A novel delivery system for vitamin C.

Abstract

The present invention relates to a novel delivery system for vitamin C (also known as ascorbic acid and ascorbate salts) for release in the large intestine. These nutritional ingredients are beneficial for intestinal and metabolic health in monogastric animals (such as pigs and poultry, as well as fish), and particularly in humans.

Description

Detailed Description of the Invention

[0001] The present invention relates to a novel delivery system for vitamin C (also known as ascorbic acid and ascorbate salts) for release in the large intestine. These nutritional ingredients are beneficial for intestinal and metabolic health in monogastric animals (such as pigs and poultry, as well as fish), and particularly in humans.

[0002] In many cases, it is desirable for pharmaceutical and nutraceutical dosage units to pass through the stomach unchanged and release their contents upon reaching the intestine. This controlled release may be particularly desirable when ingredients of the dosage unit are unstable in the acidic environment of the stomach and it is intended that the ingredients be released in the slightly alkaline conditions of the digestive tract beyond the stomach.

[0003] The novel formulation according to the present invention allows for the release of vitamin C in the large intestine.

[0004] Thus, the present invention provides (a) a solid core containing vitamin C; (b) shellac and / or shellac ammonium salts; At least one alginate having a viscosity of 10 to 800 mPas (10% aqueous solution at 20 ° C), and at least one plasticizer a coating comprising: The present invention relates to a single coated delivery system (DS) consisting of:

[0005] The novel delivery system is a single coated formulation, which means that the inner part (core) of the formulation is covered by a single layer. The novel delivery system does not include another additional layer.

[0006] Typically, a single coated delivery system according to the present invention comprises: 60-95 weight percent (wt-%) (preferably 70-90 wt-%) of the core based on the total weight of the single coated delivery system; A coating layer of 5 to 40 wt-% (preferably 10 to 30 wt-%) based on the total weight of the single coated delivery system; Includes.

[0007] Typically and preferably, the single coated delivery system comprises: 60-95 wt-% of the core based on the total weight of the single coated delivery system; A coating layer of 5 to 40 wt-% based on the total weight of the single coated delivery system; It consists of:

[0008] More preferably, the single coated delivery system comprises: 70-90 wt-% of the core based on the total weight of the single coated delivery system; A coating layer of 10-30 wt-% based on the total weight of the single coated delivery system; It consists of:

[0009] All percentages for single coated delivery systems typically add up to 100.

[0010] Thus, the present invention provides a single coated delivery system comprising 60-95 wt-% of a core based on the total weight of the system; A coating layer of 5 to 40 wt-% based on the total weight of the single coated delivery system; The present invention relates to a single coated delivery system (DS1), which is a coated delivery system (DS) comprising:

[0011] Thus, the present invention provides a single coated delivery system comprising 70-90 wt-% of a core based on the total weight of the system; A coating layer of 10-30 wt-% based on the total weight of the single coated delivery system; The present invention relates to a single coated delivery system (DS1') which is a coated delivery system (DS) comprising:

[0012] Thus, the present invention provides a single coated delivery system comprising 60-95 wt-% of a core based on the total weight of the system; The present invention relates to a single coated delivery system (DS1''), which is a coated delivery system (DS) consisting of a coating layer of 5 to 40 wt-% based on the total weight of the single coated delivery system.

[0013] Thus, the present invention provides a single coated delivery system comprising 70-90 wt-% of a core based on the total weight of the system; The present invention relates to a single coated delivery system (DS1'''), which is a coated delivery system (DS) consisting of a coating layer of 10 to 30 wt-% based on the total weight of the single coated delivery system.

[0014] The coating of the single coated delivery system according to the present invention completely covers the solid core. Ideally, the coating layer has a (more or less) uniform thickness when applied over the solid core.

[0015] Usually, the thickness of the coating layer is at least 5 μm and not more than 50 μm, and preferably, the thickness of the coating layer is 5 μm to 50 μm.

[0016] Thus, the present invention relates to a single coated delivery system (DS2) which is a coated delivery system (DS), (DS1), (DS1'), (DS1'') or (DS1''') in which the thickness of the coating layer (applied on the core) is at least 5 μm and not more than 50 μm.

[0017] Thus, the present invention relates to a single coated delivery system (DS2') which is a coated delivery system (DS), (DS1), (DS1'), (DS1'') or (DS1''') having a coating layer thickness of 5 μm to 50 μm.

[0018] The solid core of the single coated delivery system of the present invention contains vitamin C.

[0019] The term "core" in the context of the present invention normally refers to a particle made by any commonly known and used technique (spray-drying, spray-cooling, spray-granulation, spray-chilling, agglomeration, extrusion-spheronization, pelletization, etc.) and containing at least one active ingredient.

[0020] Vitamin C can be chemically produced or isolated from natural sources (mainly fruits and vegetables). For the formulation according to the present invention, the source is not essential. Any vitamin C (even mixtures from various sources) can be used.

[0021] The core contains up to 100 wt-% vitamin C based on the total weight of the core.

[0022] Thus, the present invention relates to a single coated delivery system (DS3) in which the core is a coated delivery system (DS), (DS1), (DS1'), (DS1''), (DS1''') or (DS2) comprising up to 100 wt-% vitamin C based on the total weight of the core.

[0023] Additionally, the core may contain any commonly known auxiliary substances that are normally used for the preparation of the core.

[0024] Such adjuvants are, for example, carriers (such as cellulose, maltodextrin, starch or lactose); binders (such as gel-forming agents like pectin, hydroxypropylmethylcellulose, xanthan gum, gellan gum); humectants (such as glycerin, sorbitol, polyethylene glycol, triethyl citrate); dyes; flavorings; fillers and buffers.

[0025] Such adjuvants are typically present in an amount of up to 80 wt-% relative to the total weight of the core (typically 10-60 wt-%, preferably 10-40 wt-% relative to the total weight of the core).

[0026] Thus, the present invention relates to a single coated delivery system (DS4) which is a coated delivery system (DS), (DS1), (DS1'), (DS1''), (DS1'''), (DS2) or (DS3) whose core comprises at least one auxiliary agent.

[0027] Thus, the present invention relates to a single coated delivery system (DS4') which is a coated delivery system (DS4) in which at least one auxiliary agent is selected from the group consisting of carriers (such as cellulose, maltodextrin, starch or lactose); binders (such as gel-forming agents like pectin, hydroxypropylmethylcellulose, xanthan gum, gellan gum); humectants (such as glycerin, sorbitol, polyethylene glycol, triethyl citrate); dyes; fragrances; fillers and buffers.

[0028] Thus, the present invention relates to a single coated delivery system (DS4'') in which the core is a coated delivery system (DS4) or (DS4') comprising up to 80 wt-% of at least one auxiliary agent relative to the total weight of the core.

[0029] Thus, the present invention relates to a single coated delivery system (DS4''') in which the core is a coated delivery system (DS4) or (DS4') comprising 10-60 wt-% of at least one auxiliary agent relative to the total weight of the core.

[0030] Thus, the present invention relates to a single coated delivery system (DS4'''') in which the core is a coated delivery system (DS4) or (DS4') comprising 10-40 wt-% of at least one auxiliary agent relative to the total weight of the core.

[0031] The core of the single coated delivery system according to the present invention may be made by any commonly known process (spray drying, spray-cooling, spray granulation, spray-chilling, agglomeration, extrusion-spheronization, pelletization, etc.).

[0032] The shape of the core is not an essential feature of the present invention. The shape can be spherical or any other form (even a mixture of shapes). Typically and preferably, the particles are spherical.

[0033] The size of the core as well as the size of the single coated delivery system according to the present invention are not essential characteristics of the present invention.

[0034] A suitable size for the single coated delivery system according to the present invention is between 100 and 2300 μm (preferably between 300 and 2000 μm, more preferably between 500 and 1400 μm); the size is determined by the widest diameter of the particle and is measured by commonly known methods (such as laser diffraction or sieve analysis).

[0035] As described above, the thickness of the coating layer is 5 μm to 50 μm.

[0036] All particle sizes are determined by laser diffraction techniques using a "Mastersizer 3000" from Malvern Instruments Ltd., UK. Further information on this particle size characterization method can be found, for example, in "Basic principles of particle size analytics", Dr Alan Rawle, Malvern Instruments Limited, Enigma Business Part, Grovewood Road, Malvern, Worcestershire, WR14 1XZ, UK, and in "Manual of Malvern particle size analyzer". Particular reference is made to the user manual number MAN 0096, Issue 1.0, Nov. 1994. Unless otherwise stated, all references to particle size are to the Dv90 value (volume diameter, 90% of the population falls below this point and 10% falls above this point) determined by laser diffraction. Particle size may be determined in dry form.

[0037] Thus, the present invention relates to a coated delivery system (DS), (DS1), (DS1'), (DS1'', (DS1'"), (DS2), (DS3), (DS4), (DS4'), (DS4'', (DS4''') or (DS4'''') having a size of 100 to 2300 μm.

[0038] Thus, the present invention relates to a coated delivery system (DS), (DS1), (DS1'), (DS1'', (DS1'"), (DS2), (DS3), (DS4), (DS4'), (DS4'', (DS4''') or (DS4'''') having a size of 300-2000 μm.

[0039] Thus, the present invention relates to a single coated delivery system (DS5'') which is a coated delivery system (DS), (DS1), (DS1'), (DS1'', (DS1''), (DS2), (DS3), (DS4), (DS4'), (DS4'', (DS4''') or (DS4'''') having a size of 500-1400 μm.

[0040] The coating of the single coated delivery system according to the present invention comprises shellac and / or at least one ammonium shellac salt, at least one alginate salt having a viscosity of 10-800 mPas (10% aqueous solution at 20° C.), and at least one plasticizer.

[0041] This means that the coating of a single coated delivery system according to the present invention has at least three components.

[0042] The first coating material is shellac and / or shellac ammonium salt.

[0043] Shellac is a natural product with interesting properties and exceptional versatility. Shellac is the refined product of the natural resin lac, the hardened secretion of the small parasitic insect Kerria Lacca, commonly known as the lac scale insect. It is the only known commercially available resin of animal origin.

[0044] Shellac is a natural substance with a complex mixture of esters and polyesters of polyhydroxy acids.

[0045] There are many commercial vendors that sell shellac.

[0046] Ammonium shellac is a modified shellac. It is made according to commonly known processes. Ammonium shellac is also commercially available.

[0047] The shellac and / or shellac ammonium salt is used in the single coating in an amount of 50-98 wt-% based on the total weight of the single coating layer. Preferably, it is used in an amount of 60 to 85 wt-%, more preferably 70 to 85 wt-%, based on the total weight of the single coating layer.

[0048] Preferably, shellac ammonium salt is used.

[0049] Thus, the present invention relates to a single coated delivery system (DS6) being coated delivery system (DS), (DS1), (DS1'), (DS1'', (DS1'''), (DS2), (DS3), (DS4), (DS4'), (DS4'', (DS4'''), (DS4''''), (DS5), (DS5') or (DS5''), wherein shellac and / or shellac ammonium salt is used in the single coating in an amount of 50-98 wt-% based on the total weight of the single coating layer.

[0050] Thus, the present invention relates to a single coated delivery system (DS6') being coated delivery system (DS), (DS1), (DS1'), (DS1'', (DS1'''), (DS2), (DS3), (DS4), (DS4'), (DS4'', (DS4'''), (DS4''''), (DS5), (DS5') or (DS5''), wherein shellac and / or shellac ammonium salt is used in the single coating in an amount of 60-85 wt-% based on the total weight of the single coating layer.

[0051] Thus, the present invention relates to a single coated delivery system (DS6''') being a coated delivery system (DS), (DS1), (DS1'), (DS1'', (DS1'''), (DS2), (DS3), (DS4), (DS4'), (DS4'', (DS4'''', (DS4''''), (DS5), (DS5') or (DS5''), wherein shellac and / or shellac ammonium salt is used in the single coating in an amount of 70-85 wt-% based on the total weight of the single coating layer.

[0052] The single coating also comprises at least one alginate having a viscosity of 10 to 800 mPas (measured as a 10% aqueous solution at 20° C.). The viscosity can be measured using all commonly known methods and devices.

[0053] Preferably, the viscosity of the at least one alginate in the single coating is between 10 and 500 mPas (measured as a 10% solution at 20° C.).

[0054] More preferably, the viscosity of the at least one alginate in the single coating is between 10 and 200 mPas (measured as a 10% solution at 20° C.).

[0055] Most preferably, the viscosity of at least one alginate in the single coating is between 10 and 100 mPas (measured as a 10% solution at 20° C.).

[0056] Thus, the present invention relates to a coated delivery system (DS), (DS1), (DS1'), (DS1'', (DS1'''), (DS2), (DS3), (DS4), (DS4'), (DS4'', (DS4'''), (DS4''''), (DS5), (DS5'), (DS5''), (DS6), (DS6') or (DS6''), wherein the viscosity of at least one alginate in the single coating is between 10 and 800 mPas (measured as a 10% aqueous solution at 20°C).

[0057] Thus, the present invention relates to a coated delivery system (DS), (DS1), (DS1'), (DS1'', (DS1'''), (DS2), (DS3), (DS4), (DS4'), (DS4'', (DS4'''), (DS4''''), (DS5), (DS5'), (DS5''), (DS6), (DS6') or (DS6'') wherein the viscosity of at least one alginate in the single coating is between 10 and 500 mPas (measured as a 10% solution at 20°C).

[0058] Thus, the present invention relates to a coated delivery system (DS), (DS1), (DS1'), (DS1'', (DS1'''), (DS2), (DS3), (DS4), (DS4'), (DS4'', (DS4'''), (DS4''''), (DS5), (DS5'), (DS5''), (DS6), (DS6') or (DS6'') wherein the viscosity of at least one alginate in the single coating is between 10 and 200 mPas (measured as a 10% solution at 20°C).

[0059] Thus, the present invention relates to a coated delivery system (DS), (DS1), (DS1'), (DS1'', (DS1'''), (DS2), (DS3), (DS4), (DS4'), (DS4'', (DS4'''), (DS4''''), (DS5), (DS5'), (DS5''), (DS6), (DS6') or (DS6'') having a viscosity of 10-100 mPas (measured as a 10% solution at 20°C).

[0060] Such alginates are known as ultra-low viscosity alginates.

[0061] Typically and preferably, this is sodium alginate. Such ultra-low viscosity alginates are commercially available from various suppliers (e.g., KIMICA Corporation, under the trade names KIMICA ALGIN ULV-L3, KIMICA ALGIN ULV-L5, KIMICA ALGIN ULV-1, KIMICA ALGIN ULV-3 and KIMICA ALGIN ULV-5).

[0062] Thus, the present invention relates to a coated delivery system (DS), (DS1), (DS1'), (DS1'', (DS1'''), (DS2), (DS3), (DS4), (DS4'), (DS4'', (DS4'''), (DS4''''), (DS5), (DS5'), (DS5''), (DS6), (DS6'), (DS6'', (DS7), (DS7'), (DS7'') or (DS7''').

[0063] The at least one alginate is used in the single coating in an amount of 0.5 to 10 wt-% based on the total weight of the single coating layer.

[0064] Preferably, it is used in an amount of 1 to 6 wt-%, more preferably 2 to 5 wt-%, based on the total weight of the single coating layer.

[0065] Thus, the present invention relates to a single coated delivery system (DS9) which is a coated delivery system (DS), (DS1), (DS1'), (DS1'', (DS1'''), (DS2), (DS3), (DS4), (DS4'), (DS4'', (DS4'''), (DS4''''), (DS5), (DS5'), (DS5''), (DS6), (DS6'), (DS6'', (DS7), (DS7'), (DS7'', (DS7'') or (DS8), wherein at least one alginate in the single coating is used in an amount of 0.5 to 10 wt-% based on the total weight of the single coating layer.

[0066] Thus, the present invention relates to a single coated delivery system (DS9') which is a coated delivery system (DS), (DS1), (DS1'), (DS1'', (DS1'''), (DS2), (DS3), (DS4), (DS4'), (DS4'', (DS4'''), (DS4'''', (DS4''''), (DS5), (DS5'), (DS5''), (DS6), (DS6'), (DS6'', (DS7), (DS7'), (DS7'', (DS7'') or (DS8), wherein at least one alginate in the single coating is used in an amount of 1-6 wt-% based on the total weight of the single coating layer.

[0067] Thus, the present invention relates to a single coated delivery system (DS9'') which is a coated delivery system (DS), (DS1), (DS1'), (DS1'', (DS1''), (DS1'''), (DS2), (DS3), (DS4), (DS4'), (DS4'', (DS4'''), (DS4''''), (DS5), (DS5'), (DS5''), (DS6), (DS6'), (DS6''), (DS7), (DS7'), (DS7'', (DS7'') or (DS8), wherein at least one alginate in the single coating is used in an amount of 2-5 wt-% based on the total weight of the single coating layer.

[0068] The third component of the single coating layer is one or more plasticizers.

[0069] The plasticizer can be any commonly used one. Suitable ones are, for example, glycols, glycerol, glycerol triacetate, polyethers, triethyl citrate.

[0070] Thus, the present invention relates to a single coated delivery system (DS10) which is a coated delivery system (DS), (DS1), (DS1'), (DS1'', (DS1'''), (DS2), (DS3), (DS4), (DS4'), (DS4'', (DS4'''), (DS4'''', (DS4''''), (DS5), (DS5'), (DS5''), (DS6), (DS6'), (DS6''), (DS7), (DS7'), (DS7'', (DS7''), (DS7''), (DS8), (DS9), (DS9') or (DS9'').

[0071] At least one plasticizer is used in the single coating in an amount of 1 to 30 wt-% based on the total weight of the single coating layer.

[0072] Preferably, it is used in an amount of 5 to 30 wt-%, more preferably 10 to 25 wt-%, based on the total weight of the single coating layer.

[0073] Thus, the present invention relates to a single coated delivery system (DS11) which is a coated delivery system (DS), (DS1), (DS1'), (DS1'', (DS1'''), (DS2), (DS3), (DS4), (DS4'), (DS4'', (DS4'''), (DS4''''), (DS5), (DS5'), (DS5''), (DS6), (DS6'), (DS6''), (DS7), (DS7'), (DS7'', (DS7'''), (DS8), (DS9), (DS9'), (DS9'') or (DS10), wherein at least one plasticizer in the single coating is used in an amount of 1 to 30 wt-% based on the total weight of the single coating layer.

[0074] Thus, the present invention relates to a single coated delivery system (DS11') which is a coated delivery system (DS), (DS1), (DS1'), (DS1'', (DS1'''), (DS2), (DS3), (DS4), (DS4'), (DS4'', (DS4'''), (DS4''''), (DS5), (DS5'), (DS5''), (DS6), (DS6'), (DS6''), (DS7), (DS7'), (DS7'', (DS7'''), (DS8), (DS9), (DS9'), (DS9'') or (DS10), wherein at least one plasticizer in the single coating is used in an amount of 5 to 30 wt-% based on the total weight of the single coating layer.

[0075] Thus, the present invention relates to a single coated delivery system (DS11'') which is a coated delivery system (DS), (DS1), (DS1'), (DS1'', (DS1'''), (DS2), (DS3), (DS4), (DS4'), (DS4'', (DS4'''), (DS4''''), (DS5), (DS5'), (DS5''), (DS6), (DS6'), (DS6''), (DS7), (DS7'), (DS7'', (DS7''), (DS8), (DS9), (DS9'), (DS9'') or (DS10), wherein at least one plasticizer in the single coating is used in an amount of 10 to 25 wt-% based on the total weight of the single coating layer.

[0076] It will be appreciated that all percentages of the components of a single coating layer will generally add up to 100.

[0077] The single coated delivery system according to the present invention is prepared according to commonly known and used processes such as fluidized bed coating, Wurster coating, bottom spray coating, tangential spray coating, and the like.

[0078] The novel delivery systems (DS), (DS1), (DS1'), (DS1'', (DS1'''), (DS2), (DS3), (DS4), (DS4'), (DS4'', (DS4''), (DS4'''', (DS4''''), (DS5), (DS5'), (DS5''), (DS6), (DS6'), (DS6''), (DS7), (DS7'), (DS7'', (DS7'''), (DS8), (DS9), (DS9'), (DS9''), (DS10), (DS11), (DS11') and / or (DS11'') according to the present invention may be used on their own or may be incorporated into any application form.

[0079] The novel delivery systems (DS), (DS1), (DS1'), (DS1'', (DS1'''), (DS2), (DS3), (DS4), (DS4'), (DS4'', (DS4''), (DS4'''', (DS4'''',), (DS5), (DS5'), (DS5''), (DS6), (DS6'), (DS6''), (DS7), (DS7'), (DS7'', (DS7'''), (DS8), (DS9), (DS9'), (DS9''), (DS10), (DS11), (DS11') and / or (DS11'') may be used by themselves or in any dietary supplement, food, feed product, personal care product or pharmaceutical product.

[0080] The novel delivery systems (DS), (DS1), (DS1'), (DS1'', (DS1'''), (DS2), (DS3), (DS4), (DS4'), (DS4'', (DS4''', (DS4'''', (DS4'''',) (DS5), (DS5'), (DS5''), (DS6), (DS6'), (DS6'', (DS7), (DS7'), (DS7'', (DS7'''',) (DS8), (DS9), (DS9'), (DS9''), (DS10), (DS11), (DS11') and / or (DS11'') may also be part of premix formulations which in turn may be used to formulate any dietary supplement, food, feed product, personal care product or pharmaceutical product.

[0081] The present invention also relates to a process for the production of a premix, a dietary supplement, a food, a feed product, a personal care product or a pharmaceutical product using at least one delivery system (DS), (DS1), (DS1'), (DS1'', (DS1'''), (DS2), (DS3), (DS4), (DS4'), (DS4'', (DS4''), (DS4'''', (DS4'''',), (DS5), (DS5'), (DS5''), (DS6), (DS6'), (DS6''), (DS7), (DS7'), (DS7'', (DS7'''), (DS8), (DS9), (DS9'), (DS9''), (DS10), (DS11), (DS11') and / or (DS11'').

[0082] The present invention also relates to a premix, dietary supplement, food, feed product, personal care product or pharmaceutical product comprising at least one delivery system (DS), (DS1), (DS1'), (DS1'', (DS1''',), (DS2), (DS3), (DS4), (DS4'), (DS4'', (DS4''',), (DS4'''', (DS4'''',), (DS5), (DS5'), (DS5'', (DS6), (DS6'), (DS6'', (DS7), (DS7'), (DS7'', (DS7'''',), (DS8), (DS9), (DS9'), (DS9'', (DS10), (DS11), (DS11') and / or (DS11'').

[0083] The following examples serve to illustrate certain embodiments of the invention claimed herein. All percentages are given by weight and all temperatures are given in degrees Celsius.

[0084] [Example] [Example 1] For the spray solution, 0.13 g of sodium alginate (Kimica Algin ULV-L3, Kimica Co., Ltd., Japan) and 0.9 g of glycerol (Sigma Aldrich, Switzerland) were dissolved in 66.4 g of shellac ammonium salt solution (25% solids, Aquagold SSB, Stroever, Germany) under gentle stirring.

[0085] 100 g of core granules containing 68% ascorbic acid were placed in a laboratory scale fluid bed processor (WFP mini, DMR, Switzerland) in bottom spray configuration and fluidized. The inlet air temperature was set at 80°C. The shellac-alginate-glycerol solution was sprayed onto the core pellets. The spray rate was set to maintain a product temperature of 49-59°C. After coating, the product was dried in the fluid bed at 45-52°C. 114 g of coated product was obtained.

[0086] The coating layer contains 94.2% shellac ammonium salt, 0.7% sodium alginate and 5.1% glycerol as a plasticizer.

[0087] [Table 1]

Claims

1. (a) a solid core containing vitamin C; (b) shellac and / or shellac ammonium salt; At least one alginate having a viscosity of 10 to 800 mPas in a 10% aqueous solution at 20°C, and at least one plasticizer a coating comprising: A single coated delivery system comprising:

2. 60 to 95 wt-% of the core based on the total weight of the single coated delivery system; 10. The single coated delivery system of claim 1, comprising 5 to 40 wt-% of said coating layer based on the total weight of said single coated delivery system.

3. 70-90 wt-% of the core based on the total weight of the single coated delivery system; 10-30 wt-% of said coating layer based on the total weight of said single coated delivery system.

4. 3. The single coated delivery system of claim 1 or 2, wherein the coating layer is at least 5 μm thick.

5. 5. The single coated delivery system of claim 4, wherein the coating layer has a thickness of 5 μm to 50 μm.

6. 10. The single coated delivery system of claim 1, wherein the core comprises up to 100 wt-% vitamin C based on the total weight of the core.

7. 10. The single coated delivery system of claim 1 or 6, wherein the size of the single coated delivery system is 100 to 2300 μm.

8. 2. The single coated delivery system of claim 1, wherein the shellac and / or shellac ammonium salt is used in the single coating in an amount of 50 to 98 wt-% based on the total weight of the layers of the single coating.

9. A single-coated delivery system as described in claim 1, wherein the viscosity of at least one alginate in the single coating is 10 to 800 mPas (measured as a 10% solution at 20°C).

10. 10. The single coated delivery system of claim 1, wherein the at least one alginate is sodium alginate.

11. A single coated delivery system as described in claim 1 or 10, wherein the at least one alginate is used in the single coating in an amount of 0.5 to 10 wt-% relative to the total weight of the single coating layer.

12. 10. The single coated delivery system of claim 1, wherein the at least one plasticizer is selected from the group consisting of glycols, glycerol triacetate, polyethers, and triethyl citrate.

13. A single-coated delivery system as described in claim 1, wherein the at least one plasticizer in the single coating is used in an amount of 1 to 30 wt.% based on the total weight of the layers of the single coating.