeernsaer ana re sore a orrozenor wros raes. vns ar ceouumrnse o usn-maeecue resn eacare,a.o.-- scaawa, eennr on-me sueaeecue resn w eacare, oneour an eur rnaan voume.esn wasncuae w.aor rornecon.uernaaea wrs-aseuer. mrs-, ma,. esn c n was ae onrav coumns ore a mmn on-m coumn. o moummnn. warso weans weas w eue wcoumn o vo.ume wrs-aseuer . aow rae en crae ac a mmn.racons ooeeo weer.roooeneroramcoens v wsuerae n oeuurua oze we cromaorsra-masoraonce a nm were eoreranserrnno osae-uere sane uer acevee ~- . moassumosae monoasc moumreorareero mmoum oossoraaeeasc,.ermoser,a. no. or m sne ucrose. coouemnnsu oer excan.e was carre ou same concenraorsorroensureromrav r r eer ass oresan coumnorroensurerom . asurceromearavcar ceo,uam.n nso w.ere concenrae c w same concenraorvan, en,ue w o aceve-o an reeenruaon a,-, x a° was carre oun o ove ae un same reace-o.assunermoser,a. no. r.nn ae o°e ursnan,esaa monec cuoaurm wne was cnuc-uoaea wss sa.mae was ovoearnen aone eurerae wesan cou.mnoume oeac mare, oa ne.urazeroen a. mmnen,roen was eue w o .oan an eu no.-- reeae un no neurazeroen same on ses were ene wroenrome vsua ouur oom eeu coronm oao aranma cosourmnan rceem aane.racons ooeo nm were nsamee mer. waser uner-sererzmeo uscnen aaene™a-ow™eresosaeer uane c ocaens a c,a. no.- .naroen same was eaen nanomeer aneseor enooxneve wnosae easrr uneers reuacrens orve nrona-re. nuoc.n con.onaroen same was anaze on- on. nssee secon anesern xame moesne- m ann c- vuvmoo arn e-eucm oor ee secs oeresenscosure wasesen esaseumor onsan, me. .ce-- woxeesa ose,ema mec weere- wureceasse o,roemmaear weesrveraoraores. aresveraoraores.onsan eurcase eerrom aaoen-ree envronmen ae anm,aa ocrromn .oroen aon,ma. worce w waesre coonusen accornoeuenes oeanaanounc onnmaa uce rooco arove enmaareommee a . re anenmase umor cerse.n,mas w merece ra onromze mnceo e wxereermmenaanero suuscuaneous w or mon mm3an wereenreaearr wenumor voumes reace or w neave conro.ows weuman uson consruc oe - no ecac waumor voume was measurewceer wee. -,x-,.numosrse osren-- ornum mceearn --, -reae wesn arces a m, onc ors.nure,e mce were mce werereae wesn a eer weeoroses.nureso,e c mce werereae wesrnce asr aces m a.,, o,nc,eer m wee onocreeors wese.enoruroeses.,ee moncreo we arremr weaeree wreae w aesn m arc wes ae mrenosnnruereuenc.ens,ncuuren,e er wee, everwo wees, an everree wees.nu wce wesn arces a. m onceer weeo re,e mce werereae enrae w or wou mon aneroses.nure,e mce were weeoroses.nure, mce werenrreae w a m,wceer er weeoroses.nure, m eae wesn arces a m once er weeoroses ce werereae wesn arces a m once sncano s smnsa o. erouxmcors c womerea oreseroveerou-reoaue anem suases. s-reae mcea enn o an- sso severa cancer cenesurnecsu-. re neavereas cancer, -- re neavereas can n -- cancer, an meanoma ces were cer,x anc5reac werencuae w anc rece anaze ow comer ure.× cesemeraure.n- anorocn ano uonor mnues a room anncuae w cesoroes wereuen sannuero n an ae uer, -conuae secona mrn auneso onesc ree.conerz wnasenumraenecm reeso wnoeen sa wnen mxe w ces.er sannor mnues, ces were waser re resusensonno o-mno-cnomcn- so eemes,oowe were anaze ano™ow comeer oscencuon uon.es owo vaan on sne ces anve ces. e.aa were anaze w oeses canucesrra ceennes.uree, aesee aense- an- ano aneoes exe smarnn x ces,nermeaenno -- ce s soweeesnno ces.one oe anoesounoo s, an weanno -- enn secc oes w exresson cenes ,usran comaraenno e- an-oeso .enn o ss sowe anose , - , anx as .. xame-eorsueo-rnes eo ans.e,, sce.ue, remen anarmaco ces,.vn.euraee aonrerea, amenenae m,c ree wereumanze wnecusman s mon ures an,e mc resene ersmeonneras.n mon c e were noumanze wuman s.uman ces orre,e.smuomuosre ce wesr weernece.v. were receveromemaareororaon a moes,umor voumes were meeamsurean uesnn verne mrcen a smarasono mce.n orwomes wee.umor voume was cacuae usn caeeorsrm anuae mce were we2e one susraenure,en vvooseresons :en × . o ss .m,m, m anme surncaesa weereamen emreaanen mce mon ces s.c. evenserow o -- wer .o sns ooxc were oserve wen anmas szeaee wnerven uamveorra meoemnm3oenr w woses a.n- era causeumor reressonnumors o verare menceo.se wu am, once wee ne -- oenumor reres re. amnsere once everreseo wne weass ansoe acev-e ev-en wumenor a mno-e s was om ur ,n mce, a aose mcreeaummeone r m w. oe asoe oroum a aose o.m ..n --maneumor acv o an orn rereessreo-ncncaure.-e-aa mnocea.e auc sro an s aronn- a mcacvro maaee exane eernn an anoen acv meae m oes sr.eenevreo.uso oo sam mesce w wereere co amnsere a sneose o a, or reare.eve ece aerenmeons an serum was were cacuae o usnen sernumo wnasn m seoasuwreare.e anearmaconecarameers arameers sowaea-e an- n vvoarmaconec ose o- m . o s aroxmae ours wen amnsere a a a nae asnuosraev un.nure m,cee su oree.resenscosureossess an-umor acv as xamee mecansm ma o a acsoonn oucee ss. oeresenscosure wasurernvesae. e-e va was anaze va usn oerom-ea-e ceres-ooowumnnescenas asrseaamenu wres-. ss -- ces were seeen-weaes a x3ceser ure. a°, .es werereae w sso we anncuae overn ce va w2as assesse us ras.oownreamen ma nere-oumnescen assaromea accorno wnu vaarcaureer’ rsenosnru sceocnsc.eave conro wes werereae wsoe conro s s uroses.onro wes conaonrn ces. wc. no. receve a annroeam was useor comarson normazaon an cacuaon en were useor snaumn oercenae ce va oownreamen.acroun meanesce.nc.e o wasreee reermne usn wes conann meum wou ces.aues reresene aeras oreamen wcaesor eac srea.mmena.es wuerree ca suows cesmae ax resouon sem. re usn oreman ,s sown annures-rec,ene ss o-e-rese cnes vcaosure mor, , comareo .. anowcnurn norec aec ce vean e neave conros w varae reon seccor . a an xame assa e- romea, a accvv o.n sres, waesaurree cre csaracer-ze- usneromea reorer r an resusene ae conce ces were coece an usn we anncua nraon o monm., ces were seeeno eac woa waneareasen o an cvoenr recn seunsra. enone e o nexa noem,es as.n sae anoe meu es weceroer ceuse wenreoaew aessae mneunm a,are ces use was:.u m.e raoeween eecor ces anncuae aoncuaorosr,o eures.cor ceousrs weareerr,ansaeersre weor eac we.aes wereemeraure.eo-oucerase assa e euraeo room roomemera susrae was aeo eac we.ncuaeeae a reaer.aa wuerree aonra-ze mn suens.auom cneascnenec ue sna was measure ecraaxxae s sownnure,eese an-on un sreae conro wes. aans -- ces.s reorer assa asos snowcaee caa an, an- or an ano-esene sraes w are ca sa , , um ea seeu oencensurcomn cones com-araeoe an mce weremane w an . s.c..n eer -- or -- ces vou- s3or amnsraon wasnae wene averaeumor sranmse w reaceerenm eme.cosrunucsroane comnoneunres., ssn vvo acvs smarn mouse xame conuaee- wnneernrana romzaza eoanon assa wmasnev reenowo ses.rs,e an- ss were conuaon.econ,enernazaon assaac wveas caerrerom oue aan, anaze usn oonw- ceao ano or amne-reacveeaen, an- ss were conu mer. eas. an- ss were mxe wroeneas annc aeoeroen roomemeraure.e anoea mx was uaeor mnues a resusenene amneo con en wase w e wasnuer an eues conann anoeau maxo wnu aer. meoar exc aemssn oe-reaec avnenecu waase a ae ronomo emscaerraeu.reeoars we mren wuaess.eu aneos wererewoacene manec san an suernaan was euonuer.ue ano w mes w wasnuereore euonnoe enernaz as resusenenoe neurazaonuerrome. e aon assa waserorme w -- cesn aow-aseorma. , w-as- ces were coece anueo, cesm. o ce souon e nexa,ran csoenrrueaoe aeno-wees wearees.ueeso werencmua ceoncnenrencuaor overn. conuae anoes weresruenoe correson aon. oe meonsours an ours.aes w n wes anncuaeoencae serum an ces were re ere wasex wowuer conann aes were anaz susenen oowuer conann- a: uon. neave ane ano.nonernaze ces wereaease on- .s. susorwaeennosv ernaue zrae ces. on a anoursu areern,cueaoons.vee cnonerro an- ano ss waseece aoursor , , an .ncrenaaszaon o an- oserve a oursor , , an . soweeenernazaon was amone an- ss.neresn, was noner esnernazaon smar eoe naze aou oun a susoraee oner an- ss. ne ure, wc reresense resusrom aose-resonse srnsazaon- exermen.nn--n- ran cees,s waas a o usnervueeosae- ereasco onseen aenrna- roe.ome ssnernaze ono a ver sma exene.. zaonnernazaoneves comaraeo , , wereas oers sowe e.., .nernazaon was asase osse monoc coonnau aanono oe ssnosw wno anern-asenzes evcen an monore ow comerm.nm aerours.snerna eroe aso vsuaze mcrosco asusrae u zaonrocess was α ss annernazaon was m re. -- ces weorereae w ours conoca m onore aoursaer mnues a ,ours or counersaneor nucecrosco.s.oees ne weareve s caonnero w an-um saonwe nocn annoo ce ans. reeenre sasa annn-s oser svea sraronns resrceo memrane a, an a an oursuncae ano oers aes r aensu ansnocarew u caeaes s revesa on aenroesennesrncaoszuareo mn.ae use as a nae xame-ecc, e onuae. enn o an-oe c saracseroz caon anomannn enn se es was assesse ow comer.oeermnera cc o an- ss,e an arena ces wereransen anns seacnee w w aunm-an anooese.camne.o5urs aerransecon, ces were coece ocn ano uonorn mnruee,s× a roo cmesem wereeranucrue.aen- w an acn recoeoesr w onerece.ueern wasn sanrneeumeerso w n an s aanen anunceur,ae w cesor mnues anoes reconzneumanc -conuae seconar mnue reonoeen were mxe w ces.er sannor cnomcs,n ces w-ere wa ssoeuonreemes,uooonw.ees r weesursensonno o-mno- ow comeer oscence.aa were e anaze ano™ ve ces. anaze wowo vaan on sne ces an aresnaus cerase, wncusr sesmar-o, ae n aena-ve conr aon.oeres norannseonre an a an- ss sowe seccnnoe - an - caensecon, oserveor comaraor anoes, .., - s as aso . , , seearo e a. nonso aosusraenure,nn o an- sss secc, ase e e reae an -roens, . croaes e weroe ceo caeara wcerzaumoann w raesco amssesse comevoe ure anure. wereoce wocnu nan a overn.er wasn,aes euon er ,orour a roomemeraure.eanwe, uonseeonr ann o-nea s.ors s wass wreares wa,eo ancnou waesr muaenowo.eren. oru sons,s w.ouera,a a,n euoae vso wumeree o seraes-aueer soms an ser.a o. ss were mxe,o maeena concen ue non-aeae ssrom . o.ra.one ors-ae ss . an non- conens were aenoe wes aneaes weren wcuasaenowroomuerss, a reoo mmxee ano e-conuae an-xs wasueo: an a meraure. mes.n unoun conuae eoe wes aer wasnreeemeraure, ane coormer wcas rea rcemoonve wase wraosn aerourncuaon a room uersna coumnonan rme ane same voume o ouon aneece on cer anuerna coaeeroxencuen eac ecraaxxcroaeeaer.osve an neave conros were an su csomraeae. een wu eraecs o-er, aonr-nn sousma , , , , suesneno ver smar eoe n recomnanroen, n- s nos comnene w o o arno overan eoes. uman recomnanroen, asusra n ..ornno eren e enure,mna ns n-oesrom ss an ... recomnanroenu an no comeeornnouman an o nor ceome,em wna ns aeren eoerom . n oreroece - nese exermensaa no sown. w varous consrruecsomncaun snecec ex oraceuar somas,mmunoos wereerorme oorom n o ane csene eaconm onanroure . o. en ouman exraceuaroman noooca,a. ecosa-on rea wcasonnc uunaereo wenauarsee an enz nmone-enau,rea.o. ore manuacurer’srooco.am conons asere con es werereareor - anass uner reuce non-reouncsnre cmonxeo wns wuou re™uc sanm aeen re.ucn aenermosera.o. or oocaam,aes. n oo. recom-nan arnoenusm oanuman csene exoroarceomuaarnoman no or- anass uner reucn or non-re werereare uerermosera. no wuucn™ conamons wu ™ ame a. no. or wou reucn aen.a eeucnenermoser ean a°or mes uner reucn conon wereenaure mm, wes or n m onu saems.easm weerseoae o wneoreoaers o-nocn-e mn-se-sr as mn-es. sanar.ecrooress was conuce usn a- onse a or aroxmae our.es eureoc™ mn-eevce a vos a. no. were sane usneoe™ sann reaenermoser, our.reocero. ns woreersesr wanass ceorrnuce usn a-eureoc™ mn-eevce a vosor s eo nroceuose memranes usneo™ ssemermo necr,uaa.o nno.n . accowreenn™oe manuacourrer’sounsrucons.emranes wereoce oowe ncuaon w m on r a roomemeraure w san,soen m o .ween™- m. anemores oresoe conro mnues w . ween™.e anes were wasereemesor an-uman an mranes werencuae w -conuaeoa our a roomemeraoure wm saa-nr.c,emranes werue weas ae:reemnesoocrn munueeror .ween™.e sna was vsuaze usnuerna™esc s w ser,a. no. accornoe manuacurer’ ouermo ezureoss snsrucons.maes were caure usn suusr nae oemnman noure ssem e cs,e a. ne soorseosmeanounoe exraceuaroman ouman suc as oumanr conraro oer s e eo.e. r oecr . reon o onze e ss oeresenscosurenvovese - reuce,eseern. cososa uesn us rencomnaanseuma cno nerenormsnon-enaure,near, eecveno ures-.nrmae ss oeresenscosure e seccu- oe s oreren seces was asonvesae. cnom n exraceuaroman recomnanroensncun woereus coaeesu osn-wuree ,umaaens auer ceoncen,ra moounse ourme.a,e asn w ra ure w aesveae cover an sore aoovern ere covere wasnuer w. ween™..e nexa,aes were wasex w wasnuerorour ao.urn aes wereoce w a-ree nneocnueroenca encuaonme,e an- ss wereue concenra e concenraons.nre,e an- ss sarn uer waso rn was n an seraueno. .erocn,eocnoe corresemonoven wroems.ea wees wse arne covere w o an a-esv ssuons wereranserroe orour.urnermar anon eaes cover anncuae a conuae wa cuaon,e seconar anooa an-uman, eocconuer,osuen weocnuer.aes were wasoex w s owe seconar anoncuaonor anoerour a .ere onar an coemunmcunaescoenn, suaessr waeere wearsmeosxer w. weasumnuer an ae w ecraaxx a nescence sna waseece mso sownnu n. e cno res-,euman an- ss sowe cross-reacvo anus-esus ss,a avne v aerowern ann ac, avs soow mnouse su anrac raeasmon resonan. assa,ooruman an c ce ss s nomous ow ure . an- nowe a ver sowssocaon rae asncae e raeure. nn o o arner-oeerm anneoees reoo cne os exressnareeruneca anon- was ass aenssoes,e comer e ow e o. areeneram cnees wee ereecran osenranrusneccaeon ws onuenn a o an- ss, ours aerransecon, ces man muans oecamne. anure .n were5coece an sane w an- anoesure uonor mnurees, a× room ceems wereareuren.cuna-e w a annco recees woerreocune anno sarenenmeus wero n s aann aneu anencuae w cesor mnues once.er wasn umanc reonoeen,a r, we-rceon muxeae w sec coensar anoes reconzne ces were wasereemes,oowe resusensonno. oer- samnnno-or mnues, - souon os cnomcn susra cences,a . an nneonure wa anure, cone .., , -, , , , ,s a nno aeceosernrunncaonne csene-rcoman. - reon o on ces wen e - rs wereruncae,mna - nno nvoves roens.merenarrooemon. oerencomar, an anoes, oun wo anoer reono runcaons,mnann oese an as aeono a reon. nono an o oeso nvovese- anor nno manvove -ere runcaons,ncana reamen w eo aumormrna- amno acs. o.nesoaea c ownon o.ne xenora moe . arcnoma wereas no sow ecacns moe ure xame ,ae- re ces a,ssnacus wnereero-rme- w,er-omea sca .nre,umor ces were seeenoe- -,-, --,.n serauenuons sarnweromae ns ovenrnoe.e nexa cu,eusren anoes were e seraueesn ano was aeoe w meum. o ces. es conann arorae aerenare anranserr-e ceoseenc onerorecre.oassaecores wereaenrom -° sorae ces areusaweaou - mnues.e eeecoarw cens, weer veaawen a° waera unnsece.e ce susenson was mxene va en w uas anenow an aane an. m vsu caes waesranserreeooreeruoea csosananneco.r me asssauer.eue was mxe ennvern. reaen reservor an oe ce susenson wa-ss suesnseensoon a weree wranserreo a sere ces an anoes.e wasace onea es conannare °n a ncuaor.o es aneae wasncuaeorours a reare an reconsue anu ersuaerr,aee ao r-oomo-em™erucerase assa reaen wasres ee, oo-o-™ucer aure.sn a manua mucanne c ase assa reaen was aeoe assaaes we avonuremannesc aennceu wase mse.asuereae wasncuae a amenemeraureor– mnues anen xermens w usn an aae rea aesr w we as coowrr-eseonumnn vesecrsenocne rea caaes. coron o an an was reaceor ansn wc,c weree or ano-eenen ceuaraocoss .susraen ese ss u noe verson ece n vron auroese,e an- .non rane.noes’ soc n was se -resonsees conannare an eecor reor ra ue an aeoe wes , cewe over er- ces. -- cesare were seee a o:. n.e eecor ces - ces weresense a an: rao exressonncen varouss c aa cnceecr ceosnnoers m eacroae acv, we assesseeeve o o an- xressn o evauaeemac one ecac su ss. wereaseevsera oe cen suruacree, exre-sson-n ce-s sow aneeo-wes-s exresson,eve o exressonsern-,oowe -- an smar-.e . -aree assas wereerorme weromea sca ., ur cees,nc,un- -- ure anure-uerane, --umor cesure-oweure , -- ure-meane or.n a,esn anoes r orane wer wee sreee seeranouee-wne.aeus oovnesrn sar.nero nmex ne wenos conann a curourrea mee aumer.enar oe seraueesn ano was aeoeve osus aracevn aaunrses--,e ce - ces as. annooweesr a ancv o sowe a an - c n --o eac os sero awne arons. une.u nre,,e oewo anoes an are cose - an - ces, wu -- ere was aer maxane - - ce c mae exane eower exresson o on - sa ss veo.wonsnur aecv, aan vsersons oe an anoes an a s --, -- an - cesn mameare exeneremnen on.eesec rnec verooaa suese mecansm oe anoes asxsares wseorne oerorme wa.snorc. -e-own usn smanerern s an smar s ermose ces an - ces wereransece w eoecamner r,a or conro s ermoser,a exressoneve wasaneseercons. ours aerransecon, ces were coece an were use aseare cemsnne o awss caso.mer.nce nocown was conrme, ces ces aexrressonnoevceo own was aneermne onure-.,×5- ces- wer an -- c receorocn ano uonor m encuae w an conuae an nues a roomemeraure.ue - mxe w ce-s.,er s-aconnnuaoer an m-nues, c aenso weresoeen uon were resusensonno e wasereemes,oowe es were a o-mno-cnomcn- souon uon. anaze wownoa vzaean on sne caenos™ anveow c comeer oscence.aa were o s exruesssraoennnur-e-,ra annseco-n w es. ces. s eo a sncan reucon aocsossus oraen anures-n,o nocown s ncrease acv ae -- an - ces.n -- woun arsoaveer acvan an aso sow acv ev versons oveo en oreorn, o a asnusr.ae anure,n comarsono an ,e -- an - umnoro ces an aveos acv aans oeese re assusas.nnccaeeansoces a co e ewv cnen o wen onor s man ex ccanress eonnasncneee m.axma sna exresson o on -- an - mroae acv,eer acv.ss conssen w a exane reaveow acv. aa sowna er exressoneoeower w an ane-n vvo ano m.ecraensmw anoseecoena enancn acv was aso vereermnus an ae c anoes comrsn eer ae-erm -ermnus oc or ae-ermnus an ae- comnaures ooc wereeaneroaese n.oonc an sowencrease an-umor acv eseaa suesaoenuee an- moueure . .secc o c o an- anoes maencrease nn an a anern munsnecomca ann moaese croemorresne an an- anennnoman exres useorrean cancer assocae w -erson. wereae-en n ceaso e wn serxe-weerenaease anno s mmacuroaea wesne sx-wema,aes.w-o mon ces concenraon o norours.es were w ae oursne ce cu ase w anreae w conesor -ammaearaneu,re m-e-um. aonr cemerenaeoanr,a ces werereae w nm erenaon, ces werereae ne, - .or ce earane,--. w nm-earane,-- an nm- waseweocree w runnn. maceroaraee cesaoc-oss assa, ces were coece wr an a nmor mnues - were sane w roo nvroen, sa a roomemeraure.e or macroaes were ense. wes weerer wacaeseo wenvro anen, resuse a or mnues a roomemeraure. macroaes were mx nene comee meum. orncae anoee w -- ces ae: rao o: anreae we resusenenesorueoru wrs.ereunocnu oao-n, ce.se wse wreer wea asnae w an ano comeer anoueosve ces wereae ze e ure sowsa - cese aseaocose macroaes.reamen w an c renaeno an macroaes uonreamen. ones. - ces sowe ureuaon o aer . maecro caeess s soowwee u urereuuaaonon o o an ano awenrrereuaamen w - anreamen w - a on o aer cess-us-raenn-ure. an,o an macroaeseaoaocoss oare xame-n vvo mecan . e mecansm sm o acon susraen o aucon wasurernvesaen vvo. e seconar an re wcse verson o waseeceon o we as exece,e verson was no. sus ae an-umoor re ecoemcnnaneuman--. xoewnoeverar, asumuosraenure, asose ane-umoruncons ac r moe.eseaa suesa c receor-eenen acv.ncee mce onas meo msacuroaca a ce, ce an ces,sc-eenen ceuar acvse meae o s acuesvrae aan. nsure-,- ce asnuoeersan an sowe a eve ane an a meumeve o acv aans e an -- cesme eern vro acv, an .rea.nm ceenseowoer comanee.euomrroesr roenrenssoon ne. - an-ueeraone a,a arna reso-nse-n.mn xeneoraaneu xmeonro mraoe m woe ure rownon o ure- aumor or mouse m owerane. --,.na acnroae sann,umor samesncun , , xearan-emee.am-es- were w seraen ceoe wceroem moeu xseeno mra moes anorman- oowe e seconar ano- ure .e acroae marer eree o macroaen re was a correaoneweene xenora moen wcraon a annoeesoreenacme oneo a a cnomoeees r.enresseon, ma-c- sowe massvenraonnoeumors conrm roae xenora moen wc anoes sowee a.-ne -- an.n macroae exe a meumeve o ma umorrownon, xenora moe sowee macroa croaenraon. an sowe aer exresenraon an noumorrownon . overa sonn mos oeumors conrme .owever, ure, we oserve a correaoneween anoes ecac an macroaenraon eumorse.se.aan excareessoan ane macro anaeonroaenocn conuvov reesr mesaecnro cnacenraonno aceve om aomarerso xame-areamen resu. sann exressonn seeceumors eox unresesrsonan we a enxreosseosn arev maenmce a ocnrosseeren ca cnacneceres, we sane ovusoocs, ca - - anroz rssue mcroarras ocan, ures -.ne en coon cancer mcroarra mcroarras, ano s ovusoocs cancerssue cancer owe osve sann on ovar cancer ,aer somac cance,rrea.s canceare., uee crouns cramnceere.e,ea an nec cancer , an omaxea an nec cancer mcroarras conann overa ana neecn s caamnceres sanons wve. r aereervoa m seaonn.o on ver ceo coono cna cnacnecre mrcrreovaarreance w,a wseo swa,n we wc mrozene couoen coanceer an arraens eno seo,w aeoenaosveomare arno s saannnn. aeseaa sueseeosve e cncar n cncancaon o canceresor ae-asu amnmarrea omen. umors s ae- ummar o umors s rsa oroenraso uan ss w weere oane e vaoruson meo ao, mxn eua voumes -aacoe sou s :on. crsasrewn. m ,. mmazoe, m m-e, m-ucose, m-annose, m-ose, m-ucose, croroaecceon-, c-ruscaossam wenree,enerawvranserre,o a an souonw ov moeruo .or recanncreaseo w r w e aa ses were cov , an wv . -.aa wa ece aeuroeanncroronaaonac eamne an vanss,r.oc.e asnse uusn asc,. acars ,- uenn,., e a. rscuaovr,s..,-ca.rs , - rome cea crrsas sruc,ure w-as s,o uvsen ao mmocec muoare resaecneemraen usnaserco e a., vans e a., oxvo:. ... .eom uscn moao-mumer oomse,.owan,.oo, cars , - an res wereu usn ursuov, e a., cars ,- o-crsas o ene w anemac were reneo. resouon aer mernreeaasesae. ae aaoecon o .e., aearso surroun- an,oeorme ane cs reeneo-nr ocoem vaarna oe reon. wec ma o exaneorms a-a cnnnnno a anroo sveow wsnsoceao oe roen oramee awno ur reon oe s aso conruesoennno rae.ur wercmo are,eares aenn acuesuaeau orm a s,re., , an comee w eac oer,s exece ramewor o m coanr srruuceuroe anenaven smarnn an.s aso unueae ese srucuraaa suoree ao roen. vvo eca n oese an- ss anoenn ec c. nvovenos-crnseraac sornucure reveae amno ac resues o an a are corresonaneo sow:seu amreno: ac. resues oe varae reon o .e., ae anerac wuman . eosonocaonesues osonocaonesues ner sance eosonocaonesues osonocaonesues ner sance eosonocaonesues osonocaonesues ner sance arene reneneraconsnesese.ncue π:π π- an π:caon e co-crssaa sarucs ounree reonreesnenravcea eex.ame o varraoeon-roenneraconseermnerom eueoe ener mnmzaon seerormennunceresannce an. ener vaues are xamenn – asnoumanzaon an caracerzaon concenraumonansa o m re.comaensan werero coevnesre we wre co aaees ovnea-wee c aes aoe overn.e nexa,aes over an sore a .a were wasex w wasnuer wo. ween™ ncuaoens wmeree,eoce w reerenace- aree n wasnuerorour a .urne neocnueroencaen conocenesr, as we aseumanze varans, wereue concenraon was n an serauenaonos..nre n,.e aner-ocn s,es sarn uer was removerome wes an o a ocn oe corr n- ssuons wereranserroe orour.esuornnn wes.aes were covere w aesveaes cover anncuae a conuae waesrmuaer annonc wuaoen,oec secnonar anooa an-uman, ocnuer,oowe seconar anoncuaonour aenro.eares woere wasoex w seconar anoncuaon,ae ur a .ere o cem s were wasex w wasnuer an ae w ecraaxx aumne nsce.n susraeermoser.eumnescence sna waseece esxceusroaren aunre, a,u wmacnze so vwarean res ou sowe smarnno roenns assa cenno recomnanuman ae . vaues arerovenae. varans n varans n exceor , wc sow , manze varans sowe smarnno s assa.ncee amno ac canees renucenn an maxmumnn snan morance oramewornno n aon areo aeeram.ewor,smese vaue comareo arer vaues an ae esenenae. oe name n o ax . . . anumanze varans areresenenures. an .no con acvor . n an. n were seece as. ns coseoe an. ns cosecoeneraaone o oserve.susraenures an , au a sncan r eumanze varans an a susuonneuce areoca acev, conssen wennaa.ome oe amno ac nn asramewor conruesnoeramewor an mae exanneecrease esus o assasor acvornn as an reveaumeanzee v srucureaa. ures an .e ano concenraon o. n an. n warerans areresenen s coseoe an. ns coseoeaeau. concenraon oe. se nec,e as. n o umanze varans exeee e maor exceo r acvane reerence ano exceorree ..e concenraon o. n,e acv aeare essena euvaen reuceennose re asuers ararem ceonssen wennaa as sncan umanzeow veavrearn,sose-reso,nse, anwaors,s muuar,eosn.-, carre an ou on seece somea s eer acv, we o reveaea acv. ersa smar acv orower o e acvo arcv o aneumanzeum vaanraznes v waarsa envsa auraeere asseneescre aove.esus .no concenraon o. n an. n were seece as. nns cosuereose an ana s.m nars cose acoveoaeau. ex.ce no croncenra aonn,e ma.ore o exuamanze varans acv sowe sauraon a. naonsae reaer vara an a. n.e numa cnozseeo vaeaeau. acv a. n sowe exeeer acvan .ranes , , , , an sncan reuce acv reas , an ave a uresesu asn o.n acov cono, cr wc wa enraon as on conssen w . n anum.ane nzen w vean rrea sna esa. ec aere asres.en nen coseoe an. ns coseoeaeau. s o um e concenraon o. n,e maor ano an ezxece varoarnse exe. smar oreer acv ane reerence sncan reuceenno asersra cmonewssoren m wuaonennaa as nase one aove resus an umanz . on e varans were rane accorn or eaxaa,me, acv anor acv. , , a,se on, nnaa, aearsa , , , an , we , , ave a as smaro oreer an aver aeasmaxa,s s, , , , , , , ereore,ase o maro oreeran . , , ,nnn,aa,, aears,a , , , , , ners. , , an reresenees varansaesen onne anne mnax cumrvuemnn snamax o seece umanze were sresenenae.enn anmax ae normazeoe reerence ano . aersannaon aersannaon max aersannaon aersannaon max , , , , , , , av , , , , , , , an a eeee ascv o acv.umanze varans a. n an. n areresenen aee: ana aecv. meeaa was normazeoe reerence ano . es vaue a.n.asure a. n an. n reaveo ranease on . n . n . n . n es vaue a.n. ranease on . n . n , aearsa max reaveo , , , ,, ,, an, a,veee,s , ac, , aes anae summarzee acv o uv. . n an. n.eaa was normazeoe reerence ano manze varans a ae: acv measure a. n an. n re . es vaue a.n. aveo ranease on . n . n es vaue a. n. ranease on . n . n xameo-cr –saeuzeancoen a onaes vs ac res arae reon o wuman reveasa amno anuuerse os- a.nmno a arecn r ceosseu ceosn oac w-e- a reeoanr ooenseeaenernaoc aconuo aesser exen, wer vovene am eas aearsaeres no sncanneracon w same or oe r ve ce ros amuees o no ren ae ossnass an-. anassncaea - anoe en some or anerac o .ereore, , , an ma nce var n amno ac resues ouman eneor . asonoe reaonns oave sm.arsr woeer, sensc aes , varsa enxsecavea varans ,s execea varans aso e smarroeres as n anmeneweene varae reonnoe reon o . :, :, : osr o -: waseunreerae:.e an:, was useoenerae an exemar consen men susuons ou sus seuence : carrn amno acen oe- o a orreereosoreo ans.roxmae encao eac oer overe enre ncesuosree. seue aenure,e varae reon o - ave aeasncaesne conen se arvanom e oneanc e o oer weenu orv reere ous a os en s wrere on aesnn sm o o aerr aeo ronemree ensse asr.eeseonwe - roeren a coon:o scorn.neonne marxae .er u euvaen eweenrous o wea o.ncaes conservaon neonne s mmaarrxroaerees as.eoorw ex -a romue, e muavaeenoo scorn =. an amno ac resueene asena sseo susue an mar, r o arounae or anoer oe samerou.nae maor aenoosesr oeoe s suamseureou an. amno ac resueene asenar o arou susn em sacencaesae amno ac mae a non-conservave amno ac aueon.: ae . amno e seuence, aea aave anenca eren ac seuence,ueren , an or o cro emxanaons o , an . an aremenec,a wer,eas an an aveaveen uncaue se os:, an aveenca os: an uences. wereas , an ave un areenca an aveenca ue seuen:ces. an an aveenca , w an areenca . ereas as a unue s reone mres a eve o vara eween - ncana exermens.a noenvovennn as asousrae e co-crsazaon envoveerens anson su ass aansoa vuasrraaene ncanas reon ma no eres,o co-crsazaon exermens. n anm wever a eve o smareweene o - . enca anenew aemenno aec reesrenues are sowsa amno ac resues are ese anmens sowa someeve conservave amno ac susuons.evereess, e amno ac seuence o o var anaon ma vearoanersa weasn aso ana as we. nsse : a ze. vara n : o eencao oa o . var mos varanssencaoa o : exceor amnano ascavn a seuenceusraen : an : a eacncues one eve srusuon. : are wa usrea oeenrs vavarea onnes oravweo an amno ac susenucaonos.aar oaonsn e , : an, o: an v :. . arans areencaoa o one orweoveraave one or vwaroa anmsnoav aec an susuons.eancaoa o we oersave usrae raonsn are amnoes aecn an su rsesnm uuee osn n asr seew: uee enen, scnae : .aen cn s an ae a sunune saonrceusn oco an oes:ees v. ea vraarnans ss wowass noa aece owever,e amn n someeve o varaon. reucenn an acvo a.ce su co-scrusaonszanroon euxceermne o eao a resues,,, an en conrmsa amno ac e res o arenvovennn wuman .ase on susuuosn oan aeoosron m, aam anoe acc snuns.uon aoson an amno ac nnovera,e ruesuas soremseeneevee oren sowa an aremoranor o no aea varaon maeoerae ana an n anmenreoweenvovennnouman . enre varae reon o exeemnaer en emreo varmaenes r oeon o v : ane anmen was useoenerae an exemar consensus aransure was mae.e amno ac susuon seuence : carrn ans ou v oaranes areoesreons. e enreen ore aroxmae encao eac oer over va oranes soeeceeoer. . er an acv are asousraenure reon on ex aemnmaern emewoeemnenes v oarae re vaon o : ane varae was ransure was aso mae.e anmen ac u ssuesoueonnerae an exemar consensus seuence : carrn amno e enreen asn ou oe oeo vaeranoss aroens.ereore aroxmae encao eac oer over varans seecee. var orernn acv areusraenure.nure. ans seeceorer acv areusraenures- an varans seeceorer rae varans see acv areusraenure. us ceorernn acv, acv an acv are re ncneeureave. smar acv an seuences, an anmeneweene varae eneornase o.e a-nmen was useoesn:era-e a an varans s:- was : carrn amno ac susuons oun o exemaors coonnsse.nsus seuence oeo vearanes. anre aereoonreo aero exmmoaemensescerncea ano eacrov oeer onverses ecnoreen oown non-mn emomens arearcuar conemae. sure,e xame-ose ranennnravenousoxc sun cnomous mone mones.eoernocaeuorxesc an oroeocos weersen car arrec oesu w uans eevrauaeensne nave cnomous ncaresearcenernssour, .eesnsn an uonauenes o su.e nave cnomous mone wa acceerae,ncreasnosn aeosneve o m.e anmsarso aemnserenravenous w or m, wasven one weeaer.eraeers m ose we,e nexose, reeanose o m wereve anma asooerae m ose, anoerwo urne su, anmas weren exoamen aenma oenceer wee. sns or oer canes.n-ca veernar sa as warrane cnca aeasoursewe e oservaons wereerormewceane an w mora, or morunen. osaecrva anomnsa unurenrwene an-esc sau examernoaoon, asnscesuseneraea, oeavor,enerao conon, conon o maor n assessmen cnca oservaons wereerorm o ssems, an sn coa.eae saomursesosose ana on non-oesn aeaass svarenme aseor eoacwn an emaac’sosrse aos,n, ev,en,. anerum oorroemaoo a ann cnca ceesmnsr ar wcerees, coeercee we are n aonnsanacess a oer m eoacose. unsceueeasurne su. anmas unerwen asca ex run or eeme sasacoror suncuson.ere wer amnaon an were reaveooserou.rouo e noes arce-reae eecs ono we oer wesne accumaeosnase, a anmasao wes remane w urne su.ere were noes aornce-arseea.eeren wnerse noor annsanecmesa ooonaaeraemnceee erser o an sues. e serum cemsrarameers werene normaor urneosnaseoe accmaonase vauesor eac anma rane arseee oonsese w aereov wee osoerevraaeons . aeas n, cno mmou os non-um aannrmaes. once weeor uo xame ceser- mo w- ueseeo .-oorecaan enu mcecre weremane sucuaneous3woo ces mon rous.orous weremreoarse reancraee arornoaxmae.. w m vme mce were ranomzenowomanaon wen one oerou3ce on una o3s-umor ,erou w ave s reace mm3ane oer reace mm.na mm onceer weera aenumeor voum mem o3rou m cmon snauree roec reecvenve vreamen w a connue, onceer ween cau usen coamseo ece on.reamen ure, reame see r oenresason o aos-uemuomromrs.anaon.s sownn xame- w-eeo-no-ma meceu wnereamncearne sucu aunnm cancer ces mon ceser mouse.enaunmeoourss re wace a-roxma neon-sma m cme3mams w, oernece ranero wmeeze annoew ooerro wus. vencee arooune soareen amnsere ure, reamen cause r aoa o sxoses.s sownn aroxmae . umorrownon w a maxmum o xame-ea cancer ce-s w meexe-o anec war mecea wncee mrermon cane sucuaneous waea an an nec mm3anmas were ranomzenowoerosuesr. mnoeusero.u seanreumoers reace aroxmae mm, onceer wee ane oer w vece ao n amnsere ure, reamen cau neor aoa o sxoses.s sownn aroxmae .nere seumorrownon w a maxmum o o snn ae -reae anmasumors aer excson were wuenrea nsoeou cmonorasnn cees v aenc we-acso cnormo aonsema osn we ore a so memumraonre m-sausrsreosu.neu-e sac xame cancer ce-s w-eeo m-oorec on ma cecea s oncer er mous wee.remenaunmeors s rueaccueane aonus aver wae vooumoe o coore mcma3 m concero w,e are m roanoemz veersnono oourrou ws.r cous sareen amnsere w ,soe a reners eecoruncon-n anesnecoman , an ac u ane corresonnsoe conro we same amno a m can,e osncreeeerrre weeo asor aoa o versons, resecve.noes were amnsere.v. c oauesrereuammoern rse creasnsoen oeuemooro sx row xeonsoes.rass swown anur oe, am wnserreaaso nno on r.uncs roensu. su e oeoervencc-meae eeco orsen vvo mecansm o xame acrou-n w- anee-o an ec mcce o-noc o suran ancesovTMmceromaconc o reas cancer cesen mn aonc ceseceer morosu wseer.emenanumeor ssucuaneous w -- a wnere am mmn3s merecerom eacm sran w, oenrece ranero wmezee,wnoowosoesro au resa.cene ar voouumroeme ewaceen sran mouse sran were amns ne seconrourom eac reresson oe xenorasemreasnoeen coenro. ms sceowwnn aur oe a,roxma causeumor a sneose an no aerumorrow oe xeno eTMaer s suorsen vvo meca rasmanenecesov mce. eecor-uncon. nsm o acon o oerven cc-meae xame- cenn an acv across aane o cancer cenes enn , e o -n-n, o - a-cross, a-ane, o ca,ncer ce,nes w-ars-,erorme,oo-rec- cancer ,--, -, , , - a , ,-,-, ,-, ,ea, , ,-, ,au,-,varan cancer--,-- anec cancer - asrc cancer - ,ancreac cancerx-,aan-, - ,- .,esosaeaancer.n anun cancer - ,-, mon cesm anumanru weraenarcvesTMe, woaseeenw,caea wox an wa rses auseen ae: a ceusowneor o a mn-uweesoaoe.cuman wac receors.es wereen wase an seee a, mnues once.erncuaon, ces wesre a waese a awcnea an con scaennraon o m anor or an-uman coeen, e w seconarexauorce.es wereen wasew aaos an or mnues on cno ce an resusenen u uer conann-mno- a mcn - va sann souon a: uon.nno ces was csseosmseeereuoosrcesecnecnec.enawensaes on cesa were anaze ano™owreamen conon.eave a was c ooece ass m ceaacnuauoeres receanvneeons or eac .oea sann w an-uman neosoeo ceonero aao was use as aosve conro ane sann w n, reave was cacuae reaveoeso as cacuae s evence e e conro. r aa oae e an- s ece anoeso r-,,nsnecunn ---os,ve can-cer c-en,esw--,o-n,ucon m,orean or e,ua- ,,,---,,--,,-,,--,-,-,-, , ,-, ,- an - . x-,-,.n,- ac across aev o acv o was assa eane o exressn e usnromea sca eav cancer cenes summarzenaencunre ,rea-sr- ca,ncer,o-o-, --, --,-, , ,, -,,ea an,ec can,r cer-eca, cancer -,, , au,,- -,--, var,- an ca-, n, ,,- -,ancreac cancerx-,aan-,a cer--,- .n anun canc src cancer -,soaeaancer , ceser we oer-- ,-,- ,- .es were seee a an o assauer wawse aea.es oevne,rnesn. ane noexea, mearom wes was remove o or noowe x:. serauonsrearesn w aesrsea auee ar.na co enceecnorra coenss oe-- wweereaawees c aonnanunearn aessauer an o ce susenson was aeer we ereesesus, .erncua ceon-,ano moeasu mrex.ae rses weorencuaeorours a o usno-eoc-raa rexaexn w2carso aaeeeoaeer w ae ans oner-awoeaes annseu,m ann eescueanc veo wuamse recore onucon =maxnamnnanme o mseconer we. ac ane oev o ex arcesvsn o cancer ce assnaese su umsmnaromea sca across a reas cancer --, - rzenaencunreeave r-, ,ooreca cancer ,--,-,--,-, , ,- , e,r-,-,a,u, -,,v-ara,n can--, , , -, anec canc cer,--,,--,-,anc,rea cancerx-,aan-,asrc cancer -,s eac - ,-,- ,- .noaeaancer.n anun cancer usnr an resusene ae concenraon ore., meoanr cee cems. wer,e co ceeces an seeeno eac we anncuae overn.e n werena concenrao exa,esn anoes wereue a e eeconrs ce os w oerre naweooewnen ax°:. w saeerrauonsrearen assauer. meum.e raoeween eecor ces anare ces use waas an:. resuussen,e enoe assa wereranserreo eac we.aes w ecor cesncuao erencuae a°ncuaororours.er aeon e,aca wese w aere euraeo roomemeraure.o-oucerase assa susrae was measure ecrananxcuxaea ae r roomemeraureor mnues.umnescence sna was unreae conro eaer.aa were anaze snao cane uon ae o wens.ucon =maxnamnna ene ene xame-nn an acv o an varans nn ouman uman reearans , o recomnanuman roen concenraon o m.comaesna wnerero coevenre wa ws coa aees ovnea-wee c aes ae overn.e nexa,aes were over an sore a° .aes wereoce wasex w wasnuer w. ween™ ncuaonme, v waransa-ree, n w waesrenueuenroerocourn au°er. a aur snarne coonccennrauone or was r nemovoeowroeme se wreas anuonn oo an.- n s.erocn,eranserreoe corresonn wes. suons werencua aes were covere w aesveaes cover an oa ane- auma°nor,our c.onuurnaee warsmarue anonncu waon,eeoc secnonar ano were wasex wocnuer,oowe seco uer.aes our a°.ere secon nar anoncuaonor anoer anncuae w oar ano cenmcuuamonne,sceanes s wuerser waaeseerxm wos wearsnuer or mnues a roomemeraure.eumnesc ,aao x a nm ence sna waseece ecraax nnosuu. msarnaen recuorme, a varans o , sowe smar enn o umanenanroen vaues arerovenure . was assesseennow o comer va.rannasranso re,×,-- ^ ces wo an erenc-- an ces ces ocn ano uonor mnues a ro uae w anc receor wereuen sannuer omemeraure.n- anoes -ouons w r a a sarn concenraon o n.moowe e aens,o. n, anncuae w cesor mnues once. recorn wzasnneurmeeanmce rse wonoee snan wnere muer, -conuae seconar anoes ces were wasereemes,oowe resusensxoenn wo ces. oer- smannon-orcn momnues, - souon uon.es were anaze ano™ow comcn oscence.aa were anaze wowo vaan on s eer susraenure,eese vara ne ces anve ces. smarnno -- an cennses o vaues are,r sowe . ovenure acev o a umanearansn -- an ces cenes wcavs asse osse an us-n ss an n -- an a, ceser we o-weaes orvoemrnea.e nexscaa, mearom. weess w waesr ree smeoevee a on or n o asosaowueer waxs a:.e s.eraen,eusonns anreaores were ae ana concenraons - wereawe anuen assa en assauer. eecor ces oe-weaes con uer an o ce susenson was aeer we ereesesus, .annernacruea ceon-,ano moeasu mrex.ae rses weornesen,c auaeorours a oo-o- reaen w2as aeoe wes o-wea n eua voume usnecraaxxcro es anumnescence was recore ure sowaeeaer a anneraonme o mseconer we. acvn --e anaeese v caersans o vaues arerov,enaur semar. xame n esasee a-nn u- v muomvo ro a mrn e- oeecum s oor eec o n mce.um manczee vu -amra wan enesearan s o,e,s mae, wasese aresveraoraores.onsan,. wereurcaserom emae wereurcase eerro -oxase mce- wees o, orono,.c maresveraoraores.onsan, orrom e anma wor waes w ceorneuocuese acnco aranooen-ereue eenvnreosn omene aae anmaacn . are anenmaserooco arove e naanounc onnma re, mce or mce weremane sucu nmaareommee a . nmas were ranomze aneous w or monumor ces. re3no exermenarous asncae wenumor voumes naecaeve co-nro. mmum aonr vo weurmee wenasr meaeaesuraerro owncse we an- ss or wsoe ore exermen oures-, mc oerwceereror wee. aoumm3werereae w , , ,u wosve c-onro- oumor soeneave conro am, onceer weeoroses.s r wneae oure, eac o , an usnrauceenumourr re an comareosoereamenne mce --umor moe. eresson aoore3exermen oures-, mceerrou w umor souenemmav we ceorenrroea ae wm, once,er wee,oros,es.susroaseven conurore or w an cnomeareaoes ooeurreeamen, enace o mce, anumor moen.uceumor reresson xame-nn an acv o varans , an nn oumaanranso rec roemcomnannauman roen concenraon o m.aes wnerero coevenre wa ws coa aees ovnea-wee cove aes ae overn.e nexa,aes were wa r an sore a° aes wereoce w sex w wasnuer w.ween™.ncuao a-ree n wasnuerorour a°.urne ocnnumere a, a an s-a ss , , , wereuene n.erocn,ernoc conncenuraeron w oas remo nveoroomwee we sersa auonno. ssuons wereranserreoe corre n o an- aes sonn wes.aes were covere w aesve secon caorve arn anoncuoaae an a-um°anor,our. curnermar anoncuaon,e ocnuer.aes were wa onuae wasuen w encuao sex wocnuer,oowe seconar ano wasenx wor an woasernuourer a an° a.e were secon oar anoncuaon,aes were ermo.ser,aao .e cemumnescen susrae nm umnescence sna waseece ecraaxx a sowuree ssmu .asrranennouurmean, aes reecom ann-anroe sns vaue,s arer,oven enne onanra onso,-- a an ces assesse ow comer.nre n o -- an ces was ano uonor mnu,e×s a^ roo cmeesm weereranucrue.ane- w an acn recoeorocnn sannuer a a sarn concenra es wereue uons w raens,o. n, annon o n.moowe -o wasnreemes w sanncuuaere, w-c coensuoare s mecnouneasr on ance.oeesr r ceecos wnezren weumanc reonoeen were mxe w ces.er sannor mnues, - saosueonreemes,uoonow.ees w reesrues anensonno o-mno-cnomcn oscence.aa were anaze wowoa vazean on sne caenso™ anveow c comeer arsnnusroaen-u-re an, es. sm an- ce sness , vaues are anroven sowue . re acev oa arcavnsn o an-- an ces an cenes was asse-sse us ss , an n -- seee a, ceser we o-wenaesro omveerna.e nsexcaa, mearom. wees were remove an o assauer was ae.e s was concenrao n,esn anoes were ae ana eecor cesns o- or we nreoawoewe anxue:.n serauonsrearen assauer. aeer we oe-weaes conannar aess cae-aunero an mx. o ce susenson was ours a ereesesus, .erncuaon,o measureaes r weesreonnsceu, aaeor voume oo-o- reaen2was aeoe n eua was rec wes o-weaes anumnescence er weo.re usnecraaxxcroaeeaer a anneraonme o msecon acvuren sow-e-a a ann- s ces,s , vaues ar aenrove snoweure smar. xame-n vvo an-umor eec o varans , an ounene axn-umor eec oe , an varans was carre ou as aouomrmea 3 em wxeree ermree. ane o wures,-,, mce anerrou w --umor soeneave conro am, onceer weeoroses.susroasevne conurroe or w an cnomeareaoes ooeurreeamen, enace o mce, - an-umor mnouece.umor reresson ore exermen oure-, mceerrou w umor aou nmm3werereae w , , an osve conro or wsoe aeae ove conurreo a, emac o, oncee,r weeo arnoses.snuucesrauemornure annesoereamenne mce umo reresson comareo xame-nn o var r moe. enn orsans an ouman aans ces exressnueccnn aen wasese aans recomnanuman or seorn comrsesm :ea ann a-. varae reon avne amno ac seuence se s we as an an-- varae reonavne amno ac seuueennccee s seeoorrn : an an an- varae reonavne amno ac seorn comnrses:e an: as-. varae reon avne amno ac seuence seu we as an an-- varae reonavne amno ac seueennccee s seeoorrn : an an an- varae reonavne amno acermnusn oo n emerza an : onoma,. n ane a anre- se-ara ane an-ners. varearse reecocns anren a aeen- aven a-o-ermnaason,eeneraormua: a s merzaonoman,ner anennnoman,ner, c a anereor assemesoorm e a aenxaveanennonmoommaern.,ner an anennnoman nn ouman an recomo rneacnomronanuman roen concenraon o m. en was coae on-we aes ae overn.e nexa,aesa weser wee wreas coeverex w w w aasensveuae cover an sore a° .aes wereoce w a-ree n wasnu er w. ween™ncuaonme, an anoes we erorour a°.urne concenraons.nre,e an- ss srearnue connceneraoconn wasuero ne ann scearea ue on ano-. s n.seurooncs wnere,reansoecrrenouer was removerome wes an covere w aesveaes cover anncuae a°ore coourrr.esuornnne werms.aes werencuaon,e seconar anooa an-um ar ano weocnuer.aes were an, conuae wasuen anoncuaonor anoerour w aase°.x wereo sceconnaru aenr,ooownecu seconar were wasex w wasnuer an ae w o aon,aes ermoser,aao .eu cemumnescen susrae nm. mnescence sna waseece ecraaxx a nnsusraennure, an an- anoes sowe smar aansoesuumsan reco rmeconmannarnoerno aenn. soween smnar on an wasese an soweowernnoa anouse rnaa no sown. sown. ecomnanroensaa no enn o an o --, ssesseenown c oomer.n anre,×o - an- enes a5ces we-ren-cua,e- an- ces was ano uonor mnues a room w anc receorocnn sannuero emeraure.n- anoes wereue wasnreemes w n an s aanen anunceur,ae w-con ceusaoer se mconnues once.er reconzneumanc reonoeen wer ar anoes ces were w e mxe w ces.er sannor mnues, - saosueonreemes,uoonow.ees w reesrues aneansozenno oa-nmno-cnomcn oscence.aa were anaze wo o™ow comeer susraenur wo vaan on sne ces anve ces. nno -- cese com, an- anoes, an , sowe er neave cene,-. areo-.ese anoes none non-mnn a emonoomenes e amreo conmeemnsaeesc.re anrovensscosure,eoown .e onnen o aen comrsn one or more anennnomans, weren aeas one o arn mo corem anrsese:nnnomansnsorooas ce surace anen- a. acea sveu cenacne c soemoermennareermnn reon avne amno eermnn reon avne: am,no a aceav se cueancne c soemoremennar an a:eav, can com:em,e :, :, : amno ac se nareermnn reon avne .eav canu ceonmce seeorn : or ac menareermnn reon avne amno eerm senunenc ree soenorn avne: am,no a aeav can comemenar :n, aeav can: com,emenar: c seuence seorn : a eerm ornn re : or e amno ac seuence seorn on avn.enn aen oerecen emomen, we:. more anennnomans comrses an amno acre sne aeas one oe one or :. euence as seorn . onee orn monre a anene on ann onoemarencse conm ermseos amne anmsn,o w aceren seueen acee aass one oe : seorn. onee orn monre aen. o an oerecen emomens, werene aeas one oe : an.ennnomans comrses an amno ac seuence as seorn. onee orn monre aen o an oerecen emomens, werene aeas one oe one o anens:n-n.omans comrses an amno ac seuence as seorn an . onee orn mn aen o an oerecen emomens, werene aeas one oe o ore anennnomans comrses an amno ac seuence as seorn an.ne onee o orn monre a anens en o: ann- n o. omearnesc ceomnr esmeso an ammennos, a wce sreenuencee a ase sas one oe one o s eorn an. onee orn monre a anenen o: ann- n o. omearnesc ceomnr esmeso an ammennos, a wce sreenue aeas one oe one o ence as seorn an. onee orn monre a anens en o: ann- n o. omearnesc ceomnr esmeso an ammens, werene aeas one oe one no ac seuence as seorn an . onee o orn monre a anens e o: n an- n o. neomraecnes cnom emromens, werene aeas one oe encaoe amno ac seuence seornses an amno ac seuence aeas :, :, :, ::, :, :, :, :, :,, ::, ::, :, :, :, :,, :,, :, :, :, :, :, o :, :, :, :, . onee orn monre ar anene on ann o: ne. omraecnes cnom emrseos amnen ams,n wo aecren seeu aeas one oe encaoe amno ac seu ence aeas ::, :,ence seor:n, ::,, ::,, :, :, :, :, :, :,, ::, :, :, :, :, :,, :, :, :, :, or :. :, :, :, .e onnen or a meonre c aonmresnnn onen or momore anennnomans, weren aeas one o anen- an comrses aeaanvs s ceacnc caomemnesnaorroeoermasn cne re suroance comemenaavrneeer ammnnno a rceo sneuence seoravnne amno ac: se,u aeeav can n : an aeav can comemenareermn nce seor avne amno ac seuence seorn : an ann a reon aeas encaoe amno ac seuence seorn an one omno ac seu:ence, .nn a:en c oormrs :. e one or more anennn onen or momoraen asn seenccnannomsaons, weren aeas one o anen- an comrses aeav c rooas ce surace avne amno ac s an comemenareermnn reon comemenareer euence seorn :, aeav can n : anmn an reon avne amno ac seuence seor aavenase amneno acca soeueeena amcven soe ca aconr co senmemenar uence seor:ee n arm ann n a onn am renoon ac seuence or :. ne o : .nn aen comrsn one or more ane ane oenne- or more anennnomans senccnannomsaons,r woeorenas a ceeas s ounreac oe avn aen am conmo arcses se aueeanvce c seanor comnemenar:eerm, ann reon comemenareermnn reon avne amn eav can n : an aeav can comemen o ac seuence seor avne amno ac seuence seo areermnn reon aeas encaoe amnrn : an an amno ac seuence or o ac seuence seorn an one o :. one onr mnor ae aenn co: emnr. nsnn onoem oar mnso sree acnennnomans, weren aeas one oe an comrses: cansorooas ce surace anen- aavne aamvnno ace a smeuneon acce as s seeueonrce as seorn :, a e amno ac seuence as n : anor a avn.nn aen comrsn one or s meororn : one or more anennnomans see acncennnomans, weren aeas one oe an co ansorooas ce surace anen- a m avne aar mvse nns: o ace a smeuneon acce seuence as seorn :, a e amno ac seu as seorn : anor a avn. one onr mnor aee ann coemnrnsnen n ocne oe a m os ar s me nsoro ser e acnn ceannnnsoo:mroanso, waser ceen a sureaacse o anne oene an com - aavne aar mvse nns: o ace a smeuno ac seuence as seorn :, a e amno ence as seorn : anor a avn.nn aen co amc seuence as seorn : one or more anenrnsn one or more anennnomans, weren aeas one oe an comrsnomans seccansorooas ce surace anen- aavne aamve nns: oe amno ac seuence as seorn :, a e ac seuence as seorn : anor a avn. one onr mnor a am ee anno n co a emc nr se nsnuen n ocne oe a m os ar s me nsoro ser e acnn ceannnnsoo:mroanso, waser ceen aeas one oe an surace anen- a com avn arvsens:e amno ac seuence as seorn :, a e amnoe a acmn soe acuen scee ause snece aosr senorn :: anor a avn . one onr mno aen comrsn one or more anennnomans, weren aeas one oe arne a cnomennnomans seccansorooas ce surace anen- a arses: avne amvnno ace a smeuneon acce as s seeueonrce ans seorn: an :, a e amno ac seuence as seor or a avn.nn aen comrsn one or more annen : one or more anennnomans seccannnsoomroanso, weren aeas one oe an co as ce surace anen- a m a arvsens:e amno ac seuence as seorn :, a ev anmnoe a acmn soe acuen scee ause snece aosr seorn : anor a avn.nr mno aen comrsn one or more anne : one o nnnomans, weren aeas one oe arne a cnoennnomans seccansorooas ce surace anen- a mrses: avne aamvnno ace a smeuneon acce as s seeueonrce ans seorn: a :, a e amno ac seuence as seo nor a avn.nn aen comrsn one or morer anne : one or more anennnomans seccannnnsoomroans, weren aeas one oe an comrses: oas ce surace anen- aavne aamvnno ace a smeuneon acce as s seeueonrce ans seorn: :, a e amno ac seuence as seo anor a avn. onr mno aen comrsn one or morer ann : one ennnomans, weren aeas one oe arne a cnomenrsens:nomans seccansorooas ce surace anen- aavne aamvnno ace a smeuneon acce as s seeueonrce as seorn :, a e amno ac seuence as n : anor a avn.nn aen comrsn one or s meororn : one or more anennnomans see acncennnomans, weren aeas one oe an co ansorooas ce surace anen- a m avne aar mvse nns: o ace a smeuneon acce seuence as seorn :, a e amno ac seu as seorn : anor a avn. one onr mnor aee ann coemnrnsnen n ocne oe a m os ar s me nsoro ser e acnn ceannnnsoo:mroanso, waser ceen a sureaacse o anne oene an com - aavne aar mvse nns: o ace a smeuno ac seuence as seorn :, a e amno ence as seorn : anor a avn.nn aen co amc seuence as seorn : one or more anenrnsn one or more anennnomans, weren aeas one oe an comrsnomans seccansorooas ce surace anen- aavne aamve nns: oe amno ac seuence as seorn :, a e ac seuence as seorn : anor a avn. one onr mnor a am ee anno n co a emc nr se nsnuen n ocne oe a m os ar s me nsoro ser e acnn ceannnnsoo:mroanso, waser ceen aeas one oe an surace anen- a com avn arvsens:e amno ac seuence as seorn :, a e amnoe a acmn soe acuen scee ause snece aosr senorn :: anor a avn . one onr mno aen comrsn one or more anennnomans, weren aeas one oe arne a cnomennnomans seccansorooas ce surace anen- a arses: avne amvnno ace a smeuneon acce as s seeueonrce ans seorn: an :, a e amno ac seuence as seor or a avn.nn aen comrsn one or more annen : one or more anennnomans seccannnsoomroanso, weren aeas one oe an co as ce surace anen- a m a arvsens:e amno ac seuence as seorn :, a ev anmnoe a acmn soe acuen scee ause snece aosr seorn : anor a avn.nr mno aen comrsn one or more anne : one o nnnomans, weren aeas one oe arne a cnoennnomans seccansorooas ce surace anen- a mrses: avne aamvnno ace a smeuneon acce as s seeueonrce ans seorn: a :, a e amno ac seuence as seo nor a avn.nn aen comrsn one or morer anne : one or more anennnomans seccannnnsoomroans, weren aeas one oe an comrses: oas ce surace anen- aavne aamvnno ace a smeuneon acce as s seeueonrce ans seorn: :, a e amno ac seuence as seo anor a avn. onr mno aen comrsn one or morer ann : one ennnomans, weren aeas one oe arne a cnomenrsens:nomans seccansorooas ce surace anen- aavne aamvnno ace a smeuneon acce as s seeueonrce as seorn :, a e amno ac seuence as n : anor a avn.nn aen comrsn one or s meororn : one or more anennnomans see acncennnomans, weren aeas one oe an co ansorooas ce surace anen- a m avne aar mvse nns: o ace a smeuneon acce seuence as seorn :, a e amno ac seu as seorn : anor a avn. one onr mnor aee ann coemnrnsnen n ocne oe a m os ar s me nsoro ser e acnn ceannnnsoo:mroanso, waser ceen a sureaacse o anne oene an com - aavne aar mvse nns: o ace a smeuno ac seuence as seorn :, a e amno ence as seorn : anor a avn.nn aen co amc seuence as seorn : one or more anenrnsn one or more anennnomans, weren aeas one oe an comrsnomans seccansorooas ce surace anen- aavne aamve nns: oe amno ac seuence as seorn :, a e ac seuence as seorn : anor a avn. one onr mnor a am ee anno n co a emc nr se nsnuen n ocne oe a m os ar s me nsoro ser e acnn ceannnnsoo:mroanso, waser ceen aeas one oe an surace anen- a com avn arvsens:e amno ac seuence as seorn :, a e amnoe a acmn soe acuen scee ause snece aosr senorn :: anor a avn . one onr mno aen comrsn one or more anennnomans, weren aeas one oe arne a cnomennnomans seccansorooas ce surace anen- a arses: avne amvnno ace a smeuneon acce as s seeueonrce ans seorn: an :, a e amno ac seuence as seor or a avn.nn aen comrsn one or more annen : one or more anennnomans seccannnsoomroanso, weren aeas one oe an co as ce surace anen- a m a arvsens:e amno ac seuence as seorn :, a ev anmnoe a acmn soe acuen scee ause snece aosr seorn : anor a avn.nr mno aen comrsn one or more anne : one o nnnomans, weren aeas one oe arne a cnoennnomans seccansorooas ce surace anen- a mrses: avne aamvnno ace a smeuneon acce as s seeueonrce ans seorn: a :, a e amno ac seuence as seo nor a avn.nn aen comrsn one or morer anne : one or more anennnomans seccannnnsoomroans, weren aeas one oe an comrses: oas ce surace anen- aavne aamvnno ace a smeuneon acce as s seeueonrce ans seorn: :, a e amno ac seuence as seo anor a avn. onr mno aen comrsn one or morer ann : one ennnomans, weren aeas one oe arne a cnomenrsens:nomans seccansorooas ce surace anen- aavne aamvnno ace a smeuneon acce as s seeueonrce as seorn :, a e amno ac seuence as n : anor a avn.nn aen comrsn one or s meororn : one or more anennnomans see acncennnomans, weren aeas one oe an co ansorooas ce surace anen- a m avne aar mvse nns: o ace a smeuneon acce seuence as seorn :, a e amno ac seu as seorn : anor a avn. one onr mnor aee ann coemnrnsnen n ocne oe a m os ar s me nsoro ser e acnn ceannnnsoo:mroanso, waser ceen a sureaacse o anne oene an com - aavne aar mvse nns: o ace a smeuno ac seuence as seorn :, a e amno ence as seorn : anor a avn.nn aen co amc seuence as seorn : one or more anenrnsn one or more anennnomans, weren aeas one oe an comrsnomans seccansorooas ce surace anen- aavne aamve nns: oe amno ac seuence as seorn :, a e ac seuence as seorn : anor a avn. one onr mnor a am ee anno n co a emc nr se nsnuen n ocne oe a m os ar s me nsoro ser e acnn ceannnnsoo:mroanso, waser ceen aeas one oe an surace anen- a com avn arvsens:e amno ac seuence as seorn :, a e amnoe a acmn soe acuen scee ause snece aosr senorn :: anor a avn . one onr mno aen comrsn one or more anennnomans, weren aeas one oe arne a cnomennnomans seccansorooas ce surace anen- a arses: avne amvnno ace a smeuneon acce as s seeueonrce ans seorn: an :, a e amno ac seuence as seor or a avn.nn aen comrsn one or more annen : one or more anennnomans seccannnsoomroanso, weren aeas one oe an co as ce surace anen- a m a arvsens:e amno ac seuence as seorn :, a ev anmnoe a acmn soe acuen scee ause snece aosr seorn : anor a avn.nr mno aen comrsn one or more anne : one o nnnomans, weren aeas one oe arne a cnoennnomans seccansorooas ce surace anen- a mrses: avne aamvnno ace a smeuneon acce as s seeueonrce ans seorn: a :, a e amno ac seuence as seo nor a avn.nn aen comrsn one or morer anne : one or more anennnomans seccannnnsoomroans, weren aeas one oe an comrses: oas ce surace anen- aavne aamvnno ace a smeuneon acce as s seeueonrce ans seorn: :, a e amno ac seuence as seo anor a avn. onr mno aen comrsn one or morer ann : one ennnomans, weren aeas one oe arne a cnomenrsens:nomans seccansorooas ce surace anen- aavne aamvnno ace a smeuneon acce as s seeueonrce as seorn :, a e amno ac seuence as n : anor a avn.nn aen comrsn one or s meororn : one or more anennnomans see acncennnomans, weren aeas one oe an co ansorooas ce surace anen- a m avne aar mvse nns: o ace a smeuneon acce seuence as seorn :, a e amno ac seu as seorn : anor a avn. one onr mnor aee ann coemnrnsnen n ocne oe a m os ar s me nsoro ser e acnn ceannnnsoo:mroanso, waser ceen a sureaacse o anne oene an com - aavne aar mvse nns: o ace a smeuno ac seuence as seorn :, a e amno ence as seorn : anor a avn.nn aen co amc seuence as seorn : one or more anenrnsn one or more anennnomans, weren aeas one oe an comrsnomans seccansorooas ce surace anen- aavne aamve nns: oe amno ac seuence as seorn :, a e ac seuence as seorn : anor a avn. one onr mnor a am ee anno n co a emc nr se nsnuen n ocne oe a m os ar s me nsoro ser e acnn ceannnnsoo:mroanso, waser ceen aeas one oe an surace anen- a com avn arvsens:e amno ac seuence as seorn :, a e amnoe a acmn soe acuen scee ause snece aosr senorn :: anor a avn . one onr mno aen comrsn one or more anennnomans, weren aeas one oe arne a cnomenrnnomans seccansorooas ce surace anen- a avses: avne amnno ace a smeuneon acce as s seeueonrce ans seorn: ano:, a e amno ac seuence as seorn r a avn.nn aen comrsn one or more anenn : one or more anennnomans seccannsoomroanso, waeren aeas one oe an com s ce surace anen- a arses: a vne amno ac seuence as seorn :, a ev anmnoe a acmn soe acuen scee ause snece aosr senorn : anor a avn.nno aen comrsn one or more anenn : one or m nomans, weren aeas one oe arne a cnomenrnnomans seccansorooas ce surace anen- a avses: avne amnno ace a smeuneon acce as s seeueonrce ans seorn: ano:, a e amno ac seuence as seorn r a avn.nn aen comrsn one or more anenn : one or more anennnomans seccannsoomroanso, waeren aeas one oe an com s ce surace anen- a arses: a vne amno ac seuence as seorn :, a ev anmnoe a acmn soe acuen scee ause snece aosr senorn : anor a avn.e onr mno aen comrsn one or more a :, or on nennnomans, weren aeas one oe arne a cnomenrsens:nomans seccansorooas ce surace anen- aavne aamvnno ace a smeuneon acce as s seeueonrce ans seorn :, a e amno ac seuence as s : anor a avn.nn aen comrsn one or meororn :. one or more anennnomans see acnceannnomans, weren aeas one oe an com nsorooas ce surace anen- aavne aamvnnrses: o ace a smeuneon acce as seuence as seorn :, a e amno ac seuen seorn : anor a avn. one onr mnor aee ann coemnrnsnce n o ans oe se m oar mor nsor sen e acnceannnn: soo.mroanso, waser ceen a sureaacse o anne oen-e a an co avne aam mvnnrses: o ace a smeuneo ac seuence as seorn :, a e amno ac nce as seorn : anor a avn.nn aen co smeruence as seorn :. one or more anennsnn one or more anennnomans, weren aeas one oe an comrse omans seccansorooas ce surace anen- aavne aamvnns: o ae amno ac seuence as seorn :, a e a c seuence as seorn : anor a avn. one onr mnm or ano ee an ac n co s eme nrue nsnnce n o ans oe se m oar mor nsor sen e acnceannnn: soo.mroanso, waser ceen a seas one oe an c urace anen- a o avneamvnrses:e amno ac seuence as seorn :, a e amno a acmn soe aucenc see asue senceo ars senorn:.: anor a avn . one onr mnor aee ann comrsn one or more anennnomans, weren aeas one oe an comenrsensnomans seccansorooas ce surace anen- aavne aamvnn: o ace a smeuneon ac seuence as seorn :, a e amno ac seuen ce as seorn : anor a avn.ne onr mno aen comrsnce o anse se or morn :. o ore anennnomans, weren aeas one oe arne a cnomenrnnomans seccansorooas ce surace anen- a avnses: avne a e amno ac seuence as seorn :, a e a mno ac seuence as seorn : anor a avn. one onr mnm or ano ee an ac n co s eme nrue nsnnce n o ans oe se m oar mor nsoren anennn:o.mans, weren aeas one oe an co seccansorooas ce surace anen- aavne aam mvnnrses: o ace a smeuneon acce as s seeueonrce ans seorn: :, a e amno ac seuence as seorn anor a avn.nennonma anesns o one an or oerecen emome:ns,. werene one or more anen.enn aen o a moreeav can varae reons. varae reons areanra o oerureceunma emomens, werene one or moreeav can. vareane reno anen o an oerecen enmzeo.mens, werene one or moreeav can.enn asen co om arnse oumeanr oecreumnan emzeorammeenwso,r w reeons. more anennnomans comrseseumanzeeavre cnane v aareaase o rne oe one or comrsne amno ac seuence s eonacone :, : or eo:r.ne amno ac seuence seorn . moere annnen aennn o anom oanse comrecresens eemuomamneznes, weerene aeas one oe one or comrsne amno ac seuen av can varae reonacone :, ce seorne amno ac seuence seorn.enn a : or :. varae reonsen co om arnse o an amenreoc aecn se emuenocem aeneas, werene one or moreeav can aeas enca, aeas enca, aeass enca, aeas enca, ac s enca orencaoe amno :e,uence seorn :, :, :, ::, ::,, ::,, ::,, ::,, :,, ::,, ::,, ::,, ::, :, :, :, :, , :, :, :, :, :, :, :, :, : :, :, :, :, :, :, :, :, :, , :, :, :, : :, :, :, :, , :, :, :, :, :, :, :, :, : :, :, :, :, :, :, :, :,.enn aen o an o, orere :. varae reons comrse amno acce snu esmuoonms,en as, wonesre onreee onoen osr mnoreeeav can seuence seorn : amno ac :, , :, :, :, :, :, :, :, :, : :, :, :, :, :, :, :, :, :, :,, ::,, ::,, ::,, ::,, ::, :, :, :, :, :,, :, :, :, :, :, ::, :, :, :, :, :,, :, :, :, :, :, ::, :, :, :, :, :,, :, :, :, :, :, ::, :, :, o , :, .enr :. s a aons aen o an oerecen emomens, werene amno ac susuon oson,oons seonece,romoson,oson,oson,oson,oson, ,oson,osonos,oosnon,os,on,oson,oson,oson,oson c oson,oson,oson,oson or.om s aen ana onon s ae onerneo se o. ec aen oroerecen emomens, werene amno ac susuon oson,oson,osmonos,oons,onoson,oson,oson,oson, ,oson,oson,oson,oso,nos oorn com,oson,oson,oson.s ae anons aonen se oec aen oromeorseceonn, emosoonmen,so,s woernenanon ,eo asmere ono no. ac, soussouon oson,oson,oson,oson, n, ,oso oson,oson,oson,oson.ennn a,enos o aonn o,oesreocnen o erm coomnaonereo. varae reons comrse amn mens, werene one or moreeav can :, :o ac susuonsne amno ac seuence seorn :, :,, ::, :, :, :, :, :,, :, :, :, :, :, ::, :, :, :, :, :,, :, :, :, :, :, ::,, ::,, ::,, ::,, ::,, :,:, :, :, : :,:, :, :, :, :,:, :, :, , :,:, :, :, :, :,:, :, : :, :,:, :, :, :, :,: an werene amno ac susu,ons are seec:e, :, or aoson, aoson, aos rom : aoso on, aoson, aoson, aosonn,, a aoossoonn, aoson, aoson, aoson, u a aososonon,, aoson,, aoson, aoson, aoson, v aoson, a aoossoonn,, a aoson, aoson, aoson, aoson, aoson, aoossoonn,, a aoosson, aoson, w aoson, aoson, ao on, aos son, aoson, aoson, x a aoossoo onn n,, , a aoossoon, aoson, aoson, z a aososonon,, a aoossoonnn,, , a a aoosos soonon n,, , aoson, aoson, aoson, a aoson, aoson, aoso oson, aoson, aoson, aoson, aa aosonn,, aoson, a aoossoonn,, a aooson, aoson, aoson, aoson, aoson, aosson, aoso on, aoson, aoson, aosonn,, a aoossoonn,, aoson, aoson, aoson, cc a aososonon,, a aososonon,, a aoson, aoson, aoson, aoson oson, aoson, aoson, aoson,, a aoossoon, aoson, aoson, aosonn,, a aoossoonn,, a aoossoonn,, a aoson, aoson, aoson, aoson oson, ee a aoossoonn,, a aoossoonn,, aoson,, aoson, aoson, aoson aoson, aoson, aoson, aoson,, a aoosson, aoson, ao on, aoson, aoson, aoson, aossoonn,, a aoossoonn,, a aososonon, aoson, aoson, a aoossoonn,, a aoossoonn,, a aooson,, aoson, aoson, aoson, son, aoson, aoson, a aoossoonn,, a aoossoonn,, a aoosson, aoson, aoson, ao on, aoson, aoson, aoson, aossoonn,, a aoossoonn,, a aoossoonn, aoson, aoson, aos , aoson, aoson, a aoossooo nnn ,,, a aoossoonn,, a aoossoonn,, aoson, aoson, aoson aoson, aoson, aoson, aoson,, a aoossoonn,, a aoossoonn,, a aooson, aoson, or, son, aoson a aoosson, aoson, aoson, aoson, aoson, aosoonn,, a aoossoonn,, a aoossoonn,. aoson, aoson, . vareane reno ansen co om arnse o amneo arecce suns emuoonsmens, werene one or moreeav can :, :, :,ne amn:o ac seuence seorn :, :, :, :, :, :, :, :, , :, :, :, :, :, :, :, :, : :, :, :, :, :, :, :, :, :, , :, :, :, : :, :, :, :, , :, :, :, :, :, :, :, :, : :, :, :, :, :, :, :, :, :, :,, ::,, ::,, ::,, :: or :, en:e a,mno ac su:su,ons are:, , : an wer :, or a. a aososonon,, a aoossoonn,, a aoosson, seece aorosmo :n, aoson, aoso on, aoson, aoson, . aosnon,, a aoossoonn, aoson, aoson, aoson, aoson, aoson,, a aoossoonn,, aoson, aoson, aoson, a aoson, aoson, c. oson, aoson, aoson, a aososonon,, a aoson, aoson, aoson, aoson, aoson, aoossoonn,, a aoosson, aoson, aoson, . aoson, aoson, aoson, aoso on, aoson, aoson, aosonn,, a aoossoonn,, aoson, aoson, aoson, e. a aososonon,, a aoossoonn,, a aoosson, aoson, aoson, aos on, aoson, aoson, . a aoosson oonn, ,, a aoossoonn,, a aoossoonn,, a aoson, aoson, . aoson, aoson, aoson, oson, aoson, aoson, aoson, aoson, . aoson, aoson, a aoossoonn, . aoson, aos , aoson, aoson,. aoson, aosonon,, a aooson, ossoonn,, a aoo son, aoson, aoson, a o ssoonn,, a aoossoonn,, a aoossoonn,, a aoossoonn,, a a .o a as osoosn onon, ,, aoson, aoson, aoson, aoson,. aoson, a aososonon, aoson, aoson, aoson,, a aoossoonn,, a aoossoonn,, a aoossoon, aoson, aoso n, m. aoson, aon, ao son, aoson, aoson, aoson, . aossoonn,, a aoson, aoson, aoson, aoson, n oson, aoson, a aososonon,, a aoossoonn,, a aoossoonn, aoson, aoson, aoson, aoso , aoson, aoson, o. aoson, aosnon,, a aosoon, aoson, ao son, aoson, aoson, ao son, aoson, aoson, aoson, . a aossoonn,, a aoossoonn,, a aoossoonn,, aoson, aoson, aoossoonn,, a aoossoonn,, a aoossoonn,, aoson, aoson, . a aososonon,, a aososonon,, a aoson, aoson, aoson, aoson oson, aoson, aoson, r. a aososonon, ,, a aososonon,, aoson, aoson, aoson, aoso aoson, aoson, aoson, s. a aososn onon, ,, a aososonon, aoson, aoson, aoson, aos , aoson, aoson, aoson, . a aososon onon, ,, a aososoon, aoson, aoson, aoson, aos n, aoson, aoson, aoson, u. a aososon onon,, or, a aoossoonn,, a aoossoonn,, a aoossoonn,, a aoossoonn.,. moere annnen aennn o anom oanse comrecresen emomens, werene aeas one oe one or comrsne amno ac seue seumanzeeav can varae reonacone :, :,nce se:or,n ::,, ::,, ::, :, :, :, :, :,, :, :, :, :, :, or comr:sn,rom oneo:ve am,no ac su:su,ons, aon: or eeonse s anor. moere annnr en aeeo nn. n o anom oanse comrecresens eemuomamneznes, werene aeas one oe one or comrsne amno ac seuence seorn eav can varae reonacone :, :, :, ::, :, :, :, :, :,, :, :, :, :, :, ::, :, :, :, :, :, an ereo: or comrsnrom oneove amno ac susuons, aons anoreeons. varean. e rne aonesn co om anrse o ane amrencoe acn s eemuoencmee anss s,e woerene one or moreeav can :, :, rn :, :, :, :, :, :, ::,, ::,, ::,, ::, , :, :, : or comrse , : ac s srom oneove amno.eunsnu aonen, a o anon o aneorreeceeonnn em sao ammennos a,c we sreeuenceereo. me one or moreeav can v ne amno ac seuence o a arae reon comrses amno ac resue aoson, ano aocso rnesu,e amn ao aocso rensu,e am ano aocso rensu,e aoson, amno ac resue amno ac resue aoson amno ac resue aoson, aoso , amno ac resue aoson, amno ac resue amno ac rnesu,e am anoo asco rnesue, am anoo asco rnesu,e am anoo asc resue aoson, aoson, amno ac resue ao on, amno ac resue amno ac resue a son, amno ac resue aoson,.enn aen o ano osoenrec or comnaonereo. e one en emomens, werene amno ac seuence o amno ac or m reosreueeav a coasn voanra, ame rneons comrses amno ac resue aoson, aoson, amno ac resue aoos acon res, amueno a aco rsesonue, a amnoos acon res, amue ac resue aoson, amno ac resue aoson, a no oson, amno ac resue aoson, mno ac resue a ac resue aoson amno ac resue aoson, amno oson , amno ac resue aoson, amno ac resue a ac resue, am anoos acon resu,e am ano aocso rnesue, am ano aocs resue aoson, amno oson, amno ac resue ao on, amno ac resue a comnaonereo. son, amno ac resue aoson or .eeeanvn ca anen var oa ane r oeonerecen emomens, werene amno ac seuence o resue aoson, amno asc co rmesrusees am anoos acon res, amuen aoson, amno ac amno ac resue aosons o ac resue aoson, resue ao , amno ac resue aoson, amno ac , amno acs resonue, a amnoos acon res, amueno a aco rson, amno ac resue aoson am aoson, amno ac resue aosones,u aemn ao acos roensue, am anoo acso rensue, anoo asco rnesu,e am anoo acso rnesue, amno ac resue aoson, amno ac resue amno ac resue aoson, am anoo asco rnesue, am anoo asco rnesu,e am ano aoson, aoson, amno ac resue aoson, am c resue amno ac resue aoson no ac resue aoson,.enn aen o an oerecs or comnaonereo. s ous en emomens werene amno ac susuon.s oeusne en a a aen se s ou e ae unnce o.erecen emomens, werene amno ac susuon.s oeusnenra ameewno or a renenc oe.erecen emomens, werene amno ac susuon. reeonnranmew aoen o anon oerec seeunenc eem.omens, wereneeav can varae :,r reon:, comrsese seuence seorn :, :, :, ::,, :: or, :,.enn aen o an oere :. or cen emomens, werene seuences as se. varen ane reno anesn are o: an. oerecen emomens, werene one or moreeav can.enn aerom one or more sneoman anoes. varae reonsn are or aonm o a cameerecen. emomens, werene one or moreeav can . vaenn aen o an oerecen emomens, werene one or moreeav can.r woea anne re eno n ans nen are n or ao onm m o a cameerecen. emomens, werenenn aen comrses. moenn aen o aanns o or meore.recen emomens, werenenn aens.senos ecnec c.nc. aen o an oerecen emomens, werenenn aens.enn aen o an oerecen emomens, werenenn aens. mu onees ornec monc re a. anene on ann oneomreacnena emnosomens, w anereorn onee orn monre aen comrses omanan anennn.woeonne aeens c oo an asn- an o. weerreecne eanc emooemenes c, waner ceomnresesnnn a a-eon c-omerses ason, ae one or more anen rmna merza nnomans, oona aner an c a . comreo sennnom aane.n o an oerecen emomens, werenenn aen ermnasaswoono an aemnoe a ccans an weren eacoee can comrsesn a-o- - seuen-ce oo-rmua-: ms,, or anneerarb m c- - erendneren ns,, or anneerreeaeran eren m an n are no smuaneaoeran anerena,d, eac reresens anu ansennnoman weren aeas one oe omaennnnom ora anns ans ane annnennnomnanoman , an anennn seueerenn or areneenenresen or asen an comrs...

Claims

: . one onr mnor aeen comrsn one or more anennnomans, weren aeas one oe comr anennnomansnsorooas ce surace anen- an as.es: acea sveu cenacne comemenareermnn reon avne amno eermnn seorn :, aeav can comemenar :, reon: avne amno ac seuence seorn an aeav can comem,enaree:rmn, :, : amno ac seuence seorn :n reon avne . acea sveu cenacne c soemoermennareermnn: re, ao onr eav caavne amno eermnn reon avne amno a n comemenar : c seuence seorn : an, aea :, : or : or e am v can comemenareermnn reon avn.omeanns cnom aresnno es o ac an c ama smeu no a,e c wnce se s eree unor ence aneas one o:e. one or more anennn.enn aen o cam or, werene as seorn :. omans comrses an amno ac seuence aes a seeaosr one oe one or more anennn.enn aen o an one o camso, werenne :. anennnomans aeas one oe one or more.enn aen o ca cmom,r wseser aenn ameno a aceas se onueen oce ase seorn :. omans comrses an amno ac seuence as seorn an o onnee o or more anse:nnn.enn aen o cam, werene aeas one oe -. omans comrses an one or more anennn.enn aen o c amamno a,c w seereunencee a as seeasor onen o ane o one o s:-. omans comrses an amno ac seuence as seorn an onnee o or more anse:n-nn..omeannsn aen o cam, werene aeas one oe one or more anennn.en cnom aresnes o an amno ac seuence as seorn an one o s:-. omans comrses a cam, werene aeas one oe one or more anennn .enn aen on a anmn oone ac o c seauence as seorn an one o s:-. anennnomans comrses amso, werene aeas one oe one or more ac seuence seorn n am:no a,c seuence a:ea,s enca:oe amno ::, :, :, :, :,, :,, :, :, :, :, :, ::,, :, :, :, :, :, ::,, :, :, :. :, :, or . aneennnnn aenom oa anns co omner ose csa anm asmnoo ac, w seeureennce ae aeaseas onee oncae oone or more ac seuence seorn :, :, e amno ::, :, :, :, ::,, :,, :, :, :, :, :, ::, :, :, :, :, :,, ::, :, :, :. , :, :, or . onen or mnor aee ann coemnrnsnn one or more anennnomans, weren aeas one oe an comrses omansnsorooas ce surace anen- a. a seeuaev: nce c saen coormnemenaree:rmn, ane reavon ca avne amno ac reon avn n comemenareermnn e e amno ac seuence seorn : an a seauven ccea sen coormenmenare:erm,nn reon avne amno ac. a seeuaevnce c saen coormnemenaree:rmnn reon avne amno ac reon avne amno ac, a seeauvenc ce saeno cormnemenare:ermnn : or : an aeav can comemenaree , avne amno ac seuence rmnn reon c. aeav can comemenar seorn :, seuen eermnn reon avne amno ac reonce seornavne amn:o ac, a seeauven can comemenareermnn eav can comemena ce seorn : an a seue reermnn reon avne amno ac . aeavnce c saeno cromnemen :, seu areermnn reon avne amno ac reoennce seornavne amn:o ac, a seeauve can comemenareermnn : an aeav can com nce seorn : orn avne amno a emenareermnn reon e. a avnce a smenuence seorn :, avne a o ac seuence as seorn :, a e amno acmn soe acuen scee ause snece aosr senorn :: anor a avn . aavne aamvnno ace a smeuneon acce as s seeueonce as seorn :, a e amno ac seuence rn : anor a avn . a avne am anso se acor seunen : avne amno ac seu ce as seorn :, a e amno ence as seorn : anor a avn . a acavn seueen acme as seorn : avne no ac seuence as seorn :, a e amno a acmn soe acuen scee ause snece aosr senorn :: anor a avn. aavne aamvnno ace a smeuneon acce a seuence as seorn :, a e amno ac s s seorn : anor a avn. a avneueen acme anso seorn : avne amno ac seuen acce as s seeueonrce ans seorn: ano:, a e amno ac seuence as seo r a avn . a avne amno acr seunence as : avne amno ac seuen seorn :, a e amno a ce as seorn : anor a avn. a cavn seueen acme as seorn : avn no ac seuence as seorn :, a e amnoe a acmn soe acuen scee ause snce as seorn : anor a avn m. a avne amnoe acor seunenc : avne amno ac seu e as seorn :, a e am ence as seorn : anor a avn n. a no acav seuence as seorn : avne amnno ace a smeuneon acce as s seeueonrce as seorn :, a e amno ac seuenc n : anor a avn o. a avne ame anso se acor sen : avne amno ac seuence as seueonrce ans seorn: anor a:, aavn . ae amno ac avne aamvnn seue o acen ac sme a euns eo se n accor e as s seunence as seo:rn :, a e amno ac seue eorn : anor a avn . a avnen acme anso se acorn : avne amn seuence as seorn :, a e amno ac soe acuen scee ause snece aosr senorn :: anor a avnr. aavne aamvnno ace a smeuneon acce seuence as seorn :, a e amno ac s as seorn : anor a avn s. a avneueen acme ans seorn : avne amno ac seueon acce as s seeueonrce ans seorn: an :, a e amno ac seuence as se or a avn. a avne amno acor seunence a : avne amno ac seue s seorn :, a e amno nce as seorn : anor a avn u. a acavn seueence as seorn : a amno ac seuence as seorn :, a ev anmnoe a acmn soe acuen scee ausence as seorn : anor a avn v. a avne amno se acor seunen : avne amno ac se ce as seorn :, a e a uence as seorn : anor a avn w. amno aca seuence as seorn : avne amvnno ace a smeuneon acce as s seeueonce as seorn :, a e amno ac seuenc rn : anor a avn x. a avne ame anso se acor sen : avne amno ac seuence as seueonrce ans seorn: anor a:, aavn . ae amno ac avne aamvnn seue o acen ac sme a euns eo se n accor e as s seunence as seo:rn :, a e amno ac seue eorn : anor a avn z. a avnen acme anso se acorn : avne amn seuence as seorn :, a e amno ac soe acuen scee ause snece aosr senorn :: anor a avnaa. aavne aamvnno ace a smeuneon acc seuence as seorn :, a e amno ac e as seorn : anor a avn . a avn seueen acme ans seorn : avne amno ac seueon acce as s seeueonrce ans seorn: an :, a e amno ac seuence as se or a avn cc. a avne amno acor seunenc : avne amno ac se e as seorn :, a e am uence as seorn : anor a avn . a no ac a avn seueen acme anso se acor seunence as seo:rn :, a ev anmnoe a acmn soe acuen scee auence as seorn : anor a avn ee. a avne a smeuns eo se n accor e as s seeun : avne amno ac eonrce ans seorn: anor a:, aavn . ae amno ac seuence as seorn : avne aamvnno ace a smeuneon acce as s seeuence as seorn :, a e amno ac seuen orn : anor a avn . a avne acme anso se acor sen : avne amno ac seuence as seueonrce ans seorn: anor a:, aavn . ae amno ac avne aamvnn seue o acen ac sme a euns eo se n accor e as s seunence as seo:rn :, a e amno ac seue eorn : anor a avn . a avnen acme anso se acor sn : avne amno euence as seorn :, a e amno ac se acuen scee ause snece aosr senorn :,: anor a avn. aav avne amno ac seuence as seorn :, a ene amno ac seuence as seorn : anor a avn.omeanns cn am om an reo sn ac es o s a ce eaau vmence ca, a n ws s coee mreonr emeen n aarease oene o:e, one or more anennn amno ac seuence seorn :, rmnn reon avne reon avne am aeav can comemenareermnn can comeme no ac seuence seorn : an aeav orn nar:e anerm ann anmn roe acon seuence aeaavsne aemnncoa aco seeuence se seeuennce sne ao amno ac. ren on a cna omne o, werene: aea,s one oe: one o orr m :. omans comrses aeav can com ore anennn amno ac seuenc emenareermnn reon avne re e seorn :, aeav can comemenareermnn con avne amno ac seuence seorn : an aeav orann comemenar:e anerm ann anmn roe acon seuence aeavne amno ac seuence se seuence seorn an one o as encaoe amno ac.enn aen o cam, werene: aea osr one oe:. omans comrses aeav one or more anennn amno ac can comemenareermnn reon avne reon seuencea svenoren amno ac se:uen,c ae seeavo crann comemena:r aeermnn can comemenareermnn reon avne n aeav orn : an an amno ac seu amno ac seuence se seuence seorn ence aeas encaoe amno ac.enn aen o c anam one o or, weren:e a or :. omans com eas one oe one or more anennn.enn arenses ou cmanzeramewor reons. omans comrsesumaamnr oamrew,o wre rreenonse. aeas one oe one or more anennn. aneennn aen o an one o camso, werene aeas one oe one or more comrsnnneomans comrseseumanzeeav can varae reonacone : amno ac seuence seorn :, : or. aneennn. n aneno oma anns o cnoem or cseasmseuoman,z weereeanve aeas one oe one or more comrsne can varae reonacone : amno ac seuence seorn :, : or. aneen.n aen o an one oe camso, werene aeas one oe one or more comrnsnnnomans comrseseumanzeeav can varae reonacone : e amno ac seuence seorn :, :, :,, ::, :, :, :, :, :,, ::,, :, :, :,, :n,rom oneo:ve am, :, no ac su: :, : or comrs su,ons, : or eeon aons anor. aneennsner n aeo nen. o om aanns o cnoem or csaesmsumoanz,e wereeavn ce aanea vsar oane oe one or more comrsne amno ac s e reonacone :, :,euence seo:rn, ::,, ::,, ::,, :, :, :, :, :, ::,, :, :, :, o:ve am ,no ac sus:uo, : ns, aon:, an ::, or comr:sn,rom one.enn aen o an s anoreeonsereo. comrses arame one oerecen cams, wereneeav can varae reon :,wor reon:, comrs:n,e seuence s:eo,rn :, :, :, :, : or ::.,. one onr mnor ae aenn ceonmrnsnn onoem oarn msoren asnoernononas coema sunrs,a weren aeas one oe comrsese amn ce anen- an : o ac seuence seorn :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :,, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, :, ::, :, :, :, :, .enn aeenn o o c:, :, :, :,.enn a anam, or one, o weerenrecee: nn. cnam asen comrses amerzaonoman. more anennnomanss aea , werene aeas one oe one or.enn aen o an one oev can varae reon o a sneoman ano. omans oenn aen areeavre cceann va craames, re woenre on onee a or moere an sneneonmann. an roeo m anes camn. aen o cam or, werene one or moreeav can varae reons are.woe annne aen o or an on.e oerecen cams, werenenn aen comrses.enennn anomans or more. monosecc.en o an one oerecen cams, werenenn aens..eennnn a aeenn o o a ann o onnee o camso, werenenn aenssecc..enn aen o cam o or ca,m wsereon,e wnerenn aeennn aens musecc. nnomananso anor one or more anen comnrnses oone or more anen -. mananso.oeenn aen o an one o camso, werenenn aen comrseswo ason, ae cea onnse an or weren eacoee can comrsesn a-o-ermna merzaonoma more anennnomans, oona aner an c a.oeenne c aaennn s a o. n a wne orenen o eac caomseoe c, werenenn aen comrseswo an amno ac seuence oorm an comrsesn a-o-ermnaason -ua:- --- - eren ms,, or anneerareab m c dneren ns,, or anneerreaeerran er anre een nn m an na, n a ndo,r an e m eea n aco ns re s s arem ns aeu nnasn ae enou n ans nennonmannoman w,e arne ann aeenas onne oe oman seu are orn ane anene n eren or ennnrenseno omra ansen an comrses an amno ac ee errenc ene nb, rec, eraecsenns aeemneernza comrses one or moreners an .enn aen o cam, oro,n woemreann oman o emerzaonoman comrses a.enn an a aneno o or aoronereo. an ano or aoro cnamereo, w.erenemerzaonoman comrses a oman o.umeannn, auemna on cam,um oarn, w oerrenume oman anor omansrom a.enn an a amenno o ac an se onueen oce c aameass,an eav can. comrses orenoca,o weer aemnnoe acm seeruzeancoen seomoarn.nenn a:en o or :. easwo anenn ann onoem oanse anrec ween cams, werenenn aen comrses a enca rene aeaswo anennnomans are.ce orn o cnr or aoneenren a o. s an ca oanee o oenrenceon an cca rmecse, wore ore mnoneocnn aen comrses a.enn aen o an oerecen cams, werene one ores m aonreo arn maecnroaes. omans arenane nn. sneenomna an aenn om o a.n one oerecen cams, werenenn aen comrses a.enn aen o an. one oerecen cams, werenenn aens a sne.om .ean enn an nn a ao eenn. o o a ann oerecen cams, werenenn aens nae. aeraeuc moe. oerecen cams, werenenn aens conuae w. aenn aen o an oerecen cams, werenenn aens conuae w.oeeecnane m aoene o. an one oerecen cams, werene one or more anennn.meanns onrenn aen seccanouman . oman ano aen co om arnsn onew ooeenrceacen cams, werenenn aens a sne c eav can varae reons orwoencaeav.an oeasr.mreacceeunca c caommso asno an coamrmarcseuncae anccena aeen ca orrr sern.eoman ano o an. an nucec ac or se o nucec acs encon enn aen or sneoman ano o. ve ocore comrecresnn cams. . ce exressn ee nucec ac o cam . . ce comrsn e nuncenc aen or sneoman ano o an o erecen cams.. comrsn enn a acen o or c sanmeo omrane a vnecoor o o ca anm o. . comrsn e nucec ac o cam ,e vecor o cam oree cerec oen cams. . cam or.o mmeano an oroean o a ansor oneer o orseeaser ceocmernsn ca ammsn orse arnarmeacneunca a ceonm oro ssnone. come mresno oenn aen or sneoman ano o an one o erecen cams. or overex cam , werenesorer orseases assocae w exresson. canece mr,eunores c oso anc cn. ear,m meas, waceruenn caencesr,o srmear o cresuenase casnc cancer, so umor, e ea meoma,rosae cancer,reas cance er, non-sma ceun cancer, cancer, oasoma, cervca cancer, cro,orrecea ne caancveer,raesasrc ca cnancceer,r, re ocvaar caancer,ancreac cancer, somac cancer, urnar aer cancer, canc n cancer, ro cancer, orea an nec cancer. er o e uerus, esoeea cancer,oo

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