Fusion tricyclic KRAS inhibitors

Abstract

Disclosed are compounds of Formula I, methods of using compounds that inhibit KRAS activity, and pharmaceutical compositions containing such compounds, which are useful for treating, preventing, or ameliorating diseases or disorders associated with KRAS activity, such as cancer.

Description

Technical field

[0001] Related application This application is related to U.S. Provisional Application No. 63 / 011,089, filed April 16, 2020 and U.S. Provisional Application No. 63 / 146,899, filed February 8, 2021, The contents of each are incorporated herein by reference in their entireties.

[0002] The present disclosure provides compounds as well as their compositions and methods of use. Compounds modulate KRAS activity and are useful in treating a variety of diseases, including cancer. [Background technology]

[0003] Ras proteins are part of a family of small GTPases, which are activated by growth factors and various extracellular stimuli. The Ras family regulates intracellular signaling pathways, which are involved in cell growth, migration, survival and differentiation. Activation of RAS proteins at the plasma membrane engages key effectors and initiates a cascade of intracellular signaling pathways within the cell, including the RAF and PI3K kinase pathways. Somatic mutations in RAS can lead to uncontrolled cell growth and malignant transformation, while RAS protein activation is tightly regulated in normal cells (Simanshu, D. et al. Cell 170.1). 2017):17-33).

[0004] The Ras family consists of three members, KRAS, NRAS and HRAS. RAS-mutant cancers account for about 25% of human cancers. KRAS is the most frequently mutated isoform, accounting for 85% of all RAS mutations, while NRAS and HRAS are mutations found in 12% and 3% of all RAS-mutant cancers, respectively ( Simanshu, D. et al. Cell 170.1 (2017):17-33). KRAS mutations are prevalent in pancreatic (97%), colorectal (44%), and lung (30%) cancers, the top three deadliest types (Cox, A.D. et al. Nat. Rev Drug Discov (2014) 13:828-51). The majority of RAS mutations occur at amino acid residues 12, 13, and 61. The frequency of specific mutations differs between RAS gene isoforms, with G12 and Q61 mutations prevalent in KRAS and NRAS, respectively, while G12, G13 and Q61 mutations occur most frequently in HRAS. Moreover, the spectrum of mutations in RAS isoforms differs between cancer types. For example, the KRAS G12D mutation predominates in pancreatic cancer (51%) followed by colorectal adenocarcinoma (45%) and lung cancer (17%), while the KRAS G12V mutation predominates in pancreatic cancer (30%) followed by It is associated with colorectal adenocarcinoma (27%) and lung adenocarcinoma (23%) (Cox, A.D. et al. Nat Rev Drug Discov (2014) 13:828-51). In contrast, the KRAS G12C mutation predominates in non-small cell lung cancer (NSCLC), accounting for 11-16% of lung adenocarcinoma as well as pancreatic cancer. and accounts for 2-5% of colorectal adenocarcinoma (Cox, A.D. et al. Nat. Rev. Drug Discov. (2014) 13:828-51). Genomic studies across hundreds of cancer cell lines have demonstrated that cancer cells containing KRAS mutations are highly dependent on KRAS function for cell growth and survival (McDonald, R. et al. Cell 170(2017):577-592). The role of mutated KRAS as an oncogenic driver is further supported by extensive in vivo experimental evidence that mutated KRAS is required for the development and maintenance of primary tumors in animal models (Cox, A.D. et al. Nat Rev Drug Discov (2014) 13:828-51).

[0005] Taken together, these findings suggest that KRAS mutations play an important role in human cancer; may be useful in therapeutic interventions. [Outline of the invention]

[0006] The present disclosure inter alia provides compounds of formula I: [formation] or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein.

[0007] The disclosure further provides pharmaceutical compositions comprising a compound of the disclosure, or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier or excipient.

[0008] The disclosure further provides a method of inhibiting KRAS activity comprising administering to an individual a compound of the disclosure or a pharmaceutically acceptable salt thereof. The disclosure also provides use of a compound described herein in the manufacture of a medicament for use in therapy. The disclosure also provides compounds described herein for use in therapy.

[0009] The disclosure further provides a method of treating a disease or disorder in a patient comprising administering to the patient a therapeutically effective amount of a compound of the disclosure or a pharmaceutically acceptable salt thereof. [Mode for carrying out the invention]

[0010] Compound In one aspect, the present specification provides compounds of Formula I: [formation] or a pharmaceutically acceptable salt thereof (In the formula, each [formation] independently represents a single or double bond; X is N or CR 7 is; Y is N or C; R. 1 is H, D, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl, 5-10 membered heteroaryl, halo, CN, OR a1 , SR a1 , C(O)R b1 , C(O)NR c1 R. d1 , C(O)OR a1 , OC(O)R b1 , OC(O)NR c1 R. d1 , NR c1 R. d1 , NR c1 C(O)R b1 , NR c1 C(O)OR a1 , NR c1 C(O)NR c1 R. d1 , NR c1 S(O)R b1 , NR c1 S(O) 2 R. b1 , NR c1 S(O) 2 NR c1 R. d1 , S(O)R b1 , S(O)NR c1 R. d1 , S(O) 2 R. b1 , S(O) 2 NR c1 R. d1 , and BR h1 R. i1 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; R. 2 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , OR a2 , SR a2 , C(O)R b2 , C(O)NR c2 R. d2 , C(O)OR a2 , OC(O)R b2 , OC(O)NR c2 R. d2 , NR c2 R. d2, NR c2 C(O)R b2 , NR c2 C(O)OR a2 , NR c2 C(O)NR c2 R. d2 , C(=NR e2 )R b2 , C(=NOR a2 )R b2 , C(=NR e2 )NR c2 R. d2 , NR c2 C(=NR e2 )NR c2 R. d2 , NR c2 C(=NR e2 )R b2 , NR c2 S(O)R b2 , NR c2 S(O) 2 R. b2 , NR c2 S(O) 2 NR c2 R. d2 , S(O)R b2 , S(O)NR c2 R. d2 , S(O) 2 R. b2 , S(O) 2 NR c2 R. d2 , and BR h2 R. i2 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 22 substituted with 1, 2, 3, or 4 substituents independently selected from; Cy 1 is C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl, and 5- to 10-membered heteroaryl, wherein the 4- to 10-membered heterocycloalkyl and 5- to 10-membered heteroaryl are each independently from at least one ring-forming carbon atom and N, O, and S; having 1, 2, 3, or 4 ring-forming heteroatoms selected as , N and S are optionally oxidized to form 5- to 10-membered heteroaryl and 4- to 10-membered heterocycloalkyl The ring-forming carbon atom is optionally substituted with oxo to form a carbonyl group, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 10 substituted with 1, 2, 3, or 4 substituents independently selected from; R. 3 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , OR f3 , SR a3 , C(O)R b3 , C(O)NR c3 R. d3 , C(O)OR a3 , OC(O)R b3 , OC(O)NR c3 R. d3 , NR c3 R. j3 , NR c3 C(O)R b3 , NR c3 C(O)OR a3 , NR c3 C(O)NR c3 R. d3 , C(=NR e3 )R b3 , C(=NOR a3 )R b3 , C(=NR e3 )NR c3 R. d3 , NR c3 C(=NR e3 )NR c3 R. d3 , NR c3 C(=NR e3 )R b3 , NR c3 S(O)R b3 , NR c3 S(O) 2 R. b3 , NR c3 S(O) 2 NR c3 R. d3 , S(O)R b3 , S(O)NR c3 R. d3 , S(O) 2 R. b3 , S(O) 2 NR c3 R. d3 , and BR h3 R. i3 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 30 substituted with 1, 2, 3, or 4 substituents independently selected from; [formation] is a single bond and Y is C, then YR 6 is selected from C=O and C=S; R. 4 is H, D, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 cycloalkyl, 4-6 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, halo, CN, OR a4 , SR a4 , C(O)R b4 , C(O)NR c4 R. d4 , C(O)OR a4 , OC(O)R b4 , OC(O)NR c4 R. d4 , NR c4 R. d4 , NR c4 C(O)R b4 , NR c4 C(O)OR a4 , NR c4 C(O)NR c4 R. d4 , NR c4 S(O)R b4 , NR c4 S(O) 2 R. b4 , NR c4 S(O) 2 NR c4 R. d4 , S(O)R b4 , S(O)NR c4 R. d4 , S(O) 2 R. b4 , S(O) 2 NR c4 R. d4 , and BR h4 R. i4 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl, 4-6 membered heterocycloalkyl, phenyl, and 5-6 membered heteroaryl are each optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; R. 5 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , OR a5 , SR a5 , C(O)R b5 , C(O)NRc5 R. d5 , C(O)OR a5 , OC(O)R b5 , OC(O)NR c5 R. d5 , NR c5 R. d5 , NR c5 C(O)R b5 , NR c5 C(O)OR a5 , NR c5 C(O)NR c5 R. d5 , C(=NR e5 )R b5 , C(=NOR a5 )R b5 , C(=NR e5 )NR c5 R. d5 , NR c5 C(=NR e5 )NR c5 R. d5 , NR c5 C(=NR e5 )R b5 , NR c5 S(O)R b5 , NR c5 S(O) 2 R. b5 , NR c5 S(O) 2 NR c5 R. d5 , S(O)R b5 , S(O)NR c5 R. d5 , S(O) 2 R. b5 , S(O) 2 NR c5 R. d5 , and BR h5 R. i5 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 50 substituted with 1, 2, 3, or 4 substituents independently selected from; [formation] is a double bond and Y is N, then R 4 and R 6 does not exist; [formation] is a double bond and Y is C, then R 4 does not exist; R. 6 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , OR a6 , SR a6 , C(O)R b6 , C(O)NR c6 R. d6 , C(O)OR a6 , OC(O)R b6 , OC(O)NR c6 R. d6 , NR c6 R. d6 , NR c6 C(O)R b6 , NR c6 C(O)OR a6 , NR c6 C(O)NR c6 R. d6 , C(=NR e6 )R b6 , C(=NOR a6 )R b6 , C(=NR e6 )NR c6 R. d6 , NR c6 C(=NR e6 )NR c6 R. d6 , NR c6 C(=NR e6 )R b6 , NR c6 S(O)R b6 , NR c6 S(O) 2 R. b6 , NR c6 S(O) 2 NR c6 R. d6 , S(O)R b6 , S(O)NR c6 R. d6 , S(O) 2 R. b6 , S(O) 2 NR c6 R. d6 , and BR h6 R. i6 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 60 substituted with 1, 2, 3, or 4 substituents independently selected from; R. 7 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , OR a7 , SR a7 , C(O)R b7 , C(O)NR c7 R. d7 , C(O)OR a7 , OC(O)R b7 , OC(O)NR c7 R. d7 , NR c7 R. d7 , NR c7 C(O)R b7 , NR c7 C(O)OR a7 , NR c7 C(O)NR c7 R. d7 , C(=NR e7 )R b7 , C(=NOR a7 )R b7 , C(=NR e7 )NR c7 R. d7 , NR c7 C(=NR e7 )NR c7 R. d7 , NR c7 C(=NR e7 )R b7 , NR c7 S(O)R b7 , NR c7 S(O) 2 R. b7 , NR c7 S(O) 2 NR c7 R. d7 , S(O)R b7 , S(O)NR c7 R. d7 , S(O) 2 R. b7 , S(O) 2 NR c7 R. d7 , and BR h7 R. i7 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 70 substituted with 1, 2, 3, or 4 substituents independently selected from; Cy 2is C 3~10 cycloalkyl, 4-14 membered heterocycloalkyl, C 6~10 aryl, and 5- to 10-membered heteroaryl, wherein 4- to 14-membered heterocycloalkyl and 5- to 10-membered heteroaryl are each independently from at least one ring-forming carbon atom and N, O, and S; having 1, 2, 3, or 4 ring-forming heteroatoms selected as , N and S are optionally oxidized to 5- to 10-membered heteroaryl and 4- to 14-membered heterocycloalkyl The ring-forming carbon atom is optionally substituted with oxo to form a carbonyl group, C 3~10 cycloalkyl, 4-14 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 20 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 10 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , OR a10 , SR a10 , C(O)R b10 , C(O)NR c10 R. d10 , C(O)OR a10 , OC(O)R b10 , OC(O)NR c10 R. d10 , NR c10 R. d10 , NR c10 C(O)R b10 , NR c10 C(O)OR a10 , NR c10 C(O)NR c10 R. d10 , C(=NR e10 )R b10 , C(=NOR a10 )R b10 , C(=NR e10 )NR c10 R. d10 , NR c10 C(=NR e10 )NR c10 R. d10 , NR c10 S(O)R b10 , NR c10 S(O) 2 R. b10 , NR c10 S(O) 2 NR c10 R. d10 , S(O)R b10 , S(O)NR c10 R. d10 , S(O) 2 R. b10 , S(O) 2 NR c10 R. d10 , and BR h10 R. i10 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 11 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 11 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR a11 , SR a11 , C(O)R b11 , C(O)NR c11 R. d11 , C(O)OR a11 , OC(O)R b11 , OC(O)NR c11 R. d11 , NR c11 R. d11 , NR c11 C(O)R b11 , NR c11 C(O)OR a11 , NR c11 C(O)NR c11 R. d11 , NR c11 S(O)R b11 , NR c11 S(O) 2 R. b11 , NR c11 S(O) 2 NR c11 R. d11 , S(O)R b11 , S(O)NR c11 R. d11 , S(O) 2 R. b11 , S(O) 2 NR c11 R. d11 , and BR h11 R. i11 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 12 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 12 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a12 , SR a12 , C(O)R b12 , C(O)NR c12 R. d12 , C(O)OR a12 , OC(O)R b12 , OC(O)NR c12 R. d12 , NR c12 R. d12 , NR c12 C(O)R b12 , NR c12 C(O)OR a12 , NR c12 C(O)NR c12 R. d12 , NR c12 S(O)R b12 , NR c12 S(O) 2 R. b12 , NR c12 S(O) 2 NR c12 R. d12 , S(O)R b12 , S(O)NR c12 R. d12 , S(O) 2 R. b12 , S(O) 2 NR c12 R. d12 , and BR h12 R. i12 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 20 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , OR a20 , SR a20 , C(O)R b20 , C(O)NR c20 R. d20 , C(O)OR a20 , OC(O)R b20 , OC(O)NR c20 R. d20 , NR c20 R. d20 , NR c20 C(O)R b20 , NR c20 C(O)OR a20 , NR c20 C(O)NR c20 R. d20 , C(=NR e20 )R b20 , C(=NOR a20 )R b20 , C(=NR e20 )NR c20 R. d20 , NR c20 C(=NR e20 )NR c20 R. d20 , NR c20 S(O)R b20 , NR c20 S(O) 2 R. b20 , NR c20 S(O) 2 NR c20 R. d20 , S(O)R b20 , S(O)NR c20 R. d20 , S(O) 2 R. b20 , S(O) 2 NR c20 R. d20 , and BR h20 R. i20 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 21 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 21 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR a21 , SR a21 , C(O)R b21 , C(O)NR c21 R. d21 , C(O)OR a21 , OC(O)R b21 , OC(O)NR c21 R. d21 , NR c21 R. d21 , NR c21 C(O)R b21 , NR c21 C(O)OR a21 , NR c21 C(O)NR c21 R. d21 , NR c21 S(O)R b21 , NR c21 S(O) 2 R. b21 , NR c21 S(O) 2 NR c21 R. d21 , S(O)R b21 , S(O)NR c21 R. d21 , S(O) 2 R. b21 , S(O) 2 NR c21 R. d21 , and BR h21 R. i21 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 22 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , OR a22 , SR a22 , C(O)R b22 , C(O)NR c22 R. d22 , C(O)OR a22 , OC(O)R b22 , OC(O)NR c22 R. d22 , NR c22 R. d22 , NR c22 C(O)R b22 , NR c22 C(O)OR a22 , NR c22 C(O)NR c22 R. d22 , NR c22 S(O)R b22 , NR c22 S(O) 2 R. b22 , NR c22 S(O) 2 NR c22 R. d22 , S(O)R b22 , S(O)NR c22 R. d22 , S(O) 2 R. b22 , S(O) 2 NR c22 R. d22 , and BR h22 R. i22 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 23 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 23 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR a23 , SR a23 , C(O)R b23 , C(O)NR c23 R. d23 , C(O)OR a23 , OC(O)R b23 , OC(O)NR c23 R. d23 , NR c23 R. d23 , NR c23 C(O)R b23 , NR c23 C(O)OR a23 , NR c23 C(O)NR c23 R. d23, NR c23 S(O)R b23 , NR c23 S(O) 2 R. b23 , NR c23 S(O) 2 NR c23 R. d23 , S(O)R b23 , S(O)NR c23 R. d23 , S(O) 2 R. b23 , S(O) 2 NR c23 R. d23 , and BR h23 R. i23 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 24 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 24 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a24 , SR a24 , C(O)R b24 , C(O)NR c24 R. d24 , C(O)OR a24 , OC(O)R b24 , OC(O)NR c24 R. d24 , NR c24 R. d24 , NR c24 C(O)R b24 , NR c24 C(O)OR a24 , NR c24 C(O)NR c24 R. d24 , NR c24 S(O)R b24 , NR c24 S(O) 2 R. b24 , NR c24 S(O) 2 NR c24 R. d24 , S(O)R b24 , S(O)NR c24 R. d24 , S(O) 2 R. b24 , S(O) 2 NR c24 R. d24 , and BR h24 R. i24 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 30 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , OR a30 , SR a30 , C(O)R b30 , C(O)NR c30 R. d30 , C(O)OR a30 , OC(O)R b30 , OC(O)NR c30 R. d30 , NR c30 R. d30 , NR c30 C(O)R b30 , NR c30 C(O)OR a30 , NR c30 C(O)NR c30 R. d30 , NR c30 S(O)R b30 , NR c30 S(O) 2 R. b30 , NR c30 S(O) 2 NR c30 R. d30 , S(O)R b30 , S(O)NR c30 R. d30 , S(O) 2 R. b30 , S(O) 2 NR c30 R. d30 , and BR h30 R. i30 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 31 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 31 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR a31 , SR a31 , C(O)R b31 , C(O)NR c31 R. d31 , C(O)OR a31 , OC(O)R b31 , OC(O)NR c31 R. d31 , NR c31 R. d31 , NR c31 C(O)R b31 , NR c31 C(O)OR a31 , NR c31 C(O)NR c31 R. d31 , NR c31 S(O)R b31 , NR c31 S(O) 2 R. b31 , NR c31 S(O) 2 NR c31 R. d31 , S(O)R b31 , S(O)NR c31 R. d31 , S(O) 2 R. b31 , S(O) 2 NR c31 R. d31 , and BR h31 R. i31 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 32 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 32 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a32 , SR a32 , C(O)R b32, C(O)NR c32 R. d32 , C(O)OR a32 , OC(O)R b32 , OC(O)NR c32 R. d32 , NR c32 R. d32 , NR c32 C(O)R b32 , NR c32 C(O)OR a32 , NR c32 C(O)NR c32 R. d32 , NR c32 S(O)R b32 , NR c32 S(O) 2 R. b32 , NR c32 S(O) 2 NR c32 R. d32 , S(O)R b32 , S(O)NR c32 R. d32 , S(O) 2 R. b32 , S(O) 2 NR c32 R. d32 , and BR h32 R. i32 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 50 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR a50 , SR a50 , C(O)R b50 , C(O)NR c50 R. d50 , C(O)OR a50 , OC(O)R b50 , OC(O)NR c50 R. d50 , NR c50 R. d50 , NR c50 C(O)R b50 , NR c50 C(O)OR a50 , NR c50 C(O)NR c50 R. d50 , NR c50 S(O)R b50 , NR c50 S(O) 2 R. b50 , NR c50 S(O) 2 NR c50 R. d50 , S(O)R b50 , S(O)NR c50 R. d50 , S(O) 2 R. b50 , S(O) 2 NR c50 R. d50 , and BR h50 R. i50 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 51 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 51 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 Cycloalkyl, C 6~10 aryl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a51 , SR a51 , C(O)R b51 , C(O)NR c51 R. d51 , C(O)OR a51 , OC(O)R b51 , OC(O)NR c51 R. d51 , NR c51 R. d51 , NR c51 C(O)R b51 , NR c51 C(O)OR a51 , NR c51 C(O)NR c51 R. d51 , NR c51 S(O)R b51 , NR c51 S(O) 2 R. b51 , NR c51 S(O) 2 NR c51 R. d51 , S(O)R b51 , S(O)NR c51 R. d51 , S(O) 2 R. b51 , S(O) 2 NR c51 R. d51 , and BR h51 R. i51 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl, C 6~10 Aryl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally R 52 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 52 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a52 , SR a52 , C(O)R b52 , C(O)NR c52 R. d52 , C(O)OR a52 , OC(O)R b52 , OC(O)NR c52 R. d52 , NR c52 R. d52 , NR c52 C(O)R b52 , NR c52 C(O)OR a52 , NR c52 C(O)NR c52 R. d52 , NR c52 S(O)R b52 , NR c52 S(O) 2 R. b52 , NR c52 S(O) 2 NR c52 R. d52 , S(O)R b52 , S(O)NR c52 R. d52 , S(O) 2 R. b52 , S(O) 2 NR c52 R. d52 , and BR h52 R. i52 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 60 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , OR a60 , SR a60 , C(O)R b60 , C(O)NR c60 R. d60 , C(O)OR a60, OC(O)R b60 , OC(O)NR c60 R. d60 , NR c60 R. d60 , NR c60 C(O)R b60 , NR c60 C(O)OR a60 , NR c60 C(O)NR c60 R. d60 , NR c60 S(O)R b60 , NR c60 S(O) 2 R. b60 , NR c60 S(O) 2 NR c60 R. d60 , S(O)R b60 , S(O)NR c60 R. d60 , S(O) 2 R. b60 , S(O) 2 NR c60 R. d60 , and BR h60 R. i60 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 70 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , OR a70 , SR a70 , C(O)R b70 , C(O)NR c70 R. d70 , C(O)OR a70 , OC(O)R b70 , OC(O)NR c70 R. d70 , NR c70 R. d70 , NR c70 C(O)R b70 , NR c70 C(O)OR a70 , NR c70 C(O)NR c70 R. d70 , NR c70 S(O)R b70 , NR c70 S(O) 2 R. b70 , NR c70 S(O) 2 NR c70 R. d70 , S(O)R b70 , S(O)NR c70 R. d70 , S(O) 2 R. b70 , S(O) 2 NR c70 R. d70 , and BR h70 R. i70 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 71 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 71 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR a71 , SR a71 , C(O)R b71 , C(O)NR c71 R. d71 , C(O)OR a71 , OC(O)R b71 , OC(O)NR c71 R. d71 , NR c71 R. d71 , NR c71 C(O)R b71 , NR c71 C(O)OR a71 , NR c71 C(O)NR c71 R. d71 , NR c71 S(O)R b71 , NR c71 S(O) 2 R. b71 , NR c71 S(O) 2 NR c71 R. d71 , S(O)R b71 , S(O)NR c71 R. d71 , S(O) 2 R. b71 , S(O) 2 NR c71 R. d71 , and BR h71 R. i71 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 72 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 72 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a72 , SR a72 , C(O)R b72 , C(O)NR c72 R. d72 , C(O)OR a72 , OC(O)R b72 , OC(O)NR c72 R. d72 , NR c72 R. d72 , NR c72 C(O)R b72 , NR c72 C(O)OR a72 , NR c72 C(O)NR c72 R. d72 , NR c72 S(O)R b72 , NR c72 S(O) 2 R. b72 , NR c72 S(O) 2 NR c72 R. d72 , S(O)R b72 , S(O)NR c72 R. d72 , S(O) 2 R. b72 , S(O) 2 NR c72 R. d72 , and BR h72 R. i72 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; R.a1 , R b1 , R c1 , and R d1 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c1 and R d1 together with the N atoms to which they are attached, the R g forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from; R. h1 and R i1 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h1 and R i1 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a2 , R b2 , R c2 , and R d2 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 22 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c2 and R d2 together with the N atoms to which they are attached, the R 22 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; Each R e2 is H, CN, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 1~6 alkylthio, C 1~6 alkylsulfonyl, C 1~6 alkylcarbonyl, C 1~6 alkylaminosulfonyl, carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, aminosulfonyl, C 1~6 alkylaminosulfonyl, and di(C 1~6 independently selected from alkyl)aminosulfonyl; R. h2 and R i2 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h2 and R i2 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a3 , R b3 , R c3 , and R d3 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 30 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c3 and R d3 together with the N atoms to which they are attached, the R 30 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; Each R e3 is H, CN, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 1~6 alkylthio, C 1~6 alkylsulfonyl, C 1~6 alkylcarbonyl, C 1~6 alkylaminosulfonyl, carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, aminosulfonyl, C 1~6 alkylaminosulfonyl, and di(C 1~6 independently selected from alkyl)aminosulfonyl; R. f3 and R j3 are respectively C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 30 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c3 and R j3 together with the N atoms to which they are attached, the R 30 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R. h3 and R i3 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h3 and R i3 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a4 , R b4 , R c4 , and R d4 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c4 and R d4 together with the N atoms to which they are attached, the R gforming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from; R. h4 and R i4 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h4 and R i4 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a5 , R b5 , R c5 , and R d5 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 50 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c5 and R d5 together with the N atoms to which they are attached, the R 50 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; Each R e5 is H, CN, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 1~6 alkylthio, C 1~6 alkylsulfonyl, C 1~6 alkylcarbonyl, C 1~6 alkylaminosulfonyl, carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, aminosulfonyl, C 1~6 alkylaminosulfonyl, and di(C 1~6 independently selected from alkyl)aminosulfonyl; R. h5 and R i5 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h5 and R i5 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a6 , R b6 , R c6 , and R d6 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 60 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c6 and R d6 together with the N atoms to which they are attached, the R 60 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; Each R e6 is H, CN, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 1~6 alkylthio, C 1~6 alkylsulfonyl, C 1~6 alkylcarbonyl, C 1~6 alkylaminosulfonyl, carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, aminosulfonyl, C 1~6 alkylaminosulfonyl, and di(C 1~6 independently selected from alkyl)aminosulfonyl; R. h6 and R i6 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h6 and R i6 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a7 , R b7 , R c7 , and R d7 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 70 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c7 and R d7 together with the N atoms to which they are attached, the R 70 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; Each R e7 is H, CN, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 1~6 alkylthio, C 1~6 alkylsulfonyl, C 1~6 alkylcarbonyl, C 1~6 alkylaminosulfonyl, carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, aminosulfonyl, C 1~6 alkylaminosulfonyl, and di(C 1~6 independently selected from alkyl)aminosulfonyl; R. h7 and R i7 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h7 and R i7 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a10 , R b10 , R c10 , and R d10 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 11substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c10 and R d10 together with the N atoms to which they are attached, the R 11 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; Each R e10 is H, CN, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 1~6 alkylthio, C 1~6 alkylsulfonyl, C 1~6 alkylcarbonyl, C 1~6 alkylaminosulfonyl, carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, aminosulfonyl, C 1~6 alkylaminosulfonyl, and di(C 1~6 independently selected from alkyl)aminosulfonyl; R. h10 and R i10 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h10 and R i10 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a11 , R b11 , R c11 , and R d11 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 is independently selected from cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally R 12 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c11 and R d11 together with the N atoms to which they are attached, the R 12 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from; R. h11 and R i11 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h11 and R i11 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a12 , R b12 , R c12 , and R d12 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, and C 1~6 independently selected from haloalkyl and C above 1~6 Alkyl, C 2~6 alkenyl, and C 2~6 Each alkynyl is optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; R. h12 and R i12 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h12 and R i12 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a20 , R b20 , R c20 , and R d20 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 21 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c20 and R d20 together with the N atoms to which they are attached, the R 21 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; Each R e20 is H, CN, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 1~6 alkylthio, C 1~6 alkylsulfonyl, C 1~6 alkylcarbonyl, C 1~6 alkylaminosulfonyl, carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, aminosulfonyl, C 1~6 alkylaminosulfonyl, and di(C 1~6 independently selected from alkyl)aminosulfonyl; R. h20 and R i20 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h20 and R i20 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a21 , R b21 , R c21 , and R d21 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 is independently selected from cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c21 and R d21 together with the N atoms to which they are attached, the R g forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from; R. h21 and R i21 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h21 and R i21 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a22 , R b22 , R c22 , and R d22 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 23 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c22 and R d22 together with the N atoms to which they are attached, the R 23 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R. h22 and R i22 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h22 and R i22 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a23 , R b23 , R c23 , and R d23 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 is independently selected from cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally R 24 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c23 and R d23 together with the N atoms to which they are attached, the R 24 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from; R. h23 and R i23 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h23 and R i23 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a24 , R b24 , R c24 , and R d24 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, and C 1~6 independently selected from haloalkyl and C above 1~6 Alkyl, C 2~6 alkenyl, and C 2~6 Each alkynyl is optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; R. h24 and R i24 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h24 and R i24 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a30 , R b30 , R c30 , and R d30 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 31 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c30 and R d30 together with the N atoms to which they are attached, the R 31 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R. h30 and R i30 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h30 and R i30 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a31 , R b31 , R c31 , and R d31 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 is independently selected from cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally R 32 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c31 and R d31 together with the N atoms to which they are attached, the R 32 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from; R. h31 and R i31 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h31 and R i31 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a32 , R b32 , R c32 , and R d32 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, and C 1~6 independently selected from haloalkyl and C above 1~6 Alkyl, C 2~6 alkenyl, and C 2~6 Each alkynyl is optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; R. h32 and R i32 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h32 and R i32 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a50 , R b50 , R c50 , and R d50 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 51 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c50 and R d50 together with the N atoms to which they are attached, the R 51 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from; R. h50 and R i50 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h50 and R i50 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a51 , R b51 , R c51 , and R d51 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 is independently selected from cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally R 52 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c51 and R d51 together with the N atoms to which they are attached, the R 52 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R. h51 and R i51 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h51 and R i51 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a52 , R b52 , R c52 , and R d52 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, and C 1~6 independently selected from haloalkyl and C above 1~6 Alkyl, C 2~6 alkenyl, and C 2~6 Each alkynyl is optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; R. h52 and R i52 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h52 and R i52 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a60 , R b60 , R c60 , and R d60 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c60 and R d60 together with the N atoms to which they are attached, the R g forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R. h60 and R i60 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h60 and R i60 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a70 , R b70 , R c70 , and R d70 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 71 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c70 and R d70 together with the N atoms to which they are attached, the R 71 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R. h70 and R i70 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h70 and R i70 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a71 , R b71 , R c71 , and R d71 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 is independently selected from cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6Cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally R 72 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c71 and R d71 together with the N atoms to which they are attached, the R 72 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from; R. h71 and R i71 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h71 and R i71 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a72 , R b72 , R c72 , and R d72 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, and C 1~6 independently selected from haloalkyl and C above 1~6 Alkyl, C 2~6 alkenyl, and C 2~6 Each alkynyl is optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; R. h72 and R i72 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h72 and R i72 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; Each R g is D, OH, NO 2 , CN, halo, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 Cycloalkyl, C 3~6 Cycloalkyl-C 1~2 Alkylene, C 1~6 Alkoxy, C 1~6 haloalkoxy, C 1~3 Alkoxy-C 1~3 Alkyl, C 1~3 Alkoxy-C 1~3 Alkoxy, HO-C 1~3 Alkoxy, HO-C 1~3 Alkyl, cyano-C 1~3 Alkyl, H 2 N-C 1~3 Alkyl, Amino, C 1~6 alkylamino, di(C 1~6 Alkyl)amino, thio, C 1~6 alkylthio, C 1~6 Alkylsulfinyl, C 1~6 alkylsulfonyl, carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, carboxy, C 1~6 alkylcarbonyl, C 1~6 Alkoxycarbonyl, C 1~6 Alkylcarbonylamino, C 1~6 Alkoxycarbonylamino, C 1~6 alkylcarbonyloxy, aminocarbonyloxy, C 1~6 alkylaminocarbonyloxy, di(C 1~6 Alkyl)aminocarbonyloxy, C 1~6 alkylsulfonylamino, aminosulfonyl, C 1~6 Alkylaminosulfonyl, di(C 1~6 Alkyl)aminosulfonyl, aminosulfonylamino, C 1~6 Alkylaminosulfonylamino, di(C 1~6 Alkyl)aminosulfonylamino, aminocarbonylamino, C 1~6 alkylaminocarbonylamino, and di(C 1~6 independently selected from alkyl)aminocarbonylamino; however, [formation] is a double bond and Y is N, then Cy 1 is other than 3,5-dimethylisoxazol-4-yl).

[0011] In another aspect, the present specification provides compounds of Formula I: [formation] or a pharmaceutically acceptable salt thereof (In the formula, each [formation] independently represents a single or double bond; X is N or CR 7 is; Y is N or C; R. 1 is H, D, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl, 5-10 membered heteroaryl, halo, CN, OR a1 , SR a1 , C(O)R b1 , C(O)NR c1 R. d1 , C(O)OR a1 , OC(O)R b1 , OC(O)NR c1 R. d1 , NR c1 R. d1 , NR c1 C(O)R b1 , NR c1 C(O)OR a1 , NR c1 C(O)NR c1 R. d1 , NR c1 S(O)R b1 , NR c1 S(O) 2 R. b1 , NR c1 S(O) 2 NR c1 R. d1 , S(O)R b1 , S(O)NR c1 R. d1 , S(O) 2 R. b1 , S(O) 2 NR c1 R. d1 , and BR h1 R. i1 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; R. 2 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , OR a2 , SR a2 , C(O)R b2 , C(O)NR c2 R. d2 , C(O)OR a2 , OC(O)R b2 , OC(O)NR c2 R. d2 , NR c2 R. d2 , NR c2 C(O)R b2 , NR c2 C(O)OR a2 , NR c2 C(O)NR c2 R. d2 , C(=NR e2 )R b2 , C(=NOR a2 )R b2 , C(=NR e2 )NR c2 R. d2 , NR c2 C(=NRe2 )NR c2 R. d2 , NR c2 C(=NR e2 )R b2 , NR c2 S(O)R b2 , NR c2 S(O) 2 R. b2 , NR c2 S(O) 2 NR c2 R. d2 , S(O)R b2 , S(O)NR c2 R. d2 , S(O) 2 R. b2 , S(O) 2 NR c2 R. d2 , and BR h2 R. i2 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 22 substituted with 1, 2, 3, or 4 substituents independently selected from; Cy 1 is C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl, and 5- to 10-membered heteroaryl, wherein the 4- to 10-membered heterocycloalkyl and 5- to 10-membered heteroaryl are each independently from at least one ring-forming carbon atom and N, O, and S; having 1, 2, 3, or 4 ring-forming heteroatoms selected as , N and S are optionally oxidized to form 5- to 10-membered heteroaryl and 4- to 10-membered heterocycloalkyl The ring-forming carbon atom is optionally substituted with oxo to form a carbonyl group, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 10 substituted with 1, 2, 3, or 4 substituents independently selected from; R. 3 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , OR f3 , SR a3 , C(O)R b3 , C(O)NR c3 R. d3 , C(O)OR a3 , OC(O)R b3 , OC(O)NR c3 R. d3 , NR c3 R. j3 , NR c3 C(O)R b3 , NR c3 C(O)OR a3 , NR c3 C(O)NR c3 R. d3 , C(=NR e3 )R b3 , C(=NOR a3 )R b3 , C(=NR e3 )NR c3 R. d3 , NR c3 C(=NR e3 )NR c3 R. d3 , NR c3 C(=NR e3 )R b3 , NR c3 S(O)R b3 , NR c3 S(O) 2 R. b3 , NR c3 S(O) 2 NR c3 R. d3 , S(O)R b3 , S(O)NR c3 R. d3 , S(O) 2 R. b3 , S(O) 2 NR c3 R. d3 , and BR h3 R. i3 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 30 substituted with 1, 2, 3, or 4 substituents independently selected from; [formation] is a single bond and Y is C, then YR 6 is selected from C=O and C=S; R. 4 is H, D, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 cycloalkyl, 4-6 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, halo, CN, OR a4 , SR a4 , C(O)R b4 , C(O)NR c4 R. d4 , C(O)OR a4 , OC(O)R b4 , OC(O)NR c4 R. d4 , NR c4 R. d4 , NR c4 C(O)R b4 , NR c4 C(O)OR a4 , NR c4 C(O)NR c4 R. d4 , NR c4 S(O)R b4 , NR c4 S(O) 2 R. b4 , NR c4 S(O) 2 NR c4 R. d4 , S(O)R b4 , S(O)NR c4 R. d4 , S(O) 2 R. b4 , S(O) 2 NR c4 R. d4 , and BR h4 R. i4 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl, 4-6 membered heterocycloalkyl, phenyl, and 5-6 membered heteroaryl are each optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; R. 5 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , OR a5 , SR a5 , C(O)R b5 , C(O)NR c5 R. d5 , C(O)OR a5 , OC(O)R b5 , OC(O)NR c5 R. d5 , NR c5 R. d5 , NR c5 C(O)R b5 , NR c5 C(O)OR a5 , NR c5 C(O)NR c5 R. d5 , C(=NR e5)R b5 , C(=NOR a5 )R b5 , C(=NR e5 )NR c5 R. d5 , NR c5 C(=NR e5 )NR c5 R. d5 , NR c5 C(=NR e5 )R b5 , NR c5 S(O)R b5 , NR c5 S(O) 2 R. b5 , NR c5 S(O) 2 NR c5 R. d5 , S(O)R b5 , S(O)NR c5 R. d5 , S(O) 2 R. b5 , S(O) 2 NR c5 R. d5 , and BR h5 R. i5 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 50 substituted with 1, 2, 3, or 4 substituents independently selected from; [formation] is a double bond and Y is N, then R 4 and R 6 does not exist; [formation] is a double bond and Y is C, then R 4 does not exist; R. 6 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , OR a6 , SR a6 , C(O)R b6 , C(O)NR c6 R. d6 , C(O)OR a6 , OC(O)R b6 , OC(O)NR c6 R. d6 , NR c6 R. d6 , NR c6 C(O)R b6 , NR c6 C(O)OR a6 , NR c6 C(O)NR c6 R. d6 , C(=NR e6 )R b6 , C(=NOR a6 )R b6 , C(=NR e6 )NR c6 R. d6 , NR c6 C(=NR e6 )NR c6 R. d6 , NR c6 C(=NR e6 )R b6 , NR c6 S(O)R b6 , NR c6 S(O) 2 R. b6 , NR c6 S(O) 2 NR c6 R. d6 , S(O)R b6 , S(O)NR c6 R. d6 , S(O) 2 R. b6 , S(O) 2 NR c6 R. d6 , and BR h6 R. i6 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 60 substituted with 1, 2, 3, or 4 substituents independently selected from; R. 7 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , OR a7 , SR a7 , C(O)R b7 , C(O)NR c7 R. d7 , C(O)OR a7 , OC(O)R b7 , OC(O)NR c7 R. d7 , NR c7 R. d7 , NR c7 C(O)R b7 , NR c7 C(O)OR a7 , NR c7 C(O)NR c7 R. d7 , C(=NR e7 )R b7 , C(=NOR a7 )R b7 , C(=NR e7 )NR c7 R. d7 , NR c7 C(=NR e7 )NR c7 R. d7 , NR c7 C(=NR e7 )R b7 , NR c7 S(O)R b7 , NR c7 S(O) 2 R. b7 , NR c7 S(O) 2 NR c7 R. d7 , S(O)R b7 , S(O)NR c7 R. d7 , S(O) 2 R. b7 , S(O) 2 NR c7 R. d7 , and BR h7 R. i7 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 70 substituted with 1, 2, 3, or 4 substituents independently selected from; Cy 2 is C 3~10 cycloalkyl, 4-14 membered heterocycloalkyl, C 6~10aryl, and 5- to 10-membered heteroaryl, wherein 4- to 14-membered heterocycloalkyl and 5- to 10-membered heteroaryl are each independently from at least one ring-forming carbon atom and N, O, and S; having 1, 2, 3, or 4 ring-forming heteroatoms selected as , N and S are optionally oxidized to 5- to 10-membered heteroaryl and 4- to 14-membered heterocycloalkyl The ring-forming carbon atom is optionally substituted with oxo to form a carbonyl group, C 3~10 cycloalkyl, 4-14 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 20 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 10 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , OR a10 , SR a10 , C(O)R b10 , C(O)NR c10 R. d10 , C(O)OR a10 , OC(O)R b10 , OC(O)NR c10 R. d10 , NR c10 R. d10 , NR c10 C(O)R b10 , NR c10 C(O)OR a10 , NR c10 C(O)NR c10 R. d10 , C(=NR e10 )R b10 , C(=NOR a10 )R b10 , C(=NR e10 )NR c10 R. d10 , NR c10 C(=NR e10 )NR c10 R. d10 , NR c10 S(O)R b10 , NR c10 S(O) 2 R. b10 , NR c10 S(O) 2 NR c10 R. d10 , S(O)R b10 , S(O)NR c10 R. d10 , S(O) 2 R. b10 , S(O) 2 NR c10 R. d10 , and BR h10 R. i10 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 11 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 11 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR a11 , SR a11 , C(O)R b11 , C(O)NR c11 R. d11 , C(O)OR a11 , OC(O)R b11 , OC(O)NR c11 R. d11 , NR c11 R. d11 , NR c11 C(O)R b11 , NR c11 C(O)OR a11 , NR c11 C(O)NR c11 R. d11 , NR c11 S(O)R b11 , NR c11 S(O) 2 R. b11 , NR c11 S(O) 2 NR c11 R. d11 , S(O)R b11 , S(O)NR c11 R. d11 , S(O) 2 R. b11 , S(O) 2 NR c11 R. d11 , and BR h11 R. i11 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 12 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 12 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a12 , SR a12 , C(O)R b12 , C(O)NR c12 R. d12 , C(O)OR a12 , OC(O)R b12 , OC(O)NR c12 R. d12 , NR c12 R. d12 , NR c12 C(O)R b12 , NR c12 C(O)OR a12 , NR c12 C(O)NR c12 R. d12 , NR c12 S(O)R b12 , NR c12 S(O) 2 R. b12 , NR c12 S(O) 2 NR c12 R. d12 , S(O)R b12 , S(O)NR c12 R. d12 , S(O) 2 R. b12 , S(O) 2 NR c12 R. d12 , and BR h12 R. i12 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 20 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , ORa20 , SR a20 , C(O)R b20 , C(O)NR c20 R. d20 , C(O)OR a20 , OC(O)R b20 , OC(O)NR c20 R. d20 , NR c20 R. d20 , NR c20 C(O)R b20 , NR c20 C(O)OR a20 , NR c20 C(O)NR c20 R. d20 , C(=NR e20 )R b20 , C(=NOR a20 )R b20 , C(=NR e20 )NR c20 R. d20 , NR c20 C(=NR e20 )NR c20 R. d20 , NR c20 S(O)R b20 , NR c20 S(O) 2 R. b20 , NR c20 S(O) 2 NR c20 R. d20 , S(O)R b20 , S(O)NR c20 R. d20 , S(O) 2 R. b20 , S(O) 2 NR c20 R. d20 , and BR h20 R. i20 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 21 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 21 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR a21 , SR a21 , C(O)R b21 , C(O)NR c21 R. d21 , C(O)OR a21 , OC(O)R b21 , OC(O)NR c21 R. d21 , NR c21 R. d21 , NR c21 C(O)R b21 , NR c21 C(O)OR a21 , NR c21 C(O)NR c21 R. d21 , NR c21 S(O)R b21 , NR c21 S(O) 2 R. b21 , NR c21 S(O) 2 NR c21 R. d21 , S(O)R b21 , S(O)NR c21 R. d21 , S(O) 2 R. b21 , S(O) 2 NR c21 R. d21 , and BR h21 R. i21 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 22 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , OR a22 , SR a22 , C(O)R b22 , C(O)NR c22 R. d22 , C(O)OR a22 , OC(O)R b22 , OC(O)NR c22 R. d22 , NR c22 R. d22 , NR c22 C(O)R b22 , NR c22 C(O)OR a22 , NR c22 C(O)NR c22 R. d22 , NR c22 S(O)R b22 , NR c22 S(O) 2 R. b22 , NR c22 S(O) 2 NR c22 R. d22 , S(O)R b22 , S(O)NR c22 R. d22 , S(O) 2 R. b22 , S(O) 2 NR c22 R. d22 , and BR h22 R. i22 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 23 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 23 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR a23 , SR a23 , C(O)R b23 , C(O)NR c23 R. d23 , C(O)OR a23 , OC(O)R b23 , OC(O)NR c23 R. d23 , NR c23 R. d23 , NR c23 C(O)R b23 , NR c23 C(O)OR a23 , NR c23 C(O)NR c23 R. d23 , NR c23 S(O)R b23 , NR c23 S(O) 2R. b23 , NR c23 S(O) 2 NR c23 R. d23 , S(O)R b23 , S(O)NR c23 R. d23 , S(O) 2 R. b23 , S(O) 2 NR c23 R. d23 , and BR h23 R. i23 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 24 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 24 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a24 , SR a24 , C(O)R b24 , C(O)NR c24 R. d24 , C(O)OR a24 , OC(O)R b24 , OC(O)NR c24 R. d24 , NR c24 R. d24 , NR c24 C(O)R b24 , NR c24 C(O)OR a24 , NR c24 C(O)NR c24 R. d24 , NR c24 S(O)R b24 , NR c24 S(O) 2 R. b24 , NR c24 S(O) 2 NR c24 R. d24 , S(O)R b24 , S(O)NR c24 R. d24 , S(O) 2 R. b24 , S(O) 2 NR c24 R. d24 , and BR h24 R. i24 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 30 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , OR a30 , SR a30 , C(O)R b30 , C(O)NR c30 R. d30 , C(O)OR a30 , OC(O)R b30 , OC(O)NR c30 R. d30 , NR c30 R. d30 , NR c30 C(O)R b30 , NR c30 C(O)OR a30 , NR c30 C(O)NR c30 R. d30 , NR c30 S(O)R b30 , NR c30 S(O) 2 R. b30 , NR c30 S(O) 2 NR c30 R. d30 , S(O)R b30 , S(O)NR c30 R. d30 , S(O) 2 R. b30 , S(O) 2 NR c30 R. d30 , and BR h30 R. i30 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 31 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 31 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR a31 , SR a31 , C(O)R b31 , C(O)NR c31 R. d31 , C(O)OR a31 , OC(O)R b31 , OC(O)NR c31 R. d31 , NR c31 R. d31 , NR c31 C(O)R b31 , NR c31 C(O)OR a31 , NR c31 C(O)NR c31 R. d31 , NR c31 S(O)R b31 , NR c31 S(O) 2 R. b31 , NR c31 S(O) 2 NR c31 R. d31 , S(O)R b31 , S(O)NR c31 R. d31 , S(O) 2 R. b31 , S(O) 2 NR c31 R. d31 , and BR h31 R. i31 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 32 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 32 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a32 , SR a32 , C(O)R b32 , C(O)NR c32 R. d32 , C(O)OR a32 , OC(O)Rb32 , OC(O)NR c32 R. d32 , NR c32 R. d32 , NR c32 C(O)R b32 , NR c32 C(O)OR a32 , NR c32 C(O)NR c32 R. d32 , NR c32 S(O)R b32 , NR c32 S(O) 2 R. b32 , NR c32 S(O) 2 NR c32 R. d32 , S(O)R b32 , S(O)NR c32 R. d32 , S(O) 2 R. b32 , S(O) 2 NR c32 R. d32 , and BR h32 R. i32 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 50 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR a50 , SR a50 , C(O)R b50 , C(O)NR c50 R. d50 , C(O)OR a50 , OC(O)R b50 , OC(O)NR c50 R. d50 , NR c50 R. d50 , NR c50 C(O)R b50 , NR c50 C(O)OR a50 , NR c50 C(O)NR c50 R. d50 , NR c50 S(O)R b50 , NR c50 S(O) 2 R. b50 , NR c50 S(O) 2 NR c50 R. d50 , S(O)R b50 , S(O)NR c50 R. d50 , S(O) 2 R. b50 , S(O) 2 NR c50 R. d50 , and BR h50 R. i50 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 51 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 51 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 Cycloalkyl, C 6~10 aryl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a51 , SR a51 , C(O)R b51 , C(O)NR c51 R. d51 , C(O)OR a51 , OC(O)R b51 , OC(O)NR c51 R. d51 , NR c51 R. d51 , NR c51 C(O)R b51 , NR c51 C(O)OR a51 , NR c51 C(O)NR c51 R. d51 , NR c51 S(O)R b51 , NR c51 S(O) 2 R. b51 , NR c51 S(O) 2 NR c51 R. d51 , S(O)R b51 , S(O)NR c51 R. d51 , S(O) 2 R. b51 , S(O) 2 NR c51 R. d51 , and BR h51 R. i51 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl, C 6~10 Aryl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally R 52 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 52 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a52 , SR a52 , C(O)R b52 , C(O)NR c52 R. d52 , C(O)OR a52 , OC(O)R b52 , OC(O)NR c52 R. d52 , NR c52 R. d52 , NR c52 C(O)R b52 , NR c52 C(O)OR a52 , NR c52 C(O)NR c52 R. d52 , NR c52 S(O)R b52 , NR c52 S(O) 2 R. b52 , NR c52 S(O) 2 NR c52 R. d52 , S(O)R b52 , S(O)NR c52 R. d52 , S(O) 2 R. b52 , S(O) 2 NR c52 R. d52 , and BR h52 R. i52 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 60 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , OR a60 , SR a60 , C(O)R b60 , C(O)NR c60 R. d60 , C(O)OR a60 , OC(O)R b60 , OC(O)NR c60 R. d60 , NRc60 R. d60 , NR c60 C(O)R b60 , NR c60 C(O)OR a60 , NR c60 C(O)NR c60 R. d60 , NR c60 S(O)R b60 , NR c60 S(O) 2 R. b60 , NR c60 S(O) 2 NR c60 R. d60 , S(O)R b60 , S(O)NR c60 R. d60 , S(O) 2 R. b60 , S(O) 2 NR c60 R. d60 , and BR h60 R. i60 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 61 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 61 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR a61 , SR a61 , C(O)R b61 , C(O)NR c61 R. d61 , C(O)OR a61 , OC(O)R b61 , OC(O)NR c61 R. d61 , NR c61 R. d61 , NR c61 C(O)R b61 , NR c61 C(O)OR a61 , NR c61 C(O)NR c61 R. d61 , NR c61 S(O)R b61 , NR c61 S(O) 2 R. b61 , NR c61 S(O) 2 NR c61 R. d61 , S(O)R b61 , S(O)NR c61 R. d61 , S(O) 2 R. b61 , S(O) 2 NR c61 R. d61 , and BR h61 R. i61 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 62 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 62 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a62 , SR a62 , C(O)R b62 , C(O)NR c62 R. d62 , C(O)OR a62 , OC(O)R b62 , OC(O)NR c62 R. d62 , NR c62 R. d62 , NR c62 C(O)R b62 , NR c62 C(O)OR a62 , NR c62 C(O)NR c62 R. d62 , NR c62 S(O)R b62 , NR c62 S(O) 2 R. b62 , NR c62 S(O) 2 NR c62 R. d62 , S(O)R b62 , S(O)NR c62 R. d62 , S(O) 2 R. b62 , S(O) 2 NR c62 R. d62 , and BR h62 R. i62 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 70 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , OR a70 , SR a70 , C(O)R b70 , C(O)NR c70 R. d70 , C(O)OR a70 , OC(O)R b70 , OC(O)NR c70 R. d70 , NR c70 R. d70 , NR c70 C(O)R b70 , NR c70 C(O)OR a70 , NR c70 C(O)NR c70 R. d70 , NR c70 S(O)R b70 , NR c70 S(O) 2 R. b70 , NR c70 S(O) 2 NR c70 R. d70 , S(O)R b70 , S(O)NR c70 R. d70 , S(O) 2 R. b70 , S(O) 2 NR c70 R. d70 , and BR h70 R. i70 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 71 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 71 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR a71 , SR a71 , C(O)R b71 , C(O)NR c71 R. d71 , C(O)OR a71 , OC(O)R b71 , OC(O)NR c71 R. d71 , NR c71 R. d71 , NR c71 C(O)R b71 , NR c71 C(O)OR a71 , NR c71 C(O)NR c71 R. d71 , NR c71 S(O)R b71 , NR c71 S(O) 2 R. b71 , NR c71 S(O) 2 NR c71 R. d71 , S(O)R b71 , S(O)NR c71 R. d71 , S(O) 2 R. b71 , S(O) 2 NR c71 R. d71 , and BR h71 R. i71 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 72 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 72 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a72 , SR a72 , C(O)R b72 , C(O)NR c72 R. d72 , C(O)OR a72 , OC(O)R b72 , OC(O)NR c72 R. d72 , NR c72 R. d72 , NR c72 C(O)R b72 , NR c72 C(O)OR a72 , NR c72 C(O)NR c72 R. d72 , NR c72 S(O)R b72 , NR c72 S(O) 2 R. b72 , NR c72 S(O) 2 NR c72 R. d72 , S(O)R b72 , S(O)NR c72 R. d72 , S(O) 2 R. b72 , S(O) 2 NR c72 R. d72 , and BR h72 R. i72 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; R. a1 , R b1 , R c1 , and R d1 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c1 and R d1 together with the N atoms to which they are attached, the R g forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from; R. h1 and R i1 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h1 and R i1 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a2 , R b2 , R c2 , and R d2 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 22 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c2 and R d2 together with the N atoms to which they are attached, the R 22 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; Each R e2 is H, CN, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 1~6 alkylthio, C 1~6 alkylsulfonyl, C 1~6 alkylcarbonyl, C 1~6 alkylaminosulfonyl, carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, aminosulfonyl, C 1~6 alkylaminosulfonyl, and di(C 1~6 independently selected from alkyl)aminosulfonyl; R. h2 and R i2 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h2 and R i2 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a3 , R b3 , R c3 , and R d3 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 30 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c3 and R d3 together with the N atoms to which they are attached, the R 30 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; Each R e3 is H, CN, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 1~6 alkylthio, C 1~6 alkylsulfonyl, C 1~6 alkylcarbonyl, C 1~6 alkylaminosulfonyl, carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, aminosulfonyl, C 1~6 alkylaminosulfonyl, and di(C 1~6 independently selected from alkyl)aminosulfonyl; R. f3 and R j3 are respectively C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 30 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c3 and R j3 together with the N atoms to which they are attached, the R 30 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R. h3 and R i3 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h3 and R i3 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a4 , R b4 , R c4 , and R d4 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c4 and R d4 together with the N atoms to which they are attached, the R g forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from; R. h4 and R i4 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h4 and R i4 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a5 , R b5 , R c5 , and R d5 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 50 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c5 and R d5 together with the N atoms to which they are attached, the R 50 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; Each R e5 is H, CN, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 1~6 alkylthio, C 1~6 alkylsulfonyl, C 1~6 alkylcarbonyl, C 1~6 alkylaminosulfonyl, carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, aminosulfonyl, C 1~6 alkylaminosulfonyl, and di(C 1~6 independently selected from alkyl)aminosulfonyl; R. h5 and R i5 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h5 and R i5 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a6 , R b6 , R c6 , and R d6 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 60 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c6 and R d6 together with the N atoms to which they are attached, the R 60 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; Each R e6 is H, CN, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C1~6 alkylthio, C 1~6 alkylsulfonyl, C 1~6 alkylcarbonyl, C 1~6 alkylaminosulfonyl, carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, aminosulfonyl, C 1~6 alkylaminosulfonyl, and di(C 1~6 independently selected from alkyl)aminosulfonyl; R. h6 and R i6 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h6 and R i6 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a7 , R b7 , R c7 , and R d7 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 70 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c7 and R d7 together with the N atoms to which they are attached, the R 70 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; Each R e7 is H, CN, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 1~6 alkylthio, C 1~6 alkylsulfonyl, C 1~6 alkylcarbonyl, C 1~6 alkylaminosulfonyl, carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, aminosulfonyl, C 1~6 alkylaminosulfonyl, and di(C 1~6 independently selected from alkyl)aminosulfonyl; R. h7 and R i7 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h7 and R i7 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a10 , R b10 , R c10 , and R d10 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 11 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c10 and R d10 together with the N atoms to which they are attached, the R 11 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; Each R e10 is H, CN, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 1~6 alkylthio, C 1~6 alkylsulfonyl, C 1~6 alkylcarbonyl, C 1~6 alkylaminosulfonyl, carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, aminosulfonyl, C 1~6 alkylaminosulfonyl, and di(C 1~6 independently selected from alkyl)aminosulfonyl; R. h10 and R i10 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h10 and R i10 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a11 , R b11 , R c11 , and R d11 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 is independently selected from cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally R 12 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c11 and R d11 together with the N atoms to which they are attached, the R 12 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from; R. h11 and R i11 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h11 and R i11 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a12 , R b12 , R c12 , and R d12 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, and C 1~6 independently selected from haloalkyl and C above 1~6 Alkyl, C 2~6 alkenyl, and C 2~6 Each alkynyl is optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; R. h12 and R i12 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h12 and R i12 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a20 , R b20 , R c20 , and R d20are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 21 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c20 and R d20 together with the N atoms to which they are attached, the R 21 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; Each R e20 is H, CN, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 1~6 alkylthio, C 1~6 alkylsulfonyl, C 1~6 alkylcarbonyl, C 1~6 alkylaminosulfonyl, carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, aminosulfonyl, C 1~6 alkylaminosulfonyl, and di(C 1~6 independently selected from alkyl)aminosulfonyl; R. h20 and R i20 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h20 and R i20 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a21 , R b21 , R c21 , and R d21 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 is independently selected from cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c21 and R d21 together with the N atoms to which they are attached, the R g forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from; R. h21 and R i21 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h21 and R i21 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a22 , R b22 , R c22 , and R d22 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 23 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c22 and R d22 together with the N atoms to which they are attached, the R 23 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R. h22 and R i22 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h22 and R i22 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a23 , R b23 , R c23 , and R d23 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 is independently selected from cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally R 24 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c23 and R d23 together with the N atoms to which they are attached, the R 24 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from; R. h23 and R i23 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h23 and R i23 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a24 , R b24 , R c24 , and R d24 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, and C 1~6 independently selected from haloalkyl and C above 1~6 Alkyl, C 2~6 alkenyl, and C 2~6 Each alkynyl is optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; R. h24 and R i24 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h24 and R i24 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a30 , R b30 , R c30 , and R d30 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 31 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c30 and R d30 together with the N atoms to which they are attached, the R 31 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R. h30 and R i30 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h30 and R i30 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a31 , R b31 , R c31 , and R d31 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 is independently selected from cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally R 32 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c31 and R d31 together with the N atoms to which they are attached, the R 32 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from; R. h31 and R i31 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h31 and R i31 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a32 , R b32 , R c32 , and R d32 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, and C 1~6 independently selected from haloalkyl and C above 1~6 Alkyl, C 2~6 alkenyl, and C 2~6 Each alkynyl is optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; R. h32 and R i32 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h32 and R i32 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a50 , R b50 , R c50 , and R d50 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 51 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c50 and R d50 together with the N atoms to which they are attached, the R 51 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from; R. h50 and R i50 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h50 and R i50 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a51 , R b51 , R c51 , and R d51 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 is independently selected from cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally R 52 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c51 and R d51 together with the N atoms to which they are attached, the R 52 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R. h51 and R i51 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h51 and R i51 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a52 , R b52 , R c52 , and R d52 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, and C 1~6 independently selected from haloalkyl and C above 1~6 Alkyl, C 2~6 alkenyl, and C 2~6 Each alkynyl is optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; R. h52 and R i52 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h52 and R i52 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a60 , R b60 , R c60 , and R d60 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 61 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c60 and R d60 together with the N atoms to which they are attached, the R 61 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R. h60 and R i60 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h60 and R i60 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a61 , R b61 , R c61 , and R d61 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 is independently selected from cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally R 62 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c61 and R d61 together with the N atoms to which they are attached, the R 62 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from; R. h61 and R i61 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h61 and R i61 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a62 , R b62 , R c62 , and R d62 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, and C 1~6 independently selected from haloalkyl and C above 1~6 Alkyl, C 2~6 alkenyl, and C 2~6 Each alkynyl is optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c62 and R d62 together with the N atoms to which they are attached, the R g forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R. h62 and R i62 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h62 and R i62 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a70 , R b70 , R c70 , and R d70 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 71 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c70 and R d70 together with the N atoms to which they are attached, the R 71 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R. h70 and R i70 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h70 and R i70 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a71 , R b71 , R c71 , and R d71 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 is independently selected from cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally R 72 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c71 and R d71 together with the N atoms to which they are attached, the R 72 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from; R. h71 and R i71 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h71 and R i71 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a72 , R b72 , R c72 , and R d72 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, and C 1~6 independently selected from haloalkyl and C above1~6 Alkyl, C 2~6 alkenyl, and C 2~6 Each alkynyl is optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; R. h72 and R i72 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h72 and R i72 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; Each R g is D, OH, NO 2 , CN, halo, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 Cycloalkyl, C 3~6 Cycloalkyl-C 1~2 Alkylene, C 1~6 Alkoxy, C 1~6 haloalkoxy, C 1~3 Alkoxy-C 1~3 Alkyl, C 1~3 Alkoxy-C 1~3 Alkoxy, HO-C 1~3 Alkoxy, HO-C 1~3 Alkyl, cyano-C 1~3 Alkyl, H 2 N-C 1~3 Alkyl, Amino, C 1~6 alkylamino, di(C 1~6 Alkyl)amino, thio, C 1~6 alkylthio, C 1~6 Alkylsulfinyl, C 1~6 alkylsulfonyl, carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, carboxy, C 1~6 alkylcarbonyl, C 1~6 Alkoxycarbonyl, C 1~6 Alkylcarbonylamino, C 1~6 Alkoxycarbonylamino, C 1~6 alkylcarbonyloxy, aminocarbonyloxy, C 1~6 alkylaminocarbonyloxy, di(C 1~6 Alkyl)aminocarbonyloxy, C 1~6 alkylsulfonylamino, aminosulfonyl, C 1~6 Alkylaminosulfonyl, di(C 1~6 Alkyl)aminosulfonyl, aminosulfonylamino, C 1~6 Alkylaminosulfonylamino, di(C 1~6 Alkyl)aminosulfonylamino, aminocarbonylamino, C 1~6 alkylaminocarbonylamino, and di(C 1~6 independently selected from alkyl)aminocarbonylamino; however, [formation] is a double bond and Y is N, then Cy 1 is other than 3,5-dimethylisoxazol-4-yl).

[0012] In one embodiment of Formula I or a pharmaceutically acceptable salt thereof, each [formation] independently represents a single or double bond; X is N or CR 7 is; Y is N or C; R. 1 is H, D, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl, 5-10 membered heteroaryl, halo, CN, OR a1 , SR a1 , C(O)R b1 , C(O)NR c1 R. d1 , C(O)OR a1 , OC(O)R b1 , OC(O)NR c1 R. d1 , NR c1 R. d1 , NR c1 C(O)R b1 , NR c1 C(O)OR a1 , NR c1 C(O)NR c1 R. d1 , NR c1 S(O)R b1 , NR c1 S(O) 2 R. b1 , NR c1 S(O) 2 NR c1 R. d1 , S(O)R b1 , S(O)NR c1 R. d1 , S(O) 2 R. b1 , S(O) 2 NR c1 R. d1 , and BR h1 R. i1 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; R. 2 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , OR a2 , SR a2 , C(O)R b2 , C(O)NR c2 R. d2 , C(O)OR a2 , OC(O)R b2 , OC(O)NR c2 R. d2 , NR c2 R. d2 , NR c2 C(O)R b2 , NR c2 C(O)OR a2 , NR c2 C(O)NR c2 R. d2 , C(=NR e2 )R b2 , C(=NOR a2 )R b2 , C(=NR e2 )NR c2 R. d2 , NR c2 C(=NR e2 )NR c2 R. d2 , NR c2 C(=NR e2 )R b2 , NR c2 S(O)R b2 , NR c2 S(O) 2 R. b2 , NR c2 S(O) 2 NR c2 R. d2 , S(O)R b2 , S(O)NR c2 R. d2 , S(O) 2 R. b2 , S(O) 2 NR c2 R. d2 , and BR h2 R. i2 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 22 substituted with 1, 2, 3, or 4 substituents independently selected from; Cy 1 is C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10aryl, and 6- to 10-membered heteroaryl, wherein the 4- to 10-membered heterocycloalkyl and 6- to 10-membered heteroaryl are each independently from at least one ring-forming carbon atom and N, O, and S; having 1, 2, 3, or 4 ring-forming heteroatoms selected as , N and S are optionally oxidized to form 6- to 10-membered heteroaryl and 4- to 10-membered heterocycloalkyl The ring-forming carbon atom is optionally substituted with oxo to form a carbonyl group, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 6- to 10-membered heteroaryl are each optionally R 10 substituted with 1, 2, 3, or 4 substituents independently selected from; R. 3 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , OR f3 , SR a3 , C(O)R b3 , C(O)NR c3 R. d3 , C(O)OR a3 , OC(O)R b3 , OC(O)NR c3 R. d3 , NR c3 R. j3 , NR c3 C(O)R b3 , NR c3 C(O)OR a3 , NR c3 C(O)NR c3 R. d3 , C(=NR e3 )R b3 , C(=NOR a3 )R b3 , C(=NR e3 )NR c3 R. d3 , NR c3 C(=NR e3 )NR c3 R. d3 , NR c3 C(=NR e3 )R b3 , NR c3 S(O)R b3 , NR c3 S(O) 2 R. b3 , NR c3 S(O) 2 NR c3 R. d3 , S(O)R b3 , S(O)NR c3 R. d3 , S(O) 2 R. b3 , S(O) 2 NR c3 R. d3 , and BR h3 R. i3 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 30 substituted with 1, 2, 3, or 4 substituents independently selected from; [formation] is a single bond and Y is C, then YR 6 is selected from C=O and C=S; R. 4 is H, D, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 cycloalkyl, 4-6 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, halo, CN, OR a4 , SR a4 , C(O)R b4 , C(O)NR c4 R. d4 , C(O)OR a4 , OC(O)R b4 , OC(O)NR c4 R. d4 , NR c4 R. d4 , NR c4 C(O)R b4 , NR c4 C(O)OR a4 , NR c4 C(O)NR c4 R. d4 , NR c4 S(O)R b4 , NR c4 S(O) 2 R. b4 , NR c4 S(O) 2 NR c4 R. d4 , S(O)R b4 , S(O)NR c4 R. d4 , S(O) 2 R. b4 , S(O) 2 NR c4 R. d4 , and BR h4 R. i4 selected from; R. 5 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , OR a5 , SR a5 , C(O)R b5 , C(O)NR c5 R. d5 , C(O)OR a5 , OC(O)R b5 , OC(O)NR c5 R. d5 , NR c5 R. d5 , NR c5 C(O)R b5 , NR c5 C(O)OR a5 , NR c5 C(O)NR c5 R. d5 , C(=NR e5 )R b5 , C(=NOR a5 )R b5 , C(=NR e5 )NR c5 R. d5 , NR c5 C(=NR e5 )NR c5 R. d5 , NR c5 C(=NR e5 )R b5 , NR c5 S(O)R b5 , NR c5 S(O) 2 R. b5 , NR c5 S(O) 2 NR c5 R. d5 , S(O)R b5 , S(O)NR c5 R. d5 , S(O) 2 R. b5 , S(O) 2 NR c5 R. d5 , and BR h5 R. i5 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 50 substituted with 1, 2, 3, or 4 substituents independently selected from; [formation] is a double bond and Y is N, then R 4 and R 6 does not exist; [formation] is a double bond and Y is C, then R 4 does not exist; R. 6 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , OR a6 , SR a6 , C(O)R b6 , C(O)NR c6 R. d6 , C(O)OR a6 , OC(O)R b6 , OC(O)NR c6 R. d6 , NR c6 R. d6 , NR c6 C(O)R b6 , NR c6 C(O)OR a6 , NR c6 C(O)NR c6 R. d6 , C(=NR e6 )R b6 , C(=NOR a6 )R b6 , C(=NR e6 )NR c6 R. d6 , NR c6 C(=NR e6 )NR c6 R. d6 , NR c6 C(=NR e6 )R b6 , NR c6 S(O)R b6 , NR c6 S(O) 2 R. b6 , NR c6 S(O) 2 NR c6 R. d6 , S(O)R b6 , S(O)NR c6 R. d6 , S(O) 2 R. b6 , S(O) 2 NR c6 R. d6 , and BR h6 R. i6 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 60 substituted with 1, 2, 3, or 4 substituents independently selected from; R. 7 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , OR a7 , SR a7 , C(O)R b7 , C(O)NR c7 R. d7 , C(O)OR a7 , OC(O)R b7 , OC(O)NR c7 R. d7 , NR c7 R. d7 , NR c7 C(O)R b7 , NR c7 C(O)OR a7 , NR c7 C(O)NR c7 R. d7 , C(=NR e7 )R b7 , C(=NOR a7 )R b7 , C(=NR e7 )NR c7 R. d7 , NR c7 C(=NR e7 )NR c7 R. d7 , NR c7 C(=NR e7 )R b7 , NR c7 S(O)R b7 , NR c7 S(O) 2 R. b7 , NR c7 S(O) 2 NR c7 R. d7 , S(O)R b7 , S(O)NR c7 R. d7 , S(O) 2 R. b7 , S(O) 2 NR c7 R. d7 , and BR h7 R. i7 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 70 substituted with 1, 2, 3, or 4 substituents independently selected from; Cy 2 is C 3~10 cycloalkyl, 4-14 membered heterocycloalkyl, C 6~10 aryl, and 5- to 10-membered heteroaryl, wherein 4- to 14-membered heterocycloalkyl and 5- to 10-membered heteroaryl are each independently from at least one ring-forming carbon atom and N, O, and S; having 1, 2, 3, or 4 ring-forming heteroatoms selected as , N and S are optionally oxidized to 5- to 10-membered heteroaryl and 4- to 14-membered heterocycloalkyl The ring-forming carbon atom is optionally substituted with oxo to form a carbonyl group, C 3~10 cycloalkyl, 4-14 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 20 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 10 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , OR a10 , SR a10 , C(O)R b10 , C(O)NR c10 R. d10 , C(O)OR a10 , OC(O)R b10 , OC(O)NR c10 R. d10 , NR c10 R. d10 , NR c10 C(O)R b10 , NR c10 C(O)OR a10 , NR c10 C(O)NR c10 R. d10 , C(=NR e10 )R b10 , C(=NOR a10 )R b10 , C(=NR e10 )NR c10 R. d10 , NR c10 C(=NR e10 )NR c10 R. d10 , NR c10 S(O)Rb10 , NR c10 S(O) 2 R. b10 , NR c10 S(O) 2 NR c10 R. d10 , S(O)R b10 , S(O)NR c10 R. d10 , S(O) 2 R. b10 , S(O) 2 NR c10 R. d10 , and BR h10 R. i10 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 11 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 11 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR a11 , SR a11 , C(O)R b11 , C(O)NR c11 R. d11 , C(O)OR a11 , OC(O)R b11 , OC(O)NR c11 R. d11 , NR c11 R. d11 , NR c11 C(O)R b11 , NR c11 C(O)OR a11 , NR c11 C(O)NR c11 R. d11 , NR c11 S(O)R b11 , NR c11 S(O) 2 R. b11 , NR c11 S(O) 2 NR c11 R. d11 , S(O)R b11 , S(O)NR c11 R. d11 , S(O) 2 R. b11 , S(O) 2 NR c11 R. d11 , and BR h11 R. i11 independently selected from; Each R 20 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , OR a20 , SR a20 , C(O)R b20 , C(O)NR c20 R. d20 , C(O)OR a20 , OC(O)R b20 , OC(O)NR c20 R. d20 , NR c20 R. d20 , NR c20 C(O)R b20 , NR c20 C(O)OR a20 , NR c20 C(O)NR c20 R. d20 , C(=NR e20 )R b20 , C(=NOR a20 )R b20 , C(=NR e20 )NR c20 R. d20 , NR c20 C(=NR e20 )NR c20 R. d20 , NR c20 S(O)R b20 , NR c20 S(O) 2 R. b20 , NR c20 S(O) 2 NR c20 R. d20 , S(O)R b20 , S(O)NR c20 R. d20 , S(O) 2 R. b20 , S(O) 2 NR c20 R. d20 , and BR h20 R. i20 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 21 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 21 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR a21 , SR a21 , C(O)R b21 , C(O)NR c21 R. d21 , C(O)OR a21 , OC(O)R b21 , OC(O)NR c21 R. d21 , NR c21 R. d21 , NR c21 C(O)R b21 , NR c21 C(O)OR a21 , NR c21 C(O)NR c21 R. d21 , NR c21 S(O)R b21 , NR c21 S(O) 2 R. b21 , NR c21 S(O) 2 NR c21 R. d21 , S(O)R b21 , S(O)NR c21 R. d21 , S(O) 2 R. b21 , S(O) 2 NR c21 R. d21 , and BR h21 R. i21 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 22 is C 1~6 Alkyl, C 2~6 alkenyl, C2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , OR a22 , SR a22 , C(O)R b22 , C(O)NR c22 R. d22 , C(O)OR a22 , OC(O)R b22 , OC(O)NR c22 R. d22 , NR c22 R. d22 , NR c22 C(O)R b22 , NR c22 C(O)OR a22 , NR c22 C(O)NR c22 R. d22 , NR c22 S(O)R b22 , NR c22 S(O) 2 R. b22 , NR c22 S(O) 2 NR c22 R. d22 , S(O)R b22 , S(O)NR c22 R. d22 , S(O) 2 R. b22 , S(O) 2 NR c22 R. d22 , and BR h22 R. i22 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 23 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 23 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR a23 , SR a23 , C(O)R b23 , C(O)NR c23 R. d23 , C(O)OR a23 , OC(O)R b23 , OC(O)NR c23 R. d23 , NR c23 R. d23 , NR c23 C(O)R b23 , NR c23 C(O)OR a23 , NR c23 C(O)NR c23 R. d23 , NR c23 S(O)R b23 , NR c23 S(O) 2 R. b23 , NR c23 S(O) 2 NR c23 R. d23 , S(O)R b23 , S(O)NR c23 R. d23 , S(O) 2 R. b23 , S(O) 2 NR c23 R. d23 , and BR h23 R. i23 is independently selected from Each R 30 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , OR a30 , SR a30 , C(O)R b30 , C(O)NR c30 R. d30 , C(O)OR a30 , OC(O)R b30 , OC(O)NR c30 R. d30 , NR c30 R. d30 , NR c30 C(O)R b30 , NR c30 C(O)OR a30 , NR c30 C(O)NR c30 R. d30 , NR c30 S(O)R b30 , NR c30 S(O) 2 R. b30 , NR c30 S(O) 2 NR c30 R. d30 , S(O)R b30 , S(O)NR c30 R. d30 , S(O) 2 R. b30 , S(O) 2 NR c30 R. d30 , and BR h30 R. i30 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 31 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 31 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR a31 , SR a31 , C(O)R b31 , C(O)NR c31 R. d31 , C(O)OR a31 , OC(O)R b31 , OC(O)NR c31 R. d31 , NR c31 R. d31 , NR c31 C(O)R b31 , NR c31 C(O)OR a31 , NR c31 C(O)NR c31 R. d31 , NR c31 S(O)R b31 , NR c31 S(O) 2 R. b31 , NR c31 S(O) 2 NR c31 R. d31 , S(O)R b31 , S(O)NR c31 R. d31 , S(O) 2 R. b31 , S(O) 2 NR c31 R. d31 , and BR h31 R.i31 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 32 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 32 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a32 , SR a32 , C(O)R b32 , C(O)NR c32 R. d32 , C(O)OR a32 , OC(O)R b32 , OC(O)NR c32 R. d32 , NR c32 R. d32 , NR c32 C(O)R b32 , NR c32 C(O)OR a32 , NR c32 C(O)NR c32 R. d32 , NR c32 S(O)R b32 , NR c32 S(O) 2 R. b32 , NR c32 S(O) 2 NR c32 R. d32 , S(O)R b32 , S(O)NR c32 R. d32 , S(O) 2 R. b32 , S(O) 2 NR c32 R. d32 , and BR h32 R. i32 independently selected from; Each R 50 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR a50 , SR a50 , C(O)R b50 , C(O)NR c50 R. d50 , C(O)OR a50 , OC(O)R b50 , OC(O)NR c50 R. d50 , NR c50 R. d50 , NR c50 C(O)R b50 , NR c50 C(O)OR a50 , NR c50 C(O)NR c50 R. d50 , NR c50 S(O)R b50 , NR c50 S(O) 2 R. b50 , NR c50 S(O) 2 NR c50 R. d50 , S(O)R b50 , S(O)NR c50 R. d50 , S(O) 2 R. b50 , S(O) 2 NR c50 R. d50 , and BR h50 R. i50 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 51 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 51 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 Cycloalkyl, C 6~10 aryl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a51 , SR a51 , C(O)R b51 , C(O)NR c51 R. d51 , C(O)OR a51 , OC(O)R b51 , OC(O)NR c51 R. d51 , NR c51 R. d51 , NR c51 C(O)R b51 , NR c51 C(O)OR a51 , NR c51 C(O)NR c51 R. d51 , NR c51 S(O)R b51 , NR c51 S(O) 2 R. b51 , NR c51 S(O) 2 NR c51 R. d51 , S(O)R b51 , S(O)NR c51 R. d51 , S(O) 2 R. b51 , S(O) 2 NR c51 R. d51 , and BR h51 R. i51 independently selected from; Each R 60 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , OR a60 , SR a60 , C(O)R b60 , C(O)NR c60 R. d60 , C(O)OR a60 , OC(O)R b60 , OC(O)NR c60 R. d60 , NR c60 R. d60 , NR c60 C(O)R b60 , NR c60 C(O)OR a60 , NR c60 C(O)NR c60 R. d60 , NR c60 S(O)R b60 , NR c60 S(O) 2 R. b60 , NR c60 S(O) 2 NR c60 R. d60 , S(O)R b60 , S(O)NR c60 R. d60 , S(O) 2 R. b60 , S(O) 2 NR c60 R. d60 , and BR h60 R. i60 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 61 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 61 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR a61 , SR a61 , C(O)R b61 , C(O)NR c61 R. d61 , C(O)OR a61 , OC(O)R b61 , OC(O)NR c61 R. d61 , NR c61 R. d61 , NR c61 C(O)R b61 , NR c61 C(O)OR a61 , NR c61 C(O)NR c61 R. d61 , NR c61 S(O)R b61 , NR c61 S(O) 2 R. b61 , NR c61 S(O) 2 NR c61 R. d61 , S(O)R b61 , S(O)NR c61 R. d61 , S(O) 2 R. b61 , S(O) 2 NR c61 R. d61 , and BR h61 R. i61 independently selected from; Each R 70 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, NO 2 , OR a70 , SR a70 , C(O)R b70 , C(O)NR c70 R. d70 , C(O)OR a70 , OC(O)R b70 , OC(O)NR c70 R. d70 , NR c70 R. d70 , NR c70 C(O)R b70 , NR c70 C(O)OR a70 , NR c70 C(O)NR c70 R. d70 , NR c70 S(O)R b70 , NR c70 S(O) 2 R. b70 , NR c70 S(O) 2 NR c70 R. d70 , S(O)R b70 , S(O)NR c70 R. d70 , S(O) 2 R. b70 , S(O) 2 NR c70 R. d70 , and BR h70 R. i70 independently selected from; R. a1 , R b1 , R c1 , and R d1 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c1 and R d1 together with the N atoms to which they are attached, the R g forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from; R. h1 and R i1 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h1 and R i1 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a2 , R b2 , R c2 , and R d2 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 22 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c2 and R d2 together with the N atoms to which they are attached, the R 22 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; Each R e2 is H, CN, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 1~6 alkylthio, C 1~6 alkylsulfonyl, C 1~6 alkylcarbonyl, C 1~6 alkylaminosulfonyl, carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, aminosulfonyl, C 1~6 alkylaminosulfonyl, and di(C 1~6 independently selected from alkyl)aminosulfonyl; R. h2 and R i2 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h2 and R i2 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a3 , R b3 , R c3 , and R d3 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 30 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c3 and R d3 together with the N atoms to which they are attached, the R 30 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; Each R e3 is H, CN, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 1~6 alkylthio, C 1~6 alkylsulfonyl, C 1~6 alkylcarbonyl, C 1~6 alkylaminosulfonyl, carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, aminosulfonyl, C 1~6 alkylaminosulfonyl, and di(C 1~6 independently selected from alkyl)aminosulfonyl; R. f3 and R j3 are respectively C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 30 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c3 and R j3 together with the N atoms to which they are attached, the R 30 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R. h3 and R i3 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h3 and R i3 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a4 , R b4 , R c4 , and R d4 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c4 and R d4 together with the N atoms to which they are attached, the R g forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from; R. h4 and R i4 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h4 and R i4 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a5 , R b5 , R c5 , and R d5 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 50 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c5 and R d5 together with the N atoms to which they are attached, the R 50 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; Each R e5 is H, CN, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 1~6 alkylthio, C 1~6 alkylsulfonyl, C 1~6 alkylcarbonyl, C 1~6 alkylaminosulfonyl, carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, aminosulfonyl, C 1~6 alkylaminosulfonyl, and di(C 1~6 independently selected from alkyl)aminosulfonyl; R. h5 and R i5 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h5 and R i5 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a6 , R b6 , R c6 , and R d6 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 60 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c6 and R d6 together with the N atoms to which they are attached, the R 60 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; Each R e6 is H, CN, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 1~6 alkylthio, C 1~6 alkylsulfonyl, C 1~6 alkylcarbonyl, C 1~6 alkylaminosulfonyl, carbamyl, C 1~6 Alkylcarbamyl, di(C1~6 Alkyl)carbamyl, aminosulfonyl, C 1~6 alkylaminosulfonyl, and di(C 1~6 independently selected from alkyl)aminosulfonyl; R. h6 and R i6 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h6 and R i6 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a7 , R b7 , R c7 , and R d7 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 70 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c7 and R d7 together with the N atoms to which they are attached, the R 70 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; Each R e7 is H, CN, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 1~6 alkylthio, C 1~6 alkylsulfonyl, C 1~6 alkylcarbonyl, C 1~6 alkylaminosulfonyl, carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, aminosulfonyl, C 1~6 alkylaminosulfonyl, and di(C 1~6 independently selected from alkyl)aminosulfonyl; R. h7 and R i7 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h7 and R i7 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a10 , R b10 , R c10 , and R d10 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 11 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c10 and R d10 together with the N atoms to which they are attached, the R 11 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; Each R e10 is H, CN, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 1~6 alkylthio, C 1~6 alkylsulfonyl, C 1~6 alkylcarbonyl, C 1~6 alkylaminosulfonyl, carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, aminosulfonyl, C 1~6 alkylaminosulfonyl, and di(C 1~6 independently selected from alkyl)aminosulfonyl; R. h10 and R i10 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h10 and R i10 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a11 , R b11 , R c11 , and R d11 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 independently selected from cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl; Alternatively, any R attached to the same N atom c11 and R d11 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R. h11 and R i11 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h11 and R i11 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a20 , R b20 , R c20 , and R d20 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 21 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c20 and R d20 together with the N atoms to which they are attached, the R 21 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; Each R e20 is H, CN, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 1~6 alkylthio, C 1~6 alkylsulfonyl, C 1~6 alkylcarbonyl, C 1~6 alkylaminosulfonyl, carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, aminosulfonyl, C 1~6 alkylaminosulfonyl, and di(C 1~6 independently selected from alkyl)aminosulfonyl; R. h20 and R i20 are respectively OH and C1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h20 and R i20 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a21 , R b21 , R c21 , and R d21 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 is independently selected from cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c21 and R d21 together with the N atoms to which they are attached, the R g forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from; R. h21 and R i21 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h21 and R i21 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a22 , R b22 , R c22 , and R d22 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 23 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c22 and R d22 together with the N atoms to which they are attached, the R 23 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R. h22 and R i22 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h22 and R i22 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a23 , R b23 , R c23 , and R d23 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 independently selected from cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl; Alternatively, any R attached to the same N atom c23 and R d23 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R. h23 and R i23 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h23 and R i23 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a30 , R b30 , R c30 , and R d30 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 31 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c30 and R d30 together with the N atoms to which they are attached, the R 31 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R. h30 and R i30 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h30 and R i30 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a31 , R b31 , R c31 , and R d31 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 is independently selected from cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally R 32 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c31 and R d31 together with the N atoms to which they are attached, the R 32 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from; R. h31 and R i31 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h31 and R i31 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a32 , R b32 , R c32 , and R d32 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6alkynyl, and C 1~6 independently selected from haloalkyl; R. h32 and R i32 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h32 and R i32 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a50 , R b50 , R c50 , and R d50 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 51 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c50 and R d50 together with the N atoms to which they are attached, the R 51 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from; R. h50 and R i50 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h50 and R i50 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a51 , R b51 , R c51 , and R d51 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 independently selected from cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl; Alternatively, any R attached to the same N atom c51 and R d51 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R. h51 and R i51 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h51 and R i51 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a60 , R b60 , R c60 , and R d60 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 61 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c60 and R d60 together with the N atoms to which they are attached, the R 61 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R. h60 and R i60 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h60 and R i60 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a61 , R b61 , R c61 , and R d61 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 independently selected from cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl; Alternatively, any R attached to the same N atom c61 and R d61 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R. h61 and R i61 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h61 and R i61 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R. a70 , R b70 , R c70 , and R d70 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl, and 5- to 10-membered heteroaryl; Alternatively, any R attached to the same N atom c70 and R d70 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R. h70 and R i70 are respectively OH and C 1~6 alkoxy, and C 1~6 any R independently selected from haloalkoxy or attached to the same B atom h70 and R i70 together with the B atoms to which they are attached, the C 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; Each R g is D, OH, NO 2 , CN, halo, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 Cycloalkyl, C 3~6 Cycloalkyl-C 1~2 Alkylene, C 1~6 Alkoxy, C 1~6 haloalkoxy, C 1~3 Alkoxy-C 1~3 Alkyl, C 1~3 Alkoxy-C 1~3 Alkoxy, HO-C 1~3 Alkoxy, HO-C 1~3 Alkyl, cyano-C 1~3 Alkyl, H 2 N-C 1~3 Alkyl, Amino, C 1~6 alkylamino, di(C 1~6 Alkyl)amino, thio, C1~6 alkylthio, C 1~6 Alkylsulfinyl, C 1~6 alkylsulfonyl, carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, carboxy, C 1~6 alkylcarbonyl, C 1~6 Alkoxycarbonyl, C 1~6 Alkylcarbonylamino, C 1~6 Alkoxycarbonylamino, C 1~6 alkylcarbonyloxy, aminocarbonyloxy, C 1~6 alkylaminocarbonyloxy, di(C 1~6 Alkyl)aminocarbonyloxy, C 1~6 alkylsulfonylamino, aminosulfonyl, C 1~6 Alkylaminosulfonyl, di(C 1~6 Alkyl)aminosulfonyl, aminosulfonylamino, C 1~6 Alkylaminosulfonylamino, di(C 1~6 Alkyl)aminosulfonylamino, aminocarbonylamino, C 1~6 alkylaminocarbonylamino, and di(C 1~6 independently selected from alkyl)aminocarbonylamino;

[0013] In another embodiment, the compound of Formula I is a compound of Formula Ia: [formation] or a pharmaceutically acceptable salt thereof, During the ceremony, Y is N or C; R. 1 is H, D, C 1~6 Alkyl, C 1~6 selected from haloalkyl, halo, and CN; R. 2 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR a2 , SR a2 , C(O)R b2 , C(O)NR c2 R. d2 , C(O)OR a2 , OC(O)R b2 , OC(O)NR c2 R. d2 , NR c2 R. d2 , NR c2 C(O)R b2 , NR c2 C(O)OR a2 , NR c2 C(O)NR c2 R. d2 , NR c2 S(O) 2 R. b2 , NR c2 S(O) 2 NR c2 R. d2 , S(O) 2 R. b2 , and S(O) 2 NR c2 R. d2 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 22 substituted with 1, 2, 3, or 4 substituents independently selected from; Cy 1 is C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl, and 6- to 10-membered heteroaryl, wherein the 4- to 10-membered heterocycloalkyl and 6- to 10-membered heteroaryl are each independently from at least one ring-forming carbon atom and N, O, and S; having 1, 2, 3, or 4 ring-forming heteroatoms selected as , N and S are optionally oxidized to form 6- to 10-membered heteroaryl and 4- to 10-membered heterocycloalkyl The ring-forming carbon atom is optionally substituted with oxo to form a carbonyl group, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 6-10 membered heteroaryl are each optionally R 10 substituted with 1, 2, 3, or 4 substituents independently selected from; R. 3 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR f3 , SR a3 , C(O)R b3 , C(O)NR c3 R. d3 , C(O)OR a3 , OC(O)R b3 , OC(O)NR c3 R. d3 , NR c3 R. j3 , NR c3 C(O)R b3 , NR c3 C(O)OR a3 , NR c3 C(O)NR c3 R. d3 , NR c3 S(O) 2 R. b3 , NR c3 S(O) 2 NR c3 R. d3 , S(O) 2 R. b3 , and S(O) 2 NR c3 R. d3 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 30 substituted with 1, 2, 3, or 4 substituents independently selected from; R. 5 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR a5 , SR a5 , C(O)R b5 , C(O)NR c5 R. d5 , C(O)OR a5 , OC(O)R b5 , OC(O)NR c5 R. d5 , NR c5 R. d5 , NR c5 C(O)R b5 , NR c5 C(O)OR a5 , NR c5 C(O)NR c5 R. d5 , NR c5 S(O) 2 R. b5 , NR c5 S(O) 2 NR c5 R. d5 , S(O) 2 R. b5 , and S(O) 2 NR c5R. d5 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 50 substituted with 1, 2, 3, or 4 substituents independently selected from; [formation] is a double bond and Y is N, then R 4 and R 6 does not exist; [formation] is a double bond and Y is C, then R 4 does not exist; R. 6 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR a6 , SR a6 , C(O)R b6 , C(O)NR c6 R. d6 , C(O)OR a6 , OC(O)R b6 , OC(O)NR c6 R. d6 , NR c6 R. d6 , NR c6 C(O)R b6 , NR c6 C(O)OR a6 , NR c6 C(O)NR c6 R. d6 , NR c6 S(O) 2 R. b6 , NR c6 S(O) 2 NR c6 R. d6 , S(O) 2 R. b6 , and S(O) 2 NR c6 R. d6 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 60 substituted with 1, 2, 3, or 4 substituents independently selected from; R. 7 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR a7 , SR a7 , C(O)R b7 , C(O)NR c7 R. d7 , C(O)OR a7 , OC(O)R b7 , OC(O)NR c7 R. d7 , NR c7 R. d7 , NR c7 C(O)R b7 , NR c7 C(O)OR a7 , NR c7 C(O)NR c7 R. d7 , NR c7 S(O) 2 R. b7 , NR c7 S(O) 2 NR c7 R. d7 , S(O) 2 R. b7 , and S(O) 2 NR c7 R. d7 is selected from Cy 2 is C 3~10 cycloalkyl, 4-14 membered heterocycloalkyl, C 6~10 aryl, and 5- to 10-membered heteroaryl, wherein 4- to 14-membered heterocycloalkyl and 5- to 10-membered heteroaryl are each independently from at least one ring-forming carbon atom and N, O, and S; having 1, 2, 3, or 4 ring-forming heteroatoms selected as , N and S are optionally oxidized to 5- to 10-membered heteroaryl and 4- to 14-membered heterocycloalkyl The ring-forming carbon atom is optionally substituted with oxo to form a carbonyl group, C 3~10 cycloalkyl, 4-14 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 20 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 10 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR a10 , SR a10 , C(O)R b10 , C(O)NR c10 R. d10 , C(O)OR a10 , OC(O)R b10 , OC(O)NR c10 R. d10 , NR c10 R. d10 , NR c10 C(O)R b10 , NR c10 C(O)OR a10 , NR c10 C(O)NR c10 R. d10 , NR c10 S(O) 2 R. b10 , NR c10 S(O) 2 NR c10 R. d10 , S(O) 2 R. b10 , and S(O) 2 NR c10 R. d10 independently selected from; Each R 20 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR a20 , SR a20 , C(O)R b20 , C(O)NR c20 R. d20 , C(O)OR a20 , OC(O)R b20 , OC(O)NR c20 R. d20 , NR c20 R. d20 , NR c20 C(O)R b20 , NR c20 C(O)ORa20 , NR c20 C(O)NR c20 R. d20 , NR c20 S(O) 2 R. b20 , NR c20 S(O) 2 NR c20 R. d20 , S(O) 2 R. b20 , and S(O) 2 NR c20 R. d20 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 21 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 21 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR a21 , SR a21 , C(O)R b21 , C(O)NR c21 R. d21 , C(O)OR a21 , OC(O)R b21 , OC(O)NR c21 R. d21 , NR c21 R. d21 , NR c21 C(O)R b21 , NR c21 C(O)OR a21 , NR c21 C(O)NR c21 R. d21 , NR c21 S(O) 2 R. b21 , NR c21 S(O) 2 NR c21 R. d21 , S(O) 2 R. b21 , and S(O) 2 NR c21 R. d21 independently selected from; Each R 22 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR a22 , SR a22 , C(O)R b22 , C(O)NR c22 R. d22 , C(O)OR a22 , OC(O)R b22 , OC(O)NR c22 R. d22 , NR c22 R. d22 , NR c22 C(O)R b22 , NR c22 C(O)OR a22 , NR c22 C(O)NR c22 R. d22 , NR c22 S(O) 2 R. b22 , NR c22 S(O) 2 NR c22 R. d22 , S(O) 2 R. b22 , and S(O) 2 NR c22 R. d22 independently selected from; Each R 30 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR a30 , SR a30 , C(O)R b30 , C(O)NR c30 R. d30 , C(O)OR a30 , OC(O)R b30 , OC(O)NR c30 R. d30 , NR c30 R. d30 , NR c30 C(O)R b30 , NR c30 C(O)OR a30 , NR c30 C(O)NR c30 R. d30 , NR c30 S(O) 2 R. b30 , NR c30 S(O) 2 NR c30 R. d30 , S(O) 2 R. b30 , and S(O) 2 NR c30 R. d30 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 31 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 31 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR a31 , SR a31 , C(O)R b31 , C(O)NR c31 R. d31 , C(O)OR a31 , OC(O)R b31 , OC(O)NR c31 R. d31 , NR c31 R. d31 , NR c31 C(O)R b31 , NR c31 C(O)OR a31 , NR c31 C(O)NR c31 R. d31 , NR c31 S(O) 2 R. b31 , NR c31 S(O) 2 NR c31 R. d31 , S(O) 2 R. b31 , and S(O) 2 NR c31 R. d31 independently selected from; Each R 50 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR a50 , SR a50 , C(O)R b50 , C(O)NR c50 R. d50 , C(O)OR a50 , OC(O)R b50 , OC(O)NR c50 R. d50 , NR c50 R. d50 , NR c50 C(O)R b50 , NR c50 C(O)OR a50 , NR c50 C(O)NR c50 R. d50 , NR c50 S(O) 2 R. b50 , NR c50 S(O) 2 NR c50 R. d50 , S(O) 2 R. b50 , and S(O) 2 NR c50 R. d50 independently selected from; Each R 60 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR a60 , SR a60 , C(O)R b60 , C(O)NR c60 R. d60 , C(O)OR a60 , OC(O)R b60 , OC(O)NR c60 R. d60 , NR c60 R. d60 , NR c60 C(O)R b60 , NR c60 C(O)OR a60 , NR c60 C(O)NR c60 R. d60 , NR c60 S(O) 2 R. b60 , NR c60 S(O) 2 NR c60 R. d60 , S(O) 2 R. b60 , and S(O) 2 NR c60 R. d60 independently selected from; R. a2 , R b2 , R c2 , and R d2 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 22 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c2 and R d2 together with the N atoms to which they are attached, the R 22 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R. a3 , R b3 , R c3 , and R d3 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 30 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c3 and R d3 together with the N atoms to which they are attached, the R 30 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R. f3 and R j3 are respectively C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 30 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c3 and R j3 together with the N atoms to which they are attached, the R 30 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R. a5 , R b5 , R c5 , and R d5 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 50 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c5 and R d5 together with the N atoms to which they are attached, the R 50 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R. a6 , R b6 , R c6 , and R d6 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 60 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c6 and R d6 together with the N atoms to which they are attached, the R 60forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R. a7 , R b7 , R c7 , and R d7 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl, and 5- to 10-membered heteroaryl; Alternatively, any R attached to the same N atom c7 and R d7 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R. a10 , R b10 , R c10 , and R d10 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl, and 5- to 10-membered heteroaryl; Alternatively, any R attached to the same N atom c10 and R d10 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R. a20 , R b20 , R c20 , and R d20 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 21 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c20 and R d20 together with the N atoms to which they are attached, the R 21 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R. a21 , R b21 , R c21 , and R d21 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 independently selected from cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl; Alternatively, any R attached to the same N atom c21 and R d21 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R. a22 , R b22 , R c22 , and R d22 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl, and 5- to 10-membered heteroaryl; Alternatively, any R attached to the same N atom c22 and R d22 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R. a30 , R b30 , R c30 , and R d30 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 31 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c30 and R d30 together with the N atoms to which they are attached, the R 31 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R. a31 , R b31 , R c31 , and R d31 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 independently selected from cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl; Alternatively, any R attached to the same N atom c31 and R d31 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R. a50 , R b50 , R c50 , and R d50 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl, and 5- to 10-membered heteroaryl; Alternatively, any R attached to the same N atom c50 and R d50 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R. a60 , R b60 , R c60 , and R d60 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl, and 5- to 10-membered heteroaryl; Alternatively, any R attached to the same N atom c60 and R d60 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group.

[0014] In one embodiment of Formula Ia or a pharmaceutically acceptable salt thereof, Y is N or C; R. 1 are H, D, and C 1~6 selected from alkyl; R. 2 is H, C 1~6 Alkyl, C 1~6 haloalkyl, halo, D, CN, OR a2 , and NR c2 R. d2 Selected from C above 1~6 Alkyl is optionally R 22 substituted with 1 or 2 substituents independently selected from; Cy 1 is C 6~10 selected from aryl and 6-10 membered heteroaryl, wherein 6-10 membered heteroaryl has at least one ring-forming carbon atom and 1, 2, 3, or independently selected from N, O, and S; The ring-forming carbon atoms of the 6- to 10-membered heteroaryl having 4 ring-forming heteroatoms are optionally substituted with oxo to form a carbonyl group; 6~10 Aryl and 6-10 membered heteroaryl are each optionally R 10 substituted with 1, 2, or 3 substituents independently selected from; R. 3 is H, C 1~6 Alkyl, C 1~6haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl, 5-10 membered heteroaryl, halo, D, CN, OR f3 , and NR c3 R. j3 Selected from C above 1~6 Alkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 30 substituted with 1, 2, or 3 substituents independently selected from; R. 5 is H, C 1~6 Alkyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl, 5-10 membered heteroaryl, halo, D, CN, OR a5 , C(O)NR c5 R. d5 , and NR c5 R. d5 Selected from C above 1~6 Alkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 50 substituted with 1, 2, or 3 substituents independently selected from; [formation] is a double bond and Y is N, then R 4 and R 6 does not exist; [formation] is a double bond and Y is C, then R 4 does not exist; R. 6 is H, C 1~6 Alkyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl, 5-10 membered heteroaryl, halo, D, CN, OR a6 , and NR c6 R. d6 Selected from C above 1~6 Alkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 60 substituted with 1, 2, or 3 substituents independently selected from; R. 7 is H, C 1~6 Alkyl, C 1~6 selected from haloalkyl, halo, D, and CN; Cy 2 is selected from 4- to 10-membered heterocycloalkyl, wherein the 4- to 10-membered heterocycloalkyl is independently selected from at least one ring-forming carbon atom and N, O, and S 1, 2, 3 , or a 4- to 10-membered heterocycloalkyl having 4 ring-forming heteroatoms, wherein the ring-forming carbon atoms of the 4- to 10-membered heterocycloalkyl are optionally substituted with oxo to form a carbonyl group, and a 4- to 10-membered heterocycloalkyl Alkyl is optionally R 20 substituted with 1, 2, or 3 substituents independently selected from; Each R 10 is C 1~6 Alkyl, C 1~6 haloalkyl, halo, D, CN, OR a10 , and NR c10 R. d10 independently selected from; Each R 20 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, halo, D, CN, OR a20 , C(O)R b20 , C(O)NR c20 R. d20 , and NR c20 R. d20 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, and C 2~6 Each alkynyl is optionally R 21 substituted with 1, 2, or 3 substituents independently selected from; Each R 21 is C 1~6 Alkyl, C 1~6 haloalkyl, halo, D, CN, OR a21 , and NR c21 R. d21 independently selected from; Each R 22 is C 1~6 Alkyl, C 1~6 haloalkyl, halo, D, CN, OR a22 , and NR c22 R. d22 independently selected from; Each R 30 is C 1~6 Alkyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl, 5-10 membered heteroaryl, halo, D, CN, OR a30 , C(O)NR c30 R. d30 , and NR c30 R. d30 independently selected from the above C 1~6 Alkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 31 substituted with 1, 2, or 3 substituents independently selected from; Each R 31 is C 1~6 Alkyl, C 1~6 haloalkyl, halo, D, CN, OR a31 , and NR c31 R. d31 independently selected from; Each R 50 is C 1~6 Alkyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl, 5-10 membered heteroaryl, halo, D, CN, OR a50 , and NR c50 R. d50 independently selected from; Each R 60 is C 1~6 Alkyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl, 5-10 membered heteroaryl, halo, D, CN, OR a60 , C(O)NR c60 R. d60 , C(O)OR a60 , and NR c60 R. d60 independently selected from; R. a2 , R c2 , and R d2 are respectively H and C 1~6 alkyl, and C 1~6 independently selected from haloalkyl and C above 1~6 Alkyl is optionally R 22 substituted with 1 or 2 substituents independently selected from; Each R c3 is H, C 1~6 Alkyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 30 substituted with 1, 2, or 3 substituents independently selected from; R. f3 and R j3 are respectively C 1~6 Alkyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 30 substituted with 1, 2, or 3 substituents independently selected from; Alternatively, any R attached to the same N atom c3 and R j3 together with the N atoms to which they are attached, the R 30 forming a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from; R. a5 , R c5 , and R d5 are respectively H and C 1~6 Alkyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 50 substituted with 1, 2, or 3 substituents independently selected from; Alternatively, any R attached to the same N atom c5 and R d5 together with the N atoms to which they are attached, the R 50 forming a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from; R. a6 , R c6 , and R d6 are respectively H and C 1~6 Alkyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 60 substituted with 1, 2, or 3 substituents independently selected from; Alternatively, any R attached to the same N atom c6 and R d6 together with the N atoms to which they are attached, the R 60 forming a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from; R. a10 , R c10 , and R d10 are respectively H and C 1~6 alkyl, and C 1~6 independently selected from haloalkyl; R. a20 , R b20 , R c20 , and R d20 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, and C 1~6 independently selected from haloalkyl and C above 1~6 Alkyl, C 2~6 alkenyl, and C 2~6 Each alkynyl is optionally R 21 substituted with 1, 2, or 3 substituents independently selected from; R. a21 , R c21 , and R d21 are respectively H and C 1~6 alkyl, and C 1~6 independently selected from haloalkyl; R. a22 , R c22 , and R d22 are respectively H and C 1~6 alkyl, and C 1~6 independently selected from haloalkyl; R. a30 , R c30 , and R d30 are respectively H and C 1~6 Alkyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 31 substituted with 1, 2, or 3 substituents independently selected from; Alternatively, any R attached to the same N atom c30 and R d30 together with the N atoms to which they are attached, the R 31 forming a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from; R. a31 , R c31 , and R d31 are respectively H and C 1~6 alkyl, and C 1~6 independently selected from haloalkyl; R. a50 , R c50 , and R d50 are respectively H and C 1~6 Alkyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl, and 5- to 10-membered heteroaryl; Alternatively, any R attached to the same N atom c50 and R d50 together with the N atom to which they are attached form a 4-, 5-, or 6-membered heterocycloalkyl group; R. a60 , R c60 , and R d60 are respectively H and C 1~6 Alkyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl, and 5- to 10-membered heteroaryl; Alternatively, any R attached to the same N atom c60 and R d60 together with the N atom to which they are attached form a 4-, 5-, or 6-membered heterocycloalkyl group.

[0015] In another embodiment of Formula Ia or a pharmaceutically acceptable salt thereof, Y is N or C; R. 1 is H; R. 2 is H, C 1~6 Alkyl, C 1~6 selected from haloalkyl, halo, D, and CN; Cy 1 is C 6~10 selected from aryl and 6- to 10-membered heteroaryl, wherein 6- to 10-membered heteroaryl has at least one ring-forming carbon atom and 1 or 2 ring-forming heteroatoms independently selected from N and O; have, C 6~10 Aryl and 6-10 membered heteroaryl are each optionally R 10 substituted with 1, 2, or 3 substituents independently selected from; R. 3 is H, C 1~6 Alkyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, halo, D, CN, OR f3 , and NR c3 R. j3 Selected from C above 1~6 Alkyl, C 3~10 Cycloalkyl and 4-10 membered heterocycloalkyl are each optionally R 30 substituted with 1, 2, or 3 substituents independently selected from; R. 5 is H, C 1~6 Alkyl, C 1~6 selected from haloalkyl, halo, D, and CN; [formation] is a double bond and Y is N, then R 6 does not exist; R. 6 is H, C 1~6 Alkyl, C 1~6 selected from haloalkyl, halo, D, and CN; R. 7 is H, C 1~6 Alkyl, C 1~6 selected from haloalkyl, halo, D, and CN; Cy 2 is selected from 4- to 6-membered heterocycloalkyl, wherein the 4- to 6-membered heterocycloalkyl has at least one ring-forming carbon atom and 1 or 2 ring-forming heterocycles independently selected from N and O A 4- to 6-membered heterocycloalkyl having atoms is optionally R 20 substituted with 1, 2, or 3 substituents independently selected from; Each R 10 is C 1~6 Alkyl, C 1~6 haloalkyl, halo, D, CN, OR a10 , and NR c10 R. d10 independently selected from; Each R 20 is C 1~6 Alkyl, C 1~6 haloalkyl, halo, D, CN, OR a20 , C(O)R b20 , C(O)NR c20 R. d20 , and NR c20 R. d20 independently selected from the above C 1~6 Alkyl is optionally R 21 substituted with 1 or 2 substituents independently selected from; Each R 21 is C1~6 Alkyl, C 1~6 haloalkyl, halo, D, CN, OR a21 , and NR c21 R. d21 independently selected from; Each R 30 is C 1~6 Alkyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl, 5-10 membered heteroaryl, halo, D, CN, OR a30 , C(O)NR c30 R. d30 , and NR c30 R. d30 independently selected from the above C 1~6 Alkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 31 substituted with 1, 2, or 3 substituents independently selected from; Each R 31 is C 1~6 Alkyl, C 1~6 haloalkyl, halo, D, CN, OR a31 , and NR c31 R. d31 independently selected from; Each R c3 is H, C 1~6 Alkyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 30 substituted with 1, 2, or 3 substituents independently selected from; R. f3 and R j3 are respectively C 1~6 Alkyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 30 substituted with 1, 2, or 3 substituents independently selected from; Alternatively, any R attached to the same N atom c3 and R j3 together with the N atoms to which they are attached, the R 30 forming a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from; R. a10 , R c10 , and R d10 are respectively H and C 1~6 alkyl, and C 1~6 independently selected from haloalkyl; R. a20 , R b20 , R c20 , and R d20 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, and C 1~6 independently selected from haloalkyl and C above 1~6 Alkyl, C 2~6 alkenyl, and C 2~6 Each alkynyl is optionally R 21 substituted with 1, 2, or 3 substituents independently selected from; R. a21 , R c21 , and R d21 are respectively H and C 1~6 alkyl, and C 1~6 independently selected from haloalkyl; R. a30 , R c30 , and R d30 are respectively H and C 1~6 Alkyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 31 substituted with 1, 2, or 3 substituents independently selected from; Alternatively, any R attached to the same N atom c30 and R d30 together with the N atoms to which they are attached, the R 31 forming a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from; R. a31 , R c31 , and R d31 are respectively H and C 1~6 alkyl, and C 1~6 independently selected from haloalkyl;

[0016] In one embodiment, [formation] represents a single or double bond; X is N or CR 7 is; Y is N or C; R. 1 is H, D, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, halo, CN, OR a1 , SR a1 , C(O)R b1 , C(O)NR c1 R. d1 , C(O)OR a1 , OC(O)R b1 , OC(O)NR c1 R. d1 , NR c1 R. d1 , NR c1 C(O)R b1 , NR c1 C(O)OR a1 , NR c1 C(O)NR c1 R. d1 , NR c1 S(O) 2 R. b1 , S(O) 2 R. b1 , and S(O) 2 NR c1 R. d1 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, and C 2~6 Each alkynyl is optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; R. 2 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, halo, D, CN, OR a2 , SR a2 , C(O)R b2 , C(O)NR c2 R. d2 , C(O)OR a2 , OC(O)R b2 , OC(O)NR c2 R. d2 , NR c2 R. d2 , NR c2 C(O)R b2 , NR c2 C(O)OR a2 , NR c2 C(O)NR c2 R. d2 , NR c2 S(O) 2 R. b2 , S(O) 2 R. b2 , and S(O) 2 NR c2 R. d2 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, and C 2~6 Each alkynyl is optionally R 22 substituted with 1, 2, 3, or 4 substituents independently selected from; Cy 1 is C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl, and 6- to 10-membered heteroaryl, wherein the 4- to 10-membered heterocycloalkyl and 6- to 10-membered heteroaryl are each independently from at least one ring-forming carbon atom and N, O, and S; having 1, 2, 3, or 4 ring-forming heteroatoms selected as , N and S are optionally oxidized to form 6- to 10-membered heteroaryl and 4- to 10-membered heterocycloalkyl The ring-forming carbon atom is optionally substituted with oxo to form a carbonyl group, C 3~10cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 6-10 membered heteroaryl are each optionally R 10 substituted with 1, 2, 3, or 4 substituents independently selected from; R. 3 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 alkylene, halo, D, CN, OR f3 , SR a3 , C(O)R b3 , C(O)NR c3 R. d3 , C(O)OR a3 , OC(O)R b3 , OC(O)NR c3 R. d3 , NR c3 R. j3 , NR c3 C(O)R b3 , NR c3 C(O)OR a3 , NR c3 C(O)NR c3 R. d3 , NR c3 S(O) 2 R. b3 , S(O) 2 R. b3 , and S(O) 2 NR c3 R. d3 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 alkylene and 5-10 membered heteroaryl-C 1~3 each alkylene is optionally R 30 substituted with 1, 2, 3, or 4 substituents independently selected from; [formation] is a single bond and Y is C, then YR 6 is selected from C=O and C=S; R. 4 is H, D, C 1~6 alkyl, and C 1~6 is selected from haloalkyl, C above 1~6 Alkyl is optionally R g substituted with 1 or 2 substituents independently selected from; R. 5 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl, 5-10 membered heteroaryl, halo, D, CN, OR a5 , SR a5 , C(O)R b5 , C(O)NR c5 R. d5 , C(O)OR a5 , OC(O)R b5 , OC(O)NR c5 R. d5 , NR c5 R. d5 , NR c5 C(O)R b5 , NR c5 C(O)OR a5 , NR c5 C(O)NR c5 R. d5 , NR c5 S(O) 2 R. b5 , S(O) 2 R. b5 , and S(O) 2 NR c5 R. d5 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 50 substituted with 1, 2, 3, or 4 substituents independently selected from; [formation] is a double bond and Y is N, then R 4 and R 6 does not exist; [formation] is a double bond and Y is C, then R 4 does not exist; R. 6 is H, D, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 cycloalkyl, 4-6 membered heterocycloalkyl, halo, CN, OR a6 , SR a6 , C(O)R b6 , C(O)NR c6 R. d6 , C(O)OR a6 , OC(O)R b6 , OC(O)NR c6 R. d6 , NR c6 R. d6 , NR c6 C(O)R b6 , NR c6 C(O)OR a6 , NR c6 C(O)NR c6 R. d6 , NR c6 S(O) 2 R. b6 , S(O) 2 R. b6 , and S(O) 2 NR c6 R. d6 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each optionally R 60 substituted with 1, 2, 3, or 4 substituents independently selected from; R. 7 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 cycloalkyl and 4- to 6-membered heterocycloalkyl, halo, D, CN, OR a7 , SR a7 , C(O)R b7 , C(O)NR c7 R. d7 , C(O)OR a7 , OC(O)R b7 , OC(O)NR c7 R. d7 , NR c7 R. d7 , NR c7 C(O)R b7 , NR c7 C(O)OR a7 , NR c7 C(O)NR c7 R. d7 , NR c7 S(O) 2 R. b7 , S(O) 2 R. b7 , and S(O) 2 NR c7 R. d7 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each optionally R 70 substituted with 1, 2, 3, or 4 substituents independently selected from; Cy 2 is a 4- to 14-membered heterocycloalkyl, wherein the 4- to 14-membered heterocycloalkyl has at least one ring-forming carbon atom and is independently selected from N, O, and S 1, 2, 3, or 4 ring-forming heteroatoms, N and S are optionally oxidized, and the ring-forming carbon atoms of the 4- to 14-membered heterocycloalkyl are optionally substituted with oxo to form a carbonyl group; The 4- to 14-membered heterocycloalkyl optionally forms R 20 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 10 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6cycloalkyl, 4-6 membered heterocycloalkyl, halo, D, CN, OR a10 , SR a10 , C(O)R b10 , C(O)NR c10 R. d10 , C(O)OR a10 , OC(O)R b10 , OC(O)NR c10 R. d10 , NR c10 R. d10 , NR c10 C(O)R b10 , NR c10 C(O)OR a10 , NR c10 C(O)NR c10 R. d10 , NR c10 S(O) 2 R. b10 , S(O) 2 R. b10 , and S(O) 2 NR c10 R. d10 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each optionally R 11 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 11 is C 1~6 Alkyl, C 1~6 haloalkyl, halo, D, CN, OR a11 , SR a11 , C C(O) R b11 , C(O)NR c11 R. d11 , C(O)OR a11 , OC(O)R b11 , OC(O)NR c11 R. d11 , NR c11 R. d11 , NR c11 C(O)R b11 , NR c11 C(O)OR a11 , NR c11 C(O)NR c11 R. d11 , NR c11 S(O) 2 R. b11 , S(O) 2 R. b11 , and S(O) 2 NR c11 R. d11 independently selected from; Each R 20 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 cycloalkyl, 4-6 membered heterocycloalkyl, halo, D, CN, OR a20 , SR a20 , C(O)R b20 , C(O)NR c20 R. d20 , C(O)OR a20 , OC(O)R b20 , OC(O)NR c20 R. d20 , NR c20 R. d20 , NR c20 C(O)R b20 , NR c20 C(O)OR a20 , NR c20 C(O)NR c20 R. d20 , NR c20 S(O) 2 R. b20 , S(O) 2 R. b20 , and S(O) 2 NR c20 R. d20 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each optionally R 21 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 21 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, halo, D, CN, OR a21 , SR a21 , C(O)R b21 , C(O)NR c21 R. d21 , C(O)OR a21 , OC(O)R b21 , OC(O)NR c21 R. d21 , NR c21 R. d21 , NR c21 C(O)R b21 , NR c21 C(O)OR a21 , NR c21 C(O)NR c21 R. d21 , NR c21 S(O) 2 R. b21 , S(O) 2 R. b21 , and S(O) 2 NR c21 R. d21 independently selected from; Each R 22 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, halo, D, CN, OR a22 , SR a22 , C(O)R b22 , C(O)NR c22 R. d22 , C(O)OR a22 , OC(O)R b22 , OC(O)NR c22 R. d22 , NR c22 R. d22 , NR c22 C(O)R b22 , NR c22 C(O)OR a22 , NR c22 C(O)NR c22 R. d22 , NR c22 S(O) 2 R. b22 , S(O) 2 R. b22 , and S(O) 2 NR c22 R. d22 independently selected from; Each R 30 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl, 5-10 membered heteroaryl, halo, D, CN, OR a30 , SR a30 , C(O)R b30 , C(O)NR c30 R. d30 , C(O)OR a30 , OC(O)R b30 , OC(O)NR c30 R. d30 , NR c30 R. d30 , NR c30 C(O)R b30 , NR c30 C(O)OR a30 , NR c30 C(O)NR c30 R. d30 , NR c30 S(O) 2 R. b30 , S(O) 2 R. b30 , and S(O) 2 NR c30 R. d30 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 31 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 31 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 cycloalkyl, 4-6 membered heterocycloalkyl, halo, D, CN, OR a31 , SR a31 , C(O)R b31 , C(O)NR c31 R. d31 , C(O)OR a31 , OC(O)R b31 , OC(O)NR c31 R. d31 , NR c31 R. d31 , NR c31 C(O)R b31 , NR c31 C(O)OR a31 , NR c31 C(O)NR c31 R. d31 , NR c31 S(O) 2 R. b31 , S(O) 2 R. b31 , and S(O) 2 NR c31 R. d31 independently selected from the above C 1~6Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each optionally R 32 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 32 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, halo, D, CN, OR a32 , SR a32 , C(O)R b32 , C(O)NR c32 R. d32 , C(O)OR a32 , OC(O)R b32 , OC(O)NR c32 R. d32 , NR c32 R. d32 , NR c32 C(O)R b32 , NR c32 C(O)OR a32 , NR c32 C(O)NR c32 R. d32 , NR c32 S(O) 2 R. b32 , S(O) 2 R. b32 , and S(O) 2 NR c32 R. d32 independently selected from; Each R 50 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, halo, D, CN, OR a50 , SR a50 , C(O)R b50 , C(O)NR c50 R. d50 , C(O)OR a50 , OC(O)R b50 , OC(O)NR c50 R. d50 , NR c50 R. d50 , NR c50 C(O)R b50 , NR c50 C(O)OR a50 , NR c50 C(O)NR c50 R. d50 , NR c50 S(O) 2 R. b50 , S(O) 2 R. b50 , and S(O) 2 NR c50 R. d50 independently selected from; Each R 60 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, halo, D, CN, OR a60 , SR a60 , C(O)R b60 , C(O)NR c60 R. d60 , C(O)OR a60 , OC(O)R b60 , OC(O)NR c60 R. d60 , NR c60 R. d60 , NR c60 C(O)R b60 , NR c60 C(O)OR a60 , NR c60 C(O)NR c60 R. d60 , NR c60 S(O) 2 R. b60 , S(O) 2 R. b60 , and S(O) 2 NR c60 R. d60 independently selected from; Each R 70 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, halo, D, CN, OR a70 , SR a70 , C(O)R b70 , C(O)NR c70 R. d70 , C(O)OR a70 , OC(O)R b70 , OC(O)NR c70 R. d70 , NR c70 R. d70 , NR c70 C(O)R b70 , NR c70 C(O)OR a70 , NR c70 C(O)NR c70 R. d70 , NR c70 S(O) 2 R. b70 , S(O) 2 R. b70 , and S(O) 2 NR c70 R. d70 independently selected from; R. a1 , R b1 , R c1 , and R d1 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, and C 1~6 independently selected from haloalkyl and C above 1~6 Alkyl, C 2~6 alkenyl, and C 2~6 Each alkynyl is optionally R g substituted with 1, 2, 3, or 4 substituents independently selected from; R. a2 , R b2 , R c2 , and R d2 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, and C 1~6 independently selected from haloalkyl and C above 1~6 Alkyl, C 2~6 alkenyl, and C 2~6 Each alkynyl is optionally R 22 substituted with 1, 2, 3, or 4 substituents independently selected from; R. a3 , R b3 , R c3 , and R d3 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 30 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c3 and R d3 together with the N atoms to which they are attached, the R 30 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R. f3 and R j3 are respectively C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 30 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c3 and R j3 together with the N atoms to which they are attached, the R 30 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R. a5 , R b5 , R c5 , and R d5 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 50 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c5 and R d5 together with the N atoms to which they are attached, the R 50 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R. a6 , R b6 , R c6 , and R d6 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 is independently selected from cycloalkyl and 4- to 6-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each optionally R 60 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c6 and R d6 together with the N atoms to which they are attached, the R 60 forming a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from; R. a7 , R b7 , R c7 , and R d7 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 is independently selected from cycloalkyl and 4- to 6-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each optionally R 70 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c7 and R d7 together with the N atoms to which they are attached, the R 70 forming a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R. a10 , R b10 , R c10 , and R d10 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 is independently selected from cycloalkyl and 4- to 6-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each optionally R 11 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c10 and R d10 together with the N atoms to which they are attached, the R 11 forming a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R. a11 , R b11 , R c11 , and R d11 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, and C 1~6 independently selected from haloalkyl; R. a20 , R b20 , R c20 , and R d20 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 is independently selected from cycloalkyl and 4- to 6-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each optionally R 21 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c20 and R d20 together with the N atoms to which they are attached, the R 21 forming a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R. a21 , R b21 , R c21 , and R d21 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, and C 1~6 independently selected from haloalkyl; R. a22 , R b22 , R c22 , and R d22 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, and C 1~6 independently selected from haloalkyl; R. a30 , R b30 , R c30 , and R d30 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 31 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c30 and R d30 together with the N atoms to which they are attached, the R 31 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R. a31 , R b31 , R c31 , and R d31 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 is independently selected from cycloalkyl and 4- to 6-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each optionally R 32 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c31 and R d31 together with the N atoms to which they are attached, the R 32 forming a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from; R. a32 , R b32 , R c32 , and R d32 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, and C 1~6 independently selected from haloalkyl; R. a50 , R b50 , R c50 , and R d50 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, and C 1~6 independently selected from haloalkyl; R. a60 , R b60 , Rc60 , and R d60 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, and C 1~6 independently selected from haloalkyl; R. a70 , R b70 , R c70 , and R d70 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, and C 1~6 independently selected from haloalkyl; Each R g is D, OH, CN, halo, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 Cycloalkyl, C 1~6 Alkoxy, C 1~6 haloalkoxy, C 1~3 Alkoxy-C 1~3 Alkyl, C 1~3 HO-C 1~3 Alkyl, cyano-C 1~3 Alkyl, H 2 N-C 1~3 Alkyl, Amino, C 1~6 alkylamino, di(C 1~6 Alkyl)amino, C 1~6 alkylsulfonyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, carboxy, C 1~6 alkylcarbonyl, C 1~6 Alkoxycarbonyl, C 1~6 Alkylcarbonylamino, C 1~6 Alkoxycarbonylamino, C 1~6 alkylcarbonyloxy, C 1~6 alkylaminocarbonyloxy, di(C 1~6 Alkyl)aminocarbonyloxy, C 1~6 alkylaminocarbonylamino, and di(C 1~6 independently selected from alkyl)aminocarbonylamino;

[0017] In one embodiment of Formula I or a pharmaceutically acceptable salt thereof, [formation] represents a single or double bond; X is N or CR 7 is; Y is N or C; R. 1 is H, D, C 1~6 Alkyl, C 1~6 selected from haloalkyl, halo, and CN; R. 2 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, halo, D, CN, OR a2 , and NR c2 R. d2 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, and C 2~6 Each alkynyl is optionally R 22 substituted with 1, 2, 3, or 4 substituents independently selected from; Cy 1 is C 6~10 1, 2, 3, selected from aryl and 6-10 membered heteroaryl, each 6-10 membered heteroaryl independently selected from at least one ring-forming carbon atom and N, O, and S; or 4 ring-forming heteroatoms, wherein the ring-forming carbon atoms of a 6- to 10-membered heteroaryl are optionally substituted with oxo to form a carbonyl group; 6~10 Aryl and 6-10 membered heteroaryl are each optionally R 10 substituted with 1, 2, 3, or 4 substituents independently selected from; R. 3 is H, C 1~6 Alkyl, C 1~6 haloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl, 5-10 membered heteroaryl, halo, D, CN, OR f3 , and NR c3 R. j3 Selected from C above 1~6 alkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 30 substituted with 1, 2, 3, or 4 substituents independently selected from; R. 5 is H, C 1~6 Alkyl, C 1~6 haloalkyl, C 6~10 aryl, 5- to 10-membered heteroaryl, and D, the above C 1~6 Alkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 50 substituted with 1, 2, 3, or 4 substituents independently selected from; [formation] is a double bond and Y is N, then R 4 and R 6 does not exist; [formation] is a double bond and Y is C, then R 4 does not exist; R. 6 is H, D, C 1~6 Alkyl, C 1~6 haloalkyl, C 3~6 is selected from cycloalkyl and 4- to 6-membered heterocycloalkyl; 1~6 Alkyl, C 3~6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each optionally R 60 substituted with 1, 2, 3, or 4 substituents independently selected from; R. 7 is H, C 1~6 Alkyl, C 1~6 selected from haloalkyl, halo, D, and CN; Cy 2 is a 4- to 14-membered heterocycloalkyl, wherein the 4- to 14-membered heterocycloalkyl has at least one ring-forming carbon atom and is independently selected from N, O, and S 1, 2, 3, or 4- to 14-membered heterocycloalkyl having 4 ring-forming heteroatoms is optionally R 20 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 10 is C 1~6 Alkyl, C 1~6 haloalkyl, halo, D, CN, OR a10 , and NR c10 R. d10 independently selected from; Each R 20 is C 1~6 Alkyl, C 1~6 haloalkyl, halo, D, CN, OR a20 , C(O)R b20 , C(O)NR c20 R. d20 , C(O)OR a20 , and NR c20 R. d20 independently selected from the above C 1~6 Alkyl is optionally R 21 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 21 is C 1~6 Alkyl, C 1~6 haloalkyl, halo, D, CN, OR a21 , and NR c21 R. d21 independently selected from; Each R 22 is C 1~6 Alkyl, C 1~6 haloalkyl, halo, D, CN, OR a22 , and NR c22 R. d22 independently selected from; Each R 30 is C 1~6 Alkyl, C 1~6 haloalkyl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, halo, D, CN, OR a30 , and NR c30 R. d30 independently selected from the above C 1~6 Alkyl, 4-10 membered heterocycloalkyl, and 5-10 membered heteroaryl are each optionally R 31 substituted with 1, 2, 3, or 4 substituents independently selected from; Each R 31 is C 1~6 Alkyl, C 1~6 haloalkyl, halo, D, CN, OR a31 , and NR c31 R. d31 independently selected from; Each R 50 is C 1~6 Alkyl, C 1~6 haloalkyl, halo, D, CN, OR a50 , and NR c50 R. d50 independently selected from; Each R 60 is C 1~6 Alkyl, C 1~6haloalkyl, halo, D, CN, OR a60 , C(O)R b60 , C(O)NR c60 R. d60 , C(O)OR a60 , and NR c60 R. d60 independently selected from; R. a2 , R c2 , and R d2 are respectively H and C 1~6 alkyl, and C 1~6 independently selected from haloalkyl; Each R c3 is H, C 1~6 Alkyl, C 1~6 independently selected from haloalkyl, 4-10 membered heterocycloalkyl, and 5-10 membered heteroaryl; 1~6 Alkyl, 4-10 membered heterocycloalkyl, and 5-10 membered heteroaryl are each optionally R 30 substituted with 1, 2, 3, or 4 substituents independently selected from; R. f3 and R j3 are respectively C 1~6 Alkyl, C 1~6 independently selected from haloalkyl, 4-10 membered heterocycloalkyl, and 5-10 membered heteroaryl; 1~6 Alkyl, 4-10 membered heterocycloalkyl, and 5-10 membered heteroaryl are each optionally R 30 substituted with 1, 2, 3, or 4 substituents independently selected from; Alternatively, any R attached to the same N atom c3 and R j3 together with the N atoms to which they are attached, the R 30 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R. a10 , R b10 , R c10 , and R d10 are respectively H and C 1~6 alkyl, and C 1~6 independently selected from haloalkyl; R. a20 , R b20 , R c20 , and R d20 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, and C 1~6 independently selected from haloalkyl and C above 1~6 Alkyl, C 2~6 alkenyl, and C 2~6 Each alkynyl is optionally R 21 substituted with 1, 2, 3, or 4 substituents independently selected from; R. a21 , R b21 , R c21 , and R d21 are respectively H and C 1~6 alkyl, and C 1~6 independently selected from haloalkyl; R. a30 , R b30 , R c30 , and R d30 are respectively H and C 1~6 alkyl, and C 1~6 independently selected from haloalkyl; R. a31 , R b31 , R c31 , and R d31 are respectively H and C 1~6 alkyl, and C 1~6 independently selected from haloalkyl; R. a50 , R b50 , R c50 , and R d50 are respectively H and C 1~6 alkyl, and C 1~6 independently selected from haloalkyl; R. a60 , R b60 , R c60 , and R d60 are respectively H and C 1~6 alkyl, and C 1~6 independently selected from haloalkyl;

[0018] In another embodiment of Formula I or a pharmaceutically acceptable salt thereof, [formation] represents a single or double bond; X is CR 7 is; Y is N or C; R. 1 is H; R. 2 is H, C 1~6 Alkyl, C 1~6 C above is selected from haloalkyl, halo, D, and CN; 1~6 Alkyl is optionally R 22 substituted with 1 or 2 substituents independently selected from; Cy 1 is C 6~10 selected from aryl and 6-10 membered heteroaryl, each 6-10 membered heteroaryl having at least one ring-forming carbon atom and 1 or 2 ring-forming heteroatoms independently selected from N and O and C 6~10 Aryl and 6-10 membered heteroaryl are each optionally R 10 substituted with 1, 2, or 3 substituents independently selected from; R. 3 is H, C 1~6 Alkyl, C 1~6 haloalkyl, 4- to 6-membered heterocycloalkyl, OR f3 , and NR c3 R. j3 Selected from C above 1~6 Alkyl and 4- to 6-membered heterocycloalkyl are each optionally R 30 substituted with 1 or 2 substituents independently selected from; R. 5 is H, C 1~6 Alkyl, C 1~6 is selected from haloalkyl, phenyl, 5-6 membered heteroaryl, and D, C above 1~6 Alkyl, phenyl, and 5-6 membered heteroaryl are each optionally R 50 substituted with 1 or 2 substituents independently selected from; [formation] is a double bond and Y is N, then R 4 and R 6 does not exist; [formation] is a double bond and Y is C, then R 4 does not exist; R. 6 is H, D, C 1~6 alkyl, and C 1~6 is selected from haloalkyl, C above 1~6 Alkyl is optionally R 60 substituted with 1 or 2 substituents independently selected from; R. 7 is selected from halo; Cy 2 is a 4- to 8-membered heterocycloalkyl, wherein the 4- to 8-membered heterocycloalkyl has at least one ring-forming carbon atom and 1 or 2 ring-forming heteroatoms independently selected from N and O and the 4- to 8-membered heterocycloalkyl optionally has R 20 substituted with 1 or 2 substituents independently selected from; Each R 10 is C 1~6 Alkyl, C 1~6 haloalkyl, halo, D, CN, OR a10 , and NR c10 R. d10 independently selected from; Each R 20 is C 1~6 Alkyl, C 1~6 haloalkyl, halo, D, CN, and C(O)R b20 independently selected from the above C 1~6 Alkyl is optionally R 21 substituted with 1 or 2 substituents independently selected from; Each R 21 is C 1~6 Alkyl, C 1~6 haloalkyl, halo, D, CN, OR a21 , and NR c21 R. d21 independently selected from; Each R 22 is C 1~6 Alkyl, C 1~6 haloalkyl, halo, D, CN, OR a22 , and NR c22 R. d22 independently selected from; Each R 30 is C 1~6 Alkyl, C 1~6 haloalkyl, 4-6 membered heterocycloalkyl, 5-6 membered heteroaryl, halo, D, CN, OR a30 , and NR c30 R. d30 independently selected from the above C 1~6 Alkyl, 4-6 membered heterocycloalkyl, and 5-6 membered heteroaryl are each optionally R 31substituted with 1 or 2 substituents independently selected from; Each R 31 is C 1~6 Alkyl, C 1~6 independently selected from haloalkyl, halo, D, and CN; Each R 50 is C 1~6 Alkyl, C 1~6 independently selected from haloalkyl, halo, D, and CN; Each R 60 is C 1~6 Alkyl, C 1~6 haloalkyl, halo, D, CN, OR a60 , C(O)R b60 , C(O)NR c60 R. d60 , C(O)OR a60 , and NR c60 R. d60 independently selected from; Each R c3 is H, C 1~6 alkyl, and C 1~6 independently selected from haloalkyl and C above 1~6 Alkyl is optionally R 30 substituted with 1 or 2 substituents independently selected from; R. f3 and R j3 are respectively C 1~6 Alkyl and C 1~6 independently selected from haloalkyl and C above 1~6 Alkyl is optionally R 30 substituted with 1 or 2 substituents independently selected from; R. a10 , R b10 , R c10 , and R d10 are respectively H and C 1~6 alkyl, and C 1~6 independently selected from haloalkyl; R. a20 , R b20 , R c20 , and R d20 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, and C 1~6 independently selected from haloalkyl and C above 1~6 Alkyl, C 2~6 alkenyl, and C 2~6 Each alkynyl is optionally R 21 substituted with 1 or 2 substituents independently selected from; R. a21 , R b21 , R c21 , and R d21 are respectively H and C 1~6 alkyl, and C 1~6 independently selected from haloalkyl; R. a30 , R b30 , R c30 , and R d30 are respectively H and C 1~6 alkyl, and C 1~6 independently selected from haloalkyl; R. a60 , R b60 , R c60 , and R d60 are respectively H and C 1~6 alkyl, and C 1~6 independently selected from haloalkyl;

[0019] In another embodiment, the compound of Formula I is a compound of Formula II: [formation] or a pharmaceutically acceptable salt thereof.

[0020] In yet another embodiment, R. 1 is H, D, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, halo, CN, OR a1 , and NR c1 R. d1 selected from; R. 2 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, halo, D, CN, OR a2 , and NR c2 R. d2 selected from; Cy 1 is C 6~10 1, 2, 3, selected from aryl and 6-10 membered heteroaryl, each 6-10 membered heteroaryl independently selected from at least one ring-forming carbon atom and N, O, and S; or 4 ring-forming heteroatoms, N and S are optionally oxidized, and the ring-forming carbon atoms of the 6-10 membered heteroaryl are optionally substituted with oxo to form a carbonyl group and C 6~10 Aryl and 6-10 membered heteroaryl are each optionally R 10 substituted with 1 or 2 substituents independently selected from; R. 3 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl, 5-10 membered heteroaryl, halo, D, CN, OR f3 , C(O)R b3 , C(O)NR c3 R. d3 , C(O)OR a3 , OC(O)R b3 , OC(O)NR c3 R. d3 , NR c3 R. j3 , NR c3 C(O)R b3 , NR c3 C(O)OR a3 , and S(O) 2 R. b3 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 30 substituted with 1 or 2 substituents independently selected from; R. 5 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl, 5-10 membered heteroaryl, halo, D, CN, OR a5 , C(O)R b5 , C(O)NR c5 R. d5 , C(O)OR a5 , OC(O)R b5 , OC(O)NR c5 R. d5 , NR c5 R. d5 , NR c5 C(O)R b5 , NR c5 C(O)OR a5 , and S(O) 2 R. b5 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 50 substituted with 1 or 2 substituents independently selected from; R. 7 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, halo, D, CN, OR a7 , and NR c7 R. d7 selected from; Cy 2 is a 4- to 10-membered heterocycloalkyl, wherein the 4- to 10-membered heterocycloalkyl has at least one ring-forming carbon atom and is independently selected from N, O, and S 1, 2, 3, or 4 ring-forming heteroatoms, N and S are optionally oxidized, and the ring-forming carbon atoms of the 4- to 10-membered heterocycloalkyl are optionally substituted with oxo to form a carbonyl group; The 4- to 10-membered heterocycloalkyl optionally forms R 20 substituted with 1 or 2 substituents independently selected from; Each R 10 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, halo, D, CN, OR a10 , C(O)R b10 , C(O)NR c10 R. d10 , C(O)OR a10 , OC(O)R b10 , OC(O)NR c10 R. d10 , NR c10 R. d10 , NR c10 C(O)R b10, NR c10 C(O)OR a10 , and S(O) 2 R. b10 independently selected from; Each R 20 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, halo, D, CN, OR a20 , C(O)R b20 , C(O)NR c20 R. d20 , C(O)OR a20 , OC(O)R b20 , OC(O)NR c20 R. d20 , NR c20 R. d20 , NR c20 C(O)R b20 , NR c20 C(O)OR a20 , and S(O) 2 R. b20 independently selected from; Each R 30 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl, 5-10 membered heteroaryl, halo, D, CN, OR a30 , C(O)R b30 , C(O)NR c30 R. d30 , C(O)OR a30 , OC(O)R b30 , OC(O)NR c30 R. d30 , NR c30 R. d30 , NR c30 C(O)R b30 , NR c30 C(O)OR a30 , and S(O) 2 R. b30 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 31 substituted with 1 or 2 substituents independently selected from; Each R 31 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, halo, D, CN, OR a31 , and NR c31 R. d31 independently selected from; Each R 50 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, halo, D, CN, OR a50 , and NR c50 R. d50 independently selected from; R. a1 , R c1 , and R d1 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, and C 1~6 independently selected from haloalkyl; R. a2 , R c2 , and R d2 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, and C 1~6 independently selected from haloalkyl; R. a3 , R b3 , R c3 , and R d3 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 30 substituted with 1 or 2 substituents independently selected from; Alternatively, any R attached to the same N atom c3 and R d3 together with the N atoms to which they are attached, the R 30 forming a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1 or 2 substituents independently selected from; R. a5 , R b5 , R c5 , and R d5 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 50 substituted with 1 or 2 substituents independently selected from; Alternatively, any R attached to the same N atom c5 and R d5 together with the N atoms to which they are attached, the R 50 forming a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1 or 2 substituents independently selected from; R. a7 , R c7 , and R d7 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, and C 1~6 independently selected from haloalkyl; R. a10 , R b10 , R c10 , and R d10 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, and C 1~6 independently selected from haloalkyl; R. a20 , R b20 , R c20 , and R d20 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, and C 1~6 independently selected from haloalkyl; R. a30 , R b30 , R c30 , and R d30 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 31 substituted with 1 or 2 substituents independently selected from; Alternatively, any R attached to the same N atom c30 and R d30 together with the N atoms to which they are attached, the R 31 forming a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1 or 2 substituents independently selected from; R. a31 , R c31 , and R d31 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, and C 1~6 independently selected from haloalkyl; R. a50 , R c50 , and R d50 are respectively H and C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, and C 1~6 independently selected from haloalkyl;

[0021] In yet another embodiment, R.1 are H, D, and C 1~3 selected from alkyl; R. 2 is H, C 1~3 Alkyl, C 1~3 selected from haloalkyl, halo, D, and CN; Cy 1 is C 6~10 aryl and C 6~10 Aryl is optionally R 10 substituted with 1 or 2 substituents independently selected from; R. 3 is H, C 1~3 is selected from alkyl, 4- to 6-membered heterocycloalkyl, and D; 1~3 Alkyl and 4- to 6-membered heterocycloalkyl are each optionally R 30 substituted with 1 or 2 substituents independently selected from; R. 5 is H, C 1~3 alkyl, and selected from D; R. 7 is H, C 1~3 Alkyl, C 1~3 selected from haloalkyl, halo, D, and CN; Cy 2 is a 4- to 6-membered heterocycloalkyl, wherein the 4- to 6-membered heterocycloalkyl has at least one ring-forming carbon atom and 1 or 2 ring-forming heteroatoms independently selected from N and O and the 4- to 6-membered heterocycloalkyl optionally has R 20 substituted with 1 or 2 substituents independently selected from; Each R 10 is C 1~3 Alkyl, C 1~3 haloalkyl, halo, D, CN, and OR a10 independently selected from; Each R 20 is C 1~3 Alkyl, D, and C(O)R b20 independently selected from; Each R 30 is C 1~3 Alkyl, C 1~3 haloalkyl, halo, D, CN, OR a30 , and NR c30 R. d30 independently selected from; Each R a10 is H and C 1~3 independently selected from alkyl; Each R b20 is H, C 1~3 alkyl, and C 2~3 independently selected from alkenyl; R. a30 , R c30 , and R d30 are respectively H and C 1~3 alkyl, and C 1~3 independently selected from haloalkyl;

[0022] In one embodiment, X is CR 7 is; R. 1 is selected from H; R. 2 is H, C 1~3 selected from haloalkyl, and halo; Cy 1 is C 10 aryl and C 10 Aryl is optionally R 10 substituted with 1 or 2 substituents independently selected from; R. 3 is selected from H and 4-6 membered heterocycloalkyl, wherein said 4-6 membered heterocycloalkyl is optionally R 30 substituted with 1 or 2 substituents independently selected from; R. 5 is H; [formation] is a double bond, Y is N, and R 4 and R 6 does not exist; R. 7 is selected from H or halo; Cy 2 is a 4- to 6-membered heterocycloalkyl, wherein the 4- to 6-membered heterocycloalkyl has at least one ring-forming carbon atom and 1 or 2 ring-forming heteroatoms independently selected from N and O and the 4- to 6-membered heterocycloalkyl optionally has R 20 substituted with 1 or 2 substituents independently selected from; Each R 10 is OR a10 independently selected from; Each R 20 is C(O)R b20 independently selected from; Each R 30 is NR c30 R. d30 independently selected from; Each R a10 is H and C 1~3 independently selected from alkyl; Each R b20 is C 1~3 alkyl or C 2~4 is alkenyl; R. c30 and R d30 are respectively C 1~3 independently selected from alkyl;

[0023] In another embodiment of Formula I or a pharmaceutically acceptable salt thereof, [formation] represents a single or double bond; X is CH or C-halo; Y is N or C; R. 1 is H; R. 2 is H, C 1~6 Alkyl, C 1~6 C above is selected from haloalkyl, halo, and CN; 1~6 Alkyl is optionally D, CN, OH, O(C 1~6 alkyl), NH 2 , NH(C 1~6 alkyl), and N(C 1~6 alkyl) 2 substituted with 1 or 2 substituents independently selected from; Cy 1 is C 6~10 selected from aryl and 6-10 membered heteroaryl, each 6-10 membered heteroaryl having at least one ring-forming carbon atom and 1 or 2 ring-forming heteroatoms independently selected from N and O and C 6~10 Aryl and 6-10 membered heteroaryl are each optionally OH, halo, C 1~6 alkyl, and C 1~6 substituted with 1, 2, or 3 substituents independently selected from haloalkyl; R. 3 is H, C 1~6 alkyl, and 4- to 6-membered heterocycloalkyl, and O(C 1~6 alkyl) and C above 1~6 Alkyl and 4- to 6-membered heterocycloalkyl are each optionally R 30 substituted with 1 or 2 substituents independently selected from; R. 5 is selected from H, phenyl, and 5- to 6-membered heteroaryl, wherein each of said phenyl and 5- to 6-membered heteroaryl is optionally C 1~6 substituted with 1 or 2 substituents independently selected from alkyl; [formation] is a double bond and Y is N, then R 4 and R 6 does not exist; [formation] is a double bond and Y is C, then R 4 does not exist; R. 6 is H, C 1~6 is selected from alkyl and 5- to 10-membered heteroaryl; 1~6 each of the alkyl and 5-10 membered heteroaryl is optionally C 1~6 Alkyl, C(O)N(C 1~6 alkyl) 2 , and C(O)OC 1~6 substituted with 1 or 2 substituents independently selected from alkyl; Cy 2 is a 4- to 8-membered heterocycloalkyl, wherein the 4- to 8-membered heterocycloalkyl has at least one ring-forming carbon atom and 1 or 2 ring-forming heteroatoms independently selected from N and O and the 4- to 8-membered heterocycloalkyl is optionally C 1~6 Alkyl-CN and C(O)R b20 substituted with 1 or 2 substituents independently selected from; Each R 30 is C 1~6 alkyl, 4- to 6-membered heterocycloalkyl, halo, and N(C 1~6 alkyl) 2 and said 4-6 membered heterocycloalkyl is optionally selected from C 1~6 substituted with 1 or 2 substituents independently selected from alkyl; Each R b20 is C 2~6alkenyl and C 2~6 independently selected from alkynyl and C above 2~6 alkenyl and C 2~6 each alkynyl is optionally C 1~6 Alkyl, C 1~6 Alkyl O(C 1~6 alkyl), C 1~6 haloalkyl, halo, and C 1~6 Alkyl-N(C 1~6 alkyl) 2 substituted with 1 or 2 substituents independently selected from

[0024] In another embodiment, the compound of Formula I is a compound of Formula III: [formation] or a pharmaceutically acceptable salt thereof.

[0025] In yet another embodiment, the compound of Formula I is a compound of Formula IV: [formation] or a pharmaceutically acceptable salt thereof.

[0026] In yet another embodiment, the compound of Formula I is a compound of Formula V: [formation] or a pharmaceutically acceptable salt thereof.

[0027] In one embodiment, the compound of Formula I is a compound of Formula VI: [formation] or a pharmaceutically acceptable salt thereof.

[0028] In another embodiment, the compound of Formula I is a compound of Formula VII: [formation] or a pharmaceutically acceptable salt thereof.

[0029] In yet another embodiment, X is CR 7 is. In yet another embodiment, X is N.

[0030] In one embodiment, [formation] is a double bond, Y is N, and R 4 and R 6 does not exist. In another embodiment, [formation] is a single bond and YR 6 is C=O. In one embodiment, [formation] is a double bond, Y is C, and R 4 does not exist.

[0031] In yet another embodiment, R 1 is H, D, C 1~6 Alkyl, C 1~6 haloalkyl, halo, OR a1 , and NR c1 R. d1 is selected from In yet another embodiment, R 1 is H, D, C 1~6 Alkyl, C 1~6 selected from haloalkyl, halo, and CN. In yet another embodiment, R 1 are H, D, and C 1~3 selected from alkyl; In yet another embodiment, R 1 is H.

[0032] In one embodiment, R 2 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, halo, D, CN, OR a2 , and NR c2 R. d2 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, and C 2~6 Each alkynyl is optionally R 22 substituted with 1, 2, 3, or 4 substituents independently selected from In another embodiment, R 2 is H, C 1~6 Alkyl, C 1~6 C above is selected from haloalkyl, halo, D, and CN; 1~6 Alkyl is optionally R 22 substituted with 1 or 2 substituents independently selected from In another embodiment, R 2 is C 1~6 C above is selected from alkyl and halo; 1~6 Alkyl is optionally R 22 substituted with 1 or 2 substituents independently selected from

[0033] In one embodiment, R 2 is H, D, C 1~6 Alkyl, C 1~6 haloalkyl, halo, OR a1 , and NR c1 R. d1 is selected from In another embodiment, R 2 is H, D, C 1~6 selected from alkyl and halo. In yet another embodiment, R 2 is H, D, C 1~6 Alkyl, C 1~6 selected from haloalkyl, halo, and CN. In one embodiment, R 2 is H, D, C 1~2 Alkyl, C 1~2 selected from haloalkyl, halo, and CN. In yet another embodiment, R 2 is a halo. In another embodiment, R 2 is chloro.

[0034] In one embodiment, each R 22 is C 1~6 Alkyl, C 1~6 haloalkyl, halo, D, CN, OR a22 , and NR c22 R. d22 is independently selected from In one embodiment, each R 22 is C 1~6 Alkyl, C 1~6 independently selected from haloalkyl, halo, and CN; In one embodiment, R 22 is CN.

[0035] In yet another embodiment, Cy 1 is C 6~10 1, 2, 3, selected from aryl and 6-10 membered heteroaryl, each 6-10 membered heteroaryl independently selected from at least one ring-forming carbon atom and N, O, and S; or 4 ring-forming heteroatoms, N and S are optionally oxidized, and the ring-forming carbon atoms of the 6-10 membered heteroaryl are optionally substituted with oxo to form a carbonyl group and C 6~10 Aryl and 6-10 membered heteroaryl are each optionally R 10 substituted with 1 or 2 substituents independently selected from

[0036] In one embodiment, Cy 1 is R 10 C optionally substituted with 1 or 2 substituents independently selected from 6~10 is aryl. In another embodiment, Cy 1 is R 10 C optionally substituted with 1 or 2 substituents independently selected from 6~10 is aryl. In yet another embodiment, Cy 1 is optionally R 10 C substituted once with 6~10 is aryl. In yet another embodiment, Cy 1 is optionally R 10 is naphthalenyl substituted once with In yet another embodiment, Cy 1 is 3-hydroxy-naphthalen-1-yl.

[0037] In one embodiment, Cy 1 is C 6~10 selected from aryl and 6-10 membered heteroaryl, each 6-10 membered heteroaryl having at least one ring-forming carbon atom and 1 or 2 ring-forming heteroatoms independently selected from N and O and C 6~10 Aryl and 6-10 membered heteroaryl are each optionally R 10 substituted with 1, 2, or 3 substituents independently selected from . In yet another embodiment, Cy 1 is R 10 is selected from naphthalenyl and 1H-indazolyl optionally substituted with 1 or 2 substituents independently selected from;

[0038] In yet another embodiment, Cy 1 is a 5- to 10-membered heteroaryl with the proviso that Cy 1 is other than 3,5-dimethylisoxazol-4-yl. In another embodiment, Cy1 is other than 3,5-dimethylisoxazol-4-yl.

[0039] In yet another embodiment, each R 10 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, halo, D, CN, OR a10 , and NR c10 R. d10 independently selected from the above C 1~6 Alkyl, C 2~6 alkenyl, and C 2~6 Each alkynyl is optionally R 11 substituted with 1 or 2 substituents independently selected from

[0040] In yet another embodiment, each R 10 is C 1~6 Alkyl, C 1~6 haloalkyl, halo, D, CN, OR a10 , and NR c10 R. d10 is independently selected from In another embodiment, each R 10 is C 1~6 Alkyl, C 1~6 haloalkyl, halo, and OR a10 is independently selected from In one embodiment, each R 10 is C 1~6 alkyl, halo, and OR a10 is independently selected from In another embodiment, each R 10 is independently selected from methyl, chloro, fluoro, trifluoromethyl, and hydroxyl. In another embodiment, each R 10 is independently selected from methyl, fluoro, and hydroxyl.

[0041] In one embodiment, each R 10 is C 1~3 Alkyl, C 1~3 haloalkyl, halo, D, CN, and OR a10 is independently selected from In one embodiment, each R 10 is halo and OR a10 is independently selected from In one embodiment, each R 10 is independently selected from halo and OH. In one embodiment, R 10 is OH.

[0042] In yet another embodiment, each R 11 is C 1~6 Alkyl, C 1~6 haloalkyl, halo, D, CN, OR a11 , and NR c11 R. d11 is independently selected from

[0043] In yet another embodiment, R 3 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl, 5-10 membered heteroaryl, halo, OR f3 , C(O)R b3 , C(O)NR c3 R. d3 , C(O)OR a3 , OC(O)R b3 , OC(O)NR c3 R. d3 , and NR c3 R. j3 Selected from C above 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 30 substituted with 1 or 2 substituents independently selected from

[0044] In one embodiment, R 3 is H, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl, 5- to 10-membered heteroaryl, halo, and OR f3 Selected from C above 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 30 substituted with 1 or 2 substituents independently selected from In one embodiment, R 3 is H, 4-10 membered heterocycloalkyl, C 6~10 Aryl, and OR f3 the above 4-10 membered heterocycloalkyl and C 6~10 each aryl is optionally R 30 substituted with 1 or 2 substituents independently selected from

[0045] In another embodiment, R 3 is H or 4-7 membered heterocycloalkyl, said 4-7 membered heterocycloalkyl is optionally R 30 substituted with 1 or 2 substituents independently selected from In yet another embodiment, R 3 is 4-7 membered heterocycloalkyl, said 4-7 membered heterocycloalkyl is optionally R 30 substituted with 1 or 2 substituents independently selected from In yet another embodiment, R 3 is a 4-membered heterocycloalkyl and R 30 optionally substituted with 1 or 2 substituents independently selected from .

[0046] In another embodiment, R 3 is H, 4- to 6-membered heterocycloalkyl, and OR f3 wherein said 4-6 membered heterocycloalkyl is optionally selected from R 30 substituted with 1 or 2 substituents independently selected from In one embodiment, R 3 is a 4-membered heterocycloalkyl and optionally R 30 is replaced once with . In another embodiment, R 3 is selected from H and 3-(dimethylamino)azetidin-1-yl. In another embodiment, R 3 is selected from H, 3-(dimethylamino)azetidin-1-yl, and -(S)-1-methylpyrrolidin-2-yl)methoxy. In another embodiment, R 3 is 3-(dimethylamino)azetidin-1-yl. In yet another embodiment, R 3 is H.

[0047] In one embodiment, each R 30 is C 1~6 Alkyl, C 1~6 haloalkyl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, halo, D, CN, OR a30 , and NR c30 R. d30 independently selected from the above C 1~6 Alkyl, 4-10 membered heterocycloalkyl, and 5-10 membered heteroaryl are each optionally R 31 substituted with 1, 2, 3, or 4 substituents independently selected from In one embodiment, each R 30 is C 1~6 Alkyl, C 1~6 haloalkyl, 4-6 membered heterocycloalkyl, 5-6 membered heteroaryl, halo, D, CN, OR a30 , and NR c30 R. d30 independently selected from the above C 1~6 Alkyl, 4-6 membered heterocycloalkyl, and 5-6 membered heteroaryl are each optionally R 31 substituted with 1 or 2 substituents independently selected from

[0048] In another embodiment, R 30 is NR c30 R. d30 is. In yet another embodiment, R 30 is NR c30 R. d30 and R c30 and R d30 are independently C 1~3 is alkyl.

[0049] In another embodiment, each R 30 is 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, halo, OR a30 , and NR c30 R. d30 wherein each of said 4-10 membered heterocycloalkyl and 5-10 membered heteroaryl is independently selected from R 31 substituted with 1 or 2 substituents independently selected from

[0050] In yet another embodiment, each R 31 is C 1~6 alkyl, halo, D, CN, OR a31 , and NR c31 R. d31 is independently selected from In one embodiment, each R 31 is C 1~6 Alkyl, C 1~6 independently selected from haloalkyl, halo, D, and CN; In one embodiment, each R 31 is independently C 1~6is alkyl. In another embodiment, each R 31 is independently methyl.

[0051] In another embodiment, R a3 , R b3 , R c3 , and R d3 are respectively H and C 1~6 alkyl, and C 1~6 independently selected from haloalkyl and C above 1~6 Alkyl is optionally R 30 substituted with 1 or 2 substituents independently selected from In another embodiment, R f3 and R j3 are respectively C 1~6 Alkyl and C 1~6 independently selected from haloalkyl and C above 1~6 Alkyl is optionally R 30 substituted with 1 or 2 substituents independently selected from

[0052] In yet another embodiment, each R a3 is independently C 1~6 Alkyl, above C 1~6 Alkyl is optionally R 30 substituted with one substituent independently selected from In yet another embodiment, each R a3 is independently methyl, said methyl being R 30 substituted with one substituent independently selected from

[0053] In another embodiment, each R f3 is independently C 1~6 Alkyl, above C 1~6 Alkyl is optionally R 30 substituted with one substituent independently selected from In yet another embodiment, each R f3 is independently methyl, said methyl being R 30 substituted with one substituent independently selected from

[0054] In one embodiment, R 4 is H, D, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 cycloalkyl, 4-6 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, halo, CN, OR a4 , C(O)R b4 , C(O)NR c4 R. d4 , C(O)OR a4 , OC(O)R b4 , OC(O)NR c4 R. d4 , NR c4 R. d4 , NR c4 C(O)R b4 , NR c4 C(O)OR a4 , NR c4 C(O)NR c4 R. d4 , NR c4 S(O) 2 R. b4 , S(O) 2 R. b4 , and S(O) 2 NR c4 R. d4 is selected from In another embodiment, R 4 is H, D, C 1~6 Alkyl, C 1~6 haloalkyl, C 3~6 cycloalkyl, 4-6 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, halo, CN, OR a4 , C(O)R b4 , C(O)NR c4 R. d4 , C(O)OR a4 , and OC(O)R b4 is selected from In yet another embodiment, R 4 is H, D, C 1~6 Alkyl, C 1~6 selected from haloalkyl, halo, and CN. In yet another embodiment, R 4 is H.

[0055] In one embodiment, R 5 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 alkylene, halo, D, CN, OR a5 , SR a5 , C(O)R b5 , C(O)NR c5 R. d5 , C(O)OR a5 , OC(O)R b5 , NR c5 R. d5 , and NR c5 C(O)R b5 is selected from In another embodiment, R 5 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 selected from aryl, 5-10 membered heteroaryl, D, CN, and halo. In yet another embodiment, R 5 is H, C 1~6 Alkyl, C 1~6 selected from haloalkyl, D, CN, and halo. In yet another embodiment, R 5 is H or C 1~3 is alkyl. In another embodiment, R 5 is H.

[0056] In one embodiment, R 5 is H, C 1~6 Alkyl, C 1~6 haloalkyl, C 6~10 aryl, 5- to 10-membered heteroaryl, and D, the above C 1~6 Alkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 50 substituted with 1, 2, 3, or 4 substituents independently selected from In another embodiment, R 5 is H, C 1~6 Alkyl, C 1~6 is selected from haloalkyl, phenyl, 5-6 membered heteroaryl, and D, C above 1~6 Alkyl, phenyl, and 5-6 membered heteroaryl are each optionally R 50 substituted with 1 or 2 substituents independently selected from

[0057] In one embodiment, R 5 is H, C 1~6 Alkyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl, 5-10 membered heteroaryl, halo, D, CN, OR a5 , C(O)NR c5 R. d5 , and NR c5 R. d5 Selected from C above 1~6 Alkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 50 substituted with 1, 2, or 3 substituents independently selected from . In another embodiment, R 5 is H, C 1~6 Alkyl, C 1~6 haloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl, 5-10 membered heteroaryl, halo, CN, OR a5 , and C(O)NR c5 R. d5 Selected from C above 1~6 alkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 50 substituted with 1, 2, or 3 substituents independently selected from .

[0058] In another embodiment, each R 50 is C 1~6 Alkyl, C 1~6 haloalkyl, halo, D, CN, OR a50 , and NR c50 R. d50 is independently selected from In one embodiment, each R 50 is C 1~6 Alkyl, C 1~6 independently selected from haloalkyl, halo, D, and CN; In one embodiment, each R 50 is C 1~6 is alkyl.

[0059] In one embodiment, each R 50 is C 1~6 Alkyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl, 5-10 membered heteroaryl, halo, D, CN, OR a50 , and NR c50 R. d50is independently selected from In another embodiment, each R 50 is C 1~6 Alkyl, C 1~6 haloalkyl, C 6~10 aryl, 5-10 membered heteroaryl, halo, CN, OR a50 , and NR c50 R. d50 is independently selected from

[0060] In one embodiment, each R 51 is C 1~6 Alkyl, C 1~6 haloalkyl, halo, D, CN, OR a51 , and NR c51 R. d51 is independently selected from In another embodiment, each R 51 is C 1~6 Alkyl, C 1~6 independently selected from haloalkyl, halo, D, and CN;

[0061] In one embodiment, R 6 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl, 5-10 membered heteroaryl, halo, D, CN, NO 2 , OR a6 , SR a6 , C(O)R b6 , C(O)NR c6 R. d6 , C(O)OR a6 , OC(O)R b6 , OC(O)NR c6 R. d6 , NR c6 R. d6 , NR c6 C(O)R b6 , NR c6 C(O)OR a6 , NR c6 C(O)NR c6 R. d6 , NR c6 S(O)R b6 , NR c6 S(O) 2 R. b6 , NR c6 S(O) 2 NR c6 R. d6 , S(O)R b6 , S(O)NR c6 R. d6 , S(O) 2 R. b6 , and S(O) 2 NR c6 R. d6 is selected from In another embodiment, R 6 is H, D, C 1~6 Alkyl, C 1~6 haloalkyl, OR a6 , and NR c6 R. d6 is selected from In another embodiment, R 6 is H, D, C 1~6 alkyl, and C 1~6 selected from haloalkyl;

[0062] In one embodiment, R 6 is H, D, C 1~6 Alkyl, C 1~6 haloalkyl, C 3~6 is selected from cycloalkyl and 4- to 6-membered heterocycloalkyl; 1~6 Alkyl, C 3~6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each optionally R 60 substituted with 1, 2, 3, or 4 substituents independently selected from In another embodiment, R 6 is H, D, C 1~6 alkyl, and C 1~6 is selected from haloalkyl, C above 1~6 Alkyl is optionally R 60 substituted with 1 or 2 substituents independently selected from

[0063] In yet another embodiment, R 6 is H, C 1~6 Alkyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl, 5-10 membered heteroaryl, halo, D, CN, OR a6 , and NR c6 R. d6 Selected from C above 1~6 Alkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 60 substituted with 1, 2, or 3 substituents independently selected from .

[0064] In one embodiment, each R 60 is C 1~6 Alkyl, C 1~6 haloalkyl, halo, D, CN, OR a60 , C(O)R b60 , C(O)NR c60 R. d60 , C(O)OR a60 , and NR c60 R. d60 is independently selected from In another embodiment, each R 60 is C 1~6 Alkyl, C 1~6 Haloalkyl, CN, C(O)NR c60 R. d60 , and C(O)OR a60 is independently selected from

[0065] In one embodiment, each R 60 is C 1~6 Alkyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl, 5-10 membered heteroaryl, halo, D, CN, OR a60 , C(O)NR c60 R. d60 , C(O)OR a60 , and NR c60 R. d60 is independently selected from In another embodiment, each R 60 is C 1~6 Alkyl, C 1~6 haloalkyl, C 6~10 aryl, halo, D, CN, OR a60 , C(O)NR c60 R. d60 , C(O)OR a60 , and NR c60 R. d60 is independently selected from

[0066] In yet another embodiment, R 7 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl, 5-10 membered heteroaryl, halo, D, CN, NO 2 , OR a7 , SR a7 , C(O)R b7 , C(O)NR c7 R. d7 , C(O)OR a7 , OC(O)R b7 , OC(O)NR c7 R. d7 , NR c7 R. d7 , NR c7 C(O)R b7 , NR c7 C(O)OR a7 , NR c7 C(O)NR c7 R. d7 , NR c7 S(O) 2 R. b7 , NR c7 S(O) 2 NR c7 R. d7 , S(O) 2 R. b7 , and S(O) 2 NR c7 R. d7 is selected from In yet another embodiment, R 7 is H, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 selected from aryl, 5-10 membered heteroaryl and halo. In one embodiment, R 7 is H, D, C 1~3 Alkyl, C 1~3 selected from haloalkyl, CN, and halo. In yet another embodiment, R 7 is a halo. In yet another embodiment, R 7 is fluoro.

[0067] In one embodiment, Cy 2 is a 4- to 6-membered heterocycloalkyl, wherein the 4- to 6-membered heterocycloalkyl has at least one ring-forming carbon atom and 1 or 2 ring-forming heteroatoms independently selected from N and O and the 4- to 6-membered heterocycloalkyl optionally has R 20 substituted with 1 or 2 substituents independently selected from

[0068] In another embodiment, Cy 2 is C 3~6 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl, and 5- to 10-membered heteroaryl, wherein the 4- to 10-membered heterocycloalkyl and 5- to 10-membered heteroaryl are each independently from at least one ring-forming carbon atom and N, O, and S; having 1, 2, 3, or 4 ring-forming heteroatoms selected as , N and S are optionally oxidized to form 5- to 10-membered heteroaryl and 4- to 10-membered heterocycloalkyl The ring-forming carbon atom is optionally substituted with oxo to form a carbonyl group, C 3~6 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each optionally R 20 substituted with 1 or 2 substituents independently selected from

[0069] In another embodiment, Cy 2 is a 4- to 10-membered heterocycloalkyl, wherein the 4- to 10-membered heterocycloalkyl has at least one ring-forming carbon atom and 1 or 2 ring-forming heteroatoms independently selected from N and O and the 4- to 10-membered heterocycloalkyl optionally has R 20 substituted with 1 or 2 substituents independently selected from

[0070] In yet another embodiment, Cy 2 is a 4- to 6-membered heterocycloalkyl, wherein the 4- to 6-membered heterocycloalkyl has at least one ring-forming carbon atom and 1 or 2 ring-forming heteroatoms independently selected from N and O and the 4- to 6-membered heterocycloalkyl is optionally R 20 is replaced once with .

[0071] In yet another embodiment, Cy 2 is 4-(piperidin-1-yl)prop-2-en-1-one, 3-(piperidin-1-yl)prop-2-en-1-one, 3-azetidin-1-yl)prop- 2-en-1-one, and 3-pyrrolidin-1-yl)prop-2-en-1-one. In yet another embodiment, Cy 2 is 4-(piperidin-1-yl)prop-2-en-1-one. In one embodiment, Cy 2 is 3-(piperidin-1-yl)prop-2-en-1-one. In another embodiment, Cy 2 is 3-(azetidin-1-yl)prop-2-en-1-one. In yet another embodiment, Cy 2 is 3-(pyrrolidin-1-yl)prop-2-en-1-one.

[0072] In one embodiment, Cy 2 is 1 or 2 R 20 is a 4- to 6-membered heterocycloalkyl optionally substituted with . In yet another embodiment, R 20 is C(O)R b20 is.

[0073] In one embodiment, Cy 2 teeth,

table 1

[0074] In another embodiment, Cy 2 is Cy 2 -a. In yet another embodiment, Cy 2 is Cy 2 -b. In yet another embodiment, Cy 2 is Cy 2 is -c. In one embodiment, Cy 2 is Cy 2 -d.

[0075] In yet another embodiment, Cy 2 teeth, [Table 2] is selected from where n is 0, 1, or 2.

[0076] In one embodiment, Cy 2 is Cy 2 -a1. In another embodiment, Cy 2 is Cy 2 -b1. In yet another embodiment, Cy 2 is Cy 2 -c1. In yet another embodiment, Cy 2 is Cy 2 -d1. In one embodiment, Cy 2 is Cy 2 -e.

[0077] In one embodiment, n is 0. In another embodiment, n is 1. In yet another embodiment, n is two.

[0078] In one embodiment, each R 20 is C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl, 5-10 membered heteroaryl, halo, D, CN, OR a20 , C(O)R b20 , C(O)NR c20 R. d20 , C(O)OR a20 , OC(O)R b20 , OC(O)NR c20 R. d20 , NR c20 R. d20 , NR c20 C(O)R b20 , NR c20 C(O)OR a20 , NR c20 C(O)NR c20 R. d20 , NR c20 S(O) 2 R. b20 , NR c20 S(O) 2 NR c20 R. d20 , S(O) 2 R. b20 , and S(O) 2 NR c20 R. d20 is independently selected from

[0079] In yet another embodiment, each R 20 is C(O)R b20 , C(O)NR c20 R. d20 , and C(O)OR a20 is independently selected from In yet another embodiment, each R 20 is C(O)R b20 is.

[0080] In one embodiment, each R 20 is C 1~6 Alkyl, C 1~6 haloalkyl, halo, D, CN, OR a20 , C(O)R b20 , C(O)NR c20 R. d20 , C(O)OR a20 , and NR c20 R. d20 independently selected from the above C 1~6 Alkyl is optionally R 21 substituted with 1, 2, 3, or 4 substituents independently selected from

[0081] In one embodiment, each R 20 is C 1~6 Alkyl, C 1~6 haloalkyl, halo, D, CN, and C(O)R b20 independently selected from the above C 1~6 Alkyl is optionally R 21 substituted with 1 or 2 substituents independently selected from In one embodiment, each R 20 is C 1~6 Alkyl, CN, and C(O)R b20 independently selected from the above C 1~6 Alkyl is optionally R 21 substituted with 1 or 2 substituents independently selected from

[0082] In another embodiment, each R 21 is C 1~6 Alkyl, C 1~6 haloalkyl, halo, D, CN, OR a21 , and NR c21 R. d21 is independently selected from In another embodiment, each R 21 is C 1~6 Alkyl, C 1~6 haloalkyl, halo, D, CN, and OR a21 is independently selected from In another embodiment, R 21 is CN.

[0083] In another embodiment, each R g is D, OH, CN, halo, C 1~6 Alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 haloalkyl, C 3~6 Cycloalkyl, C 1~6 Alkoxy, C 1~6 haloalkoxy, C1~3 Alkoxy-C 1~3 Alkyl, C 1~3 Alkoxy-C 1~3 Alkoxy, HO-C 1~3 Alkoxy, HO-C 1~3 Alkyl, cyano-C 1~3 Alkyl, H 2 N-C 1~3 Alkyl, Amino, C 1~6 alkylamino, di(C 1~6 Alkyl)amino, C 1~6 alkylthio, C 1~6 alkylsulfonyl, carbamyl, C 1~6 alkylcarbamyl, and di(C 1~6 independently selected from alkyl)carbamyl;

[0084] In one embodiment of Formula Ia or a pharmaceutically acceptable salt thereof, Y is N or C; R. 1 is H; R. 2 is H, C 1~6 Alkyl, C 1~6 selected from haloalkyl and halo, alkyl optionally substituted once with CN; Cy 1 is C 6~10 selected from aryl and 6- to 10-membered heteroaryl, wherein 6- to 10-membered heteroaryl has at least one ring-forming carbon atom and 1 or 2 ring-forming heteroatoms independently selected from N and O; have, C 6~10 Aryl and 6-10 membered heteroaryl are each optionally OH, halo, C 1~6 Alkyl, C 1~6 substituted with 1, 2, or 3 substituents independently selected from haloalkyl, and CN; R. 3 is H, C 3~10 cycloalkyl, 4-10 membered heterocycloalkyl, halo, and OC 1~6 selected from alkyl and OC above 1~6 Alkyl, C 3~10 Cycloalkyl and 4-10 membered heterocycloalkyl are each optionally N(C 1~6 alkyl) 2 , C 1~6 alkyl, and optionally C 1~6 substituted with 1, 2, or 3 substituents independently selected from 4- to 6-membered heterocycloalkyl substituted with alkyl; R. 5 is H, C 1~6 Alkyl, C 6~10 Aryl, 5-6 membered heteroaryl, C 1~6 haloalkyl, halo, C(O)NH(C 1~6 alkyl), and 4- to 6-membered heterocycloalkyl, wherein heteroaryl, heterocycloalkyl, and alkyl are optionally C 1~6 Alkyl, OH, C 6~10 aryl, and N(C 1~6 alkyl) 2 substituted with 1 or 2 substituents selected from; If Y is N then R 6 does not exist; R. 6 is H, C 1~6 alkyl, 5-6 membered heteroaryl, and C 1~6 selected from haloalkyl, wherein alkyl and heteroaryl are optionally selected from C 1~6 Alkyl, C(O)OC 1~6 Alkyl, C(O)N(C 1~6 alkyl) 2 , C 6~10 substituted with 1 or 2 substituents selected from aryl and C(O)(4- to 6-membered heterocycloalkyl); R. 7 is selected from H and halo; Cy 2 is selected from 4- to 6-membered heterocycloalkyl, wherein the 4- to 6-membered heterocycloalkyl has at least one ring-forming carbon atom and 1 or 2 ring-forming heterocycles independently selected from N and O A 4- to 6-membered heterocycloalkyl having atoms is optionally C(O)C 2~6 alkenyl, C(O)C 2~6 alkynyl, C 1~6 substituted with 1, 2, or 3 substituents independently selected from alkyl, wherein alkenyl and alkyl are optionally CN, N(C 1~6 alkyl) 2 , OC 1~6 substituted once or twice with a substituent selected from alkyl and halo.

[0085] In one embodiment, the compound of formula I is 1-(4-(8-chloro-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-1H-pyrazolo[4,3-c]-quinolin-1-yl)-piperidin-1-yl ) prop-2-en-1-one or 1-(4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-1H-pyrazolo[4,3 -c]quinolin-1-yl)piperidin-1-yl)prop-2-en-1-one, or a pharmaceutically acceptable salt thereof.

[0086] In another embodiment, the compound of formula I is 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidine -1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl )-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl )-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl )-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl )-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4,4-difluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl )-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl )-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4,4-difluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl )-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3 -(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazeti Din-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidine-2 -yl) acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3 -(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazeti Din-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile ; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazeti Din-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl) acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazeti Din-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4,4-difluorobut-2-enoyl)piperidine-2- yl) acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazeti din-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)- 3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1- Methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidine-2- yl) acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro- 4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1- methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(((S )-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(5-fluoroquinoline-8- yl)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(isoquinolin-4-yl)- 1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(2-chloro-3-methylphenyl)-4-(3-(dimethylamino)azetidin-1-yl)-6 -fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(2-chloro-3-methylphenyl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H -pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(2,3-dichlorophenyl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro- 1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(2,3-dichlorophenyl)-4-(3-(dimethylamino)azetidin-1-yl )-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-methyl-2-( trifluoromethyl)phenyl)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-6-fluoro-7-(3-methyl-2-(trifluoromethyl)phenyl)-4-(((S)-1 -methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-8-(2-cyanoethyl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(( (S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-2-yl)methyl propanoate; 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-8-(2-cyanoethyl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(( (S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-2-yl)-N,N-dimethylpropanamide; 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidine) -2-yl)methoxy)-2-propyl-1H-pyrrolo[3,2-c]quinolin-8-yl)propanenitrile; 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-2-(1-methyl-1H-pyrazole-4 -yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propanenitrile; 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidine) -2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propanenitrile; 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidine) -2-yl)methoxy)-3-phenyl-1H-pyrrolo[3,2-c]quinolin-8-yl)propanenitrile; 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidine) -2-yl)methoxy)-3-(pyridin-3-yl)-1H-pyrrolo[3,2-c]quinolin-8-yl)propanenitrile; 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-3-(2-methyloxazol-5-yl) -4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propanenitrile; 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidine) -2-yl)methoxy)-3-(2-methylthiazol-5-yl)-1H-pyrrolo[3,2-c]quinolin-8-yl)propanenitrile; and 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-3-(1-methyl-1H-pyrazole-4 -yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propanenitrile; or a pharmaceutically acceptable salt thereof.

[0087] In yet another embodiment, the compound of formula I is 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-2-(1-methyl-1H-pyrazole-3 -yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propanenitrile; 3-(2-benzyl-1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)- 1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propanenitrile; 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidine) -2-yl)methoxy)-3-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]quinolin-8-yl)propanenitrile; 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidine) -2-yl)methoxy)-3-(6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrrolo[3,2-c]quinolin-8-yl)propanenitrile; 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-3-chloro-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)- 1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propanenitrile; 1-(2-Azabicyclo[2.1.1]hexan-5-yl)-8-(2-cyanoethyl)-6-fluoro-N-(2-hydroxyethyl)-7-(3-hydroxynaphthalen-1-yl )-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinoline-3-carboxamide; N-benzyl-1-(2-azabicyclo[2.1.1]hexan-5-yl)-8-(2-cyanoethyl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-( ((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinoline-3-carboxamide; 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-3-(hydroxymethyl)-7-(3-hydroxynaphthalen-1-yl)-4-((( S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propanenitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidine) -2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 3-(1-((1R,4R,5S)-2-azabicyclo[2.1.1]hexan-5-yl)-8-(2-cyanoethyl)-4-ethoxy-6-fluoro-7-(3- Hydroxynaphthalen-1-yl)-1H-pyrrolo[3,2-c]quinolin-2-yl)-N,N-dimethylpropanamide; 3-(1-((1R,4R,5S)-2-azabicyclo[2.1.1]hexan-5-yl)-8-(2-cyanoethyl)-3-(3-(dimethylamino)azetidine-1- yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-methoxy-1H-pyrrolo[3,2-c]quinolin-2-yl)methyl propanoate; 3-(2-(3-(azetidin-1-yl)-3-oxopropyl)-1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(7-fluoro naphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propanenitrile; 8-(1-((2S,4S)-2-(cyanomethyl)-1-((E)-4-fluorobut-2-enoyl)piperidin-4-yl)-6-fluoro-8-methyl-4 -(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthonitrile; 8-(1-((2S,4S)-2-(cyanomethyl)-1-(2-fluoroacryloyl)piperidin-4-yl)-6-fluoro-8-methyl-4-(((S)-1 -methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthonitrile; 8-(1-((2S,4S)-1-(but-2-ynoyl)-2-(cyanomethyl)piperidin-4-yl)-6-fluoro-8-methyl-4-(((S)- 1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthonitrile; 8-(1-((2S,4S)-2-(cyanomethyl)-1-((E)-4-methoxybut-2-enoyl)piperidin-4-yl)-6-fluoro-8-methyl-4- (((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthonitrile; 8-(1-((2S,4S)-2-(cyanomethyl)-1-((E)-4-fluorobut-2-enoyl)piperidin-4-yl)-6-fluoro-8-methyl-4 -((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthonitrile; 8-(1-((2S,4S)-2-(cyanomethyl)-1-(2-fluoroacryloyl)piperidin-4-yl)-6-fluoro-8-methyl-4-((S)-1- ((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthonitrile; 8-(1-((2S,4S)-2-(cyanomethyl)-1-((E)-4-methoxybut-2-enoyl)piperidin-4-yl)-6-fluoro-8-methyl-4- ((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthonitrile; 8-(1-((2S,4S)-2-(cyanomethyl)-1-((E)-4-fluorobut-2-enoyl)piperidin-4-yl)-4-(3-(dimethylamino) -3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthonitrile; 8-(1-((2S,4S)-2-(cyanomethyl)-1-(2-fluoroacryloyl)piperidin-4-yl)-4-(3-(dimethylamino)-3-methylazetidine-1 -yl)-6-fluoro-8-methyl-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthonitrile; 8-(1-((2S,4S)-1-(but-2-ynoyl)-2-(cyanomethyl)piperidin-4-yl)-4-(3-(dimethylamino)-3-methylazetidine- 1-yl)-6-fluoro-8-methyl-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthonitrile; 8-(1-((2S,4S)-2-(cyanomethyl)-1-((E)-4-methoxybut-2-enoyl)piperidin-4-yl)-4-(3-(dimethylamino)- 3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthonitrile; 8-(1-((2S,4S)-2-(cyanomethyl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-4-yl)-4-(3-( dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthonitrile; 2-((2S,4S)-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)- 6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl) -6-fluoro-8-methyl-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl) -6-fluoro-8-methyl-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl) -6-fluoro-8-methyl-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl ) acetonitrile; 2-((2S,4S)-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-8-methyl-4-((S)-1-((S )-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidine-2 -yl) acetonitrile; 2-((2S,4S)-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-8-methyl-4-((S)-1-((S )-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-8-methyl-4- ((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-8-methyl-4-((S)-1-((S )-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidine-2- yl) acetonitrile; 2-((2S,4S)-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-8-methyl-4-((S)-1-((S )-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl) piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)- 6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)- 6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-( dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)- 6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)- 6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidine) -2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-4- (((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidine) -2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidine) -2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl) acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidine- 1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-( dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidine- 1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidine- 1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl ) acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-6-fluoro-4-((S)-1-((S)-1-methyl) pyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-6-fluoro-4-((S)-1-((S)-1-methyl) pyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-6-fluoro-4-((S)- 1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin...

Claims

1. A compound of formula I: 【Chemical Formula 1】 or a pharmaceutically acceptable salt thereof (wherein, each [Chemical Formula 2] represents, independently, a single bond or a double bond; X is N or CR ７ and; Y is N or C; R １ is H, D, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, halo, CN, OR ａ１ , SR ａ１ , C(O)R ｂ１ , C(O)NR ｃ１ R ｄ１ , C(O)OR ａ１ , OC(O)R ｂ１ , OC(O)NR ｃ１ R ｄ１ , NR ｃ１ R ｄ１ , NR ｃ１ C(O)R ｂ１ , NR ｃ１ C(O)OR ａ１ , NR ｃ１ , C(O)NR ｃ１ R ｄ１ , NR ｃ１ , S(O)R ｂ１ , NR ｃ１ , S(O) ２ R ｂ１ , NR ｃ１ , S(O) ２ , NR ｃ１ R ｄ１ , S(O)R ｂ１ , S(O)NR ｃ１ R ｄ１ , S(O) ２ R ｂ１ , S(O) ２ , NR ｃ１ R ｄ１ , and BR ｈ１ R ｉ１ is selected from, and the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl are each, R ｇ optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R ２ is H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-alkylene, C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-alkylene, C １～３ alkylene, halo, D, CN, NO ２ , OR ａ２ , SR ａ２ , C(O)R ｂ２ , C(O)NR ｃ２ R ｄ２ , C(O)OR ａ２ , OC(O)R ｂ２ , OC(O)NR ｃ２ R ｄ２ , NR ｃ２ R ｄ２ , NR ｃ２ C(O)R ｂ２ , NR ｃ２ C(O)OR ａ２ , NR ｃ２ C(O)NR ｃ２ R ｄ２ , C(=NR ｅ２ ), R ｂ２ , C(=NOR ａ２ ), R ｂ２ , C(=NR ｅ２ , NR ｃ２ R ｄ２ , NR ｃ２ , C(=NR ｅ２ , NR ｃ２ R ｄ２ , NR ｃ２ , C(=NR ｅ２ ), R ｂ２ , NR ｃ２ , S(O)R ｂ２ , NR ｃ２ , S(O) ２ R ｂ２ , NR ｃ２ , S(O) ２ NR ｃ２ R ｄ２ 、 S(O)R ｂ２ 、 S(O)NR ｃ２ R ｄ２ 、 S(O) ２ R ｂ２ 、 S(O) ２ NR ｃ２ R ｄ２ 、 and BR ｈ２ R ｉ２ selected from, wherein said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, said 5- to 10-membered heteroaryl, said C ３～１０ cycloalkyl-C １～３ alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ alkylene, said C ６～１０ aryl-C １～３ alkylene, and said 5- to 10-membered heteroaryl-C １～３ alkylene may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ２２ ; Cy １ is selected from C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, wherein the 4- to 10-membered heterocycloalkyl and the 5- to 10-membered heteroaryl each have at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S, wherein the N and the S may be oxidized, and the ring-forming carbon atoms of the 5- to 10-membered heteroaryl and the 4- to 10-membered heterocycloalkyl may be substituted by oxo to form a carbonyl group, and the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R １０ ; R ３ is H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-alkylene, C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-alkylene, C １～３ alkylene, halo, D, CN, NO ２ , OR ｆ３ , SR ａ３ , C(O)R ｂ３ , C(O)NR ｃ３ R ｄ３ , C(O)OR ａ３ , OC(O)R ｂ３ , OC(O)NR ｃ３ R ｄ３ , NR ｃ３ R ｊ３ , NR ｃ３ C(O)R ｂ３ , NR ｃ３ C(O)OR ａ３ , NR ｃ３ C(O)NR ｃ３ R ｄ３ , C(=NR ｅ３ ), R ｂ３ , C(=NOR ａ３ ), R ｂ３ , C(=NR ｅ３ ), NR ｃ３ R ｄ３ , NR ｃ３ C(=NR ｅ３ ), NR ｃ３ R ｄ３ , NR ｃ３ C(=NR ｅ３ ), R ｂ３ , NR ｃ３ , S(O)R ｂ３ , NR ｃ３ , S(O) ２ R ｂ３ , NR ｃ３ , S(O) ２ NR ｃ３ R ｄ３ 、 S(O)R ｂ３ 、 S(O)NR ｃ３ R ｄ３ 、 S(O) ２ R ｂ３ 、 S(O) ２ NR ｃ３ R ｄ３ 、 and BR ｈ３ R ｉ３ selected from, said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, said 5- to 10-membered heteroaryl, said C ３～１０ cycloalkyl-C １～３ alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ alkylene, said C ６～１０ aryl-C １～３ alkylene, and said 5- to 10-membered heteroaryl-C １～３ alkylene may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ３０ ; [Chemical Formula 3] When Y is C and the bond is a single bond, YR ６ is selected from C=O and C=S; R ４ is H, D, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～６ cycloalkyl, 4- to 6-membered heterocycloalkyl, phenyl, 5- to 6-membered heteroaryl, halo, CN, OR ａ４ , SR ａ４ , C(O)R ｂ４ , C(O)NR ｃ４ R ｄ４ , C(O)OR ａ４ , OC(O)R ｂ４ , OC(O)NR ｃ４ R ｄ４ , NR ｃ４ R ｄ４ , NR ｃ４ C(O)R ｂ４ , NR ｃ４ C(O)OR ａ４ , NR ｃ４ C(O)NR ｃ４ R ｄ４ , NR ｃ４ , NR ｂ４ , NR ｃ４ , S(O)R ２ R ｂ４ , NR ｃ４ , S(O) ２ , NR ｃ４ R ｄ４ , S(O)R ｂ４ , S(O)NR ｃ４ R ｄ４ , S(O) ２ R ｂ４ , S(O) ２ , NR ｃ４ R ｄ４ , and BR ｈ４ R ｉ４ is selected from, and the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～６ cycloalkyl, the 4- to 6-membered heterocycloalkyl, the phenyl, and the 5- to 6-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ｇ ; R ５ is H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-alkylene, C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-alkylene, C １～３ alkylene, halo, D, CN, NO ２ , OR ａ５ , SR ａ５ , C(O)R ｂ５ , C(O)NR ｃ５ R ｄ５ , C(O)OR ａ５ , OC(O)R ｂ５ , OC(O)NR ｃ５ R ｄ５ , NR ｃ５ R ｄ５ , NR ｃ５ C(O)R ｂ５ , NR ｃ５ C(O)OR ａ５ , NR ｃ５ C(O)NR ｃ５ R ｄ５ , C(=NR ｅ５ ), R ｂ５ , C(=NOR ａ５ ), R ｂ５ , C(=NR ｅ５ ), NR ｃ５ R ｄ５ , NR ｃ５ C(=NR ｅ５ ), NR ｃ５ R ｄ５ , NR ｃ５ C(=NR ｅ５ ), R ｂ５ , NR ｃ５ , NR ｂ５ , NR ｃ５ , NR ２ R ｂ５ , NR ｃ５ , NR ２ NR ｃ５ R ｄ５ 、 S(O)R ｂ５ 、 S(O)NR ｃ５ R ｄ５ 、 S(O) ２ R ｂ５ 、 S(O) ２ NR ｃ５ R ｄ５ 、 and BR ｈ５ R ｉ５ selected from, said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, said 5- to 10-membered heteroaryl, said C ３～１０ cycloalkyl-C １～３ alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ alkylene, said C ６～１０ aryl-C １～３ alkylene, and said 5- to 10-membered heteroaryl-C １～３ alkylene may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ５０ ; [Chemical Formula 4] is a double bond and when Y is N, R ４ and R ６ do not exist; 【Chemical Formula 5】 When it is a double bond and Y is C, R ４ does not exist; R ６ is H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-alkylene, C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-alkylene, C １～３ alkylene, halo, D, CN, NO ２ , OR ａ６ , SR ａ６ , C(O)R ｂ６ , C(O)NR ｃ６ R ｄ６ , C(O)OR ａ６ , OC(O)R ｂ６ , OC(O)NR ｃ６ R ｄ６ , NR ｃ６ R ｄ６ , NR ｃ６ C(O)R ｂ６ , NR ｃ６ C(O)OR ａ６ , NR ｃ６ C(O)NR ｃ６ R ｄ６ , C(=NR ｅ６ ), R ｂ６ , C(=NOR ａ６ ), R ｂ６ , C(=NR ｅ６ ), NR ｃ６ R ｄ６ , NR ｃ６ , C(=NR ｅ６ ), NR ｃ６ R ｄ６ , NR ｃ６ , C(=NR ｅ６ ), R ｂ６ , NR ｃ６ , S(O)R ｂ６ , NR ｃ６ , S(O) ２ R ｂ６ , NR ｃ６ , S(O) ２ NR ｃ６ R ｄ６ 、 S(O)R ｂ６ 、 S(O)NR ｃ６ R ｄ６ 、 S(O) ２ R ｂ６ 、 S(O) ２ NR ｃ６ R ｄ６ 、 and BR ｈ６ R ｉ６ selected from, said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, said 5- to 10-membered heteroaryl, said C ３～１０ cycloalkyl-C １～３ alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ alkylene, said C ６～１０ aryl-C １～３ alkylene, and said 5- to 10-membered heteroaryl-C １～３ alkylene may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ６０ ; R ７ is H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-alkylene, C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-alkylene, C １～３ alkylene, halo, D, CN, NO ２ , OR ａ７ , SR ａ７ , C(O)R ｂ７ , C(O)NR ｃ７ R ｄ７ , C(O)OR ａ７ , OC(O)R ｂ７ , OC(O)NR ｃ７ R ｄ７ , NR ｃ７ R ｄ７ , NR ｃ７ , NR ｂ７ , NR ｃ７ , NR ａ７ , NR ｃ７ , NR ｃ７ R ｄ７ , C(=NR ｅ７ ), R ｂ７ , C(=NOR ａ７ ), R ｂ７ , C(=NR ｅ７ ), NR ｃ７ R ｄ７ , NR ｃ７ , NR ｅ７ , NR ｃ７ R ｄ７ , NR ｃ７ , NR ｅ７ , NR ｂ７ , NR ｃ７ , NR ｂ７ , NR ｃ７ , NR ２ R ｂ７ , NR ｃ７ , NR ２ NR ｃ７ R ｄ７ 、 S(O)R ｂ７ 、 S(O)NR ｃ７ R ｄ７ 、 S(O) ２ R ｂ７ 、 S(O) ２ NR ｃ７ R ｄ７ 、 and BR ｈ７ R ｉ７ selected from, wherein said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, said 5- to 10-membered heteroaryl, said C ３～１０ cycloalkyl-C １～３ alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ alkylene, said C ６～１０ aryl-C １～３ alkylene, and said 5- to 10-membered heteroaryl-C １～３ alkylene may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ７０ ; Cy ２ is selected from C ３～１０ cycloalkyl, 4- to 14-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, wherein the 4- to 14-membered heterocycloalkyl and the 5- to 10-membered heteroaryl each have at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S, wherein the N and the S may be oxidized, and the ring-forming carbon atoms of the 5- to 10-membered heteroaryl and the 4- to 14-membered heterocycloalkyl may be substituted by oxo to form a carbonyl group, and the C ３～１０ cycloalkyl, the 4- to 14-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ２０ ; Each R １０ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, NO ２ , OR ａ１０ , SR ａ１０ , C(O)R ｂ１０ , C(O)NR ｃ１０ R ｄ１０ , C(O)OR ａ１０ , OC(O)R ｂ１０ , OC(O)NR ｃ１０ R ｄ１０ , NR ｃ１０ R ｄ１０ , NR ｃ１０ C(O)R ｂ１０ , NR ｃ１０ C(O)OR ａ１０ , NR ｃ１０ C(O)NR ｃ１０ R ｄ１０ , C(=NR ｅ１０ )R ｂ１０ , C(=NOR ａ１０ )R ｂ１０ , C(=NR ｅ１０ )NR ｃ１０ R ｄ１０ , NR ｃ１０ C(=NR ｅ１０ )NR ｃ１０ R ｄ１０ , NR ｃ１０ S(O)R ｂ１０ , NR ｃ１０ S(O) ２ R ｂ１０ , NR ｃ１０ S(O) ２ NR ｃ１０ R ｄ１０ , S(O)R ｂ１０ , SONR ｃ１０ R ｄ１０ , S(O) ２ R ｂ１０ , S(O) ２ NR ｃ１０ R ｄ１０ , and BR ｈ１０ R ｉ１０ is independently selected from, said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, said 5- to 10-membered heteroaryl, said C ３～１０ cycloalkyl-C １～３ alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ alkylene, said C ６～１０ aryl-C １～３ alkylene, and said 5- to 10-membered heteroaryl-C １～３ alkylene may each be substituted with 1, 2, 3, or 4 substituents independently selected from R １１ ; Each R １１ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, OR ａ１１ , SR ａ１１ , C(O)R ｂ１１ , C(O)NR ｃ１１ R ｄ１１ , C(O)OR ａ１１ , OC(O)R ｂ１１ , OC(O)NR ｃ１１ R ｄ１１ , NR ｃ１１ R ｄ１１ , NR ｃ１１ C(O)R ｂ１１ , NR ｃ１１ C(O)OR ａ１１ , NR ｃ１１ C(O)NR ｃ１１ R ｄ１１ , NR ｃ１１ , S(O)R ｂ１１ , NR ｃ１１ , S(O) ２ R ｂ１１ , NR ｃ１１ , S(O) ２ , NR ｃ１１ R ｄ１１ , S(O)R ｂ１１ , S(O)NR ｃ１１ R ｄ１１ , S(O) ２ R ｂ１１ , S(O) ２ , NR ｃ１１ R ｄ１１ , and BR ｈ１１ R ｉ１１ is independently selected from, said C １～６ alkyl, said C ２～６ Alkenyl, said C ２～６ Alkynyl, said C ３～１０ Cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ Aryl, said 5- to 10-membered heteroaryl, said C ３～１０ Cycloalkyl-C １～３ Alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ Alkylene, said C ６～１０ Aryl-C １～３ Alkylene, and said 5- to 10-membered heteroaryl-C １～３ Each of the alkylene may be substituted with 1, 2, 3, or 4 substituents independently selected from R １２ and may be; Each R １２ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～６ cycloalkyl, phenyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, halo, D, CN, OR ａ１２ , SR ａ１２ , C(O)R ｂ１２ , C(O)NR ｃ１２ R ｄ１２ , C(O)OR ａ１２ , OC(O)R ｂ１２ , OC(O)NR ｃ１２ R ｄ１２ , NR ｃ１２ R ｄ１２ , NR ｃ１２ C(O)R ｂ１２ , NR ｃ１２ C(O)OR ａ１２ , NR ｃ１２ C(O)NR ｃ１２ R ｄ１２ , NR ｃ１２ S(O)R ｂ１２ , NR ｃ１２ , NR ２ S(O) ｂ１２ , NR ｃ１２ , S(O) ２ , NR ｃ１２ R ｄ１２ , S(O)R ｂ１２ , S(O)NR ｃ１２ R ｄ１２ , S(O) ２ R ｂ１２ , S(O) ２ , NR ｃ１２ R ｄ１２ , and BR ｈ１２ R ｉ１２ is independently selected from, and each of said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～６ cycloalkyl, said phenyl, said 5- to 6-membered heteroaryl, and said 4- to 7-membered heterocycloalkyl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ｇ ; Each R ２０ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, NO ２ , OR ａ２０ , SR ａ２０ , C(O)R ｂ２０ , C(O)NR ｃ２０ R ｄ２０ , C(O)OR ａ２０ , OC(O)R ｂ２０ , OC(O)NR ｃ２０ R ｄ２０ , NR ｃ２０ R ｄ２０ , NR ｃ２０ C(O)R ｂ２０ , NR ｃ２０ C(O)OR ａ２０ , NR ｃ２０ C(O)NR ｃ２０ R ｄ２０ , C(=NR ｅ２０ )R ｂ２０ , C(=NOR ａ２０ )R ｂ２０ , C(=NR ｅ２０ )NR ｃ２０ R ｄ２０ , NR ｃ２０ C(=NR ｅ２０ )NR ｃ２０ R ｄ２０ , NR ｃ２０ S(O)R ｂ２０ , NR ｃ２０ S(O) ２ R ｂ２０ , NR ｃ２０ S(O) ２ NR ｃ２０ R ｄ２０ , S(O)R ｂ２０ , SONR ｃ２０ R ｄ２０ , S(O) ２ R ｂ２０ , S(O) ２ NR ｃ２０ R ｄ２０ , and BR ｈ２０ R ｉ２０ is independently selected from, said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, said 5- to 10-membered heteroaryl, said C ３～１０ cycloalkyl-C １～３ alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ alkylene, said C ６～１０ aryl-C １～３ alkylene, and said 5- to 10-membered heteroaryl-C １～３ alkylene may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ２１ ; Each R ２１ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, OR ａ２１ , SR ａ２１ , C(O)R ｂ２１ , C(O)NR ｃ２１ R ｄ２１ , C(O)OR ａ２１ , OC(O)R ｂ２１ , OC(O)NR ｃ２１ R ｄ２１ , NR ｃ２１ R ｄ２１ , NR ｃ２１ C(O)R ｂ２１ , NR ｃ２１ C(O)OR ａ２１ , NR ｃ２１ C(O)NR ｃ２１ R ｄ２１ , NR ｃ２１ , S(O)R ｂ２１ , NR ｃ２１ , S(O) ２ R ｂ２１ , NR ｃ２１ , S(O) ２ , NR ｃ２１ R ｄ２１ , S(O)R ｂ２１ , S(O)NR ｃ２１ R ｄ２１ , S(O) ２ R ｂ２１ , S(O) ２ , NR ｃ２１ R ｄ２１ , and BR ｈ２１ R ｉ２１ is independently selected from, said C １～６ alkyl, said C ２～６ Alkenyl, said C ２～６ Alkynyl, said C ３～１０ Cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ Aryl, said 5- to 10-membered heteroaryl, said C ３～１０ Cycloalkyl-C １～３ Alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ Alkylene, said C ６～１０ Aryl-C １～３ Alkylene, and said 5- to 10-membered heteroaryl-C １～３ The alkylene groups may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ｇ ; and may be substituted; Each R ２２ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, NO ２ , OR ａ２２ , SR ａ２２ , C(O)R ｂ２２ , C(O)NR ｃ２２ R ｄ２２ , C(O)OR ａ２２ , OC(O)R ｂ２２ , OC(O)NR ｃ２２ R ｄ２２ , NR ｃ２２ R ｄ２２ , NR ｃ２２ C(O)R ｂ２２ , NR ｃ２２ C(O)OR ａ２２ , NR ｃ２２ C(O)NR ｃ２２ R ｄ２２ , NR ｃ２２ S(O)R ｂ２２ , NR ｃ２２ , S(O) ２ R ｂ２２ , NR ｃ２２ , S(O) ２ , NR ｃ２２ R ｄ２２ , S(O)R ｂ２２ , S(O)NR ｃ２２ R ｄ２２ , S(O) ２ R ｂ２２ , S(O) ２ , NR ｃ２２ R ｄ２２ , and BR ｈ２２ R ｉ２２ is independently selected from, said C １～６ alkyl, said C ２～６ Alkenyl, said C ２～６ Alkynyl, said C ３～１０ Cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ Aryl, said 5- to 10-membered heteroaryl, said C ３～１０ Cycloalkyl-C １～３ Alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ Alkylene, said C ６～１０ Aryl-C １～３ Alkylene, and said 5- to 10-membered heteroaryl-C １～３ Each of the alkylene may be substituted with 1, 2, 3, or 4 substituents independently selected from R ２３ and may be; Each R ２３ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, OR ａ２３ , SR ａ２３ , C(O)R ｂ２３ , C(O)NR ｃ２３ R ｄ２３ , C(O)OR ａ２３ , OC(O)R ｂ２３ , OC(O)NR ｃ２３ R ｄ２３ , NR ｃ２３ R ｄ２３ , NR ｃ２３ C(O)R ｂ２３ , NR ｃ２３ C(O)OR ａ２３ , NR ｃ２３ C(O)NR ｃ２３ R ｄ２３ , NR ｃ２３ , S(O)R ｂ２３ , NR ｃ２３ , S(O) ２ R ｂ２３ , NR ｃ２３ , S(O) ２ , NR ｃ２３ R ｄ２３ , S(O)R ｂ２３ , S(O)NR ｃ２３ R ｄ２３ , S(O) ２ R ｂ２３ , S(O) ２ , NR ｃ２３ R ｄ２３ , and BR ｈ２３ R ｉ２３ is independently selected from, said C １～６ alkyl, said C ２～６ Alkenyl, said C ２～６ Alkynyl, said C ３～１０ Cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ Aryl, said 5- to 10-membered heteroaryl, said C ３～１０ Cycloalkyl-C １～３ Alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ Alkylene, said C ６～１０ Aryl-C １～３ Alkylene, and said 5- to 10-membered heteroaryl-C １～３ Each of the alkylene may be substituted with 1, 2, 3, or 4 substituents independently selected from R ２４ and may be; Each R ２４ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～６ cycloalkyl, phenyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, halo, D, CN, OR ａ２４ , SR ａ２４ , C(O)R ｂ２４ , C(O)NR ｃ２４ R ｄ２４ , C(O)OR ａ２４ , OC(O)R ｂ２４ , OC(O)NR ｃ２４ R ｄ２４ , NR ｃ２４ R ｄ２４ , NR ｃ２４ , NR ｂ２４ , NR ｃ２４ , NR ａ２４ , NR ｃ２４ , NR ｃ２４ R ｄ２４ , NR ｃ２４ , NR ｂ２４ , NR ｃ２４ , NR ２ R ｂ２４ , NR ｃ２４ , NR ２ , NR ｃ２４ R ｄ２４ , NR ｂ２４ , NR ｃ２４ R ｄ２４ , NR ２ R ｂ２４ , NR ２ , NR ｃ２４ R ｄ２４ , and BR ｈ２４ R ｉ２４ is independently selected from, and the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～６ cycloalkyl, the phenyl, the 5- to 6-membered heteroaryl, and the 4- to 7-membered heterocycloalkyl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ｇ ; Each R ３０ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, NO ２ , OR ａ３０ , SR ａ３０ , C(O)R ｂ３０ , C(O)NR ｃ３０ R ｄ３０ , C(O)OR ａ３０ , OC(O)R ｂ３０ , OC(O)NR ｃ３０ R ｄ３０ , NR ｃ３０ R ｄ３０ , NR ｃ３０ C(O)R ｂ３０ , NR ｃ３０ C(O)OR ａ３０ , NR ｃ３０ C(O)NR ｃ３０ R ｄ３０ , NR ｃ３０ S(O)R ｂ３０ , NR ｃ３０ S(O) ２ R ｂ３０ , NR ｃ３０ S(O) ２ NR ｃ３０ R ｄ３０ , S(O)R ｂ３０ , S(O)NR ｃ３０ R ｄ３０ , S(O) ２ R ｂ３０ , S(O) ２ NR ｃ３０ R ｄ３０ , and BR ｈ３０ R ｉ３０ is independently selected from, said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, said 5- to 10-membered heteroaryl, said C ３～１０ cycloalkyl-C １～３ alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ alkylene, said C ６～１０ aryl-C １～３ alkylene, and said 5- to 10-membered heteroaryl-C １～３ Each of the alkylene may be substituted with 1, 2, 3, or 4 substituents independently selected from R ３１ and may be; Each R ３１ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, OR ａ３１ , SR ａ３１ , C(O)R ｂ３１ , C(O)NR ｃ３１ R ｄ３１ , C(O)OR ａ３１ , OC(O)R ｂ３１ , OC(O)NR ｃ３１ R ｄ３１ , NR ｃ３１ R ｄ３１ , NR ｃ３１ C(O)R ｂ３１ , NR ｃ３１ C(O)OR ａ３１ , NR ｃ３１ C(O)NR ｃ３１ R ｄ３１ , NR ｃ３１ , S(O)R ｂ３１ , NR ｃ３１ , S(O) ２ R ｂ３１ , NR ｃ３１ , S(O) ２ , NR ｃ３１ R ｄ３１ , S(O)R ｂ３１ , S(O)NR ｃ３１ R ｄ３１ , S(O) ２ R ｂ３１ , S(O) ２ , NR ｃ３１ R ｄ３１ , and BR ｈ３１ R ｉ３１ is independently selected from, said C １～６ alkyl, said C ２～６ Alkenyl, said C ２～６ Alkynyl, said C ３～１０ Cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ Aryl, said 5- to 10-membered heteroaryl, said C ３～１０ Cycloalkyl-C １～３ Alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ Alkylene, said C ６～１０ Aryl-C １～３ Alkylene, and said 5- to 10-membered heteroaryl-C １～３ Each of the alkylene is optionally substituted with 1, 2, 3, or 4 substituents independently selected from R ３２ and may be; Each R ３２ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～６ cycloalkyl, phenyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, halo, D, CN, OR ａ３２ , SR ａ３２ , C(O)R ｂ３２ , C(O)NR ｃ３２ R ｄ３２ , C(O)OR ａ３２ , OC(O)R ｂ３２ , OC(O)NR ｃ３２ R ｄ３２ , NR ｃ３２ R ｄ３２ , NR ｃ３２ , C(O)R ｂ３２ , NR ｃ３２ , C(O)OR ａ３２ , NR ｃ３２ , C(O)NR ｃ３２ R ｄ３２ , NR ｃ３２ , NR ｂ３２ , NR ｃ３２ , NR ２ R ｂ３２ , NR ｃ３２ , NR ２ , NR ｃ３２ R ｄ３２ , S(O)R ｂ３２ , S(O)NR ｃ３２ R ｄ３２ , S(O)R ２ R ｂ３２ , S(O)R ２ , S(O)NR ｃ３２ R ｄ３２ , and BR ｈ３２ R ｉ３２ is independently selected from, and the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～６ cycloalkyl, the phenyl, the 5- to 6-membered heteroaryl, and the 4- to 7-membered heterocycloalkyl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ｇ ; Each R ５０ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, OR ａ５０ , SR ａ５０ , C(O)R ｂ５０ , C(O)NR ｃ５０ R ｄ５０ , C(O)OR ａ５０ , OC(O)R ｂ５０ , OC(O)NR ｃ５０ R ｄ５０ , NR ｃ５０ R ｄ５０ , NR ｃ５０ C(O)R ｂ５０ , NR ｃ５０ , C(O)OR ａ５０ , NR ｃ５０ , C(O)NR ｃ５０ R ｄ５０ , NR ｃ５０ , S(O)R ｂ５０ , NR ｃ５０ , S(O) ２ R ｂ５０ , NR ｃ５０ , S(O) ２ , NR ｃ５０ R ｄ５０ , S(O)R ｂ５０ , S(O)NR ｃ５０ R ｄ５０ , S(O) ２ R ｂ５０ , S(O) ２ , NR ｃ５０ R ｄ５０ , and BR ｈ５０ R ｉ５０ is independently selected from, said C １～６ alkyl, said C ２～６ Alkenyl, said C ２～６ Alkynyl, said C ３～１０ Cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ Aryl, said 5- to 10-membered heteroaryl, said C ３～１０ Cycloalkyl-C １～３ Alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ Alkylene, said C ６～１０ Aryl-C １～３ Alkylene, and said 5- to 10-membered heteroaryl-C １～３ Each of the alkylene may be substituted with 1, 2, 3, or 4 substituents independently selected from R ５１ and may be substituted; Each R ５１ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～６ cycloalkyl, C ６～１０ aryl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, halo, D, CN, OR ａ５１ , SR ａ５１ , C(O)R ｂ５１ , C(O)NR ｃ５１ R ｄ５１ , C(O)OR ａ５１ , OC(O)R ｂ５１ , OC(O)NR ｃ５１ R ｄ５１ , NR ｃ５１ R ｄ５１ , NR ｃ５１ C(O)R ｂ５１ , NR ｃ５１ C(O)OR ａ５１ , NR ｃ５１ C(O)NR ｃ５１ R ｄ５１ , NR ｃ５１ S(O)R ｂ５１ , NR ｃ５１ S(O) ２ R ｂ５１ , NR ｃ５１ S(O) ２ , NR ｃ５１ R ｄ５１ , S(O)R ｂ５１ , S(O)NR ｃ５１ R ｄ５１ , S(O) ２ R ｂ５１ , S(O) ２ , NR ｃ５１ R ｄ５１ , and BR ｈ５１ R ｉ５１ is independently selected from, and the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～６ cycloalkyl, the C ６～１０ aryl, the 5- to 6-membered heteroaryl, and the 4- to 7-membered heterocycloalkyl are each, R ５２ optionally substituted with 1, 2, 3, or 4 substituents independently selected from; Each R ５２ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～６ cycloalkyl, phenyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, halo, D, CN, OR ａ５２ , SR ａ５２ , C(O)R ｂ５２ , C(O)NR ｃ５２ R ｄ５２ , C(O)OR ａ５２ , OC(O)R ｂ５２ , OC(O)NR ｃ５２ R ｄ５２ , NR ｃ５２ R ｄ５２ , NR ｃ５２ C(O)R ｂ５２ , NR ｃ５２ C(O)OR ａ５２ , NR ｃ５２ C(O)NR ｃ５２ R ｄ５２ , NR ｃ５２ S(O)R ｂ５２ , NR ｃ５２ , NR ２ R ｂ５２ , NR ｃ５２ , NR ２ R ｃ５２ , S(O)R ｄ５２ , S(O)NR ｂ５２ R ｃ５２ , S(O) ｄ５２ , S(O) ２ R ｂ５２ , S(O) ２ , NR ｃ５２ R ｄ５２ , and BR ｈ５２ R ｉ５２ is independently selected from, and the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～６ cycloalkyl, the phenyl, the 5- to 6-membered heteroaryl, and the 4- to 7-membered heterocycloalkyl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ｇ ; Each R ６０ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, NO ２ , OR ａ６０ , SR ａ６０ , C(O)R ｂ６０ , C(O)NR ｃ６０ R ｄ６０ , C(O)OR ａ６０ , OC(O)R ｂ６０ , OC(O)NR ｃ６０ R ｄ６０ , NR ｃ６０ R ｄ６０ , NR ｃ６０ C(O)R ｂ６０ , NR ｃ６０ C(O)OR ａ６０ , NR ｃ６０ C(O)NR ｃ６０ R ｄ６０ , NR ｃ６０ S(O)R ｂ６０ , NR ｃ６０ S(O) ２ R ｂ６０ , NR ｃ６０ S(O) ２ NR ｃ６０ R ｄ６０ , S(O)R ｂ６０ , S(O)NR ｃ６０ R ｄ６０ , S(O) ２ R ｂ６０ , S(O) ２ NR ｃ６０ R ｄ６０ , and BR ｈ６０ R ｉ６０ is independently selected from, said C １～６ alkyl, said C ２～６ Alkenyl, said C ２～６ Alkynyl, said C ３～１０ Cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ Aryl, said 5- to 10-membered heteroaryl, said C ３～１０ Cycloalkyl-C １～３ Alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ Alkylene, said C ６～１０ Aryl-C １～３ Alkylene, and said 5- to 10-membered heteroaryl-C １～３ Each of the alkylene may be substituted with 1, 2, 3, or 4 substituents independently selected from R ６１ and may be; Each R ６１ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, OR ａ６１ , SR ａ６１ , C(O)R ｂ６１ , C(O)NR ｃ６１ R ｄ６１ , C(O)OR ａ６１ , OC(O)R ｂ６１ , OC(O)NR ｃ６１ R ｄ６１ , NR ｃ６１ R ｄ６１ , NR ｃ６１ C(O)R ｂ６１ , NR ｃ６１ C(O)OR ａ６１ , NR ｃ６１ C(O)NR ｃ６１ R ｄ６１ , NR ｃ６１ , NR ｂ６１ , NR ｃ６１ , NR ２ R ｂ６１ , NR ｃ６１ , NR ２ , NR ｃ６１ R ｄ６１ , S(O)R ｂ６１ , S(O)NR ｃ６１ R ｄ６１ , S(O) ２ R ｂ６１ , S(O) ２ , S(O)NR ｃ６１ R ｄ６１ , and BR ｈ６１ R ｉ６１ is independently selected from, said C １～６ alkyl, said C ２～６ Alkenyl, said C ２～６ Alkynyl, said C ３～１０ Cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ Aryl, said 5- to 10-membered heteroaryl, said C ３～１０ Cycloalkyl-C １～３ Alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ Alkylene, said C ６～１０ Aryl-C １～３ Alkylene, and said 5- to 10-membered heteroaryl-C １～３ The alkylene groups may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ６２ and may be substituted; Each R ６２ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～６ cycloalkyl, phenyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, halo, D, CN, OR ａ６２ , SR ａ６２ , C(O)R ｂ６２ , C(O)NR ｃ６２ R ｄ６２ , C(O)OR ａ６２ , OC(O)R ｂ６２ , OC(O)NR ｃ６２ R ｄ６２ , NR ｃ６２ R ｄ６２ , NR ｃ６２ C(O)R ｂ６２ , NR ｃ６２ C(O)OR ａ６２ , NR ｃ６２ C(O)NR ｃ６２ R ｄ６２ , NR ｃ６２ S(O)R ｂ６２ , NR ｃ６２ , S(O) ２ R ｂ６２ , NR ｃ６２ , S(O) ２ , NR ｃ６２ R ｄ６２ , S(O)R ｂ６２ , S(O)NR ｃ６２ R ｄ６２ , S(O) ２ R ｂ６２ , S(O) ２ , NR ｃ６２ R ｄ６２ , and BR ｈ６２ R ｉ６２ is independently selected from, and each of said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～６ cycloalkyl, said phenyl, said 5- to 6-membered heteroaryl, and said 4- to 7-membered heterocycloalkyl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ｇ ; Each R ７０ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, NO ２ , OR ａ７０ , SR ａ７０ , C(O)R ｂ７０ , C(O)NR ｃ７０ R ｄ７０ , C(O)OR ａ７０ , OC(O)R ｂ７０ , OC(O)NR ｃ７０ R ｄ７０ , NR ｃ７０ R ｄ７０ , NR ｃ７０ C(O)R ｂ７０ , NR ｃ７０ C(O)OR ａ７０ , NR ｃ７０ C(O)NR ｃ７０ R ｄ７０ , NR ｃ７０ S(O)R ｂ７０ , NR ｃ７０ S(O) ２ R ｂ７０ , NR ｃ７０ S(O) ２ NR ｃ７０ R ｄ７０ , S(O)R ｂ７０ , S(O)NR ｃ７０ R ｄ７０ , S(O) ２ R ｂ７０ , S(O) ２ , NR ｃ７０ R ｄ７０ , and BR ｈ７０ R ｉ７０ is independently selected from, said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, said 5- to 10-membered heteroaryl, said C ３～１０ cycloalkyl-C １～３ alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ alkylene, said C ６～１０ aryl-C １～３ alkylene, and said 5- to 10-membered heteroaryl-C １～３ Each of the alkylene may be substituted with 1, 2, 3, or 4 substituents independently selected from R ７１ and may be; Each R ７１ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, OR ａ７１ , SR ａ７１ , C(O)R ｂ７１ , C(O)NR ｃ７１ R ｄ７１ , C(O)OR ａ７１ , OC(O)R ｂ７１ , OC(O)NR ｃ７１ R ｄ７１ , NR ｃ７１ R ｄ７１ , NR ｃ７１ C(O)R ｂ７１ , NR ｃ７１ C(O)OR ａ７１ , NR ｃ７１ C(O)NR ｃ７１ R ｄ７１ , NR ｃ７１ , S(O)R ｂ７１ , NR ｃ７１ , S(O) ２ R ｂ７１ , NR ｃ７１ , S(O) ２ , NR ｃ７１ R ｄ７１ , S(O)R ｂ７１ , S(O)NR ｃ７１ R ｄ７１ , S(O) ２ R ｂ７１ , S(O) ２ , NR ｃ７１ R ｄ７１ , and BR ｈ７１ R ｉ７１ is independently selected from, said C １～６ alkyl, said C ２～６ Alkenyl, said C ２～６ Alkynyl, said C ３～１０ Cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ Aryl, said 5- to 10-membered heteroaryl, said C ３～１０ Cycloalkyl-C １～３ Alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ Alkylene, said C ６～１０ Aryl-C １～３ Alkylene, and said 5- to 10-membered heteroaryl-C １～３ Each of the alkylene may be substituted with 1, 2, 3, or 4 substituents independently selected from R ７２ and may be; Each R ７２ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～６ cycloalkyl, phenyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, halo, D, CN, OR ａ７２ , SR ａ７２ , C(O)R ｂ７２ , C(O)NR ｃ７２ R ｄ７２ , C(O)OR ａ７２ , OC(O)R ｂ７２ , OC(O)NR ｃ７２ R ｄ７２ , NR ｃ７２ R ｄ７２ , NR ｃ７２ C(O)R ｂ７２ , NR ｃ７２ C(O)OR ａ７２ , NR ｃ７２ C(O)NR ｃ７２ R ｄ７２ , NR ｃ７２ S(O)R ｂ７２ , NR ｃ７２ S(O) ２ R ｂ７２ , NR ｃ７２ S(O) ２ , NR ｃ７２ R ｄ７２ , S(O)R ｂ７２ , S(O)NR ｃ７２ R ｄ７２ , S(O) ２ R ｂ７２ , S(O) ２ , NR ｃ７２ R ｄ７２ , and BR ｈ７２ R ｉ７２ is independently selected from, and the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～６ cycloalkyl, the phenyl, the 5- to 6-membered heteroaryl, and the 4- to 7-membered heterocycloalkyl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ｇ ; R ａ１ 、 R ｂ１ 、 R ｃ１ 、 and R ｄ１ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ｇ ; or Alternatively, any R and R attached to the same N atom, together with the N atom to which they are attached, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; ｃ１ and R ｄ１ are attached to the N atom to which they are attached, together with the N atom to which they are attached, R ｇ from which 1, 2, or 3 substituents independently selected may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with; R ｈ１ and R ｉ１ each is independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ１ and R ｉ１ bonded to the same B atom, together with the B atom to which they are bonded, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ２ 、 R ｂ２ 、 R ｃ２ 、 and R ｄ２ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ２２ ; Alternatively, any R and R bonded to the same N atom, together with the N atom to which they are bonded, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ｃ２ and R ｄ２ are, together with the N atom to which they are bonded, a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ２２ form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; Each R ｅ２ is independently selected from H, CN, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C １～６ alkylthio, C １～６ alkylsulfonyl, C １～６ alkylcarbonyl, C １～６ alkylaminosulfonyl, carbamyl, C １～６ alkylcarbamyl, di(C １～６ alkyl)carbamyl, aminosulfonyl, C １～６ alkylaminosulfonyl, and di(C １～６ alkyl)aminosulfonyl; R ｈ２ and R ｉ２ are each independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ２ and R ｉ２ bonded to the same B atom, together with said B atom to which they are bonded, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ３ 、 R ｂ３ 、 R ｃ３ 、 and R ｄ３ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, and said 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ３０ ; or Alternatively, any R and R that are attached to the same N atom, together with the N atom to which they are attached, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ｃ３ and R ｄ３ are, together with the N atom to which they are attached, a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ３０ are optionally substituted with 1, 2, 3, or 4 substituents independently selected from R to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; Each R ｅ３ is independently selected from H, CN, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C １～６ alkylthio, C １～６ alkylsulfonyl, C １～６ alkylcarbonyl, C １～６ alkylaminosulfonyl, carbamyl, C １～６ alkylcarbamyl, di(C １～６ alkyl)carbamyl, aminosulfonyl, C １～６ alkylaminosulfonyl, and di(C １～６ alkyl)aminosulfonyl; R ｆ３ and R ｊ３ are each independently selected from C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ３０ ; or Alternatively, any R and R that are attached to the same N atom, together with the N atom to which they are attached, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ｃ３ and R ｊ３ are, together with the N atom to which they are attached, a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ３０ are, together with the N atom to which they are attached, a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; R ｈ３ and R ｉ３ are each independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ３ and R ｉ３ bonded to the same B atom, together with the B atom to which they are bonded, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ４ 、 R ｂ４ 、 R ｃ４ 、 and R ｄ４ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ｇ ; Alternatively, any R and R that are attached to the same N atom, together with the N atom to which they are attached, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; ｃ４ and R ｄ４ are, together with the N atom to which they are attached, a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; ｇ or may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; R ｈ４ and R ｉ４ each independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ４ and R ｉ４ bonded to the same B atom, together with said B atom to which they are bonded, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ５ 、R ｂ５ 、R ｃ５ 、and R ｄ５ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ５０ ; Alternatively, any R and R that are attached to the same N atom, together with the N atom to which they are attached, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ｃ５ and R ｄ５ are, together with the N atom to which they are attached, a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ５０ are optionally substituted with 1, 2, 3, or 4 substituents independently selected from R to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; Each R ｅ５ is independently selected from H, CN, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C １～６ alkylthio, C １～６ alkylsulfonyl, C １～６ alkylcarbonyl, C １～６ alkylaminosulfonyl, carbamyl, C １～６ alkylcarbamyl, di(C １～６ alkyl)carbamyl, aminosulfonyl, C １～６ alkylaminosulfonyl, and di(C １～６ alkyl)aminosulfonyl; R ｈ５ and R ｉ５ each is independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R and R ｈ５ bonded to the same B atom together with the B atom to which they are bonded form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C ｉ５ alkyl and C １～６ haloalkyl; １～６ ​ R ａ６ 、R ｂ６ 、R ｃ６ 、and R ｄ６ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ６０ ; or Alternatively, any R and R bonded to the same N atom, together with the N atom to which they are bonded, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ｃ６ and R ｄ６ are, together with the N atom to which they are bonded, a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ６０ are, together with the N atom to which they are bonded, a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; Each R ｅ６ is independently selected from H, CN, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C １～６ alkylthio, C １～６ alkylsulfonyl, C １～６ alkylcarbonyl, C １～６ alkylaminosulfonyl, carbamyl, C １～６ alkylcarbamyl, di(C １～６ alkyl)carbamyl, aminosulfonyl, C １～６ alkylaminosulfonyl, and di(C １～６ alkyl)aminosulfonyl; R ｈ６ and R ｉ６ are each independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ６ and R ｉ６ bonded to the same B atom, together with the B atom to which they are bonded, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ７ 、 R ｂ７ 、 R ｃ７ 、 and R ｄ７ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ７０ ; or Alternatively, any R and R bonded to the same N atom, together with the N atom to which they are bonded, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ｃ７ and R ｄ７ are, together with the N atom to which they are bonded, a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ７０ which may be substituted with 1, 2, 3, or 4 substituents independently selected from R to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; Each R ｅ７ is independently selected from H, CN, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C １～６ alkylthio, C １～６ alkylsulfonyl, C １～６ alkylcarbonyl, C １～６ alkylaminosulfonyl, carbamyl, C １～６ alkylcarbamyl, di(C １～６ alkyl)carbamyl, aminosulfonyl, C １～６ alkylaminosulfonyl, and di(C １～６ alkyl)aminosulfonyl; R ｈ７ and R ｉ７ each is independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ７ and R ｉ７ bonded to the same B atom, together with the B atom to which they are bonded, is substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl to form a 5- or 6-membered heterocycloalkyl group which may be substituted; R ａ１０ 、 R ｂ１０ 、 R ｃ１０ 、 and R ｄ１０ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, and said 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R １１ ; or Alternatively, any R and R bonded to the same N atom together with the N atom to which they are bonded may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ｃ１０ and R ｄ１０ are, together with the N atom to which they are bonded, optionally substituted with 1, 2, 3, or 4 substituents independently selected from R to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; １１ or may be substituted with 1, 2, 3, or 4 substituents independently selected from R to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group which may be substituted; Each R ｅ１０ is independently selected from H, CN, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C １～６ alkylthio, C １～６ alkylsulfonyl, C １～６ alkylcarbonyl, C １～６ alkylaminosulfonyl, carbamyl, C １～６ alkylcarbamyl, di(C １～６ alkyl)carbamyl, aminosulfonyl, C １～６ alkylaminosulfonyl, and di(C １～６ alkyl)aminosulfonyl; R ｈ１０ and R ｉ１０ are each independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ１０ and R ｉ１０ bonded to the same B atom, together with the B atom to which they are bonded, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ１１ 、 R ｂ１１ 、 R ｃ１１ 、 and R ｄ１１ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～６ cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl, and said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～６ cycloalkyl, said phenyl, said 5- to 6-membered heteroaryl, and said 4- to 7-membered heterocycloalkyl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R １２ ; Alternatively, any R and R that are attached to the same N atom, together with the N atom to which they are attached, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; ｃ１１ and R ｄ１１ are, together with the N atom to which they are attached, a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; １２ form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; R ｈ１１ and R ｉ１１ are each independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ１１ and R ｉ１１ bonded to the same B atom, together with the B atom to which they are bonded, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ１２ 、 R ｂ１２ 、 R ｃ１２ 、 and R ｄ１２ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, and C １～６ haloalkyl, and said C １～６ alkyl, said C ２～６ alkenyl, and said C ２～６ alkynyl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ｇ ; R ｈ１２ and R ｉ１２ are each independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ１２ and R ｉ１２ together with the B atom to which they are attached form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ２０ 、 R ｂ２０ 、 R ｃ２０ 、 and R ｄ２０ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, and said 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ２１ ; or Alternatively, any R and R bonded to the same N atom together with the N atom to which they are bonded may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ｃ２０ and R ｄ２０ are, together with the N atom to which they are bonded, optionally substituted with 1, 2, 3, or 4 substituents independently selected from R to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; ２１ or may be substituted with 1, 2, 3, or 4 substituents independently selected from R to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group which may be substituted; Each R ｅ２０ is independently selected from H, CN, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C １～６ alkylthio, C １～６ alkylsulfonyl, C １～６ alkylcarbonyl, C １～６ alkylaminosulfonyl, carbamyl, C １～６ alkylcarbamyl, di(C １～６ alkyl)carbamyl, aminosulfonyl, C １～６ alkylaminosulfonyl, and di(C １～６ alkyl)aminosulfonyl; R ｈ２０ and R ｉ２０ each is independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ２０ and R ｉ２０ bonded to the same B atom, together with the B atom to which they are bonded, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ２１ 、R ｂ２１ 、R ｃ２１ 、and R ｄ２１ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～６ cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl, and the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～６ cycloalkyl, the phenyl, the 5- to 6-membered heteroaryl, and the 4- to 7-membered heterocycloalkyl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ｇ ; or Alternatively, any R and R bonded to the same N atom, together with the N atom to which they are bonded, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; ｃ２１ and R ｄ２１ are, together with the N atom to which they are bonded, optionally substituted with 1, 2, or 3 substituents independently selected from R to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; ｇ or may be substituted with 1, 2, or 3 substituents independently selected from R to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; R ｈ２１ and R ｉ２１ each independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ２１ and R ｉ２１ bonded to the same B atom together with the B atom to which they are bonded form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ２２ 、 R ｂ２２ 、 R ｃ２２ 、 and R ｄ２２ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, and said 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ２３ ; or Alternatively, any R and R bonded to the same N atom, together with the N atom to which they are bonded, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ｃ２２ and R ｄ２２ are, together with the N atom to which they are bonded, a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ２３ or may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; R ｈ２２ and R ｉ２２ each independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ２２ and R ｉ２２ bonded to the same B atom together with the B atom to which they are bonded form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ２３ 、 R ｂ２３ 、 R ｃ２３ 、 and R ｄ２３ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～６ cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl, and said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～６ cycloalkyl, said phenyl, said 5- to 6-membered heteroaryl, and said 4- to 7-membered heterocycloalkyl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ２４ ; Alternatively, any R and R bonded to the same N atom, together with the N atom to which they are bonded, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; ｃ２３ and R ｄ２３ are, together with the N atom to which they are bonded, optionally substituted with 1, 2, or 3 substituents independently selected from R ２４ to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group which may be substituted; R ｈ２３ and R ｉ２３ are each independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ２３ and R ｉ２３ bonded to the same B atom, together with the B atom to which they are bonded, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ２４ 、R ｂ２４ 、R ｃ２４ 、and R ｄ２４ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, and C １～６ haloalkyl, and the C １～６ alkyl, the C ２～６ alkenyl, and the C ２～６ alkynyl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ｇ ; R ｈ２４ and R ｉ２４ each independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ２４ and R ｉ２４ when attached to the same B atom, together with said B atom, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ３０ 、 R ｂ３０ 、 R ｃ３０ 、 and R ｄ３０ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, and said 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ３１ ; or Alternatively, any R and R that are attached to the same N atom, together with the N atom to which they are attached, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ｃ３０ and R ｄ３０ are, together with the N atom to which they are attached, a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ３１ are optionally substituted with 1, 2, 3, or 4 substituents independently selected from R to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R ｈ３０ and R ｉ３０ are each independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ３０ and R ｉ３０ bonded to the same B atom, together with said B atom to which they are bonded, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ３１ 、 R ｂ３１ 、 R ｃ３１ 、 and R ｄ３１ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～６ cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl, and said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～６ cycloalkyl, said phenyl, said 5- to 6-membered heteroaryl, and said 4- to 7-membered heterocycloalkyl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ３２ ; or Alternatively, any R and R attached to the same N atom, together with the N atom to which they are attached, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; ｃ３１ and R ｄ３１ are, together with the N atom to which they are attached, a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; ３２ are optionally substituted with 1, 2, or 3 substituents independently selected from R to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R ｈ３１ and R ｉ３１ each independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ３１ and R ｉ３１ bonded to the same B atom together with the B atom to which they are bonded form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ３２ 、R ｂ３２ 、R ｃ３２ 、and R ｄ３２ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, and C １～６ haloalkyl, and the C １～６ alkyl, the C ２～６ alkenyl, and the C ２～６ alkynyl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ｇ ; R ｈ３２ and R ｉ３２ each is independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ３２ and R ｉ３２ bonded to the same B atom, together with the B atom to which they are bonded, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ５０ 、 R ｂ５０ 、 R ｃ５０ 、 and R ｄ５０ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ５１ ; or Alternatively, any R and R that are attached to the same N atom, together with the N atom to which they are attached, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; ｃ５０ and R ｄ５０ are, together with the N atom to which they are attached, optionally substituted with 1, 2, or 3 substituents independently selected from R to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; ５１ and may be substituted with 1, 2, or 3 substituents independently selected from R to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group which may be substituted; R ｈ５０ and R ｉ５０ are each independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ５０ and R ｉ５０ bonded to the same B atom, together with said B atom to which they are bonded, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ５１ , R ｂ５１ , R ｃ５１ , and R ｄ５１ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～６ cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl, and the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～６ cycloalkyl, the phenyl, the 5- to 6-membered heteroaryl, and the 4- to 7-membered heterocycloalkyl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ５２ ; Alternatively, any R and R bonded to the same N atom, together with the N atom to which they are bonded, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ｃ５１ and R ｄ５１ are, together with the N atom to which they are bonded, a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ５２ are, together with the N atom to which they are bonded, a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; R ｈ５１ and R ｉ５１ are each independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ５１ and R ｉ５１ bonded to the same B atom, together with said B atom to which they are bonded, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ５２ 、 R ｂ５２ 、 R ｃ５２ 、 and R ｄ５２ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, and C １～６ haloalkyl, and the C １～６ alkyl, the C ２～６ alkenyl, and the C ２～６ alkynyl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ｇ ; R ｈ５２ and R ｉ５２ are each independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy; or any R ｈ５２ and R ｉ５２ bonded to the same B atom, together with said B atom to which they are bonded, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ６０ 、 R ｂ６０ 、 R ｃ６０ 、 and R ｄ６０ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, and said 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ６１ ; Alternatively, any R and R that are attached to the same N atom, together with the N atom to which they are attached, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ｃ６０ and R ｄ６０ are, together with the N atom to which they are attached, a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ６１ are optionally substituted with 1, 2, 3, or 4 substituents independently selected from R to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R ｈ６０ and R ｉ６０ are each independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ６０ and R ｉ６０ bonded to the same B atom, together with said B atom to which they are bonded, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ６１ 、 R ｂ６１ 、 R ｃ６１ 、 and R ｄ６１ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～６ cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl, and said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～６ cycloalkyl, said phenyl, said 5- to 6-membered heteroaryl, and said 4- to 7-membered heterocycloalkyl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ６２ ; Alternatively, any R and R attached to the same N atom, together with the N atom to which they are attached, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; ｃ６１ and R ｄ６１ are, together with the N atom to which they are attached, optionally substituted with 1, 2, or 3 substituents independently selected from R ６２ to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R ｈ６１ and R ｉ６１ each is independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ６１ and R ｉ６１ bonded to the same B atom, together with the B atom to which they are bonded, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ６２ 、 R ｂ６２ 、 R ｃ６２ 、 and R ｄ６２ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, and C １～６ haloalkyl, and said C １～６ alkyl, said C ２～６ alkenyl, and said C ２～６ alkynyl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ｇ ; Alternatively, any R and R that are attached to the same N atom, together with the N atom to which they are attached, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ｃ６２ and R ｄ６２ are, together with the N atom to which they are attached, a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ｇ are optionally substituted with 1, 2, 3, or 4 substituents independently selected from R to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R ｈ６２ and R ｉ６２ are each independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ６２ and R ｉ６２ bonded to the same B atom, together with the B atom to which they are bonded, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ７０ 、R ｂ７０ 、R ｃ７０ 、and R ｄ７０ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, and said 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ７１ ; or Alternatively, any R and R that are attached to the same N atom, together with the N atom to which they are attached, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group that is optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ｃ７０ and R ｄ７０ are, together with the N atom to which they are attached, a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ７１ may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; R ｈ７０ and R ｉ７０ are each independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ７０ and R ｉ７０ bonded to the same B atom, together with the B atom to which they are bonded, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ７１ 、R ｂ７１ 、R ｃ７１ 、and R ｄ７１ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～６ cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl, wherein said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～６ cycloalkyl, said phenyl, said 5- to 6-membered heteroaryl, and said 4- to 7-membered heterocycloalkyl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ７２ ; Alternatively, any R and R bonded to the same N atom, together with the N atom to which they are bonded, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; ｃ７１ and R ｄ７１ are, together with the N atom to which they are bonded, a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; ７２ form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; R ｈ７１ and R ｉ７１ are each independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ７１ and R ｉ７１ bonded to the same B atom, together with the B atom to which they are bonded, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ７２ 、R ｂ７２ 、R ｃ７２ 、and R ｄ７２ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, and C １～６ haloalkyl, and the C １～６ alkyl, the C ２～６ alkenyl, and the C ２～６ alkynyl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ｇ ; R ｈ７２ and R ｉ７２ each independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ７２ and R ｉ７２ together with the B atom to which they are attached form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; Each R ｇ is D, OH, NO ２ , CN, halo, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～６ cycloalkyl, C ３～６ cycloalkyl-C １～２ alkylene, C １～６ alkoxy, C １～６ haloalkoxy, C １～３ alkoxy-C １～３ alkyl, C １～３ alkoxy-C １～３ alkoxy, HO-C １～３ alkoxy, HO-C １～３ alkyl, cyano-C １～３ alkyl, H ２ N-C １～３ alkyl, amino, C １～６ alkylamino, di(C １～６ alkyl)amino, thio, C １～６ alkylthio, C １～６ alkylsulfinyl, C １～６ alkylsulfonyl, carbamyl, C １～６ alkylcarbamyl, di(C １～６ alkyl)carbamyl, carboxy, C １～６ alkylcarbonyl, C １～６ alkoxycarbonyl, C １～６ alkylcarbonylamino, C １～６ alkoxycarbonylamino, C １～６ alkylcarbonyloxy, aminocarbonyloxy, C １～６ alkylaminocarbonyloxy, di(C １～６ alkyl)aminocarbonyloxy, C １～６ alkylsulfonylamino, aminosulfonyl, C １～６ alkylaminosulfonyl, di(C １～６ alkyl)aminosulfonyl, aminosulfonylamino, C １～６ alkylaminosulfonylamino, di(C １～６ alkyl)aminosulfonylamino, aminocarbonylamino, C １～６ Selected independently from alkylaminocarbonylamino and di(C １～６ alkyl)aminocarbonylamino; provided that [Chemical Formula 6] When it is a double bond and Y is N, Cy １ is other than 3,5-dimethylisoxazol-4-yl).

2. each 【Chemical Formula 7】 represents, independently, a single bond or a double bond; X is N or CR ７ and; Y is N or C; R １ is H, D, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, halo, CN, OR ａ１ , SR ａ１ , C(O)R ｂ１ , C(O)NR ｃ１ R ｄ１ , C(O)OR ａ１ , OC(O)R ｂ１ , OC(O)NR ｃ１ R ｄ１ , NR ｃ１ R ｄ１ , NR ｃ１ C(O)R ｂ１ , NR ｃ１ , C(O)OR ａ１ , NR ｃ１ , C(O)NR ｃ１ R ｄ１ , NR ｃ１ , S(O)R ｂ１ , NR ｃ１ , S(O) ２ R ｂ１ , NR ｃ１ , S(O) ２ , NR ｃ１ R ｄ１ , S(O)R ｂ１ , S(O)NR ｃ１ R ｄ１ , S(O) ２ R ｂ１ , S(O) ２ , NR ｃ１ R ｄ１ , and BR ｈ１ R ｉ１ is selected from, and the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl are each, R ｇ optionally substituted with 1, 2, 3, or 4 substituents independently selected from; R ２ is H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, NO ２ , OR ａ２ , SR ａ２ , C(O)R ｂ２ , C(O)NR ｃ２ R ｄ２ , C(O)OR ａ２ , OC(O)R ｂ２ , OC(O)NR ｃ２ R ｄ２ , NR ｃ２ R ｄ２ , NR ｃ２ C(O)R ｂ２ , NR ｃ２ C(O)OR ａ２ , NR ｃ２ C(O)NR ｃ２ R ｄ２ , C(=NR ｅ２ ), R ｂ２ , C(=NOR ａ２ ), R ｂ２ , C(=NR ｅ２ , NR ｃ２ R ｄ２ , NR ｃ２ , C(=NR ｅ２ , NR ｃ２ R ｄ２ , NR ｃ２ , C(=NR ｅ２ ), R ｂ２ , NR ｃ２ , S(O)R ｂ２ , NR ｃ２ , S(O) ２ R ｂ２ , NR ｃ２ , S(O) ２ NR ｃ２ R ｄ２ 、 S(O)R ｂ２ 、 S(O)NR ｃ２ R ｄ２ 、 S(O) ２ R ｂ２ 、 S(O) ２ NR ｃ２ R ｄ２ 、 and BR ｈ２ R ｉ２ selected from, said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, 5- to 10-membered heteroaryl, said C ３～１０ cycloalkyl-C １～３ alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ alkylene, said C ６～１０ aryl-C １～３ alkylene, and said 5- to 10-membered heteroaryl-C １～３ alkylene may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ２２ ; Cy １ is selected from C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 6- to 10-membered heteroaryl, wherein the 4- to 10-membered heterocycloalkyl and the 6- to 10-membered heteroaryl each have at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S, the N and the S may be oxidized, and the ring-forming carbon atoms of the 6- to 10-membered heteroaryl and the 4- to 10-membered heterocycloalkyl may be substituted by oxo to form a carbonyl group, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, and the 6- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R １０ ; R ３ is H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-alkylene, C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-alkylene, C １～３ alkylene, halo, D, CN, NO ２ , OR ｆ３ , SR ａ３ , C(O)R ｂ３ , C(O)NR ｃ３ R ｄ３ , C(O)OR ａ３ , OC(O)R ｂ３ , OC(O)NR ｃ３ R ｄ３ , NR ｃ３ R ｊ３ , NR ｃ３ C(O)R ｂ３ , NR ｃ３ C(O)OR ａ３ , NR ｃ３ C(O)NR ｃ３ R ｄ３ , C(=NR ｅ３ )R ｂ３ , C(=NOR ａ３ )R ｂ３ , C(=NR ｅ３ )NR ｃ３ R ｄ３ , NR ｃ３ C(=NR ｅ３ )NR ｃ３ R ｄ３ , NR ｃ３ C(=NR ｅ３ )R ｂ３ , NR ｃ３ S(O)R ｂ３ , NR ｃ３ S(O) ２ R ｂ３ , NR ｃ３ S(O) ２ NR ｃ３ R ｄ３ 、 S(O)R ｂ３ 、 S(O)NR ｃ３ R ｄ３ 、 S(O) ２ R ｂ３ 、 S(O) ２ NR ｃ３ R ｄ３ 、 and BR ｈ３ R ｉ３ selected from, said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, said 5- to 10-membered heteroaryl, said C ３～１０ cycloalkyl-C １～３ alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ alkylene, said C ６～１０ aryl-C １～３ alkylene, and said 5- to 10-membered heteroaryl-C １～３ alkylene may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ３０ ; 【Chemical 8】 When it is a single bond and Y is C, YR ６ is selected from C=O and C=S; R ４ is H, D, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～６ cycloalkyl, 4- to 6-membered heterocycloalkyl, phenyl, 5- to 6-membered heteroaryl, halo, CN, OR ａ４ , SR ａ４ , C(O)R ｂ４ , C(O)NR ｃ４ R ｄ４ , C(O)OR ａ４ , OC(O)R ｂ４ , OC(O)NR ｃ４ R ｄ４ , NR ｃ４ R ｄ４ , NR ｃ４ C(O)R ｂ４ , NR ｃ４ C(O)OR ａ４ , NR ｃ４ C(O)NR ｃ４ R ｄ４ , NR ｃ４ , NR ｂ４ , NR ｃ４ , NR ２ R ｂ４ , NR ｃ４ , NR ２ , NR ｃ４ R ｄ４ , S(O)R ｂ４ , S(O)NR ｃ４ R ｄ４ , S(O) ２ R ｂ４ , S(O) ２ , NR ｃ４ R ｄ４ , and BR ｈ４ R ｉ４ is selected from; R ５ is H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, NO ２ , OR ａ５ , SR ａ５ , C(O)R ｂ５ , C(O)NR ｃ５ R ｄ５ , C(O)OR ａ５ , OC(O)R ｂ５ , OC(O)NR ｃ５ R ｄ５ , NR ｃ５ R ｄ５ , NR ｃ５ C(O)R ｂ５ , NR ｃ５ C(O)OR ａ５ , NR ｃ５ C(O)NR ｃ５ R ｄ５ , C(=NR ｅ５ ), R ｂ５ , C(=NOR ａ５ ), R ｂ５ , C(=NR ｅ５ ), NR ｃ５ R ｄ５ , NR ｃ５ C(=NR ｅ５ ), NR ｃ５ R ｄ５ , NR ｃ５ C(=NR ｅ５ ), R ｂ５ , NR ｃ５ , S(O)R ｂ５ , NR ｃ５ , S(O) ２ R ｂ５ , NR ｃ５ , S(O) ２ NR ｃ５ R ｄ５ 、 S(O)R ｂ５ 、 S(O)NR ｃ５ R ｄ５ 、 S(O) ２ R ｂ５ 、 S(O) ２ NR ｃ５ R ｄ５ 、 and BR ｈ５ R ｉ５ is selected from, the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, the 5- to 10-membered heteroaryl, the C ３～１０ cycloalkyl-C １～３ alkylene, the 4- to 10-membered heterocycloalkyl-C １～３ alkylene, the C ６～１０ aryl-C １～３ alkylene, and the 5- to 10-membered heteroaryl-C １～３ alkylene may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ５０ ; 【Chemical Formula 9】 is a double bond and when Y is N, R ４ and R ６ do not exist; 【Chemical 10】 is a double bond and Y is C, R ４ does not exist; R ６ is H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, NO ２ , OR ａ６ , SR ａ６ , C(O)R ｂ６ , C(O)NR ｃ６ R ｄ６ , C(O)OR ａ６ , OC(O)R ｂ６ , OC(O)NR ｃ６ R ｄ６ , NR ｃ６ R ｄ６ , NR ｃ６ C(O)R ｂ６ , NR ｃ６ C(O)OR ａ６ , NR ｃ６ C(O)NR ｃ６ R ｄ６ , C(=NR ｅ６ )R ｂ６ , C(=NOR ａ６ )R ｂ６ , C(=NR ｅ６ ), NR ｃ６ R ｄ６ , NR ｃ６ C(=NR ｅ６ ), NR ｃ６ R ｄ６ , NR ｃ６ C(=NR ｅ６ )R ｂ６ , NR ｃ６ , S(O)R ｂ６ , NR ｃ６ , S(O) ２ R ｂ６ , NR ｃ６ , S(O) ２ NR ｃ６ R ｄ６ 、 S(O)R ｂ６ 、 S(O)NR ｃ６ R ｄ６ 、 S(O) ２ R ｂ６ 、 S(O) ２ NR ｃ６ R ｄ６ 、 and BR ｈ６ R ｉ６ is selected from, and said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, said 5- to 10-membered heteroaryl, said C ３～１０ cycloalkyl-C １～３ alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ alkylene, said C ６～１０ aryl-C １～３ alkylene, and said 5- to 10-membered heteroaryl-C １～３ alkylene may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ６０ ; R ７ is H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, NO ２ , OR ａ７ , SR ａ７ , C(O)R ｂ７ , C(O)NR ｃ７ R ｄ７ , C(O)OR ａ７ , OC(O)R ｂ７ , OC(O)NR ｃ７ R ｄ７ , NR ｃ７ R ｄ７ , NR ｃ７ C(O)R ｂ７ , NR ｃ７ C(O)OR ａ７ , NR ｃ７ C(O)NR ｃ７ R ｄ７ , C(=NR ｅ７ ), R ｂ７ , C(=NOR ａ７ ), R ｂ７ , C(=NR ｅ７ ), NR ｃ７ R ｄ７ , NR ｃ７ C(=NR ｅ７ ), NR ｃ７ R ｄ７ , NR ｃ７ C(=NR ｅ７ ), R ｂ７ , NR ｃ７ , NR ｂ７ , NR ｃ７ , NR ２ R ｂ７ , NR ｃ７ , NR ２ NR ｃ７ R ｄ７ 、 S(O)R ｂ７ 、 S(O)NR ｃ７ R ｄ７ 、 S(O) ２ R ｂ７ 、 S(O) ２ NR ｃ７ R ｄ７ 、 and BR ｈ７ R ｉ７ selected from, said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, said 5- to 10-membered heteroaryl, said C ３～１０ cycloalkyl-C １～３ alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ alkylene, said C ６～１０ aryl-C １～３ alkylene, and said 5- to 10-membered heteroaryl-C １～３ alkylene may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ７０ ; Cy ２ is selected from C ３～１０ cycloalkyl, 4- to 14-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, wherein the 4- to 14-membered heterocycloalkyl and the 5- to 10-membered heteroaryl each have at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S, wherein the N and the S may be oxidized, and the ring-forming carbon atoms of the 5- to 10-membered heteroaryl and the 4- to 14-membered heterocycloalkyl may be substituted by oxo to form a carbonyl group, and the C ３～１０ cycloalkyl, the 4- to 14-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ２０ ; Each R １０ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, NO ２ , OR ａ１０ , SR ａ１０ , C(O)R ｂ１０ , C(O)NR ｃ１０ R ｄ１０ , C(O)OR ａ１０ , OC(O)R ｂ１０ , OC(O)NR ｃ１０ R ｄ１０ , NR ｃ１０ R ｄ１０ , NR ｃ１０ C(O)R ｂ１０ , NR ｃ１０ C(O)OR ａ１０ , NR ｃ１０ C(O)NR ｃ１０ R ｄ１０ , C(=NR ｅ１０ )R ｂ１０ , C(=NOR ａ１０ )R ｂ１０ , C(=NR ｅ１０ )NR ｃ１０ R ｄ１０ , NR ｃ１０ C(=NR ｅ１０ )NR ｃ１０ R ｄ１０ , NR ｃ１０ S(O)R ｂ１０ , NR ｃ１０ S(O) ２ R ｂ１０ , NR ｃ１０ S(O) ２ NR ｃ１０ R ｄ１０ , S(O)R ｂ１０ , SONR ｃ１０ R ｄ１０ , S(O) ２ R ｂ１０ , S(O) ２ NR ｃ１０ R ｄ１０ , and BR ｈ１０ R ｉ１０ is independently selected from, said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, said 5- to 10-membered heteroaryl, said C ３～１０ cycloalkyl-C １～３ alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ alkylene, said C ６～１０ aryl-C １～３ alkylene, and said 5- to 10-membered heteroaryl-C １～３ alkylene may each be substituted with 1, 2, 3, or 4 substituents independently selected from R １１ ; Each R １１ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, OR ａ１１ , SR ａ１１ , C(O)R ｂ１１ , C(O)NR ｃ１１ R ｄ１１ , C(O)OR ａ１１ , OC(O)R ｂ１１ , OC(O)NR ｃ１１ R ｄ１１ , NR ｃ１１ R ｄ１１ , NR ｃ１１ C(O)R ｂ１１ , NR ｃ１１ C(O)OR ａ１１ , NR ｃ１１ C(O)NR ｃ１１ R ｄ１１ , NR ｃ１１ , S(O)R ｂ１１ , NR ｃ１１ , S(O) ２ R ｂ１１ , NR ｃ１１ , S(O) ２ , NR ｃ１１ R ｄ１１ , S(O)R ｂ１１ , S(O)NR ｃ１１ R ｄ１１ , S(O) ２ R ｂ１１ , S(O) ２ , NR ｃ１１ R ｄ１１ , and BR ｈ１１ R ｉ１１ is independently selected from; Each R ２０ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, NO ２ , OR ａ２０ , SR ａ２０ , C(O)R ｂ２０ , C(O)NR ｃ２０ R ｄ２０ , C(O)OR ａ２０ , OC(O)R ｂ２０ , OC(O)NR ｃ２０ R ｄ２０ , NR ｃ２０ R ｄ２０ , NR ｃ２０ C(O)R ｂ２０ , NR ｃ２０ C(O)OR ａ２０ , NR ｃ２０ C(O)NR ｃ２０ R ｄ２０ , C(=NR ｅ２０ ), R ｂ２０ , C(=NOR ａ２０ ), R ｂ２０ , C(=NR ｅ２０ ), NR ｃ２０ R ｄ２０ , NR ｃ２０ C(=NR ｅ２０ ), NR ｃ２０ R ｄ２０ , NR ｃ２０ S(O)R ｂ２０ , NR ｃ２０ S(O) ２ R ｂ２０ , NR ｃ２０ S(O) ２ NR ｃ２０ R ｄ２０ , S(O)R ｂ２０ , SONR ｃ２０ R ｄ２０ , S(O) ２ R ｂ２０ , S(O) ２ NR ｃ２０ R ｄ２０ , and BR ｈ２０ R ｉ２０ is independently selected from, the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, the 5- to 10-membered heteroaryl, the C ３～１０ cycloalkyl-C １～３ alkylene, the 4- to 10-membered heterocycloalkyl-C １～３ alkylene, the C ６～１０ aryl-C １～３ alkylene, and the 5- to 10-membered heteroaryl-C １～３ alkylene may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ２１ ; Each R ２１ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, OR ａ２１ , SR ａ２１ , C(O)R ｂ２１ , C(O)NR ｃ２１ R ｄ２１ , C(O)OR ａ２１ , OC(O)R ｂ２１ , OC(O)NR ｃ２１ R ｄ２１ , NR ｃ２１ R ｄ２１ , NR ｃ２１ C(O)R ｂ２１ , NR ｃ２１ C(O)OR ａ２１ , NR ｃ２１ C(O)NR ｃ２１ R ｄ２１ , NR ｃ２１ , S(O)R ｂ２１ , NR ｃ２１ , S(O) ２ R ｂ２１ , NR ｃ２１ , S(O) ２ , NR ｃ２１ R ｄ２１ , S(O)R ｂ２１ , S(O)NR ｃ２１ R ｄ２１ , S(O) ２ R ｂ２１ , S(O) ２ , NR ｃ２１ R ｄ２１ , and BR ｈ２１ R ｉ２１ is independently selected from, said C １～６ alkyl, said C ２～６ Alkenyl, said C ２～６ Alkynyl, said C ３～１０ Cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ Aryl, said 5- to 10-membered heteroaryl, said C ３～１０ Cycloalkyl-C １～３ Alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ Alkylene, said C ６～１０ Aryl-C １～３ Alkylene, and said 5- to 10-membered heteroaryl-C １～３ Each of the alkylene is optionally substituted with 1, 2, 3, or 4 substituents independently selected from R ｇ ; and may be Each R ２２ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, NO ２ , OR ａ２２ , SR ａ２２ , C(O)R ｂ２２ , C(O)NR ｃ２２ R ｄ２２ , C(O)OR ａ２２ , OC(O)R ｂ２２ , OC(O)NR ｃ２２ R ｄ２２ , NR ｃ２２ R ｄ２２ , NR ｃ２２ C(O)R ｂ２２ , NR ｃ２２ C(O)OR ａ２２ , NR ｃ２２ C(O)NR ｃ２２ R ｄ２２ , NR ｃ２２ S(O)R ｂ２２ , NR ｃ２２ S(O) ２ R ｂ２２ , NR ｃ２２ S(O) ２ NR ｃ２２ R ｄ２２ , S(O)R ｂ２２ , S(O)NR ｃ２２ R ｄ２２ , S(O) ２ R ｂ２２ , S(O) ２ , NR ｃ２２ R ｄ２２ , and BR ｈ２２ R ｉ２２ is independently selected from, said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, said 5- to 10-membered heteroaryl, said C ３～１０ cycloalkyl-C １～３ alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ alkylene, said C ６～１０ aryl-C １～３ alkylene, and said 5- to 10-membered heteroaryl-C １～３ Each of the alkylene may be substituted with 1, 2, 3, or 4 substituents independently selected from R ２３ and may be; Each R ２３ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, OR ａ２３ , SR ａ２３ , C(O)R ｂ２３ , C(O)NR ｃ２３ R ｄ２３ , C(O)OR ａ２３ , OC(O)R ｂ２３ , OC(O)NR ｃ２３ R ｄ２３ , NR ｃ２３ R ｄ２３ , NR ｃ２３ C(O)R ｂ２３ , NR ｃ２３ C(O)OR ａ２３ , NR ｃ２３ C(O)NR ｃ２３ R ｄ２３ , NR ｃ２３ , NR ｂ２３ , NR ｃ２３ , NR ２ R ｂ２３ , NR ｃ２３ , NR ２ , NR ｃ２３ R ｄ２３ , NR ｂ２３ , NR ｃ２３ R ｄ２３ , NR ２ R ｂ２３ , NR ２ , NR ｃ２３ R ｄ２３ , and BR ｈ２３ R ｉ２３ is independently selected from; Each R ３０ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, NO ２ , OR ａ３０ , SR ａ３０ , C(O)R ｂ３０ , C(O)NR ｃ３０ R ｄ３０ , C(O)OR ａ３０ , OC(O)R ｂ３０ , OC(O)NR ｃ３０ R ｄ３０ , NR ｃ３０ R ｄ３０ , NR ｃ３０ C(O)R ｂ３０ , NR ｃ３０ C(O)OR ａ３０ , NR ｃ３０ C(O)NR ｃ３０ R ｄ３０ , NR ｃ３０ S(O)R ｂ３０ , NR ｃ３０ S(O) ２ R ｂ３０ , NR ｃ３０ S(O) ２ NR ｃ３０ R ｄ３０ , S(O)R ｂ３０ , S(O)NR ｃ３０ R ｄ３０ , S(O) ２ R ｂ３０ , S(O) ２ NR ｃ３０ R ｄ３０ , and BR ｈ３０ R ｉ３０ is independently selected from, said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, said 5- to 10-membered heteroaryl, said C ３～１０ cycloalkyl-C １～３ alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ alkylene, said C ６～１０ aryl-C １～３ alkylene, and said 5- to 10-membered heteroaryl-C １～３ Each of the alkylene is optionally substituted with 1, 2, 3, or 4 substituents independently selected from R ３１ and may be; Each R ３１ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, OR ａ３１ , SR ａ３１ , C(O)R ｂ３１ , C(O)NR ｃ３１ R ｄ３１ , C(O)OR ａ３１ , OC(O)R ｂ３１ , OC(O)NR ｃ３１ R ｄ３１ , NR ｃ３１ R ｄ３１ , NR ｃ３１ C(O)R ｂ３１ , NR ｃ３１ C(O)OR ａ３１ , NR ｃ３１ C(O)NR ｃ３１ R ｄ３１ , NR ｃ３１ , S(O)R ｂ３１ , NR ｃ３１ , S(O) ２ R ｂ３１ , NR ｃ３１ , S(O) ２ , NR ｃ３１ R ｄ３１ , S(O)R ｂ３１ , S(O)NR ｃ３１ R ｄ３１ , S(O) ２ R ｂ３１ , S(O) ２ , NR ｃ３１ R ｄ３１ , and BR ｈ３１ R ｉ３１ is independently selected from, said C １～６ alkyl, said C ２～６ Alkenyl, said C ２～６ Alkynyl, said C ３～１０ Cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ Aryl, said 5- to 10-membered heteroaryl, said C ３～１０ Cycloalkyl-C １～３ Alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ Alkylene, said C ６～１０ Aryl-C １～３ Alkylene, and said 5- to 10-membered heteroaryl-C １～３ Each of the alkylene may be substituted with 1, 2, 3, or 4 substituents independently selected from R ３２ and may be; Each R ３２ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～６ cycloalkyl, phenyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, halo, D, CN, OR ａ３２ , SR ａ３２ , C(O)R ｂ３２ , C(O)NR ｃ３２ R ｄ３２ , C(O)OR ａ３２ , OC(O)R ｂ３２ , OC(O)NR ｃ３２ R ｄ３２ , NR ｃ３２ R ｄ３２ , NR ｃ３２ , C(O)R ｂ３２ , NR ｃ３２ , C(O)OR ａ３２ , NR ｃ３２ , C(O)NR ｃ３２ R ｄ３２ , NR ｃ３２ , S(O)R ｂ３２ , NR ｃ３２ , S(O) ２ R ｂ３２ , NR ｃ３２ , S(O) ２ , NR ｃ３２ R ｄ３２ , S(O)R ｂ３２ , S(O)NR ｃ３２ R ｄ３２ , S(O) ２ R ｂ３２ , S(O) ２ , NR ｃ３２ R ｄ３２ , and BR ｈ３２ R ｉ３２ is independently selected from; Each R ５０ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, OR ａ５０ , SR ａ５０ , C(O)R ｂ５０ , C(O)NR ｃ５０ R ｄ５０ , C(O)OR ａ５０ , OC(O)R ｂ５０ , OC(O)NR ｃ５０ R ｄ５０ , NR ｃ５０ R ｄ５０ , NR ｃ５０ C(O)R ｂ５０ , NR ｃ５０ C(O)OR ａ５０ , NR ｃ５０ C(O)NR ｃ５０ R ｄ５０ , NR ｃ５０ S(O)R ｂ５０ , NR ｃ５０ S(O) ２ R ｂ５０ , NR ｃ５０ S(O) ２ NR ｃ５０ R ｄ５０ , S(O)R ｂ５０ , S(O)NR ｃ５０ R ｄ５０ , S(O) ２ R ｂ５０ , S(O) ２ NR ｃ５０ R ｄ５０ , and BR ｈ５０ R ｉ５０ is independently selected from, said C １～６ alkyl, said C ２～６ Alkenyl, said C ２～６ Alkynyl, said C ３～１０ Cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ Aryl, said 5- to 10-membered heteroaryl, said C ３～１０ Cycloalkyl-C １～３ Alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ Alkylene, said C ６～１０ Aryl-C １～３ Alkylene, and said 5- to 10-membered heteroaryl-C １～３ The alkylene may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ５１ and may be substituted; Each R ５１ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～６ cycloalkyl, C ６～１０ aryl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, halo, D, CN, OR ａ５１ , SR ａ５１ , C(O)R ｂ５１ , C(O)NR ｃ５１ R ｄ５１ , C(O)OR ａ５１ , OC(O)R ｂ５１ , OC(O)NR ｃ５１ R ｄ５１ , NR ｃ５１ R ｄ５１ , NR ｃ５１ , C(O)R ｂ５１ , NR ｃ５１ , C(O)OR ａ５１ , NR ｃ５１ , C(O)NR ｃ５１ R ｄ５１ , NR ｃ５１ , S(O)R ｂ５１ , NR ｃ５１ , S(O) ２ R ｂ５１ , NR ｃ５１ , S(O) ２ , NR ｃ５１ R ｄ５１ , S(O)R ｂ５１ , S(O)NR ｃ５１ R ｄ５１ , S(O) ２ R ｂ５１ , S(O) ２ , NR ｃ５１ R ｄ５１ , and BR ｈ５１ R ｉ５１ is independently selected from; Each R ６０ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, NO ２ , OR ａ６０ , SR ａ６０ , C(O)R ｂ６０ , C(O)NR ｃ６０ R ｄ６０ , C(O)OR ａ６０ , OC(O)R ｂ６０ , OC(O)NR ｃ６０ R ｄ６０ , NR ｃ６０ R ｄ６０ , NR ｃ６０ C(O)R ｂ６０ , NR ｃ６０ C(O)OR ａ６０ , NR ｃ６０ C(O)NR ｃ６０ R ｄ６０ , NR ｃ６０ S(O)R ｂ６０ , NR ｃ６０ S(O) ２ R ｂ６０ , NR ｃ６０ S(O) ２ NR ｃ６０ R ｄ６０ , S(O)R ｂ６０ , S(O)NR ｃ６０ R ｄ６０ , S(O) ２ R ｂ６０ , S(O) ２ , NR ｃ６０ R ｄ６０ , and BR ｈ６０ R ｉ６０ is independently selected from, said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, said 5- to 10-membered heteroaryl, said C ３～１０ cycloalkyl-C １～３ alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ alkylene, said C ６～１０ aryl-C １～３ alkylene, and said 5- to 10-membered heteroaryl-C １～３ Each alkylene may be substituted with 1, 2, 3, or 4 substituents independently selected from R ６１ and may be; Each R ６１ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, OR ａ６１ , SR ａ６１ , C(O)R ｂ６１ , C(O)NR ｃ６１ R ｄ６１ , C(O)OR ａ６１ , OC(O)R ｂ６１ , OC(O)NR ｃ６１ R ｄ６１ , NR ｃ６１ R ｄ６１ , NR ｃ６１ C(O)R ｂ６１ , NR ｃ６１ C(O)OR ａ６１ , NR ｃ６１ C(O)NR ｃ６１ R ｄ６１ , NR ｃ６１ , S(O)R ｂ６１ , NR ｃ６１ , S(O) ２ R ｂ６１ , NR ｃ６１ , S(O) ２ , NR ｃ６１ R ｄ６１ , S(O)R ｂ６１ , S(O)NR ｃ６１ R ｄ６１ , S(O) ２ R ｂ６１ , S(O) ２ , NR ｃ６１ R ｄ６１ , and BR ｈ６１ R ｉ６１ is independently selected from; Each R ７０ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, NO ２ , OR ａ７０ , SR ａ７０ , C(O)R ｂ７０ , C(O)NR ｃ７０ R ｄ７０ , C(O)OR ａ７０ , OC(O)R ｂ７０ , OC(O)NR ｃ７０ R ｄ７０ , NR ｃ７０ R ｄ７０ , NR ｃ７０ C(O)R ｂ７０ , NR ｃ７０ C(O)OR ａ７０ , NR ｃ７０ C(O)NR ｃ７０ R ｄ７０ , NR ｃ７０ S(O)R ｂ７０ , NR ｃ７０ S(O) ２ R ｂ７０ , NR ｃ７０ S(O) ２ NR ｃ７０ R ｄ７０ , S(O)R ｂ７０ , S(O)NR ｃ７０ R ｄ７０ , S(O) ２ R ｂ７０ , S(O) ２ , NR ｃ７０ R ｄ７０ , and BR ｈ７０ R ｉ７０ is independently selected from; R ａ１ 、 R ｂ１ 、 R ｃ１ 、 and R ｄ１ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ｇ ; Alternatively, any R and R that are attached to the same N atom, together with the N atom to which they are attached, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; ｃ１ and R ｄ１ such that they, together with the N atom to which they are attached, form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; ｇ which may be substituted with 1, 2, or 3 substituents independently selected from R to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R ｈ１ and R ｉ１ each is independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ１ and R ｉ１ bonded to the same B atom, together with the B atom to which they are bonded, is optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl to form a 5- or 6-membered heterocycloalkyl group; R ａ２ 、 R ｂ２ 、 R ｃ２ 、 and R ｄ２ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, and said 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ２２ ; or Alternatively, any R and R attached to the same N atom, together with the N atom to which they are attached, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ｃ２ and R ｄ２ are attached to the N atom to which they are attached, together with the N atom to which they are attached, and are optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ２２ form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; Each R ｅ２ is H, CN, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C １～６ alkylthio, C １～６ alkylsulfonyl, C １～６ alkylcarbonyl, C １～６ alkylaminosulfonyl, carbamyl, C １～６ alkylcarbamyl, di(C １～６ alkyl)carbamyl, aminosulfonyl, C １～６ alkylaminosulfonyl, and di(C １～６ alkyl)aminosulfonyl, and is independently selected from; R ｈ２ and R ｉ２ each is independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ２ and R ｉ２ bonded to the same B atom, together with the B atom to which they are bonded, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ３ 、 R ｂ３ 、 R ｃ３ 、 and R ｄ３ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ３０ ; Alternatively, any R and R bonded to the same N atom, together with the N atom to which they are bonded, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ｃ３ and R ｄ３ are, together with the N atom to which they are bonded, optionally substituted with 1, 2, 3, or 4 substituents independently selected from R to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; ３０ which may be substituted with 1, 2, 3, or 4 substituents independently selected from R to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; Each R ｅ３ is independently selected from H, CN, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C １～６ alkylthio, C １～６ alkylsulfonyl, C １～６ alkylcarbonyl, C １～６ alkylaminosulfonyl, carbamyl, C １～６ alkylcarbamyl, di(C １～６ alkyl)carbamyl, aminosulfonyl, C １～６ alkylaminosulfonyl, and di(C １～６ alkyl)aminosulfonyl; R ｆ３ and R ｊ３ are each independently selected from C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, and said 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ３０ ; or Alternatively, any R and R attached to the same N atom together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group which may be substituted with 1, 2, 3, or 4 substituents independently selected from R; ｃ３ and R ｊ３ are attached to the N atom to which they are attached together with the N atom to which they are attached, forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group which may be substituted with 1, 2, 3, or 4 substituents independently selected from R; ３０ from which 1, 2, 3, or 4 substituents may be substituted to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group which may be substituted with 1, 2, 3, or 4 substituents independently selected from R; R ｈ３ and R ｉ３ each is independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ３ and R ｉ３ bonded to the same B atom, together with said B atom to which they are bonded, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ４ 、 R ｂ４ 、 R ｃ４ 、 and R ｄ４ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, and said 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ｇ ; Alternatively, any R and R bonded to the same N atom, together with the N atom to which they are bonded, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; ｃ４ and R ｄ４ are, together with the N atom to which they are bonded, optionally substituted with 1, 2, or 3 substituents independently selected from R ｇ to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group which may be substituted; R ｈ４ and R ｉ４ are each independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ４ and R ｉ４ bonded to the same B atom, together with the B atom to which they are bonded, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ５ 、 R ｂ５ 、 R ｃ５ 、 and R ｄ５ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, and said 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ５０ ; or Alternatively, any R and R attached to the same N atom, together with the N atom to which they are attached, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ｃ５ and R ｄ５ such that they, together with the N atom to which they are attached, form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ５０ and R, together with the N atom to which they are attached, form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; Each R ｅ５ is H, CN, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C １～６ alkylthio, C １～６ alkylsulfonyl, C １～６ alkylcarbonyl, C １～６ alkylaminosulfonyl, carbamyl, C １～６ alkylcarbamyl, di(C １～６ alkyl)carbamyl, aminosulfonyl, C １～６ alkylaminosulfonyl, and di(C １～６ alkyl)aminosulfonyl, and is independently selected from; R ｈ５ and R ｉ５ each is independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ５ and R ｉ５ bonded to the same B atom, together with said B atom to which they are bonded, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ６ 、R ｂ６ 、R ｃ６ 、and R ｄ６ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ６０ ; Alternatively, any R and R that are attached to the same N atom, together with the N atom to which they are attached, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group that is optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ｃ６ and R ｄ６ such that they, together with the N atom to which they are attached, form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group that is optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ６０ and is optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; Each R ｅ６ is independently selected from H, CN, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C １～６ alkylthio, C １～６ alkylsulfonyl, C １～６ alkylcarbonyl, C １～６ alkylaminosulfonyl, carbamyl, C １～６ alkylcarbamyl, di(C １～６ alkyl)carbamyl, aminosulfonyl, C １～６ alkylaminosulfonyl, and di(C １～６ alkyl)aminosulfonyl; R ｈ６ and R ｉ６ each independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R and R bonded to the same B atom ｈ６ and R ｉ６ together with the B atom to which they are attached form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ７ 、 R ｂ７ 、 R ｃ７ 、 and R ｄ７ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ７０ ; or Alternatively, any R and R attached to the same N atom together with the N atom to which they are attached may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ｃ７ and R ｄ７ are attached to the N atom to which they are attached together with the N atom to which they are attached to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ７０ from which they are attached together with the N atom to which they are attached to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; Each R ｅ７ is H, CN, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C １～６ alkylthio, C １～６ alkylsulfonyl, C １～６ alkylcarbonyl, C １～６ alkylaminosulfonyl, carbamyl, C １～６ alkylcarbamyl, di(C １～６ alkyl)carbamyl, aminosulfonyl, C １～６ alkylaminosulfonyl, and di(C １～６ alkyl)aminosulfonyl, independently selected from; R ｈ７ and R ｉ７ each is independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R and R ｈ７ bonded to the same B atom, together with the B atom to which they are bonded, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C ｉ７ alkyl and C １～６ haloalkyl; １～６ ​ R ａ１０ 、 R ｂ１０ 、 R ｃ１０ 、 and R ｄ１０ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R １１ ; or Alternatively, any R and R that are attached to the same N atom, together with the N atom to which they are attached, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ｃ１０ and R ｄ１０ such that, together with the N atom to which they are attached, form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; １１ wherein said 4-, 5-, 6-, or 7-membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; Each R ｅ１０ is H, CN, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C １～６ alkylthio, C １～６ alkylsulfonyl, C １～６ alkylcarbonyl, C １～６ alkylaminosulfonyl, carbamyl, C １～６ alkylcarbamyl, di(C １～６ alkyl)carbamyl, aminosulfonyl, C １～６ alkylaminosulfonyl, and di(C １～６ alkyl)aminosulfonyl, independently selected from; R ｈ１０ and R ｉ１０ each is independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ１０ and R ｉ１０ bonded to the same B atom, together with the B atom to which they are bonded, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ１１ 、R ｂ１１ 、R ｃ１１ 、and R ｄ１１ is each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～６ cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; Alternatively, any R bonded to the same N atom ｃ１１ and R ｄ１１ together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R ｈ１１ and R ｉ１１ each independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R and R bonded to the same B atom together with the B atom to which they are bonded are 1, 2, 3, or 4 substituents independently selected from C alkyl and C haloalkyl may form a 5- or 6-membered heterocycloalkyl group optionally substituted with; ｈ１１ and R ｉ１１ are, together with the B atom to which they are attached, a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C alkyl and C haloalkyl; １～６ alkyl and C １～６ haloalkyl may form a 5- or 6-membered heterocycloalkyl group optionally substituted with; R ａ２０ 、 R ｂ２０ 、 R ｃ２０ 、 and R ｄ２０ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ２１ ; or Alternatively, any R and R that are attached to the same N atom together with the N atom to which they are attached may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ｃ２０ and R ｄ２０ such that they, together with the N atom to which they are attached, form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ２１ wherein the 4-, 5-, 6-, or 7-membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; Each R ｅ２０ is independently selected from H, CN, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C １～６ alkylthio, C １～６ alkylsulfonyl, C １～６ alkylcarbonyl, C １～６ alkylaminosulfonyl, carbamyl, C １～６ alkylcarbamyl, di(C １～６ alkyl)carbamyl, aminosulfonyl, C １～６ alkylaminosulfonyl, and di(C １～６ alkyl)aminosulfonyl; R ｈ２０ and R ｉ２０ each is independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R and R bonded to the same B atom together with the B atom to which they are bonded form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C ｈ２０ alkyl and C ｉ２０ haloalkyl; １～６ alkyl and C １～６ haloalkyl; R ａ２１ 、 R ｂ２１ 、 R ｃ２１ 、 and R ｄ２１ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～６ cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl, and said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～６ cycloalkyl, said phenyl, said 5- to 6-membered heteroaryl, and said 4- to 7-membered heterocycloalkyl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ｇ ; or Alternatively, any R and R bonded to the same N atom together with the N atom to which they are bonded may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; ｃ２１ and R ｄ２１ such that they, together with the N atom to which they are bonded, form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; ｇ and form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; R ｈ２１ and R ｉ２１ each is independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ２１ and R ｉ２１ bonded to the same B atom together with the B atom to which they are bonded form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ２２ 、 R ｂ２２ 、 R ｃ２２ 、 and R ｄ２２ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, and said 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ２３ ; or Alternatively, any R and R that are attached to the same N atom, together with the N atom to which they are attached, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ｃ２２ and R ｄ２２ such that they, together with the N atom to which they are attached, form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ２３ or may be substituted with 1, 2, 3, or 4 substituents independently selected from R to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R ｈ２２ and R ｉ２２ each is independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ２２ and R ｉ２２ bonded to the same B atom together with the B atom to which they are bonded form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ２３ , R ｂ２３ , R ｃ２３ , and R ｄ２３ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～６ cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; Alternatively, any R bonded to the same N atom ｃ２３ and R ｄ２３ together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R ｈ２３ and R ｉ２３ each is independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R and R ｈ２３ bonded to the same B atom together with the B atom to which they are bonded form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C ｉ２３ alkyl and C １～６ haloalkyl; １～６ ​ R ａ３０ 、 R ｂ３０ 、 R ｃ３０ 、 and R ｄ３０ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ３１ ; or Alternatively, any R and R that are attached to the same N atom, together with the N atom to which they are attached, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group that is optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ｃ３０ and R ｄ３０ such that they, together with the N atom to which they are attached, form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group that is optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ３１ and R such that they, together with the N atom to which they are attached, form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group that is optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; R ｈ３０ and R ｉ３０ each is independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R and R bonded to the same B atom together with the B atom to which they are bonded form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C ｈ３０ alkyl and C ｉ３０ haloalkyl; １～６ alkyl and C １～６ haloalkyl; R ａ３１ 、 R ｂ３１ 、 R ｃ３１ 、 and R ｄ３１ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～６ cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl, and said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～６ cycloalkyl, said phenyl, said 5- to 6-membered heteroaryl, and said 4- to 7-membered heterocycloalkyl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ３２ ; Alternatively, any R and R bonded to the same N atom, together with the N atom to which they are bonded, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; ｃ３１ and R ｄ３１ such that, together with the N atom to which they are attached, form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; ３２ which may be substituted with 1, 2, or 3 substituents independently selected from R to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R ｈ３１ and R ｉ３１ each independently is selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ３１ and R ｉ３１ bonded to the same B atom, together with the B atom to which they are bonded, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ３２ , R ｂ３２ , R ｃ３２ , and R ｄ３２ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, and C １～６ haloalkyl; R ｈ３２ and R ｉ３２ each is independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ３２ and R ｉ３２ bonded to the same B atom together with the B atom to which they are bonded form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ５０ 、 R ｂ５０ 、 R ｃ５０ 、 and R ｄ５０ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ５１ ; or Alternatively, any R and R that are attached to the same N atom, together with the N atom to which they are attached, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group that is optionally substituted with 1, 2, or 3 substituents independently selected from R; ｃ５０ and R ｄ５０ such that, together with the N atom to which they are attached, they form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group that is optionally substituted with 1, 2, or 3 substituents independently selected from R; ５１ which is optionally substituted with 1, 2, or 3 substituents independently selected from R to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R ｈ５０ and R ｉ５０ each is independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ５０ and R ｉ５０ bonded to the same B atom together with the B atom to which they are bonded form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ５１ , R ｂ５１ , R ｃ５１ , and R ｄ５１ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～６ cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; Alternatively, any R bonded to the same N atom ｃ５１ and R ｄ５１ together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R ｈ５１ and R ｉ５１ each is independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ５１ and R ｉ５１ bonded to the same B atom, together with the B atom to which they are bonded, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ６０ 、 R ｂ６０ 、 R ｃ６０ 、 and R ｄ６０ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, and said 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ６１ ; Alternatively, any R and R bonded to the same N atom, together with the N atom to which they are bonded, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ｃ６０ and R ｄ６０ are, together with the N atom to which they are bonded, optionally substituted with 1, 2, 3, or 4 substituents independently selected from R to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; ６１ or may be substituted with 1, 2, 3, or 4 substituents independently selected from R to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group which may be substituted; R ｈ６０ and R ｉ６０ each is independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ６０ and R ｉ６０ bonded to the same B atom together with the B atom to which they are bonded form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ６１ , R ｂ６１ , R ｃ６１ , and R ｄ６１ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～６ cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; Alternatively, any R bonded to the same N atom ｃ６１ and R ｄ６１ together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R ｈ６１ and R ｉ６１ each is independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ６１ and R ｉ６１ bonded to the same B atom together with the B atom to which they are bonded form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; R ａ７０ 、 R ｂ７０ 、 R ｃ７０ 、 and R ｄ７０ is each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl; or Alternatively, any R bonded to the same N atom ｃ７０ and R ｄ７０ together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R ｈ７０ and R ｉ７０ each is independently selected from OH, C １～６ alkoxy, and C １～６ haloalkoxy, or any R ｈ７０ and R ｉ７０ bonded to the same B atom together with the B atom to which they are bonded form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C １～６ alkyl and C １～６ haloalkyl; Each R ｇ is D, OH, NO ２ , CN, halo, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～６ cycloalkyl, C ３～６ cycloalkyl-C １～２ alkylene, C １～６ alkoxy, C １～６ haloalkoxy, C １～３ alkoxy-C １～３ alkyl, C １～３ alkoxy-C １～３ alkoxy, HO-C １～３ alkoxy, HO-C １～３ alkyl, cyano-C １～３ alkyl, H ２ N-C １～３ alkyl, amino, C １～６ alkylamino, di(C １～６ alkyl)amino, thio, C １～６ alkylthio, C １～６ alkylsulfinyl, C １～６ alkylsulfonyl, carbamyl, C １～６ alkylcarbamyl, di(C １～６ alkyl)carbamyl, carboxy, C １～６ alkylcarbonyl, C １～６ alkoxycarbonyl, C １～６ alkylcarbonylamino, C １～６ alkoxycarbonylamino, C １～６ alkylcarbonyloxy, aminocarbonyloxy, C １～６ alkylaminocarbonyloxy, di(C １～６ alkyl)aminocarbonyloxy, C １～６ alkylsulfonylamino, aminosulfonyl, C １～６ alkylaminosulfonyl, di(C １～６ alkyl)aminosulfonyl, aminosulfonylamino, C １～６ alkylaminosulfonylamino, di(C １～６ alkyl)aminosulfonylamino, aminocarbonylamino, C １～６ Alkylaminocarbonylamino, and di(C １～６ alkyl)aminocarbonylamino, the compound according to claim 1, or a pharmaceutically acceptable salt thereof.

3. The compound of formula I is a compound of formula Ia: 【Chemical 11】 or a pharmaceutically acceptable salt thereof (wherein, Y is N or C; R １ is selected from H, D, C １～６ alkyl, C １～６ haloalkyl, halo, and CN; R ２ is H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl- C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, OR ａ２ , SR ａ２ , C(O)R ｂ２ , C(O)NR ｃ２ R ｄ２ , C(O)OR ａ２ , OC(O)R ｂ２ , OC(O)NR ｃ２ R ｄ２ , NR ｃ２ R ｄ２ , NR ｃ２ C(O)R ｂ２ , NR ｃ２ C(O)OR ａ２ , NR ｃ２ C(O)NR ｃ２ R ｄ２ , NR ｃ２ , S(O) ２ R ｂ２ , NR ｃ２ , S(O) ２ , NR ｃ２ R ｄ２ , S(O) ２ R ｂ２ , and S(O) ２ , NR ｃ２ R ｄ２ selected from, said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, said 5- to 10-membered heteroaryl, said C ３～１０ Cycloalkyl-C １～３ alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ alkylene, said C ６～１０ aryl-C １～３ alkylene, and said 5- to 10-membered heteroaryl-C １～３ The alkylene groups may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ２２ and may be substituted; Cy １ is selected from C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 6- to 10-membered heteroaryl, wherein the 4- to 10-membered heterocycloalkyl and the 6- to 10-membered heteroaryl each have at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S, the N and the S may be oxidized, and the ring-forming carbon atoms of the 6- to 10-membered heteroaryl and the 4- to 10-membered heterocycloalkyl may be substituted by oxo to form a carbonyl group, and the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and the 6- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R １０ ; and may be substituted with 1, 2, 3, or 4 substituents independently selected from; R ３ is H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-alkylene, C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-alkylene, C １～３ alkylene, halo, D, CN, OR ｆ３ , SR ａ３ , C(O)R ｂ３ , C(O)NR ｃ３ R ｄ３ , C(O)OR ａ３ , OC(O)R ｂ３ , OC(O)NR ｃ３ R ｄ３ , NR ｃ３ R ｊ３ , NR ｃ３ C(O)R ｂ３ , NR ｃ３ C(O)OR ａ３ , NR ｃ３ C(O)NR ｃ３ R ｄ３ , NR ｃ３ , S(O) ２ R ｂ３ , NR ｃ３ , S(O) ２ , NR ｃ３ R ｄ３ , S(O) ２ R ｂ３ , and S(O) ２ , NR ｃ３ R ｄ３ selected from, said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, said 5- to 10-membered heteroaryl, said C ３～１０ Cycloalkyl-C １～３ alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ alkylene, said C ６～１０ aryl-C １～３ alkylene, and said 5- to 10-membered heteroaryl-C １～３ Each of the alkylene is optionally substituted with 1, 2, 3, or 4 substituents independently selected from R ３０ and may be substituted; R ５ is H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl- C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, OR ａ５ , SR ａ５ , C(O)R ｂ５ , C(O)NR ｃ５ R ｄ５ , C(O)OR ａ５ , OC(O)R ｂ５ , OC(O)NR ｃ５ R ｄ５ , NR ｃ５ R ｄ５ , NR ｃ５ C(O)R ｂ５ , NR ｃ５ C(O)OR ａ５ , NR ｃ５ C(O)NR ｃ５ R ｄ５ , NR ｃ５ , S(O) ２ R ｂ５ , NR ｃ５ , S(O) ２ , NR ｃ５ R ｄ５ , S(O) ２ R ｂ５ , and S(O) ２ , NR ｃ５ R ｄ５ selected from, said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, said 5- to 10-membered heteroaryl, said C ３～１０ Cycloalkyl-C １～３ alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ alkylene, said C ６～１０ aryl-C １～３ alkylene, and said 5- to 10-membered heteroaryl-C １～３ Each of the alkylene is optionally substituted with 1, 2, 3, or 4 substituents independently selected from R ５０ and may be; 【Chemical Formula 12】 is a double bond and Y is N, then R ４ and R ６ do not exist; 【Chemical 13】 When it is a double bond and Y is C, R ４ does not exist; R ６ is H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, OR ａ６ , SR ａ６ , C(O)R ｂ６ , C(O)NR ｃ６ R ｄ６ , C(O)OR ａ６ , OC(O)R ｂ６ , OC(O)NR ｃ６ R ｄ６ , NR ｃ６ R ｄ６ , NR ｃ６ C(O)R ｂ６ , NR ｃ６ C(O)OR ａ６ , NR ｃ６ C(O)NR ｃ６ R ｄ６ , NR ｃ６ , S(O) ２ R ｂ６ , NR ｃ６ , S(O) ２ , NR ｃ６ R ｄ６ , S(O) ２ R ｂ６ , and S(O) ２ , NR ｃ６ R ｄ６ selected from, said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, said 5- to 10-membered heteroaryl, said C ３～１０ Cycloalkyl-C １～３ alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ alkylene, said C ６～１０ aryl-C １～３ alkylene, and said 5- to 10-membered heteroaryl-C １～３ The alkylene groups may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ６０ and may be substituted; R ７ is H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-alkylene, C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-alkylene, C １～３ alkylene, halo, D, CN, OR ａ７ , SR ａ７ , C(O)R ｂ７ , C(O)NR ｃ７ R ｄ７ , C(O)OR ａ７ , OC(O)R ｂ７ , OC(O)NR ｃ７ R ｄ７ , NR ｃ７ R ｄ７ , NR ｃ７ , NR ｂ７ , NR ｃ７ , C(O)OR ａ７ , NR ｃ７ , C(O)NR ｃ７ R ｄ７ , NR ｃ７ , NR ２ R ｂ７ , NR ｃ７ , NR ２ , NR ｃ７ R ｄ７ , S(O) ２ R ｂ７ , and S(O) ２ , NR ｃ７ R ｄ７ selected from; Cy ２ is selected from C ３～１０ cycloalkyl, 4- to 14-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, wherein the 4- to 14-membered heterocycloalkyl and the 5- to 10-membered heteroaryl each have at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S, wherein the N and the S may be oxidized, and the ring-forming carbon atoms of the 5- to 10-membered heteroaryl and the 4- to 14-membered heterocycloalkyl may be substituted by oxo to form a carbonyl group, and the C ３～１０ cycloalkyl, the 4- to 14-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ２０ ; Each R １０ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, OR ａ１０ , SR ａ１０ , C(O)R ｂ１０ , C(O)NR ｃ１０ R ｄ１０ , C(O)OR ａ１０ , OC(O)R ｂ１０ , OC(O)NR ｃ１０ R ｄ１０ , NR ｃ１０ R ｄ１０ , NR ｃ１０ C(O)R ｂ１０ , NR ｃ１０ C(O)OR ａ１０ , NR ｃ１０ C(O)NR ｃ１０ R ｄ１０ , NR ｃ１０ , NR ２ S(O) ｂ１０ , NR ｃ１０ , NR ２ S(O) ｃ１０ NR ｄ１０ , S(O) ２ R ｂ１０ , and S(O) ２ , NR ｃ１０ R ｄ１０ is independently selected from; Each R ２０ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, OR ａ２０ , SR ａ２０ , C(O)R ｂ２０ , C(O)NR ｃ２０ R ｄ２０ , C(O)OR ａ２０ , OC(O)R ｂ２０ , OC(O)NR ｃ２０ R ｄ２０ , NR ｃ２０ R ｄ２０ , NR ｃ２０ C(O)R ｂ２０ , NR ｃ２０ C(O)OR ａ２０ , NR ｃ２０ C(O)NR ｃ２０ R ｄ２０ , NR ｃ２０ , NR ２ R ｂ２０ , NR ｃ２０ , NR ２ , NR ｃ２０ R ｄ２０ , NR ２ R ｂ２０ , and NR ２ , NR ｃ２０ R ｄ２０ is independently selected from, the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, the 5- to 10-membered heteroaryl, the C ３～１０ Cycloalkyl-C １～３ alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ alkylene, said C ６～１０ aryl-C １～３ alkylene, and said 5- to 10-membered heteroaryl-C １～３ The alkylene groups may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ２１ and may be substituted; Each R ２１ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, OR ａ２１ , SR ａ２１ , C(O)R ｂ２１ , C(O)NR ｃ２１ R ｄ２１ , C(O)OR ａ２１ , OC(O)R ｂ２１ , OC(O)NR ｃ２１ R ｄ２１ , NR ｃ２１ R ｄ２１ , NR ｃ２１ C(O)R ｂ２１ , NR ｃ２１ C(O)OR ａ２１ , NR ｃ２１ C(O)NR ｃ２１ R ｄ２１ , NR ｃ２１ , NR ２ S(O) ｂ２１ , NR ｃ２１ , NR ２ S(O) ｃ２１ NR ｄ２１ , S(O) ２ R ｂ２１ , and S(O) ２ , NR ｃ２１ R ｄ２１ is independently selected from; Each R ２２ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, OR ａ２２ , SR ａ２２ , C(O)R ｂ２２ , C(O)NR ｃ２２ R ｄ２２ , C(O)OR ａ２２ , OC(O)R ｂ２２ , OC(O)NR ｃ２２ R ｄ２２ , NR ｃ２２ R ｄ２２ , NR ｃ２２ , NR ｂ２２ , NR ｃ２２ , NR ａ２２ , NR ｃ２２ , NR ｃ２２ R ｄ２２ , NR ｃ２２ , NR ２ R ｂ２２ , NR ｃ２２ , NR ２ , NR ｃ２２ R ｄ２２ , S(O) ２ R ｂ２２ , and S(O) ２ , NR ｃ２２ R ｄ２２ is independently selected from; Each R ３０ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, OR ａ３０ , SR ａ３０ , C(O)R ｂ３０ , C(O)NR ｃ３０ R ｄ３０ , C(O)OR ａ３０ , OC(O)R ｂ３０ , OC(O)NR ｃ３０ R ｄ３０ , NR ｃ３０ R ｄ３０ , NR ｃ３０ C(O)R ｂ３０ , NR ｃ３０ C(O)OR ａ３０ , NR ｃ３０ C(O)NR ｃ３０ R ｄ３０ , NR ｃ３０ , S(O) ２ R ｂ３０ , NR ｃ３０ , S(O) ２ , NR ｃ３０ R ｄ３０ , S(O) ２ R ｂ３０ , and S(O) ２ , NR ｃ３０ R ｄ３０ is independently selected from, the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, the 5- to 10-membered heteroaryl, the C ３～１０ Cycloalkyl-C １～３ alkylene, said 4- to 10-membered heterocycloalkyl-C １～３ alkylene, said C ６～１０ aryl-C １～３ alkylene, and said 5- to 10-membered heteroaryl-C １～３ The alkylene groups may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ３１ and may be substituted; Each R ３１ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, OR ａ３１ , SR ａ３１ , C(O)R ｂ３１ , C(O)NR ｃ３１ R ｄ３１ , C(O)OR ａ３１ , OC(O)R ｂ３１ , OC(O)NR ｃ３１ R ｄ３１ , NR ｃ３１ R ｄ３１ , NR ｃ３１ , NR ｂ３１ , NR ｃ３１ , NR ａ３１ , NR ｃ３１ , NR ｃ３１ R ｄ３１ , NR ｃ３１ , NR ２ R ｂ３１ , NR ｃ３１ , NR ２ , NR ｃ３１ R ｄ３１ , S(O) ２ R ｂ３１ , and S(O) ２ , NR ｃ３１ R ｄ３１ is independently selected from; Each R ５０ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, OR ａ５０ , SR ａ５０ , C(O)R ｂ５０ , C(O)NR ｃ５０ R ｄ５０ , C(O)OR ａ５０ , OC(O)R ｂ５０ , OC(O)NR ｃ５０ R ｄ５０ , NR ｃ５０ R ｄ５０ , NR ｃ５０ C(O)R ｂ５０ , NR ｃ５０ C(O)OR ａ５０ , NR ｃ５０ C(O)NR ｃ５０ R ｄ５０ , NR ｃ５０ , NR ２ R ｂ５０ , NR ｃ５０ , NR ２ NR ｃ５０ R ｄ５０ , S(O) ２ R ｂ５０ , and S(O) ２ , NR ｃ５０ R ｄ５０ is independently selected from; Each R ６０ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, C ３～１０ cycloalkyl-C １～３ alkylene, 4- to 10-membered heterocycloalkyl-C １～３ alkylene, C ６～１０ aryl-C １～３ alkylene, 5- to 10-membered heteroaryl-C １～３ alkylene, halo, D, CN, OR ａ６０ , SR ａ６０ , C(O)R ｂ６０ , C(O)NR ｃ６０ R ｄ６０ , C(O)OR ａ６０ , OC(O)R ｂ６０ , OC(O)NR ｃ６０ R ｄ６０ , NR ｃ６０ R ｄ６０ , NR ｃ６０ , NR ｂ６０ , NR ｃ６０ , NR ａ６０ , NR ｃ６０ , NR ｃ６０ R ｄ６０ , NR ｃ６０ , NR ２ R ｂ６０ , NR ｃ６０ , NR ２ , NR ｃ６０ R ｄ６０ , and NR ２ R ｂ６０ , and NR ２ , NR ｃ６０ R ｄ６０ is independently selected from; R ａ２ 、 R ｂ２ 、 R ｃ２ 、 and R ｄ２ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ２２ ; or Alternatively, any R and R that are attached to the same N atom, together with the N atom to which they are attached, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ｃ２ and R ｄ２ are, together with the N atom to which they are attached, a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ２２ are optionally substituted with 1, 2, 3, or 4 substituents independently selected from R to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R ａ３ 、 R ｂ３ 、 R ｃ３ 、 and R ｄ３ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, and said 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ３０ ; or Alternatively, any R and R that are attached to the same N atom, together with the N atom to which they are attached, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ｃ３ and R ｄ３ are, together with the N atom to which they are attached, a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ３０ may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; R ｆ３ and R ｊ３ are each independently selected from C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, and said 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ３０ ; or Alternatively, any R and R bonded to the same N atom together with the N atom to which they are bonded may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ｃ３ and R ｊ３ are, together with the N atom to which they are bonded, a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ３０ and may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; R ａ５ 、 R ｂ５ 、 R ｃ５ 、 and R ｄ５ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, and said 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ５０ ; or Alternatively, any R and R bonded to the same N atom, together with the N atom to which they are bonded, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ｃ５ and R ｄ５ are, together with the N atom to which they are bonded, a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ５０ and may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; R ａ６ 、 R ｂ６ 、 R ｃ６ 、 and R ｄ６ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ６０ ; or Alternatively, any R and R bonded to the same N atom together with the N atom to which they are bonded may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ｃ６ and R ｄ６ are, together with the N atom to which they are bonded, a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ６０ form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; R ａ７ 、 R ｂ７ 、 R ｃ７ 、 and R ｄ７ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl; Alternatively, any R bonded to the same N atom ｃ７ and R ｄ７ together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R ａ１０ 、 R ｂ１０ 、 R ｃ１０ 、 and R ｄ１０ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl; or Alternatively, any R bonded to the same N atom ｃ１０ and R ｄ１０ together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R ａ２０ 、 R ｂ２０ 、 R ｃ２０ 、 and R ｄ２０ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, and said 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ２１ ; or Alternatively, any R and R bonded to the same N atom, together with the N atom to which they are bonded, may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ｃ２０ and R ｄ２０ are, together with the N atom to which they are bonded, optionally substituted with 1, 2, 3, or 4 substituents independently selected from R ２１ to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R ａ２１ , R ｂ２１ , R ｃ２１ , and R ｄ２１ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～６ cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; Alternatively, any R bonded to the same N atom ｃ２１ and R ｄ２１ together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R ａ２２ 、 R ｂ２２ 、 R ｃ２２ 、 and R ｄ２２ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl; or Alternatively, any R bonded to the same N atom ｃ２２ and R ｄ２２ together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R ａ３０ 、 R ｂ３０ 、 R ｃ３０ 、 and R ｄ３０ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, and said 5- to 10-membered heteroaryl may each be substituted with 1, 2, 3, or 4 substituents independently selected from R ３１ ; or Alternatively, any R and R bonded to the same N atom together with the N atom to which they are bonded may form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R; ｃ３０ and R ｄ３０ are, together with the N atom to which they are bonded, optionally substituted with 1, 2, 3, or 4 substituents independently selected from R to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; ３１ and may be substituted with 1, 2, 3, or 4 substituents independently selected from R to form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group which may be substituted; R ａ３１ , R ｂ３１ , R ｃ３１ , and R ｄ３１ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～６ cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; Alternatively, any R bonded to the same N atom ｃ３１ and R ｄ３１ together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R ａ５０ 、R ｂ５０ 、R ｃ５０ 、and R ｄ５０ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl; or Alternatively, any R bonded to the same N atom ｃ５０ and R ｄ５０ together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group; R ａ６０ 、 R ｂ６０ 、 R ｃ６０ 、 and R ｄ６０ is each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl; or Alternatively, any R and R attached to the same N atom, together with the N atom to which they are attached, form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group), the compound according to claim 1 or 2. ｃ６０ and R ｄ６０ is, the compound according to claim 1 or 2.

4. Y is N or C; R １ is selected from H, D, and C １～６ alkyl; R ２ is H, C １～６ alkyl, C １～６ haloalkyl, halo, D, CN, OR ａ２ , and NR ｃ２ R ｄ２ is selected from, and said C １～６ alkyl may be substituted with one or two substituents independently selected from R ２２ ; Cy １ is selected from C ６～１０ aryl and 6- to 10-membered heteroaryl, said 6- to 10-membered heteroaryl having at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S, and the ring-forming carbon atoms of the 6- to 10-membered heteroaryl may be substituted by oxo to form a carbonyl group, and said C ６～１０ aryl and said 6- to 10-membered heteroaryl may each be substituted with 1, 2, or 3 substituents independently selected from R １０ ; R ３ is H, C １～６ alkyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, halo, D, CN, OR ｆ３ , and NR ｃ３ R ｊ３ is selected from; wherein said C １～６ alkyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, and said 5- to 10-membered heteroaryl may each be substituted with 1, 2, or 3 substituents independently selected from R ３０ ; and may be substituted with; R ５ is H, C １～６ alkyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, halo, D, CN, OR ａ５ , C(O)NR ｃ５ R ｄ５ , and NR ｃ５ R ｄ５ is selected from, and the C １～６ alkyl, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl may each be substituted with 1, 2, or 3 substituents independently selected from R ５０ ; and may be substituted; 【Chemical Formula 14】 is a double bond and when Y is N, R ４ and R ６ do not exist; 【Chemical Formula 15】 When it is a double bond and Y is C, R ４ does not exist; R ６ is H, C １～６ alkyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, halo, D, CN, OR ａ６ , and NR ｃ６ R ｄ６ is selected from; the C １～６ alkyl, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl may each be substituted with 1, 2, or 3 substituents independently selected from R ６０ ; and R ７ is selected from H, C １～６ alkyl, C １～６ haloalkyl, halo, D, and CN; Cy ２ is selected from 4- to 10-membered heterocycloalkyl, said 4- to 10-membered heterocycloalkyl having at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S, the ring-forming carbon atoms of said 4- to 10-membered heterocycloalkyl may be substituted by oxo to form a carbonyl group, said 4- to 10-membered heterocycloalkyl is optionally substituted with 1, 2, or 3 substituents independently selected from R ２０ ; Each R １０ is selected independently from C １～６ alkyl, C １～６ haloalkyl, halo, D, CN, OR ａ１０ , and NR ｃ１０ R ｄ１０ ; Each R ２０ is C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, C １～６ haloalkyl, halo, D, CN, OR ａ２０ , C(O)R ｂ２０ , C(O)NR ｃ２０ R ｄ２０ , and NR ｃ２０ R ｄ２０ is independently selected from; the C １～６ alkyl, the C ２～６ alkenyl, and the C ２～６ alkynyl may each be substituted with 1, 2, or 3 substituents independently selected from R ２１ ; Each R ２１ is C １～６ alkyl, C １～６ haloalkyl, halo, D, CN, OR ａ２１ , and NR ｃ２１ R ｄ２１ is independently selected from; Each R ２２ is selected from C １～６ alkyl, C １～６ haloalkyl, halo, D, CN, OR ａ２２ , and NR ｃ２２ R ｄ２２ independently; Each R ３０ is C １～６ alkyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, halo, D, CN, OR ａ３０ , C(O)NR ｃ３０ R ｄ３０ , and NR ｃ３０ R ｄ３０ is independently selected from, and the C １～６ alkyl, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl may each be substituted with 1, 2, or 3 substituents independently selected from R ３１ ; Each R ３１ is selected independently from C １～６ alkyl, C １～６ haloalkyl, halo, D, CN, OR ａ３１ , and NR ｃ３１ R ｄ３１ ; Each R ５０ is C １～６ alkyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, halo, D, CN, OR ａ５０ , and NR ｃ５０ R ｄ５０ is independently selected from; Each R ６０ is C １～６ alkyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, halo, D, CN, OR ａ６０ , C(O)NR ｃ６０ R ｄ６０ , C(O)OR ａ６０ , and NR ｃ６０ R ｄ６０ is independently selected from; R ａ２ 、 R ｃ２ 、 and R ｄ２ are each independently selected from H, C １～６ alkyl, and C １～６ haloalkyl, and said C １～６ alkyl may be substituted with one or two substituents independently selected from R ２２ ; Each R ｃ３ is independently selected from H, C １～６ alkyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and the C １～６ alkyl, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl may each be substituted with 1, 2, or 3 substituents independently selected from R ３０ ; R ｆ３ and R ｊ３ are each independently selected from C １～６ alkyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and the C １～６ alkyl, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl may each be substituted with 1, 2, or 3 substituents independently selected from R ３０ ; or Alternatively, any R and R that are attached to the same N atom, together with the N atom to which they are attached, may form a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; ｃ３ and R ｊ３ such that they, together with the N atom to which they are attached, form a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; ３０ and may be substituted with 1, 2, or 3 substituents independently selected from R to form a 4-, 5-, or 6-membered heterocycloalkyl group; R ａ５ 、 R ｃ５ 、 and R ｄ５ are each independently selected from H, C １～６ alkyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and said C １～６ alkyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, and said 5- to 10-membered heteroaryl may each be substituted with 1, 2, or 3 substituents independently selected from R ５０ ; Alternatively, any R and R bonded to the same N atom, together with the N atom to which they are bonded, may form a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; ｃ５ and R ｄ５ are, together with the N atom to which they are bonded, a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; ５０ form a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; R ａ６ 、 R ｃ６ 、 and R ｄ６ are each independently selected from H, C １～６ alkyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and said C １～６ alkyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, and said 5- to 10-membered heteroaryl may each be substituted with 1, 2, or 3 substituents independently selected from R ６０ ; Alternatively, any R and R attached to the same N atom, together with the N atom to which they are attached, may form a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; ｃ６ and R ｄ６ are attached to the N atom to which they are attached, together with the N atom to which they are attached, R ６０ from which 1, 2, or 3 substituents independently selected may form a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted; R ａ１０ 、 R ｃ１０ 、 and R ｄ１０ are each independently selected from H, C １～６ alkyl, and C １～６ haloalkyl; R ａ２０ 、 R ｂ２０ 、 R ｃ２０ 、 and R ｄ２０ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, and C １～６ haloalkyl, and the C １～６ alkyl, the C ２～６ alkenyl, and the C ２～６ alkynyl may each be substituted with 1, 2, or 3 substituents independently selected from R ２１ ; R ａ２１ , R ｃ２１ , and R ｄ２１ are each independently selected from H, C １～６ alkyl, and C １～６ haloalkyl; R ａ２２ 、R ｃ２２ 、and R ｄ２２ are each independently selected from H, C １～６ alkyl, and C １～６ haloalkyl; R ａ３０ 、 R ｃ３０ 、 and R ｄ３０ are each independently selected from H, C １～６ alkyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and the C １～６ alkyl, the C ２～６ alkenyl, the C ２～６ alkynyl, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl may each be substituted with 1, 2, or 3 substituents independently selected from R ３１ ; or Alternatively, any R and R that are attached to the same N atom together with the N atom to which they are attached may form a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; ｃ３０ and R ｄ３０ such that together with the N atom to which they are attached, they form a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; ３１ wherein the 4-, 5-, or 6-membered heterocycloalkyl group is optionally substituted with 1, 2, or 3 substituents independently selected from R; R ａ３１ 、 R ｃ３１ 、 and R ｄ３１ are each independently selected from H, C １～６ alkyl, and C １～６ haloalkyl; R ａ５０ 、 R ｃ５０ 、 and R ｄ５０ are each independently selected from H, C １～６ alkyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl; Alternatively, any R bonded to the same N atom ｃ５０ and R ｄ５０ together with the N atom to which they are attached form a 4-, 5-, or 6-membered heterocycloalkyl group; R ａ６０ 、 R ｃ６０ 、 and R ｄ６０ are each independently selected from H, C １～６ alkyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl; Alternatively, any R bonded to the same N atom ｃ６０ and R ｄ６０ 4. The compound of claim 3, wherein, together with the N atom to which they are attached, form a 4-, 5-, or 6-membered heterocycloalkyl group, or a pharma- ceutically acceptable salt thereof.

5. Y is N or C; R １ is H; R ２ is selected from H, C １～６ alkyl, C １～６ haloalkyl, halo, D, and CN; Cy １ is selected from C ６～１０ aryl and 6- to 10-membered heteroaryl, wherein the 6- to 10-membered heteroaryl has at least one ring-forming carbon atom and one or two ring-forming heteroatoms independently selected from N and O, and the C ６～１０ aryl and the 6- to 10-membered heteroaryl may each be substituted with 1, 2, or 3 substituents independently selected from R １０ ; R ３ is H, C １～６ alkyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, halo, D, CN, OR ｆ３ , and NR ｃ３ R ｊ３ selected from, said C １～６ alkyl, said C ３～１０ cycloalkyl, and said 4- to 10-membered heterocycloalkyl may each be substituted with 1, 2, or 3 substituents independently selected from R ３０ ; R ５ is selected from H, C １～６ alkyl, C １～６ haloalkyl, halo, D, and CN; 【Chemical 16】 is a double bond and when Y is N, R ６ does not exist; R ６ is selected from H, C １～６ alkyl, C １～６ haloalkyl, halo, D, and CN; R ７ is selected from H, C １～６ alkyl, C １～６ haloalkyl, halo, D, and CN; Cy ２ is selected from 4- to 6-membered heterocycloalkyl, said 4- to 6-membered heterocycloalkyl having at least one ring-forming carbon atom and one or two ring-forming heteroatoms independently selected from N and O, said 4- to 6-membered heterocycloalkyl being optionally substituted with 1, 2, or 3 substituents independently selected from R ２０ ; Each R １０ is selected independently from C １～６ alkyl, C １～６ haloalkyl, halo, D, CN, OR ａ１０ , and NR ｃ１０ R ｄ１０ ; and is selected independently from Each R ２０ is C １～６ alkyl, C １～６ haloalkyl, halo, D, CN, OR ａ２０ , C(O)R ｂ２０ , C(O)NR ｃ２０ R ｄ２０ , and NR ｃ２０ R ｄ２０ independently selected from, said C １～６ alkyl may be substituted with one or two substituents independently selected from R ２１ ; Each R ２１ is C １～６ alkyl, C １～６ haloalkyl, halo, D, CN, OR ａ２１ , and NR ｃ２１ R ｄ２１ is independently selected from; Each R ３０ is C １～６ alkyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, halo, D, CN, OR ａ３０ , C(O)NR ｃ３０ R ｄ３０ , and NR ｃ３０ R ｄ３０ is independently selected from; wherein said C １～６ alkyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, and said 5- to 10-membered heteroaryl may each be substituted with 1, 2, or 3 substituents independently selected from R ３１ ; Each R ３１ is C １～６ alkyl, C １～６ haloalkyl, halo, D, CN, OR ａ３１ , and NR ｃ３１ R ｄ３１ is independently selected from; Each R ｃ３ is independently selected from H, C １～６ alkyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and the C １～６ alkyl, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl may each be substituted with 1, 2, or 3 substituents independently selected from R ３０ ; R ｆ３ and R ｊ３ each independently represents C １～６ alkyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and the C １～６ alkyl, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl may each be substituted with 1, 2, or 3 substituents independently selected from R ３０ ; or Alternatively, any R and R that are attached to the same N atom, together with the N atom to which they are attached, may form a 4-, 5-, or 6-membered heterocycloalkyl group that is optionally substituted with 1, 2, or 3 substituents independently selected from R; ｃ３ and R ｊ３ such that they, together with the N atom to which they are attached, form a 4-, 5-, or 6-membered heterocycloalkyl group that is optionally substituted with 1, 2, or 3 substituents independently selected from R; ３０ optionally substituted with 1, 2, or 3 substituents independently selected from R; R ａ１０ 、 R ｃ１０ 、 and R ｄ１０ are each independently selected from H, C １～６ alkyl, and C １～６ haloalkyl; R ａ２０ 、R ｂ２０ 、R ｃ２０ 、and R ｄ２０ are each independently selected from H, C １～６ alkyl, C ２～６ alkenyl, C ２～６ alkynyl, and C １～６ haloalkyl, and the C １～６ alkyl, the C ２～６ alkenyl, and the C ２～６ alkynyl may each be substituted with 1, 2, or 3 substituents independently selected from R ２１ ; R ａ２１ , R ｃ２１ , and R ｄ２１ are each independently selected from H, C １～６ alkyl, and C １～６ haloalkyl; R ａ３０ 、 R ｃ３０ 、 and R ｄ３０ are each independently selected from H, C １～６ alkyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and 5- to 10-membered heteroaryl, and said C １～６ alkyl, said C ２～６ alkenyl, said C ２～６ alkynyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, and said 5- to 10-membered heteroaryl may each be substituted with 1, 2, or 3 substituents independently selected from R ３１ ; or Alternatively, any R and R attached to the same N atom, together with the N atom to which they are attached, may form a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; ｃ３０ and R ｄ３０ are attached to the N atom to which they are attached, together with the N atom to which they are attached, to form a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from R; ３１ is optionally substituted with 1, 2, or 3 substituents independently selected from R to form a 4-, 5-, or 6-membered heterocycloalkyl group; R ａ３１ 、 R ｃ３１ 、 and R ｄ３１ are each independently selected from H, C １～６ alkyl, and C １～６ haloalkyl, a compound according to any one of claims 1 to 4, or a pharmaceutically acceptable salt thereof.

6. The compound of formula I is a compound of formula II: 【Chemical 17】 or a pharmaceutically acceptable salt thereof, the compound according to claim 1.

7. X is CR ７ and; R １ is selected from H; R ２ is selected from H, C １～３ haloalkyl, and halo; Cy １ is C １０ aryl, and the C １０ aryl may be substituted with one or two substituents independently selected from R １０ ; and may be substituted with one or two substituents independently selected from R R ３ is selected from H and 4- to 6-membered heterocycloalkyl, and the 4- to 6-membered heterocycloalkyl may be substituted with one or two substituents independently selected from ３０ R; R ５ is H; 【Chemical Formula 18】 is a double bond, Y is N, and R ４ and R ６ are absent; R ７ is selected from H or halo; Cy ２ is a 4- to 6-membered heterocycloalkyl having at least one ring-forming carbon atom and one or two ring-forming heteroatoms independently selected from N and O, and the 4- to 6-membered heterocycloalkyl may be substituted with one or two substituents independently selected from R ２０ ; and may be substituted with one or two substituents independently selected from Each R １０ is independently selected from ａ１０ OR; Each R ２０ is independently selected from C(O)R ｂ２０ ; and Each R ３０ is independently selected from NR ｃ３０ R ｄ３０ ; and is selected independently therefrom Each R ａ１０ is independently selected from H and C １～３ alkyl; Each R ｂ２０ is C １～３ alkyl or C ２～４ alkenyl; R ｃ３０ and R ｄ３０ each independently selected from C １～３ alkyl, the compound according to any one of claims 1 to 3.

8. The compound of formula I is a compound of formula III: 【Chemical Formula 19】 or a pharmaceutically acceptable salt thereof, the compound according to claim 1.

9. The compound of formula I is a compound of formula IV: 【Chemical 20】 or a pharmaceutically acceptable salt thereof, the compound according to claim 1.

10. The compound of formula I is a compound of formula V: 【Chemical 21】 or a pharmaceutically acceptable salt thereof, the compound according to claim 1.

11. The compound of formula I is a compound of formula VI: 【Chemical 22】 or a pharmaceutically acceptable salt thereof, the compound according to any one of claims 1 to 4.

12. The compound of formula I is a compound of formula VII: 【Chemical 23】 or a pharmaceutically acceptable salt thereof, the compound according to claim 1 or 2.

13. wherein X is CR ７ The compound according to claim 1, wherein X is CR.

14. The compound according to claim 1, wherein X is N.

15. 【Chemical Formula 24】 is a double bond, Y is N, and R ４ and R ６ is absent, the compound according to any one of claims 1, 13, and 14.

16. 【Fig. 25】 is a double bond, Y is C, and R ４ The compound according to any one of claims 1, 13, and 14, wherein ４ does not exist.

17. R １ wherein R is H, D, C １～６ alkyl, C １～６ haloalkyl, halo, OR ａ１ , and NR ｃ１ R ｄ１ and is selected from the group consisting of, a compound according to any one of claims 1, 2, and 6 to 16.

18. R １ The compound according to any one of claims 1 to 17, wherein R is H.

19. R ２ is selected from H, C １～６ alkyl, C １～６ haloalkyl, halo, D, and CN, wherein said C １～６ alkyl may be substituted with one or two substituents independently selected from R ２２ The compound according to any one of claims 1, 2, and 6 to 18, which may be substituted with 1 or 2 substituents independently selected from.

20. Each R ２２ is independently selected from C １～６ alkyl, C １～６ haloalkyl, halo, and CN, and the compound according to any one of claims 1, 2, and 6 to 19.

21. R ２ The compound according to any one of claims 1 to 20, wherein R is halo.

22. Cy １ is selected from C ６～１０ aryl and 6- to 10-membered heteroaryl, each of the 6- to 10-membered heteroaryls having at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S, the N and the S may be oxidized, and the ring-forming carbon atoms of the 6- to 10-membered heteroaryl may be substituted by oxo to form a carbonyl group, and the C ６～１０ aryl and the 6- to 10-membered heteroaryl are each optionally substituted with 1 or 2 substituents independently selected from R １０ , a compound according to any one of claims 1 to 21.

23. Cy １ is C １０ optionally substituted with one or two substituents independently selected from R ６～１０ aryl, a compound according to any one of claims 1 to 22.

24. Cy １ is a 6- to 10-membered heteroaryl optionally substituted with one or two substituents independently selected from R １０ The compound according to any one of claims 1 to 22

25. R １０ is C １～３ alkyl, C １～３ haloalkyl, halo, D, CN, and OR ａ１０ The compound according to any one of claims 1 to 22, selected from

26. R ３ is selected from H, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, and OR ｆ３ wherein the 4- to 10-membered heterocycloalkyl and the C ６～１０ aryl may each be substituted with one or two substituents independently selected from R ３０ The compound according to any one of claims 1 to 4 and 6 to 25.

27. R ３ is selected from H, 4- to 6-membered heterocycloalkyl, and OR ｆ３ and the 4- to 6-membered heterocycloalkyl may be substituted with one or two substituents independently selected from R ３０ The compound according to any one of claims 1 to 26, which may be substituted with one or two substituents independently selected from R

28. Each R ３０ is independently selected from C １～６ alkyl, C １～６ haloalkyl, 4- to 6-membered heterocycloalkyl, 5- to 6-membered heteroaryl, halo, D, CN, OR ａ３０ , and NR ｃ３０ R ｄ３０ ; and the C １～６ alkyl, the 4- to 6-membered heterocycloalkyl, and the 5- to 6-membered heteroaryl may each be substituted with one or two substituents independently selected from R ３１ ; a compound according to any one of claims 1 to 27.

29. Each R ３１ is C １～６ alkyl, C １～６ haloalkyl, halo, D, and CN, and is independently selected from the group consisting of the compounds according to any one of claims 1 to 28.

30. R ５ is H, C １～６ alkyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, halo, D, CN, OR ａ５ , C(O)NR ｃ５ R ｄ５ , and NR ｃ５ R ｄ５ selected from, said C １～６ alkyl, said C ３～１０ cycloalkyl, said 4- to 10-membered heterocycloalkyl, said C ６～１０ aryl, and said 5- to 10-membered heteroaryl may each be substituted with 1, 2, or 3 substituents independently selected from R ５０ The compound according to any one of claims 1 to 29.

31. R ５ The compound according to any one of claims 1 to 30, wherein R is H.

32. Each R ５０ is C １～６ alkyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, halo, D, CN, OR ａ５０ , and NR ｃ５０ R ｄ５０ and is independently selected from, a compound according to any one of claims 1 to 31.

33. R ６ is H, C １～６ alkyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, halo, D, CN, OR ａ６ , and NR ｃ６ R ｄ６ is selected from, and the C １～６ alkyl, the C ３～１０ cycloalkyl, the 4- to 10-membered heterocycloalkyl, the C ６～１０ aryl, and the 5- to 10-membered heteroaryl may each be substituted with 1, 2, or 3 substituents independently selected from R ６０ The compound according to any one of claims 1 to 32.

34. Each R ６０ is C １～６ alkyl, C １～６ haloalkyl, C ３～１０ cycloalkyl, 4- to 10-membered heterocycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, halo, D, CN, OR ａ６０ , C(O)NR ｃ６０ R ｄ６０ , C(O)OR ａ６０ , and NR ｃ６０ R ｄ６０ and is independently selected from, a compound according to any one of claims 1 to 33.

35. R ７ wherein R is selected from H, C １～３ alkyl, C １～３ haloalkyl, and halo, and the compound according to any one of claims 1 to 34.

36. R ７ The compound according to any one of claims 1 to 35, wherein R is halo.

37. Cy ２ is a 4- to 6-membered heterocycloalkyl having at least one ring-forming carbon atom and one or two ring-forming heteroatoms independently selected from N and O, and the 4- to 6-membered heterocycloalkyl is optionally substituted with one or two substituents independently selected from R ２０ The compound according to any one of claims 1 to 36, which may be substituted with one or two substituents independently selected from

38. Cy ２ is 【Table 1】 (wherein n is 0, 1, or 2) The compound according to any one of claims 1 to 37, selected from

39. Cy ２ where Cy ２ is -a1, the compound according to claim 38.

40. Cy ２ where Cy ２ is - e, the compound according to claim 38.

41. Each R ２０ is independently selected from C １～６ alkyl, C １～６ haloalkyl, halo, D, CN, and C(O)R ｂ２０ wherein said C １～６ alkyl may be substituted with one or two substituents independently selected from R ２１ The compound according to any one of claims 1 to 40.

42. Each R ２１ is C １～６ alkyl, C １～６ haloalkyl, halo, D, CN, OR ａ２１ , and NR ｃ２１ R ｄ２１ and is independently selected from the group consisting of, a compound according to any one of claims 1 to 41.

43. The compound of formula I is 1-(4-(8-chloro-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-1H-pyrazolo[4,3-c]-quinolin-1-yl)-piperidin-1-yl)prop-2-en-1-one, or 1-(4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-1-yl)prop-2-en-1-one, or a pharmaceutically acceptable salt thereof, a compound according to any one of claims 1 to 7.

44. The compound of formula I is 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4,4-difluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4,4-difluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-inoyl)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-Acryloyl-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(5-fluoroquinolin-8-yl)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(isoquinolin-4-yl)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-Acryloyl-4-(8-chloro-7-(2-chloro-3-methylphenyl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(2-chloro-3-methylphenyl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-Acryloyl-4-(8-chloro-7-(2,3-dichlorophenyl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(But-2-enoyl)-4-(8-chloro-7-(2,3-dichlorophenyl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-methyl-2-(trifluoromethyl)phenyl)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-Acryloyl-4-(8-chloro-6-fluoro-7-(3-methyl-2-(trifluoromethyl)phenyl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; Methyl 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-8-(2-cyanoethyl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-2-yl)propanoate; 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-8-(2-cyanoethyl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-2-yl)-N,N-dimethylpropanamide; 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-2-propyl-1H-pyrrolo[3,2-c]quinolin-8-yl)propanenitrile; 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-2-(1-methyl-1H-pyrazol-4-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propanenitrile; 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propanenitrile; 3-(1-(2-Azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-3-phenyl-1H-pyrrolo[3,2-c]quinolin-8-yl)propanenitrile; 3-(1-(2-Azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-3-(pyridin-3-yl)-1H-pyrrolo[3,2-c]quinolin-8-yl)propanenitrile; 3-(1-(2-Azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-3-(2-methyloxazol-5-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propanenitrile; 3-(1-(2-Azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-3-(2-methylthiazol-5-yl)-1H-pyrrolo[3,2-c]quinolin-8-yl)propanenitrile; and 3-(1-(2-Azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-3-(1-methyl-1H-pyrazol-4-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propanenitrile; The compound according to any one of claims 1 to 7, selected from 3-(1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-3-phenyl-1H-pyrrolo[3,2-c]quinolin-8-yl)propanenitrile; or a pharmaceutically acceptable salt thereof.

45. The compound of formula I is 3-(1-(2-Azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-2-(1-methyl-1H-pyrazol-3-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propanenitrile; 3-(2-Benzyl-1-(2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propanenitrile; 3-(1-(2-Azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-3-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]quinolin-8-yl)propanenitrile; 3-(1-(2-Azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-3-(6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrrolo[3,2-c]quinolin-8-yl)propanenitrile; 3-(1-(2-Azabicyclo[2.1.1]hexan-5-yl)-3-chloro-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propanenitrile; 1-(2-Azabicyclo[2.1.1]hexan-5-yl)-8-(2-cyanoethyl)-6-fluoro-N-(2-hydroxyethyl)-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinoline-3-carboxamide; N-Benzyl-1-(2-azabicyclo[2.1.1]hexan-5-yl)-8-(2-cyanoethyl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinoline-3-carboxamide; 3-(1-(2-Azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-3-(hydroxymethyl)-7-(3-hydroxynaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propanenitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 3-(1-((1R,4R,5S)-2-azabicyclo[2.1.1]hexan-5-yl)-8-(2-cyanoethyl)-4-ethoxy-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-1H-pyrrolo[3,2-c]quinolin-2-yl)-N,N-dimethylpropanamide; Methyl 3-(1-((1R,4R,5S)-2-azabicyclo[2.1.1]hexan-5-yl)-8-(2-cyanoethyl)-3-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-methoxy-1H-pyrrolo[3,2-c]quinolin-2-yl)propanoate; 3-(2-(3-(azetidin-1-yl)-3-oxopropyl)-1-((1R,4R,5S)-2-azabicyclo[2.1.1]hexan-5-yl)-6-fluoro-7-(7-fluoronaphthalen-1-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-8-yl)propanenitrile; 8-(1-((2S,4S)-2-(cyanomethyl)-1-((E)-4-fluorobut-2-enoyl)piperidin-4-yl)-6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthonitrile; 8-(1-((2S,4S)-2-(cyanomethyl)-1-(2-fluoroacryloyl)piperidin-4-yl)-6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthonitrile; 8-(1-((2S,4S)-1-(but-2-inoyl)-2-(cyanomethyl)piperidin-4-yl)-6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthonitrile; 8-(1-(((2S,4S)-2-(cyanomethyl)-1-((E)-4-methoxybut-2-enoyl)piperidin-4-yl)-6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthonitrile; 8-(1-(((2S,4S)-2-(cyanomethyl)-1-((E)-4-fluorobut-2-enoyl)piperidin-4-yl)-6-fluoro-8-methyl-4-((S)-1-(((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthonitrile; 8-(1-(((2S,4S)-2-(cyanomethyl)-1-(2-fluoroacryloyl)piperidin-4-yl)-6-fluoro-8-methyl-4-((S)-1-(((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthonitrile; 8-(1-(((2S,4S)-2-(cyanomethyl)-1-((E)-4-methoxybut-2-enoyl)piperidin-4-yl)-6-fluoro-8-methyl-4-((S)-1-(((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthonitrile; 8-(1-(((2S,4S)-2-(cyanomethyl)-1-((E)-4-fluorobut-2-enoyl)piperidin-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthonitrile; 8-(1-(((2S,4S)-2-(cyanomethyl)-1-(2-fluoroacryloyl)piperidin-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthonitrile; 8-(1-(((2S,4S)-1-(but-2-inoyl)-2-(cyanomethyl)piperidin-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthonitrile; 8-(1-(((2S,4S)-2-(cyanomethyl)-1-((E)-4-methoxybut-2-enoyl)piperidin-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthonitrile; 8-(1-(((2S,4S)-2-(cyanomethyl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-pyrazolo[4,3-c]quinolin-7-yl)-1-naphthonitrile; 2-(((2S,4S)-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-(((2S,4S)-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-(((2S,4S)-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-(((2S,4S)-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-8-methyl-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-8-methyl-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-inoyl)-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-8-methyl-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-8-methyl-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-8-methyl-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-inoyl)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-6-fluoro-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-6-fluoro-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-enoyl)-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-6-fluoro-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-6-fluoro-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-6-fluoro-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; and 2-((2S,4S)-1-(but-2-enoyl)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; A compound according to any one of claims 1 to 7, selected from 2-((2S,4S)-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-6-fluoro-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-6-fluoro-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-enoyl)-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-6-fluoro-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-6-fluoro-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-6-fluoro-4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)-1H-pyrazolo[4,3-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; and 2-((2S,4S)-1-(but-2-enoyl)-4-(8-chloro-7-(5,6-dimethyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-pyrrolo[3,2-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; or a pharmaceutically acceptable salt thereof.

46. A pharmaceutical composition comprising a compound according to any one of claims 1 to 45 or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier or excipient.

47. A method for inhibiting KRAS activity in an in vitro system, comprising contacting a compound according to any one of claims 1 to 45 or the composition according to claim 46 with KRAS in vitro.

48. A medicament for inhibiting KRAS activity, comprising a compound according to any one of claims 1 to 45 or the composition according to claim 46.

49. A medicament for the treatment of a disease or disorder associated with the activity of KRAS, comprising a compound according to any one of claims 1 to 45 or the composition according to claim 46.

50. The medicament according to claim 49, wherein the disease or disorder is an immune disorder or an inflammatory disorder.

51. The medicament according to claim 50, wherein the immune disorder or the inflammatory disorder is a Ras-related lymphoproliferative disorder and juvenile myelomonocytic leukemia caused by a somatic mutation of KRAS.

52. A medicament for the treatment of cancer in a patient, comprising a compound according to any one of claims 1 to 45 or the composition according to claim 46.

53. The medicament according to claim 52, wherein the cancer is selected from carcinomas, blood cancers, sarcomas, and glioblastomas.

54. The medicament according to claim 53, wherein the blood cancer is selected from myeloproliferative neoplasms, myelodysplastic syndromes, chronic and juvenile myelomonocytic leukemia, acute myeloid leukemia, acute lymphoblastic leukemia, and multiple myeloma.

55. The medicament according to claim 53, wherein the carcinoma is selected from pancreatic cancer, colorectal cancer, lung cancer, bladder cancer, gastric cancer, esophageal cancer, breast cancer, head and neck cancer, cervical cancer, skin cancer, and thyroid cancer.

56. A medicament for the treatment of a disease or disorder associated with the activity of a KRAS protein having a G12C mutation, comprising a compound according to any one of claims 1 to 45 or the composition according to claim 46.

Images