Oral composition

Abstract

The present invention relates to an oral-dental composition comprising at least one abrasive filler selected from the group comprising at least one film-forming agent, and at least one fluorine salt, said composition being free of silicone, to a method for non-therapeutic treatment of the oral cavity comprising the application to a dental surface of said oral-dental composition and to the use of the oral-dental composition for remineralizing teeth. The present invention relates to a method for manufacturing an oral-dental composition. The present invention finds application in particular in the cosmetic and oral-dental fields.

Description

Title of the invention: Oral-dental composition Technical field of the invention

[0001] The present invention relates to an oral-dental composition comprising at least one abrasive filler chosen from the group comprising at least one film-forming agent, and at least one fluorine salt, said composition being free of silicone.

[0002] The present invention also relates to a method of non-therapeutic treatment of the oral cavity comprising the application to a dental surface of said oral-dental composition.

[0003] The present invention also relates to the use of the oral-dental composition for remineralizing teeth.

[0004] The present invention relates to a method of manufacturing an oral-dental composition

[0005] The present invention finds application in particular in the cosmetic and oral-dental fields.

[0006] In the description below, the references in parentheses () refer to the list of references presented at the end of the text. Prior art

[0007] The most common compositions for oral hygiene are toothpastes and mouthwashes. They are used in particular for cleaning the surfaces of the oral cavity, in particular the teeth and gums. Other forms of oral compositions are also known, for example in the form of varnishes, gels, foams or sealants, for example. All these compositions are oral compositions which are not intentionally swallowed for the purpose of systemic administration of therapeutic agents, but are applied to the oral cavity for local treatment.

[0008] In addition to the well-known cleaning action, an oral composition may also perform other functions in the context of oral hygiene, for example an antibacterial effect, remineralization of the tooth enamel and / or strengthening of the gum. These functions are provided or promoted by different substances contained in the preparation which may contribute to the various aspects of the maintenance of the oral sphere.

[0009] An additive to oral hygiene compositions well known to the general public is fluoride, more precisely fluoride in the form of one of its salts. Fluoride salts are distinguished according to the compositions; they may be, for example, potassium, sodium and tin fluorides, amine fluorides and ammonium fluorides. quaternary. Fluoride plays an important role in tooth mineralization, both during tooth formation and daily in the context of enamel demineralization / remineralization cycles. Indeed, it is known that dental enamel is frequently subject to risks of weakening by ionic mobilization, particularly under conditions of acidification of the oral pH when eating acidic or sugary foods, a phenomenon that is favored by the metabolic action of bacteria in the dental biofilm. Under these acidic conditions, certain ions in dental enamel are then dissolved, including calcium phosphates, which represent the main part of the mineral body of teeth, in the form of hydroxyapatite. Depending on the concentrations of calcium and phosphate in saliva near the teeth, this demineralization may prevail over the remineralization of the enamel that occurs after the rise in oral pH.A progressive degradation of dental enamel and even dentin can then occur over time, leading to the appearance of carious lesions.

[0010] There is therefore a real need in the state of the art to find a means and / or an oral composition for protecting dental enamel and / or dentin. There is therefore a real need in the state of the art to find a means and / or an oral composition for preventing carious lesions.

[0011] It is known that the process described above can be inhibited or, preferably, even reversed, by measures that protect and strengthen the tooth enamel. For example, fluoride exerts a preventive and curative action in this context: it protects the tooth enamel by the formation of fluorapatite which is more resistant to acids than hydroxyapatite, and it contributes to the repair of the enamel by accelerating the integration of calcium and phosphate into the mineral body of the teeth. The fluoride then shows a beneficial activity both in reducing demineralization and in promoting remineralization of the teeth. It is also known that fluoride can have an effect in preventing the formation of caries via an antibacterial activity at the level of the oral flora.

[0012] Other components present in oral compositions are also known to contribute to the protection of teeth against the risk of demineralization, these may be, for example, film-forming agents. Known film-forming agents include polymers that form a film around the hard tissue of the teeth, thus providing possible protection, for example, against the action of bacteria and acids. Depending on their chemical nature, they may also promote the retention of ions, particularly calcium and phosphate, around the teeth and thus contribute to effective remineralization (Gullo Augusto et al 2022 (Reference 1)). In addition, certain film-forming agents may also promote the action of fluoride in oral compositions that also contain this ingredient.

[0013] Among the film formers, an important class of compounds is notably represented by silicones, synthetic polymers based on silicon-oxygen chains, and in particular organosilicones which carry organic substitutes / residues. One of the film formers of the organosilicone class which is well known for its usefulness in oral-dental compositions is notably dimethicone, also called polydimethylsiloxane or PDMS. This product is thus found in combination with fluoride salts in various oral-dental compositions, for example toothpaste, available commercially.

[0014] However, silicones included in compositions for hygiene and care, for example in oral-dental compositions, are viewed critically by consumers. In addition, silicones are increasingly controversial substances, particularly by many consumers, especially in their use in oral-dental compositions. In particular, there is a strong demand in the state of the art, particularly by consumers, for “natural” compositions and / or compositions in accordance with the concept of “Naturality”, respect for natural resources and the concept of “clean beauty”. Also, consumers are looking for alternative care products, with ingredients preferably of natural origin, known for their better tolerance, and with a low impact on natural resources and the environment.

[0015] Also, there exists in the state of the art a need to find alternative compositions and / or ingredients and / or daily care products. In particular, there exists in the state of the art a real need to find minimalist compositions, for example comprising a limited number of components and / or ingredients, and / or “natural” compositions.

[0016] Contrary to these trends, silicones are synthetic products that are suspected of accumulating in the environment and even harming health. However, silicones are not easily substituted, because of their well-suited film-forming properties, particularly in toothpastes and mouthwashes.

[0017] There is therefore a real need in the state of the art to find alternative compositions and / or ingredients and / or daily care products. In particular, there is a real need to find compositions and / or ingredients and / or daily care products free of silicones.

[0018] There is also a real need in the state of the art to find compositions and / or ingredients and / or products free of silicone which advantageously allow, for example, the promotion of the action of fluoride, and / or for example allowing protection of dental enamel and / or allowing prevention of the formation of cavities. Statement of the invention

[0019] The present invention aims precisely to meet these needs by providing an oral-dental composition comprising at least one film-forming agent chosen from the group comprising chitosan and / or its derivatives, preferably chitosan mandelate, and at least one fluorine salt, said composition being free of silicone.

[0020] In particular, the inventors have demonstrated in a surprising and unexpected manner that the composition according to the invention advantageously allows protection of the teeth, prevention of carious lesions, inhibition and / or prevention of bacterial adhesion on the dental surface.

[0021] The inventors have also demonstrated, surprisingly and unexpectedly, that the composition according to the invention advantageously allows protection of the teeth, prevention of carious lesions, inhibition and / or prevention of bacterial adhesion to the dental surface, and advantageously promotion of the remineralization of the teeth.

[0022] Furthermore, the inventors have demonstrated in a surprising and unexpected manner that the composition according to the invention not comprising silicone advantageously allows protection of the teeth, prevention of carious lesions, inhibition and / or prevention of bacterial adhesion on the dental surface, and promotion of remineralization of the teeth.

[0023] Furthermore, the composition according to the invention advantageously makes it possible to respond to the concept of “conscious care” via in particular a reduction in the concentrations of the compounds and / or ingredients in the compositions, advantageously making it possible to increase the naturalness of said composition.

[0024] The composition according to the invention also advantageously makes it possible to meet the requirements of certification of the COSMOS standard as defined by Ecocert (registered trademark), which defines the criteria that must be respected to guarantee consumers that their products are genuine organic or natural products manufactured according to the highest possible sustainability practices.

[0025] Advantageously, the composition according to the invention comprises ingredients and / or compounds meeting the requirements of the COSMOS certification defined by Ecocert, in particular COSMOS organic. In addition, the composition according to the invention advantageously has a percentage of naturalness according to the ISO 16128 standard published in September 2017 (Reference 2) greater than 80%, preferably greater than 90%, even more preferably greater than 92%, for example greater than 94%.

[0026] The composition according to the invention may also meet one or more of the characteristics described below, implemented in isolation or in each of their technically effective combinations.

[0027] The ingredients contained in the composition according to the invention may independently be of natural origin. Preferably, the ingredients contained in the composition according to the invention are of natural origin.

[0028] Advantageously, the composition comprising ingredients of natural origin makes it possible in particular to meet a need of the state of the art in the field of care, for example cosmetics, namely compositions containing ingredients of natural origin.

[0029] According to the invention, the oral-dental composition may comprise at least 80%, for example at least 90%, for example at least 95%, of ingredients of natural origin.

[0030] In the present, the percentage of ingredients of natural origin present in the composition can be determined according to the method described in standard ISO 16128:2017 (Reference 2).

[0031] The inventors have also demonstrated in a surprising and unexpected manner that the composition according to the invention advantageously allows, in particular by the combination in the composition of at least one film-forming agent, for example of natural origin, for example chosen from the group comprising chitosan and / or its derivatives and at least one fluorine salt, said composition being free of silicone, a remineralization of the dental surface and / or the teeth and synergistically to inhibit and / or prevent bacterial adhesion on the dental surface, while respecting the various expectations of consumers in terms of organoleptic qualities, namely in particular their sensation in the mouth, compatibility between components and reduction / decrease, for example compared to known oral-dental compositions, the number and / or concentrations of materials / ingredients in the composition.

[0032] The inventors have also demonstrated that the composition according to the invention, free of silicone, has a remineralizing power and a protective activity against the demineralization of the teeth and / or the dental surface. The inventors have also demonstrated that the composition according to the invention, free of silicone, advantageously allows remineralization of the teeth and / or the dental surface and a protective activity against the demineralization of the teeth and / or the dental surface. The inventors have also demonstrated that the composition according to the invention, free of silicone, has an anti-biofilm action, advantageously an anti-bacterial biofilm action. In addition, said composition is also distinguished from comparable compositions of the prior art by the reduction in the concentration of the ingredients, in particular of the non-natural ingredients.

[0033] In this document, by "approximately" is meant that the value concerned may be 10% lower or higher, in particular 5%, in particular 1%, than the value indicated.

[0034] Herein, unless otherwise indicated, the percentages of the components / ingredients, for example in a composition, are given by weight relative to the total weight of the composition.

[0035] In the present invention by the notion that the composition according to the invention comprises an ingredient of a particular category, for example a film-forming agent or a fluorine salt, is meant that the composition according to the invention comprises a single ingredient of this category or several ingredients of this category (mixture of these ingredients), for example film-forming agents or fluorine salts. This is sometimes, but not on every occasion, indicated by the term "at least one", for example at least one film-forming agent or at least one fluorine salt.

[0036] According to the invention, the composition may comprise at least one film-forming agent, preferably of natural origin, other than silicones.This may be, for example, at least one commercially available film-forming agent, for example chosen from glycolipid marketed under the trade reference Rheance (trademark) One by the company Evonik, polyvinylpyrrolidone (PVP) marketed under the trade reference Plasdone (trademark) K-29 / 32 Polymer by the company Ashland, lauroyl arginine marketed under the trade reference Amisafe (trademark) AL01, PVM / MA copolymer / lecithin / aqua marketed under the trade reference Gantrez (trademark) S97 BF, PVM / MA copolymer / aqua marketed under the trade reference Gantrez (trademark) S97 HSU, C15-19 alkane marketed under the trade reference Emogreen (trademark) L15 or L19, the glycerin / ethyl lauroyl arginate HCl mixture PVM / MA Aminat (trademark) G, chitosan mandelate sold under the name Chitosan MS.

[0037] According to the invention, said at least one film-forming agent may be chosen from chitin derivatives. It may, for example, be at least one film-forming agent chosen from chitosan or one of its derivatives.

[0038] In the present invention, chitosan means a polysaccharide composed of D-glucosamine and N-acetyl-D-glucosamine. Chitosan can be produced by deacetylation from chitin found in various crustaceans or cephalopods, or from the wall of fungi. Thus, chitosan is a substance of natural origin within the meaning of the present invention.

[0039] In the present invention, chitosan derivative is understood to mean in particular the spheres, solvates and salts, including acid addition salts. It may be, for example, a solvate or an acid addition salt of pharmacologically or cosmetically acceptable chitosan. It may be, for example, chitosan mandelate.

[0040] In the present by chitosan mandelate also designated chitosan mandelate or chitosan & mandelic acid according to the INCI name means chitosan mandelate, as marketed under the trade name Chitosan MS® by Kraeber & Co GmbH (Germany).

[0041] In the present invention, the chitosan mandelate may be a chitosan mandelate containing between 50 and 70% by weight of chitosan and between 30 and 50% of mandelic acid. The chitosan mandelate may be chosen from chitosan mandelate of marine origin, for example obtained from marine organisms, and / or of fungal origin, for example obtained from mushrooms, or a mixture thereof.

[0042] When the chitosan mandelate is chosen from chitosan mandelate of marine origin, for example obtained from marine organisms, and / or of fungal origin, for example obtained from mushrooms, it can be considered as a product of natural origin within the meaning of the present invention. Preferably, the chitosan mandelate can be chosen from chitosan mandelate of fungal origin. It can be, for example, the chitosan mandelate marketed by the company Kraeber & Co GMBH under the commercial reference Chitosan MS.

[0043] According to the invention, the oral-dental composition may comprise chitosan mandelate as a film-forming agent.

[0044] According to the invention, the concentration of said at least one film-forming agent in the oral-dental composition may be from 0.02 to 1% by weight, for example from 0.025 to 0.25% by weight, for example from 0.05 to 0.15%, for example equal to 0.1% by weight, relative to the total weight of the composition.

[0045] Advantageously, the inventors have demonstrated that, despite the low concentration of the film-forming agent, the film-forming agent present in the composition makes it possible to form a film. In addition, the concentration of the film-forming agent makes it possible to reduce / decrease the manufacturing cost of the composition.

[0046] In the present invention, by fluoride salt is meant any fluoride salt known to those skilled in the art and commercially available suitable for an oral composition. It may be, for example, a fluoride salt chosen from the group comprising potassium fluoride, tin fluoride, amine fluoride, sodium fluoride, quaternary ammonium fluoride. It may be, for example, amine fluoride. It may be, for example, an amine fluoride of the following formula (I):

[0047] [Chem.l]

[0048] Formula I

[0049] in which:

[0050] R1 represents a hydrogen atom or a C1 to C6 alkyl group, for example R1 is H;

[0051] R2 represents a group -CH2OH, -CO2R3, where R3 is a C1 to C6 alkyl group, CONH(CH2)2OH, or a group of formula (II)

[0052] [Chem.2] / >—X p / 7 \ / / / \ / G

[0053] Formula (II), and

[0054] the R2 group is in position 2 or 3 (relative to the nitrogen atom).

[0055] By “C1 to C6 alkyl group” is meant a hydrocarbon chain saturated, linear or branched, comprising 1 to 6, in particular 1 to 4, carbon atoms. The C1 to C6 alkyl group may be chosen from the group comprising methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl and hexyl groups.

[0056] The fluorine salt may be nicomethanol hydrofluoride (fluorinol (registered trademark)), also known as nicomethanol hydrofluoride, which corresponds to a compound of formula (I) in which: R1 is H and R2 is CH2OH and is in position 3 relative to the nitrogen.

[0057] According to the invention, the concentration of said at least one fluorine salt in the oral-dental composition may be from 1% to 10% by weight relative to the total weight of the composition. For example, the composition may be from 1.6% to 5.4% by weight, for example from 1.75 to 5.2% by weight, for example equal to 5% by weight relative to the total weight of the composition.

[0058] According to the invention, the oral-dental composition may comprise from 400 ppm to 1,500 ppm of fluoride, for example from 500 to 1,400 ppm of fluoride, for example 1,450 ppm of fluoride.

[0059] Advantageously, when the fluorine salt is nicomethanol hydrofluoride, for example "fluorinol ("registered trademark"), the composition according to the invention advantageously allows a remineralization superior to that obtained with known compositions comprising mineral fluoride. In other words when the composition comprises a film-forming agent as defined above and a fluorine salt, for example nicomethanol hydrofluoride, the inventors have demonstrated that it advantageously allows the inhibition of demineralization of the dental surface, for example of dental enamel, for example due to acidifying bacteria in the cavity. buccal. In addition, the inventors have also demonstrated that it advantageously increases the mineralization of the dental surface, for example of dental enamel.

[0060] As used herein, "silicones" or "silicone" means any commercially available silicone suitable for use in an oral composition and / or any silicone known to those skilled in the art. These may be, for example, polysiloxanes, for example polysiloxanes in which organic groups such as hydrocarbon residues are attached to the silicon atoms. These may be any silicones known in the context of care products to those skilled in the art.This may be, for example, any silicone known under the INCI name "Silicone", and / or under the specific names of silicones which end in "-methicone" - for example Dimethicone, Cyclomethicone, Phenyltrimethicone, Cetyl dimethicone copolyol, Dimethicone / Phenyl Vinyl Dimethicone Crosspolymer, Diphenyl Dimethicone for example - or which end in "-siloxane" - for example Cyclopentasiloxane, Polysiloxane, Cyclotetrasiloxane, Hexamethyldisiloxane, Octamethylcyclotetrasiloxane, Hexamethyldisiloxane, Drometrizole Trisiloxane. It may be, for example, silicone chosen from the group comprising dimethicones, cyclomethicones, phenyltrimethicones, cetyl dimethicone copolyol, dimethicone / phenyl vinyl dimethicone crosspolymer, diphenyl dimethicone, cyclopentasiloxane, polysiloxane, cyclotetrasiloxane, hexamethyldisiloxane, octamethylcyclotetrasiloxane, hexamethyldisiloxane, drometrizole trisiloxane.

[0061] In the present invention, by composition "free from", "exempt from", "free from", "without" or "does not contain" is meant the fact that the proportion and / or concentration of the substance and / or compound concerned is less than 0.3% by weight, for example less than 0.1% by weight, preferably less than 0.01% by weight, relative to the total weight of the composition. More preferably, the proportion and / or concentration of the substance and / or compound concerned is 0% by weight relative to the total weight of the composition. This does not exclude the possible presence of traces of the substance and / or compound in small quantities, for example in the form of contamination or as a degradation product, for example in a quantity less than 10 ppm, for example less than 5 ppm.

[0062] As used herein, "silicone-free" means a composition comprising a silicone concentration of less than 0.05% by weight, for example less than 0.01%, for example 0% by weight of silicone relative to the total weight of the composition. In other words, a composition comprising less than 10 ppm of silicone, for example comprising 0 ppm of silicone, is meant.

[0063] According to the invention, the oral-dental composition may be free of free calcium salt, for example calcium carbonate (CaCO3) and / or dicalcium phosphate, for example example dicalcium phosphate, CaHP04 and / or calcium hydrogen phosphate.

[0064] According to the invention, the oral-dental composition may be free of ingredients which are nanomaterials according to the definition of Recommendation 2011 / 696 / EU of October 18, 2011 of the European Commission (Reference 3).

[0065] In this document, "nanomaterial" means "nanomaterial" "a natural, accidentally formed or manufactured material containing free particles, in aggregate form or in agglomerate form, of which at least 50% of the particles, in the numerical size distribution, have one or more external dimensions lying between 1 nm and 100 nm" as mentioned in Recommendation 2011 / 696 / EU of 18 October 2011 of the European Commission (Reference 4).

[0066] Advantageously, the composition according to the invention may be free of other substances and / or ingredients. For example, the oral-dental composition may be an example of substances and / or ingredients considered in the state of the art to be controversial. These may be, for example, compounds known to be able, for example, to induce and / or cause side effects and / or have a negative effect on the environment, for example ecotoxic.

[0067] According to the invention, the oral composition may be free of sodium Lauryl Sulfate (SLS). For example, the oral composition may be free of anionic surfactants comprising at least one sulfate group, for example a -O-SO3H or -O-SO2-O group, for example laureth sulfate or lauryl sulfate.

[0068] According to the invention, the oral-dental composition may be free of acrylate-functional compound, for example copolymer of methyl methacrylate and ethylene glycol dimethacrylate.

[0069] According to the invention, the oral-dental composition may be free of preservatives chosen from parabens, for example methylparaben, methyl 4-hydroxybenzoate, ethylparaben, ethyl 4-hydroxybenzoate, propylparaben, isopropylparaben, butylparaben, isobutylparaben, benzylparaben.

[0070] According to the invention, the oral-dental composition may be free of benzyl alcohol and / or phenoxyethanol.

[0071] According to the invention, the oral-dental composition may be free of triclosan or 5-chloro-2-(2,4-dichlorophenoxy)phenol.

[0072] According to the invention, the oral-dental composition may be free of titanium dioxide (TiO2).

[0073] According to the invention, the oral-dental composition may be free of Poly Ethylene Glycols (PEGs).

[0074] According to the invention, the oral-dental composition may further comprise at least one humectant. This may be any humectant known to those skilled in the art suitable for an oral-dental composition. This may be, for example, a polyol, for example chosen from the group comprising glycerol, sorbitol, polyethylene glycol, polypropylene glycol, propylene glycol, propane 1,3 diol and any mixture thereof. For example, the humectant may be sorbitol, for example obtained from a hydrogenated starch hydrolysate. It may be, for example, a commercially available hydrogenated starch hydrolysate (INCI name hydrogenated starch hydrolysate), for example under the reference Neosorb 70 / 7OB, marketed in 70% anhydrous form and comprising approximately 30% water. In other words, the humectant may be chosen from the group comprising glycerol, sorbitol, hydrogenated starch hydrolysate, polyethylene glycol, polypropylene glycol, propylene glycol, propane 1,3 diol and mixtures thereof. For example, the composition may comprise a humectant selected from the group comprising glycerol, sorbitol, and hydrogenated starch hydrolyzate.

[0075] According to the invention, the concentration of said at least one humectant in the composition may be between 2 and 80% by weight, for example between 3 and 75% by weight, for example between 5 and 70% by weight relative to the total weight of the composition.

[0076] Certain polyols which act as humectants may, by virtue of their nature as osidic derivatives, contribute to imparting a sweet taste to the composition. Advantageously, said at least one humectant may prevent the oral-dental composition from drying out, for example in the form of toothpaste, by binding the water in the composition and thus preventing its evaporation and / or by attracting moisture from the air during storage.

[0077] According to the invention, the oral composition may comprise at least one thickening agent. For example, the oral composition may further comprise at least two thickeners. In the present invention, thickening agent means any thickening agent known to a person skilled in the art and suitable and commercially available, for example suitable for use in an oral composition. In the present invention, the thickening agent may also be referred to as thickener or stabilizer.For example, the oral composition may comprise at least one thickener selected from the group comprising synthetic cellulose and / or cellulose derivatives, for example cellulose gum, for example carboxymethylcellulose (CMC, INCI name Cellulose Gum), carboxyethylcellulose, methylcellulose, ethylcellulose, carboxymethylhydroxyethylcellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose and hydroxypropylcellulose as well as their salts, carrageenans for example sodium carrageenan, sodium alginate or algin, guar gums, for example Cyamopsis Tetragonoloba Gum, xanthan gum or xanthan gum, gellan gum or gellan Gum, gum arabic, gum tragacanth, carbomers or carbomer. This may be, for example, a commercially available thickener, such as commercially available carboxymethylcellulose. under the name Blanose cellulose gum 7MF PH or WALOCEL CRT 1000 PA 07, xanthan gum marketed under the name Rheocare XGN, sodium alginate marketed under the name Safic Care TA 80-400, the acacia gum / xanthan gum mixture marketed under the name Solagum AX, carrageenans marketed under the name Algogel CG2801 or Algogel 2501, gellan gum marketed under the name Kelcogel CG LA.

[0078] According to the invention, the concentration of said at least one thickener may be from 0.2 to 10% by weight, for example from 0.25 to 5% by weight, for example from 0.3 to 4% by weight, relative to the total weight of the composition.

[0079] Advantageously, said at least one thickener may be at least one cellulose derivative. The cellulose derivative(s) may be chosen from the group comprising hydroxyethylcellulose, ethylcellulose, hydroxypropylcellulose, carboxymethylcellulose, carboxymethylhydroxyethylcellulose and mixtures thereof. For example, it may be carboxymethylcellulose, also known as carmellose. Carboxymethylcellulose is a very hygroscopic cellulose ether, for example used in the form of its sodium salt, sodium carboxymethylcellulose. It may be commercially available sodium carboxymethylcellulose, for example Blanose 7MF PH marketed by the company Ashland.

[0080] According to the invention, when the composition comprises at least one cellulose derivative as thickener, the concentration of said cellulose derivative may be from 0.5 to 10% by weight or from 1 to 5% by weight, preferably from 1.5 to 4% by weight, in particular from 1.5 to 3% by weight, relative to the total weight of the composition.

[0081] Advantageously, said at least one thickener may be at least one polysaccharide, preferably of natural origin, for example sodium alginate. Alginate is an anionic polymeric polysaccharide, widely present in the cell walls of brown algae. It may be commercially available sodium alginate, for example marketed by the company Safic Alcan under the commercial reference Safic Care TA80-400.

[0082] In the present invention, when the composition comprises sodium alginate as a thickener, the concentration of said sodium alginate may be more than 0.05 up to 3% by weight or from 0.1 to 2.5% by weight, preferably from 0.2 to 1% by weight, in particular from 0.3 to 0.6% by weight, for example equal to 0.4% relative to the total weight of the composition.

[0083] In the present invention, said at least one thickener may be selected from the group comprising cellulose derivatives and polysaccharides, preferably of natural origin, and mixtures thereof. For example, the oral-dental composition may comprise two thickeners, for example at least one cellulose derivative and at least one polysaccharide, preferably of natural origin. For example, the com oral position may comprise two thickeners, for example at least one cellulose derivative and sodium alginate. For example, the oral composition may comprise two thickeners, for example sodium carboxymethylcellulose and sodium alginate. When the composition comprises two thickeners, the total concentration of the two thickeners may be from 0.5 to 10% by weight or from 1 to 5% by weight, preferably from 1.2 to 4% by weight, in particular from 1.3 to 3.6% by weight, relative to the total weight of the composition. For example, when the composition comprises a cellulose derivative and sodium alginate as thickeners, the total concentration of the two thickeners may be from 0.5 to 10% by weight or from 1 to 5% by weight, preferably from 1.2 to 4% by weight, in particular from 1.3 to 3.6% by weight, relative to the total weight of the composition.

[0084] According to the invention, when the composition comprises two thickeners, the ratio of the concentrations of said thickeners may be from 1 / 7 to 1 / 3, preferably from 1 / 6 to 1 / 4. In other words, the ratio of the concentrations of said thickeners may be from 0.14 to 0.33, for example from 0.17 to 0.25, for example equal to 0.2. Advantageously, the concentration of the thickener in the composition allows good stabilization of the composition, while being associated with a reduced manufacturing cost of the composition.

[0085] Advantageously, when the composition comprises at least one thickener or thickening agent, said at least one thickening agent may also advantageously have a gelling effect. In other words, said at least one thickener or thickening agent may also have a gelling agent function. In this case, thickeners with the dual function of thickener and gelling agent are referred to in the context of the present application. These may be, for example, sodium carboxymethylcellulose and / or sodium alginate.

[0086] Advantageously, when the oral-dental composition comprises at least one thickener, it advantageously makes it possible to thicken said composition by forming a network with water.

[0087] The inventors have demonstrated that the nature and quantity of the thickeners advantageously allows an optimization of the composition, advantageously making it possible to give the composition rheological properties adapted to the oral-dental composition. In particular, the consistency and viscosity of the oral-dental composition can advantageously be adapted so that the composition, for example when it is included in a container, for example a tubular container, for example a tube, can advantageously be easily extracted from the container, for example the tube, for example by pressing, in a controlled manner, said composition being advantageously, for example when it is applied to a brushing device, for example a toothbrush, firm and cohesive on said toothbrush. Advantageously, said composition does not flow or fall from said brushing device, for example a toothbrush. Advantageously, the thickener(s) may be chosen according to their ability to stabilize the composition over time, for example in order to avoid a phase shift of the components of said composition during its storage.

[0088] According to the invention, the oral-dental composition may further comprise at least one foaming agent. This may be, for example, any foaming agent known to those skilled in the art belonging to the class of surfactants. This may be, for example, a foaming agent with an HLB of between 3 and 8, for example greater than 3 and less than 8.

[0089] The person skilled in the art, from this general knowledge, knows the HLB (hydrophilic-lipophilic-balance) which can be measured according to the method described in Griffin WC, Classification of Surface-Active Agents by HLB, Journal of the Society of Cosmetic Chemists 1 (1949): 311 (Reference 4), and makes it possible to quantify the balance existing between the hydrophilic part and the lipophilic part of the molecule, a balance linked to the solubility in water. The measurement varies from 0 to 20; the higher the value, the greater the solubility in water.

[0090] In the present invention, the foaming agent may be chosen from the glutamate family, for example sodium cocoyl glutamate, for example commercially available under the trade name Amisoft (registered trademark) CS11 by Unipex, disodium cocoyl glutamate for example commercially available under the trade name Amisoft (registered trademark) ECS22W, disodium cocoyl glutamate for example commercially available under the trade name Eversoft UCS100, sodium myristoyl glutamate for example commercially available under the trade name Amisoft (registered trademark) MS11, sodium lauroyl glutamate (registered trademark) for example commercially available under the trade name Amisoft (registered trademark) LS11.As other examples of foaming agents, it may be a foaming agent chosen from the group of glucosides such as lauryl glucoside, for example, commercially available under the trade name plantacare 1200UP, decyl glucoside, for example, commercially available under the trade name plantacare 2000UP, coco glucoside, for example, commercially available under the trade name Plantacare 818UP, or the taurate family, the glycinate family, the sarcosinate family, the lactylate family with sodium lauroyl lactylate, or coco betaine, for example, commercially available under the trade name Dehyton AB30.

[0091] According to the invention, the concentration of said at least one foaming agent may be from 0.5 to 8% by weight, for example from 1 to 6% by weight, relative to the total weight of the composition.

[0092] Advantageously, the foaming agent allows the formation of foam, dispersion of a large volume of gas in a small volume of liquid which adsorbs at the water-air interface.

[0093] Advantageously, the concentration of the foaming agent makes it possible to obtain a composition comprising good foaming power and good quality of the foam formed, while being associated with a reduced manufacturing cost of the composition.

[0094] According to the invention, said at least one foaming agent may be chosen from the group comprising a non-ionic surfactant and an anionic surfactant.

[0095] In the present invention, the oral-dental composition may further comprise at least one non-ionic surfactant, preferably of plant origin, as a foaming agent. This may be, for example, at least one non-ionic surfactant chosen from the group comprising alkyl glucosides, for example alkyl glucosides in which the alkyl radical comprises from 8 to 16 carbon atoms, for example from 10 to 14 carbon atoms. This may be, for example, a non-ionic surfactant chosen from the group comprising alkyl glucosides in which the alkyl radical comprises from 8 to 16 carbon atoms, for example from 10 to 14 carbon atoms, chosen from the compounds with the INCI names octyl glucoside, lauryl glucoside and decyl glucoside. For example, the composition may comprise lauryl glucoside as a non-ionic surfactant. Preferably, the composition according to the invention comprises lauryl glucoside as the only non-ionic surfactant.

[0096] According to the invention, the concentration of said at least one non-ionic surfactant may be from 0.5 to 5% by weight, for example from 1 to 3% by weight, relative to the total weight of the composition.

[0097] According to the invention, the oral-dental composition may further comprise at least one anionic surfactant, preferably of plant origin, for example as a foaming agent. It may be, for example, at least one anionic surfactant chosen from the group comprising acyl glutamic acids and their salts. It may be, for example, at least one anionic surfactant chosen from acyl glutamic acids and their cosmetically and / or pharmacologically acceptable salts. It may be, for example, at least one anionic surfactant chosen from acyl glutamic acids whose acyl group comprises a linear or branched, saturated or unsaturated hydrocarbon chain of 8 to 30 carbon atoms, for example of 10 to 20 carbon atoms, for example of 12 to 18 carbon atoms. The acyl group may in particular be chosen from the lauroyl, myristoyl, palmitoyl, stearoyl, olivoyl, cocoyl and oleoyl groups.The cosmetically or pharmacologically acceptable salt of acyl glutamic acid may be chosen from alkali metal salts, alkaline earth metal salts and ammonium salts. It may be chosen, for example, from sodium, potassium, lithium or magnesium salts, sodium and . potassium being particularly preferred in the context of the invention. Said at least one anionic surfactant may be chosen from acyl glutamic acids and their cosmetically and / or pharmacologically acceptable salts chosen from the group comprising sodium cocoyl glutamate, disodium cocoyl glutamate, sodium myristoyl glutamate, sodium lauroyl glutamate, potassium lauroyl glutamate, potassium cocoyl glutamate and sodium stearoyl glutamate.

[0098] According to the invention, the oral-dental composition may further comprise at least two anionic surfactants chosen from acyl glutamic acids and their cosmetically or pharmacologically acceptable salts.

[0099] According to the invention, the oral-dental composition may comprise a single anionic surfactant chosen from acyl glutamic acids and their cosmetically or pharmacologically acceptable salts.

[0100] According to the invention, the concentration of said at least one anionic surfactant may be from 0.5 to 5% by weight, for example from 1 to 3% by weight, relative to the total weight of the composition.

[0101] According to the invention, the oral-dental composition may comprise as foaming agent a combination or mixture of at least one non-ionic surfactant(s) and at least one anionic surfactant(s), preferably of plant origin. It may be, for example, a combination or mixture of at least one non-ionic surfactant chosen from alkyl glucosides in which the alkyl radical comprises from 8 to 16 carbon atoms, for example from 10 to 14 carbon atoms and at least one anionic surfactant chosen from acyl glutamic acids whose acyl group comprises a linear or branched, saturated or unsaturated hydrocarbon chain of 8 to 30 carbon atoms, for example from 10 to 20 carbon atoms, for example from 12 to 18 carbon atoms, and their salts. For example, the oral composition may include lauryl glucoside and disodium cocoyl glutamate.

[0102] According to the invention, the oral-dental composition may comprise lauryl glucoside and disodium cocoyl glutamate as foaming agents.

[0103] According to the invention, the total concentration of said at least one non-ionic surfactant and said at least one anionic surfactant may be from 1 to 8% by weight, for example from 2 to 6% by weight, relative to the total weight of the composition. For example, the ratio between said at least one non-ionic surfactant and said at least one anionic surfactant may be from 1 / 2 to 2 / 1, preferably from 1 / 1.5 to 1.5 / 1, for example 1 / 1. In other words, the concentration ratio by weight in the composition between said at least one non-ionic surfactant and said at least one anionic surfactant may be from 0.5 to 2, for example from 0.66 to 1.5, for example equal to 1.

[0104] Advantageously, the choice of said non-ionic surfactant and said surfactant anionic and their concentrations make it possible to obtain a composition comprising good foaming power and good quality of the foam formed, while being associated with a reduced manufacturing cost of the composition.

[0105] According to the invention, the oral-dental composition may be free of sodium lauryl sulfate (SLS) and / or alkyl sulfate salt ("alkyl sulfate salt").

[0106] According to the invention, the oral-dental composition may be free of cationic surfactant. In the present invention, the term "cationic surfactant" means any cationic surfactant known to those skilled in the art which may be cited in the INCI dictionary (International Nomenclature of Cosmetic Ingredients) published by the PCPC (Personal Care Products Council).

[0107] According to the invention, the oral-dental composition may further comprise at least one abrasive or abrasive filler. This may be, for example, any abrasive and / or abrasive filler known to those skilled in the art suitable, for example, for use in an oral-dental composition. This may be, for example, a cosmetically and / or pharmacologically acceptable abrasive or abrasive filler. This may be, for example, an abrasive or abrasive filler known to those skilled in the art which may be cited in the INCI (International Nomenclature of Cosmetic Ingredients) dictionary published by the PCPC (Personal Care Products Council). This may be, for example, an abrasive or abrasive filler chosen from a mineral abrasive filler or an organic abrasive filler or any mixture thereof.It may be, for example, an abrasive or abrasive filler that may be selected from the group comprising silica, precipitated particulate silica, silicates, calcium carbonate, dicalcium phosphate, tricalcium phosphate, calcined alumina, sodium and potassium metaphosphate, sodium and potassium pyrophosphates, sodium trimetaphosphate, sodium hexametaphosphate, hydroxyapatite particles (in particles) and / or any mixture thereof. It may be an abrasive filler of mineral origin selected from the group comprising hydrated aluminosilicates, preferably of natural origin, for example volcanic glasses, preferably of natural origin, clays or clay minerals, preferably of natural origin, or any mixture thereof. It may be, for example, volcanic glasses from Turkey. For example, volcanic glass may be perlite.This may be, for example, commercially available perlite, for example marketed by the company Imerys under the trade reference Imercare (trademark) Perlwhite 19. This may be, for example, an organic abrasive filler of plant origin, for example chosen from the group comprising rice powder (Oryza saliva), cellulose powder, preferably microcrystalline cellulose powder, rice starch and any mixture thereof. This may be an organic abrasive filler of animal origin, for example chosen. in the group consisting of coral powder, shell powder, oyster shell powder and any mixture thereof. Examples include

[0108] According to the invention, the concentration of said at least one abrasive or abrasive filler in the composition may be from 0.1 to 20% by weight, for example from 0.5 to 10% by weight, 1 to 6% by weight relative to the total weight of the composition.

[0109] Advantageously, the concentration of abrasive filler in the composition makes it possible in particular to adapt the cleaning power of the oral-dental composition according to the invention. Advantageously, when the composition comprises abrasives or abrasive fillers, it can be useful for cleaning, for example mechanically and / or polishing the teeth and / or the dental surface. Advantageously, the composition can reinforce the action of brushing and advantageously makes it possible to eliminate and / or alter dental plaque and / or unsightly colorations on the teeth and / or the dental surface.

[0110] According to the invention, the oral-dental composition may further comprise water. This may be, for example, purified water. In the present invention, the water concentration may be from 3 to 95% by weight, for example from 5 to 90% by weight, for example from 10 to 90% by weight relative to the total weight of the composition.

[0111] The oral-dental composition may comprise one or more cosmetically or pharmaceutically acceptable carrier(s). In the present invention, the term "cosmetically or pharmaceutically acceptable carrier" means any cosmetic carrier known to those skilled in the art; it may be, for example, any cosmetic or pharmaceutical carrier that may be cited in the INCI (International Nomenclature of Cosmetic Ingredients) dictionary published by the PCPC (Personal Care Products Council).

[0112] The composition according to the invention may comprise one or more adjuvants known to those skilled in the art. This may be, for example, one or more adjuvant(s) chosen from ester-type agents, emollient agents, perfumes, ceramides and pseudo-ceramides, vitamins and provitamins, proteins, sequestering agents, alkalizing agents, acidifying agents, reducing agents, oxidizing agents, colorants, vitamins, flavorings, sweeteners, for example stevia, sodium saccharin, acesulfame potassium, xylitol or any other suitable adjuvant that may be cited in the INCI dictionary (International Nomenclature of Cosmetic Ingredients) published by the PCPC (Personal Care Products Council).

[0113] The composition may also comprise at least one preservative. This may be any preservative known to those skilled in the art suitable for use in an oral-dental composition. This may, for example, be preservatives chosen from sodium benzoate, potassium sorbate, sodium propionate or antibacterial agents such as chlorhexidine, o-cymen 5 ol, cetylpyridinium chloride.

[0114] In the present invention, the concentration of said at least one preservative may be from 0.005 to 2% by weight, for example from 0.01 to 1.5% by weight, for example from 0.05 to 1% by weight relative to the total weight of the composition.

[0115] In the present invention, the oral-dental composition may comprise at least one cosmetically or pharmacologically acceptable excipient known to those skilled in the art suitable for this type of composition.

[0116] By "cosmetically or pharmacologically acceptable excipient" is meant any compound known to those skilled in the art useful in the preparation of a cosmetic or pharmaceutical composition which is generally safe, non-toxic and neither biologically nor otherwise undesirable and which is acceptable for use in human cosmetics or pharmaceuticals, including oral application.

[0117] By "cosmetically or pharmacologically acceptable" is meant any compound known to those skilled in the art useful in the preparation of a cosmetic or pharmaceutical composition which is generally safe, non-toxic and neither biologically nor otherwise undesirable and which is acceptable for use in human cosmetics or pharmaceuticals, including oral application.

[0118] Herein, the oral composition may, for example, be in any suitable form known to those skilled in the art. For example, the composition may be in liquid, semi-solid, or solid form. For example, the oral composition may be a liquid, a fluid, a gel, a paste, or a solid. For example, the oral composition may be in the form of a toothpaste, for example, in the form of a paste, a gel, or a solid. For example, the oral composition may be in the form of a gel or a paste. For example, the composition may be in a liquid form, for example, in the form of a mouthwash.

[0119] For example, the composition according to the invention may be in the form of a toothpaste. It may be, for example, an oral-dental composition which may be used in conjunction with a cleaning instrument, for example, a toothbrush, generally by applying it to the bristles of the toothbrush and then brushing the accessible surfaces of the oral cavity. It may be, for example, a toothpaste in the form of a paste, gel, powder, tablet or liquid. For example, the composition according to the invention may be in the form of a toothpaste in the form of a paste or a gel.

[0120] When the composition is in the form of a toothpaste, it may further comprise at least one compound chosen from the group comprising a thickener, a foaming agent, a non-ionic surfactant, an anionic surfactant, an abrasive filler, a humectant, water and any mixture thereof.

[0121] The oral-dental composition may be obtained by any suitable method known to those skilled in the art for the manufacture of a cosmetic and / or dermatological composition. It may be, for example, a simple mixture. It may be a mixture of surfactant materials in water.

[0122] This may be, for example, a method for manufacturing an oral-dental composition comprising the steps of: (a) preparation of a base of oral-dental composition, b) addition to the composition base prepared in step a) of at least one film-forming agent and at least one fluorine salt, c) recovery of the obtained oral-dental composition

[0123] Step a) may be carried out by any suitable method known to those skilled in the art. This may be, for example, any method for preparing an oral composition and / or oral composition base known to those skilled in the art. This may be, for example, a step comprising mixing, for example with stirring, for example, at least one humectant, at least one thickening agent and water.

[0124] Step a) can be carried out at a temperature of 20 to 30°C, for example at 25°C.

[0125] According to the invention, preparation step a) can be carried out by any method known to those skilled in the art. It may, for example, be mixing with stirring. The mixing in step a) can be carried out for a period of more than 10 minutes, for example from 10 minutes to 20 minutes.

[0126] According to the invention, preparation step a) can be carried out in any suitable container known to those skilled in the art.

[0127] The addition of said at least one film-forming agent in step b) may be carried out by any suitable method known to those skilled in the art. This may, for example, involve adding said at least one film-forming agent to the composition or composition base obtained in step a), for example with stirring, for example until homogenization. The addition of said at least one fluorine salt in step b) may be carried out by any suitable method known to those skilled in the art. This may, for example, involve adding said at least one film-forming agent to the composition or composition base obtained in step a), for example with stirring, for example until homogenization.

[0128] For example, the duration of step b) may be greater than 15 minutes, for example from 15 minutes to 25 minutes.

[0129] According to the invention, the addition of said at least one film-forming agent and said fluorine salt in step b) may be concomitant or successive. For example, step b) may comprise the steps of: b') addition of said at least one film-forming agent, b”) mixing with stirring b'”) addition of said at least one fluorine salt to the mixture obtained in step b”) and b””) mixing with stirring

[0130] The addition of said at least one film-forming agent in step b') may be carried out by any suitable method known to those skilled in the art. This may, for example, involve adding said at least one film-forming agent to the composition or composition base obtained in step a) or to the composition obtained, for example with stirring.

[0131] For example, the duration of step b”) may be greater than 30 minutes, for example from 30 minutes to 40 minutes.

[0132] Step b”) can be carried out at a temperature of 20 to 30°C, for example at 25°C.

[0133] The addition of said fluorine salt in step b'”) may be carried out by any suitable method known to those skilled in the art. This may, for example, involve the addition of said at least one film-forming agent to the composition or mixture obtained in step b”') or to the composition obtained.

[0134] For example, the duration of step b” ”) may be greater than 10 minutes, for example from 10 minutes to 20 minutes.

[0135] Step b” ”) can be carried out at a temperature of 20 to 30°C, for example at 25°C.

[0136] According to the invention, the method may optionally comprise, prior to recovery step c), a step c') of adding at least one abrasive or abrasive filler to the composition obtained in step b). The addition of said at least one abrasive or abrasive filler in step c') may be carried out by any suitable method known to those skilled in the art. This may, for example, be an addition with stirring.

[0137] For example, the duration of step c') may be greater than 5 minutes, for example from 5 minutes to 10 minutes.

[0138] Step c') can be carried out at a temperature of 20 to 30°C, for example at 25°C.

[0139] According to the invention, the process may comprise, prior to recovery step c), a step b1) of adding to the composition obtained in step b) a base comprising at least one foaming agent and optionally at least one colorant. The addition of the base comprising at least one foaming agent and optionally at least one colorant to step b1) may be carried out by any suitable method known to those skilled in the art. This may, for example, be an addition with stirring. For example, the duration of step b1) may be greater than 15 minutes, for example from 15 minutes to 25 minutes. Step b1) may be carried out at a temperature of 20 to 30°C, for example at 25°C.

[0140] The oral-dental composition can be used in a cosmetic treatment, for example a cosmetic treatment for cleaning the dental surface.

[0141] In the present document, by "cosmetic care" is meant, for example, the application to the dental surface of an oral-dental composition according to the invention, for example by means of an applicator, for example a brushing device, for example a toothbrush, for example a manual or electric toothbrush.

[0142] The present invention also relates to a method for non-therapeutic cosmetic treatment of the oral cavity comprising the application to a dental surface of a composition according to the invention.

[0143] The present invention also relates to the use of the oral-dental composition according to the invention for cleaning a dental surface in a human or an animal.

[0144] As used herein, dental surface means a surface of a natural tooth or a hard surface of an artificial denture, for example a crown, cap, filling, bridge, dental implant, etc.

[0145] The present invention also relates to the composition according to the invention for its use in remineralizing teeth.

[0146] In this document, “remineralizing teeth” means in particular the repair of enamel by the integration of calcium and phosphate in the form of hydroxyapatite and / or fluorapatite into the mineral body of the teeth.

[0147] The inventors have demonstrated, surprisingly and unexpectedly, that the composition according to the invention advantageously makes it possible to delay or inhibit the formation of bacterial biofilm on a surface, for example a biotic surface, for example the dental surface. The inventors have also demonstrated, surprisingly and unexpectedly, that the composition according to the invention has an effect on the initial formation of the biofilm, for example the adhesion and adhesion stages, for example by preventing the adhesion of bacteria to the surface.

[0148] Also, the present invention also relates to the composition according to the invention for its use for the prevention and / or inhibition of the formation of a biofilm on a surface.

[0149] In the present invention, by biofilm is meant any biofilm known to those skilled in the art formed by a microorganism, for example it may be a bacterial biofilm. In the present invention, by bacterial biofilm is meant any biofilm known to those skilled in the art capable of being formed by a bacterium. It may be, for example, a biofilm formed by a bacterium chosen from the group comprising Streptococcus mutons, Streptococcus salivarius and Streptococcus sanguinis.

[0150] In the present invention, by surface is meant any surface known to those skilled in the art on which a biofilm can form. It may be, for example, a biotic surface, for example a biotic surface chosen from the group comprising the skin, the mucous membranes, the teeth, preferably the dental surface.

[0151] Herein, the bacterial biofilm may be the dental biofilm.

[0152] The present invention also relates to a non-therapeutic cosmetic treatment kit for the oral cavity comprising an oral-dental composition according to the invention and a support comprising instructions for the use of the oral-dental composition.

[0153] The support comprising instructions for the use of the oral-dental composition according to the invention may be a manual or a notice which may have the function in particular of explaining to the user the manner and frequency of application of the composition of said present invention.

[0154] The cosmetic care kit may also comprise an applicator, for example a dynamic applicator, for example manual or electric, for example a brushing device, for example a manual or electric toothbrush.

[0155] Other advantages may still appear to those skilled in the art upon reading the examples below, given for illustrative purposes.

[0156] Example 1: examples of oral compositions in the form of toothpaste

[0157] The example below describes different examples of compositions (tables 1 to 4) according to the invention in the form of toothpaste.

[0158] Table 1: Oral composition in the form of toothpaste

[0159] [Tables 1] INCI name / name % by weight of the total composition Cellulose gum 2-3 Sodium alginate 0.3 - 0.6 Lauryl glucoside 1-3 Disodium cocoyl glutamate 1-3 Active 0.5 - 1 Chitosan & mandelic acid 0.05 - 0.15 Nicomethanol hydrofluoride 5.17 Abrasive 0.5-4 Aroma 0.1 - 1.5 Color 0.001 - 0.1 Sweetener 0.01 - 1 Preservative 0.1 - 1 Glycerin 10-30 Sorbitol / Hydrogenated starch hydrolysate, aqua QSP 100% Aqua 10-30

[0160] Table 2: Oral composition in the form of toothpaste

[0161] [Tables2] INCI name / name % by weight of the total composition Cellulose gum 1 - 1.8 Sodium alginate 0.3 - 0.6 Lauryl glucoside 1-3 Disodium cocoyl glutamate 1-3 Chitosan & mandelic acid 0.05-0.15 Nicomethanol hydrofluoride 5 Abrasive 2-3 Aroma 0.3 - 1.5 Sweetener 0.1 -0.5 Water 10-30 Glycerin QSP 100%

[0162] Table 3: Oral composition in the form of toothpaste

[0163] [Tables3] INCI name / name % by weight of the total composition Cellulose gum 1 - 1.8 Sodium alginate 0.3 - 0.6 Lauryl glucoside 1-3 Disodium cocoyl glutamate 1-3 Chitosan & mandelic acid 0.05-0.1 Preservative 0.05 - 0.2 Nicomethanol hydrofluoride 5 Sweetener 0.05-0.1 Aroma 0.1 - 1 Glycerin Qsp 100% Water 20-30

[0164] Table 4: oral composition in the form of a green, shiny, odorous gel

[0165] [Tables4] INCI name / name % by weight of the total composition Cellulose gum 1.5-2 Sodium alginate 0.3 - 0.4 Abrasive 0.5-1 Lauryl glucoside 1.5-2 Disodium cocoyl glutamate 1 - 1.5 Chitosan & mandelic acid 0.1-0.2 Nicomethanol hydrofluoride 1.786 Sweetener 0.01 - 0.5 Aroma 0.1 - 1 Sorbitol / Hydrogenated starch hydrolysate, aqua Qsp 100% Colours 0.001 - 1 Glycerin 8 - 15 Preservative 0.05 - 0.5 Water 15-25

[0166] In the present example, the composition described in Table 4 below was prepared according to the general method comprising the following steps: a. preparation of a mixture A comprising at least one thickener, for example cellulose gum and / or sodium alginate, and glycerin (humectant). b. Homogenization of said mixture A by stirring with a Rayneri paddle stirrer or by magnetic stirring c. Preparation of a mixture B comprising at least one foaming agent, for example lauryl glucoside and / or disodium cocoyl glutamate and optionally at least one colorant d. In a main reactor, namely a glass beaker of suitable size, introduce sorbitol, for example in the form of hydrogenated starch hydrolysate, purified water and a film-forming agent, for example chitosan mandelate e. Stir using a Rayneri paddle stirrer for at least less than 30 min at room temperature, i.e. 20°C in order to obtain a homogeneous mixture C, f. Optionally adding at least one preservative to mixture C, and at least one sweetener, g. Introduction of the fluorine salt into mixture C and stirring for homogenization, for example for at least 10 min, for example for at least 15 minutes, and obtaining a mixture D, h. Introduction of mixture A with stirring for at least 15 min until complete homogenization of the final formula. The step of introducing mixture A may be prior or subsequent to the step of introducing the abrasive load, i. Introduction of the abrasive load into the mixture D and stirring, for example for at least 15 minutes, until completely homogenized and a mixture F is obtained, j. Introduction of mixture B with stirring for at least 15 min until complete homogenization of the final formula.

[0167] For example, the composition described in Table 4, in the main reactor, namely a glass beaker of suitable size, sorbitol (Hydrogenated starch hy-drolysate, aqua), purified water and chitosan mandelate were added. The whole was stirred using a Rayneri paddle stirrer until completely homogenized at room temperature, namely 20°C. Once the mixture was homogeneous, translucent without agglomerates, in the mixture the sweetener, the preservative, the colorants and the nicomethanol hydrofluoride were solubilized. In an additional reactor, namely a glass beaker, a sodium carmellose gel ("cellulose gum") and sodium alginate with glycerin was prepared and stirred using a Rayneri paddle stirrer until completely homogeneous.

[0168] In the main reactor, the gel previously prepared above was prepared. Then the abrasive was added and stirring at 800 rpm was maintained for at least 15 minutes to have a perfect dispersion of the powder.

[0169] While stirring, the aroma was added and finally the foaming agents, for example lauryl glucoside and disodium cocoyl glutamate, were added. The resulting composition was a shiny, homogeneous toothpaste.

[0170] Example 2: examples of oral compositions in the form of mouthwash

[0171] The example below describes an example of an oral-dental composition (Table 5) according to the invention in the form of toothpaste.

[0172] Table 5: oral composition in the form of a green, shiny, odorous gel

[0173] [Tables5] INCI name / name %

[0174] Example 6: Study of the anti-biofilm effect of film-forming agent

[0175] In the example below, an evaluation of the anti-biofilm effect, in particular the inhibition of the adhesion of bacteria to a surface, of a film-forming agent was carried out.

[0176] In this example an in vitro test involving the use of film-forming agent with respect to bacterial adhesion was carried out. The bacteria used was Streptococcus mutons (S. mutons), strain CIP 103220T A / Material

[0177] The bacteria were cultured in a Columbia agar medium comprising 5% sheep red blood cells (Biomérieux) by incubation at 36 ± 1°C, under anaerobic conditions.

[0178] The saliva used was human saliva collected with the Salivette device (trademark) then centrifuged at 3600 rpm for 10 minutes, pooled and immediately filtered through a sterile 0.45 qm membrane.

[0179] The hydroxyapatite pellet corresponding to the support used had a diameter: 9.4mm, thickness: 1.8mm (Supplier: Clarkson Chromatography Products Inc, USA). The support was sterilized at 121°C for 15 to 20 minutes.

[0180] A neutralizing medium was used and included Tween 80, (10% by weight), saponin (2% by weight), lecithin. (2% by weight), sodium thiosulfate (0.5% by weight) and Trypcase Soy Broth (qsp 100% by weight (Laboratory Preparation)).

[0181] A modified biofilm medium or minimal medium used was prepared according to the method below. Preparation of the modified biofilm medium lOx (FeSO4, 7H2O 0.005g / L, Na2 HPO4 12.5g / L, KH2PO4 5 g / L, (NH4)2SO4 1g / L and glucose 0.5g / L - Preparation of the laboratory) addition of MgSO4 lOOx (20g / L - Laboratory preparation) diluted just before the tests to the concentration used (Modified Biofilm Broth, MBB).

[0182] The conditions for counting adherent or suspended cells were as follows: Schaedler Broth (Schaedler Agar), incubation for 72 hours at 36 ± 1°C, under anaerobic conditions, then counting of colony-forming units (CFU).

[0183] The film-forming agents used were Chitosan Mandelate (Chitosan & mandelic acid; chitosan MS, Kraeber & Co GmbH, Germany) at 0.1% or 0.05% and siliglycol (silicone) at 1%. B / Procedures

[0184] Evaluation of the adhesion of S. mutans on a surface

[0185] Steps before evaluation: - Preparation of hydroxyapatite pellets (supports) by covering them with human saliva (1 mL) for 16 hours at room temperature. - Preparation of the S. mutans inoculum with sterile distilled water at 108 CFU / mL - Homogenization of the compositions to be tested (see below) by shaking for 5 minutes before the test.

[0186] Treatment of hydroxyapatite pellets (supports) with compositions to be tested (comprising film-forming products, see below) and incubation with S. mutans: - the supports were deposited in microplate wells (24-well plates. 2 mL of different compositions comprising at least one film-forming agent, namely compositions comprising different concentrations of chitosan mandelate or 1% siliglycol, were added. The compositions were preheated to 32°C before addition. Distilled water was used as a control. Two hydroxyapatite pellets per condition (product / concentration) were treated to evaluate them over different incubation times, namely 2, 4, 8 or 24 hours. - After 1 minute of contact, the supports were removed without rinsing, then introduced into a new well containing 2 mL of MBB and 100 qL of S. mutans at 107 CFU / mL. For this incubation with S. mutans the film-forming agent present in the form of a film on the hydroxyapatite supports remains. The effect of the presence of the film-forming agent on the surface in the form of a film with respect to the adhesion of bacteria was then evaluated as described below: - The microplates were incubated for 1 h at 36 ± 1°C, under anaerobic conditions. The supernatant was then aspirated and replaced again with 2 mL of MBB and 100 qL of S. mutans at 107 CFU / mL. - A count of the aspirated supernatant was carried out for each condition (product / concentration) in order to detect a possible bactericidal effect of the products in dependent on the film-forming effect: reduction in the number of bacteria in the supernatant (planktonic cells) compared to the control well.

[0187] - The microplates were again incubated at 36 ± 1°C, under conditions anaerobic, for 2h, 4h, 8h and 24h. Incubation in MBB medium (minimal medium) allowed proliferation of bacteria only in conditions of adhesion to the support: in the medium, non-adherent cells survive, but do not proliferate (unlike adhering cells). In the presence of the film-forming agent, a study of the possible effect of this, particularly on adhesion, was studied. This involved studying whether a decrease in the adhesion of bacteria to the surface, namely to the surface of hydroxyapatite pellets (supports) was observed. In other words, a study of the possible inhibition of the adhesion of bacteria to the hydroxyapatite support compared to the control wells as a function of incubation time was carried out. - After each incubation time, the supports corresponding to the incubation time T were removed from their respective wells and rinsed 3 times with 2 mL of sterile distilled water. Then, each support was scraped in the presence of 2.5 mL of sterile distilled water. The suspensions and supports were homogenized by vortexing (30 seconds) and CFU counts were performed using Schaedler Broth (preparation of the different dilutions of the suspensions to include the dilution adapted to the number of CFU of the condition, inclusion of 1 mL of each dilution in Schaedler Broth). - A CFU count of the supernatant in different wells was also performed after each incubation time. This count was performed again as a control in order to detect a potential impact of the pretreatment on the inoculum, independent of the film-forming effect. - After a 72-hour incubation at 36 ± 1°C, under anaerobic conditions, the CFU were counted. For cells adherent to the support, namely the hydroxyapatite pellets, the CFU values ​​are expressed as Log CFU / pellet.

[0188] - The tests were carried out in duplicate. C / Results

[0189] The results obtained concerning the adhesion of bacteria on the surface as a function of incubation with the compositions are represented in Tables 6 and 8 below. a. In a first series, the compositions used corresponded to: - three compositions comprising a film-forming agent in purified water: Chitosan MS 0.1%: Chitosan mandelate (Chitosan & mandelic acid; chitosan MS) at 0.1% by weight relative to the total weight of the composition Chitosan MS 0.05%: Chitosan mandelate (Chitosan & mandelic acid; chitosan MS) at 0.05% by weight relative to the total weight of the composition Siliglycol 1%: Siliglycol (silicone) 1% by weight relative to the total weight of the composition - Control: purified water

[0190] The results obtained are shown in Table 6 below.

[0191] [Tableauxô] CFU on support: Hydroxyapatite pellet Log CFU / Support 2H 4H 8H Mean Standard deviation e Mean Standard deviation e Mean Standard deviation Control 4.16 0.05 4.46 0.18 5.07 0.15 Chitosan MS 0.1% 2.94 0.31 3.50 0.64 4.31 0.82 Chitosan MS 0.05% 3.26 0.80 3.39 1.12 5.38 0.81 Siliglycol 1% 4.40 0.23 4.61 0.02 5.58 0.37

[0192] As demonstrated in Table 6 above, a delay or inhibition of biofilm formation (adherent cells on support) was observed for the compositions comprising chitosan mandelate at 0.1% by weight and at 0.05% by weight. This delay or inhibition of bacterial development clearly and unexpectedly demonstrates a film-forming effect of chitosan mandelate with an effect on bacterial adhesion at these concentrations. When the composition comprises chitosan mandelate at a concentration of 0.1% by weight, a delay or inhibition of adhesion was observed for up to 8 hours of incubation. When the composition comprises chitosan mandelate at a concentration of 0.05% by weight, a delay or inhibition of adhesion was observed for up to 4 hours of incubation. The results obtained clearly demonstrate that incubation with a solution comprising 1% by weight of siliglycol has no effect on bacterial adhesion.

[0193] Two additional solutions comprising respectively Chitosan Mandelate (Chitosan & mandelic acid; chitosan MS) at 0.25% and 0.5% by weight relative to the total weight of the composition were used. The results obtained demonstrated a bactericidal effect of the composition, namely a reduction in the number of bacteria in the supernatant compared to control conditions. This bactericidal effect did not allow an independent quantitative evaluation of a possible film-forming effect. (results not provided).

[0194] As demonstrated, the results clearly and unexpectedly demonstrate that chitosan mandelate at the tested concentration advantageously makes it possible to delay or inhibit bacterial adhesion to a surface, for example to a hydroxyapatite surface. The results also clearly demonstrate that chitosan mandelate advantageously makes it possible to delay or inhibit biofilm formation on a surface, for example to a hydroxyapatite surface, by inhibiting bacterial adhesion to said surface.

[0195] b) In a second series of tests, a comparative test was carried out. The compositions used were:

[0196] - an example of an oral-dental composition according to the invention, namely toothpaste comprising 0.1% by weight of chitosan mandelate relative to the total weight of the composition, said composition being free of silicone (“Composition A”),

[0197] - an example of an oral-dental composition in the form of a toothpaste comprising a silicone, namely siliglycol as a film-forming agent at a concentration of 1% by weight relative to the total weight of the composition (“Composition B”), and

[0198] - a composition (“0.1% chitosan ms solution”) comprising mandelate of chitosan in purified water at a concentration of 0.1% by weight relative to the total weight, and

[0199] - an example of an oral-dental composition in the form of silicone-free toothpaste and without chitosan mandelate (“Composition A without film-forming agent”).

[0200] The compositions tested are described in Table 7 below. The concentrations mentioned in Table 7 are expressed as a percentage by weight relative to the total weight of the composition.

[0201] Table 7: tested compositions

[0202] [Tables?] Composition A Composition A without film-forming agent Composition B Solution 0.1% chitosan MS Humectant 45-70 45-70 45-59 Foaming agent 4-6 4-6 4-6 Thickener 2-6 2-6 10-15 Nico-methanol hydrofluoride 4-5 4-5 4-5 Chitosan mandelate 0.1 / / 0.1 Siliglycol / / 1 / Abrasive, Colorant, Aroma 2-6 2-6 2-6 Aqua 20-35 20-35 20-35 Qsp 100

[0203] Table 8 below represents the results of the anti-adhesion tests in Log CFU / Support carried out with each composition listed in Table 7. NT corresponds to the results obtained after incubation in the absence of compositions (control).

[0204] [Tables8] Log CFU / Support Incubation time 24H Mean Standard deviation Untreated control (NT) 4.91 0.26 Chitosan mandelate solution 0.1% 3.69 0.92 Composition B 3.24 0.58 Composition A 2.79 0.11 Composition A without film former 3.78 0.39

[0205] As demonstrated in Table 8 above, an example of a composition in the form of a toothpaste according to the invention advantageously and surprisingly makes it possible to inhibit bacterial adhesion to a surface. In addition, the results clearly demonstrate that the example of a composition in the form of a toothpaste makes it possible to reduce by a factor of 2.8 the quantity of bacteria adhered to the surface compared to the known composition, for example comprising a silicone as a film-forming agent. In other words, surprisingly, the anti-adhesion effect is 2.8 times greater for an example of an oral-dental composition according to the invention comprising 0.1% chitosan mandelate as a film-forming agent compared to a composition of the prior art comprising 1% siliglycol (silicone) as a film-forming agent.Furthermore, the results clearly demonstrate that the present invention makes it possible to obtain an anti-adhesion effect at least twice as high with a composition comprising a concentration of film-forming agent 10 times lower.

[0206] Example 7: Study of the remineralizing power and / or remineralization of teeth

[0207] In the present example, a study of the remineralization, in other words the remineralizing power, of a fluorine combination and a film-forming agent was carried out. A / Solution test

[0208] The aim is to test the remineralizing power of a fluoride salt solution in the presence of chitosan mandelate, in comparison with a fluoride salt solution without this product.

[0209] In this example the Nicomethanol Hydrofluoride came from Pierre Fabre Oral Care (France).

[0210] In this example, chitosan mandelate was the product sold under the name Chitosan MS by the company Kraeber & Co GmbH (Germany).

[0211] Two solutions were prepared in demineralized water: - Nicomethanol hydrofluoride solution 5% by weight relative to the total weight of the composition (1400 ppm) - Nicomethanol Fluorhydrate solution 5% by weight relative to the total weight of the composition (1400ppm) comprising 0.1% by weight relative to the total weight of the chitosan mandelate composition.

[0212] As a positive control, a prior art commercial mouthwash, namely the product sold under the name Eluday Sensibilité (Pierre Fabre Oral Care), not comprising chitosan mandelate, and comprising nicomethanol hydrofluoride at 225 ppm was used. Purified water was used as a negative control.

[0213] Human enamel samples were studied in a cyclic treatment model comprising treatment with the test products and storage in an artificial saliva solution. Time-of-flight (TIF) mass spectrometry analysis secondary ion mass spectrometry, TOF-SIMS) is performed to compare the fixation of fluoride on the surface and in the upper layers of the enamel: up to about 4pm deep (see below).

[0214] Human enamel samples were obtained from human molars (assessment on 3 teeth / condition) separated into samples using a diamond blade saw, embedded in epoxy resin and then polished.

[0215] Firstly, the polished enamel samples were subjected to 1% citric acid (pH 3.8) for 15 minutes. In other words, the polished enamel samples were incubated for 15 minutes in a solution comprising a concentration of 1% by weight of citric acid, the pH of the solution was pH 3.8. This step corresponds to an "early erosion" type demineralization, simulating the reality of the human oral environment, for example during food intake.

[0216] In a cyclic procedure, the samples were treated twice daily for 10 days (20 treatments in total) with the test product for 1 min and rinsed with deionized water. Between treatments, the human enamel samples were preserved in artificial saliva. The product preparations were renewed at each cycle.

[0217] Artificial saliva was prepared by mixing the following ingredients: ■ Mucin (pig stomach) 2.5 g / L ■ Sodium chloride 3.5 g / L ■ Potassium chloride 0.2 g / L ■ Calcium chloride dihydrate 0.2 g / L ■ Yeast extract 2.0 g / L ■ Beef extract 1.0 g / L ■ Proteose peptone 5.0 g / L then autoclaved for 15 min, at 121°C, then adding 1.25 mL of 40% urea, and

[0218] obtaining a solution corresponding to artificial saliva.

[0219] Time-of-flight secondary ion mass spectrometry (TOF-SIMS) is a very sensitive technique for analyzing the surface of a sample. This method allows analysis of the upper layers, for example down to a depth of 4 pm. In other words, the very first layers are examined (a few pm). Indeed, the use of a sputtering ion gun allows the removal of a surface and the subsequent analysis of a freshly opened "new" surface, generating depth profiling with a resolution of nm accuracy.

[0220] Depth profiling was performed by TOF-SIMS (M6, lontof, Germany) with a measuring area of ​​70x70 pm2 and a sputter time in English from 0 to 7000 seconds (s) to identify the fixation of fluoride (F) on the surface and in depth of the enamel.

[0221] The applied spraying time of 7000 seconds corresponds to a surface depth of about 4 to 4.5 qm. In general, a longer spraying time corresponds to a greater depth. For further interpretation and quantification, the average values ​​of the respective fluoride intensities (F ) were calculated for each sample between 500 and 7000 s, 1500 and 2500 s as well as 5000 and 7000 s (areas which represent layers of different depths).

[0222] Statistical evaluation was performed by one-way ANOVA and Bonferroni post-hoc test, as well as analysis of variance by Brown-Forsythe test.

[0223] Data were expressed as fluoride signal intensity of the averaged profile: average obtained from 3 samples, signal intensity expressed in counts (arbitrary units) over the selected sputter time (sputter time in seconds).

[0224] The results obtained from the depth profiling by TOF-SIMS are presented in Table 9 for the entire profile evaluated (500-7000 s) as well as for selected sputter time zones: 1500-2500 s and 5000-7000 s.

[0225] [Tables9] Spray time in seconds Intensity F 500-7000 s 1500-2500 s 5000-7000 s Commercial Mouthwash 98 + 94 102+113 48 + 47 5% Nicomethanol Hydrofluoride Solution (1400ppm) 137 138 + 9 136 94 496 + 140 325 933 + 1 145 5% Nicomethanol Hydrofluoride Solution (1400ppm) and 0.1% Chitosan Mandelate 221 949 + 86 120 497 656 + 165 061 8 888 + 1 255 Negative control water 4 4 3 Increase factor (5% Nicomethanol Hydrofluoride Solution including or not including chitosan mandelate) 1.62 5.27 9.53 ANOVA test p value (5% nicomethanol hydrofluoride solution including or not chitosan mandelate) 0.23 0.005 0.0000016

[0226] The results clearly demonstrate that the averaged profiles for all the products applied the F intensities are higher than the results obtained for the control group (water), clearly demonstrating a fixation of the fluoride in the enamel and therefore a remineralization.

[0227] The results also clearly demonstrate that the compositions in the form of a solution comprising 5% by weight of nicomethanol hydrofluoride allow the obtaining of intensities greater than the reference mouthwash (225 ppm F). This may mainly be a concentration effect: the greater the quantity of fluoride present in the tested solution, the greater the quantity of fluoride fixed on the enamel.

[0228] As demonstrated, for all compositions tested, the intensity decreases with increasing spray time corresponding to deeper layers in the enamel.

[0229] The results also clearly and surprisingly demonstrate that the presence of chitosan mandelate in the composition advantageously makes it possible to increase the F intensity, clearly demonstrating an increase in the fixation of the fluoride and therefore an increase in remineralization.

[0230] The results demonstrate that the average of the F signal obtained over the overall depth (500-7000 seconds) increases, when the composition includes chitosan mandelate, by 62%. The results also clearly demonstrate a significant increase in the F signal obtained for the analysis of the 1500 - 2500 s and 5000 - 7000 s spray time windows with an increase factor of 5.27 and 9.53, respectively. The largest difference (factor of about 10) is therefore observed in the 5000 - 7000 s area which corresponds to the deepest enamel layers examined.The results clearly and surprisingly demonstrate that an example of an oral-dental composition according to the invention comprising at least one film-forming agent chosen from the group comprising chitosan and / or its derivatives, and at least one fluorine salt, said composition being free of silicone, advantageously and surprisingly allows the remineralization of the teeth to be increased, for example it advantageously allows an increase in the incorporation of fluorine into the deeper regions of the enamel. Furthermore, even more surprisingly, the results were obtained with a composition comprising a very low concentration, namely 0.1% by weight of film-forming agent. B / Test in a toothpaste base

[0231] In this example, a test of the remineralizing power of the compositions described in Table 10 below was carried out. The compositions differ only in the fluorine salt present (NaF or nicomethanol hydrofluoride). The quantities of fluorine present in the compositions are identical (1400 ppm). The compositions tested are described in Table 10 below.

[0232] Table 10: Oral-dental compositions in the form of toothpaste

[0233] [Tables10] INCI name / name Composition A with amine fluoride (% by weight relative to total weight or ppm) Composition B with sodium fluoride (% by weight relative to total weight or ppm) Cellulose gum 2-3% 2-3% Sodium alginate 0.3 - 0.6% 0.3 - 0.6% Lauryl glucoside 1 - 3% 1-3% Disodium cocoyl glutamate 1 - 3% 1-3% Active 0.5 - 1% 0.5 - 1% Chitosan & mandelic acid 0.05-0.15% 0.05 - 0.15% Nico-methanol hydrofluoride 1400 ppm (5%) NaF 1400 ppm (0.31%) Abrasive 0.5 - 4% Aroma 0.1 - 1.5% 0.1 - 1.5% Color 0.001-0.1% 0.001 - 0.1% Sweetener 0.01 - 1% 0.01 - 1% Preservative 0.1-1% 0.1 - 1% Glycerin 10 - 30% 10 - 30% Sorbitol / Hydrogenated starch hydrolysate, aqua QSP 100% QSP 100% Water 10 - 30% 10 - 30%

[0234] Human enamel samples were studied in a cyclic treatment model comprising treatment with the test products and storage in artificial saliva solution. Time-of-flight secondary ion mass spectrometry (TOF-SIMS) analysis was performed to compare the fixation fluoride, and therefore remineralization, on the surface and in the upper layers of the enamel (approximately 3 pm depth).

[0235] The Material and Method correspond to that described above in Part A except for the preparation of the samples of the compositions in the form of toothpaste which were prepared as suspensions of toothpaste in demineralized water: 1 part of toothpaste to 2 parts of demineralized water, vol / vol to mimic the conditions of use. The treatment time in the cyclic treatment model of the human enamel samples, namely each human enamel sample treated twice a day for 10 days - 20 treatments in total - with the tested product, evaluation on 3 human enamel samples / tested product, was 2 min for each cycle.

[0236] For the interpretation of the results, the mean values ​​of the respective F intensities per sample (data expressed as fluoride signal intensity of the averaged profile: mean obtained from 3 samples, signal intensity expressed in counts (arbitrary units)) were calculated for the different depths: between 50 and 250 nm, 750 and 1500 nm as well as 2000 and 3000 nm. Measurements were carried out after 1 single treatment and after 20 treatments.

[0237] The results of the F intensities measured as a function of the different depths in the enamel selected after 1 single treatment are presented in Table 11.

[0238] Table 11: F- intensity measured after treatment

[0239] [Tableauxll] Depth in enamel in nm Intensity F 50-250 nm 750-1500 nm 2000-3000 nm Composition B (NaF toothpaste) 1583+ 189 661 +276 180 + 46 Composition A (Nicomethanol hydrofluoride toothpaste) 1433 + 281 449 + 73 229 + 74 Negative control water 166 + 86 33 + 13 25 + 11

[0240] The results of the F intensities measured as a function of the different depths in the enamel selected after 20 treatments are presented in Table 12.

[0241] Table 12: F intensity measured after 20 treatments

[0242] [Tablesl2] Depth in enamel in nm Intensity F 50-250 nm 750-1500 nm 2000-3000 nm Composition B (NaF toothpaste) 1092 + 168 357 + 125 113 + 20 Composition A (Nicomethanol hydrofluoride toothpaste) 1881 + 314 562 + 125 308 + 24 Negative control water 408 + 412 91 + 104 36 + 24 Increase factor (Nicomethanol Hydrofluoride toothpaste vs. NaF toothpaste) 1.72 1.57 2.72 ANOVA test p value Nicomethanol Hydrofluoride toothpaste vs. NaF toothpaste 0.007 0.031 0.000000137

[0243] As demonstrated in Table 12 above, a comparison of the intensities as a function of depth shows higher F intensities for both compositions in toothpaste form compared to the control group (water). The results obtained clearly demonstrate that the compositions, for example in toothpaste form, comprising chitosan fluoride and mandelate induce remineralization from the first treatment.

[0244] The results surprisingly demonstrate that after 20 treatments, the composition in the form of toothpaste comprising Nicomethanol Hydrofluoride demonstrates a significantly higher remineralizing power than the same base with NaF, for all depths analyzed. This difference is more accentuated for the deepest area analyzed.

[0245] The results clearly and surprisingly demonstrate that examples of oral-dental composition according to the invention comprising at least one film-forming agent chosen from the group comprising chitosan and / or its derivatives, and at least one fluorine salt, said composition being free of silicone, advantageously and surprisingly allows the remineralization of the teeth to be increased, for example it advantageously allows an increase in the incorporation of fluorine into the deeper regions of the enamel. Furthermore, even more surprisingly, the results were obtained with a composition comprising a very low concentration, namely 0.1% by weight of film-forming agent. In addition, the results demonstrate that the exemplary composition according to the invention comprising a fluorine salt or nicomethanol hydrofluoride and chitosan mandelate advantageously allows incorporation of fluoride into the enamel. Furthermore, the results demonstrate that exemplary compositions according to the invention comprising a fluorine salt or nicomethanol hydrofluoride and chitosan mandelate advantageously allow incorporation of fluoride into the enamel, and in particular in deeper regions, for example after several applications of the composition. The results also surprisingly demonstrate that the incorporation of fluoride was higher after several applications when the composition comprises nicomethanol hydrofluoride, compared with NaF as the fluoride source.

[0246] The results clearly and surprisingly demonstrate that an example of an oral-dental composition according to the invention comprising at least one film-forming agent chosen from the group comprising chitosan and / or its derivatives, and at least one fluorine salt, said composition being free of silicone, advantageously and surprisingly allows the remineralization and / or remineralization of the teeth to be increased, for example it advantageously allows an increase in the incorporation of fluorine into the enamel. REFERENCES

[0247] Reference 1: Gullo Augusto et al, Film-Forming Polymers for Tooth Erosion Prevention, Polymers 14 (2022): 4225

[0248] Reference 2: ISO 16128 standard published in September 2017

[0249] Reference 3: Recommendation 2011 / 696 / EU of 18 October 2011 of the European Commission

[0250] Référence 4 : Griffin WC, Classification of Surface-Active Agents by HLB, Journal of the Society of Cosmetic Chemists 1 (1949): 311

Claims

Claims

1. Oral-dental composition comprising at least one film-forming agent chosen from the group comprising chitosan and / or its derivatives, preferably chitosan mandelate, and at least one fluorine salt, said composition being free of silicone.

2. Composition according to claim 1, in which the concentration of said at least one film-forming agent is from 0.02 to 1% by weight relative to the total weight of the composition.

3. Composition according to claim 1 or 2, wherein the concentration of said at least one fluorine salt is from 1% to 10% by weight relative to the total weight of the composition.

4. A composition according to any one of claims 1 to 3, wherein the composition further comprises at least one humectant preferably selected from the group consisting of glycerol, sorbitol, polyethylene glycol, polypropylene glycol, propylene glycol, propane 1,3 diol and any mixture thereof.

5. Composition according to any one of claims 1 to 4, the composition further comprises at least one thickening agent

6. A composition according to any one of claims 1 to 5, wherein the composition further comprises at least one foaming agent with an HLB of from 3 to 8.

7. Composition according to any one of claims 1 to 6, wherein said at least one fluorine salt is selected from the group comprising potassium fluoride, tin fluoride, amine fluoride, sodium fluoride, preferably amine fluoride.

8. Composition according to any one of claims 1 to 7 in which said at least one fluorine salt is nico-methanol hydrofluoride.

9. Composition according to any one of claims 1 to 8, said composition being free of free calcium salt, preferably free of calcium carbonate and / or calcium hydrogen phosphate.

10. . Composition according to any one of claims 1 to 9 for its use in remineralizing teeth.

11. . A method of manufacturing an oral composition according to any one of claims 1 to 9 comprising the steps of: a) preparing an oral composition base, b) addition to the composition base prepared in step a) of at least one film-forming agent and at least one fluorine salt, c) recovery of the obtained oral-dental composition