Combining tumor treating fields with radiation treatment planning

Abstract

A computer-implemented method comprising: obtaining a three-dimensional model of a subject; identifying a radiation therapy region in the model for delivering radiation therapy to a tumor of the subject, the radiation therapy region comprising a first and second radiation therapy regions to respectively receive a first and second dosage of radiation therapy; identifying a tumor treating fields therapy region in the model for delivering tumor treating fields therapy to the tumor, the tumor treating fields therapy region comprising the first radiation therapy region; identifying a first dosage for the tumor treating fields therapy for the first radiation therapy region to compensate for the first dosage of radiation therapy being smaller than the second dosage of radiation therapy; and selecting one or more transducer layouts for delivering tumor treating fields to the subject based on the first dosage for the tumor treating fields therapy for the first radiation therapy region.

Description

Abstract A computer-implemented method includes: obtaining a three-dimensional model of a subject; identifying a radiotherapy region in the model for delivering radiotherapy to a tumor of the subject, the radiotherapy region including a first radiotherapy region and a second radiotherapy region for receiving a first dose and a second dose of radiotherapy, respectively; identifying a tumor therapeutic electric field (TTPF) region in the model for delivering TTPF to the tumor, the TTPF region including the first radiotherapy region; identifying a first dose of the TTPF for the first radiotherapy region to compensate for a first dose of radiotherapy being less than a second dose of radiotherapy; and selecting one or more transducer arrangements based on the first dose of the TTPF for the first radiotherapy region to deliver the TTPF to the subject.

Claims

CLAIMSWhat is claimed is:

1. A computer-implemented method for selecting at least one transducer layout for delivering tumor treating fields to a subject, the method comprising: obtaining a three-dimensional model of the subject, the model comprising voxels; identifying a radiation therapy region in the three-dimensional model of the subject for delivering radiation therapy to a tumor of the subject, the radiation therapy region comprising a first radiation therapy region to receive a first dosage of radiation therapy and a second radiation therapy region to receive a second dosage of radiation therapy, the first dosage of radiation therapy being smaller than the second dosage of radiation therapy; identifying a tumor treating fields therapy region in the three-dimensional model of the subject for delivering tumor treating fields therapy to the tumor of the subject, the tumor treating fields therapy region comprising the first radiation therapy region; identifying a first dosage for the tumor treating fields therapy for the first radiation therapy region to compensate for the first dosage of radiation therapy being smaller than the second dosage of radiation therapy; and selecting one or more transducer layouts for delivering tumor treating fields to the subject based on the first dosage for the tumor treating fields therapy for the first radiation therapy region.

2. The computer- implemented method of claim 1, wherein the first radiation therapy region corresponds to a region of the subject that is more sensitive to radiation therapy than a region of the subject corresponding to the second radiation therapy region.

3. The computer- implemented method of claim 1, wherein the first dosage of radiation therapy is below a first threshold for the first radiation therapy region, wherein the first threshold is based on minimizing radiation therapy side effects for the subject.

4. The computer- implemented method of claim 1, wherein the first radiation therapy region corresponds to a region of the subject that is more difficult to apply radiation therapy than a region of the subject corresponding to the second radiation therapy region.

5. The computer- implemented method of claim 1, wherein the first dosage of radiation therapy is 50% or less than and greater than 0% of the second dosage of radiation therapy.

6. The computer- implemented method of claim 1, wherein the first dosage for the tumor treating fields therapy for the first radiation therapy region is based on the first dosage of radiation therapy for the first radiation therapy region.

7. The computer- implemented method of claim 1, wherein the tumor treating fields therapy region in the three-dimensional model of the subject comprises a portion or all of the second radiation therapy region, wherein the method further comprises identifying a second dosage for the tumor treating fields therapy for the second radiation therapy region based on the second dosage of radiation therapy for the second radiation therapy region, and wherein selecting one or more transducer layouts for delivering tumor treating fields to the subject is further based on the second dosage for the tumor treating fields therapy for the second radiation therapy region.

8. The computer- implemented method of claim 1, wherein the tumor treating fields therapy region in the three-dimensional model of the subject comprises a portion or all the second radiation therapy region, wherein the method further comprises identifying a second dosage for the tumor treating fields therapy for the second radiation therapy region without regard to the second dosage of radiation therapy for the second radiation therapy region, and wherein selecting one or more transducer layouts for delivering tumor treating fields to the subject is further based on the second dosage for the tumor treating fields therapy for the second radiation therapy region.

9. The computer- implemented method of claim 1, wherein a combination of the first dosage for the tumor treating fields therapy for the first radiation therapy region and the first dosage of radiation therapy for the first radiation therapy region meets or exceeds a therapeutic dosage threshold for treating the tumor in the first radiation therapy region using radiation therapy alone, wherein the first dosage of radiation therapy for the first radiation therapy region is less than a therapeutic dosage threshold for treating the tumor in the first radiation therapy region using radiation therapy alone.

10. The computer- implemented method of claim 1, wherein the first dosage of radiation therapy is in energy / mass units, wherein the first dosage for the tumor treating fields therapy is in energy / volume units, andwherein identifying the first dosage for the tumor treating fields therapy for the first radiation therapy region comprises: determining an approximate equivalent first dosage of radiation therapy for the first radiation therapy region in energy / volume units; and determining the first dosage for the tumor treating fields therapy for the first radiation therapy region based on the approximate equivalent first dosage of radiation therapy for the first radiation therapy region.

11. The computer- implemented method of claim 1, wherein the first and second dosages of radiation therapy are in energy / mass units, wherein a cumulative dosage of the first dosage for the tumor treating fields therapy for the first radiation therapy region and the first dosage of radiation therapy for the first radiation therapy region is approximately equivalent to or greater than the second dosage of radiation therapy.

12. The computer- implemented method of claim 1, wherein at least one of the selected transducer layouts is capable of providing the first dosage for the tumor treating fields therapy for the first radiation therapy region and a second dosage of the tumor treating fields therapy for the second radiation therapy region, wherein the first dosage of the tumor treating fields therapy and the second dosage of the tumor treating fields therapy are different.

13. The computer- implemented method of claim 1, wherein at least one of the selected transducer layouts is capable of providing the first dosage for the tumor treatingfields therapy for the first radiation therapy region and capable of providing a different dosage for the tumor treating fields therapy to at least one other region of the subject.

14. An apparatus for selecting at least one transducer layout for delivering tumor treating fields to a subject, the apparatus comprising: one or more processors; and memory accessible by the one or more processors, the memory storing instructions that when executed by the one or more processors, cause the apparatus to: obtain a three-dimensional model of the subject, the model comprising voxels; identify a radiation therapy region in the three-dimensional model of the subject for delivering radiation therapy to a tumor of the subject, the radiation therapy region comprising a first radiation therapy region to receive a first dosage of radiation therapy, the first dosage of radiation therapy being smaller than a therapeutic threshold for treating the tumor in the first radiation therapy region; identify a tumor treating fields therapy region in the three-dimensional model of the subject for delivering tumor treating fields therapy to the tumor of the subject, the tumor treating fields therapy region comprising the first radiation therapy region; identify a first dosage for the tumor treating fields therapy for the first radiation therapy region, wherein combining the first dosage of radiation therapy and the first dosage for the tumor treating fields therapy in the first radiation therapy region meets or exceed a therapeutic threshold for treating the tumor in the first radiation therapy region; and select one or more transducer layouts for delivering tumor treating fields to the subject based on the first dosage for the tumor treating fields therapy for the first radiation therapy region.

15. A non-transitory processor readable medium containing a set of instructions thereon that when executed by a processor cause the processor to: obtain a three-dimensional model of the subject, the model comprising voxels; identify a radiation therapy region in the three-dimensional model of the subject for delivering radiation therapy to a tumor of the subject, the radiation therapy region comprising a first radiation therapy region to receive a first dosage of radiation therapy and a second radiation therapy region to receive a second dosage of radiation therapy, the first dosage of radiation therapy being less than the second dosage of radiation therapy; identify a tumor treating fields therapy region in the three-dimensional model of the subject for delivering tumor treating fields therapy to the tumor of the subject, the tumor treating fields therapy region comprising the first radiation therapy region; identify a first dosage for the tumor treating fields therapy for the first radiation therapy region based on the first dosage of radiation therapy for the first radiation therapy region; and select one or more transducer layouts for delivering tumor treating fields to the subject based on the first dosage for the tumor treating fields therapy for the second radiation therapy region.

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