Antiviral activity containing coronavirus, antifungus activity, and oil paint with antiviral activity, as well as, virus containing coronavirus, mold, and method for disinfecting bacteria

Abstract

To provide an oil paint having antiviral activity including coronavirus, by dissolving instability to lose biological activity by forming photo-instability of silver (1) ions and many negative ions and insoluble salts while maintaining biological activity of the silver (1) ions, and a method for preventing coronavirus infection therewith.SOLUTION: To provide an oil paint that includes a resin, volatile organic solvents, water-soluble silver (1) ions as an additive, fulvic acid, dication that stabilizes silver (1) ions, anions that do not reduce the silver (1) ions, and a hydrous powder that carries linear polyethyleneimine.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to an oil paint having antiviral activity, antifungal activity, and antibacterial activity including a coronavirus, and more specifically, while maintaining excellent activity as an external disinfectant of silver (I) ions, the instability of silver (I) ions is eliminated, and an oil paint having antiviral activity, antifungal activity, and antibacterial activity including a coronavirus, and a method for disinfecting viruses, fungi, and bacteria including a coronavirus using the oil paint.

Background Art

[0002] As one of the main transmission routes of coronavirus infection, in places where a large number of unspecified people gather, patients infected with the coronavirus spread saliva by coughing or talking, or touch objects such as utensils, walls, and floors with contaminated hands, thereby contaminating the objects with the coronavirus and expanding the infection. This infection route has the potential to spread infection anywhere where a large number of people gather.

[0003] In addition, although the virus can be removed by wiping an object contaminated with the coronavirus with, for example, ethanol, a perchlorate solution, or a neutral detergent, the manual wiping work is very difficult. Moreover, the duration of the antiviral activity of the drug used is extremely short, and it cannot be said to be a disinfectant that keeps the object disinfected from the coronavirus. Therefore, there has been a demand for developing a disinfectant that is effective against the coronavirus for a long time.

[0004] Here, silver (I) ions have a bactericidal activity of killing contacted viruses, fungi, bacteria, etc., and moreover, they also have excellent biological activity as an external disinfectant in that they are not toxic to large animals such as humans, livestock, dogs, and cats.

[0005] However, silver(I) ions have the weakness of being unstable and having non - persistent activity. That is, silver(I) ions react with many anions, especially chloride ions widely present in the environment, to form insoluble silver(I) salts, or are photoreduced to silver fine particles and lose their antimicrobial activity. For this reason, silver(I) ions have been considered not available for disinfection of general public facilities.

Prior Art Documents

Patent Documents

[0006]

Patent Document 1

Patent Document 2

Patent Document 3

Patent Document 4

Non - Patent Documents

[0007]

Non - Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0008] The first object of the present invention is to provide an external oil - based paint containing silver(I) ions as an active ingredient, which has antiviral activity, antifungal activity, and antibacterial activity against coronaviruses, while maintaining the excellent antimicrobial biological activity of silver(I) ions and eliminating the drawbacks that silver(I) ions react with many anions to change into insoluble silver(I) salts or are easily photoreduced to silver fine particles and lose their activity.

[0009] Moreover, a second object of the present invention is to provide a method for disinfecting viruses including coronaviruses, molds, and bacteria, which can more easily form a coating film in which silver (I) ions are dispersed than water-based paints and two-component emulsion paints by using an oil-based paint containing silver (I) ions as an active ingredient.

[0010] Furthermore, a third object of the present invention is to provide a paint that forms a strong and beautiful coating surface when the oil-based paint is applied as a coating agent, and also forms a beautiful, strong, and non-slip floor surface when used as a flooring material.

Means for Solving the Problems

[0011] The oil-based paint of the present invention for solving such problems is an oil-based paint containing a resin, a volatile organic solvent, and an additive, wherein the additive contains water-soluble silver (I) ions, fulvic acid, [poly-oxyethylene dimethyliminoethylene dimethyliminoethylene] dication aqueous solution, one or more anions that neutralize the silver (I) ions and the [poly-oxyethylene dimethyliminoethylene dimethyliminoethylene] dication and do not reduce the silver (I) ions and are non-toxic, and a powder supporting an additive component containing linear polyethyleneimine.

[0012] Here, it is preferable that the powder has a large water retention capacity.

[0013] In addition, in the oil-based paint, one or more anions that do not reduce silver (I) ions and are non-toxic can be one or more selected from nitrate anions or acetate anions.

[0014] And, in the oil-based paint of the present invention, when the coating film formed by applying it to an object is set to 100% by mass of the mass of the coating film, silver (I) ions are 10 -7 ~10 -4Containing % by mass, converting [[poly-oxyethylene dimethyliminoethylene dimethyliminoethylene]] dication to [[poly-oxyethylene dimethyliminoethylene dimethyliminoethylene]] dichloride by mass, containing 0.2 to 10.0% by mass, containing linear polyethyleneimine in an amount of 0.2 to 2.0% by mass, and preferably the ratio of the molar equivalent of silver(1) ions contained in the coating film to the carboxyl group equivalent of fulvic acid is in the range of 1:10 to 1:100.

[0015] Furthermore, in the oil-based paint, the resin contained in the oil phase may be one or more selected from synthetic polymer resins in the group consisting of silicone resin, epoxy resin, polyurethane resin, (meth)acrylic resin, and polyester resin.

[0016] Among them, it is more preferable that the resin contained in the oil phase of the present invention is a silicone resin.

[0017] And also, the method for disinfecting viruses including the coronavirus, molds, and bacteria of the present invention is characterized by applying the oil-based paint according to any one of claims 1 to 6 to an object (excluding humans) to form a coating film.

Effects of the Invention

[0018] The oil-based paint of the present invention contains silver(1) ions as an additive and has strong antimicrobial activity against a wide range of microorganisms such as viruses including the coronavirus, molds, and bacteria. Moreover, although most antimicrobial substances have the effect of preventing the growth of viruses, molds, bacteria, etc., if left as they are, bacteria, etc. may regrow. However, silver(1) ions have a microbicidal activity of killing the contacted viruses, molds, and bacteria, etc.

[0019] In addition, the oil-based paint of the present invention contains, as additives, fulvic acid that stabilizes silver(I) ions, [poly-oxyethylene dimethyliminoethylene dimethyliminoethylene] dication that prevents the photo-reduction of silver(I) ions into silver fine particles and their deactivation, nitrate anions or acetate anions that do not reduce silver(I) ions and are non-toxic, and linear polyethyleneimine that disperses silver(I) ions on the surface of the coating film. Therefore, the coating film formed by applying the coating agent to the object has the characteristic that the strong bactericidal activity of silver(I) ions can be sustained over a long period of time, and the excellent activity as a topical disinfectant can be sustained.

[0020] Furthermore, since the oil-based paint of the present invention contains a polymer resin paint as a coating component of the oil phase, a strong and beautiful coating film can be formed. In particular, the present invention has the characteristic that a strong, beautiful, and non-slip floor surface can be formed by using a silicone resin raw material as a raw material for the polymer resin paint for the coating film.

[0021] Furthermore, the method for disinfecting viruses, molds, and bacteria including the coronavirus according to the present invention is a simple method of directly applying the oil-based paint to the object (excluding humans) and drying it to form a coating film. It is easier to apply than a two-component emulsion paint, and the finish is beautiful. Moreover, since the disinfected effect lasts for a long time, it has the characteristic that the object (excluding humans) can be easily, beautifully, and disinfected for a long time.

Embodiments for Carrying Out the Invention

[0022] The present invention will be described in detail below. This description is for explaining the present invention and does not limit the technical scope of the present invention. The present invention can be variously modified and implemented within the range not departing from the technical scope of the present invention.

[0023] The oil-based paint of the present invention is an oil-based paint containing a resin, a volatile organic solvent, and an additive, wherein the additive is a water-soluble silver (I) ion, fulvic acid, [poly-oxyethylene dimethyliminoethylene dimethyliminoethylene] dication, and one or more anions that neutralize silver (I) ions and [poly-oxyethylene dimethyliminoethylene dimethyliminoethylene] dication without reducing silver (I) ions and are non-toxic, and an additive containing a powder carrying an additive component containing linear polyethyleneimine (see, for example, Patent Document 3). Here, as the powder, a powder having a large water absorption is preferable. Examples of the powder include fine powders of lightweight inorganic substances such as diatomaceous earth and water-absorbing polymers.

[0024] <Silver (I) ion> The silver (I) ion according to an embodiment of the present invention has strong antimicrobial activity against a wide range of microorganisms such as viruses including the coronavirus, molds, and bacteria. Moreover, most antibiotics only have the effect of inhibiting the growth of viruses, molds, bacteria, etc., and if left untreated, the bacteria may regrow. However, silver (I) ions have a bactericidal activity of killing the contacted viruses, molds, and bacteria, etc. Moreover, it has excellent biological activity as an external bactericide, being non-toxic to large animals such as humans, livestock, dogs, and cats.

[0025] Therefore, the oil-based paint having antiviral activity, antifungal activity, and antibacterial activity including the coronavirus according to the first embodiment of the present invention, when the mass of the oil-based paint contained in the coating film formed by applying it to a target (excluding humans) is set to 100% by mass, the coating film preferably contains 10 -7 ~10 -4 % by mass of silver (I) ions, and more preferably contains 5×10 -7 ~5×10 -5 % by mass. If the silver (I) ion content is less than 10 -7 % by mass, the antibacterial, antifungal, and antiviral activities of the coating film may not be sufficient, and if it exceeds 10 -4Adding more than the mass % may not enhance the activity of the composition and is not economically preferable.

[0026] In addition, the silver(I) ions of the present invention shall also include complex ions of silver(I). Examples of preferable silver(I) complex ions include, for example, the Tollens reagent (Ag(NH3)2OH), but the silver(I) complex ions of the present invention are not limited to the Tollens reagent. Furthermore, metallic silver obtained by reducing silver(I) ions is less likely to become an allergen for noble metal allergy and is a safe metal that has been used as tableware since ancient times.

[0027] <fulvic acid> Also, the oily paint of the present invention preferably contains fulvic acid (see, for example, Non-Patent Document 1). Here, according to the Chemical Dictionary (Kyoritsu Shuppan, 1964), fulvic acid is a type of humic substance obtained as an extract from humus soil, and is "a substance that remains in the acidic supernatant when humic acid is extracted from soil or coal with dilute alkali and precipitated with an inorganic acid, and gives the supernatant a yellow to orange-yellow color. When extracted as an aqueous fulvic acid solution from the supernatant and dried, it gives an amorphous substance soluble in water and ethanol". Fulvic acid does not have a single chemical structural formula and "varies widely in composition and molecular weight depending on the raw material and collection conditions and is not constant".

[0028] And the fulvic acid used in the present invention can be used by freeze-drying an aqueous solution of purified fulvic acid produced by the method described in Non-Patent Document 1, for example.

[0029] Also, the content of the purified fulvic acid obtained by the method described in Non-Patent Document 1 is preferably estimated from the carboxyl group equivalent of the aqueous fulvic acid solution before freeze-drying. Here, the carboxyl group equivalent of the fulvic acid aqueous solution is the molar equivalent number of carboxyl groups present in a unit amount of the fulvic acid aqueous solution, and can be expressed, for example, as [moles / unit amount]. Further, the carboxyl group equivalent can also be determined, for example, by a neutralization titration method or a spectrophotometric method by comparison with a standard product.

[0030] The structural formulas of fulvic acid described in Patent Document 4 and Non-Patent Document 1 are presumed structural formulas. However, upon examination with reference to other reports, the macroscopic structure of fulvic acid has, as a common partial structure, a (condensed) benzene ring portion with a strong and planar structure, a hydrophobic portion having a carbon chain with a high degree of freedom of conformational change, and a hydrophilic portion having many carboxyl groups and hydroxyl groups. For this reason, fulvic acid is presumed to be distributed in large amounts at the interface between the oily resin raw material and water and to stabilize silver(I) ions.

[0031] Here, it is preferable that the ratio of the molar equivalent of the carboxyl group of the fulvic acid contained in the disinfectant composition of this example to the molar equivalent of silver(I) ions is in the range of 1:10 to 1:100. If the ratio of the molar concentration of silver(I) ions to the carboxyl group equivalent of the fulvic acid aqueous solution is less than 1:10, the amount of fulvic acid is insufficient and the silver(I) ions become unstable. Also, even if a large amount of fulvic acid is added such that the ratio exceeds 1:100, the stability of the silver(I) ions cannot be further increased, which is not economically preferable.

[0032] <Dispersant> The antibacterial coating material for flooring of the present invention preferably contains a dispersant for the purpose of stably dispersing silver(I) ions at a high concentration in the coating film. As the dispersant, for example, polyvinylpyrrolidone is described in Patent Document 1, and a polymer substance containing a linear polyethyleneimine structure is described in Patent Document 3.

[0033] <Distribution of silver(I) ions> Therefore, in order to examine the effect of the dispersant, a linear polyethyleneimine or polyvinylpyrrolidone was further added as a dispersant to a composition containing silver (I) ions, fulvic acid aqueous solution, [poly-oxyethylene dimethyliminoethylene dimethyliminoethylene] dication, and one or more anions that do not reduce the silver (I) ions and are non-toxic, and an oil-based paint was applied and solidified to produce a coating film.

[0034] As described in paragraph

[0063] , the produced coating film was polished parallel to the surface using a polishing machine, separated, suspended in a liquid medium, and the antibacterial activity of each fraction was compared by the liquid medium dilution method. As a result, the chips of the coating film of Comparative Example 2 that did not contain a dispersant showed only weak antibacterial activity, but the chips of the fraction close to the surface of the coating film of Example 1 containing linear polyethyleneimine as a dispersant showed strong antibacterial activity, and the chips of the fraction close to the surface of the coating film containing polyvinylpyrrolidone of Example 5 also showed moderate antibacterial activity. These dispersants can be considered to disperse and hold silver (I) ions at a high concentration on the surface layer of the hydrophobic polymer resin layer.

[0035] <An anion that does not reduce silver (I) ions and is non-toxic> On the other hand, silver (I) ions have the problem of being unstable and having non-sustained activity. That is, silver (I) ions react with many anions including chloride ions widely present in the environment to form insoluble silver (I) salts and become inactivated. For this reason, the anions contained in the paint according to the first embodiment of the present invention are preferably one or more anions that do not reduce silver (I) ions and are non-toxic.

[0036] Among them, nitrate ions and acetate ions can be mentioned as anions that can be preferably used in the present invention.

[0037] <[Poly-oxyethylene dimethyliminoethylene dimethyliminoethylene] dication> Furthermore, silver (I) ions have the weakness of being directly photoreduced to silver fine particles and losing their antimicrobial activity. However, it has been found that the known antibacterial quaternary ammonium compound [poly-oxyethylene dimethyliminoethylene dimethyliminoethylene] dication (CAS No 31512-74-0) has the effect of stabilizing silver (I) ions and maintaining the excellent antibacterial, antifungal and antiviral effects of silver (I) ions. (See, for example, Patent Document 2).

[0038] However, [poly-oxyethylene dimethyliminoethylene dimethyliminoethylene] dication is commercially available in the form of a dichloride salt that forms an insoluble salt with silver (I) ions, and thus the commercial product could not be used. Moreover, free [poly-oxyethylene dimethyliminoethylene dimethyliminoethylene] dihydroxide is a strongly alkaline and viscous liquid that cannot be separated from water and is difficult to handle. Therefore, it is preferable to weigh it in the form of [poly-oxyethylene dimethyliminoethylene dimethyliminoethylene] dichloride and then exchange the chloride ions for anions that do not reduce silver (I) ions and are non-toxic before use.

[0039] [Resin] Furthermore, in the present invention, the resin forming the coating film may be one or more of synthetic polymer resins in the group consisting of epoxy resins, silicone resins, polyurethane resins, (meth)acrylic resins, and polyester resins. Among these, the polymer resin is more preferably a silicone resin.

[0040] ≪Production Example≫ Hereinafter, the present invention will be described with reference to production examples and examples. This description is for explaining the present invention and does not limit the technical scope of the present invention.

[0041] [Poly-oxyethylene dimethyliminoethylene dimethyliminoethylene] diacetate aqueous solution (Production Example 1) A solution prepared by dissolving 10.0 kg of [[Polyoxyethylene dimethyliminoethylene dimethyliminoethylene]] dichloride in 30.0 kg of deionized water was passed through a column filled with an acetate-type basic ion exchange resin in an amount greater than the ion exchange equivalent, and eluted with deionized water to collect 50 kg of an eluate containing an aqueous solution of the target diacetate. An aqueous solution of 50 kg containing 20% [[Polyoxyethylene dimethyliminoethylene dimethyliminoethylene]] diacetate in terms of the mass of [[Polyoxyethylene dimethyliminoethylene dimethyliminoethylene]] dichloride was obtained.

[0042] [fulvic acid] (Production Example 2) According to the description in Non-Patent Document 1, 10.0 kg of humic soil obtained by removing the surface soil of a broad-leaved forest, drying, and pulverizing it was added to 200 kg of an equal-volume mixture of 0.1 M aqueous sodium hydroxide solution and 0.1 M aqueous disodium hydrogen phosphate solution, gently stirred at 50 °C for 24 hours, and then filtered. 3M sulfuric acid was added to the filtrate to adjust the pH to 1, and the mixture was left at room temperature for 24 hours. Then, it was centrifuged to remove the humic acid fraction, and a crude fulvic acid aqueous solution was obtained. The crude fulvic acid aqueous solution was passed through a column filled with 20.0 kg of activated carbon to adsorb the fulvic acid. After washing the activated carbon column with water, it was eluted with 0.1 M aqueous sodium hydroxide solution, and the eluate was passed through columns of Amberlite IRA400 and Amberlite IR120 to remove inorganic ions, obtaining 8.3 kg of a purified fulvic acid aqueous solution. The carboxyl group equivalent of the obtained purified fulvic acid aqueous solution was 45.2 milliequivalent of carboxyl groups / kg of solution by the neutralization titration method.

[0043] [Additive] The mixing order and method of the additive of the present invention are not particularly limited as long as they do not interfere with the production of the disinfectant composition of the present invention. For example, an aqueous solution of [[Poly-oxyethylene dimethyliminoethylene dimethyliminoethylene]] diacetate, fulvic acid obtained by freeze-drying the aqueous fulvic acid solution produced in Production Example 2, linear polyethyleneimine, and a solution in which silver(1) ions are dissolved in a small amount of deionized water are added. If necessary, a pH adjuster using an anion that does not reduce silver(1) ions and is non-toxic is added to adjust the pH. Further, fine powder of diatomaceous earth is added and stirred to powderize to obtain an additive.

[0044] (Production Example 3) 10 kg of an aqueous solution containing 20% [[Poly-oxyethylene dimethyliminoethylene dimethyliminoethylene]] diacetate in terms of the mass of dichloride described in Production Example 1, the powder obtained by freeze-drying 8.3 kg of the aqueous fulvic acid solution produced in Production Example 2, 100 g of linear polyethyleneimine, and 1.57 g of silver(1) nitrate dissolved in a small amount of water are added. The pH is adjusted to 6.5 - 7.5 using a 2M acetic acid aqueous solution or a 2M sodium hydroxide aqueous solution, and after stirring to make it uniform, fine powder of diatomaceous earth is added so that the total amount is 30 kg. The total amount is stirred and powdered to obtain the additive of Production Example 3 of the present invention.

[0045] Further, the additive of the present invention can further contain fragrance additives such as surfactants, organic solvents, thickeners, antioxidants, light stabilizers, defoaming agents, and fragrances. Further, the oil-based paint of the present invention can contain pigments.

[0046] ≪Examples≫ <Oil-based paint> (Example 1) 60 parts by mass of silicone resin, 10 parts by mass of pigment, 30 parts by mass of the additive produced in Example 1, and 100 parts by mass of thinner for silicone resin are added and stirred to produce 200 parts by mass of the oil-based paint of Example 1.

[0047] ≪Comparative Examples≫ (Comparative Example 1) An oil-based paint was produced in the same manner as in Example 1, except that an additive without adding silver nitrate was used.

[0048] (Comparative Example 2) Similar to Example 1, but an oil-based paint of Comparative Example 3 was produced using an additive without adding fulvic acid.

[0049] (Comparative Example 3) Similar to Example 1, but an oil-based paint of Comparative Example 3 was produced using an additive without adding [poly-oxyethylene dimethyliminoethylene dimethyliminoethylene] diacetate.

[0050] (Comparative Example 4) Similar to Example 1, but an oil-based paint of Comparative Example 4 was produced using an additive without adding linear polyethyleneimine.

[0051] ≪Test Example≫ <Test Example 1> (Antibacterial Test) 〇Test Outline: The antibacterial activities of the oil-based paints according to Example 1 and Comparative Examples 1 to 4 of the present invention were measured. 〇Method A culture solution obtained by inoculating a bacterial solution of Staphylococcus aureus or Escherichia coli into a Nutrient Broth liquid medium and performing preculture by shaking at 30 ± 1°C for 18 hours was diluted 100-fold with a fresh Nutrient Broth medium, and 100 μg of the diluted solution was placed in a 96-well microplate. To this, the oil-based paints according to Example 1 and Comparative Examples 1 to 4 of the present invention were diluted so that the silver ion concentration in the first well was 10 mg / kg, and serially diluted 10-fold in two-fold steps. 50 μL of each of the obtained test solutions was added to each well of a 96-well microplate. The microplate was allowed to stand and cultured at 31 ± 1°C in the dark for 48 hours (Escherichia coli) or 24 hours (Staphylococcus aureus). The culture solution was inoculated into an agar-containing medium, and the presence or absence of bacterial growth was determined by whether the bacteria grew or not, and the minimum inhibitory concentration was measured. The measurement results are shown in Table 1.

[0052] Minimum Inhibitory Concentration

Table 1

[0053] The oil-based paints of Example 1 and Comparative Examples 2, 3, and 4 in which silver (I) ions have activity showed strong antibacterial properties, but the oil-based paint of Comparative Example 1 that does not contain silver (I) ions did not show antibacterial activity.

[0054] <Test Example 2> (Light stability test) 〇Test outline Assuming the case where the antibacterial, antifungal, and antiviral disinfectant composition of the present invention is applied to the surface of an object, the persistence of the antibacterial action of the oil-based paints of Example 1 and Comparative Examples 1 to 4 under light irradiation was measured. Test bacterium: S. aureus IID 1677 ·Test sample: The oil-based paints of Example 1 of the present invention and Comparative Examples 1 to 4 ·Test conditions: The oil-based paints produced in Example 1 and Comparative Examples 1 to 4 were put into glass test tubes, the test tubes were sealed with stoppers, and left under fluorescent lamp irradiation (400 lx) at 25°C. The minimum inhibitory concentration (MIC) of each sample was measured at predetermined time intervals by the method according to Test Example 1. The measurement results are shown in Table 2.

[0055]

Table 2

[0056] As shown in Table 2, the oil-based paint according to Example 1 of the present invention maintained antibacterial activity until 120 hours under irradiation (fluorescent lamp, 400 lx), and the oil-based paint without linear polyethyleneimine according to Comparative Example 4 also maintained antibacterial activity for 120 hours equivalent to that of Example 1. However, the oil-based paint of Comparative Example 1 that does not contain silver (I) ions did not show antibacterial properties, the oil-based paint of Comparative Example 3 that does not contain the light stabilizer [poly-oxyethylene dimethyliminoethylene dimethyliminoethylene] dication was inactivated within 24 hours, and the oil-based paint of Comparative Example 2 that does not contain fulvic acid was also less stable than Example 1.

[0057] <Test Example 3> (Antifungal test) 〇Test outline: The antifungal test was carried out according to the "Fungus resistance test method" of JIS Z 2911:2010 "Method": Conducted in accordance with the paint test. · Test bacteria: Trichophyton rubrum 2659 (dermatophyte) · Test samples: Coating agents of Example 1 of the present invention and Comparative Examples 1 to 4 · Test method: For test pieces (30 mm × 30 mm, 6 pieces for each sample), the test solution was sprayed at a rate of 10.0 mL / m 2 and air-dried in the dark for 1 hour. Then, a mixed spore suspension of mold was sprayed at a rate of 10.0 mL / m 2 and placed in a thermostat maintained at 26 ± 2°C and a humidity of 95% - 99% for 4 weeks of cultivation in a mold-free state and in the dark in the air, and the mold growth state was determined. The results are shown in Table 3.

[0058] Growth status of hyphae

Table 3

[0059] As shown in Table 3, the oil-based paint of Example 1 of the present invention and Comparative Example 4, which is obtained by simply removing linear polyethyleneimine from Example 1, showed antifungal activity, while Comparative Examples 1 to 3 did not show antifungal properties.

[0060] <Test Example 4> (Antiviral test against coronavirus) ○ Testing institution: Kobe Testing Center, Japan Textile Products Technology Center, Incorporated Administrative Agency 〇 Test overview · Test samples: Oil-based paint of Example 1 · Control samples: Phosphate buffer solution · Test conditions: Test virus: Severe acute respiratory syndro me coronavirus 2 (SARS-CoV-2)NI ID isolate IID isolate: JPN / TY / WK 521 (distributed by the National Institute of Infectious Diseases) Method for measuring infectious titer: Plaque assay

[0061] ​ Test results The test results are shown in Table 4. Test virus suspension concentration: 2.8×108 PFU / mL [Table 4]

[0062] As shown in Table 4, the oil-based paint of Example 1 was shown to block SARS-CoV-2 NIID isolate; JPN / TY / WK-521 (coronavirus).

[0063] <Test Example 5> (Silver(1) ion distribution test) Test Overview Tests were conducted to verify whether silver(1) ions incorporated into the surface of a solid have an antibacterial effect on bacteria distributed in liquids. Test sample: Antibacterial floor surface coated with oil-based paint prepared in Example 1, Comparative Example 1, and Comparative Example 5 Test conditions: The coating film (thickness 0.5 mm) was ground parallel to the surface to 0.2 mm using a grinding machine. 100 mg of the ground powder was taken and suspended in 10 mL of liquid medium. After stirring for 1 hour, dilute the mixture in liquid medium by doubling according to Test Example 3. The antibacterial activity of each fraction was compared by this method. Culture medium used: Standard liquid medium, Eiken Chemical Pharmaceutical Test bacteria: Bacillus subutilis natto (obtained from natto) The results are shown in Table 5.

[0064] [Table 5]

[0065] As shown in Table 5, the chips scraped from the coating film without the dispersant of Comparative Example 1 showed only weak antibacterial activity, while the chips scraped from the coating film containing linear polyethyleneimine as the dispersant of Example 1 showed strong antibacterial activity, and the chips scraped from the coating film containing polyvinylpyrrolidone instead of linear polyethyleneimine of Comparative Example 5 also showed moderate antibacterial activity. Therefore, these dispersants are considered to be unevenly distributed on the surface layer of the hydrophobic polymer resin layer and retain silver(I) ions at a high concentration.

[0066] Using the coronavirus, it is not possible to conduct a test to actually verify whether the silver(I) ions incorporated into the coating film have an antiviral effect on the coronavirus dispersed in the liquid from the perspective of safety. However, this test showed that the silver(I) ions incorporated into the solid coating film have an antibacterial effect on the bacteria dispersed in the liquid.

Claims

1. An oil-based paint comprising a resin, a volatile organic solvent, and an additive, wherein the additive comprises a water-soluble silver (I) ion, fulvic acid, an aqueous solution of [poly-oxyethylene dimethyliminoethylene dimethyliminoethylene] dication, one or more anions that neutralize the silver (I) ion and the [poly-oxyethylene dimethyliminoethylene dimethyliminoethylene] dication and do not reduce the silver (I) ion and are non-toxic, and a powder carrying an additive component containing linear polyethyleneimine, and having antiviral activity, antifungal activity, and antibacterial activity against a coronavirus-containing oil-based paint.

2. The oil-based paint having antiviral activity, antifungal activity, and antibacterial activity against a coronavirus-containing according to claim 1, wherein the powder is a powder having a large water retention capacity.

3. The oil-based paint having antiviral activity, antifungal activity, and antibacterial activity against a coronavirus-containing according to claim 2, wherein the anion is one or more selected from nitrate anions or acetate anions.

4. When the coating film formed by applying the oil-based paint to the target has a mass of 100% by mass, it contains 10 －７ to 10 －４ % by mass of silver <1> ions, contains 0.2 to 10.0% by mass of the [[poly-oxyethylene dimethyliminoethylene dimethyliminoethylene]] dication in terms of the mass of [[poly-oxyethylene dimethyliminoethylene dimethyliminoethylene]] dichloride, contains 0.2 to 2.0% by mass of the linear polyethyleneimine, and the ratio of the molar equivalent of silver (1) ions contained in the coating film to the carboxyl group equivalent of the fulvic acid aqueous solution is in the range of 1:10 to 1:

100. The oil-based paint having antiviral activity, antifungal activity, and antibacterial activity against the coronavirus according to claim 3, characterized in that.

5. The oil-based paint having antiviral activity, antifungal activity, and antibacterial activity against a coronavirus-containing according to claim 4, wherein the resin is one or more selected from synthetic polymer resins in the group consisting of silicone resins, epoxy resins, polyurethane resins, (meth)acrylic resins, and polyester resins.

6. The oil-based paint having antiviral activity, antifungal activity, and antibacterial activity against a coronavirus-containing according to claim 5, wherein the resin is a silicone resin.

7. A method for disinfecting a virus infection, a fungal infection, and a bacterial infection containing a coronavirus, characterized by applying the oil-based paint according to any one of claims 1 to 6 to a subject (excluding humans) to form a coating film.

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