Syringe accessories

Abstract

Provided herein are syringe accessories and methods of use thereof with syringes for injection. The syringe accessories described herein may include a single monolithic housing comprising a tubular portion configured to receive a barrel of a syringe, one or more flanges at a proximal end of the tubular portion, and a base portion at a distal end of the tubular portion. The base portion may extend outward in at least one direction from an outer surface of the tubular portion toward an end of the base portion that is configured to provide a stable contact surface on an injection site. The one or more flanges of the housing may be larger than that of the syringe inserted to the housing. The housing may be configured to limit protrusion of a needle when the syringe barrel is received in the tubular portion of the housing.

Description

SYRINGE ACCESSORIESCROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims priority to and the benefit of U.S. Provisional Patent Application No. 63 / 518,097, the contents of which are incorporated herein in its entirety.FIELD

[0002] This disclosure relates generally to syringe accessories, and more specifically to syringe accessories that comprise single monolithic bodies and methods of using the syringe accessories with a syringe for injection.BACKGROUND

[0003] Various devices and methods are used to deliver a drug, such as an active pharmaceutical ingredient (API), to patients. For example, APIs can be injected using a syringe or autoinjector, ingested / consumed orally, or inhaled. Syringes can be used to deliver APIs in fluid form directly to the intended injection site (e.g., the blood stream) with maximum efficacy. Moreover, different APIs require injection at different depths through the skin to achieve maximum efficiency, such as an intravenous, intramuscular, subcutaneous, intradermal, etc. In some instances, different APIs may also require injection at a specific angle, for example, to avoid intramuscular injection if the intended site is a subcutaneous injection. Several types of syringes of various complexities exist. For example, syringes can be pre-filled, can include needle safety features, can vary in number of components (e.g., a barrel, plunger rod, needle, and optionally a plunger stopper), etc. In clinical studies, conventional manual syringes are typically used in to manually inject drugs.SUMMARY

[0004] Described herein are syringe accessories and methods of use of the syringe accessories with syringes for injection. The syringe accessories can attach to a syringe or be embodied in a syringe device itself to limit the injection depth of the syringe, provide stable contact with the skin surface, and improve ergonomics of syringe use. The syringe accessory may comprise a single monolithic housing that comprises a tubular portion, one or more flanges at a proximal end of the tubular portion, and a base portion at the distal portion. When a syringe is inserted into the syringe accessories described herein, protrusion of the needle from the base of the syringe accessory canbe limited to a desired injection depth. The base portion may provide a stable contact angle for injection on a user’s skin. Use of syringes may be improved and simplified due to the larger flanges provided at the end of the syringe accessories described herein.

[0005] As mentioned above, most commonly (e.g., at least in clinical studies), low-cost, conventional manual syringes are used to manually inject the APIs. Although simple in design and function, conventional syringes are attributed with a large potential for user error. For example, without extensive experience, it can be difficult using conventional syringes to ascertain the appropriate injection depth and / or injection angle for a specific type of injection. Improper injection necessitates repeat attempts to achieve the correct injection, which can cause patient injury or pain, contribute to material waste (e.g., waste of not only the syringe, but also the syringe contents (API) and syringe packaging), and increase patient care times. Furthermore, variations in injection angle, injection depth, and / or skin contact effects during use of syringes in clinical trials can lead to inaccurate results. Finally, conventional manual syringes may have minimal ergonomic features which in turns makes it challenging for users to easily use the syringe.

[0006] Existing syringes and / or syringe add-ons (e.g., accessories) have attempted to address one or more of these issues, however, aside from falling short in comprehensively addressing each of the aforementioned pitfalls of syringes, often comprise multiple components and are only compatible with one or a limited number of syringe types. Therefore, a gap remains in the field for a device such as a syringe or syringe accessory that solves all of these issues and more in a succinct, simple manner.

[0007] The syringe accessories provided herein can be used to mitigate the difficulties associated with syringes, whether it be the conventional manual syringes described herein, more complex variations thereof, or syringe add-ons that have attempted to address one or more of the aforementioned issues. The syringe accessories described herein can comprise a single monolithic housing that a syringe can easily be inserted into for injection. The single monolithic housing can comprise one or more flanges at a distal end of a tubular portion of the housing that improve ergonomics and ease of use for the user. The housing can furthermore comprise a base portion that extends outward from the tubular portion of the housing in at least one direction to provide a stable contact surface on an injection site. Finally, when inserted into the single monolithic housing, protrusion of the needle from syringe can be limited, thus providing a consistent injection depth.

[0008] In some embodiments, a syringe accessory is provided, comprising: a single monolithic housing comprising: a tubular portion configured to receive a barrel of a syringe; one or more flanges at a proximal end of the tubular portion; and a base portion at a distal end of the tubular portion that extends outward in at least one direction from an outer surface of the tubular portion toward an end of the base portion that is configured to provide a stable contact surface on an injection site, wherein the single monolithic housing is configured to limit protrusion of a needle of a syringe when the barrel of the syringe is received in the tubular portion.

[0009] In some embodiments, a method of assembling a syringe and a syringe accessory is provided, comprising: inserting a barrel of the syringe into a proximal end of a tubular portion of the syringe accessory; and advancing the barrel toward a distal end of the tubular portion until one or more flanges of the syringe clips on one or more latches on an inner surface of the syringe accessory, wherein the syringe accessory comprises a single monolithic housing comprising the tubular portion, one or more flanges at the proximal end of the tubular portion, and a base portion at the distal end of the tubular portion that extends outward in at least one direction from an outer surface of the tubular portion toward an end of the base portion to provide a stable contact surface on an injection site.

[0010] In some embodiments, a method of injecting an active pharmaceutical ingredient (API) contained in a syringe is provided, comprising: inserting a needle of the syringe into an injection site, the syringe disposed in a single monolithic housing comprising: a tubular portion that receives a barrel of the syringe; one or more flanges at a proximal end of the tubular portion; and a base portion at a distal end of the tubular portion that extends outward in at least one direction from an outer surface of the tubular portion toward an end of the base portion to provide a stable contact surface on the injection site; and injecting the API at the injection site at a depth of the needle limited by the single monolithic housing.

[0011] In some embodiments, a syringe, comprising: a plunger comprising a plunger stopper at a distal end of the plunger and a plunger rod extending from the plunger stopper; and a single monolithic housing, comprising: a barrel configured to receive the plunger rod; one or more flanges at a proximal end of the barrel; and a base portion at a distal end of the barrel that extends outward in at least one direction from an outer surface of the barrel toward an end of the base portion that is configured to provide a stable contact surface on an injection site, wherein the singlemonolithic housing is configured to limit protrusion of a needle when the needle is coupled to the distal end of the barrel.

[0012] In some embodiments, a method of injecting an active pharmaceutical ingredient (API) contained in a syringe is provided, comprising: inserting a needle of the syringe into an injection site, the syringe comprising: a plunger comprising a plunger stopper at a distal end of the plunger and a plunger rod extending from the plunger stopper; and a single monolithic housing, comprising: a barrel that receives the plunger rod; one or more flanges at a proximal end of the barrel; and a base portion at a distal end of the barrel that extends outward in at least one direction from an outer surface of the barrel toward an end of the base portion that provides a stable contact surface on the injection site; and injecting the API at the injection site at a depth of the needle limited by the single monolithic housing.BRIEF DESCRIPTION OF THE FIGURES

[0013] Various aspects of the disclosed systems and methods are set forth with particularity in the appended claims. A better understanding of the features and advantages of the disclosed systems and methods will be obtained by reference to the detailed description of illustrative embodiments and the accompanying drawings.

[0014] FIG. 1 A illustrates a perspective view of a first exemplary syringe accessory, in accordance with some embodiments.

[0015] FIG. IB illustrates a front view of the first exemplary syringe accessory, in accordance with some embodiments.

[0016] FIG. 1C illustrates a cross-sectional perspective view of the first exemplary syringe accessory, in accordance with some embodiments.

[0017] FIG. ID illustrates a side view of the first exemplary syringe accessory, in accordance with some embodiments.

[0018] FIG. IE illustrates a bottom view of the first exemplary syringe accessory, in accordance with some embodiments.

[0019] FIG. IF illustrates a top view of the first exemplary syringe accessory, in accordance with some embodiments.

[0020] FIG. 1G illustrates a partial perspective view of a first exemplary syringe accessory, in accordance with some embodiments.

[0021] FIG. 2A illustrates a perspective view of a second exemplary syringe accessory, in accordance with some embodiments.

[0022] FIG. 2B illustrates a front view of the second exemplary syringe accessory, in accordance with some embodiments.

[0023] FIG. 2C illustrates a cross-sectional perspective view of the second exemplary syringe accessory, in accordance with some embodiments.

[0024] FIG. 2D illustrates a side view of the second exemplary syringe accessory, in accordance with some embodiments.

[0025] FIG. 2E illustrates a bottom view of the second exemplary syringe accessory, in accordance with some embodiments.

[0026] FIG. 2F illustrates a top view of the second exemplary syringe accessory, in accordance with some embodiments.

[0027] FIG. 2G illustrates a partial perspective view of a second exemplary syringe accessory, in accordance with some embodiments.

[0028] FIG. 3A illustrates a perspective view of the first exemplary syringe accessory and syringe assembly, in accordance with some embodiments.

[0029] FIG. 3B illustrates a perspective view of the second exemplary syringe accessory and syringe assembly, in accordance with some embodiments.

[0030] FIG. 4A illustrates a perspective view of a first exemplary syringe accessory and syringe assembly relative to an injection site, in accordance with some embodiments.

[0031] FIG. 4B illustrates a perspective view of a second exemplary syringe accessory and syringe assembly relative to an injection site, in accordance with some embodiments.

[0032] FIG. 5A illustrates a perspective view of an exemplary syringe accessory including a locking member disposed at the proximal end of the tubular portion within the one or more flanges of the syringe accessory to retain a syringe within the syringe accessory, in accordance with some embodiments.

[0033] FIG. 5B illustrates a perspective view of the syringe accessory of FIG. 5A having a syringe disposed therein, in accordance with some embodiments.

[0034] FIG. 5C illustrates a top view of the syringe accessory of FIGS. 5A-5B, in accordance with some embodiments.

[0035] FIG. 5D illustrates a partial side view of the syringe accessory of FIGS. 5A-5C, in accordance with some embodiments.

[0036] FIG. 6A illustrates a perspective view of an exemplary syringe accessory including an opening extending the length of the tubular portion of the syringe accessory and one or more retaining portions positioned relative to the opening to retain a syringe within the syringe accessory, in accordance with some embodiments.

[0037] FIG. 6B illustrates a perspective view of the syringe accessory of FIG. 6A having a syringe disposed therein, in accordance with some embodiments.

[0038] FIG. 7A illustrates a perspective view of an exemplary syringe accessory including a door extending a length of the tubular portion of the syringe to receive and remove a syringe from within the syringe accessory, in accordance with some embodiments.

[0039] FIG. 7B illustrates a perspective view of the exemplary syringe accessory of FIG. 7A having a syringe disposed therein, in accordance with some embodiments.

[0040] FIG. 8A illustrates a perspective view of an exemplary syringe accessory including an opening extending a length of the tubular portion and the base portion of the syringe accessory and one or more retaining portions disposed relative to the opening to retain a syringe within the syringe accessory, in accordance with some embodiments.

[0041] FIG. 8B illustrates a perspective view of the exemplary syringe accessory of FIG. 8A having a syringe disposed therein, in accordance with some embodiments.

[0042] FIG. 8C illustrates a perspective view of the base portion of the exemplary syringe accessory of FIG. 8A, in accordance with some embodiments.

[0043] FIG. 8D illustrates a cross-sectional view of the base portion of FIG. 8C, in accordance with some embodiments.

[0044] FIG. 9A illustrates a perspective view of an exemplary syringe accessory including an opening extending a length of the tubular portion and the base portion of the syringe accessory and a door extending a portion of a length of the opening to retain a syringe within the syringe accessory, in accordance with some embodiments.

[0045] FIG. 9B illustrates a perspective view of the syringe accessory of FIG. 9A having a syringe disposed therein, in accordance with some embodiments.

[0046] FIG. 9C illustrates a perspective view of the base portion of the exemplary syringe accessory of FIG. 9A, in accordance with some embodiments.

[0047] FIG. 9D illustrates a cross-sectional view of the base portion of FIG. 9C, in accordance with some embodiments.

[0048] FIG. 10A illustrates a perspective view of a base portion of an exemplary syringe accessory that includes a convex surface for contacting the surface of a patient’s skin, in accordance with some embodiments.

[0049] FIG. 10B illustrates a cross-sectional view of the base portion of FIG. 10A, in accordance with some embodiments.

[0050] FIG. 11 A illustrates a perspective view of a base portion of an exemplary syringe accessory that includes a convex surface for contacting the surface of a patient’s skin, the base portion including one or more openings separated by one or more ribs along the convex surface of the base portion, in accordance with some embodiments.

[0051] FIG. 1 IB illustrates a cross-sectional view of the base portion of FIG. 11A, in accordance with some embodiments.

[0052] FIG. 12A illustrates a perspective view of a base portion of an exemplary syringe accessory that includes an outer portion and an inner portion extending distal to the outer portion, in accordance with some embodiments.

[0053] FIG. 12B illustrates a cross-sectional view of the base portion of FIG. 12A, in accordance with some embodiments.

[0054] FIG. 13 A illustrates a perspective view of a base portion of an exemplary syringe accessory that includes an outer portion and an inner portion that are aligned at the distal end of the base portion, in accordance with some embodiments.

[0055] FIG. 13B illustrates a cross-sectional view of the base portion of FIG. 13 A, in accordance with some embodiments.

[0056] FIG. 14A illustrates a perspective view of a base portion of an exemplary syringe accessory that includes an outer portion extending outward in at least one direction, in accordance with some embodiments.

[0057] FIG. 14B illustrates a cross-sectional view of the base portion of FIG. 14A, in accordance with some embodiments.

[0058] FIG. 15 A illustrates a perspective view of a base portion of an exemplary syringe accessory that includes an outer portion extending inward in at least one direction, in accordance with some embodiments.

[0059] FIG. 15B illustrates a cross-sectional view of the base portion of FIG. 15 A, in accordance with some embodiments.

[0060] FIG. 16 illustrates a perspective view of a portion of a tubular portion of a syringe accessory that includes a finger pad disposed along a length of the tubular portion, in accordance with some embodiments.DETAILED DESCRIPTION

[0061] Syringe accessories and methods of using the syringe accessories with syringes for injection are described herein. The syringe accessories attach to a syringe and can provide several advantages to a user of the syringe. The advantages may include: 1) limiting the injection depth of the needle, 2) providing a stable contact with a user’s skin, and 3) improving the user’s grasp of the syringe. The syringe accessories may include a housing that includes a tubular portion, one or more flanges at a proximal end of the tubular portion, and a base portion at a distal end of the tubular portion. The housing may be formed from a single monolithic piece of material. The housing may limit protrusion of a needle of a syringe extending from the base portion of the housing to only the amount necessary to provide the desired injection depth. Thus, when properly inserted in the tubular portion of the monolithic housing, a syringe may achieve a desired injection depth at an injection site. The base portion of the single monolithic housing may also provide a stable injection angle at an injection site. For example, the base portion may extend outward in at least one direction from an outer surface of the tubular portion of the housing toward an end of the base portion that is configured to contact a skin surface at the injection site, which can provide a stable injection angle (e.g., an injection angle of about 90° relative to the skin surface).

[0062] The syringe accessories described herein may be adaptable for use with syringes of various complexities and for various intended uses. For example, the syringe accessories described herein may be used with conventional manual syringes, which are commonly used in clinical trials of drugs at least due to their accessibility and affordability. Moreover, the syringe accessories described herein may be used with needles that inject intravenous, intramuscular, subcutaneous, and / or intradermal, based on intended use. Thus, the syringe accessories described herein may mitigate one or more shortcomings with syringes to improve outcomes using syringes as well as user experience with said syringes. In the scenario the syringe accessories described hereinaccommodate syringes used in clinical studies, the syringe accessories may mitigate any potential variations in results due at least to inconsistent use of the syringe.

[0063] The syringe accessories described herein may provide a consistent desired injection depth and injection angle and may improve device ergonomics in a single, simple housing. The syringe accessories may be used with syringes and / or needles that comprise needle safety features and, in some instances, may additionally or alternatively comprise needle safety features themselves. In some instances, the syringe accessories described herein may be reasonably embodied in a syringe and / or needle itself, which is understood to be within the scope of the disclosure provided herein. Achieving each of the aforementioned features in a single, simple monolithic device is a challenge that existing syringes and / or syringe accessories have failed to adequately accomplish.

[0064] As used herein, a syringe may include a hypodermic syringe, pre-filled syringe, glass syringe, plastic syringe, etc. The syringes may comprise a barrel, plunger rod, and in some embodiments, a plunger stopper. The syringes may be configured to attach to various needles, the scope of which is not intended to be limited by the disclosure provided herein. In some embodiments, the syringes, needles, and / or syringe accessories described herein may comprise one or more needle safety features, such as a retractable needle feature, a pivoting needle cap, etc. One of ordinary skill in the art would be able to reasonably apply the syringe accessories disclosed herein to various injection devices, including various syringes, injectors, needles, etc.

[0065] As used herein, an active pharmaceutical ingredient (API) may include a pharmaceutical product, medication, antibiotic, vaccine, drug, etc. Example APIs may include reconstituted antibiotics, injections, and other large-molecule drugs in liquid form (e.g., Nipocalimab). The list of APIs provided above is not intended to be exhaustive and may extend to any pharmaceutical, drug, medication, antibiotic, vaccine, etc. not explicitly stated herein.

[0066] As used herein, the proximal and distal portions or ends of the housing (or tubular portion of the housing) are understood to be defined with respect to the user of the syringe. For example, the proximal portion or end of the housing is the portion / end closest to the user’s hand that is holding the syringe. Conversely, the distal portion or end of the housing (or tubular portion of the housing) is the portion / end farthest from the user’s hand that is holding the syringe. In other words, the distal portion / end would be the end of the syringe understood to be attached to (or configured to be attached to) a needle that would then be injected into a patient.

[0067] In some embodiments, the syringe accessories described herein may be provided pre-attached to a syringe. That is, the syringe may be provided as housed in a syringe accessory described herein. In some embodiments, a user may be required to insert the syringe into the syringe accessory before injection with the syringe. The syringe accessory and syringe may be fixedly attached such that, once assembled, the syringe (e.g., syringe barrel) and the housing of the syringe accessory do not translate relative to one another.

[0068] In some embodiments, the syringe accessories may be single -use and disposable. In some embodiments, the syringe accessories may be sterilizable and thus reusable. In some embodiments, a syringe may be pre-filled with an API. Alternatively, a user may be required to fill the syringe with an API prior to use of the syringe and associated syringe accessory.

[0069] As will be described in greater detail below, it is to be understood that features of the syringe accessories described herein may be incorporated into a syringe device. That is, rather than providing a separate syringe and syringe accessory, a single device comprising conventional syringe features and features of the syringe accessories described herein may be provided.

[0070] The syringe accessories provided herein will now be described first as standalone devices with reference to two exemplary embodiments, followed by assemblies comprising the syringe accessories and syringes and methods of using the syringe with the syringe accessory and methods of assembling the syringe and syringe accessory. Then, an example syringe device comprising syringe accessory features described herein will be described, as well as methods of use thereof.Syringe Accessories

[0071] FIGS. 1A-1G illustrate various views of a syringe accessory in accordance with a first embodiment, the syringe accessory comprising a single monolithic housing 100. The single monolithic housing 100 (hereinafter referred to as housing 100 for simplicity) may comprise a tubular portion 102 configured to receive a barrel of a syringe, one or more flanges 104 at proximal end of tubular portion 102, and a base portion 106 at a distal end of tubular portion 102. As shown, base portion 106 may extend outward in at least one direction from an outer surface of tubular portion 102 toward an end of base portion 106.

[0072] In some embodiments, tubular portion 102 may be configured to receive a syringe barrel, such as a barrel with a volume capacity between 0.1 mL and 70 mL. For example, tubular portion 102 may be configured to receive a syringe barrel with a volume capacity of 3 mL or 5 mL, each of which are shown in FIGS. 3A and 3B, respectively. In some embodiments, the tubular portion102 may be configured to receive a barrel of a syringe with a 0.1 mL, 0.25 mL, 0.3 mL, 0.5 mL, 1 mL, 2.5 mL, 3 mL, 5 mL, 10 mL, 20 mL, 30 mL, 45 mL, 50 mL, 60 mL, 70 mL, or other volume capacity therebetween and not explicitly stated.

[0073] In some embodiments, the shape of housing 100 (e.g., tubular portion 102) may account for the shape and / or size of the syringe that the housing is configured to receive. For example, at least the internal structure of the tubular portion 102 may be sized to accommodate the syringe barrel. In other words, dimensions (e.g., length, width, etc.) of at least the internal structure of tubular portion 102 may be dependent at least on the syringe that housing 100 is configured to receive. The external structure of tubular portion 102 may mimic this structure, as shown in FIGS. 1A-1G. For example, housing 100 (e.g., tubular portion 102) may comprise a uniform walled structure along the length of tubular portion 102. The wall thickness of housing 100, and more specifically at least of tubular portion 102, may be about 0.75, 1, 1.25, 1.5, 1.75, 2, 2.25, 2.5, 2.75, or 3 mm, or other volume capacity therebetween and not explicitly stated.

[0074] Alternatively, in some embodiments, the external structure of housing 100 may comprise various shapes, for example, to improve ergonomics and / or allow visualization of the syringe (e.g., visualizations of the API in the syringe and / or markings on the syringe). For example, the external structure of at least tubular portion 102 of housing 100 may comprise a monolithic rectangular, circular, ovular, etc. body formed around an internal structure of tubular portion 102 that comprises a hollow receptacle configured to receive the syringe.

[0075] As shown, tubular portion 102 may comprise a constriction 108. The constriction 108 may approximately distinguish a proximal portion of tubular portion 102 from a distal portion of tubular portion 102. The constriction may in some embodiments reside substantially solely in the internal structure of tubular portion 102. When inserting the syringe into housing 100, the syringe barrel may be advanced through the tubular portion 102 until an end of the syringe barrel meets the constriction 108 (e.g., the end of the proximal portion of tubular portion 102). Therefore, constriction 108 may limit advancement of the syringe through housing 100, such that substantially all of the syringe barrel is disposed proximal to constriction 108 (e.g., in the proximal portion of tubular portion 102), and substantially all of the syringe needle is disposed distal to constriction 108 (e.g., in the distal portion of tubular portion 102). Moreover, constriction 108 may limit the protrusion of the needle beyond the distal portion of tubular portion 102 (and base portion 106). The distal portion of tubular portion 102 may shield at least a portion of the needle of the syringewhen the syringe barrel is inserted into the proximal portion of tubular portion 102. Alternatively or additionally, tubular portion 102 (e.g., the distal portion of tubular portion 102) may be configured to receive a syringe needle that is shielded (e.g., by a removable cap, as illustrated at least in FIGS. 3A-3B).

[0076] As described herein, base portion 106 may extend outward from an outer surface of tubular portion 102 toward the end of base portion 106. In some embodiments, base portion 106 may extend outward from an outer surface of tubular portion 102 in 1, 2, 3, 4, 5, 6, or more directions. FIGS. 1A-1G illustrate a base portion 106 comprising a flared or conical shape. In other words, base portion 106 as shown in FIGS. 1A-1G can extend outward uniformly from the outer surface of tubular portion 102. In some embodiments, base portion 106 may additionally or alternatively extend outward vertically (e.g., along a longitudinal axis concentric with tubular portion 102) from an end of tubular portion 102 toward the end of base portion 106. FIG. 1G illustrates an embodiment in which base portion 106 comprises an outer portion 114 that extends outward circumferentially from an outer surface of tubular portion 102 toward an end of base portion 106 and an inner portion 116 that extends outward vertically from an end of tubular portion 102 toward the end of base portion 106. Each of the outer portion 114 and inner portion 116 of base portion 106 may extend to meet a plane (e.g., an X-Z plane) substantially orthogonal to the longitudinal axis of housing 100. In some embodiments, one of the outer portion 114 and inner portion 116 of base portion 106 may not fully extend to said X-Z plane, such that only one of the outer portion 114 or inner portion 116 may contact the injection site during use of the syringe accessory with a syringe. For example, outer portion 114 may be configured to contact the injection site, and inner portion 116 may not. In this instance, inner portion 116 may extend from a distal end of base portion 106 about 20%, 25%, 30%, 40%, 50%, 60%, 70%, 75%, 80%, 90%, or 95% of the distance that outer portion 114 extends along the illustrated Y-axis from the distal end of base portion 106. In some embodiments, the portion of base portion 106 between outer portion 114 and 116 may be hollow (e.g., as illustrated at least in FIG. 1G), partially solid, or solid.

[0077] In some embodiments, base portion 106 may additionally or alternatively comprise one or more “legs” that individually extend at an angle from the outer surface of tubular portion 102 toward an end of base portion 106 to provide a stable contact surface on the injection site. For example, base portion 106 may comprise two legs that extend in opposite directions (e.g., in a direction along the X-axis or Z-axis) from tubular portion 102, three legs that extend outward tocreate a tripod-like base, four legs (e.g., 2 legs in the X-direction and 2 legs in the Z-direction), etc. The one or more legs may extend at an angle from the outer surface of tubular portion 102 toward the end of base portion 106, such as at a 20°, 30°, 45°, 60°, 70°, or another angle that is less than 90° relative to a central longitudinal axis of tubular portion 102.

[0078] The two-dimensional surface profile of base portion 106 (e.g., a profile in an X-Y plane, Y-Z plane, and / or any plane therebetween) may comprise an arc, line, or other type of curve. In some embodiments, the profile may comprise a first curve (e.g., a line, arc, etc.) with a first curvature, a second curve (e.g., a line, arc, etc.) with a second (different) curvature, etc. For example, FIGS. IB and ID illustrate the profile of base portion 106 in each of the X-Y and Y-Z planes, respectively, in which the profile comprises a continuous arc. However, the profile of base portion 106 may additionally or alternatively comprise a straight (or substantially straight) line, or combinations of arcs and lines.

[0079] As housing 100 is configured to receive a syringe (e.g., a barrel of a syringe) that extends through the tubular portion 102 and passed the end of base portion 106, it is understood that base portion 106 comprises an opening (e.g., a through-hole) that receives the syringe (e.g., a needle of a syringe, or in some embodiments, a shielded needle of the syringe). The opening in base portion 106 may be sized such that at least a needle or a shielded needle may be inserted through the base portion 106. The cross-section of the opening of base portion 106 may be circular, ovular, triangular, hexagonal, octagonal, square, rectangular, or another polygonal shape. In the instance base portion 106 comprises an outer section 114 and an inner section 116, the cross-section of the opening of base portion 106 may be different from the overall cross-section of base portion 106. For example, the overall cross-section of base portion 106 may be circular, ovular, triangular, hexagonal, octagonal, square, rectangular, or another polygonal shape. In some embodiments, the width of the cross-section (e.g., a width extending from a first point on an inner surface of the base portion 106 to a second point on an inner surface of the base portion 106 opposite the first point and within the same cross-sectional plane) may be between about 10 mm and 40 mm. For example, the width may be greater than or equal to 10 mm, 15 mm, 20 mm, 25 mm, or 30 mm. In some embodiments, the width may be less than or equal to 40 mm, 35 mm, 30 mm, 25 mm, 20 mm, or 15 mm. In the instance the cross-sectional shape of base portion 106 is circular, the width may be the diameter of the circular cross-section. In the instance base portion 106 comprises an outerportion 114 and an inner portion 116, respective widths of the inner and outer portions 114, 116 as defined herein may be within the aforementioned range of widths.

[0080] At least one cross-sectional dimension of base portion 106 may be larger than a cross-sectional dimension of tubular portion 102. For example, dimensions measured within an X-Z plane illustrated at least in FIGS. 1A and 1C may be larger in the base portion 106 than the tubular portion 102. For example, in the syringe accessory illustrated in FIGS. 1A-1G, a cross-sectional radial dimension extending from a central axis of the housing 100 (e.g., the Y-axis illustrated in FIGS. 1A-1D) toward an outer surface of housing 100 may be larger in the base portion 106 than in the tubular portion 102. In another example, a cross-sectional width measured from a first point on an outer surface to a second point on an outer surface opposite the first point (and within the same cross-sectional plane) may be larger in the base portion 106 than in the tubular portion 102. In the instance base portion 106 comprises an outer portion 114 and an inner portion 116, at least the aforementioned cross-sectional dimension of the outer portion 114 of base portion 106 may be larger in the base portion 106 than in tubular portion 102. In some embodiments, an aforementioned cross-sectional dimension of the inner portion 116 of the base portion 106 may be substantially the same as the cross-sectional dimension of tubular portion 102 (e.g., inner portion 116 may be an extension of a distal portion of tubular portion 102). In some embodiments, the cross-sectional dimension of inner portion 116 may be less than or greater than the cross-sectional dimension of tubular portion 102.

[0081] The aforementioned cross-sectional dimension(s) of the base portion 106 may increase (e.g., linearly, parabolically, etc.) as it extends outward from the outer surface of tubular portion 102 toward the end of base portion 106. Thus, the cross-sectional dimension of the end of base portion 106 may be the largest cross-sectional dimension (e.g., radius, diameter, width, etc.), at least of cross-sectional dimensions of tubular portion 102 and of base portion 106 of housing 100. For example, in comparison with a cross-sectional dimension of tubular portion 102, the cross-sectional dimension of the end of base portion 106 may be about 1.25, 1.5, 1.75, 2, 2.5, 3, or more times larger than the cross-sectional dimension of tubular portion 102.

[0082] The end of base portion 106 may comprise a surface substantially orthogonal to a central axis of housing 100 (e.g., the illustrated Y-axis) that is configured to provide a stable surface at the injection site. The shape of the surface may be dependent on the shape of the cross-section of base portion 106, described above. In some embodiments, the size (e.g., surface area) of the surfacemay be dependent on the size of the opening that extends through base portion 106, also described above. In the instance base portion 106 comprises an outer portion 114 and an inner portion 116, the size of the surface may be dependent on one or more characteristics of outer portion 114 and / or inner portion 116. For example, as explained herein, the bottom surface of base portion 106 may comprise a bottom surface of each of outer portion 114 and inner portion 116 of base portion 106. However, in some embodiments, the surface of base portion 106 may only comprise a surface of outer portion 114, or alternatively, of inner portion 116, such that one of outer portion 114 or inner portion 116 of base portion 106 is configured to contact the injection site.

[0083] In some embodiments, a width of the bottom surface of base portion 106 (e.g., extending between a first point on the bottom surface and a second point on the bottom surface opposite the first point) may be between 20 mm and 40 mm. For example, the width of the bottom surface of base portion 106 may be greater than or equal to 20 mm, 22 mm, 24 mm, 26 mm, 28 mm, or 30 mm. In some embodiments, the width of the bottom surface of base portion 106 may be less than or equal to 40 mm, 38 mm, 36 mm, 34 mm, 32 mm, or 30 mm. In the instance at least the bottom surface of base portion 106 comprises a circular shape, the width may be understood to be a diameter of the circular bottom surface.

[0084] As described herein, the single monolithic housing 100 may comprise one or more flanges 104 disposed at a proximal end of tubular portion 102. For example, FIGS. 1A-1F illustrate a pair of flanges 104 of housing 100. However, syringe accessories described herein are not intended to be limited to the two flanges as illustrated, and rather may include 1, 2, 3, 4, or more flanges, based at least on user preferences. The one or more flanges 104 may be larger than one or more flanges of a conventional manual syringe that can be housed in the syringe accessory. For example, the one or more flanges 104 may be about 1.25, 1.5, 1.75, 2, 2.5, 3 or more times larger than flanges of a syringe. Thus, the flanges 104 may improve the user’s grasp during use of the syringe and syringe accessory.

[0085] In some embodiments, housing 100 may comprise one or more latches extending from an inner surface of the housing toward a central longitudinal axis of tubular portion 102, examples of which are described in greater detail herein. The one or more flanges 104 of housing 100 may comprise one or more receiving portions configured to receive the syringe flanges when the syringe is inserted into housing 100. For example, at least FIGS. 1 A, 1C, and IF illustrate receiving portions 110 configured to receive one or more flanges of a syringe. The one or more receivingportions 110 may comprise one or more latches configured to latch, clip onto, or removably lock into place with the one or more syringe flanges when the one or more syringe flanges are inserted into receiving portions 110. For example, during assembly, a syringe may be advanced into tubular portion 102 of housing 100 until the syringe flanges are fully receiving by the receiving portions 110 and optionally removably locked into place with one or more latches disposed in the receiving portion(s) 110 of the one or more flanges 104. Thus, the receiving portions 110 may be configured to limit advancement of the syringe into tubular portion 102.

[0086] In some embodiments, housing 100 may comprise one or more latches at a proximal end of tubular portion 102. For example, tubular portion 102 may comprise one or more latches 105 configured to latch, clip onto, or removably lock into place with a portion of the syringe barrel when the syringe is inserted into the tubular portion 102. Latches 105 are illustrated with respect at least to FIGS. 1A and IF. Housing 100 may comprise said latches 105 in addition to or instead of latches in the receiving portions 110.

[0087] In some embodiments, tubular portion 102 may comprise one or more engagement surfaces on an inner surface of the tubular portion 102. For example, the one or more engagement surfaces may be disposed at a proximal end of tubular portion 102, at a distal end of tubular portion 102, and / or elsewhere along a length of tubular portion 102 between the proximal and distal ends. FIG. 1C illustrates exemplary engagement surfaces 112 within tubular portion 102. As shown, the one or more engagement surfaces 112 may comprise one or more ridges, or ribs, that are raised from the inner surface of tubular portion 102. In some embodiments, engagement surfaces on housing 100 (e.g., engagement surfaces 112 within tubular portion 102) may instead or additionally comprise one or spring-loaded arms and / or one or more deformable tabs disposed along the inner surface of tubular portion 102. In any instance, at least a portion of the one or more engagement surfaces 112 may extend from the inner surface of tubular portion 102 toward a central longitudinal axis of tubular portion 102. Thus, when the syringe barrel is inserted into tubular portion 102 of housing 100, the one or more engagement surfaces 112 may contact the syringe (e.g., the barrel of the syringe) to at least provide traction and stability between the housing 100 and the syringe. In some embodiments, the one or more engagement surfaces 112 may prevent retraction of the syringe from the housing 100 when a portion of the syringe (e.g., a portion of the syringe barrel) is advanced until, or passed, the one or more engagement surfaces. For example, in the instance the one or more engagement surfaces 112 comprises one or more spring-loaded arms,once advancement of the syringe passes the spring-loaded arm(s), the syringe may catch on the spring-loaded arm(s) to prevent retraction of the syringe from the housing 100. The body of the syringe may comprise one or more external features (e.g., tabs extending from an external surface of the syringe) that may engage with the one or more engagement surfaces 112 on housing 100.

[0088] The single monolithic housing 100 may be configured to fixedly attach to the syringe, such as the syringe barrel, syringe flanges, etc., when the barrel of the syringe is received in the tubular portion 102 of the housing 100. For example, one or more of the aforementioned latches (e.g., latches on receiving portions 110, engagement surfaces 112, latches 105, etc.) may fixedly attach the housing 100 to the syringe. Thus, once assembled, housing 100 and the syringe barrel may not translate relative to one another. Rather, in this scenario, only the plunger (e.g., plunger rod) of the syringe may be advanced within the syringe barrel.

[0089] In some embodiments, the syringe accessory may be single use. For example, after use, the syringe and syringe accessory may be appropriately disposed of together. As described herein, the housing 100 may fixedly attach to the syringe, although it is to be understood that, under a predetermined amount of force applied by a user, the housing 100 may also be removably attached to the syringe. Thus, it is envisaged that housing 100 may in some embodiments be detached from the syringe and may then be sterilized to allow at least the syringe accessory to be re-used.

[0090] The single monolithic housing 100 may comprise a transparent material, a semi-transparent material, and / or an opaque material. For example, FIGS. 3A-3B and FIG. 4 illustrate syringe accessories comprising housings with transparent materials. Housing 100 may comprise one or more cut-outs, for example, in the instance at least a portion of the housing material is opaque. The cut-outs may allow a user of the syringe accessory to view the fluid level and / or any markings on the syringe barrel during use. The material of the housing 100 may comprise polycarbonate, polypropylene, polyethylene, polyether ether ketone (PEEK), polyphenylsulfone (PPSU), polyethylene terephthalate (PET), polyethylene terephthalate glycol (PETG), acrylonitrile butadiene styrene (ABS), acrylonitrile styrene acrylate (ASA), or a mixture of polymers.

[0091] In some embodiments, the material of housing 100 may be selected such that a component of the syringe, such as the one or more flanges, a portion of the syringe barrel, etc. can deform to removably lock into place in housing 100. In other words, the material of the housing 100 may be stiffer, or stronger, than that of the syringe. Alternatively, in some embodiments, the opposite scenario could take place in which the material of housing 100 is selected such that a portion ofthe housing 100 (e.g., one or more latches, ribs, ridges, clips, tabs, etc. on housing 100) can deform when the syringe is inserted to the housing 100. In a non-limiting example, a polycarbonate syringe accessory may be manufactured that can be stiffer than a polypropylene syringe.

[0092] In some embodiments, the syringe accessory may comprise housing 100. That is, the syringe accessory described herein may comprise additional components, pieces, or features that are not embodied within housing 100. Alternatively, in some embodiments, the syringe accessory may be housing 100. That is, the syringe accessory may not comprise any additional components other than that which is described herein with respect to housing 100. Housing 100 may be a single monolithic body. The single monolithic body may be manufactured from a single piece of material, e.g., using injection molding or other techniques known to one of ordinary skill in the art. However, it is also envisaged that housing 100 may comprise more than one body, such as 2, 3, or 4 bodies. In one example, tubular portion 102 may comprise a first body, flanges 104 may comprise a second body, and base portion 106 may comprise a third body, each of the individual bodies removably attachable. Other combinations of features of the syringe accessory (e.g., tubular portion 102, flanges 104, and base portion 106) across different bodies are understood to be encompassed by the disclosure provided herein.

[0093] FIGS. 2A-2G illustrate a syringe accessory in accordance with a second embodiment, the syringe accessory comprising a single monolithic housing 200. The syringe accessory comprising housing 200 may comprise any one or more features of the syringe accessory comprising housing 100 as described herein with respect to FIGS. 1 A- 1G. For example, the housing 200 may comprise a tubular portion 202 configured to receive a barrel of a syringe, one or more flanges 204 at proximal end of tubular portion 202, and a base portion 206 at a distal end of tubular portion 202. The base portion 206 may extend outward in at least one direction from an outer surface of tubular portion 202 toward an end of base portion 206.

[0094] In some embodiments, housing 200 may differ from housing 100 in that housing 200 (e.g., tubular portion 202) may not comprise a constriction. For example, tubular portion 202 may be configured to receive any syringe size described herein with respect to tubular portion 102. However, in some embodiments (e.g., for syringes with smaller volume capacities), the syringe accessory may not necessitate a constriction to limit advancement of the syringe barrel through the housing (e.g., as shown at least in FIG. 2C). In this instance, advancement of the syringe through tubular portion 202 may instead be limited by one or more receiving portions 210 in flanges 204configured to receive flanges of the syringe, one or more latches 205, one or more engagement surfaces 212, etc. The receiving portions 210, latches 205, and engagement surfaces 212 may comprise any one or more features of receiving portions 110, latches 205 and engagement surfaces 112, respectively, described herein with respect to FIGS. 1A-1G.

[0095] FIGS. 3 A and 3B illustrate syringe and housing assemblies 150 and 250. For example, the assembly 150 illustrated in FIG. 3A may comprise the syringe accessory (e.g., housing 100) illustrated in and described with respect to FIGS. 1A-1G and a syringe 120. The assembly 250 illustrated in FIG. 3B may comprise the syringe accessory (e.g., housing 200) illustrated in and described with respect to FIGS. 2A-2G and a syringe 220. The features described herein with respect to assembly 150 and FIG. 3A are understood to be applicable to assembly 250 and FIG. 3B, and vice versa.

[0096] The syringe 120 illustrated in FIG. 3A may comprise conventional syringe features known to one of ordinary skill in the art, including a syringe barrel 122, needle 124, plunger 126, and in some embodiments, a removable cap 128. The syringe 220 illustrated in FIG. 3B may comprise similar features, including syringe barrel 222, needle 224, plunger 226, and removable cap 228. Plungers 126 and 226 may comprise a plunger stopper at a distal end of the plunger and a plunger rod extending from the plunger stopper. As described herein, syringe 120 and / or syringe 220 may comprise additional features not explicitly stated. For example, syringes comprising other needle safety features (e.g., a pivoting needle shield, retractable needle, a stopper, etc.) are understood to be encompassed by the syringes described herein.

[0097] As described herein, housing 100 may be configured to limit needle protrusion length, for example, beyond the base portion 106 of housing 100. For example, housing 100 may comprise one or more engagement surfaces 112, latches 105, and / or a constriction 108 configured to limit movement of the syringe within housing 100 and in turn limit the amount of needle that is not shielded within housing 100. In some embodiments, the single monolithic housing 100 may be configured to limit protrusion of a needle 124 to between about 4 mm and 12 mm passed the end of housing 100 (e.g., the end of base portion 106). In some embodiments, housing 100 may limit protrusion of needle 124 to less than or equal to about 12 mm, 11 mm, 10 mm, 9 mm, 8 mm, or 7 mm passed the end of base portion 106. In some embodiments, housing 100 may limit protrusion of needle 124 to greater than or equal to about 4 mm, 5 mm, 6 mm, 7 mm, 8 mm, 9 mm, or 10 mm.

[0098] The needle 124 coupled to the distal end of syringe 120 may comprise a Luer lock needle or Leur slip needle (e.g., a concentric slip or eccentric slip needle). In some embodiments, needle 124 may comprise a conventional needle or a safety needle. For example, the needle 124 may be retractable into the barrel 122 of the syringe, the needle may be detachable from the remainder of the syringe 120, and / or as described herein, the needle 124 may be protected within cap 128. For example, cap 128 may be removable from syringe 120, or in some embodiments may pivot between an open and closed position to cover the needle 124 before and / or after use.

[0099] In some embodiments, the barrel 122 of syringe 120 may be pre-filled. For example, the syringe barrel 122 may be pre-filled with an active pharmaceutical ingredient (API).

[0100] FIGS. 4A-4B illustrate assemblies 350, 450 relative to injection sites. The assembly 350 may comprise a syringe accessory (e.g., housing 300) and syringe 320. In a similar nature, the assembly 450 may comprise a syringe accessory (e.g., housing 400) and syringe 420. In some embodiments, the assemblies 350, 450 may comprise the assembly 150 (e.g., housing 100 and syringe 120) or assembly 250 (e.g., housing 200 and syringe 220). Each of the features described herein with respect to assembly 350 are understood to be applicable to assembly 450, and vice versa.

[0101] As illustrated in FIG. 4 A, housing 300 may be configured to raise a portion of skin 330 at the injection site 340. The raised skin 330 may be within a perimeter of the base portion 306 when the base portion 306 is in contact with the injection site 340. In other words, as shown, the housing 300 may be configured to create a “bubble” of skin 330 that can ease injection at the injection site 340. FIG. 4A may illustrate an embodiment in which the contact surface provided by housing 300 at the injection site 340 is based on an outer portion of the base portion 306 (e.g., as described above with respect to base portion 106 illustrated in FIGS. 1A-1G). The base portion 306 of housing 300 may additionally comprise an inner portion (e.g., inner portion 116 differentiated from the outer portion 114 of base portion 106, illustrated in FIG. 1G), however, said inner portion may not have an effect on the manner by which the skin 330 is raised at the injection site 340.

[0102] FIG. 4B illustrates a similar embodiment in which the skin 430 can be raised at the injection site 440 when the base portion 406 is in contact with injection site 440. FIG. 4B may illustrate an embodiment in which the contact surface provided by housing 400 at the injection site 440 is based on an outer portion and an inner portion of the base portion 406 (e.g., outer portion 114 and inner portion 116 illustrated in and described above with respect to FIG. 1G). The base portion 406 ofhousing 400 may comprise a void between the outer portion and inner portion of the base portion 406 (e.g., described herein at least with respect to FIG. 1G), in which a portion of the skin 430 may be raised into, as illustrated. The skin 430 may instead or additionally be raised by the base portion 406 of housing 400 into an opening surrounded by said inner portion (e.g., through which the syringe needle passes).

[0103] As described herein, housing 300 may be configured to limit the protrusion of the syringe needle beyond of the housing (e.g., beyond the base portion of the housing). Thus, housing 300 may be configured to limit the depth that the needle can be injected into the skin. For example, housing 300 may limit the needle to be injected into the subcutaneous layer of the skin, into muscle (e.g., intramuscular), into the dermis layer of the skin (e.g., intradermal, below the epidermis), or into veins (e.g., intravenous). The depth of the injection may be controlled by modifying the body length of the housing 300 and / or length of the needle used with the syringe, as will be understood by one of ordinary skill in the art.

[0104] As described herein, the end of base portion 306 may be configured to provide a stable contact surface on an injection site. For example, the base portion 306 may provide a consistent injection angle between 80° and 100° that is measured between a plane co-planar with the end surface of base portion 306 and an axis orthogonal to said plane (e.g., the Y-axis illustrated in FIGS. 1A-1D and 1G). In some embodiments, the injection angle provided by base portion 106 may be greater than or equal to 80°, 82°, 85°, 88°, or 90°. In some embodiments, the injection angle provided by base portion 106 may be less than or equal to 100°, 98°, 95°, 92°, or 90°. For example, the injection angle may be between 80-95, 80-92, 80-90, 82-100, 82-95, 82-90, 85-100, 85-98, 85-95, 85-90, 88-100, 88-98, 88-95, 90-100, 90-98, or 90-95 degrees.

[0105] FIGS. 5A-5D illustrate another housing 500 of a syringe accessory, features of which are understood to be usable in any of the syringe accessory housings (e.g., housing 100, 200, etc.) described herein. The housing 500 illustrated in FIGS. 5A-5D may differ from those previously described in that the housing 500 may include a locking member 508 disposed at a proximal end of the tubular portion 502 for retaining a syringe 520 within the housing 500 (as shown in the assembly 550 in FIG. 5B).

[0106] The locking member 508 may be positioned at a proximal end of the tubular portion 502, at least partially within the one or more flanges 504. The locking member 508 can include an elongated portion 512 for limiting translation of the locking member 508 within the housing 500.The locking member 508 can include a central portion 514 that engages with the syringe 520 when inserted to the tubular portion 502. The central portion 514 may be configured to limit axial movement of the locking member 508 within the housing. The locking member 508 may be moveable (e.g., translatable) from an unlocked position in which the syringe 520 can be inserted to the tubular portion 502 of the housing 500, and a locked position in which the syringe 520 can be locked within the tubular portion 502 by the locking member 508. FIGS. 5A-5D illustrate the housing 500 and locking member 508 thereof in the locked position. The features of the housing 500 and the locking member 508 thereof that can enable this locking mechanism are described below.

[0107] The housing 500 may include a track 518 configured to maintain the position of the locking member 508 along the X-axis. The track 518 may be disposed within the one or more flanges 504 to receive the elongated portion 512 of the locking member 508. The track 518 may be configured to limit movement of the locking member 508 along the X-axis. For example, the track 518 may include one or more openings 519 along a length of the track 518 that are configured to receive one or more fins 513 protruding from the elongated portion 512. Once the one or more fins 513 are disposed within the one or more openings 519, the movement of the locking member 508 can be limited (e.g., within a threshold amount of movement).

[0108] The housing 500 may include a slot 521 at the outer end of the one or more flanges 504 that is configured to receive the elongated portion 512 of the locking member 508. In the unlocked position (i.e., the position in which the housing 500 may be provided for inserting the syringe 520 to the housing 500), the elongated portion 512 may extend outside of the housing 500 through the slot 521. The elongated portion 512 may be deformable such that the fins 513 can be contracted within the track 518 in this unlocked position. For example, the elongated portion 512 can include one or more elongated members 511 separated by one or more openings 516 for deforming the elongated portion 512. In the example illustrated in FIGS. 5A-5D, the elongated portion 512 may include three elongated members 511 separated by two openings 516. The fins 513 can be disposed on one or more of the outermost elongated members 511. To advance the locking member 508 to the locked position, the user can push the end of the elongated portion 512 extending outside of the housing 500 through the slot 521 and along the track 518 until the one or more fins 513 are caught in the one or more openings 519 of the track 518. The one or more openings 519 may be positioned along the length of the track 518 such that when the fins 513 are received therein, thecentral portion 514 of the locking member 508 is positioned to retain the syringe 520 within the housing 500.

[0109] In some examples, the locking member 508 may be configured to removably lock the syringe 520 in place within the housing 500. For example, the elongated portion 512 may be deformable to allow the locking member 508 to be moved back to the unlocked position after use in the locked position. In this example, the one or more fins 513 may be configured to contract back into the track 518 after being disposed in the one or more openings 519 in the locked position. In this way, the syringe 520 can be removed from the housing 500 after use and the housing 500 can be reused.

[0110] The housing 500 may include one or more slots 510 configured to maintain the position of the locking member 508 within an X-Y plane. The one or more slots 510 can be disposed at the proximal end of the tubular portion 502 to receive one or more outer tabs 515 protruding outward from the central portion 514 of the locking member 508, away from the longitudinal axis of the tubular portion 502. The one or more outer tabs 515 may be translatable within the one or more slots 510 of the housing 500 in the unlocked and the locked position of the locking member 508. The central portion 514 may include one or more inner tabs 517 that protrude outward from the central portion 514, toward the longitudinal axis of the tubular portion 502. In the locked position of the locking member 508, the one or more inner tabs 517 can extend over the syringe 520 to hold the syringe 520 in place.

[0111] FIGS. 6A-6B illustrate another housing 600 of a syringe accessory, features of which are understood to be usable in any of the syringe accessory housings (e.g., housing 100, 200, etc.) described herein. The housing 600 illustrated in FIGS. 6A-6B may differ from those previously described in that the housing 600 may include an opening 608 that extends at least a portion of the length of the tubular portion 602 and one or more retaining portions 612 configured to hold the syringe 620 (illustrated in the assembly 650 of FIG. 6B) in place when inserted to the tubular portion 602. The opening 608 may be sized (e.g., in length) such that the barrel of the syringe 620 can be inserted to the housing 600 through the opening 608. The opening 608 may extend only a portion of the circumference of the tubular portion 602, such that the tubular portion 602 still surrounds at least a portion of the syringe 620 when inserted therein.

[0112] Once the syringe 620 is inserted to the housing 600, the one or more retaining portions 612 can maintain the position of the syringe 620 within the tubular portion 602. For example, the oneor more retaining portions 612 may protrude into the lumen of the tubular portion 602 configured to receive the syringe 620. In this manner, when the syringe is inserted to the tubular portion 602, the one or more retaining portions 612 may be configured to firmly contact the syringe 620 to hold it in place. In some examples, a proximal end of the syringe 620 can include one or more syringe flanges 622, and the housing 600 can be configured to receive the syringe flanges 622 in one or more corresponding receiving portions 610. The one or more receiving portions 610 may be disposed at the proximal end of the tubular portion 602 proximate to the one or more flanges 604. In some examples, the one or more receiving portions 610 includes one or more slots, such as a single slot extending at least a portion of the circumference of the tubular portion 602 to correspond with the dimensions of the one or more syringe flanges 622. Using the one or more receiving portions 610 and / or the one or more retaining portions 612, the position of the syringe 620 within the housing 600 can be secured to ensure safe use of the syringe 620. In some examples, the syringe 620 may be removably secured within the housing 600. For example, the one or more retaining portions 612 may be deformable to the extent that a user may remove the syringe 620 from the housing 600 by pulling the syringe 620 out of the tubular portion 602.

[0113] FIGS. 7A-7B illustrate another housing 700 of a syringe accessory, features of which are understood to be usable in any of the syringe accessory housings (e.g., housing 100, 200, etc.) described herein. The housing 700 illustrated in FIGS. 7A-7B may differ from those previously described in that the housing 700 may include a door 708 for inserting and removing the syringe 720 (illustrated in the assembly 750 in FIG. 7B) from within the tubular portion 702. For example, the tubular portion 702 may include an opening similar to the opening 608 described with respect to housing 600 shown in FIGS. 6A-6B, and the door 708 may permit and limit access to said opening for inserting and removing the syringe 720 from the tubular portion 702. The door 708 may be coupled to the tubular portion 702 at a hinge 712 of the tubular portion 702. The door 708 may removably attach to the tubular portion 702 to retain the syringe 720 within the housing 700. For example, the door 708 may removably attach to the tubular portion 702 on the opposing side of the tubular portion 702 relative to the hinge 712.

[0114] As described with respect to housing 600 in FIGS. 6A-6B, the housing 700 may include one or more receiving portions 710 configured to receive one or more syringe flanges 722. The receiving portions 710 may include any one or more features described with respect to receiving portions 610. Using the one or more receiving portions 710 and / or the door 708, the syringe 720can be secured within the housing 700 for safe use of the syringe 720. In some examples, the syringe 720 may be removably secured within the housing 700. For example, the door 708 may be opened and the user may remove the syringe 720 from the housing 700 by pulling the syringe 720 out from within the tubular portion 702.

[0115] FIGS. 8A-8B illustrate another housing 800 of a syringe accessory, features of which are understood to be usable in any of the syringe accessory housings (e.g., housing 100, 200, etc.) described herein. The housing 800 illustrated in FIGS. 8A-8B may differ from those previously described in that the housing 800 may include an opening 808 that extends a length of the tubular portion 802 as well as a length of the base portion 806. The housing 800 may be particularly beneficial, for example, in cases in which the syringe 820 to be inserted to the housing 800 includes a needle safety feature that protrudes from the barrel of the syringe 820 (not explicitly illustrated in FIGS. 8A-8B; however, a similar syringe is shown in FIGS. 9A-9B described in greater detail below). The housing 800 is not intended to be limited to use with syringes having such needle safety features, though, and may be usable with syringes that do not include these features. For example, assembly 950 in FIG. 9B illustrates a syringe 820 disposed within the housing 800 that does not include any particular features protruding from the barrel of the syringe 820. Nonetheless, the housing 800 may retain the syringe 820 within the tubular portion 802 using one or more retaining portions 812 and / or receiving portions 810. As described above with respect to at least FIGS. 6A-6B and 7A-7B, the one or more retaining portions 812 can be configured to hold the syringe 820 in place within the tubular portion 802. The one or more receiving portions 810 may be configured to receive one or more syringe flanges 822 of the syringe 820. The housing 800 may be configured to removably secure the syringe 820 within the housing 800.

[0116] FIGS. 8C-8D illustrate the base portion 806 of the housing 800. It is to be understood that the base portion 806 can be used in any of the syringe accessory housings described herein (e.g., housing 100, 200, etc.). As noted above, the base portion 806 can include an opening 808 extending a length of the base portion 806. The base portion 806 may be configured to provide a stable surface on the skin of the patient despite this opening 808, because the opening 808 may only extend a portion of the circumference of the base portion 806. For example, the opening 808 may extend less than 50% around the circumference of the base portion 806 (e.g., 40%, 30%, 25%, 20%, or less), thus enabling the remainder of the distal end of the base portion 806 to provide a stable surface for injection. At least a distal portion of the inner surface 807 of the base portion806 may have a concave shape to receive the patient’s skin when the base portion 806 is applied with pressure to the patient’s skin, which can cause the skin to protrude into the base portion 806.

[0117] FIGS. 9A-9B illustrate another housing 900 of a syringe accessory, features of which are understood to be usable in any of the syringe accessory housings (e.g., housing 100, 200, etc.) described herein. The housing 900 illustrated in FIGS. 9A-9B may be similar to housing 700 described with respect to FIGS. 7A-7B in that housing 900 also includes a door 908. However, housing 900 may differ from housing 700 (and other previously described syringe accessory housings) in that the door 908 may extend only a portion of the length of the tubular portion 902. The purpose of a shorter door 908 may be, for example, to enable the housing 900 to be used with syringes that have one or more features (e.g., needle safety features) which protrude from the barrel of the syringe 920. An example of this is depicted in the assembly 950 in FIG. 9B, in which the syringe 920 includes a needle safety glide 926 (depicted in a contracted position) for shielding the needle of the syringe 920 after use. The door 908 and / or the one or more receiving portions 910 (disposed at the proximal end of the tubular portion 902 proximate to the one or more flanges 904) may be configured to secure the syringe 920 within the housing 900 for safe use of the syringe 920.

[0118] The housing 900 may further differ from earlier described housings in that the opening 914, a portion of which is coverable by the door 908, may extend at least a length of the base portion 906 (in addition to extending a length of the tubular portion 902). The opening 914 may extend the length of the tubular portion 902 as well as at least a portion of the length of the base portion 906 for multiple reasons. For example, the longer opening 914 can enable easier insertion of the syringe 920 into the housing 900. This can be beneficial if, for example, the syringe 920 being inserted to the tubular portion 902 includes additional accessories thereon that may increase the size of the syringe 920 being inserted to the housing 900. An example accessory can include a removable shield 924, as illustrated in FIG. 9B. Additionally or alternatively, the opening 914 that extends into the base portion 906 can ensure that full deployment of the needle safety glide 926 is enabled after use of the syringe 920.

[0119] As shown in FIGS. 9A-9B, the opening 914 may not extend the full length of the base portion 906. For example, the distal end of the base portion 906 may not have an opening along its side. The full distal surface of the base portion 906 can provide a stable surface for safe injection with the syringe 920. The base portion 906 is further illustrated in FIGS. 9C-9D. It is to beunderstood that features of the base portion 906 can be used for any of the housing base portions described herein. As shown, the base portion 906 can include a convex distal surface 916. This convex distal surface 916 can provide a smooth, stable engagement surface between the patient’s skin and the base portion 906 for a safe injection with the syringe. In some examples, applying the base portion 906 of the housing 900 to the patient’ s skin with pressure may cause a portion of the patient’s skin at the injection site to protrude into the lumen 915 of the base portion 906.

[0120] FIGS. 10A-10B illustrate another base portion 1006 for a syringe accessory housing that may be similar to base portion 906 described with respect to FIGS. 9A-9D. Base portion 1006 is understood to be usable in any of the housings described herein. Base portion 1006 may differ from base portion 906 in that the base portion 1006 may not include an opening therein. The base portion 1006 can include a similar convex distal surface 1016 that can provide a smooth and stable surface for injection on the patient’s skin. In some examples, skin at the injection site may protrude into the lumen 1015 of the base portion 1006 when a housing including the base portion 1006 is applied with pressure to the injection site.

[0121] FIGS. 11A-11B illustrate another base portion 1106 for a syringe accessory housing that may be similar to base portion 1006 described with respect to FIGS. 10A-10B. Base portion 1106 is understood to be usable in any of the housings described herein. Base portion 1106 may differ from base portion 1006 in that the base portion 1006 may include one or more ribs 1120 separating one or more openings 1118. The base portion 1106 can include a similar convex distal surface 1116 that, despite the openings 1118, can provide a smooth and stable surface for injection on the patient’s skin. The stable surface may be provided at least in part from the ribs 1120. In some examples, skin at the injection site may protrude into the lumen 1115 and / or the openings 1118 of the base portion 1106 when a housing including the base portion 1106 is applied with pressure to the injection site. Providing additional space for which the patient’s skin can protrude into when the base portion 1106 is applied to the injection site with pressure may be beneficial in creating a stable surface for injection. Additionally or alternatively, a benefit of base portion 1106 may be that the base portion 1106 is lighter in weight than alternative base portions that do not have any openings. This may also be a manufacturing benefit in that the base portion 1106 may require less material to produce.

[0122] FIGS. 12A-12B illustrate another base portion 1206 for a syringe accessory housing that can be usable in any of the housings described herein. In some examples, the base portion 1206may be similar at least to base portion 106 illustrated in FIGS. 1A-1G. However, the base portion 1206 may differ from base portion 106 in that the base portion 1206 can include an inner portion 1224 that extends distal to the outer portion 1222 of the base portion 1206. Stated another way, the distal end of the outer portion 1222 may extend to a first plane, and the distal end of the inner portion 1224 may extend to a second plane that is parallel to and distal of the first plane. During use, at least the distal end of the inner portion 1224 of the base portion 1206 may contact the patient’s skin. In some examples, dependent on the amount of pressure applied to the patient’s skin with the housing including the base portion 1206, the patient’s skin may contact the outer portion 1222, too. For example, the skin at the injection site may protrude into one or more openings 1218 between the inner portion 1224 and the outer portion 1222. Because the inner portion 1224 extends distal to the outer portion 1222, the skin may protrude into these one or more openings 1218 in addition to protruding into the lumen 1215 of the base portion 1206.

[0123] FIGS. 13A-13B illustrate a base portion 1306 for a syringe accessory housing that can be usable in any of the housings described herein. In some examples, the base portion 1306 may be similar at least to base portion 106 illustrated in FIGS. 1A-1G. The base portion 1306 may be optimized such that the diameters of each of the inner portion 1324 and the outer portion 1322 create a stable surface at the injection site.

[0124] During use, the distal end of each of the inner portion 1324 and the outer portion 1322 of the base portion 1206 may contact the patient’s skin. When pressure is applied to the skin by the base portion 1306, the skin at the injection site may protrude into one or more openings 1318 between the inner portion 1324 and the outer portion 1322 and / or into the lumen 1315 within the inner portion 1324.

[0125] FIGS. 14A-14B illustrate another base portion 1406 for a syringe accessory housing that can be usable in any of the housings described herein. Base portion 1406 may be similar to base portion 1306 described with respect to FIGS. 13A-13B, except that base portion 1406 may not include a distinct inner portion 1324 and outer portion 1322. Instead, base portion 1406 may include only an outer portion 1422. The distal end of the outer portion 1422 can provide a stable surface for injection on the patient’s skin. For example, the outer portion 1422 may extend (or flare) outward toward the distal end in one or more directions. The base portion 1006 can include a concave distal surface 1407, into which the skin may protrude when pressure is applied to the patient’s skin during use of a housing including the base portion 1406.

[0126] FIGS. 15A-15B illustrate another base portion 1506 for a syringe accessory housing that can be usable in any of the housings described herein. Base portion 1506 may differ from previously described and illustrated base portions (e.g., base portion 1406) in that the outer surface 1522 of the base portion 1506 may recede inward toward a longitudinal axis of the base portion 1506 as the base portion 1506 extends distally. Thus, the base portion 1506 may not include a concave or convex distal surface for contacting the patient’s skin. Rather, the distal end of the outer surface of the 1522 that contacts the injection site may be the minimum diameter of the base portion 1506 and thus may provide a minimal contact surface with the skin. This embodiment may be beneficial for more experienced users in which some amount of support is desired from a syringe accessory, but the user also desires to manipulate the angle at which the syringe having the accessory thereon contacts the injection site. A housing having the base portion 1506 may be manipulated in this fashion due to the rounded outer surface 1522 that decreases in diameter as it extends to the distal end of the base portion 1506. When the base portion 1506 is applied to the injection site with pressure, skin at the injection site may protrude into the lumen 1515 of the base portion 1506.

[0127] FIG. 16 illustrates an additional feature that may be included on the housings described herein. FIG. 16 illustrates of a portion of a tubular portion 1602 that includes a finger pad 1603 disposed along a length of the tubular portion 1602, in accordance with some embodiments. The finger pad 1603 is reasonably understood to be usable in any of the housings described herein. The finger pad 1603 may be configured ergonomically such that the user may grip the finger pad 1603 during use of the syringe having the syringe accessory thereon to improve dexterity with the device. The finger pad 1603 may be positioned at any desired position along the length of the tubular portion 1602. For example, the finger pad 1603 may be positioned along a distal portion, a proximal portion, or between the distal and proximal portion of the tubular portion 1602.Methods of Assembling a Syringe and Syringe Assembly

[0128] Methods of assembling a syringe accessory and a syringe are provided herein. For example, the syringe accessory may comprise 100 or 200 described herein with respect to FIGS. 1A-1G and 2A-2G, respectively. Accordingly, the syringe accessory described herein may comprise a single monolithic housing comprising the tubular portion, one or more flanges at the proximal end of the tubular portion, and a base portion at the distal end of the tubular portion. The base portion mayextend outward in at least one direction from an outer surface of the tubular portion toward an end of the base portion to provide a stable contact surface on an injection site. The syringe may comprise features of syringes described herein, such as features of a conventional manual syringe (e.g., a barrel, plunger rod, plunger stopper, needle, and one or more flanges). The method is further understood to be applicable to the syringe accessories and assemblies having the syringe therein as illustrated in FIGS. 5A-5B, 6A-6B, 7A-7B, 8A-8D, and 9A-9B.

[0129] The method may include inserting a barrel of the syringe into a proximal end of a tubular portion of the syringe accessory. For example, the end of the syringe barrel that is coupled (or will be coupled) to the needle may be inserted into a proximal end of the tubular portion.

[0130] The method may include advancing the barrel toward a distal end of the tubular portion. The syringe barrel may be advanced until one or more flanges of the syringe clips on one or more latches on an inner surface of the syringe accessory. For example, the one or more latches may be disposed in one or more receiving portions of the one or more flanges and / or at a distal end of a tubular portion of the single monolithic housing. The one or more latches may extend from the inner surface of the syringe accessory (e.g., an inner surface of the one or more flanges and / or a tubular portion of the housing) toward a central longitudinal axis of the tubular portion of the housing. Thus, the one or more latches may clip the syringe flanges to prevent retraction of the syringe from the syringe accessory when the one or more flanges of the syringe are advanced distally passed the one or more latches. In some embodiments, the one or more latches disposed on an inner surface of the syringe accessory may additionally or alternatively comprise one or more engagement surfaces, such as one or more ribs, ridges, spring-loaded arms, and / or one or more deformable tabs on the inner surface of the tubular portion. In any instance, the single monolithic housing may fixedly attach to the barrel of the syringe when the barrel of the syringe is fully inserted into the tubular portion of the single monolithic housing.

[0131] The tubular portion may comprise a proximal portion that can receive the barrel of the syringe and a distal portion that can shield at least a portion of a needle of the syringe when the barrel is inserted in the proximal portion. In some embodiments, the tubular portion may comprise a constriction along a length of the tubular portion between the proximal portion and the distal portion that can limit protrusion of the needle when the barrel of the syringe is inserted into the proximal portion of the tubular portion.

[0132] Following assembly of the syringe and syringe accessory, the assembly may be used to inject an API. The syringe and syringe accessory assembly may provide a stable contact surface for injection, as well as a consistent injection angle. Methods for injecting an API using the syringe and syringe accessory assembly described herein are provided below.Methods of Injecting an API with a Syringe and Syringe Accessory

[0133] Methods of using the syringe accessory with a syringe is provided herein. For example, a method of injecting an active pharmaceutical ingredient (API) contained in a syringe is provided herein. The syringe can be housed in a syringe accessory described in accordance with embodiments provided herein. For example, the syringe accessory may comprise housing 100 or 200 described herein with respect to FIGS. 1A-1G and 2A-2G, respectively. Accordingly, the syringe used for injection may be housed in a single monolithic housing comprising a tubular portion that receives a barrel of the syringe, one or more flanges at proximal end of the tubular portion, and a base portion at a distal end of the tubular portion. The method is further understood to be applicable to the syringe accessories and assemblies having the syringe therein as illustrated in FIGS. 5A-5B, 6A-6B, 7A-7B, 8A-8D, and 9A-9B.

[0134] The syringe may be pre-loaded with the API. Alternatively, in some embodiments, the method may include loading the syringe with the API. For example, the syringe may be loaded by a user prior to assembling the syringe and syringe accessory.

[0135] The method may include inserting the syringe into the single monolithic housing, as described above in the example method of assembling a syringe and syringe accessory. In some embodiments, inserting the syringe into the syringe accessory may comprise advancing the syringe into the tubular portion of the housing until one or more flanges of the syringe contacts one or more latches disposed on an inner surface of the one or more flanges and / or the tubular portion of the housing. The one or more latches may clip the one or more flanges of the syringe when the one or more flanges are advanced distally passed the one or more latches to prevent retraction of the syringe from the housing. In some embodiments, the one or more latches may comprise one or more engagement surfaces, such as ribs, ridges, clips, spring-loaded arms, and / or one or more deformable tabs disposed on an inner surface of the tubular portion of the housing.

[0136] In some embodiments, inserting the syringe into the single monolithic housing may additionally or alternatively comprise advancing the syringe into the tubular portion of the housinguntil a distal end of the syringe barrel contacts a constriction along a length of the tubular portion. For example, the tubular portion of the single monolithic housing may comprise aa proximal portion that receives the syringe barrel and a distal portion that shields at least a portion of the needle when the barrel is received in the proximal portion. The distal portion and proximal portion may be distinguished by a constriction. In this manner, the housing may limit protrusion of the needle when the syringe is received in the tubular portion of the housing (e.g., in the proximal portion of the tubular portion) before use (e.g., even if the needle is not yet inserted into the injection site).

[0137] In any instance, as described herein, the single monolithic housing may fixedly attach to the barrel of the syringe when the barrel is fully inserted into the tubular portion of the housing.

[0138] In some embodiments, the needle of the syringe may be protected by a removable cap. Thus, the method may include removing the cap from the needle prior to inserting the needle into the injection site and subsequently injecting the API.

[0139] The method may include inserting the needle of the syringe (the syringe disposed in the single monolithic housing) into an injection site. Inserting the needle into the injection site may comprise advancing the needle into the injection site until the end of the base portion providing the stable contact surface contacts the injection site. In some embodiments (e.g., in the instance the syringe comprises a retractable needle feature), the syringe accessory may first be placed on the injection site such that the base portion contacts the injection site prior to advancing the needle into the injection site. In this instance, prior to use, substantially all of the needle may be shielded by the syringe accessory, and the syringe needle may be advanced toward the injection site to contact the site while the housing maintains stable contact at the injection site. The base portion may raise a portion of the skin at the injection site when the base portion is in contact with the injection site. For example, at least a portion of skin within a perimeter of the base portion may be raised based on contact with the base portion.

[0140] The method may include injecting the API contained in the syringe at the injection site at a depth of the needle limited by the single monolithic housing. For example, the housing may limit the depth of the injection to a subcutaneous, intramuscular, intradermal, and / or intravenous injection site. In some embodiments, a combination of needle length and features of the housing (e.g., latches, constrictions, etc.) may provide the desired needle protrusion length from the syringe and syringe accessory assembly. For example, at least the single monolithic housing may limit thedepth of the needle injected at the injection site to between 4 mm and 12 mm (e.g., for subcutaneous injection), the depth dependent on the desired injection site. For example, an intramuscular injection may necessitate a longer needle depth, whereas a dermal injection may necessitate a shorter needle depth. As described herein, during injection of the API into the injection site, the single monolithic housing (e.g., the base portion of the housing) may provide a consistent injection angle relative to the injection site. For example, the injection angle may be between 85 degrees and 95 degrees.

[0141] In some embodiments, injection of an API using the syringe and syringe accessory assembly provided herein may be achieved using a syringe device which embodies at least each of the features described herein with respect to the various embodiments of syringe accessories. For example, the syringe device may provide a stable contact surface and consistent injection angle. Exemplary syringe devices and methods of use thereof are provided in below.Syringe Devices

[0142] In some embodiments, a syringe device comprising one or more features of the syringe accessories described herein may be provided. Although illustrated and described herein as a housing configured to receive the syringe, it is envisaged that the syringe and housing may be provided as a single piece. For example, with reference to FIG. 3 A, the barrel 122 of syringe 120 may comprise any one or more features of housing 100 described herein. In such an embodiment, a syringe device may comprise at least a plunger and a single monolithic housing that comprises a barrel configured to receive the plunger (e.g., at least the plunger rod), one or more flanges at a proximal end of the barrel, and a base portion at a distal end of the barrel. The base portion of the syringe device may comprise any one or more features of base portion 106, 206, 306, and / or 406 described herein with respect to FIGS. 1A-1G, 2A-2G, and 4A-4B. For example, the base portion may extend in at least one direction from an outer surface of the barrel toward an end of the base portion that is configured to provide a stable contact surface on an injection site. More generally, the housing may comprise any one or more features described herein with respect to housings 100, 200, 300, and / or 400 described herein with respect to FIGS. 1A-1G, 2A-2G, 3A-3B, and / or 4A- 4B. For example, the housing may be a single monolithic housing that is configured to limit protrusion of a needle when the needle is coupled to the distal end of the barrel.Methods of Injecting an API with a Syringe Device

[0143] Methods of using the aforementioned syringe devices are provided herein. For example, a method of injecting an active pharmaceutical ingredient (API) contained in a syringe is provided herein. The syringe device used in the methods may comprise any one or more features of the aforementioned syringe device described in accordance with embodiments provided herein. For example, the syringe device used for injection may comprise at least a plunger and a single monolithic housing that comprises a barrel configured to receive the plunger (e.g., at least the plunger rod), one or more flanges at a proximal end of the barrel, and a base portion at a distal end of the barrel.

[0144] The syringe device may be pre-loaded with the API. Alternatively, in some embodiments, the method may include loading the syringe device with the API. For example, the syringe may be loaded by a user prior to assembling the syringe and syringe accessory.

[0145] In some embodiments, the needle of the syringe device may be protected by a removable cap. Thus, the method may include removing the cap from the needle prior to inserting the needle into the injection site and subsequently injecting the API.

[0146] The method may include inserting the needle of the syringe device into an injection site. Inserting the needle into the injection site may comprise advancing the needle into the injection site until the end of the base portion providing the stable contact surface contacts the injection site. In some embodiments (e.g., in the instance the syringe comprises a retractable needle feature), the syringe device may first be placed on the injection site such that the base portion contacts the injection site prior to advancing the needle into the injection site. In this instance, prior to use, substantially all of the needle may be shielded by the syringe device, and the syringe needle may be advanced toward the injection site to contact the site while the housing maintains stable contact at the injection site. The base portion may raise a portion of the skin at the injection site when the base portion is in contact with the injection site. For example, at least a portion of skin within a perimeter of the base portion may be raised based on contact with the base portion.

[0147] The method may include injecting the API contained in the syringe at the injection site at a depth of the needle limited by the single monolithic housing. For example, the housing may limit the depth of the injection to a subcutaneous, intramuscular, intradermal, and / or intravenous injection site. In some embodiments, a combination of needle length and features of the housing (e.g., latches, constrictions, etc.) may provide the desired needle protrusion length from the syringeand syringe accessory assembly. For example, at least the single monolithic housing may limit the depth of the needle injected at the injection site to between 4 mm and 12 mm, the depth dependent on the desired injection site. As described herein, during injection of the API into the injection site, the single monolithic housing (e.g., the base portion of the housing) may provide a consistent injection angle relative to the injection site. For example, the injection angle may be between 85 degrees and 95 degrees.

[0148] Unless defined otherwise, all terms of art, notations, and other technical and scientific terms or terminology used herein are intended to have the same meaning as is commonly understood by one of ordinary skill in the art to which the claimed subject matter pertains. In some cases, terms with commonly understood meanings are defined herein for clarity and / or for ready reference, and the inclusion of such definitions herein should not necessarily be construed to represent a substantial difference over what is generally understood in the art.

[0149] As used herein, the singular forms “a,” “an,” and “the” are intended to include the plural forms as well, unless the context clearly indicates otherwise. It is also to be understood that the term “and / or” as used herein refers to and encompasses any and all possible combinations of one or more of the associated listed items. It is further to be understood that the terms “includes, “including,” “comprises,” and / or “comprising,” when used herein, specify the presence of stated features, integers, steps, operations, elements, components, and / or units but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, units, and / or groups thereof.

[0150] The numerical ranges disclosed inherently support any range or value within the disclosed numerical ranges, including the endpoints, even though a precise range limitation is not stated verbatim in the specification because this disclosure can be practiced throughout the disclosed numerical ranges.

[0151] The foregoing description, for the purpose of explanation, has been described with reference to specific embodiments. However, the illustrative discussions above are not intended to be exhaustive or to limit the invention to the precise forms disclosed. Many modifications and variations are possible in view of the above teachings. The embodiments were chosen and described in order to best explain the principles of the techniques and their practical applications. Others skilled in the art are thereby enabled to best utilize the techniques and various embodiments with various modifications as are suited to the particular use contemplated.

[0152] Although the disclosure and examples have been fully described with reference to the accompanying figures, it is to be noted that various changes and modifications will become apparent to those skilled in the art. Such changes and modifications are to be understood as being included within the scope of the disclosure and examples as defined by the claims.EMBODIMENTS

[0153] Embodiment 1. A syringe accessory, comprising: a single monolithic housing comprising: a tubular portion configured to receive a barrel of a syringe; one or more flanges at a proximal end of the tubular portion; and a base portion at a distal end of the tubular portion that extends outward in at least one direction from an outer surface of the tubular portion toward an end of the base portion that is configured to provide a stable contact surface on an injection site, wherein the single monolithic housing is configured to limit protrusion of a needle of a syringe when the barrel of the syringe is received in the tubular portion.

[0154] Embodiment 2. The syringe accessory of claim 1 , wherein the base portion comprise a cross-sectional dimension that is larger than a cross-sectional dimension of the tubular portion.

[0155] Embodiment 3. The syringe accessory of embodiment 1 or 2, wherein the base portion comprises a flared shape extending outward from the outer surface of the tubular portion toward the end of the base portion providing the stable contact surface.

[0156] Embodiment 4. The syringe accessory of any one of embodiments 1-3, wherein the base portion is configured to raise a portion of skin at the injection site that is within a perimeter of the base portion when the base portion contacts the injection site.

[0157] Embodiment 5. The syringe accessory of any one of embodiments 1-4, wherein the single monolithic housing is configured to provide an injection angle relative to the contact surface between 85 degrees and 95 degrees.

[0158] Embodiment 6. The syringe accessory of any one of embodiments 1-5, wherein the single monolithic housing comprises one or more latches extending from an inner surface of the housing toward a central longitudinal axis of the tubular portion.

[0159] Embodiment 7. The syringe accessory of embodiment 6, wherein the one or more latches are disposed at the proximal end of the tubular portion and are configured to clip the syringebarrel when the syringe barrel is advanced distally passed the one or more latches to prevent retraction of the syringe from the single monolithic housing.

[0160] Embodiment 8. The syringe accessory of embodiment 6 or 7, wherein the one or more latches comprises one or more ribs, spring-loaded arms, and / or one or more deformable tabs disposed on an inner surface of the tubular portion.

[0161] Embodiment 9. The syringe accessory of any one of embodiments 1-8, wherein the tubular portion of the single monolithic housing is configured to receive a barrel of a syringe with a volume capacity between 0.1 mL and 70 mL.

[0162] Embodiment 10. The syringe accessory of any one of embodiments 1-9, wherein the tubular portion of the single monolithic housing is configured to receive a barrel of a 3-mL syringe or a barrel of a 5-mL syringe.

[0163] Embodiment 11. The syringe accessory of any one of embodiments 1-10, wherein the single monolithic housing is configured to limit the protrusion of the needle to between 4 mm and 12 mm passed the end of the base portion.

[0164] Embodiment 12. The syringe accessory of any one of embodiments 1-11, wherein the syringe accessory is single use.

[0165] Embodiment 13. The syringe accessory of any one of embodiments 1-12, wherein the syringe accessory is the single monolithic housing.

[0166] Embodiment 14. The syringe accessory of any one of embodiments 1-13, wherein the tubular portion comprises a proximal portion that is configured to receive the barrel of the syringe and a distal portion that is configured to shield at least a portion of the needle of the syringe when the barrel is received in the proximal portion.

[0167] Embodiment 15. The syringe accessory of embodiment 14, wherein the tubular portion comprises a constriction along a length of the tubular portion between the proximal portion and the distal portion that is configured to limit the protrusion of the needle when the barrel of the syringe is received in the proximal portion of the tubular portion.

[0168] Embodiment 16. The syringe accessory device of embodiment 14 or 15, wherein the distal portion of the tubular portion comprises one or more latches extending from an inner surface of the tubular portion toward a central longitudinal axis of the tubular portion, the one or morelatches configured to provide traction when the barrel of the syringe is received in the proximal portion of the tubular portion.

[0169] Embodiment 17. The syringe accessory of any one of embodiments 1-16, wherein the single monolithic housing is configured to fixedly attach to the barrel of the syringe when the barrel of the syringe is received in the tubular portion of the single monolithic housing.

[0170] Embodiment 18. The syringe accessory of any one of embodiments 1-17, wherein the single monolithic housing is configured to limit depth of the needle when injected to a subcutaneous layer of skin and / or when injected intramuscular.

[0171] Embodiment 19. The syringe accessory of any one of embodiments 1-18, wherein the one or more flanges at the proximal end of the tubular portion are larger than one or more flanges of the syringe.

[0172] Embodiment 20. The syringe accessory of any one of embodiments 1-19, wherein the single monolithic housing comprises a transparent material, a semi-transparent material, or an opaque material with one or more cut-outs.

[0173] Embodiment 21. The syringe accessory of embodiment 20, wherein the material comprises polycarbonate, polypropylene, polyethylene, polyether ether ketone (PEEK), polyphenylsulfone (PPSU), polyethylene terephthalate (PET), polyethylene terephthalate glycol (PETG), acrylonitrile butadiene styrene (ABS), acrylonitrile styrene acrylate (ASA), or a mixture of polymers.

[0174] Embodiment 22. A syringe assembly, comprising: the syringe accessory of any one of embodiments 1-21; and a syringe.

[0175] Embodiment 23. The syringe assembly of embodiment 22, wherein the syringe comprises a Luer lock needle or a Luer slip needle coupled to a distal end of the barrel of the syringe.

[0176] Embodiment 24. The syringe assembly of embodiment 22 or 23, wherein, prior to use, the needle of the syringe is protected within a removable cap.

[0177] Embodiment 25. The syringe assembly of any one of embodiments 22-24, wherein the syringe is a pre-filled syringe comprising an active pharmaceutical ingredient (API).

[0178] Embodiment 26. A method of assembling a syringe and a syringe accessory, comprising: inserting a barrel of the syringe into a proximal end of a tubular portion of the syringe accessory; and advancing the barrel toward a distal end of the tubular portion until one or more flanges of the syringe clips on one or more latches on an inner surface of the syringe accessory, wherein the syringe accessory comprises a single monolithic housing comprising the tubular portion, one or more flanges at the proximal end of the tubular portion, and a base portion at the distal end of the tubular portion that extends outward in at least one direction from an outer surface of the tubular portion toward an end of the base portion to provide a stable contact surface on an injection site.

[0179] Embodiment 27. The method of embodiment 26, wherein the one or more latches are disposed at the proximal end of the tubular portion of the single monolithic housing such that the one or more latches prevent retraction of the syringe from the syringe accessory when the syringe barrel is advanced distally passed the one or more latches.

[0180] Embodiment 28. The method of embodiment 28, wherein the one or more latches extend from the inner surface of the syringe accessory toward a central longitudinal axis of the tubular portion.

[0181] Embodiment 29. The method of any one of embodiments 26-28, wherein the one or more latches comprises one or more ribs, spring-loaded arms, and / or one or more deformable tabs on the inner surface of the tubular portion.

[0182] Embodiment 30. The method of any one of embodiments 26-29, wherein the single monolithic housing is fixedly attached to the barrel of the syringe when the barrel of the syringe is fully inserted into the tubular portion of the single monolithic housing.

[0183] Embodiment 31. The method of any one of embodiments 26-30, wherein the tubular portion comprises a proximal portion that receives the barrel of the syringe and a distal portion that shields at least a portion of a needle of the syringe when the barrel is inserted in the proximal portion.

[0184] Embodiment 32. The method of embodiment 31, wherein the tubular portion comprises a constriction along a length of the tubular portion between the proximal portion andthe distal portion to limit protrusion of the needle when the barrel of the syringe is inserted into the proximal portion of the tubular portion.

[0185] Embodiment 33. The method of embodiment 31 or 32, wherein the distal portion of the tubular portion comprises one or more latches extending from an inner surface of the tubular portion toward a central longitudinal axis of the tubular portion to provide traction when the barrel of the syringe is received in the proximal portion of the tubular portion.

[0186] Embodiment 34. The method of any one of embodiments 26-33, wherein the barrel of the syringe has a volume capacity between 0.1 mL and 70 mL.

[0187] Embodiment 35. The method of any one of embodiments 26-34, wherein the syringe is a 3-mL syringe or a 5-mL syringe.

[0188] Embodiment 36. The method any one of embodiments 26-35, wherein the one or more flanges at the proximal end of the tubular portion are larger than the one or more flanges of the syringe.

[0189] Embodiment 37. The method of any one of embodiments 26-36, wherein the syringe accessory is the single monolithic housing.

[0190] Embodiment 38. A method of injecting an active pharmaceutical ingredient (API) contained in a syringe, comprising: inserting a needle of the syringe into an injection site, the syringe disposed in a single monolithic housing comprising: a tubular portion that receives a barrel of the syringe; one or more flanges at a proximal end of the tubular portion; and a base portion at a distal end of the tubular portion that extends outward in at least one direction from an outer surface of the tubular portion toward an end of the base portion to provide a stable contact surface on the injection site; and injecting the API at the injection site at a depth of the needle limited by the single monolithic housing.

[0191] Embodiment 39. The method of embodiment 38, comprising inserting the syringe into the single monolithic housing.

[0192] Embodiment 40. The method of embodiment 38 or 39, wherein inserting the syringe comprises advancing the syringe into the tubular portion until one or more flanges of the syringecontacts one or more latches disposed on an inner surface of the one or more flanges of the single monolithic housing.

[0193] Embodiment 41. The method of embodiment 40, wherein the one or more latches clip the one or more flanges of the syringe when the one or more flanges of the syringe are advanced distally passed the one or more latches to prevent retraction of the syringe from the single monolithic housing.

[0194] Embodiment 42. The method of embodiment 40 or 41, wherein the one or more latches comprises one or more spring-loaded arms and / or one or more deformable tabs on the inner surface of the tubular portion.

[0195] Embodiment 43. The method of any one of embodiments 38-42, wherein inserting the syringe comprises advancing the syringe into the tubular portion until the one or more flanges of the syringe is received by one or more receiving portions of the one or more flanges of the single monolithic housing.

[0196] Embodiment 44. The method of any one of embodiments 38-43, wherein inserting the syringe comprises advancing the syringe into the tubular portion until a distal end of the barrel of the syringe contacts a constriction along a length of the tubular portion.

[0197] Embodiment 45. The method of any one of embodiments 38-44, wherein inserting the needle into the injection site comprises advancing the needle into the injection site until the end of the base portion providing the stable contact surface contacts the injection site.

[0198] Embodiment 46. The method of any one of embodiments 38-45, wherein the base portion raises a portion of skin at the injection site that is within a perimeter of the base portion when the base portion contacts the injection site.

[0199] Embodiment 47. The method of any one of embodiments 38-46, wherein, during injection of the API at the injection site, the single monolithic housing provides an injection angle relative to the contact surface that is between 85 degrees and 95 degrees.

[0200] Embodiment 48. The method of any one of embodiments 38-47, wherein the barrel of the syringe has a volume capacity between 0.1 mL and 70 mL.

[0201] Embodiment 49. The method of any one of embodiments 38-48, wherein the syringe is a 3-mL syringe or a 5-mL syringe.

[0202] Embodiment 50. The method of any one of embodiments 38-49, wherein, during injection of the API at the injection site, the single monolithic housing limits the depth of the needle to between 4 mm and 12 mm.

[0203] Embodiment 51. The method of any one of embodiments 38-50, wherein the tubular portion comprises a proximal portion that receives the barrel of the syringe and a distal portion that shields at least a portion of the needle of the syringe when the barrel is received in the proximal portion.

[0204] Embodiment 52. The method of embodiment 51, wherein the distal portion of the tubular portion comprises one or more latches extending from an inner surface of the tubular portion toward a central longitudinal axis of the tubular portion to provide traction when the barrel of the syringe is received in the proximal portion of the tubular portion.

[0205] Embodiment 53. The method of any one of embodiments 38-52, wherein the single monolithic housing is fixedly attached to the barrel of the syringe when the barrel of the syringe is fully inserted into the tubular portion of the single monolithic housing.

[0206] Embodiment 54. The method of any one of embodiments 38-53, wherein the single monolithic housing limits the depth of the needle to a subcutaneous layer of skin and / or to an intramuscular injection.

[0207] Embodiment 55. The method of any one of embodiments 38-54, wherein the single monolithic housing limits protrusion of the needle of the syringe when the barrel of the syringe is received in the tubular portion and the needle is not yet inserted into the injection site.

[0208] Embodiment 56. The method of any one of embodiments 38-55, wherein the syringe is pre-loaded with the API.

[0209] Embodiment 57. The method of any one of embodiments 38-56, comprising loading the syringe with the API

[0210] Embodiment 58. The method of any one of embodiments 38-57, wherein, prior to use, the needle is protected by a removable cap, and the method comprises removing the cap from the needle.

[0211] Embodiment 59. A syringe, comprising: a plunger comprising a plunger stopper at a distal end of the plunger and a plunger rod extending from the plunger stopper; and a single monolithic housing, comprising:a barrel configured to receive the plunger rod; one or more flanges at a proximal end of the barrel; and a base portion at a distal end of the barrel that extends outward in at least one direction from an outer surface of the barrel toward an end of the base portion that is configured to provide a stable contact surface on an injection site, wherein the single monolithic housing is configured to limit protrusion of a needle when the needle is coupled to the distal end of the barrel.

[0212] Embodiment 60. The syringe of embodiment 1, wherein the base portion comprise a cross-sectional dimension that is larger than a cross-sectional dimension of the barrel.

[0213] Embodiment 61. The syringe of embodiment 59 or 60, wherein the base portion comprises a flared shape extending outward from the outer surface of the barrel toward the end of the base portion providing the stable contact surface.

[0214] Embodiment 62. The syringe of any one of embodiments 59-61, wherein the base portion is configured to raise a portion of skin at the injection site that is within a perimeter of the base portion when the base portion contacts the injection site.

[0215] Embodiment 63. The syringe of any one of embodiments 59-62, wherein the single monolithic housing is configured to provide an injection angle relative to the contact surface between 85 degrees and 95 degrees.

[0216] Embodiment 64. The syringe of any one of embodiments 59-63, wherein the barrel has a volume capacity between 0.1 mL and 70 mL.

[0217] Embodiment 65. The syringe of any one of embodiments 59-64, wherein the syringe is a 3-mL syringe or a 5-mL syringe.

[0218] Embodiment 66. The syringe of any one of embodiments 59-65, wherein the single monolithic housing is configured to limit the protrusion of the needle to between 4 mm and 12 mm passed the end of the base portion.

[0219] Embodiment 67. The syringe of any one of embodiments 59-66, wherein the syringe is single -use.

[0220] Embodiment 68. The syringe of any one of embodiments 59-67, wherein the syringe consists of the plunger and the single monolithic housing.

[0221] Embodiment 69. The syringe of any one of embodiments 59-68, wherein the single monolithic housing is configured to limit depth of the needle when injected to a subcutaneous layer of skin and / or when injected intramuscular.

[0222] Embodiment 70. The syringe of any one of embodiments 59-69, wherein at least the single monolithic housing comprises a transparent material, a semi-transparent material, or an opaque material.

[0223] Embodiment 71. The syringe of embodiment 70, wherein the material comprises polycarbonate, polypropylene, polyethylene, polyether ether ketone (PEEK), polyphenylsulfone (PPSU), polyethylene terephthalate (PET), polyethylene terephthalate glycol (PETG), acrylonitrile butadiene styrene (ABS), acrylonitrile styrene acrylate (ASA), or a mixture of polymers.

[0224] Embodiment 72. The syringe of any one of embodiments 59-71, wherein the distal end of the barrel is configured to couple to a Luer lock needle or a Luer slip needle.

[0225] Embodiment 73. The syringe of embodiment 72, wherein, prior to use, the needle of the syringe is protected within a removable cap.

[0226] Embodiment 74. The syringe of any one of embodiments 59-73, wherein the syringe is a pre-filled syringe comprising an active pharmaceutical ingredient (API).

[0227] Embodiment 75. A method of injecting an active pharmaceutical ingredient (API) contained in a syringe, comprising: inserting a needle of the syringe into an injection site, the syringe comprising: a plunger comprising a plunger stopper at a distal end of the plunger and a plunger rod extending from the plunger stopper; and a single monolithic housing, comprising: a barrel that receives the plunger rod; one or more flanges at a proximal end of the barrel; and a base portion at a distal end of the barrel that extends outward in at least one direction from an outer surface of the barrel toward an end of the base portion that provides a stable contact surface on the injection site; and injecting the API at the injection site at a depth of the needle limited by the single monolithic housing.

[0228] Embodiment 76. The method of embodiment 75, wherein inserting the needle into the injection site comprises advancing the needle into the injection site until the end of the base portion providing the stable contact surface contacts the injection site.

[0229] Embodiment 77. The method of embodiment 75 or 76, wherein the base portion raises a portion of skin at the injection site that is within a perimeter of the base portion when the base portion contacts the injection site.

[0230] Embodiment 78. The method of any one of embodiments 75-77, wherein, during injection of the API at the injection site, the single monolithic housing provides an injection angle relative to the contact surface that is between 85 degrees and 95 degrees.

[0231] Embodiment 79. The method of any one of embodiments 75-78, wherein the barrel has a volume capacity between 0.1 mL and 70 mL.

[0232] Embodiment 80. The method of any one of embodiments 75-79, wherein the syringe is a 3-mL syringe or a 5-mL syringe.

[0233] Embodiment 81. The method of any one of embodiments 75-80, wherein, during injection of the API at the injection site, the single monolithic housing limits the depth of the needle to between 4 mm and 12 mm.

[0234] Embodiment 82. The method of any one of embodiments 75-81, wherein the single monolithic housing limits the depth of the needle to a subcutaneous layer of skin and / or to an intramuscular injection.

[0235] Embodiment 83. The method of any one of embodiments 75-82, wherein the single monolithic housing limits protrusion of the needle of the syringe when the needle is not yet inserted into the injection site.

[0236] Embodiment 84. The method of any one of embodiments 75-83, wherein the syringe is pre-loaded with the API.

[0237] Embodiment 85. The method of any one of embodiments 75-84, comprising loading the syringe with the API

[0238] Embodiment 86. The method of any one of embodiments 75-85, wherein, prior to use, the needle is protected by a removable cap, and the method comprises removing the cap from the needle.

[0239] Embodiment 87. The syringe accessory of any one of embodiments 1-25, comprising a locking member disposed at the proximal end of the tubular portion and configured to retain the syringe within the tubular portion.

[0240] Embodiment 88. The syringe accessory of any one of embodiments 1-25, wherein the tubular portion comprises an opening extending a length of the tubular portion and configured to receive the syringe, and the syringe accessory comprises one or more retaining members disposed at a proximal end of the opening and configured to retain the syringe within the tubular portion.

[0241] Embodiment 89. The syringe accessory of any one of embodiments 1-25, wherein the tubular portion comprises an opening extending a length of the tubular portion and configured to receive the syringe, and the syringe accessory comprises a door disposed along at least a portion of the length of the opening and configured to retain the syringe within the tubular portion.

[0242] Embodiment 90. The syringe accessory of any one of embodiments 1-25, 88, and 89, comprising a slot disposed at the proximal end of the tubular portion and configured to receive the one or more flanges of the syringe.

Claims

CLAIMSWhat is claimed is:

1. A syringe accessory, comprising: a single monolithic housing comprising: a tubular portion configured to receive a barrel of a syringe; one or more flanges at a proximal end of the tubular portion; and a base portion at a distal end of the tubular portion that extends outward in at least one direction from an outer surface of the tubular portion toward an end of the base portion that is configured to provide a stable contact surface on an injection site, wherein the single monolithic housing is configured to limit protrusion of a needle of a syringe when the barrel of the syringe is received in the tubular portion.

2. The syringe accessory of claim 1 , wherein the base portion comprises a cross-sectional dimension that is larger than a cross-sectional dimension of the tubular portion.

3. The syringe accessory of claim 1 or 2, wherein the base portion is configured to raise a portion of skin at the injection site that is within a perimeter of the base portion when the base portion contacts the injection site.

4. The syringe accessory of any one of claims 1-3, wherein the single monolithic housing is configured to provide an injection angle relative to the contact surface between 85 degrees and 95 degrees.

5. The syringe accessory of any one of claims 1-4, wherein the single monolithic housing comprises one or more latches are disposed at the proximal end of the tubular portion and configured to clip the syringe barrel when the syringe barrel is advanced distally passed the one or more latches to prevent retraction of the syringe from the single monolithic housing.

6. The syringe accessory of any one of claims 1-5, wherein the syringe accessory is the single monolithic housing.

7. The syringe accessory of any one of claims 1-6, wherein the tubular portion comprises a constriction along a length of the tubular portion between a proximal portion and a distal portion of the tubular portion that is configured to limit the protrusion of the needle from the distal portion when the barrel of the syringe is received in the proximal portion of the tubular portion.

8. The syringe accessory of any one of claims 1-7, wherein the one or more flanges at the proximal end of the tubular portion are larger than one or more flanges of the syringe.

9. A syringe assembly, comprising: the syringe accessory of any one of claims 1-8; and a syringe.

10. The syringe assembly of claim 9, wherein the syringe is a pre-filled syringe comprising an active pharmaceutical ingredient (API).

11. A method of assembling a syringe and a syringe accessory, comprising: inserting a barrel of the syringe into a proximal end of a tubular portion of the syringe accessory; and advancing the barrel toward a distal end of the tubular portion until one or more flanges of the syringe clips on one or more latches on an inner surface of the syringe accessory, wherein the syringe accessory comprises a single monolithic housing comprising the tubular portion, one or more flanges at the proximal end of the tubular portion, and a base portion at the distal end of the tubular portion that extends outward in at least one direction from an outer surface of the tubular portion toward an end of the base portion to provide a stable contact surface on an injection site.

12. The method of claim 11, wherein the one or more latches are disposed at the proximal end of the tubular portion of the single monolithic housing such that the one or more latches prevent retraction of the syringe from the syringe accessory when the syringe barrel is advanced distally passed the one or more latches.

13. The method of claim 11 or 12, wherein the tubular portion comprises a constriction along a length of the tubular portion between a proximal portion and a distal portion of the tubular portion to limit protrusion of the needle from the distal portion when the barrel of the syringe is inserted into the proximal portion of the tubular portion.

14. A syringe, comprising: a plunger comprising a plunger stopper at a distal end of the plunger and a plunger rod extending from the plunger stopper; and a single monolithic housing, comprising: a barrel configured to receive the plunger rod; one or more flanges at a proximal end of the barrel; and a base portion at a distal end of the barrel that extends outward in at least one direction from an outer surface of the barrel toward an end of the base portion that is configured to provide a stable contact surface on an injection site, wherein the single monolithic housing is configured to limit protrusion of a needle when the needle is coupled to the distal end of the barrel.

15. The syringe of claim 14, wherein the base portion is configured to raise a portion of skin at the injection site that is within a perimeter of the base portion when the base portion contacts the injection site.

16. The syringe of claim 14 or 15, wherein the single monolithic housing is configured to provide an injection angle relative to the contact surface between 85 degrees and 95 degrees.

17. The syringe of any one of claims 14-16, wherein the syringe consists of the plunger and the single monolithic housing.

18. The syringe of any one of claims 14-17, wherein the syringe is a pre-filled syringe comprising an active pharmaceutical ingredient (API).

19. The syringe accessory of any one of claims 1-8, comprising a locking member disposed at the proximal end of the tubular portion and configured to retain the syringe within the tubular portion.

20. The syringe accessory of any one of claims 1-8, wherein the tubular portion comprises an opening extending a length of the tubular portion and configured to receive the syringe, and the syringe accessory comprises one or more retaining members disposed at a proximal end of the opening and configured to retain the syringe within the tubular portion.

21. The syringe accessory of any one of claims 1-8, wherein the tubular portion comprises an opening extending a length of the tubular portion and configured to receive the syringe, and the syringe accessory comprises a door disposed along at least a portion of the length of the opening and configured to retain the syringe within the tubular portion.

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