Cosmetic composition comprising 2,4-diaminopyrimidine-3-N-oxide, piroctone olamine, caffeine, and an extract of Eperua falcata bark

Abstract

The present invention relates to a cosmetic composition comprising 2,4-diaminopyrimidine-3-N-oxide and / or one of its organic or mineral acid salts and / or one of its hydrates, piroctone olamine, caffeine, and an extract of Eperua falcata bark. The invention also relates to a method for the cosmetic treatment of human keratin materials such as the skin, in particular the scalp, human hair and / or eyelashes, comprising at least the application of the cosmetic composition according to the present invention. The present invention also relates to the use of said cosmetic composition for treating hair loss, and / or promoting the regrowth of keratin fibers.

Description

Title of the invention: Cosmetic composition comprising 2,4-diaminopyrimidine-3-N-oxide, piroctone olamine, caffeine, and an extract of Eperua falcata bark

[0001] The present invention relates to a cosmetic composition comprising 2,4-diaminopyrimidine-3-N-oxide and / or one of its organic or mineral acid salts and / or one of its hydrates, piroctone olamine, caffeine, and an extract of Eperua falcata bark.

[0002] The invention also relates to a method for the cosmetic treatment of human keratin materials such as the skin, in particular the scalp, hair and / or human eyelashes, comprising at least the application of the cosmetic composition according to the present invention.

[0003] The present invention also relates to the use of said cosmetic composition for treating hair loss, and / or promoting the regrowth of keratin fibers.

[0004] The present invention relates to the field of cosmetic treatment of human keratin materials, in particular human keratin fibers, such as human hair, eyebrows, eyelashes and / or body hair, in particular beard hair, mustache hair and pubic hair, and skin, in particular the scalp and areas of skin, in particular alopecic or non-alopecic areas, preferably alopecic, covered with keratin fibers as mentioned above. More particularly, the invention relates to the cosmetic treatment of human hair and / or eyelashes and / or skin, preferably hair and / or scalp.

[0005] Hair growth and renewal in humans are mainly determined by the activity of hair follicles and their dermo-epidermal environment. Their activity is cyclical and essentially comprises three phases, namely the anagen phase, the catagen phase and the telogen phase.

[0006] The anagen phase (corresponding to the active phase or growth phase), which lasts several years and during which the hair grows, is followed by a very short and transient catagen phase which lasts a few weeks. During this phase, the hair undergoes an evolution, the follicle atrophies and its dermal implantation appears higher and higher.

[0007] The terminal phase, which lasts a few months, corresponds to a resting phase, called the telogen phase. At the end of this resting period, the hair falls out and gives way to new hair follicles in the anagen phase so that another hair cycle begins again.

[0008] The hair is therefore constantly renewed, and of the approximately 150,000 hairs that a head of hair contains, at any given moment, approximately 10% of them are at rest and will therefore be replaced within a few months.

[0009] Alopecia refers to the accelerated loss of hair, eyelashes, eyebrows and / or body hair from any part of the body. It generally occurs in genetically predisposed individuals and mainly affects men. This is called androgenetic or androgenic alopecia or androgen-genetic alopecia.

[0010] Alopecia is essentially due to a disruption in hair renewal which initially leads to an acceleration in the frequency of cycles at the expense of hair quality and then quantity. This results in a progressive depletion of the hair by regression of so-called "terminal" hair to the downy hair stage. Certain areas are preferentially affected; in particular in men, the temporal or frontal gulfs as well as the upper part of the occipital, while in women, there is more diffuse alopecia of the vertex.

[0011] Other causes can lead to significant, temporary or permanent hair loss. This can include hair loss and alteration after pregnancy (or postpartum), during states of malnutrition or dietary imbalances, or even states of asthenia or hormonal dysfunction, as can be the case during or after menopause. It can also be hair loss or alteration related to seasonal phenomena.

[0012] Alopecia can also affect eyelashes, eyebrows and / or hair on any part of the human body and can cause aesthetic discomfort in the same way as alopecia affecting one or more areas of the scalp.

[0013] People thus subject to alopecia are increasingly resorting to cosmetic treatments making it possible to eliminate and / or reduce the effect of alopecia, and in particular to reduce or delay the loss of hair, eyelashes and / or body hair, as well as to induce or stimulate their growth.

[0014] Such treatments generally consist of daily applications to the various alopecic areas of the human body, in particular to the alopecic areas of the scalp, such as the temporal or frontal gulfs in men, or to areas of the body devoid of hair, in particular on the face, in particular the beard, moustache and / or eyebrows, of cosmetic compositions comprising one or more anti-hair loss agents and / or agents capable of promoting regrowth.

[0015] For this purpose, mention may in particular be made, as agents capable of reducing hair loss and / or promoting the regrowth of keratin fibres, of agents such as minoxidil, finasteride, aminexil or even stemoxydine.

[0016] The duration of these treatments generally varies from several weeks to several months, or can even extend over years, and their long-term effectiveness most often depends on the assiduity observed by the user in regularly applying the com- cosmetic positions on the areas to be treated which may be more or less extensive.

[0017] The implementation of treatments capable of reducing hair loss and / or promoting the regrowth of hair, eyelashes and / or body hair, can in particular last several weeks before the desired effects can begin to be seen, in particular slowing down alopecia.

[0018] The use of these treatments must be daily to obtain pronounced effectiveness.

[0019] However, these compositions still too often present numerous disadvantages of use which can have a negative impact on the cosmetic treatment to be followed, which may in particular lead to a more or less rapid abandonment of the treatment and, consequently, to poor results in terms of limitation, or even elimination of alopecia.

[0020] Indeed, many compositions include gelling agents in order to prevent the composition from running onto the face, into the eyes or down the neck. However, the use of gelling agents, particularly in the context of daily use, leads to aggregation of the keratin fibers, providing a sticky effect on the hair which is not acceptable to consumers.

[0021] In order to improve the effectiveness of these treatments, it may be necessary to increase the quantities of active ingredients, which can lead to difficulties in solubilizing the active ingredients and, during use, cause the formation of visible powders on the keratin fibers and on the scalp. This powdery effect is also not acceptable to consumers. The use of anti-hair loss lotions must be daily to obtain pronounced effectiveness. Some consumers wash their hair every day, and in this case, the products previously applied to the scalp are eliminated. Most consumers do not wash their hair every day, so the product applied on the second day is added to the product applied on the first day. This is called a cumulative effect. In this context of repeated application without washing the scalp, the appearance of powder can be present from the first day, and more often present on the second day.This appearance of powder results from the precipitation of the solid compounds of the formula, during the evaporation of the solvent.

[0022] As a result, the insufficient qualities of use of these compositions may in the long run discourage users from diligently following cosmetic treatments for hair loss and / or regrowth, especially since the effectiveness of these treatments is mainly linked to the daily regularity of the implementation of the compositions described above on the areas to be treated for several weeks, or even several months.

[0023] In other words, a lack of assiduity or abandoning treatment too quickly most of the time leads to poor results in terms of anti-hair loss effectiveness and / or regrowth and, consequently, to dissatisfaction. This reinforces disappointment in consumers who do not have the time to observe the progress and / or long-term effectiveness of these treatments.

[0024] There is therefore a real need to overcome the drawbacks mentioned above, in particular by implementing a composition capable of cosmetically and effectively treating the loss of human keratin fibers such as human hair, body hair and / or eyelashes, and / or of promoting their regrowth, having improved qualities of use while ensuring in particular a satisfactory visual rendering, in particular without a greasy effect and without residue. This composition must also allow repeated application, that is to say allow daily use of the composition.

[0025] This aim is achieved by the present invention which in particular relates to a cosmetic composition comprising: (i) 2,4-diaminopyrimidine-3-N-oxide and / or one of its organic or mineral acid salts and / or one of its hydrates, (ii) piroctone olamine, (iii) caffeine, and iv) an extract of Eperua falcata bark.

[0026] The cosmetic composition according to the invention has improved qualities of use by making it possible to avoid the powdery effect and / or aggregation of keratin fibers, in particular in the context of repeated application required by frequent use.

[0027] The cosmetic composition according to the invention also gives complete satisfaction in terms of anti-hair loss effectiveness and / or regrowth of keratin fibers. It also has a beneficial effect on increasing the diameter of keratin fibers and on strengthening the fibers against breakage.

[0028] In addition, the composition according to the invention makes it possible to provide keratin fibers with good cosmetic properties, in particular conditioning properties, particularly in terms of flexibility, looseness, and smoothness to the touch. It also allows for easy detangling.

[0029] The invention also relates to a method for the cosmetic treatment of human keratin materials such as the skin, in particular the scalp, hair and / or human eyelashes, comprising at least the application of the cosmetic composition according to the present invention.

[0030] The present invention also relates to the use of said cosmetic composition for treating hair loss, and / or promoting the regrowth of keratin fibers.

[0031] The present invention also relates to the use of said cosmetic composition for increasing the diameter of keratin fibers and / or strengthening keratin fibers against breakage.

[0032] Other objects, characteristics, aspects and advantages of the invention will become apparent even more clearly when reading the description and the example that follows.

[0033] In what follows, and unless otherwise indicated, the limits of a domain of values ​​are included in this domain, in particular in the expressions “between” and “ranging from ... to ...”.

[0034] Furthermore, the expression “at least one” used in the present description is equivalent to the expression “one or more”.

[0035] i) 2A-diaminovyrimidine-3-N-oxide The cosmetic composition according to the invention comprises 2,4-diaminopyrimidine-3-N-oxide and / or one of its organic or mineral acid salts and / or one of its hydrates.

[0036] 2,4-Diaminopyrimidine-3-N-oxide has the following formula:

[0037] Among the organic or mineral acid salts that can be used, mention may be made in particular of hydrochlorides, sulfates, citrates and acetates. As hydrate, mention may be made in particular of monohydrate.

[0038] Preferably, the non-salified compound is used in monohydrate form.

[0039] Preferably, the total content of 2,4-diaminopyrimidine-3-N-oxide and / or one of its organic or mineral acid salts and / or one of its hydrates ranges from 0.05 to 8% by weight, better still from 0.1 to 5%, even better still from 0.2 to 4%, then from 0.5 to 3%, and preferentially from 1 to 2% by weight, relative to the total weight of the composition.

[0040] Preferably, the content of 2,4-diaminopyrimidine-3-N-oxide and / or one of its hydrates, in particular monohydrate, ranges from 0.05 to 8% by weight, better still from 0.1 to 5%, even better still from 0.2 to 4%, from 0.5 to 3% and preferentially from 1 to 2% by weight, relative to the total weight of the composition.

[0041] ii) Piroctone Olamine The cosmetic composition according to the invention also comprises piroctone olamine.

[0042] Piroctone olamine is a monoethanolamine salt of l-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(lH)-pyridinone.

[0043] Preferably, the total content of piroctone olamine ranges from 0.05 to 2% by weight, better still from 0.1 to 1%, preferentially from 0.1 to 0.5% by weight, relative to the total weight of the composition.

[0044] zzz) Caffeine The cosmetic composition according to the invention further comprises caffeine.

[0045] Preferably, the total caffeine content ranges from 0.1 to 10%, better still 0.5 to 5%, better still 1 to 4% by weight, and preferably from 1.5 to 3% by weight, relative to the total weight of the composition.

[0046] iv) Eperua falcata bark extract The cosmetic composition according to the invention further comprises an extract of Eperua falcata bark (INCI name: EPERUA FALCATA BARK EXTRACT).

[0047] The Eperua falcata bark extract is preferably an aqueous extract obtained from ground bark. It can be absorbed onto a neutral carrier such as dextrin to produce a powder upon drying.

[0048] An extract of Eperua falcata bark which can be used according to the invention is in particular that marketed under the name Eperuline® (PW LS 9627 by the company BASF).

[0049] The total content of Eperua falcata bark extract preferably ranges from 0.02 to 0.2% by weight, more preferably from 0.05 to 0.1% by weight, relative to the total weight of the composition.

[0050] v) Hydroxylated compounds The cosmetic composition according to the invention may optionally also comprise one or more hydroxylated compounds v) having a melting temperature of less than 25°C at atmospheric pressure (1,013.105 Pa) (eg they are liquid at 25°C and atmospheric pressure) and a boiling temperature of greater than or equal to 170°C.

[0051] Preferably, said hydroxylated compounds consist of a C2-C8 hydrocarbon chain optionally interrupted by an oxygen atom and comprising from 1 to 2 free hydroxylated groups (-OH) carried by different carbon atoms.

[0052] These compounds can be cyclic or acyclic, linear or branched, saturated or unsaturated.

[0053] Preferably, the hydroxylated compound(s) are chosen from linear C2-C8, better C2-C6, diols, or aromatic C6-C8, better C7-C8 monoalcohols, and mixtures thereof. More preferably, the hydroxylated compound(s) are chosen from linear C2-C8, better C2-C6, diols.

[0054] Mention may in particular be made of propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, propane-1,3 diol, benzyl alcohol, phenethyl alcohol (phenylethyl alcohol), dipropylene glycol.

[0055] More preferably still, the hydroxylated compound v) is propylene glycol.

[0056] The total content of hydroxylated compounds v), when they are present in the composition according to the invention, is greater than or equal to 0.5% by weight, relative to the total weight of the composition, preferably greater than or equal to 1% by weight, by relative to the total weight of the composition.

[0057] Preferably, the total content of hydroxylated compounds, when they are present in the composition according to the invention, ranges from 0.5 to 15% by weight, better still from 1 to 10%, more preferably from 1.5 to 8% by weight, even more preferably from 2 to 6% by weight, relative to the total weight of the composition.

[0058] Preferably, the total content of hydroxylated compounds chosen from linear C2-C8 diols is greater than or equal to 0.5% by weight, better still ranging from 0.5 to 15%, preferably ranging from 1 to 10% by weight, more preferably from 1.5 to 8% by weight, even more preferably from 2 to 6% by weight, or even from 2 to 4% by weight relative to the total weight of the composition.

[0059] Preferably, the total propylene glycol content is greater than or equal to 0.5% by weight, better still ranging from 0.5 to 15%, preferably ranging from 1 to 10% by weight, more preferably from 1.5 to 8% by weight, even more preferably from 2 to 6% by weight, or even from 2 to 4% by weight relative to the total weight of the composition.

[0060] vi) Extract of yeasts of the genus Pichia minuta The cosmetic composition according to the invention may optionally also comprise an extract of yeasts of the genus Pichia minuta.

[0061] Yeast of the genus Pichia minuta means any yeast of the Saccharo-mycetaceae family, of the genus Ogataea and of the species Pichia minuta. Pichia minuta can in particular be isolated from the flower of the azalea Rhododendron indicum.

[0062] The yeast extract of the genus Pichia minuta is preferably in the form of a hydrolyzate. Such an extract is notably described in patent application FR3061656.

[0063] A yeast extract of the genus Pichia minuta which can be used according to the invention is notably marketed under the name Hairgenyl® by the company Silab.

[0064] When present in the composition according to the invention, the total content of yeast extract of the genus Pichia minuta preferably ranges from 0.02 to 0.2% by weight, more preferably from 0.03 to 0.1% by weight, relative to the total weight of the composition.

[0065] vii} Thickening polymers The composition according to the invention may optionally comprise one or more thickening polymers.

[0066] By "thickening polymer" is meant according to the present invention polymers which increase, by their presence at a concentration of 0.05% by weight, the viscosity of the cosmetic compositions into which they are introduced by at least 20 cps (20 mPa.s), preferably by at least 50 cps (50 mPa.s), at room temperature (25°C), at atmospheric pressure and at a shear rate of 1s 1 (the viscosity can be measured using a cone / plate viscometer, Haake R600 Rheometer or the like).

[0067] The thickening polymer(s) that can be used in the process according to the invention are

[0068]

[0069]

[0070]

[0071]

[0072]

[0073]

[0074]

[0075]

[0076] preferentially chosen from non-associative thickening polymers with sugar units, non-associative thickening polymers without sugar unit, associative thickening polymers, and mixtures thereof. For the purposes of the present invention, the term “sugar unit” means an oxygenated hydrocarbon compound which has several alcohol functions, with or without aldehyde or ketone functions, and which comprises at least 4 carbon atoms. The sugar units can be optionally modified by substitution, and / or by oxidation and / or by dehydration. The sugar units of the thickening polymers are preferably derived from the following sugars: glucose; galactose; arabinose; rhamnose; mannose; xylose; fucose; anhydrogalactose; galacturonic acid; glucuronic acid; mannuronic acid; galactose sulfate; anhydrogalactose sulfate and fructose. According to the invention, polymers with sugar units are also called polysaccharides. Examples of non-associative thickening polymers with sugar units include native gums such as: (a) exudates from trees or shrubs including: - gum arabic (branched polymer of galactose, arabinose, rhamnose and glucuronic acid); - gum ghatti (polymer from arabinose, galactose, mannose, xylose and glucuronic acid); - karaya gum (polymer from galacturonic acid, galactose, rhamnose and glucuronic acid); - gum tragacanth (or tragacanth) (polymer of galacturonic acid, galactose, fucose, xylose and arabinose); b) gums derived from algae including: - agar (polymer derived from galactose and anhydrogalactose); - alginates (polymers of mannuronic acid and glucuronic acid); - carrageenans and furcellerans (polymers of galactose sulfate and anhydrogalactose sulfate); (c) gums from seeds or tubers of which: - guar gum (polymer of mannose and galactose); - carob gum (polymer of mannose and galactose); - fenugreek gum (polymer of mannose and galactose); - tamarind gum (polymer of galactose, xylose and glucose); - konjac gum (polymer of glucose and mannose); (d) microbial gums including: - xanthan gum (polymer of glucose, mannose acetate, mannose / pyruvic acid and glucuronic acid); gellan gum (polymer of partially acylated glucose, rhamnose and glucuronic acid); scleroglucan gum (polymer of glucose);

[0077] e) plant extracts including: cellulose (polymer of glucose); starch (polymer of glucose) and inulin.

[0078] These polymers can be modified physically or chemically. Physical treatment includes, in particular, temperature.

[0079] As chemical treatments, mention may be made of esterification, etherification, amidation and oxidation reactions. These treatments make it possible to produce polymers which may in particular be non-ionic, anionic or amphoteric.

[0080] Preferably, these chemical or physical treatments are applied to guar gums, locust bean gums, starches and celluloses.

[0081] The non-ionic guar gums that can be used according to the invention can be modified by C1-C6 (poly)hydroxyalkyl groups.

[0082] Among the (poly)hydroxyalkyl groups in C1-C6, mention may be made, by way of example, of the hydroxymethyl, hydroxyethyl, hydroxypropyl and hydroxybutyl groups.

[0083] These guar gums are well known in the state of the art and can, for example, be prepared by reacting corresponding alkene oxides such as, for example, propylene oxides with guar gum so as to obtain a guar gum modified by hydroxypropyl groups.

[0084] The hydroxyalkylation rate preferably varies from 0.4 to 1.2 and corresponds to the number of alkylene oxide molecules consumed by the number of free hydroxyl functions present on the guar gum.

[0085] Such non-ionic guar gums, optionally modified by hydroxyalkyl groups, are for example sold under the trade names JAGUAR HP8, JAGUAR HP60 and JAGUAR HP120 by the company RHODIA CHIMIE.

[0086] The starch molecules that can be used in the present invention may have cereals or tubers as their botanical origin. Thus, the starches are, for example, chosen from corn, rice, cassava, barley, potato, wheat, sorghum and pea starches.

[0087] Starches can be modified chemically or physically: in particular by one or more of the following reactions: pregelatinization, oxidation, crosslinking, esterification, etherification, amidation, heat treatments.

[0088] Distarch phosphates or compounds rich in distarch phosphate will preferably be used, such as the product offered under the references PREJEL VA-70-T AGGL (gelatinized hydroxypropyl cassava distarch phosphate) or PREJEL TK1 (gelatinized cassava distarch phosphate) or PREJEL 200 (gelatinized acetylated cassava distarch phosphate) by the company AVEBE or STRUCTURE ZEA from NATIONAL STARCH (gelatinized corn distarch phosphate).

[0089] According to the invention, amphoteric starches can also be used, these amphoteric starches comprise one or more anionic groups and one or more cationic groups. The anionic and cationic groups can be linked to the same reactive site of the starch molecule or to different reactive sites; preferably they are linked to the same reactive site. The anionic groups can be of the carboxylic, phosphate or sulfate type and preferably carboxylic. The cationic groups can be of the primary, secondary, tertiary or quaternary amine type.

[0090] The starch molecules can be derived from all plant sources of starch such as corn, potato, oats, rice, tapioca, sorghum, barley or wheat. Hydrolysates of the starches mentioned above can also be used. The starch is preferably derived from potato.

[0091] The non-associative thickening polymers of the invention may be cellulosic polymers not comprising a Cio-C3o fatty chain in their structure.

[0092] According to the invention, the term “cellulosic” polymer means any polysaccharide compound having in its structure chains of glucose residues joined by [3-1,4] bonds; in addition to unsubstituted celluloses, cellulose derivatives can be anionic, cationic, amphoteric or non-ionic.

[0093] Thus, the cellulose polymers which can be used according to the invention can be chosen from unsubstituted celluloses including in microcrystalline form and cellulose ethers.

[0094] Among these cellulose polymers, we distinguish cellulose ethers, cellulose esters and cellulose ether esters.

[0095] Among the cellulose esters, there are inorganic cellulose esters (nitrates, sulfates or phosphates of cellulose...), organic cellulose esters (monoacetates, triacetates, amidopropionates, acetatebutyrates, acetatepropionates or acetatetrimellitates of cellulose...) and mixed organic / inorganic cellulose esters such as cellulose acetatebutyratesulfates and acetatepropionatesulfates. Among the cellulose ether esters, there are hydroxypropylmethylcellulose phthalates and ethylcellulose sulfates.

[0096] Among the non-ionic cellulose ethers without a Cio-C3o fatty chain, i.e. “non-associative”, mention may be made of (Ci-C4)alkylcelluloses such as methylcelluloses and ethylcelluloses (for example Ethocel standard 100 Premium from DOW CHEMICAL); (poly)hydroxy(Ci-C4)alkylcelluloses such as hydroxymethylcelluloses, hydroxyethylcelluloses (for example Natrosol 250 HHR offered by AQUALON) and hydroxypropylcelluloses (for example Klucel EF from AQUALON); mixed celluloses (poly)hydroxy(Ci-C4)alkyl-(Ci-C4)alkylcelluloses such as hydroxypropyl-methylcelluloses (e.g. Methocel E4M from DOW CHEMICAL), hydroxyethyl-methylcelluloses, hydroxyethyl-ethylcelluloses (e.g. Bermocoll E 481 FQ from AKZO NOBEL) and hydroxybutyl-methylcelluloses.

[0097] Among the anionic cellulose ethers without fatty chain, mention may be made of (poly)carboxy(Ci-C4)alkylcelluloses and their salts. By way of example, mention may be made of carboxymethylcelluloses, carboxymethylmethylcelluloses (for example Blanose 7M from the company AQUALON) and carboxymethylhydroxyethylcelluloses and their sodium salts.

[0098] Among the cationic cellulose ethers without fatty chain, mention may be made of cationic cellulose derivatives such as cellulose copolymers or cellulose derivatives grafted with a water-soluble quaternary ammonium monomer, and described in particular in US patent 4,131,576, such as (poly)hydroxy(Ci-C4)alkyl celluloses, such as hydroxymethyl-, hydroxyethyl- or hydroxypropyl celluloses grafted in particular with a salt of methacryloylethyl trimethylammonium, methacrylmidopropyl trimethylammonium, dimethyl-diallylammonium. The marketed products meeting this definition are more particularly the products sold under the name "Celquat® L 200" and "Celquat® H 100" by the National Starch Company.

[0099] Among the non-associative thickening polymers without sugar units which can be used according to the invention, mention may be made of crosslinked homopolymers or copolymers of acrylic or methacrylic acid, crosslinked homopolymers of 2-acrylamido-2-methyl-propanesulfonic acid and their crosslinked acrylamide copolymers, homopolymers of ammonium acrylate or copolymers of ammonium acrylate and acrylamide alone or as mixtures.

[0100] A first family of suitable non-associative thickening polymers is represented by crosslinked acrylic acid homopolymers.

[0101] Among the homopolymers of this type, mention may be made of those crosslinked by an allyl ether of alcohol from the sugar series, such as for example the products sold under the names CARBOPOLS 980, 981, 954, 2984 and 5984 by the company NOVEON or the products sold under the names SYNTHALEN M and SYNTHALEN K by the company 3 VS A. These polymers have the INCI name Carbomer.

[0102] The non-associative thickening polymers can also be crosslinked (meth)acrylic acid copolymers such as the polymer sold under the name AQUA SF1 by the company NOVEON.

[0103] The non-associative thickening polymers may be chosen from crosslinked homopolymers of 2-acrylamido-2-methylpropane sulfonic acid and their crosslinked acrylamide copolymers.

[0104] Among the crosslinked copolymers of 2-acrylamido-2-methyl-propanesulfonic acid and partially or totally neutralized acrylamide, mention may be made in particular of the product described in example 1 of document EP 503 853 and reference may be made to this document with regard to these polymers.

[0105] The composition according to the invention may also comprise, as non-associative thickening polymers, ammonium acrylate homopolymers or ammonium acrylate and acrylamide copolymers.

[0106] As examples of ammonium acrylate homopolymers, mention may be made of the product sold under the name MICROS AP PAS 5193 by the company HOECHST. Among the copolymers of ammonium acrylate and acrylamide, mention may be made of the product sold under the name BOZEPOL C NOUVEAU or the product PAS 5193 sold by the company HOECHST. Reference may in particular be made to documents FR 2 416 723, US 2798053 and US 2923692 with regard to the description and preparation of such compounds.

[0107] Cationic thickening polymers of the acrylic type can also be used.

[0108] Among the thickening polymers, mention may also be made of associative polymers well known to those skilled in the art and in particular of a non-ionic, anionic, cationic or amphoteric nature, preferably anionic.

[0109] It is recalled that “associative polymers” are polymers capable, in an aqueous medium, of reversibly associating with each other or with other molecules.

[0110] Their chemical structure more particularly comprises at least one hydrophilic zone and at least one hydrophobic zone.

[0111] By “hydrophobic group” is meant a radical or polymer with a hydrocarbon chain, saturated or unsaturated, linear or branched, comprising at least 10 carbon atoms, preferably from 10 to 30 carbon atoms, in particular from 12 to 30 carbon atoms and more preferably from 18 to 30 carbon atoms.

[0112] Preferably, the hydrocarbon group originates from a monofunctional compound. For example, the hydrophobic group may originate from a fatty alcohol such as stearyl alcohol, dodecyl alcohol, decyl alcohol. It may also designate a hydrocarbon polymer such as, for example, polybutadiene.

[0113] Among the associative polymers of anionic type, we can cite:

[0114] - (a) those comprising at least one hydrophilic unit, and at least one ether unit of fatty chain allyl, more particularly those whose hydrophilic unit is constituted by an ethylenically unsaturated anionic monomer, more particularly still by a vinyl carboxylic acid and very particularly by an acrylic acid or a methacrylic acid or mixtures thereof.

[0115] Among these anionic associative polymers, polymers formed from 20 to 60% by weight of acrylic acid and / or methacrylic acid, from 5 to 60% by weight of lower alkyl (meth)acrylates, from 2 to 50% by weight of fatty chain allyl ether, and from 0 to 1% by weight of a crosslinking agent which is a well-known copolymerizable polyethylene unsaturated monomer, such as diallyl phthalate, allyl (meth)acrylate, divinylbenzene, (poly)ethylene glycol dimethacrylate, and methylene-bis-acrylamide are particularly preferred according to the invention.

[0116] Among the latter, particularly preferred are crosslinked terpolymers of methacrylic acid, ethyl acrylate, polyethylene glycol (10 EO) stearyl alcohol ether (Steareth 10), in particular those sold by the company CIBA under the names SALCARE SC80® and SALCARE SC90® which are 30% aqueous emulsions of a crosslinked terpolymer of methacrylic acid, ethyl acrylate and steareth-10-allyl ether (40 / 50 / 10).

[0117] - (b) those comprising i) at least one hydrophilic unit of carboxylic acid type unsaturated olefinic acid, and ii) at least one hydrophobic unit of the unsaturated carboxylic acid (Ci0-C30) alkyl ester type.

[0118] Alkyl esters (Ci0-C30) of unsaturated carboxylic acids useful in the invention include, for example, lauryl acrylate, stearyl acrylate, decyl acrylate, isodecyl acrylate, dodecyl acrylate, and the corresponding methacrylates, lauryl methacrylate, stearyl methacrylate, decyl methacrylate, isodecyl methacrylate, and dodecyl methacrylate.

[0119] Anionic polymers of this type are for example described and prepared, according to US patents 3,915,921 and 4,509,949.

[0120] Among this type of anionic associative polymers, those consisting of 60 to 95% by weight of acrylic acid (hydrophilic unit), 4 to 40% by weight of Cio-C3o alkyl acrylate (hydrophobic unit), and 0 to 6% by weight of crosslinking polymerizable monomer, or those consisting of 96 to 98% by weight of acrylic acid (hydrophilic unit), 1 to 4% by weight of Cio-C3o alkyl acrylate (hydrophobic unit), and 0.1 to 0.6% by weight of crosslinking polymerizable monomer such as those described above, will be used more particularly.

[0121] Among the above polymers, the products sold by the company GOODRICH under the trade names PEMULEN TRI®, PEMULEN TR2®, CARBOPOL 1382®, and even more preferably PEMULEN TRI®, and the product sold by the company SEPPIC are particularly preferred according to the present invention. under the name COATEX SX®.

[0122] Mention may also be made of the acrylic acid / lauryl methacrylate / vinylpyrrolidone terpolymer marketed under the name Acrylidone LM by the ISP Company.

[0123] - (c) maleic anhydride / C30-C38 α-olefin / alkyl maleate terpolymers such as that the product (maleic anhydride / C30-C38 a-olefin / isopropyl maleate copolymer) sold under the name PERFORMA V 1608® by the company NEWPHASE TECHNOLOGIES.

[0124] - (d) acrylic terpolymers comprising:

[0125] i) about 20 to 70% by weight of an α,[3-monoethylenically unsaturated carboxylic acid [A],

[0126] ii) about 20 to 80% by weight of a non-surfactant α,[3-monoethylenic] unsaturated monomer different from [A],

[0127] iii) about 0.5 to 60% by weight of a non-ionic mono-urethane which is the reaction product of a monohydric surfactant with a monoethylenically unsaturated monoisocyanate,

[0128] such as those described in patent application EP-A-0173109 and more particularly that described in example 3, namely, a methacrylic acid / methyl acrylate / ethoxylated behenyl alcohol dimethyl metaisopropenyl benzyl isocyanate terpolymer (40EO) in 25% aqueous dispersion.

[0129] - (e) copolymers comprising among their monomers a carboxylic acid with α,[3-monoethylenic saturation and an α,[3-monoethylenic unsaturated carboxylic acid ester of an oxyalkylenated fatty alcohol.

[0130] Preferably, these compounds also comprise as monomer an ester of carboxylic acid with α,[3-monoethylenic unsaturation and of C1-C4 alcohol.

[0131] As an example of this type of compound, mention may be made of ACULYN 22® sold by the company ROHM and HAAS, which is a methacrylic acid / ethyl acrylate / oxyalkylenated stearyl methacrylate terpolymer, as well as ACULYN 88 also sold by the company ROHM and HAAS.

[0132] - (f) Amphiphilic polymers comprising at least one unsaturated monomer ethylenic with a sulfonic group, in free or partially or totally neutralized form and comprising at least one hydrophobic part. These polymers can be crosslinked or non-crosslinked. They are preferably crosslinked.

[0133] The ethylenically unsaturated monomers with a sulfonic group are chosen in particular from vinylsulfonic acid, styrenesulfonic acid, (meth)acrylamido(Ci-C22)alkylsulfonic acids, N-(Ci-C22)alkyl(meth)acrylamido-(Ci-C22)alkylsulfonic acids such as undecyl-acrylamido-methane-sulfonic acid as well as their partially or totally neutralized forms.

[0134] More preferably, (meth)acrylamido(Ci-C22) alkylsulfonic acids will be used, such as, for example, acrylamido-methanesulfonic acid, acrylamido-ethanesulfonic acid, acrylamido-propanesulfonic acid, 2-acrylamido-2-methylpropanesulfonic acid, methacrylamido-2-methylpropanesulfonic acid, 2-acrylamido-n-butanesulfonic acid, 2-acrylamido-2,4,4-trimethylpentanesulfonic acid, 2-methacrylamido-dodecylsulfonic acid, 2-acrylamido-2,6-dimethyl-3-heptanesulfonic acid, as well as their partially or totally neutralized forms.

[0135] More particularly, 2-acrylamido-2-methylpropanesulfonic acid (AMPS) and its partially or totally neutralized forms will be used.

[0136] The polymers of this family may in particular be chosen from random amphiphilic polymers of AMPS modified by reaction with a C6-C22 n-monoalkylamine or di-n-alkylamine, and such as those described in patent application WO 00 / 31154 (forming an integral part of the content of the description). These polymers may also contain other ethylenically unsaturated hydrophilic monomers chosen for example from (meth)acrylic acids, their alkyl derivatives substituted in [3] or their esters obtained with monoalcohols or mono- or poly-alkylene glycols, (meth)acrylamides, vinylpyrrolidone, maleic anhydride, itaconic acid or maleic acid or mixtures of these compounds.

[0137] The preferred polymers of this family are chosen from amphiphilic copolymers of AMPS and at least one hydrophobic monomer with ethylenic unsaturation.

[0138] These same copolymers may also contain one or more ethylenically unsaturated monomers not comprising a fatty chain such as (meth)acrylic acids, their alkyl derivatives substituted in [3] or their esters obtained with monoalcohols or mono- or polyalkylene glycols, (meth)acrylamides, vinylpyrrolidone, maleic anhydride, itaconic acid or maleic acid or mixtures of these compounds.

[0139] These copolymers are described in particular in patent application EP-A-750899, patent US 5089578 and in the following publications by Yotaro Morishima:

[0140] - “Self-assembly amphiphilic polyelectrolytes and their nanostructures - Chinese Journal of Polymer Science Vol. 18, No. 40, (2000), 323-336. » ;

[0141] - “Miscelle formation of random copolymers of sodium 2-(acrylamido)-2-methylpropanesulfonate and a non-ionic surfactant macromonomer in water as studied by fluorescence and dynamic light scattering - Macromolecules, Vol. 33, No. 10 (2000), 3694-3704”;

[0142] - “Solution properties of miscelle networks formed by non-ionic moieties covalently bound to an polyelectrolyte: known effects on rheological behavior - Langmuir, Vol. 16, No. 12, (2000) 5324-5332”;

[0143] - “Stimuli responsive amphiphilic copolymers of sodium 2-(acrylamido)-2-methylpropanesulfonate and associative macromonomers - Polym. Preprint, Div. Polym. Chem., 40(2), (1999), 220-221”.

[0144] Among these polymers, we can cite:

[0145] - crosslinked or non-crosslinked copolymers, neutralized or not, comprising from 15 to 60% by weight of AMPS units and from 40 to 85% by weight of (C8-Ci6)alkyl(meth)acrylamide units or (C8-Ci6)alkyl(meth)acrylate units relative to the polymer, such as those described in application EP-A750 899;

[0146] - terpolymers comprising from 10 to 90 mol% of acrylamide units, from 0.1 to 10 mol% of AMPS units and from 5 to 80 mol% of n-(C6-Ci8)alkylacrylamide units, such as those described in US patent 5089578.

[0147] Mention may also be made of copolymers of fully neutralized AMPS and dodecyl methacrylate as well as non-crosslinked and crosslinked copolymers of AMPS and n-dodecylmethacrylamide, such as those described in the Morishima articles cited above.

[0148] Among the cationic associative polymers we can cite:

[0149] (a) cationic associative polyurethanes;

[0150] (b) the compound marketed by the company NOVEON under the name AQUA CC and which corresponds to the INCI name POLYACRYLATE-1 CROSSPOLYMER.

[0151] POLYACRYLATE-1 CROSSPOLYMER is the product of the polymerization of a mixture of monomers comprising: - a di(CrC4 alkyl)amino(Ci-C6 alkyl)methacrylate, - one or more C1-C30 alkyl esters of (meth)acrylic acid, - a polyethoxylated Cio-C3o alkyl methacrylate (20-25 moles of ethylene oxide unit), - a polyethylene glycol / polypropylene glycol 30 / 5 allyl ether, - a hydroxy(C2-C6 alkyl) methacrylate, and - an ethylene glycol dimethacrylate.

[0152] (c) quaternized (poly)hydroxyethylcelluloses modified by groups comprising at least one fatty chain, such as alkyl, arylalkyl, al-kylaryl groups comprising at least 8 carbon atoms, or mixtures thereof. The alkyl radicals carried by the above quaternized celluloses or hydroxyethylcelluloses preferably comprise from 8 to 30 carbon atoms. The aryl radicals preferably denote phenyl, benzyl, naphthyl or anthryl groups. Examples of quaternized alkylhydroxyethylcelluloses with C8-C30 fatty chains, such as the products QUATRISOFT LM 200®, QUATRISOFT LM-X 529-18-A®, QUATRISOFT LM-X 529-18-B® (C12 alkyl) and QUATRISOFT LM-X 529-8® (C[8 alkyl) sold by the company AQUALON, the products CRODACEL QM®, CRODACEL QL® (C12 alkyl) and CRODACEL QS® (C18 alkyl) sold by the company CRODA and the product SOFTCAT SL 100® sold by the company AQUALON.

[0153] (d) cationic polyvinyllactam polymers.

[0154] Such polymers are for example described in patent application WO-00 / 68282.

[0155] As cationic poly(vinyllactam) polymers according to the invention, use is made in particular of vinylpyrrolidone / dimethylaminopropylmethacrylamide / dodecyldimethylmethacrylamidopropylammonium tosylate terpolymers, vinylpyrrolidone / dimethylaminopropylmethacrylamide / cocoyldimethylmethacrylamidopropylammonium tosylate terpolymers, vinylpyrrolidone / dimethylaminopropylmethacrylamide / lauryldimethylmethacrylamidopropylammonium tosylate or chloride terpolymers.

[0156] The amphoteric associative polymers are preferably chosen from those comprising at least one non-cyclic cationic unit. More particularly still, those prepared from or comprising 1 to 20 mol% of monomer comprising a fatty chain, and preferably 1.5 to 15 mol% and even more particularly 1.5 to 6 mol%, relative to the total number of moles of monomers, are preferred.

[0157] Amphoteric associative polymers according to the invention are for example described and prepared in patent application WO 9844012.

[0158] Among the amphoteric associative polymers according to the invention, acrylic acid / (meth)acrylamidopropyl trimethyl ammonium chloride / stearyl methacrylate terpolymers are preferred.

[0159] The non-ionic type associative polymers which can be used according to the invention are preferably chosen from:

[0160] (a) copolymers of vinyl pyrrolidone and hydrophobic chain monomers fat, of which we can cite as examples:

[0161] - ANTARON V216® or GANEX V216® products (vinylpyrrolidone copolymer / hexadecene) sold by the company ISP

[0162] - ANTARON V220® or GANEX V220® products (vinylpyrrolidone copolymer / eicosene) sold by the company ISP

[0163] (b) copolymers of C1-C6 alkyl methacrylates or acrylates and amphiphilic monomers comprising at least one fatty chain such as, for example, the methyl acrylate / oxyethylenated stearyl acrylate copolymer sold by the company GOLDSCHMIDT under the name ANTIL 208®.

[0164] (c) copolymers of hydrophilic methacrylates or acrylates and monomers hydrophobic comprising at least one fatty chain such as for example the polyethylene glycol methacrylate / lauryl methacrylate copolymer.

[0165] (d) polyether polyurethanes comprising in their chain, both sequences hydrophilic, most often polyoxyethylenated in nature, and hydrophobic sequences which can be aliphatic chains alone and / or cycloaliphatic and / or aromatic chains.

[0166] (e) polymers with an aminoplast ether skeleton having at least one chain fatty, such as the PURE THIX® compounds offered by the company SUD-CHEMIE.

[0167] (f) celluloses or their derivatives, modified by groups comprising at least less than one fatty chain such as alkyl, arylalkyl, alkylaryl groups or mixtures thereof where the alkyl groups are C8- and in particular:

[0168] * non-ionic alkylhydroxyethylcelluloses such as NATROSOL products PLUS GRADE 330 CS and POLYSURF 67 (C16 alkyl) sold by the company AQUALON

[0169] * non-ionic nonoxynylhydroxyethylcelluloses such as the product AMERCELL HM-1500 sold by the company AMERCHOL;

[0170] * non-ionic alkylcelluloses such as the product BERMOCOLL EHM 100 sold by the company BEROL NOBEL;

[0171] (g) associative guar derivatives such as hydroxypropyl guars modified with a fatty chain such as the product ESAFLOR HM 22 (modified by a C 22 alkyl chain) sold by the company LAMBERTI; the product MIRACARE XC 95-3 (modified by a C14 alkyl chain) and the product RE 205-146 (modified by a C 20 alkyl chain) sold by RHODIA CHIMIE.

[0172] Preferably, the polyurethane polyethers comprise at least two lipophilic hydrocarbon chains, having from 6 to 30 carbon atoms, separated by a hydrophilic sequence, the hydrocarbon chains possibly being pendant chains or chains at the end of a hydrophilic sequence. In particular, it is possible for one or more pendant chains to be provided. In addition, the polymer may comprise a hydrocarbon chain at one end or at both ends of a hydrophilic sequence.

[0173] Polyether polyurethanes can be multi-block, particularly in triblock form. The hydrophobic blocks can be at each end of the chain (for example: triblock copolymer with hydrophilic central block) or distributed both at the ends and in the chain (multi-block copolymer for example). These same polymers can also be in graft or star form.

[0174] The non-ionic fatty chain polyurethane polyethers may be triblock copolymers whose hydrophilic sequence is a polyoxyethylenated chain comprising from 50 to 1000 oxyethylenated groups. The non-ionic polyurethane polyethers comprise a urethane bond between the hydrophilic sequences, hence the origin of the name.

[0175] By extension, non-ionic fatty chain polyurethane polyethers also include those whose hydrophilic sequences are linked to the lipophilic sequences by other chemical bonds.

[0176] As examples of non-ionic fatty chain polyurethane polyethers which can be used in the invention, it is also possible to use Rhéolate 205® with urea function sold by the company RHEOX or even Rhéolates® 208, 204 or 212, as well as Acrysol RM 184®.

[0177] Mention may also be made of the product ELFACOS T210® with a C12-i4 alkyl chain and the product ELFACOS T212® with a C[8] alkyl chain from AKZO.

[0178] The product DW 1206B® from ROHM & HAAS with a C2o alkyl chain and a urethane bond, offered at 20% dry matter in water, can also be used.

[0179] It is also possible to use solutions or dispersions of these polymers, particularly in water or in a hydroalcoholic medium. By way of example, such polymers include RHEOLATE® 255, RHEOLATE® 278 and RHEOLATE® 244 sold by the company RHEOX. It is also possible to use the product DW 1206F and DW 1206J offered by the company ROHM & HAAS.

[0180] The polyether polyurethanes which can be used according to the invention are in particular those described in the article by G. Fonnum, J. Bakke and Fk. Hansen - Colloid Polym. Sci 271, 380.389 (1993).

[0181] More particularly still, it is preferred to use a polyether polyurethane capable of being obtained by polycondensation of at least three compounds comprising (i) at least one polyethylene glycol comprising from 150 to 180 moles of ethylene oxide, (ii) stearyl alcohol or decyl alcohol and (iii) at least one diisocyanate.

[0182] Such polyether polyurethanes are sold in particular by the company ROHM & HAAS under the names ACULYN 46® and ACULYN 44® [ACULYN 46® is a polycondensate of polyethylene glycol with 150 or 180 moles of ethylene oxide, stearyl alcohol and methylene bis(4-cyclohexylisocyanate) (SMDI), at 15% by weight in a matrix of maltodextrin (4%) and water (81%); ACULYN 44® is a polycondensate of polyethylene glycol with 150 or 180 moles of ethylene oxide, decyl alcohol and methylene bis(4-cyclohexylisocyanate) (SMDI), at 35% by weight in a mixture of propylene glycol (39%) and water (26%)].

[0183] Preferably, the composition comprises one or more thickening polymers; preferentially chosen from non-associative thickening polymers without sugar units, anionic associative thickening polymers, in particular anionic associative acrylic polymers, and mixtures thereof.

[0184] Preferably, when the thickening polymer(s) are present in the composition according to the invention, the total content of thickening polymer(s) is comprised in the range from 0.05 to 4% by weight, more preferably from 0.1 to 2% by weight, more preferably still from 0.2 to 1% by weight, and even better from 0.3 to 0.8% by weight, relative to the total weight of the composition.

[0185] viii) Organic solvents The composition according to the invention may optionally comprise one or more organic solvents, different from the hydroxylated compounds v) previously described.

[0186] These organic solvents are preferably chosen from C1-C5 monoalcohols, preferably C2-C4. In a particularly preferred manner, ethanol will be used.

[0187] Preferably, the composition comprises one or more organic solvents different from the hydroxylated compounds v) previously described, preferably one or more C2-C4 monoalcohols, better still ethanol.

[0188] When it(they) is(are) present, the total content of organic solvents other than the hydroxylated compounds v) preferably ranges from 1 to 60% by weight, preferably from 5 to 50% by weight, more preferably from 10 to 40% by weight, better still from 20 to 35% by weight relative to the total weight of the composition.

[0189] When the composition comprises ethanol, the ethanol content preferably ranges from 1 to 60% by weight, preferably from 5 to 50% by weight, more preferably from 10 to 40% by weight, better still from 20 to 35% by weight relative to the total weight of the composition.

[0190] The composition is preferably aqueous. More preferably, the total water content of the composition according to the invention is in the range from 10 to 90% by weight, more preferably still from 20 to 80% by weight, and even better still from 40 to 70% by weight relative to the total weight of the composition.

[0191] Additives The composition may optionally further comprise one or more additives different from the compounds previously described such as those chosen from cationic, anionic, amphoteric or zwitterionic surfactants and their mixtures, cationic, anionic, non-ionic, amphoteric polymers, different from the thickening polymers previously described, or their mixtures, anti-dandruff agents, antiseborrheic agents, vitamins and pro-vitamins including panthenol, sunscreens, sequestering agents, plasticizing agents, solubilizing agents, acidifying agents, opacifying or pearlescent agents, antioxidants, hydroxyacids, perfumes, preservatives and ceramides.

[0192] Of course, those skilled in the art will take care to choose this or these possible complementary compounds in such a way that the advantageous properties intrinsically attached to the composition according to the invention are not, or not substantially, altered by the addition(s) envisaged.

[0193] The above additives may generally be present in an amount of between 0 and 20% by weight for each of them, relative to the total weight of the composition.

[0194] Method The invention also relates to a method for the cosmetic treatment of human keratin materials such as the skin, in particular the scalp, hair and / or human eyelashes, comprising at least the application to said keratin materials of the cosmetic composition as defined above.

[0195] The composition according to the present invention is preferably applied topically, in particular to the scalp and / or hair. Advantageously, the composition according to the invention comprises a cosmetically acceptable medium suitable for topical application.

[0196] The application of the composition may optionally be followed or not by rinsing after a possible exposure time.

[0197] Preferably, the application of the composition according to the invention is not followed by rinsing.

[0198] Preferably, the cosmetic treatment process is a hair and / or scalp care process.

[0199] The present invention also relates to the use of a cosmetic composition as defined above for treating hair loss, and / or promoting regrowth, of keratin fibers.

[0200] The present invention also relates to the use of a cosmetic composition as defined above for increasing the diameter of keratin fibers and / or strengthening keratin fibers against breakage.

[0201] The following examples serve to illustrate the invention without, however, being limiting in nature.

[0202] Examples In the following examples, all quantities are indicated as a percentage by mass of active ingredient (%ma) relative to the total weight of the composition (unless otherwise stated).

[0203] a) Compositions Compositions A according to the invention and comparative B (reference) were prepared from the ingredients whose contents are indicated in the table below:

[0204] [Tables 1] Composition A Composition B Caffeine 2 2 Diaminopyrimidine oxide 1.5 1.5 Piroctone olamine 0.25 0.25 Eperua falcata bark extract (Eperuline PWLS 9627 from BASF) 0.08 (%ma) - Acrylates / Beheneth-25 Methacrylate Copolymer 0.38 0.38 Glycerol 2 2 Propylene glycol 2.5 2.5 PEG-40 hydrogenated castor oil 0.1 0.1 Ethanol 27 27 Water Qsp 100 Qsp 100

[0205] b) Protocol The compositions were tested on 2.7g strands of natural hair of Caucasian origin.

[0206] • Cleaning the wicks before applying the compositions: The hair strands were previously cleaned with DOP shampoo at a rate of 0.4 g per gram of hair. The strands were kneaded and then rinsed 10 times. They were then wrung out twice between 2 fingers and then combed.

[0207] • Application of the compositions on damp hair: The compositions were applied at a rate of 0.4g of composition for a 2.7g strand.

[0208] The strands are then combed to separate the fibers and distribute the product evenly over the fibers. The strands are finally smoothed by hand The strands were then blow-dried at a moderate temperature. c) Evaluation

[0209] The strands were blindly evaluated by experts for 3 criteria: cosmeticity, flexibility and detangling (more loose hair).

[0210] The notes are positioned relative to composition B which serves as a reference (note 0). The notes range from +3 (very good effect) to -3 (very bad effect). Detangling:

[0211] Definition of detangling: the comb passes easily through the strand

[0212] The detangling of the strand is assessed by making 1 pass with the small teeth of the comb from the root to the tip of the strand. Evaluation protocol:

[0213] The strand is hung on a rack and held in one hand by its top. The comb (fine teeth) is placed at 45° to the root of the strand, then the comb is slid to the tip. If the comb (fine teeth) blocks, perform the same gesture with the comb (large teeth). If the comb does not pass, start detangling at the tip of the strand and repeat the action, gradually moving up the strand to the root.

[0214] Result: Detangling is easier for the strand having been treated with composition A according to the invention. Flexibility:

[0215] Definition of flexibility: the wick can be bent without resistance, it is not hardened. Evaluation protocol:

[0216] The wick is hung on a rack and held in one hand by its top. With the other hand, the wick is folded in the palm of the hand and tightened 3 times, for 1 second per tightening.

[0217] Result: The wick having been treated with composition A according to the invention has improved flexibility compared to the wick treated with the comparative reference composition B. Cosmetics:

[0218] Definition of cosmeticity: cosmeticity is evaluated on the criteria of smooth and regular touch.

[0219] Results: The strand having been treated with composition A according to the invention has improved cosmeticity compared to the strand treated with the comparative reference composition B.

[0220] The following table 2 summarizes the different results obtained: [Tables 2] Expert 1 Expert 2 Composition ABAB Cosmeticity +1.5 0 +2 0 Detangling +2 0 +2 0 Softness +1 0 +1 0

[0221] The table shows that composition A according to the invention leads to better detangling of the hair (loose hair), improved flexibility and better cos- meticity than comparative composition B.

Claims

Claims

1. A cosmetic composition comprising: i) 2,4-diaminopyrimidine-3-N-oxide and / or one of its organic or mineral acid salts and / or one of its hydrates, ii) piroctone olamine, iii) caffeine, and iv) an extract of Eperua falcata bark.

2. Composition according to the preceding claim, characterized in that the total content of 2,4-diaminopyrimidine-3-N-oxide and / or one of its organic or mineral acid salts and / or one of its hydrates, ranges from 0.05 to 8% by weight, preferably from 0.1 to 5% by weight, preferentially from 0.2 to 4% by weight, more preferentially from 0.5 to 3% by weight, and better still from 1 to 2% by weight, relative to the total weight of the composition.

3. Composition according to any one of the preceding claims, characterized in that the total content of piroctone olamine ranges from 0.05 to 2% by weight, preferably from 0.1 to 1% by weight, preferentially from 0.1 to 0.5% by weight, relative to the total weight of the composition.

4. Composition according to any one of the preceding claims, characterized in that the total caffeine content ranges from 0.1 to 10% by weight, preferably from 0.5 to 5% by weight, preferentially from 1 to 4% by weight, and more preferentially from 1.5 to 3% by weight, relative to the total weight of the composition.

5. Composition according to any one of the preceding claims, characterized in that the total content of Eperua falcata bark extract ranges from 0.02 to 0.2% by weight, preferably from 0.05 to 0.1% by weight, relative to the total weight of the composition.

6. Composition according to any one of the preceding claims, characterized in that it further comprises v) one or more hydroxylated compounds having a melting point of less than 25°C and a boiling point of greater than or equal to 170°C, at atmospheric pressure; preferably chosen from linear C2-C8 diols or aromatic C6-C8 monoalcohols, and mixtures thereof; more preferably from linear C2-C8 diols, better still C2-C6; even more preferably propylene glycol.

7. Composition according to the preceding claim, characterized in that the total content of the hydroxylated compound(s) v) ranges from 0.5 to 15% by weight, preferably from 1 to 10%, preferentially from 1.5 to 8% by weight. weight, more preferably from 2 to 6% by weight, relative to the total weight of the composition.

8. Composition according to any one of the preceding claims, characterized in that it further comprises an extract of yeasts of the genus Pichia minuta, preferably in a total content ranging from 0.02 to 0.2% by weight, more preferably from 0.03 to 0.1% by weight, relative to the total weight of the composition.

9. Composition according to any one of the preceding claims, characterized in that it further comprises one or more thickening polymers, preferably chosen from non-associative thickening polymers without sugar units, anionic associative thickening polymers, in particular anionic associative acrylic polymers, and mixtures thereof.

10. Process for non-therapeutic cosmetic treatment of human keratin materials such as the skin, in particular the scalp, hair and / or human eyelashes, comprising the application to said keratin materials of a composition as defined in any one of the preceding claims.

11. Non-therapeutic use of a composition as defined in any one of claims 1 to 9 for treating hair loss and / or promoting regrowth of keratin fibers.

12. Use of a composition as defined in any one of claims 1 to 9 for increasing the diameter of keratin fibers and / or strengthening keratin fibers against breakage.