Dermatological treatments and systems using cooling, topicals, and / or abrasion

Abstract

Dermatological treatments and systems using cooling, topicals, and / or abrasion are disclosed herein. The system can include a cold plate and a suspension assembly tip. The suspension assembly tip can be selectively connectable to the cold plate. The suspension assembly tip can include a suspension tip and a suspension. The suspension tip can include a contact surface that can be contacted onto the patient's skin to provide treatment. The suspension can be connected to both the cold plate and the suspension tip. The suspension can be thermally conductive to closely thermally connect the suspension tip to the cold plate, or the suspension tip can have a low thermal conductivity to not closely thermally connect the suspension tip to the cold plate.

Description

[Technical field]

[0001] [CROSS REFERENCE TO RELATED APPLICATIONS] This application claims the benefit of U.S. Provisional Application No. 63 / 139,450, entitled “DERMATOLOGICAL TREATMENTS AND SYSTEMS EMPLOYING COOLING, TOPICALS, AND / OR ABRASION,” filed January 20, 2021, which is incorporated by reference in its entirety. [Background technology]

[0002] Cryotherapy is the local or systemic use of cold in medical therapy. Cryotherapy can involve the controlled freezing of biological tissue, such as skin tissue, which can produce a variety of effects. Certain tissue freezing procedures and devices, such as conventional cryoprobes, can cause severe freezing of tissue and can produce cellular and visible skin damage.

[0003] There is a demand for cosmetic products that can change the appearance of skin or otherwise controllably affect skin appearance and / or pigmentation. This can include lightening or darkening the skin, improving evenness of skin tone, or minimizing wrinkles, etc. For example, it may be desirable to lighten the overall complexion or color of an area of ​​skin to change the overall appearance for cosmetic reasons. It may also be desirable for cosmetic reasons to lighten certain hyperpigmented areas of skin (e.g., freckles, "café au lait" spots, melasma, or dark circles under the eyes, which may result from an excessive local amount of pigment in the skin). Hyperpigmentation can result from a variety of factors (e.g., UV exposure, aging, stress, trauma, inflammation, etc.). Such factors can lead to excess production of melanin (or melanogenesis) in the skin by melanocytes, which can lead to the formation of hyperpigmented areas. Such hyperpigmented areas are typically associated with excess melanin in the epidermis and / or the dermal-epidermal junction, however, hyperpigmentation can also result from excess melanin deposited in the dermis.

[0004] Hypopigmentation of skin tissue has been observed as a side effect in response to temporary cooling or freezing of tissue (such as may occur during conventional cryosurgery procedures). Loss of pigmentation following skin cooling or freezing may result from decreased melanin production, decreased melanosome production, destruction of melanocytes, or inhibition of melanosome transfer or regulation to keratinocytes in the lower regions of the epidermis layer. The resulting hypopigmentation may be long-lasting or permanent. However, it has also been observed that some of these freezing procedures may develop areas of hyperpigmentation (or skin darkening) of skin tissue. The level of increase or decrease in pigmentation may depend on the specific aspects of the cooling or freezing conditions, including the temperature of the cooling treatment and the length of time the tissue is maintained in a frozen state.

[0005] Improved hypopigmentation treatments, devices, and systems have been developed to improve the consistency of skin freezing and overall hypopigmentation. For example, it has been observed that moderate freezing (e.g., -4 to -30 degrees Celsius) in shorter time frames (e.g., 30 to 60 seconds) can produce certain dermatological effects (e.g., affecting the appearance of skin pigmentation (e.g., hypopigmentation)). Cryotherapy can be delivered using a variety of techniques, including the application of a cryogenic spray directly to the patient's skin or the application of a cooled probe or plate to the patient's skin. Exemplary methods and devices are disclosed in U.S. Patent No. 5,393,636, filed Aug. 7, 2009, entitled "METHOD AND APPARATUS FOR DERMATOLOGICAL HYPOPIGMENTATION"; U.S. Patent No. 5,393,636, filed Nov. 16, 2012, entitled "METHOD AND APPARATUS FOR CRYOGENIC TREATMENT OF SKIN TISSUE"; U.S. Patent No. 5,393,636, filed Nov. 16, 2012, entitled "METHOD AND APPARATUS FOR CRYOGENIC TREATMENT OF SKIN TISSUE"; U.S. Patent No. 5,393,636, filed Feb. 12, 2015, entitled "METHOD AND APPARATUS FOR AFFECTING PIGMENTATION OF TISSUE"; U.S. Patent No. 5,393,636, filed Sep. 6, 2016, entitled "MEDICAL SYSTEMS, METHODS, AND DEVICES FOR HYPOPIGMENTATION COOLING"; and U.S. Patent Application Publication No. 2013 / 0236363, entitled "Medical Systems, Methods, And Devices For Hypopigmentation Cooling Treatments," filed September 6, 2016; and U.S. Patent Application Publication No. 2013 / 0236364, entitled "Medical Methods and Systems for Skin Treatment," filed June 2, 2017, each of which is incorporated herein by reference in its entirety. [Prior art documents] [Patent documents]

[0006] [Patent Document 1] US Patent Application Publication No. 2011 / 0313411 [Patent Document 2] US Patent Application Publication No. 2014 / 0303696 [Patent Document 3] US Patent Application Publication No. 2014 / 0303697 [Patent Document 4] US Patent Application Publication No. 2015 / 0223975 [Patent Document 5] US Patent Application Publication No. 2017 / 0065323 [Patent Document 6] U.S. Pat. No. 10,765,467 [Patent Document 7] US Patent Application Publication No. 2017 / 0348143 Summary of the Invention [Problem to be solved by the invention]

[0007] Although the treatment of skin or localized lesions can be achieved by cryotherapy, it may be desirable to provide improved methods, systems, and devices for cryotherapy.In particular, improved designs, controls, and parameters associated with consistent and reliable skin freezing and cryogen delivery to achieve desired skin treatment effects may be beneficial.Therefore, improved dermatological treatments and systems using cooling, topical, and / or abrasion are desirable. [Means for solving the problem]

[0008] The embodiments disclosed herein relate to dermatological treatments and systems using cooling, topicals, and / or abrasion. It can include a system for delivering and / or controlling the delivery of cooling therapy. The system can include hardware and / or software features for facilitating the delivery of such cooling therapy. It can include a handpiece including a cold plate. One or several handpiece tips can be coupled to the cold plate to provide the desired treatment. These handpiece tips can include, for example, smooth tips, textured tips, and / or suspension assembly tips, which can be smooth or textured.

[0009] The suspension assembly tip can include a suspension and a suspension tip. The suspension can be coupled to the cold plate and can be coupled to the suspension tip. The suspension can suspend the suspension tip such that the suspension tip can move relative to the cold plate. This movement can smooth the forces applied to the patient through the suspension tip. Additionally, the suspension can thermally isolate and / or thermally couple the suspension tip to the cold plate. This selective thermal isolation and / or thermal coupling can facilitate wider use of the handpiece for freezing, cooling, and / or other therapies.

[0010] One aspect relates to a system for delivering cooling therapy to an area of ​​a patient's skin. The system includes a cold plate and a suspension assembly tip selectively connectable to the cold plate. The suspension assembly tip can include a suspension tip and a suspension.

[0011] In some embodiments, the system includes a handpiece coupled to the cold plate. In some embodiments, the handpiece includes a chiller capable of controlling a temperature of the cold plate. In some embodiments, the handpiece further includes a button, the button capable of receiving a user input indicating the initiation of treatment.

[0012] In some embodiments, the handpiece further includes a feature capable of detecting contact of the cold plate to the patient's skin. In some embodiments, the feature capable of detecting contact of the cold plate to the patient's skin can be a capacitive touch sensor. In some embodiments, the feature capable of detecting contact of the cold plate to the patient's skin can be a temperature sensor.

[0013] In some embodiments, the system can include a controller communicatively coupled to the chiller. In some embodiments, the controller can control operation of the chiller to control the temperature of the cold plate. In some embodiments, the controller can control operation of the chiller according to stored treatment instructions.

[0014] In some embodiments, the cold plate includes a distal protrusion, a camming surface extending proximally and radially away from a proximal end of the distal protrusion, and a retention recess connecting to the proximal end of the camming surface. In some embodiments, the camming surface is at least partially conically shaped. In some embodiments, the cold plate further includes a plurality of axial grooves positioned around a circumference of the junction of the proximal end of the camming surface and the retention recess. In some embodiments, the retention recess extends below the proximal end of the camming surface to a predetermined retention depth. In some embodiments, the axial groove has a groove depth equal to the retention depth.

[0015] In some embodiments, the suspension tip can be at least one of a smooth tip and a textured tip. In some embodiments, the suspension tip can have an outer housing. In some embodiments, the outer housing can include a contact surface and a base. In some embodiments, the base defines an opening that extends into a receiver defined by an interior wall of the outer housing of the suspension tip. In some embodiments, the receiver can receive the suspension. In some embodiments, the suspension tip further includes a retention groove and a suspension lip. In some embodiments, each of the retention groove and the suspension lip are formed in the receiver by an interior wall of the outer housing. In some embodiments, the retention groove is relatively closer to the base of the outer housing than the suspension lip.

[0016] In some embodiments, the suspension includes a central member located on top of the suspension, a suspension member array including a plurality of suspension members, and a linking member array including a plurality of linking members. In some embodiments, each of the suspension members extends radially from a proximal end connected to the central member. In some embodiments, each of the linking members extends radially and downwardly from a proximal end connected to the central member.

[0017] In some embodiments, the central member defines a central receiver capable of receiving a portion of the cold plate. In some embodiments, the array of connecting members is conically shaped. In some embodiments, a distal end of each of the connecting members includes a connecting head. In some embodiments, at least some of the connecting heads of the connecting members include external connectors capable of engaging the retention grooves.

[0018] In some embodiments, at least some of the coupling heads of the coupling members include internal connectors that can engage with the cold plate. In some embodiments, the internal connectors are capable of engaging with retention grooves in the cold plate. In some embodiments, each of the suspension members engages with a suspension lip. In some embodiments, each of the multiple suspension members in the suspension member array are positioned in a common plane.

[0019] One aspect relates to a suspension assembly tip selectively connectable to a cold plate. The suspension assembly tip includes a suspension tip including an outer housing including a contact surface, an inner surface defining a receiver within the outer housing, and a base. In some embodiments, the base defines an opening that extends into the receiver. The suspension assembly tip includes a suspension coupled to the inner surface of the outer housing. In some embodiments, the receiver is capable of receiving the suspension.

[0020] In some embodiments, the suspension contact surface of the suspension tip includes at least one of a smooth contact surface and a textured contact surface. In some embodiments, the suspension tip further includes a retention groove and a suspension lip. In some embodiments, each of the retention groove and the suspension lip are formed in the inner surface of the outer housing. In some embodiments, the retention groove is relatively closer to the base of the outer housing than the suspension lip.

[0021] In some embodiments, the suspension includes a central member located on top of the suspension, a suspension member array including a plurality of suspension members, and a linking member array including a plurality of linking members. In some embodiments, each of the suspension members extends radially from a proximal end connected to the central member. In some embodiments, each of the linking members extends radially and downwardly from a proximal end connected to the central member.

[0022] In some embodiments, the central member defines a central receiver. In some embodiments, the linking member array is shaped in a cone shape. In some embodiments, a distal end of each of the linking members can include a linking head. In some embodiments, at least some of the linking heads of the linking members can include an external connector that can engage with the retention groove. In some embodiments, at least some of the linking heads of the linking members include an internal connector that can engage with the cold plate. In some embodiments, each of the suspension members engages with a suspension lip. In some embodiments, each of the multiple suspension members in the suspension member array are positioned in a common plane.

[0023] One aspect of the disclosure relates to a method of delivering skin cooling therapy to an area of ​​a patient's skin. The method can include accepting a card into a card reader of a cooling therapy system. The cooling therapy system can include a display, a chiller positioned in a housing, and a hand piece flexibly coupled to the housing. The hand piece can include a chiller for cooling a cold plate of the hand piece. The method can include identifying treatment instructions stored in the card, the treatment instructions including at least one temperature profile, the at least one temperature profile identifying a plurality of temperatures and associated times for ramping to and / or maintaining each of the plurality of temperatures; initiating a graphical user interface (GUI) corresponding to the identified treatment; identifying a step among the plurality of steps in the identified treatment; controlling the GUI to guide a user through performing a user action of the step in the identified treatment; setting a temperature of the cold plate to a first temperature of the temperature profile; and controlling the GUI to display a countdown timer upon receiving an indication of initiation of delivery of a treatment for the identified step. In some embodiments, and after the step of setting the temperature of the cold plate to the first temperature, the cold plate can be pre-cooled until the set temperature of the cold plate is achieved.

[0024] In some embodiments, the step can be a freezing step. In some embodiments, the second step can be a cooling step. In some embodiments, the cooling step can include a step in which the temperature of the treated skin is reduced. In some embodiments, the cooling step can include a step of reducing the temperature of the treated skin so that ice crystallization occurs in the treated skin. In some embodiments, the third step can be a dwell step. In some embodiments, the fourth step can be a rewarming step. In some embodiments, this can include a step of rewarming the skin, for example, to a temperature of up to 50°C, 45°C, 40°C, 35°C, 30°C, between 30°C and 50°C, or between 35°C and 45°C.

[0025] In some embodiments, controlling the GUI to guide the user through performing the next step user action can include identifying at least one topical agent and instructing application of the topical agent to the area of ​​the patient's skin. In some embodiments, controlling the GUI to guide the user through performing the next step user action can include instructing the user to cool the area of ​​the patient's skin via the hand piece. In some embodiments, instructing the user to cool the area of ​​the patient's skin via the hand piece can include instructing the user to contact the area of ​​the patient's skin with a cold plate and to press a button to indicate the start of delivery of the identified next step treatment. In some embodiments, instructing the user to cool the area of ​​the patient's skin via the hand piece can include instructing the user to connect a treatment tip (also referred to herein as a cooling tip) to a cold plate of the hand piece, to contact the area of ​​the patient's skin with the treatment tip connected to the cold plate, and to press a button to indicate the start of delivery of the identified next step treatment.

[0026] In some embodiments, the treatment tip can be at least one of a smooth tip and a textured tip. In some embodiments, the cold plate can include a distal protrusion, a camming surface extending proximally and radially away from the proximal end of the distal protrusion, and a retention recess connecting the proximal end of the camming surface. In some embodiments, the camming surface is at least partially conically shaped.

[0027] In some embodiments, the therapeutic tip includes an outer housing and a retention feature positioned within the outer housing. In some embodiments, the retention feature can be held within the retention recess, thereby connecting the therapeutic tip to the cold plate. In some embodiments, the retention feature can be a rubber O-ring. In some embodiments, the cold plate further includes a plurality of axial grooves positioned around a periphery of the junction of the proximal end of the camming surface and the retention recess. In some embodiments, the plurality of axial grooves prevent sealing of the O-ring to the cold plate when connecting the therapeutic tip to the cold plate.

[0028] In some embodiments, setting the temperature of the cold plate to a first temperature of the temperature profile includes controlling a chiller to cool the coolant to a coolant temperature within the target range, circulating the coolant through the hand piece, and controlling a cooler in the hand piece to cool the cold plate to a desired cold plate temperature. In some embodiments, the cooler can be a thermoelectric cooler. In some embodiments, controlling a cooler in the hand piece to cool the cold plate to a desired cold plate temperature can include transferring heat from the cold plate to the coolant circulating through the hand piece by the thermoelectric cooler. In some embodiments, the chiller can include a coolant circulation system, a heat exchanger, and a refrigeration unit coupled to the coolant circulation system via the heat exchange. In some embodiments, the refrigeration unit can cool the coolant in the coolant circulation system. In some embodiments, the chiller further includes a heating unit capable of heating the coolant in the coolant circulation system.

[0029] In some embodiments, the method can include receiving a termination request and canceling the therapy. In some embodiments, the termination request is received from a user. In some embodiments, the method can include generating a termination request and canceling the therapy. In some embodiments, the termination request is generated by a processor of the cooling therapy system in response to a detected temperature. In some embodiments, the detected temperature can be at least one of a temperature of the cold plate, a temperature of the chiller, or a temperature of the chiller. In some embodiments, canceling the therapy includes controlling the chiller to rewarm the cold plate. In some embodiments, after receiving the termination request, the cold plate is heated. In some embodiments, the cold plate can be heated via control of at least one of the chiller and the chiller. In some embodiments, canceling the therapy includes heating the cold plate. In some embodiments, heating the cold plate includes controlling at least one of the chiller and the chiller to heat the cold plate.

[0030] In some embodiments, the method can further include determining a value of a count of available treatment cycles associated with the card, receiving instructions from a user to provide a treatment, and starting a treatment when the value indicates that at least one treatment is available. In some embodiments, the method can further include decrementing the value of the count of available treatment cycles when starting a treatment. [Brief description of the drawings]

[0031] [Figure 1] FIG. 1 is a schematic diagram of one embodiment of a cold treatment system. [Diagram 2]FIG. 2 is a schematic diagram of electrical components of the cold treatment system. [Diagram 3] FIG. 1 illustrates a perspective view of one embodiment of a cold therapy system including a tabletop console. [Figure 4] FIG. 1 illustrates a rear view of an embodiment of a cold therapy system including a tabletop console. [Diagram 5] FIG. 1 illustrates a perspective view of an embodiment of a cold treatment system with a cord in a boom. [Figure 6] FIG. 1 is a perspective view of a floor-based cooling therapy system. [Figure 7] FIG. 1 is a perspective view of one embodiment of a handpiece. [Figure 8] FIG. [Figure 9] FIG. [Figure 10] FIG. 1 illustrates a perspective view of one embodiment of a smooth tip. [Figure 11] FIG. 13 is a side view of one embodiment of a smooth tip. [Figure 12] FIG. 13 is a cross-sectional view of one embodiment of a smooth tip. [Figure 13] FIG. 13 is a perspective view of one embodiment of a textured tip. [Figure 14] FIG. 13 is a side view of one embodiment of a textured tip. [Figure 15] FIG. 2 is a cross-sectional view of one embodiment of a textured tip. [Figure 16] FIG. 2 illustrates a cross-sectional view of one embodiment of an assembled suspension assembly tip. [Figure 17] FIG. 2 is a cross-sectional view of one embodiment of a suspension tip. [Figure 18] FIG. 2 is a side view of the suspension structure. [Figure 19] FIG. 1 is a perspective view of one embodiment of a suspension structure. [Figure 20] FIG. 1 is a schematic diagram of one embodiment of a chiller. [Figure 21]1 is a flow chart illustrating one embodiment of a process for delivering skin cooling therapy to a patient. [Figure 22] FIG. 1 illustrates one embodiment of a treatment profile. [Figure 23] 13 is a depiction of a GUI that indicates readiness to accept artifacts. [Figure 24] 1 is a depiction of a GUI that is activated in connection with restorative therapy. [Diagram 25] 13 is a depiction of a GUI instructing a user to place the treatment tip on the cold plate. [Figure 26] 1 is a depiction of a GUI instructing a user to press a button on the handpiece. [Figure 27] 1 is a depiction of a GUI that instructs a user to apply a treatment tip to a patient's skin. [Figure 28] 13 is a depiction of a GUI that instructs a user regarding dwell time. [Figure 29] Illustrated is a graphical user interface (GUI) that is activated in relation to cryotherapy. [Diagram 30] 1 is a depiction of a GUI instructing a user to press a button on the handpiece. [Diagram 31] 1 is a depiction of a GUI instructing a user to apply a cold plate to a patient's skin. [Diagram 32] 13 is a depiction of a GUI instructing a user to maintain application of a cold plate to a patient's skin. [Diagram 33] 1 is a graph depicting the measured improvement in a patient's skin after undergoing treatment described herein. [Diagram 34] FIG. 1 includes a photograph of a patient before undergoing the treatment described herein and after undergoing the treatment described herein. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0032] Cooling-based treatments are frequently used to address a wide range of health and aesthetic problems, including, for example, acne (acne vulgaris, cystic acne); keloid acne; sebaceous adenoma; alopecia areata; angiokeratoma; angiokeratoma of Fordyce; atypical fibroxanthoma; cherry angiomas; chondrodermatitis nodularis helix; chromoblastomycosis; clear cell acanthoma; condyloma acuminata; dermatofibroma; disseminated superficial actinic porokeratosis; perforating elastosis serpiginosa; epidermal nevi; nipple erosions. adenomatosis;papillary dermatitis of the head;granuloma annulare;granuloma of the face;pyogenic granuloma;hemangioma;herpes labialis;idiopathic guttate hypopigmentation;Kyrle's disease;leishmaniasis;lentigines;lentigines simplex;vulvar lichen sclerosus atrophicus;lupus erythematosus;lymphangioma;lymphocytoma cutaneous;molluscum contagiosum;mucocele;myxoid cyst;contagious pustular dermatitis (orf);discoid plantar porokeratosis (porokeratosis plantaris discreta); Mibelli porokeratosis; prurigo nodularis; pruritus; psoriasis; rhinophyma; rosacea; sarcoid; sebaceous hyperplasia; seborrheic keratosis; solar lentigo; syringoma; trichiasis; trichoepithelioma; varicose veins; venous lakes; warts (periungual warts, flat warts, common warts, filiform warts, plantar warts); xanthomas; acne scars; keloids; skin horns; hypertrophic scars; ingrown nails; skin tags; tattoos; freckles; spider nevi; capillary hemangiomas; cavernous hemangiomas; miliary tumors; trichilemmal cysts; multiple sebaceous cysts; sweat gland cysts; acral keratosis verrucosa; papular dermatosis black; nevus of nipple hyperkeratosis; benign lichenoid keratosis; angiofibromas; and hemangiomas. In some embodiments, cooling-based therapy can be used to treat precancerous skin conditions, such as, for example, actinic keratosis; leukoplakia; Bowen's disease; erythroplasia of Quyrat; keratoacanthoma; and lentigo maligna, and can be used to treat malignant skin conditions, such as, for example, basal cell carcinoma; Kaposi's sarcoma; squamous cell carcinoma; and melanoma.

[0033] Some of these treatments are specifically designed to cause skin healing, achieve a desired cosmetic benefit, and / or change skin color through producing skin lightening or skin darkening, which can include minimizing lines and / or wrinkles, improving skin roughness, or improving the evenness of skin tone, etc.

[0034] Maximizing the beneficial effects of treatment on the skin can be complicated and can include multiple steps, which can be complex. More specifically, this can include applying one or several topical agents (which can include one or several fluids, pastes, creams, serums, or emollients, etc.), performing one or several skin manipulations or massages, and / or applying one or several cooling or freezing treatments, etc. Cooling or freezing treatments can include cooling the treated skin to a certain temperature and / or temperature range, and in some cases can include maintaining those temperatures and / or temperature ranges for a given time and / or range of time. In some cases, the effectiveness of a treatment depends at least in part on the consistency with which the treatment is applied.

[0035] The present disclosure relates to systems, devices, and methods for improving the delivery of treatments, which in some embodiments can include the delivery of treatments for medical or cosmetic purposes, which can include, for example, changing skin color, such as by causing skin lightening or darkening, ablating lesions, improving skin tone, minimizing lines and wrinkles, and / or promoting skin healing.

[0036] 1, a schematic diagram of one embodiment of a cold treatment system 100 is shown. The cold treatment system 100 may include a body portion 102 (also referred to herein as a housing 102 or a console 102). The body portion 102 may house several of the components of the cold treatment system 100, including, for example, a display 104, a reader 106, a single board computer ("SBC") 108, and a controller 110. The housing 102 may further connect to a boom 103.

[0037] Display 104 may include any desired display and may be configured to provide information to a user of the cooling treatment system 100 and, in some embodiments, may be configured to receive input from a user of the cooling treatment system. In some embodiments, the display may include a touch screen.

[0038] The reader 106 may include features configured to read information from an artifact 107. In some embodiments, the artifact 107 may include a physical artifact, and in some embodiments, the artifact may include a digital token or a non-physical artifact. In some embodiments, the non-physical artifact may be stored, for example, locally or remotely. In some embodiments, the non-physical artifact may reside on and / or be accessible via the cloud.

[0039] This physical artifact 107 can include, for example, any object or token (either physical or digital) that includes computer readable treatment instructions and / or information identifying an associated number of remaining treatment cycles associated with the card. In some embodiments, for example, the number of treatment cycles can track the remaining number of times the artifact 107 can be used in association with the cooling treatment system 100 to provide a treatment to a patient. When the number of remaining treatment cycles reaches zero, then the artifact cannot be used in association with the cooling treatment system 100 to provide further treatments to a patient unless that treatment cycle is reloaded. Thus, in some embodiments, the artifact includes a count of available treatments, which can be decremented as treatments are provided, and which can be increased if / when the artifact is reloaded. In some embodiments, for example, the artifact can be reloaded by a customer purchase (e.g., via the Internet). In such embodiments, after successful processing of a payment, the value of the artifact's count can be incremented by the number of treatments purchased.

[0040] These instructions may include multiple steps and associated treatments, or multiple treatment parameters or conditions, etc. In some embodiments, for example, treatment instructions may be loaded onto the artifact 107, and these instructions may be retrievable from the artifact 107 via the reader 106. In some embodiments, the artifact may include, for example, a microprocessor card (also referred to herein as a smart card). The microprocessor card may communicate with the reader 106, for example, via contact or contactless communication. In some embodiments, for example, the artifact may include multiple contacts (such as those found in Europay, Mastercard, and Visa chips (EMV chips)), which may connect with contacts in the reader 106 to enable reading of the card. In some embodiments, for example, the artifact 107 may contactlessly connect with the reader according to any desired contactless and / or wireless communication standard. In some embodiments, for example, the artifact 107 may be connected to the reader 106 via, for example, NFC, Bluetooth, WiFi, or Ethernet.

[0041] The SBC 108 may include, for example, a processor, associated memory, drivers, and / or a communication bus. The SBC 108 may interface with other components through a communication protocol and, in particular, participate in the control of some of the components of the cooling therapy system 100 (in particular, the console 102). This may include, for example, the display 104, the reader 106, the chiller 211, and / or the antenna 226. In some embodiments, the SBC 108 may support input / output hardware (e.g., one or several display drivers, interface drivers, or USB interface drivers, etc.).

[0042] Controller 110 (also referred to herein as processor 110) may include, for example, a microprocessor (e.g., a microprocessor from Intel® or Advanced Micro Devices, Inc.®, or Texas Instruments, or Atmel, etc.). In some embodiments, controller 110 may include a custom electronics board that may include, for example, features for controlling chiller 211 and / or cooler 230, as well as hardware monitoring capabilities.

[0043] The controller and / or processor 110 can be communicatively coupled to memory, which can be volatile and / or nonvolatile and / or can include volatile and / or nonvolatile portions. In some embodiments, the memory can include information and / or instructions that can be executed by the processor 110. The processor 110 can control all or a portion of the cooling therapy system 100 according to these instructions.

[0044] The body 102 can be connected to the hand piece 112 via a cord 111 (also referred to herein as a cable 111). The cord 111 can flexibly couple the hand piece 112 to the body 102. The cord 111 can physically and communicatively connect the hand piece 112 to the body 102 and / or to components contained within the body 102. In some embodiments, for example, the cord 111 can include one or several wires, tubes, optical fibers, or the like. In some embodiments, the controller 110 in the body 102 can control and / or communicate with the hand piece 112 via the cord 111. In some embodiments, coolant from the body 102 can be transferred to and from the hand piece 112 via the cord. In some embodiments, all or a portion of the weight of the cord 111 can be supported by the boom 103.

[0045] The handpiece 112 includes a hand controller 114 and a cold plate 116 (also referred to herein as a handpiece tip 116, a cryotip 116, and / or a cryotip 116). The hand controller can include, for example, a microprocessor (e.g., a microprocessor from Intel® or Advanced Micro Devices, Inc.®, or Texas Instrument, or Atmel, etc.).

[0046] The hand controller 114 can be communicatively coupled to a memory, which can be volatile and / or nonvolatile and / or can include volatile and / or nonvolatile portions. In some embodiments, the memory can include information and / or instructions that can be executed by the hand controller 114. The hand controller 114 can control all or a portion of the hand piece 112 according to these instructions, and in particular can control the temperature of the cold plate 116.

[0047] The cooling therapy system 100 can further include one or more disposable features that can be contained within the case 118. These features can include one or more tips 119. Specifically, the tips 119 can include a smooth tip 120 and / or a textured tip 122. Each of the smooth tip 120 and the textured tip 122 will be discussed in more detail below. In some embodiments, the case 118 can further include an identifier 124. In some embodiments, the identifier 124 can include a SmartChip, which can be located, for example, in the lid of the box.

[0048] The cold therapy system 100 can further include one or more topical agents 132. These one or more topical agents 132 can be contained within the case 130. In some embodiments, the case 130 can be separate and distinct from the case 118, and in some embodiments, the case 118 and the case 130 can comprise a single case. The case 130 can, in some embodiments, contain an artifact 107 for providing the therapy and the topical agent 130. For example, the artifact 107 within the case 130 can include instructions executable by the controller 110 and / or the hand controller 114 to provide the therapy. The case 130 can further include the topical agent for providing the therapy.

[0049] These topical agents can include, for example, gels (e.g., hydrogels, etc.). Hydrogels can include water, thickeners to increase viscosity, and preservatives. Hydrogels can also include an amount of propylene glycol, alcohol, or the like to depress the freezing point below 0° C. The purpose of the gel is to control the freezing point of the gel, thus affecting the freezing point of the skin, improving heat transfer between the skin and the cold plate, and improving lubrication between the skin and the handpiece tip 116 as it is swept across the skin.

[0050] These topicals 132 can include, for example, Molecular Silk Amino Hydrating Cleanser, which can be a pH-balanced moisturizing cleansing gel that can infuse the skin with essential moisture and nutrients as it removes daily dirt, pollution, SPF, and makeup. This topical can be supercharged with multiple moisturizers, antioxidants, phospholipids, and silk amino acids for the ultimate conditioning cleansing.In some embodiments, this can be, for example, silk amino acids, which can provide powerful antioxidants that provide micronutrients and moisturize the skin; hyaluronic acid, which can provide concentrated moisture to the skin and promote essential moisture retention while plumping the skin; organic safflower oil, which can break down dirt, pollution, and makeup as it moisturizes and nourishes all skin types; organic moringa oil, which can be extremely rich in phytonutrients with excellent repair benefits and can reduce the adverse effects of pollution and external impurities on the skin; ethylated L-ascorbic acid, which is an extremely stable ethylated form of L-ascorbic acid. It can include: oleic acid, which can be a pure form of fatty acid that can help neutralize complexion-dulling sebum and brighten dull skin; lecithin phospholipids, which can be an important source of essential fatty acids to keep skin supple and can form a protective film on the surface of the skin to seal in essential moisture; white tea, which provides antioxidant protection while it soothes the skin; lactic acid, which can be gentler than most AHAs and can act as a nourishing brightener, moisturizing dull skin; and astaxanthin, which can be a powerful antioxidant that aids in moisture retention and elasticity and protects the skin against harmful UV rays.

[0051] In some embodiments, these topical agents 132 can include Peel, which can include a brightening chemical exfoliator for increased skin radiance and luminosity. Peel, in some embodiments, can include 10.5% Glycolic Acid + Lactic Acid + Salicylic Acid, which can be a powerful Alpha Hydroxy Acid (AHA) & Salicylic Acid (BHA) that can reduce blemishes and blackheads, refine large pores, accelerate cell renewal, lighten dark spots while increasing hydration and strengthening the skin barrier; Ethylated L-Ascorbic Acid, which can be a pure form of L-Ascorbic Acid in an ethylated form that is extremely stable and helps neutralize complexion-dulling sebum and brighten dull skin; and Pomegranate Enzymes, which can regulate sebum production, promote hydration, brighten skin and gently exfoliate.

[0052] In some embodiments, these topical agents 132 can include Molecular Saviour Probiotics Treatment Mist, which can be a multitasking skin-restoring and brightening spray mist with sustained hydration. It can also be an anti-evaporation complex to ensure that it sticks to the skin. In some embodiments, the topical agent can be, for example, Lactobacillus Ferment + Lactobacillus Ferment Lysate Filtrate + Yogurt (which can be a powerful probiotic that can produce a healthy balanced skin flora and reduce the appearance of imperfections and redness); 5% Niacinamide (which can improve the appearance of large pores, lighten discolorations, and also improve the health of the skin and its ability to retain moisture); Heavy Water (which can be a special water molecule that is heavier than regular water, so it can withstand conventional evaporation, and the heavy water mist is designed to stick to your skin cells instead of simply disappearing). Zinc PCA (which can be a powerful mineral that promotes skin health); Silver (which can reduce the appearance of blemishes and promotes skin health); Mango extract (which can be an antioxidant that promotes hydration as it effectively reduces the appearance of dullness and brightens the skin); Ergothioneine (which can be a powerful antioxidant that protects the skin from UV radiation and also reduces tanning and sun damage); and Acai berry (a superfood that is rich in micronutrients, brightens the skin, and is a powerful antioxidant).

[0053] In some embodiments, these topical agents 132 can include the Glacial Calming Recovery Mask, which can instantly replenish moisture, soothe, and increase essential microbiome. In some embodiments, the topical agents include Snow Algae, which enhances hydration in the skin for a more supple complexion, increases collagen production for improved texture and appearance, and protects the skin from environmental damage at the cellular level; IceAwake™, which can visibly improve skin appearance by reducing wrinkle depth, increasing complexion radiance, and reducing the appearance of fatigue; Vin-uplift, which can visibly improve skin appearance by reducing wrinkle depth, increasing complexion radiance, and reducing the appearance of fatigue; Lift), which can be a resveratrol-based skin firming ingredient extracted from Swiss ice wine combined with tara gum polysaccharides that minimizes fine lines and smooths the skin; organic safflower oil, which can be a skin-identical lipid that moisturizes and nourishes all skin types; 5% niacinamide, which can improve the appearance of large pores and lighten dark spots, refine pores and lighten dark spots, and improve skin barrier function and its ability to retain moisture; honey extract, which can increase the skin microbiome; beta-glucan, which can provide deep epidermal hydration and skin soothing; and multi-molecular hyaluronic acid, which provides topical and concentrated moisture and moisture retention to the skin while plumping up the appearance of fine lines.

[0054] In some embodiments, these topical agents 132 can include Vitamin C Brighten + Firm Serum, which in some embodiments can be 20% Vitamin C Brighten + Firm Serum, an antioxidant-rich serum formulation that fades dark spots, enhances skin radiance, and protects against sun-induced damage and pollutants while promoting brighter, firmer skin. This topical agent can contain 20% Ethylated L-Ascorbic Acid, which is a pure form of L-Ascorbic Acid in an extremely stable ethylated form that penetrates deep into the dermis / skin to provide superior antioxidant protection, stimulates collagen production, rebuilds the skin barrier, and visibly lightens dark spots; 2% Citrus Cell, which can be extracted from oranges, which actively enhances elasticity and promotes smoother, firmer skin for a renewed complexion; Glutathione, which is a powerful antioxidant that prevents free radical damage and repairs signs of premature skin aging while brightening the skin; and Thiotaine, which is a powerful antioxidant that protects and repairs tired skin while strengthening the skin's delicate barrier.

[0055] In some embodiments, these topical agents 132 can include Peptides & Antioxidants Daily Firming Treatment, a daily moisturizer that can protect the skin against pollution and damage, fight inflammation, firm the skin, and restore a healthy barrier.These topical agents include, for example, teprenone (which can actively extend telomere health, restore a healthy skin barrier, protect DNA, and reduce age spots); horehound extract (which can enhance skin softness and smoothness and refine skin texture, which can further help reduce the appearance of blackheads, leaving skin radiant and clean); palmitoyl tripeptide-5 (which can stimulate collagen production, prevent the formation of wrinkles and reduce their appearance, Improves skin texture, rejuvenates and smooths skin; Palmitoyl Tripeptide-8, which prevents and reverses signs of inflammation, and soothes and relieves irritated skin; Tetrahexyldecyl Ascorbate, which is a stable, oil-soluble form of Vitamin C that penetrates deep into the skin, stimulates collagen production, lightens dark spots and provides free radical protection; Glutathione, Astaxanthin, Thiotin, Phospholipids, and Ceramides, which strengthen the skin's delicate barrier. while protecting and repairing tired skin); Lactobacillus Ferment (which is a powerful probiotic that produces a healthy balanced skin flora, strengthens the skin's natural defenses, and reduces the appearance of breakouts and redness); Hydrolyzed Mullein Flower (which protects the skin against harmful light energy sources such as UV and blue light); Hyaluronic Acid (which can be a low molecular weight hyaluronic acid, which provides concentrated moisture to the skin and essential nutrients). It can contain: Caffeine (which provides instant tightening and de-puffing and antioxidant protection); Raspberry Seed Oil + Acai Oil (which provides superior antioxidant protection and provides essential fatty acids, hydration, and micronutrients to the skin); Moringa Extract (which purifies the skin and prevents pollution particles from sticking to and damaging the skin); and Niacinamide (which brightens the skin and improves the skin barrier function and its ability to retain moisture).

[0056] In some embodiments, these topical agents 132 can include RESET Acai & Manuka Honey Nourishing Cleanser, which can be, for example, a pH-balanced (pH 4.5), fragrance-free and sulfate-free creamy cleanser that is supercharged with Manuka Honey UMF 17+, acai oil+ extract, yogurt and grape seed oil for a nourishing cleanse with every wash. This can include, for example, Acai Oil + Extract (which can provide superior antioxidant protection and provide the skin with essential fatty acids, hydration, and micronutrients); Grapeseed Oil (which can break down dirt, pollution, and makeup as it moisturizes and nourishes all skin types); Yogurt (which has powerful probiotics that produce a healthy balanced skin flora, promote cell renewal, strengthen the skin's natural defenses, and reduce blemishes and redness); and Medical Grade Manuka Honey UMF 17+ (which can be sourced from sustainable bee farms in New Zealand, Medical Grade Manuka Honey provides natural antibacterial properties, reduces inflammation, and stimulates cell repair in damaged skin).

[0057] In some embodiments, these topical agents 132 can include FOLLOW THE LIGHT Peel, which can be a 20-minute brightening peel that moisturizes and erases signs of dullness as it brightens and refines the appearance of large pores. This peel contains, for example, 6.5% Glycolic Acid + Lactic Acid + Salicylic Acid (whose powerful Alpha Hydroxy Acids (AHAs) & Salicylic Acid reduce blemishes and blackheads, refine large pores, accelerate cell renewal, lighten dark spots, while increasing hydration and strengthening the skin barrier); Pomegranate Enzyme (which regulates sebum production, promotes hydration, brightens and gently exfoliates the skin); Hyaluronic Acid + Crosslinked Hyaluronic Acid (whose next generation pure hyaluronic acid provides concentrated moisture to the skin, promotes protective moisture retention, and promotes hydration ... It may contain: Centella Asiatica (which promotes repair and healing, relieves sensitivity and rebuilds the skin barrier); Licorice Root Extract + White Tea (which provides antioxidant protection as it brightens and moisturizes dull skin); and Glutathione + Vitamin E + Astaxanthin (which prevents UV damage, recycles Vitamin C, provides cellular energy to skin cells so they function better, and also protects the skin from oxidative and cellular damage).

[0058] In some embodiments, these topical agents 132 can include PSA Niacinamide Glow Mist, which can be a multitasking skin-restoring and brightening spray mist with sustained hydration. It can include, for example, Niacinamide (which can improve the appearance of large pores and lighten dark spots, improve pores and lighten dark spots, and improve skin barrier function and its ability to retain moisture); Zinc PCA (which can be a powerful mineral that reduces blemishes and promotes skin health); Centella Asiatica (which provides antioxidant protection while it soothes and tightens the skin); and Licorice Root Extract (which provides antioxidant protection as it brightens and moisturizes dull skin).

[0059] In some embodiments, these topical agents 132 can include the Glacial Brightening Microbiome Treatment Mask, which can instantly replenish moisture, soothe, and increase essential microbiome. This can include, for example, Snow Algae, which can increase hydration in the skin for a more supple complexion, increase collagen production for improved texture and appearance, and protect the skin from environmental damage at the cellular level; IceAwake™, which can visibly improve skin appearance by reducing wrinkle depth, increasing complexion radiance, and reducing the appearance of fatigue; Vin-uplift, which can visibly improve skin appearance by reducing wrinkle depth, increasing complexion radiance, and reducing the appearance of fatigue; Lift), which is a resveratrol-based skin firming ingredient extracted from Swiss ice wine combined with tara gum polysaccharides that minimizes the appearance of fine lines and smooths the skin; Organic Safflower Oil, which is a skin-identical lipid that moisturizes and nourishes all skin types; Niacinamide, which improves the appearance of large pores and lightens dark spots, refines pores and lightens dark spots, and also improves the skin barrier function and its ability to retain moisture; Honey Extract, which increases the microbiome; Beta-Glucan, which provides deep epidermal hydration and skin soothing; and Multimolecular Hyaluronic Acid, which provides topical and concentrated moisture and moisture retention to the skin while plumping up the appearance of fine lines.

[0060] In some embodiments, these topicals 132 can include LIQUID PANACEA Centella & Kombucha Firming Recovery Booster, which can be a super-antioxidant booster supercharged with 6% Kombucha + White Tea, 5% Centella Stem Cell & Extract, Madecassoside, and 3% Vitamin E that is designed to repair and firm all skin types while reducing signs of premature aging and fatigue. This can include, for example, 6% Kombucha + White Tea (its powerful antioxidants protect, firm and brighten tired skin, on the one hand strengthening the skin's delicate barrier and reducing the effects of glycation); 5% Centella Stem Cells + Centella Extract (it promotes repair and healing, relieves sensitivity, rebuilds the skin barrier and on the other hand improving the appearance of lines and wrinkles); 3% Vitamin E (it is a powerful antioxidant that protects and brightens tired skin, on the other hand strengthening the skin's delicate barrier); Madecassoside (it is an important component of Centella asiatica that stimulates the repair and recovery of tired skin).

[0061] In some embodiments, these topical agents 132 can include GIFTED Acai & Sea Buckthorn Vitamin C Glow Oil. In some embodiments, this can be a glow-inducing brightening oil with a smart blend of 5% Vitamin C, 2% Vitamin E, and six cold-pressed oils supercharged with CoQ10 complex for visible skin radiance and nourishment. This can include, for example, 5% Vitamin C (which is a stable, oil-soluble form of Vitamin C that penetrates deep into the skin, stimulates collagen production, lightens dark spots, and provides free radical protection); 2% Vitamin E (which is a powerful antioxidant that protects and brightens tired skin while strengthening the skin's delicate barrier); Acai Oil (which is rich in vitamins and antioxidants that restore skin elasticity while increasing cell turnover and collagen production, giving the skin a radiant complexion); Organic Red Raspberry Oil (which is rich in vitamins and antioxidants that restore skin elasticity while increasing cell turnover and collagen production, giving the skin a radiant complexion); It can contain: Coenzyme Q10, which is a powerful antioxidant oil that reduces the appearance of age spots and wrinkles and improves skin elasticity and suppleness; Coenzyme Q10, which is a powerful antioxidant that acts against oxidative damage and protects the skin against photoaging by stimulating collagen production; and Grapeseed + Squalane + Sea Buckthorn Oil, which are oils that contain over 100 bioactive nutrients, antioxidants, vitamins, and minerals and which penetrate deep into the skin, nourishing it and stimulating repair.

[0062] 2, there is shown a schematic diagram of the electrical components of the cooling treatment system 100. The body 102 may include a controller 110, which may include a USB chip 202. The USB chip 202 may convert communications to and from USB signals.

[0063] The controller 110 can receive power from a power source 204, which is connected to a power entry 206. In some embodiments, the power entry 206 can include any feature configured to receive power from a source external to the cooling treatment system 100 and deliver the power to the power source 204. The power entry 206 can include a power cord or a power plug, in some embodiments.

[0064] The power supply 204 may provide power to the controller 110 and, via the controller 110, to some or all of the powered components of the cooling treatment system 100. The power supply may include an AC / DC converter that may receive AC power from, for example, the power entry 206 and convert the AC power to DC. In some embodiments, the power supply 204 may include a 1000W AC / 24V DC converter.

[0065] The controller 110 can power and communicate with the heat load 206 and the temperature sensor 208. The heat load 206 can include a heater configured to heat a portion of the chiller, and in particular, to heat the coolant traveling through the chiller. The heat load 206 can include a resistive heater, and the resistive heater can include, for example, one or several resistive heating elements. The temperature sensor 208 can be configured to sense a temperature within the body 102, and in particular, the temperature of the heat load 206 and / or the temperature of the coolant traveling through the heat load 206.

[0066] The controller 110 may further power a driver 210, which may drive one or several components of the cooling treatment system 100 (including, for example, a fan and / or a chiller).

[0067] The body 102 may include a chiller 211, which may be configured to chill a coolant to a coolant temperature within a target range. The chiller 211 may include multiple components (e.g., including a refrigeration unit 212, a pump 220, and a temperature sensor 216) that are powered and / or controlled by the controller 110. In some embodiments, the chiller 211 may be cooled by one or more fans 214, which may be powered by the controller 110, and the level of the coolant in the chiller 211 may be detected by a liquid sensor 218, which may be a liquid level sensor. In some embodiments, the chiller 211 may include a heat exchanger (e.g., a heat exchanger including a plurality of fins and a fan configured to blow air across the fins, etc.).

[0068] The controller 110 can provide regulated DC power to the SBC 108, the display 104, and the panel 222. The SBC 108 can then power the reader 106 and the antenna 226, and can communicate with each of the display 104, the reader 106, and the antenna 226. In some embodiments, these communications can include, for example, USB signals.

[0069] In addition to powering the panel, the controller 110 can maintain a communication connection with the panel 222 and the USB 224. In some embodiments, the panel 222 can include an interface and the cable 111 can connect to the body 102 through the interface. In some embodiments, for example, the cable 111 can be connected to the panel 222 such that the handpiece board 228 (which is a circuit board in the handpiece 112 that contains the hand controller 114) is powered and / or communicatively connected to the controller 110 via the cable 111. In some embodiments, the cooler 230 is powered and / or controlled by the controller 110 via the cable 111.

[0070] The cooler 230 can be configured to control the cold plate temperature of the cold plate 116. In some embodiments, the cooler 230 can include a thermoelectric cooler (TEC), which can transfer thermal energy from the cold plate 116. In some embodiments, the cooler 230 can be configured to transfer this thermal energy to a reservoir (e.g., the coolant circulated from the chiller 211 through the handpiece 112, etc.).

[0071] The handpiece 112 may further include a motor 232, capacitive touch sensor electronics 234 (also referred to herein as cap touch 234), one or more temperature sensors 236, a speaker 238, and one or more input features 240. In some embodiments, each of these components of the handpiece 112 may be powered and / or controlled by the controller 110.

[0072] The motor 232, in some embodiments, can be configured to provide haptic feedback and / or tissue vibrations. In some embodiments, the vibrations can be transmitted to the tissue being treated. In some embodiments, these vibrations transmitted to the tissue being treated can cause an effect on the tissue being treated. In some embodiments, this can include, for example, causing ice nucleation.

[0073] The cap touch 234 can include an electrical circuit electrically coupled to the cold plate 116. The cap touch 234 can include, for example, a capacitive touch sensor. In some embodiments, the cap touch 234 can be configured to sense a change in capacitance when the cold plate 116 (or one of the tips 119 coupled to the cold plate 116) contacts the skin or is removed from contact with the skin. In some embodiments, this can enable an automatic start of treatment by determining when the hand piece 112 contacts the patient's skin or an end of treatment when it is removed from the patient's skin. In some embodiments, a countdown time can be triggered as a result of the detection of contact of the hand piece tip 116 with the patient's skin.

[0074] In some embodiments where freezing or cooling therapy is provided, the cap touch 234 can detect when the cold plate 116 (or one of the tips 119 coupled to the cold plate 116) comes into contact with the skin. In such embodiments, a countdown timer can be started for that therapy step when contact is detected. In some embodiments where a dwell time is provided, the cap touch 234 can detect when the cold plate 116 (or one of the tips 119 coupled to the cold plate 116) is removed from contact with the skin. In such embodiments, a countdown timer can be started for the dwell time when removal from contact is detected.

[0075] Temperature sensor 236 can be configured to sense one or more temperatures of hand piece 112. This can include, for example, sensing one or more temperatures of cold plate 116 and / or one or more temperatures of hand piece 112 (e.g., the temperature of cooler 230). In some embodiments, based on the sensed temperature, cooler 230 can increase or decrease its cooling of cold plate 116.

[0076] Handpiece 112 further includes a speaker 238 and a control 240. Speaker 238 can include an output device configured to provide information to a user of cooling treatment system 100. Control 240 can include one or more input features (e.g., one or more buttons). In some embodiments, a user can manipulate control 240 to provide one or more inputs to cooling treatment system 100, and cooling treatment system 100 can provide information to the user via speaker 238.

[0077] 3 and 4 show diagrams of an embodiment of the cooling treatment system 100, and in particular, a tabletop embodiment of the cooling treatment system 100. Referring now to FIG. 3, a perspective view of an embodiment of the cooling treatment system 100 is shown. As can be seen, the cooling treatment system 100 includes a body portion 102, a display 104, and a reader 106. In the embodiment of FIG. 3, the reader 106 includes a slot that is configured to receive an artifact 107, and in particular, a card, such as a microprocessor card. The cooling treatment system 100 further includes a retention receptacle 300. The retention receptacle is configured to receive a portion of the handpiece 112 to hold, secure, and / or retain the handpiece 112. The cooling treatment system 100 further includes a handle 302. In some embodiments, the handle 302 includes a first handle positioned on a first side of the body portion 102 and a second handle positioned on a second, opposite side of the body portion 102. The handle 302 can be positioned such that a person can insert their fingers into and remove their fingers from the handle 302 when the body portion 102 is positioned on a flat surface.

[0078] 4, there is shown a rear view of one embodiment of the cooling treatment system 100. As can be seen, the cable 111 and the handpiece 112 are attached to the body portion 102, and more specifically, to the body portion 102 of the cooling treatment system 100 via a number of mounting brackets 400.

[0079] 5, a perspective view of one embodiment of a cold treatment system 100 is shown. Cold treatment system 100 includes a body 102, a boom 103, a display 104, and a reader 106. As can be seen in FIG. 5, a cable 111 extends through and is supported and / or partially supported by the boom 103. A handpiece 112 is connected to the side of the body 102 via a retention receptacle 300, which is not visible.

[0080] 6, a perspective view of another embodiment of the cooling treatment system 100 is shown, and in particular, a perspective view of a floor-based cooling treatment system 100 is shown. The cooling treatment system 100 includes a wheeled cart 600. The wheeled cart 600 can, in some embodiments, contain some or all of the components in the body 102 shown in FIGS. 1 and 2. As seen in FIG. 6, the wheeled cart 600 includes a number of wheels 602 connected to a base 604. A housing 606 is mounted on the base 604. The housing 606 can contain, for example, the chiller 211, the power supply 204, the power entry 206, or the controller 110.

[0081] A vertical support 608 may extend vertically from the housing 606. The vertical support 608 may be coupled to and may support the display 104 and the boom 103. In some embodiments, and as seen in FIG. 6 , the cable 111 may be coupled to a portion of the vertical support 608.

[0082] Although both embodiments shown in Figures 3-6 are of a cooling treatment system 100, these embodiments may have different performance attributes. For example, the embodiment of Figures 3-5 may provide different cooling levels than the embodiment shown in Figure 6. For example, the embodiment of Figures 3-5 may provide cold plate 116 cooling / temperature control of -10°C to +40°C, while the embodiment of Figure 6 may provide cold plate cooling / temperature control of -30°C to +40°C. However, in some embodiments, all of the embodiments of Figures 3-6 may provide cold plate cooling / temperature control of -30°C to +40°C.

[0083] 7, there is shown a perspective view of one embodiment of handpiece 112. As seen in FIG 7, handpiece 112 connects to cable 111. Handpiece 112 includes cold plate 116. Cold plate 116 is capable of being controllably cooled to enable delivery of cooling and / or cryotherapy.

[0084] The handpiece 112 further includes an input feature 700. In some embodiments, and as depicted in FIG. 7, the input feature may include a button. The handpiece 112 further includes a retention connector 702. The retention connector 702 may be received by the retention receptacle 300, thereby coupling the handpiece 112 to the console 102 and / or the cart 600.

[0085] 8, a perspective view of the cold plate 116 is shown. The cold plate 116 includes a distal protrusion 800. The distal protrusion may include a cylindrically shaped member that extends radially along and around an axis 801. The distal protrusion 800 may include a distal end 802 and a proximal end 804. The distal end 802 may include a planar member that, in some embodiments, may extend perpendicular to the axis 801.

[0086] The proximal end 804 of the distal projection 800 can be coupled to a camming surface 806. The camming surface 806 can extend proximally and radially away from the proximal end 804 of the distal projection 800. The camming surface 806 can define a frusto-conical shape, and specifically, the camming surface includes a frustum of a frusto-conical shape. Thus, in some embodiments, the camming surface 806 is at least partially conically shaped.

[0087] As seen in Figure 9 (a side view of the cold plate 116), the camming surface 806 can have a distal end 808 that can connect directly or indirectly to the proximal end 804 of the distal projection 800. In the embodiment of Figure 9, the distal end 808 of the camming surface 806 connects to the proximal end 804 of the distal projection via a smoothing feature 810, which can include, for example, a blend or round. The camming surface 806 can further include a proximal end 812.

[0088] The cold plate 116 may further include a retention recess 814 that extends proximally and radially inward from the proximal end 812 of the camming surface 806. As such, a diameter of at least a portion of the retention recess 814, as measured from the axis 801, may be smaller than a diameter of the proximal end 812 of the camming surface 806. In other words, the retention recess 814 may have a predetermined depth below the proximal end 812 of the camming surface 806.

[0089] In some embodiments, the cold plate 116 can further include a plurality of axial grooves 816 extending around the circumference of the camming surface proximal end 812. In some embodiments, each of these axial grooves 816 can be positioned at the junction of the proximal end 812 of the camming surface 806 and the retention recess 814. In some embodiments, each of the axial grooves 816 can extend into the proximal end 812 of the camming surface 806 to a depth equal to the depth of the retention recess 814.

[0090] In some embodiments, the cold plate 116 (specifically, the distal end 802 of the distal projection 800) can be applied directly to the patient's skin to provide cooling and / or cryotherapy. In some embodiments, one or several treatment tips 119 (also referred to herein as treatment caps 119) can be coupled to the cold plate 116 and applied directly to the patient's skin to provide treatment, which can include, for example, skin abrasion treatment, cooling treatment, and / or cryotherapy. Referring now to FIG. 10, a perspective view of one embodiment of the smooth tip 120 is shown. The smooth tip 120 can include an outer housing 1000, a contact surface 1002, and a base 1004. The contact surface 1002 can include a variety of shapes and sizes. In some embodiments, the contact surface 1002 can include a circular surface, which can include, for example, a diameter between 5 mm and 40 mm, a diameter between 10 mm and 30 mm, or any other or intermediate diameter. In some embodiments, the contact surface 1002 can include a square or rectangular surface, which can include a length and / or width between 5 mm and 40 mm, between 10 mm and 30 mm, or any other or intermediate size. In some embodiments, the contact surface 1002 of the smooth tip 120 can be smooth. In some embodiments, the smooth tip 120 can have a roughness Rz between 5 microns and 50 microns, between 10 microns and 40 microns, between 20 microns and 30 microns, a roughness Rz of approximately 25 microns + / - 10 microns, a roughness Rz of approximately 25 microns + / - 5 microns, or any other or intermediate value of roughness Rz. As seen in FIG. 11 (side view of the smooth tip 120), the contact surface 1002 can be curved in some embodiments. The outer housing 1000 of the smooth tip 120 may define a recess 1006 that extends around the housing 1000 .

[0091] 12, a cross-sectional view of the smooth tip 120 is shown. As seen in FIG. 12, the housing 1000 can define an opening 1200 in the base 1004 of the housing 1000 that can extend into a receiver 1202 defined by the housing 1000. The receiver 1202 can be configured to receive the cold plate 116. The receiver 1202 can be defined by a mating surface 1204 that has a shape that is generally or partially the same as a portion of the cold plate 116 (specifically, the distal projection 800 and the camming surface 806). These mating surfaces 1204 may be configured to mate and / or directly or indirectly contact the cold plate 116 (specifically, with the distal protrusion 800 and / or the camming surface 806) to facilitate heat transfer from the smooth tip 120 to the cold plate 116. In some embodiments, the smooth tip 120 may be thermally coupled to the cold plate 116 via these mating surfaces 1204, and in some embodiments, via a thermally conductive coupling fluid applied to the mating surfaces 1204 and / or the cold plate 116.

[0092] The smooth tip 120, and in particular the housing 1000, can include a retention feature 1206, which in some embodiments can include a compliant member coupled to the housing 1000. As particularly depicted in FIG. 12, the retention feature 1206 includes a compliant member in the form of an O-ring 1208 (e.g., a rubber O-ring, etc.) that is retained within a recess 1210 defined by the housing 1000. In some embodiments, the compliant member, and in particular the O-ring 1208, can be configured to be received and retained within a retention recess 814 of the cold plate 116 when the smooth tip 120 is coupled to the cold plate 116. As discussed below, all of the tips 119 can include similar retention features to enable the tips 119 to be coupled to the cold plate 116.

[0093] In some embodiments, for example, when the smooth tip 120 is coupled to the cold plate 116, the compliant member, specifically the O-ring 1208, may engage the camming surface 806, causing the diameter of the compliant member (specifically the O-ring 1208) to deform (specifically expand). This deformation of the compliant member may occur until the cold plate 116 is inserted sufficiently into the receiver 1202 of the smooth 120 housing 1000 such that the compliant member (more specifically the O-ring 1208) is received in the retention recess 814. Due to the smaller diameter of the retention recess 814, the compliant member may return to its undeformed or less deformed shape. This may include a decrease in the diameter of the O-ring. This return to the undeformed or less deformed shape keeps the smooth tip 120 on the cold plate 116. The smooth tip 120 can be released from the cold plate 116 by applying sufficient force to extract the compliant member from the retention recess 814 .

[0094] In some embodiments, the axial grooves 816 can facilitate coupling and decoupling of the smooth tip from the cold plate. Specifically, these axial grooves 816 prevent the compliant member (specifically, the O-ring 1208) from sealing around the cold plate 116. Preventing this sealing in turn prevents the creation of a vacuum when the smooth tip 120 is removed from the cold plate 116, or the creation of pressurized gas or fluid when the smooth tip 120 is coupled to the cold plate 116.

[0095] In some embodiments, the absence of axial grooves 816 may result in the trapping of air between the cold plate and the therapy tip 119. Trapped air may have several disadvantages. Specifically, in embodiments in which the therapy tip 119 is thermally connected to the cold plate to enable the delivery of cooling and / or cryotherapy, this trapped air may reduce the thermal coupling between the cold plate and the therapy tip. Additionally, this trapped air may reduce the stability of the connection of the therapy tip 119 to the cold plate.

[0096] 13-19 show views of embodiments of tip 119, and specifically, show views of textured tip 122. In some embodiments, textured tip 122 can be sufficiently textured to abrade the skin when textured tip 122 is rubbed over the skin.

[0097] As seen in FIG. 13, a perspective view of the textured tip 122 can include an outer housing 1300, a contact surface 1302, and a base 1304. The contact surface 1302 can be flat, planar, non-planar, dimpled, concave, or convex. The contact surface 1002 can include a variety of shapes and sizes. In some embodiments, the contact surface 1002 can include a circular surface, which can include, for example, a diameter between 5 mm and 40 mm, between 10 mm and 30 mm, or any other or intermediate diameter. In some embodiments, the contact surface 1002 can include a square or rectangular surface, which can include a length and / or width between 5 mm and 40 mm, between 10 mm and 30 mm, or any other or intermediate size. In some embodiments, the contact surface 1302 of the textured tip 122 can be textured. In some embodiments, the textured tip 122 can have a roughness Rz between 50 microns and 270 microns, between 60 microns and 200 microns, between 70 microns and 150 microns, approximately 100 microns + / - 20 microns, approximately 100 microns + / - 10 microns, approximately 100 microns + / - 5 microns, approximately 80 microns + / - 10 microns, approximately 80 microns + / - 5 microns, approximately 75 microns + / - 10 microns, approximately 75 microns + / - 5 microns, or any other or intermediate value roughness Rz. As seen in FIG. 14 (a side view of the textured tip 122), the contact surface 1302 can be curved in some embodiments. The outer housing 1302 of the textured tip 122 may define a number of recesses 1306 that extend around the housing 1000 .In some embodiments, the smooth tip 120 and the textured tip 122 can have a different number of recesses 1006, 1306 to allow for easy visual or tactile distinction between the smooth tip 120 and the textured tip 122.

[0098] 15, a cross-sectional view of the textured tip 122 is shown. As seen in the textured tip 122, the housing 1300 can define an opening 1200 in a base 1304 of the housing 1300 that can extend into a receiver 1202 defined by the housing 1300. The receiver 1202 can be configured to receive the cold plate 116. The receiver 1202 can be defined by a mating surface 1204 that has a shape that is generally or partially the same as a portion of the cold plate 116 (specifically, the distal projection 800 and the camming surface 806). These mating surfaces 1204 may be configured to mate and / or directly or indirectly contact the cold plate 116 (specifically, with the distal protrusion 800 and / or the camming surface 806) to facilitate heat transfer from the smooth tip 120 to the cold plate 116. In some embodiments, the smooth tip 120 may be thermally coupled to the cold plate 116 via these mating surfaces 1204, and in some embodiments, via a thermally conductive coupling fluid applied to the mating surfaces 1204 and / or the cold plate 116.

[0099] The textured tip 122, and in particular the housing 1300, can include a retention feature 1206, which in some embodiments can include a compliant member coupled to the housing 1300. As particularly depicted in FIG. 15 , the retention feature 1206 includes a compliant member in the form of an O-ring 1208 (e.g., a rubber O-ring, etc.), which is retained within a recess 1210 defined by the housing 1300. In some embodiments, the compliant member, and in particular the O-ring 1208, can be configured to be received and retained within a retention recess 814 of the cold plate 116 when the textured tip 122 is coupled to the cold plate 116.

[0100] In some embodiments, for example, when the textured tip 122 is coupled to the cold plate 116, the compliant member, specifically the O-ring 1208, may engage the camming surface 806, causing the diameter of the compliant member (specifically the O-ring 1208) to deform (specifically expand). This deformation of the compliant member may occur until the cold plate 116 is inserted sufficiently into the receiver 1202 of the smooth 120 housing 1300 such that the compliant member (more specifically the O-ring 1208) is received in the retention recess 814. Due to the smaller diameter of the retention recess 814, the compliant member may return to its undeformed or less deformed shape. This may include a decrease in the diameter of the O-ring. This return to the undeformed or less deformed shape keeps the textured tip 122 on the cold plate 116. The textured tip 122 can be released from the cold plate 116 by applying sufficient force to extract the compliant member from the retention recess 814 .

[0101] In some embodiments, the axial grooves 816 can facilitate smooth tip coupling and decoupling from the cold plate. Specifically, these axial grooves 816 prevent the compliant member (specifically, O-ring 1208) from sealing around the cold plate 116. Preventing this sealing in turn prevents the creation of a vacuum when the textured tip 122 is removed from the cold plate 116, or the creation of pressurized gas or fluid when the textured tip 122 is coupled to the cold plate 116.

[0102] 16, a cross-sectional view of one embodiment of tip 199 is shown, and in particular, a cross-sectional view of a suspension assembly tip 1600. Suspension assembly tip 1600 includes a suspension tip 1602 and a suspension 1604. Suspension 1604 is configured to engage both suspension tip 1602 and cold plate 116.

[0103] The suspension assembly tip 1600 provides several advantages including, for example, selectively thermally isolating the suspension tip 1602 from the cold plate 116. In some embodiments, for example, the suspension 1604 can include a thermal insulator that can thermally isolate the suspension tip 1602 from the cold plate 116. Alternatively, in some embodiments, the suspension 1604 can include a thermal conductor, thereby intimately thermally coupling the suspension tip 1602 to the cold plate 116. In some embodiments, the suspension tip 1602 is thermally isolated from the cold plate 116 when the suspension tip 1602 maintains a surface temperature of 20° C. or greater, 10° C. or greater, a temperature between 10° C. and 20° C., or any other or intermediate temperature while treatment is being provided. In some embodiments, the suspension tip 1602 is thermally isolated from the cold plate 116 when the suspension tip 1602 maintains a surface temperature above 20° C., above 10° C., above a temperature between 10° C. and 20° C., or any other temperature above the temperature of the cold plate 116 and / or above the temperature of the cold plate 116 and below the temperature of the patient's skin. In some embodiments, the suspension tip 1602 can be sufficiently thermally isolated to maintain a surface temperature above 20° C. when the cold plate 116 is at a temperature between 20° C. and −30° C. In some embodiments, the suspension tip 1602 is intimately thermally coupled to the cold plate 116 when the suspension tip does not maintain a surface temperature above 20° C. while treatment is being provided.

[0104] In some embodiments, the suspension assembly tip 1600 can apply a more consistent and uniform force to the treatment area. Specifically, as the suspension assembly tip 1600 is moved across the treatment area, the suspension 1604 allows the suspension tip 1602 to move relative to the cold plate 116, thereby adjusting to the topography of the treatment area. This results in more consistent contact between the suspension tip 1602 and the skin in the treatment area, and more consistent force between the suspension tip 1602 and the skin in the treatment area.

[0105] The suspension tip 1602 can include an outer housing 1300, a contact surface 1302, and a base 1304. The contact surface 1302 can be flat, planar, non-planar, dimpled, concave, or convex. The contact surface 1002 can include a variety of shapes and sizes. In some embodiments, the contact surface 1002 can include a circular surface, which can include, for example, a diameter between 5 mm and 40 mm, between 10 mm and 30 mm, or any other or intermediate diameter. In some embodiments, the contact surface 1002 can include a square or rectangular surface, which can include a length and / or width between 5 mm and 40 mm, between 10 mm and 30 mm, or any other or intermediate size. In some embodiments, the contact surface 1302 can be smooth or textured. In some embodiments, the textured tip 122 can have a roughness Rz between 50 microns and 270 microns, a roughness Rz between 60 microns and 200 microns, a roughness Rz between 70 microns and 150 microns, a roughness Rz of approximately 100 microns + / - 20 microns, a roughness Rz of approximately 100 microns + / - 10 microns, a roughness Rz of approximately 100 microns + / - 5 microns, a roughness Rz of approximately 80 microns + / - 10 microns, a roughness Rz of approximately 80 microns + / - 5 microns, a roughness Rz of approximately 75 microns + / - 10 microns, a roughness Rz of approximately 75 microns + / - 5 microns, or any other or intermediate value.

[0106] 17, the housing 1300 can define an opening 1200 in a base 1304 of the housing 1300 that can extend into a receiver 1202 defined by the housing 1300 (specifically, by an interior wall 1702 of the housing 1300). The receiver 1202 (which can be defined by and / or formed within the interior wall 1702 of the housing 1300) can be configured to retain and / or engage the suspension 1604, as well as to receive the cold plate 116.

[0107] In some embodiments, the receiver 1202 can include a retention groove 1606 and a suspension lip 1608, where the retention groove 1606 is configured to engage a portion of the suspension 1604 to couple the suspension 1604 to the suspension tip 1602. As shown in FIG. 17 , each of the suspension lip 1608 and the retention groove 1606 can be formed in and / or by the interior wall 1702 of the housing. In some embodiments, the suspension lip 1608 can be formed in the interior wall 1702 of the housing 1300 at a location relatively closer to the contact surface 1302 than the base 1304 of the housing 1300. In some embodiments, the suspension groove 1606 can be formed in the interior wall 1702 of the housing 1300 at a location relatively closer to the base 1304 of the housing than the contact surface 1302 of the housing 1300.

[0108] The suspension groove 1606 can be sized and shaped to receive and retain a tip connection feature (such as, for example, the external connector 1820 of the suspension 1604). In some embodiments, the suspension groove 1606 can be sized and / or shaped to allow some movement of the tip connection feature relative to the suspension groove 1606 and / or relative to the suspension 1606. When the suspension assembly tip 1600 is connected to the cold plate 116, then the suspension groove 1606 can be sized and / or shaped to allow some movement of the suspension tip 1602 relative to the cold plate 116. In some embodiments, both the tip connection feature and the suspension groove 1606 can be sized and / or shaped to allow the tip connection feature to move, for example, up to 1 mm, 2 mm, 3 mm, 4 mm, 5 mm, 6 mm, 7 mm, or any other or intermediate distance, relative to the suspension groove. In some embodiments, this movement can be in the direction indicated by arrow 1620.

[0109] The suspension lip 1608 can be configured to engage one or more features of the suspension 1604, thereby suspending the suspension tip 1602. The suspension lip 1608 can extend around all or a portion of the receiver 1202. In some embodiments, the suspension lip 1608 can extend circumferentially around the interior of the receiver 1202 to form a continuous rim that can engage with one or more suspension members 1810. The one or more suspension members 1810 can each include, for example, a flexible element extending from a central member 1804 of the suspension 1604. In some embodiments, each of the suspension members 1810 can include a torsion bar, the torsion bar configured to apply a force to the suspension lip 1608 to bias the suspension tip 1602 toward a stable position. In some embodiments, the suspension 1604 drives the suspension tip 1602 to a stable position when no external force is applied to the suspension tip 1602.

[0110] In some embodiments, the suspension lip 1608, suspension groove 1606, and suspension 1604 are sized and shaped such that the suspension member 1810 is preloaded when the suspension 1604 is received in the receiver 1202 and the tip connection feature is received in the suspension groove 1606. In some embodiments, this preload may be evident in a deflection of one or more of the suspension members 1810 when the suspension tip 1602 is in a stable position. In some embodiments, the suspension member 1810 can be preloaded such that a force of less than 6 ounces applied to the suspension tip 1602 does not result in any additional deflection of the suspension member 1810.

[0111] A side view of the suspension 1604 is shown in FIG. 18. The suspension can include a variety of shapes and sizes and can be made from a variety of materials. In some embodiments, the entire suspension 1604 can be made from a single material and / or type of material, and in some embodiments, different parts of the suspension 1604 can be made from different materials. In some embodiments, the suspension can be made from natural or synthetic materials. In some embodiments, the suspension 1604 can be made from a polymer, elastomer, or metal. In some embodiments, the suspension 1604 can include a polymer, such as polyamide. In some embodiments where the suspension 1604 thermally isolates the suspension tip 1602 from the cold plate 116, the suspension 1604 can be made from a polymer with low thermal conductivity. In some embodiments where the suspension 1604 closely thermally couples the suspension tip 1602 to the cold plate 116, the suspension 1604 can be made from a metal or other material with high thermal conductivity.

[0112] The suspension includes a top 1802 and a bottom 1803. The top 1802 of the suspension 1604 includes a central member 1804. The central member 1804 can include a variety of shapes and sizes. In some embodiments, the central member 1804 can include a cylindrically shaped member, which can include, for example, a circular cross-section. In some embodiments, and as depicted in FIGS. 16 and 19, the central member 1804 can be hollow and / or define a lumen extending therethrough.

[0113] In some embodiments, the central member 1804 can define a central receiver 1805. In some embodiments, the central receiver 1805 can be sized and / or shaped to receive a portion of the cold plate 116 when the suspension assembly tip 1600 is coupled to the cold plate 116. Specifically, in some embodiments, the central receiver 1805 can be configured to receive the distal protrusion 800 and prevent the distal protrusion 800 (specifically, the distal end 802 of the distal protrusion 800) from contacting the suspension tip 1602.

[0114] In some embodiments, the central member 1804 and the suspension 1604 can have a central axis 1806 that extends centrally through the suspension 1604 and through the top 1802 and bottom 1803 of the suspension 1604.

[0115] The suspension 1604 includes a suspension member array 1808 that can include a plurality of suspension members 1810. Each of the suspension members 1810 can include a variety of shapes and sizes and can be made from a variety of materials. In some embodiments, each of the suspension members 1810 can be elastic, allowing each suspension member 1810 to elastically deform and then return to its original position. In some embodiments, and as seen in FIG. 19 , each of the suspension members 1810 can include a cantilever beam having a proximal end 1902 connected to the central member 1804 and a distal end 1904 that engages the suspension lip 1608. In some embodiments, the cantilever beam can include a rectangular cross-section.

[0116] Each of the suspension members 1810 in the suspension member array 1808 can deflect toward the top 1802 of the suspension 1604 and / or toward the bottom 1803 of the suspension 1604. In some embodiments, each of the suspension members 1810 can deflect toward the top 1802 of the suspension 1604 and / or toward the bottom 1803 of the suspension 1604 by up to, for example, 1 mm, 2 mm, 3 mm, 4 mm, 5 mm, 6 mm, 7 mm, 8 mm, 9 mm, 10 mm, or up to any other or intermediate value. In some embodiments, the suspension members 1810 on one side of the suspension member array 1808 can flex toward the bottom 1803 and the suspension members 1810 on the opposite side of the suspension member array 1808 can flex in the opposite direction toward the top 1802 of the suspension 1604, or in the same direction but to a lesser extent, thereby providing a rocking motion to the suspension tip 1602.

[0117] The plurality of suspension members 1810 can be distributed circumferentially around the central member 1804 such that they are evenly distributed about the central axis 1806. In some embodiments, the suspension members 1810 can be spaced equidistantly about the central axis 1806 and can extend from the central member 1804 in a spoke-like manner. In some embodiments, some or all of the plurality of suspension members 1810 can lie generally in a common plane and / or extend in a direction perpendicular to the central axis 1806.

[0118] The suspension 1604 can include any desired number of suspension members 1810, including, for example, 4, 5, 6, 7, 8, 9, 10, 12, 14, 16, 18, 20, 30, 40, 50, 100, or any other or intermediate number of suspension members 1810. In some embodiments, the suspension 1604 can include, for example, more than 4 suspension members 1810, more than 6 suspension members 1810, more than 8 suspension members 1810, more than 10 suspension members 1810, more than 20 suspension members 1810, more than 30 suspension members 1810, more than 40 suspension members 1810, more than 60 suspension members 1810, more than 80 suspension members 1810, more than 100 suspension members 1810, or any other or intermediate number of suspension members 1810.

[0119] The suspension 1604 can include a linking member array 1812 including a plurality of linking members 1814. In some embodiments, each linking member 1814 can be configured to connect the suspension 1604 to the cold plate 116 and to the suspension tip 1602. The suspension 1604 can include any desired number of linking members 1814 in the linking member array 1812, including, for example, 4, 5, 6, 7, 8, 9, 10, 12, 14, 16, 18, 20, 30, 40, 50, 100, or any other or intermediate number of linking members 1814. In some embodiments, the suspension 1604 can include, for example, more than four linking members 1814, more than six linking members 1814, more than eight linking members 1814, more than ten linking members 1814, more than twenty linking members 1814, more than thirty linking members 1814, more than forty linking members 1814, more than sixty linking members 1814, more than eighty linking members 1814, more than one hundred linking members 1814, or any other or intermediate number of linking members 1814. In some embodiments, the linking member array 1812 can include the same number of linking members 1814 as the number of suspension members 1810 in the suspension member array 1808. In some embodiments, the linking member array 1812 can include a different number of linking members 1814 than the number of suspension members 1810 in the suspension member array 1808.

[0120] 19 , each of the linking members 1814 can include a proximal end 1906 connected to the central member 1804 and can extend downwardly and radially away to a distal end 1908. In some embodiments, the linking members 1814 can be distributed circumferentially around the central member 1804 such that they are uniformly distributed around the central axis 1806. In some embodiments, the linking members 1814 can be disposed equidistantly around the central axis 1806 and can extend from the central member 1804 in a spoke-like manner. In some embodiments, due to the downward and radially outward extension of the linking members 1814, the linking member array 1812 can be conical in shape, and specifically, can have a frusto-conical shape.

[0121] Each of the linking members 1814 can include a linking arm 1816 and a linking head 1818. As seen in FIG. 18 , the linking arm 1816 can connect at its proximal end to the central member 1804 and at its distal end to the linking head 1818. The linking head 1818 can include an external connector 1820 configured to connect with the suspension tip 1602, and specifically, to the suspension groove 1606 of the suspension tip 1602. The linking head 1818 can further include an internal connector 1822 configured to connect with the cold plate 116, and specifically, to the retention recess 814 of the cold plate 116.

[0122] In some embodiments, the external connector 1820 can include a flexible arm 1824 and an engagement head 1826. The engagement head 1826 of the external connector 1820 can be configured to engage with, and more specifically, to be received within, the suspension groove 1606 of the suspension tip 1602. The flexible arm 1824 can be configured to flex to facilitate engagement of the engagement head 1826 with the suspension groove 1606 of the suspension tip 1602.

[0123] In some embodiments, the internal connector 1822 can include a deflectable arm 1828 and an engagement head 1830. The engagement head 1830 of the internal connector 1822 can be configured to engage with the cold plate 116, specifically, to be received within the retention recess 814 of the cold plate 116. The deflectable arm 1828 can be configured to deflect to facilitate engagement of the engagement head 1830 with the cold plate 116 (specifically, the retention recess 814 of the cold plate 116).

[0124] 20, a schematic diagram of one embodiment of the chiller 211 is shown. The chiller 211 can include a coolant circulation system 2000, which can be coupled to the refrigeration unit 212 via a heat exchanger 2002. The coolant circulation system 2000 can be configured to circulate a coolant through the coolant circulation system 2000 (including through the hand piece 112). In some embodiments, the coolant can be a heat sink, and a cooler 230 in the hand piece 112 can transfer heat from the cold plate 116 to the heat sink.

[0125] In some embodiments, as depicted in FIG. 20, the refrigeration unit 212 can be configured to cool the refrigerant in the refrigerant circulation system 2000, and the heater 206 can be configured to heat the refrigerant in the refrigerant circulation system 2000. In some embodiments, the combination of the heater 206 and the refrigeration unit 212 can enable cooling of the refrigerant to a desired temperature range, specifically, can enable cooling of the refrigerant to a desired temperature range while reducing the need to change the cooling output of the refrigeration unit 212. In some embodiments, for example, the refrigeration unit 212 can have a longer life time if the output of the refrigeration unit 212 remains relatively constant. To enable control of the refrigerant temperature while maintaining a relatively constant output of the refrigeration unit 212, the heater 206 can heat the refrigerant. Thus, management of the temperature of the refrigerant can be performed by the heater 206 based in large part on temperature data collected from the temperature sensor 208.

[0126] The circulation system 2000 can include a coolant reservoir 2004, which can contain a coolant. In some embodiments, the level of the coolant in the coolant reservoir 2004 can be measured by a liquid sensor 218. If the coolant level measured by the liquid sensor 218 drops below a predetermined level, an error message or warning can be provided to a user, for example, via a graphical user interface (GUI) on the display 104 and / or via the speaker 238.

[0127] In some embodiments, the coolant pump 220 can circulate the coolant through the circulation system 2000. In some embodiments, this pump can provide further controlled cooling of the coolant provided to the handpiece 112. Specifically, if more cooling is desired, the rate at which the coolant is circulated can be increased and / or the temperature of the coolant can be decreased. Similarly, if less cooling is desired, the rate at which the coolant is circulated can be decreased and / or the temperature of the coolant can be increased.

[0128] 21 is a flow chart illustrating one embodiment of a process 2100 for delivering skin cooling treatment to a patient (more specifically, to an area of ​​the patient's skin). Process 2100 can be performed by cooling treatment system 100.

[0129] Process 2100 begins at block 2102, where a self-check is performed. In some embodiments, the self-check can be performed periodically, or, for example, when the cold treatment system 100 is turned on or awakened. In some embodiments, the self-check can check to determine whether coolant levels are satisfactory; whether the components of the cold treatment system 100 are functional; whether the handpiece 112 is present; and the like. The self-check can be performed by the controller 110. In some embodiments, the self-check can include determining the operation of the handpiece 112 and / or the components of the handpiece (including, for example, the motor 232, the temperature sensor 236, the speaker 238, and / or any other indicators (e.g., one or several LEDs, etc.), etc.) of the cold treatment system 100.

[0130] At block 2104, any errors triggered by the self-check may be indicated to the user. This may include controlling a GUI on the display 104 to provide a visual indication and / or visual identification of any errors to the user, and / or providing an audible indication of any errors to the user, for example via the speaker 238. If no errors are detected, the GUI may be controlled to display the image of FIG. 23, which indicates that the system is ready to accept the artifact 107.

[0131] At block 2106, an artifact 107 (e.g., a card, etc.) is accepted. In some embodiments, the artifact may be accepted by a physical feature associated with the reader 106. In some embodiments, for example, the reader may include a physical feature (e.g., a slot, etc.) configured to accept the artifact 107. In such embodiments, the artifact 107 may be accepted by this feature, and specifically may be accepted into the slot. In some embodiments, and instead of a physical artifact, a non-physical artifact may be accepted and / or read. In some embodiments, this may include accessing information contained within a digital artifact.

[0132] After the artifact 107 is accepted, it may be read, as shown in block 2108. In some embodiments, this may include reading data from the artifact 107. This may include, for example, powering features of the artifact 107 (e.g., the artifact's 107 microprocessor, etc.), querying the artifact 107 for information, and / or receiving data from the artifact 107. In some embodiments, reading data from the artifact may include determining a value of a count of available treatment cycles associated with the artifact. If it is determined that the artifact has at least one treatment cycle available, the process 2100 may proceed to block 2110. Alternatively, if it is determined that the artifact does not have any treatment cycles available, the lack of available treatment cycles may be indicated to the user and the process 2100 may end. This reading and determination may be performed by the reader 106.

[0133] Based on the information read from the artifact 107, which has at least one remaining treatment cycle in its count of available treatment cycles, in block 2110, a type of machine for the cooling treatment is identified. In some embodiments, this may include determining whether the data retrieved from the artifact identifies a type of cold treatment system 100 for performing the treatment. As previously discussed, some embodiments of the cold treatment system 100 may provide different cooling / temperature control of the cold plate 116, and thus a particular treatment may be provided via different embodiments of the cold treatment system 100. If the data identifies a machine for providing the cooling treatment, then it is determined whether the cold treatment system 100 that read the artifact 107 in block 2108 matches the machine type identified in the read data. If it is determined that the machine types do not match, then the process 2100 may end, and an indication of the end and a reason for the end may be provided to the user.

[0134] If it is determined that the machine type matches, process 2100 may proceed. At block 2112, treatment instructions may be identified in the data read from the artifact at block 2108. In some embodiments, this may include identifying treatment instructions stored on the artifact 107. These treatment instructions may include, for example, instructions for technical treatments, cryotherapy, and restorative treatments. In some embodiments where the treatment includes cryotherapy or restorative treatment, the treatment instructions may include at least one temperature profile that may identify multiple temperatures and associated times for maintaining each of the multiple temperatures.

[0135] One embodiment of a treatment profile 2200 is shown in Figure 22. As seen in Figure 22, the treatment profile 2200 identifies multiple temperatures and times associated with each of the temperatures. For example, the treatment profile 2200 may non-exclusively indicate a temperature of +20°C for a duration of 0 seconds, followed by a temperature of -4°C for a duration of 85 seconds for cryotherapy, followed by a temperature of +7°C for a duration of 15 seconds, followed by a temperature of +15°C for a duration of 1 second, followed by a temperature of +1°C for a duration of 195 seconds, followed by a temperature of +7°C for a duration of 5 seconds, followed by a temperature of +20°C for a duration of 600 seconds (dwell time), followed by a temperature of +15°C for a duration of 1 second, followed by a temperature of +1°C for a duration of 180 seconds, followed by a temperature of +7°C for a duration of 20 seconds, followed by a temperature of +10°C for a duration of 180 seconds, followed by a temperature of +10°C for a duration of 20 seconds, followed by a temperature of +20°C for a duration of 600 seconds (dwell time), followed by a temperature of +15°C for a duration of 1 second, followed by a temperature of +1°C for a duration of 180 seconds, followed by a temperature of +7°C for a duration of 20 seconds, followed by a temperature of +10 ... followed by a temperature of +15°C for a duration of 1 second, followed by a temperature of +1°C for a duration of 165 seconds, followed by a temperature of +7°C for a duration of 35 seconds, followed by a temperature of +15°C for a duration of 1 second, followed by a temperature of +20°C for a duration of 600 seconds, followed by a temperature of +15°C for a duration of 1 second, followed by a temperature of +1°C for a duration of 150 seconds, followed by a temperature of +7°C for a duration of 50 seconds, followed by a temperature of +20°C for a duration of 1 second, followed by a temperature of +1°C for a duration of 135 seconds, followed by a final temperature of 7°C for a duration of 15 seconds.

[0136] At block 2114, a GUI corresponding to the identified treatment is launched. In some embodiments, for example, this may include launching a GUI for the technical treatment when the identified treatment is a technical treatment, launching a GUI for the cryotherapy when the identified treatment is a cryotherapy, and launching a GUI for the restorative treatment when the identified treatment is a restorative treatment. FIGS. 24-28 depict an embodiment of an launched GUI associated with a restorative treatment, and FIGS. 28-29 depict an embodiment of an launched GUI associated with a cryotherapy. In some embodiments, the GUI may display information related to the identified treatment. For example, the GUI as depicted in FIG. 29 identifies two treatment profiles with different cooling rates and for providing the treatment. Specifically, FIG. 29 indicates that a cooling factor of 3.8 (which is a dimensionless indicator of the cooling rate) should be applied for a duration of 16 seconds, and that a cooling factor of 4 should also be applied for a duration of 16 seconds.

[0137] At block 2116, the treatment instructions are retrieved from the artifact 107. In some embodiments, this step may be performed as part of the reading of the artifact 107 performed at block 2108. Retrieving the treatment from the artifact 107 may include downloading information identifying the treatment from the card.

[0138] At block 2117, instructions are received from a user to provide a treatment and / or an indication is received from a user to provide a treatment. The indicator and / or instructions can be received via a user providing input, for example, via the display 104, via the controls 240 on the handpiece 112, and / or via detection of a change in skin contact conditions, for example, by cap touch 234, a temperature sensor, or a pressure sensor. In some embodiments, receiving an indication from a user to provide a treatment decrements the value of the artifact count for available treatment cycles. In some embodiments, starting a treatment decrements the value of the artifact count for available treatment cycles.

[0139] In block 2118, the next step in the treatment is identified. In some embodiments, this may be the first step in the treatment if the treatment has not yet been started. This next step may be identified from the downloaded treatment. The next step may be a freezing or freezing step, a cooling step, and / or a warming or rewarming step, in some embodiments. After the next step in the treatment is identified, the GUI is controlled to guide the user through performing the user action of the next step, as shown in block 2120. In some embodiments, the step of block 2120 may include multiple sub-steps that may be performed before, simultaneously with, and / or after one or some other of the steps shown in block 2122. For example, the step of block 2120 may include instructing the user to cool some of the patient's skin, which may be performed after block 2128 and / or block 2130, or in other words after the cold plate 116 achieves the desired temperature and after an indicator of the start of the treatment identified in the next step is received.

[0140] FIGURES 25-28 show actions to be taken by the user as part of an identified treatment step of a restorative treatment. This includes placing a tip 119 on the cold plate 116 as shown in FIGURE 25. This may include an indication of which tip 119 to place on the cold plate 116. Thus, the GUI of FIGURE 25 indicates that a smooth tip 120 should be connected to the cold plate 116. FIGURE 26 shows that a button 700 on the handpiece 112 should be pressed. This may be pressed upon completion of other user actions associated with the identified step.

[0141] 27 and 28 are depictions of a GUI showing actions to be performed by a user with the hand piece 112. FIG. 27 shows where and how a user should apply the treatment tip 119 to perform a treatment. FIG. 27 further includes a countdown timer 2700, an end icon 2702, and a forward icon 2704, where the countdown timer 2700 can indicate the amount of time to provide the action and / or treatment shown on the GUI, the end icon 2702 can be operated to end the treatment, and the forward icon 2704 can be operated to advance to the next action in the treatment step. In some embodiments, the treatment can further be terminated via user input received via the hand piece 112 (specifically, via the button 700 of the hand piece 112) and / or via detection of a change in skin contact conditions, such as, for example, by the cap touch 234, a temperature sensor, or a pressure sensor. In some embodiments, and as discussed with respect to block 2130, the countdown timer may begin its countdown upon detecting a treatment trigger and / or receiving an indication to begin performing an associated treatment step. In some embodiments, this may include receiving a signal indicating the start of treatment and / or detecting an event indicating the start of treatment. This may include detecting a temperature change of the cold plate and / or treatment tip indicative of contact with the patient's skin, for example, upon detecting a user pressing a button 700 on the handpiece 112 by a capacitive touch sensor 234 that detects contact between the cold plate and / or treatment tip 119 and the patient's skin.

[0142] FIG. 28 is a depiction of a GUI that prompts a user to provide a dwell time. As seen in FIG. 28, the GUI includes a countdown timer 2700 that indicates the amount of time remaining in the dwell time. In some embodiments, and as discussed with respect to block 2130, the countdown timer can begin its countdown upon detection of a therapy trigger and / or upon receiving an indication to begin performance of an associated therapy step. Thus, for example, the countdown timer can begin its countdown upon detection of a user pressing a button 700 on the handpiece 112 and / or via detection of a change in skin contact conditions, such as by cap touch 234, a temperature sensor, or a pressure sensor.

[0143] 30-32 are depictions of a GUI showing actions to be performed by a user with the handpiece 112 as part of a cryotherapy treatment. FIG. 30 shows that the user should press the button 700. In some embodiments, pressing this button can initiate cooling of the cold plate 116 to a desired cold plate temperature. FIG. 31 shows that the user should apply the cold plate to the patient's skin. FIG. 31 further includes a countdown timer 2700. FIG. 32 shows the cold plate 116 being applied to the patient's skin, with the countdown timer 2700 shown counting down the time until the completion of the treatment step.

[0144] In some embodiments, guiding the user through performing a next step user action can include, for example, instructing the user to identify at least one topical agent and, optionally, to apply the topical agent to the area of ​​the patient's skin using the handpiece tip (or a textured or smooth tip applied to the handpiece for dispensing the topical agent). In some embodiments, this can further include instructing the user to cool the area of ​​the patient's skin via the handpiece 112.

[0145] In some embodiments, instructing the user to cool the area of ​​the patient's skin via the hand piece 112 can include instructing the user to contact the area of ​​the patient's skin with the cold plate 116 and instructing the user to press the button 700 to indicate the start of delivery of the identified next step treatment. In some embodiments, instructing the user to cool the area of ​​the patient's skin via the hand piece 112 can include instructing the user to connect a treatment tip 119 to the cold plate 116 of the hand piece 112, to contact the area of ​​the patient's skin with the treatment tip 119 connected to the cold plate 116, and to press the button 700 to indicate the start of delivery of the identified next step treatment. In some embodiments, the treatment tip 119 can be one of a smooth tip 120 and a textured tip 122. In some embodiments, the GUI can be controlled to track the duration of the treatment step, for example, via a countdown timer. In some embodiments, the countdown timer can indicate the remaining duration of time that the hand piece 112 should be used to cool the patient's skin or the remaining duration of dwell time that the topical agent should be allowed to rest on the patient's skin without interaction with the hand piece 112.

[0146] In some embodiments, controlling the GUI to guide the user through performing the next step user action can include, for example, instructing the user to perform a cleansing step (also referred to herein as a purifying step). In some embodiments, when instructing the user to perform the cleansing step user action, the GUI can be controlled to instruct the user to massage the cleanser into the patient's skin and / or into the patient's face, and to remove the cleanser with gauze and / or a towel (which can be, for example, water saturated or wet).

[0147] In some embodiments, controlling the GUI to guide the user through performing the next step user action can include, for example, instructing the user to perform a freezing step (also referred to herein as intensive cooling). In some embodiments, the freezing step can include cooling the cold plate 116 to one or several temperatures below freezing. For example, this can include, for example, a temperature of -30°C to approximately 10°C, or, for example, a temperature of -10°C to approximately 10°C, etc. In some embodiments, the user can be instructed to hold the cold plate 116 over the portion of skin being treated for a desired amount of time (including, for example, less than 1 minute, between 1 minute and 5 minutes, between 1 minute and 10 minutes, or between 1 minute and 20 minutes, etc.). In some embodiments, when instructing the user to perform the user actions of the freezing step, the GUI can be controlled to instruct the user to access the spot, insert the freeze card, select a temperature profile, apply a few drops of gel, such as HYDRO GEL, directly onto the treatment area, spread the gel with a finger, press button 700 to begin pre-cooling, place the cold plate 116 over the treatment area upon completion of pre-cooling, hold the cold plate 116 over the treatment area until treatment is complete, clean the treatment area, and clean the cold plate 116.

[0148] In some embodiments, controlling the GUI to guide the user through performing the next step user action can include instructing the user to perform a stripping step (also referred to herein as a loosening step). In some embodiments, the stripping step can include cooling the cold plate 116 to a desired temperature, which can be, for example, between −4° C. and approximately 4° C., for example, between −2° C. and approximately 2° C., or approximately 1° C., etc. In some embodiments, the user can be instructed to apply cooling with the hand piece 112 onto the portion of skin being treated for a desired amount of time (including, for example, between 60 seconds and 300 seconds, between 100 seconds and 240 seconds, between 150 seconds and 220 seconds, or approximately 195 seconds, etc.). In some embodiments, the stripping step can include instructing the user to allow a dwell time, which can be a time during which the topical agent is allowed to soak into the patient's skin and during which the hand piece 112 is not applied to the patient's skin. The dwell time can be, for example, between 120 seconds and 1200 seconds, between 240 seconds and 1000 seconds, between 400 seconds and 800 seconds, or approximately 600 seconds, etc. The ablation step can be performed by a smooth tip 120.In some embodiments, when instructing the user to perform the user actions of the peeling step, the GUI can be controlled to instruct the user, for example, to insert the Rejuvenation card, to attach the tip 119 (e.g., smooth tip 120, etc.) to the cold plate 116, to apply a small amount of the agent (e.g., PEEL, etc.) onto the area of ​​skin being treated (e.g., onto the forehead and / or cheeks and / or chin, etc.), to press the button 700 on the hand piece 112 to start, to use the hand piece 112 to spread the agent onto the skin, to leave the agent on the skin for a predetermined period of time (e.g., 10 minutes, etc.), to remove the agent from the skin with a wet towel or gauze, and to clean the tip 119.

[0149] In some embodiments, controlling the GUI to guide the user through performing the next step user action can include, for example, instructing the user to perform an abrasion step (also referred to herein as a removal step). In some embodiments, the abrasion step can include cooling the cold plate 116 to a desired temperature, which can be, for example, between -4°C and approximately 4°C, for example, between -2°C and approximately 2°C, or approximately 1°C, etc. In some embodiments, the user can be instructed to apply cooling with the hand piece 112 onto the portion of skin being treated for a desired amount of time (including, for example, between 60 seconds and 300 seconds, between 100 seconds and 240 seconds, between 150 seconds and 220 seconds, or approximately 180 seconds, etc.). In some embodiments, the abrasion step can be performed by the textured tip 122. In some embodiments, when instructing the user to perform the user actions of the abrasion step, the GUI can be controlled to instruct the user to attach the tip 119 (e.g., textured tip 122, etc.) to the cold plate 116, to apply a topical agent (e.g., MIST, etc.) onto the area of ​​skin to be treated (e.g., onto the forehead and / or cheeks and / or chin, etc.), to press the button 700 on the handpiece 112 to start treatment, to use long strokes for each section of skin while holding the skin taut and not going through the same area more than twice, to spray additional topical agent onto the skin as needed throughout the cycle, to clean the skin being treated with a wet gauze or towel after completion of the cycle, to spray additional topical agent onto the skin, and to remove the tip 119 from the cold plate 116.

[0150] In some embodiments, controlling the GUI to guide the user through performing the next step user action can include, for example, instructing the user to perform a restore step (also referred to herein as a settling step). In some embodiments, the settling step can include cooling the cold plate 116 to a desired temperature, which can be, for example, between −4° C. and approximately 4° C., for example, between −2° C. and approximately 2° C., or approximately 1° C., etc. In some embodiments, the user can be instructed to apply cooling with the hand piece 112 onto the portion of skin being treated for a desired amount of time (including, for example, between 60 seconds and 300 seconds, between 100 seconds and 240 seconds, between 150 seconds and 200 seconds, or approximately 165 seconds, etc.). In some embodiments, the settling step can include instructing the user to allow a dwell time, which can be a time during which the topical agent is allowed to soak into the patient's skin and during which the hand piece 112 is not applied to the patient's skin. The dwell time can be, for example, between 120 seconds and 1200 seconds, between 240 seconds and 1000 seconds, between 400 seconds and 800 seconds, or approximately 600 seconds, etc. In some embodiments, the settling step can be performed by a smooth tip 120.In some embodiments, when instructing the user to perform the user actions of the calming step, the GUI can be controlled to instruct the user to attach the tip 119 (e.g., the first tip 120, etc.) to the cold plate 116, to apply the topical agent (e.g., MASK, etc.) onto the skin to be treated (e.g., onto the forehead and / or cheeks and / or chin, etc.), to press the button 700 on the hand piece 112 to start, to massage the topical agent into the skin with the hand piece 112, to spray additional topical agent onto the skin upon completion of the massage, to leave the topical agent on the skin for a predetermined period of time (e.g., 10 minutes, etc.), to remove the topical agent from the skin with a wet towel or gauze, and to clean the tip 119.

[0151] In some embodiments, controlling the GUI to guide the user through performing the next step user action can include, for example, instructing the user to perform a refresh step (also referred to herein as a protection step). In some embodiments, the refresh step can include cooling the cold plate 116 to a desired temperature, which can be, for example, between -4°C and approximately 4°C, for example, between -2°C and approximately 2°C, or approximately 1°C, etc. In some embodiments, the user can be instructed to apply cooling via the hand piece 112 onto the portion of skin being treated for a desired amount of time (including, for example, between 60 seconds and 300 seconds, between 100 seconds and 240 seconds, between 130 seconds and 180 seconds, or approximately 150 seconds, etc.). In some embodiments, the protection step can be performed by the smooth tip 120. In some embodiments, when instructing the user to perform a protective step user action, the GUI can be controlled to instruct the user to apply the topical agent (e.g., SERUM, etc.) directly onto the skin to be treated (e.g., the forehead and / or cheeks and / or chin, etc.), to press button 700 on handpiece 112 to start, to massage the topical agent into the skin with handpiece 112 having tip 119 (e.g., smooth tip 120, etc.), and to leave the topical agent on the skin after massaging and while cleaning tip 119.

[0152] In some embodiments, controlling the GUI to guide the user through performing the next step user action can include, for example, instructing the user to perform a glow step (also referred to herein as a protect step). In some embodiments, the glow step can include cooling the cold plate 116 to a desired temperature, which can be, for example, between -4°C and approximately 4°C, for example, between -2°C and approximately 2°C, or approximately 1°C, etc. In some embodiments, the user can be instructed to apply cooling with the hand piece 112 onto the portion of skin being treated for a desired amount of time (including, for example, between 60 seconds and 300 seconds, between 100 seconds and 240 seconds, between 120 seconds and 150 seconds, or approximately 135 seconds, etc.). In some embodiments, the glow step can be performed by the smooth tip 120. In some embodiments, when instructing the user to perform the user actions of the Glow step, the GUI can be controlled to instruct the user to apply the topical agent (e.g., MOISTURIZER, etc.) onto the skin to be treated (e.g., the forehead and / or cheeks and / or chin, etc.), to press button 700 on handpiece 112 to start, to massage the topical agent into the skin with handpiece 112 containing a tip (e.g., smooth tip 120, etc.), to massage any remaining topical agent into the skin with a finger, and to remove and discard tip 119.

[0153] In step 2122, any set temperature associated with the next step is identified. Thus, if the next step includes a temperature-related therapy (e.g., cooling and / or cryotherapy, etc.), the temperature associated with the identified next step of that therapy is identified. This temperature may be identified from the temperature profile.

[0154] In optional step 2123, one or more topical agents 132 may be applied to the skin to be treated. This may involve removing one or more topical agents 132 from the case 130 and then applying these one or more topical agents 132 to the skin to be treated. This step may be performed by a user of the cooling therapy system 100.

[0155] After the set point temperature for the identified step is identified, the temperature of the cold plate may be set to the identified set point temperature. In embodiments where the identified step of block 2118 corresponds to a first temperature identified in the temperature profile, the temperature of the cold plate may be set to that first temperature identified in the freezing profile. In some embodiments, the temperature of the cold plate may be set via the steps of blocks 2124 and 2126. In block 2124, the chiller 211 is controlled to cool the coolant therein to within a target range. In some embodiments, this may include controlling the refrigeration unit 212 and / or the heat load 206 to adjust the temperature of the coolant such that the temperature of the coolant is within a desired range.

[0156] In some embodiments, controlling the chiller 211 further includes controlling the pump 220 to control the circulation of coolant through the chiller 211 and through the hand piece 112. In some embodiments, controlling the pump 220 can result in the circulation of coolant through the hand piece 112.

[0157] At block 2126, the cooler 230 is controlled to cool the cold plate 116 to a desired cold plate temperature. In some embodiments, the cooler 230, which may include a thermoelectric cooler, may cool the cold plate 116 by transferring thermal energy from the cold plate 116 to a coolant circulating through the handpiece 112. In some embodiments, this heat transfer, and therefore the temperature of the cold plate 116, may be regulated according to information received from a temperature sensor 236, which in some embodiments senses the temperature of the cold plate 116.

[0158] Once the cold plate 116 achieves the desired cold plate temperature, an indication is provided that treatment is ready, in block 2128. In some embodiments, this may be indicated by the display 104, and in particular, via a GUI viewable on the display 104.

[0159] Treatment tracking begins at block 2130 upon detecting an input indicating and / or triggering the start of treatment. In some embodiments, this indication and / or triggering of the start of treatment can include receiving an input via pressing a button 700 on the hand piece 112, detecting a pressing of a button 700 on the hand piece, via the display 104, via the controls 240 on the hand piece 112, and / or via detecting a change in skin contact conditions, such as by cap touch 234, a temperature sensor, or a pressure sensor. In some embodiments, treatment tracking can include initiating a timer (also referred to herein as a countdown timer) indicating a desired amount of time for performing the identified next step. In some embodiments, treatment tracking can include controlling a GUI to display a countdown timer (such as, for example, that shown in FIG. 32 by timer 2700) upon receiving an indication of the start of treatment delivery as in block 2128.

[0160] Once a treatment step is completed, as determined by passing a desired amount of time associated with the step identified in block 2118, an indication of the completion of the step is provided to the user. In some embodiments, this indication can include a visual indication provided by a GUI and / or one or more LEDs, and in some embodiments, this indication can include a tactile and / or audible indication, for example, via the generation of vibrations in the handpiece 112 by the motor 232 and / or via the generation of sounds by the speaker 238.

[0161] At block 2134, the process 2100 determines whether there are any treatment steps remaining. If there are, the process 2100 returns to block 2118 and proceeds as outlined above. If there are no treatment steps remaining, the process 2100 proceeds to block 2136 where treatment completion is signaled. This treatment completion signal can be signaled via one or more GUIs, one or more LEDs, the motor 232, and the speaker 238.

[0162] In some embodiments, the process 2100 can be terminated upon receiving a termination request, as shown at block 2140. The termination request can be received, for example, from a user and / or generated by the cooling therapy system 100. In some embodiments, for example, the termination request can be generated by the controller 110 and / or the handpiece controller 114 when the sensed temperature is outside of an acceptable range and / or falls above or below a temperature threshold, or when the difference in temperature as measured by two or more sensors exceeds a limit value. In some embodiments, the temperature can be the temperature of the cold plate 116, the temperature of the chiller 211 component of the chiller 211, and / or the temperature of the cooler 230. In some embodiments, for example, the termination request can be generated if the cold plate 116 is too cold or too hot. In some embodiments, the termination request can be generated in response to an indication from the cap touch 234 that the cold plate 116 has been removed from the patient's skin and / or is no longer in contact with the patient's skin.

[0163] After the termination request is received and / or generated, the therapy is canceled at block 2142. In some embodiments, canceling the therapy may include controlling the chiller 211 and / or the cooler 230 to discontinue cooling and / or heating of the cold plate 116. In embodiments in which the cold plate 116 is cooling when the termination request is received, canceling the therapy may include controlling the chiller 211 and / or the cooler 230 to rewarm the cold plate 116.

[0164] Performing process 2100 may improve one or several attributes of a patient's skin. Referring now to FIG. 33, there is shown a graph 3300 depicting the measured improvement of a patient's skin following treatment according to process 2100. As can be seen in graph 3300, several of the attributes of a patient's skin may improve following treatment according to process 2100. These may include, for example, the appearance of fine lines and / or wrinkles, skin clarity and / or brightness, tactile and / or visual roughness of the skin, evenness of skin tone including redness and / or hyperpigmentation, and / or the overall appearance of the skin.

[0165] 34, there are shown before and after photographs 3402, 3404 depicting the improvement in a patient's skin after undergoing treatment with process 2100. Comparing a first photograph 3402 taken before treatment with a second photograph 3404 taken approximately 8 weeks after undergoing treatment with process 2100, the improvement in the patient's skin can be seen.

[0166] This description should not be construed as implying any particular order or arrangement between the various steps or elements, unless the order of the individual steps or arrangement of the elements is explicitly described. Different arrangements of the components depicted in the drawings or described above, as well as components and steps not shown or described, are possible. Similarly, some features and subcombinations are useful and can be used without reference to other features and subcombinations. The embodiments of the invention have been described for illustrative purposes and not for limiting purposes, and alternative embodiments will become apparent to the reader of this patent. Thus, the invention is not limited to the embodiments described above or depicted in the drawings, and various embodiments and modifications can be made without departing from the scope of the following claims. [Explanation of symbols]

[0167] 100 Cooling Therapy System 102 Main body, housing, console 103 Boom 104 Display 106 Leader 107 Artifacts 108 Single Board Computers ("SBC") 110 Controller 111 Cords, cables 112 Handpiece 114 Hand Controller 116 Cold plate, handpiece tip, freezing tip, freezing tip 118 cases 119 Tip 120 Smooth Tip 122 Textured Tip 124 Identifier 130 cases 132 External preparations 202 USB chip 204 Power supply 206 Power Entry, Heat Load 208 Temperature Sensor 210 Driver 211 Chiller 212 Refrigeration Unit 214 Fan 216 Temperature Sensor 218 Liquid Sensor 220 Pump, coolant pump Panel 222 224 USB 226 Antenna 228 Handpiece Board 230 Cooler 232 Motor 234 Capacitive Touch Sensor Electronics, CapTouch 236 Temperature Sensor 238 Speakers 240 Input features, control section 300 Retention Receptacle 302 Handle 400 Mounting Bracket 600 Wheeled Cart 602 wheels 604 Base 606 Housing 608 Vertical support 700 Input Features, Buttons 702 Retention Connector 800 Distal protrusion 801 axis 802 Distal end 804 Proximal end 806 Camming Surface 808 Distal end 810 Smoothing Features 812 Proximal end 814 Retention recess 816 Axial groove 1000 Housing, Outer Housing 1002 Contact surface 1004 Base 1006 Recess 1200 Opening 1202 Reception Department 1204 Mating Surface 1206 Retention Features 1208 O-ring 1210 Recess 1300 Outer Housing 1302 Contact surfaces 1304 Base 1306 Recess 1600 Suspension assembly tip 1602 Suspension tip 1604 Suspension 1606 Retention groove 1608 Suspension Lip 1620 Arrow 1702 Internal wall 1802 Top 1803 Bottom 1804 Central member 1805 Central Receptacle 1806 Center axis 1808 Suspension member array 1810 Suspension parts 1812 Connecting member array 1814 Connecting member 1816 Connecting Arm 1818 Connecting Head 1820 External Connector 1822 Internal Connector 1824 Flex Arm 1826 Engagement Head 1828 Flex Arm 1830 Engagement Head 1902 Proximal end 1904 Distal end 1906 Proximal end 1908 Distal end 2000 Coolant Circulation System 2002 heat exchanger 2004 Coolant Reservoir 2200 Treatment Profile 2700 Countdown Timer 2702 Exit Icon 2704 Progress Icon 3300 Graph 3402 The first photo taken before treatment 3404 A second photograph taken approximately 8 weeks after treatment.

Claims

1. 1. A system for delivering skin cooling therapy to an area of ​​a patient's skin, comprising: a card reader, a display, a chiller positioned within a housing, a handpiece, and a processor, the handpiece including a chiller flexibly coupled to the housing and configured to cool a cold plate of the handpiece, the processor comprising: configured to identify treatment instructions stored in a card accepted into the card reader, the treatment instructions including at least one temperature profile, the at least one temperature profile identifying a plurality of temperatures and associated times for maintaining each of the plurality of temperatures; configured to launch a graphical user interface (GUI) corresponding to the identified treatment instructions; configured to identify a step among a plurality of steps in the identified treatment instructions, each step being associated with a treatment; configured to control the GUI to guide a user through performing a user action of the step in the identified treatment instructions; configured to set the temperature of the cold plate to a first temperature of the temperature profile; and The system is configured to control the GUI to display a countdown timer upon receiving an indication of initiation of delivery of the treatment for the identified step.

2. 2. The system of claim 1, wherein the steps include a freezing step, a second step includes a cooling step, a third step includes a dwell step, and a fourth step includes a rewarming step.

3. The processor is configured to: Identifying at least one topical agent; directing application of the topical agent to the area of ​​skin of the patient; instructing the user to cool the area of ​​the patient's skin via the handpiece; The system of claim 1 , further configured to control the GUI to guide the user to:

4. Instructing the user to cool the area of ​​the patient's skin via the handpiece includes: contacting the area of ​​the patient's skin with the cold plate; and Pressing a button to indicate the start of delivery of said treatment; The system of claim 3 further comprising the step of prompting the user.

5. Instructing the user to cool the area of ​​the patient's skin via the handpiece includes: connecting a treatment tip, the treatment tip including at least one of a smooth tip and a textured tip, to the cold plate of the handpiece; contacting the area of ​​the patient's skin with the treatment tip connected to the cold plate; and Pressing a button to indicate the start of delivery of said treatment; The system of claim 3 further comprising the step of prompting the user.

6. instructing the user to cool the area of ​​the patient's skin via the handpiece includes instructing the user to contact the area of ​​the patient's skin with the cold plate of the handpiece; The processor may further comprise: configured to detect a therapy trigger indicative of contact between the cold plate and the area of ​​the patient's skin; and The system of claim 3 , configured to begin tracking the therapy upon detecting a therapy trigger.

7. The cold plate is a distal projection; and a camming surface extending proximally and radially away from the proximal end of the distal projection; a retention recess connected to a proximal end of the camming surface; The system of claim 1 , comprising:

8. The method further comprising the steps of: An outer housing; a retention feature positioned within the outer housing, the retention feature configured to be retained within the retention recess, thereby connecting the treatment tip to the cold plate; The system of claim 7 , comprising:

9. Setting the temperature of the cold plate to a first temperature of the temperature profile comprises: controlling the chiller to cool the coolant to a coolant temperature within a target range; circulating the coolant through the handpiece; controlling the chiller in the handpiece to cool the cold plate to a desired cold plate temperature; The system of claim 1 , comprising:

10. The system of claim 9, wherein the cooler includes a thermoelectric cooler configured to transfer heat from the cold plate to the coolant circulating through the handpiece.

11. The chiller comprises: A coolant circulation system; A heat exchanger; a refrigeration unit connected to the coolant circulation system via heat exchange; The system of claim 10 , comprising:

12. 12. The system of claim 11, wherein the refrigeration unit is configured to cool the coolant in the coolant circulation system, and the chiller further includes a heating unit configured to heat the coolant in the coolant circulation system.

13. The system of claim 1 , wherein the processor is configured to receive a termination request to cancel the therapy, the termination request being received from the user.

14. 10. The system of claim 1, wherein the processor is configured to generate a termination request to cancel the therapy, the termination request being generated by a processor of the cooling therapy system in response to a detected temperature.

15. The system of claim 14 , wherein the detected temperature includes at least one of: a temperature of the cold plate; a temperature of the chiller; or a temperature of the cooler.

16. 15. The system of claim 14, wherein canceling the therapy comprises controlling the chiller to rewarm the cold plate.

17. 15. The system of claim 14, wherein canceling the therapy comprises heating the cold plate, and wherein heating the cold plate comprises controlling at least one of the chiller and the cooler to heat the cold plate.

18. The processor: configured to determine a value of a count of available treatment cycles associated with the card; configured to receive instructions from a user for providing the treatment; configured to initiate at least one therapy when the value indicates that the therapy is available; and The system of claim 1 , configured to decrement the value of the count of available treatment cycles when starting the treatment.

Images