Composition for oral cavity

Abstract

To provide a composition for an oral cavity capable of realizing a smaller pouch product for an oral cavity.SOLUTION: A composition for an oral cavity includes nicotine, with bulk density of 0.4 g / cm3 or more.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to oral compositions. [Background technology]

[0002] Oral compositions, which are the filling material for oral pouch products, typically contain an organic material such as microcrystalline cellulose (MCC) as a base material. However, the particles of organic base materials swell when exposed to moisture or heat, reducing the bulk density of the composition after production. This inevitably requires a large amount of composition to ingest a given amount of nicotine, necessitating the use of a large pouch that is unpleasant to the palate. Patent Document 1 discloses an elongated oral pouch product with a short side of 10 mm and a short-to-long side ratio of 3 to 6, designed to fit the user's mouth. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] European Patent Publication No. 3087852 Summary of the Invention [Problem to be solved by the invention]

[0004] The inventors have conceived the idea that a smaller oral pouch product can be provided by using an oral composition having a specific bulk density. In view of this situation, an object of the present invention is to provide an oral composition that can achieve a smaller oral pouch product. [Means for solving the problem]

[0005] The inventors have found that an oral composition having a specific bulk density can solve the above problems. Aspect 1 Contains nicotine and has a bulk density of 0.4 g / cm 3 The oral composition is as described above. Aspect 2 10. The oral composition of embodiment 1, comprising an inorganic porous substrate. Aspect 3 3. The oral composition according to claim 2, wherein the content of the inorganic porous substrate is 6% by weight or more. Aspect 4 the inorganic porous material is selected from the group consisting of silica, silicates, alumina, zeolites, hydroxyapatite, hydrotalcite, and combinations thereof; 4. The oral composition according to claim 2 or 3. Aspect 5 5. The oral composition according to any one of aspects 2 to 4, wherein the inorganic porous substrate has an average particle size of 60 to 500 μm. Aspect 6 6. The oral composition according to any one of Aspects 1 to 5, wherein the water content is 10 to 70 wt %. Aspect 7 The oral composition according to any one of aspects 1 to 6, A packaging material for packaging the oral composition; An oral pouch product comprising: [Effects of the Invention]

[0006] The present invention can provide an oral composition and an oral pouch product that have excellent storage stability. DETAILED DESCRIPTION OF THE INVENTION

[0007] The present invention will be described in detail below. In the present invention, "X to Y" includes the end values, i.e., X and Y. An oral product is a product in which the active ingredient is ingested through the oral mucosa via saliva while the product is held in the oral cavity. An oral composition is a composition used in an oral product.

[0008] 1. Oral composition The oral composition according to this embodiment (hereinafter also simply referred to as the "composition") contains nicotine and preferably contains an inorganic porous material as a base material. The base material is a material that constitutes the matrix of the composition and is also called an excipient.

[0009] (1) Bulk density The bulk density of the composition is 0.4 g / cm3 That is all. A composition having this bulk density can provide a compact oral pouch product. The upper limit of the bulk density is not limited, but from the viewpoint of adjusting the amount of components in the composition to an appropriate range, it is preferable to set the bulk density to 0.8 g / cm. 3 The bulk density is measured in accordance with Japanese Pharmacopoeia 3.01. Specifically, the powder of the composition is allowed to fall freely from a hopper placed above the powder, and the powder is dropped to a depth of 100 cm. 3 The powder is allowed to flow into the measuring container until it overflows. The powder on the top and sides of the measuring container is scraped off, and the weight of the composition powder is measured. The loose bulk density is calculated using the following formula, which is taken as the bulk density. Loose bulk density (g / cm 3 ) = Weight of composition powder (g) / Volume of measuring container (cm 3 )

[0010] (2) Nicotine The composition contains nicotine. Nicotine may be contained in the form of nicotine alone or in the form of a nicotine-containing raw material. The nicotine-containing raw material refers to a raw material containing nicotine, such as a nicotine salt or stabilized nicotine. Examples of stabilized nicotine include nicotine-carrying substances such as nicotine supported on an ion exchange resin. Examples of ion exchange resins include weakly acidic cation exchange resins. Specific examples of nicotine-carrying ion exchange resins include a resin complex called nicotine polacrilex, which contains, for example, 10% by weight or more and 20% by weight or less of nicotine. The ion exchange resin used in nicotine polacrilex is a weakly acidic cation exchange resin. When nicotine polacrilex is used, the amount added to the oral composition is usually 0.5% by weight or more, preferably 1.0% by weight or more, and more preferably 2.0% by weight or more. On the other hand, from the viewpoint of flavor, the amount of nicotine polacrilex added to the composition is usually 15.0% by weight or less, preferably 12.0% by weight or less, and more preferably 10.0% by weight or less.

[0011] The nicotine-containing raw material may also be a tobacco material containing tobacco powder obtained by pulverizing tobacco leaves. The tobacco powder may contain shredded, finely divided, or fiber of dried tobacco leaf lamina, and may be prepared, for example, by the method described below. In the present invention, the tobacco leaf may contain mesophyll (lamina), leaf veins (stems), or roots. The tobacco material may contain, in addition to tobacco powder obtained primarily from tobacco leaf lamina, elements derived from the midrib or roots of tobacco leaves.

[0012] The particle size of the tobacco powder is not limited, but from the standpoint of improving compatibility in the oral cavity to enhance usability and improving the release of flavor components contained in the tobacco powder into the oral cavity, it is preferable that the powder has passed through a 1.2 mm mesh, and more preferably has passed through a 1.0 mm mesh.

[0013] The tobacco species used as the raw material for tobacco powder are not particularly limited, and examples include the genus Nicotiana, such as the flue-cured Nicotiana tabacum, the Burley variety, and the Brasilia variety of Nicotiana rustica. The same species can also be used for the tobacco material and tobacco leaves described below.

[0014] The tobacco powder is preferably prepared as follows. First, a base is added to tobacco powder obtained by grinding tobacco leaves and mixed. The base to be added may be potassium carbonate or sodium carbonate, and is preferably added as an aqueous solution. Furthermore, a pH adjuster such as sodium dihydrogen phosphate may be added, for example, to stabilize nicotine during the production of oral pouch products. After the addition of the base, the pH of the mixture is preferably adjusted to 8.0 to 9.0. The tobacco powder content in this mixture is preferably 60 to 90% by weight.

[0015] After the base is added, the mixture is heated, for example, under conditions such that the product temperature is 65 to 90°C, preferably 70 to 80°C, for 0.5 to 3 hours, preferably 0.8 to 2 hours. This sterilizes the tobacco powder. Heating can be carried out by either or both of steam injection heating and jacket heating. The pH of the mixture after heating is preferably 8.0 to 9.0, and the moisture content of the mixture after heating is preferably 10 to 50% by weight.

[0016] After heating, the resulting treated tobacco powder is dried by stopping steam injection as needed and heating only the jacket, followed by cooling at about 15 to 25°C for about 1 hour.

[0017] When a tobacco material containing tobacco powder is used, the amount of the tobacco material added to the oral composition is usually 0.001% by weight or more, preferably 0.01% by weight or more, and more preferably 0.05% by weight or more. On the other hand, from the viewpoint of flavor, the amount of the tobacco material added to the composition is usually 90% by weight or less, preferably 80% by weight or less, 70% by weight or less, 45% by weight or less, 40% by weight or less, or 30% by weight or less.

[0018] The nicotine-containing raw material may be a nicotine-containing extract obtained by extracting a nicotine-containing substance such as tobacco leaves.

[0019] Among the above embodiments, it is preferable to use a nicotine-containing substance from the viewpoints of accurate nicotine supply and ease of handling. Furthermore, when tobacco powder is added, the color of the oral composition or oral product tends to be the color of tobacco leaves. On the other hand, when a colorless nicotine-containing compound is used, it is possible to provide a white composition or oral product. This embodiment is advantageous for users who prefer white oral products. The above raw materials may be used alone or in combination of two or more.

[0020] The total nicotine content in the composition is not limited, but is usually 0.1 to 20.0% by weight from the viewpoint of user preference. Therefore, when a nicotine-containing raw material is used as a plant-derived alkaloid, the amount of the raw material is adjusted so that the total nicotine content falls within this range. When nicotine exists as an ion, the above content is the content of the nicotine ion. The nicotine content in the composition can be measured by gas chromatography-mass spectrometry (GC-MS), liquid chromatography (LC, UV detection), or the like.

[0021] (3) Inorganic porous material The inorganic porous material is preferably selected from the group consisting of silica, silicates, alumina, zeolites, hydroxyapatite, hydrotalcite, and combinations thereof. Among these, silica is preferred from the viewpoints of availability and minimal effect on flavor.

[0022] The content of the inorganic porous material in the composition is preferably 6% by weight or more. In the present invention, the content refers to the amount in an absolutely dry state unless otherwise specified. The lower limit of the content is preferably 10% by weight or more, more preferably 15% by weight or more. The upper limit of the content is not limited, but is usually 70% by weight or less, preferably 68% by weight or less, more preferably 65% by weight or less, in consideration of the limit of the amount of other raw materials that can be blended.

[0023] The average particle size of the inorganic porous material is preferably 60 to 500 μm. The average particle size of each material is the particle size at 50% cumulative volume (D50) in the particle size distribution determined by laser diffraction particle size distribution measurement. Laser diffraction particle size distribution measurement can be performed using, for example, a Mastersizer 3000 (manufactured by Malvern Panalytical). Unless otherwise specified, the average particle size refers to the particle size (D50) at which the volume cumulative value in the particle size distribution is 50%. When the average particle size is within the above range, it is easy to achieve the above range of bulk density. Furthermore, when the average particle size is below the above lower limit, it can cause powder leakage from the pouch used to package the oral composition or poor adhesion during sealing, which can cause discomfort to the user during use and reduce palatability. Furthermore, when the average particle size is excessively high, the user is more likely to perceive the roughness of the inorganic porous material particles, which can cause the product to have an unpleasant mouthfeel. From this viewpoint, the lower limit of the average particle size is preferably 60 μm or more, more preferably 100 μm or more, and the upper limit is preferably 500 μm or less, more preferably 300 μm or less.

[0024] (3) pH adjuster The composition contains a pH adjuster. The pH adjuster is not limited, and is preferably one that is permitted to be added to foods. Examples include sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, potassium phosphate, anhydrous sodium phosphate, sodium dihydrogen phosphate, and sodium citrate. Among these, sodium phosphate, potassium carbonate, or sodium dihydrogen phosphate is preferred from the viewpoint of the effect on the taste of the product and the product stability during storage. One type of pH adjuster may be used alone, or two or more types may be used in combination in any ratio.

[0025] (4) Gelling agents and gelling aids The composition may contain a known gelling agent or the like. The gelling agent alleviates the foreign body sensation caused by the nonwoven fabric or the like when the product is taken into the oral cavity, particularly at the initial stage of administration, and provides a favorable impression to the user. The gelling agent affects the bulk density of the composition. As the gelling agent, polysaccharides having a carboxyl group are preferred, such as carrageenan, pectin, gum arabic, xanthan, gellan gum, and tragacanth gum. Furthermore, carrageenan, pectin, and gellan gum are preferred because they are easily gelled in the presence of calcium ions and can form a junction zone between the carboxyl group and the cation to form a crosslinked structure. These may be used alone, or two or more may be used in any ratio. In particular, pectin or gellan gum is preferred as the gelling agent from the viewpoint of achieving a bulk density within the above range.

[0026] Examples of gelling aids include calcium ions, and their sources (gelling aids) are not limited, but include, for example, calcium halides (chlorides, etc.), citric acid, carbonates, sulfates, phosphates, and lactates. Among these, calcium lactate, calcium chloride, and calcium phosphate are preferred, with calcium lactate being particularly preferred, from the standpoints of their minimal effect on taste, high solubility, and pH after dissolution. These may be used alone, or two or more may be used in combination in any ratio.

[0027] Examples of gelling aids other than calcium ions include metal ions such as magnesium, silver, zinc, copper, gold, and aluminum, which can bond with gelling agents via ionic bonds like calcium ions, as well as ions of cationic polymers. Sources of these (other gelling aids) include, for example, halide salts (chlorides, etc.) of these metal ions, citric acid, carbonates, sulfates, phosphates, and cationic polymers. These may be used alone or in combination of two or more in any ratio.

[0028] (5) Release agent The composition may contain a known mold release agent. However, since the inorganic porous material, particularly silica, also functions as a mold release agent, the composition does not necessarily contain any mold release agent other than the inorganic porous material.

[0029] (6)Water The water content (moisture content) in the composition is 10 to 70% by weight from the viewpoint of ease of production of the composition. Furthermore, from the viewpoints of improving the production efficiency of the composition, improving anti-caking properties, suppressing stickiness, etc., the lower limit of the water content is preferably 30% by weight or more, more preferably 45% by weight or more, and the upper limit is preferably 60% by weight or less, more preferably 50% by weight or less. The water content may be 40% by weight or less, 30% by weight or less, or even 20% by weight or less. The water content can be adjusted by adjusting the amount of water added or by performing a heating treatment or drying treatment during the production stage. The water content of the composition is appropriately adjusted depending on the type of product (moist or dry). For example, in the case of a moist type, the water content is usually 20 to 60% by weight, preferably 30 to 50% by weight. On the other hand, in the case of a dry type, the water content is usually 5 to 20% by weight, preferably 10 to 15% by weight.

[0030] The water content of the composition (moisture content) can be measured using a heat-drying moisture meter (e.g., HB 43-S manufactured by METTER TOLEDO). For measurement, a sample is placed in a designated container and heated to a temperature of 100°C. The measurement is terminated when the change in weight is 1 mg or less in 60 seconds, and the moisture content is calculated from the weighed values before and after heating.

[0031] (7) Other The composition may contain other substances in addition to those described above. Examples of other substances include flavorings, sweeteners, humectants, bitterness suppressants, and emulsifiers. The content of these substances is not limited, and the formulation can be adjusted appropriately depending on the product design.

[0032] 1)Fragrance The flavoring agent is not limited, and examples thereof include menthol, tobacco leaf extract, natural plant flavorings (e.g., cinnamon, sage, herbs, chamomile, kudzu, sweet tea, cloves, lavender, cardamom, cloves, nutmeg, bergamot, geranium, honey essence, rose oil, lemon, orange, cinnamon bark, caraway, jasmine, ginger, coriander, vanilla extract, spearmint, peppermint, cassia, coffee, celery, cascarilla, sandalwood, cocoa, ylang-ylang, fennel, anise, licorice, St. John's bread, plum extract, peach extract, etc.), sugars (e.g., glucose, fructose, isomerized sugar), , caramel, honey, molasses, etc.), cocoa (powder, extract, etc.), esters (e.g., isoamyl acetate, linalyl acetate, isoamyl propionate, linalyl butyrate, etc.), ketones (e.g., menthone, ionone, damascenone, ethyl maltol, etc.), alcohols (e.g., geraniol, linalool, anethole, eugenol, etc.), aldehydes (e.g., vanillin, benzaldehyde, anisaldehyde, etc.), lactones (e.g., γ-undecalactone, γ-nonalactone, etc.), animal fragrances (e.g., musk, ambergris, civet, castoreum, etc.), and hydrocarbons (e.g., limonene, pinene, etc.). One type of fragrance may be used alone, or two or more types may be used in combination in any ratio.

[0033] 2) Sweeteners Examples of sweeteners include, but are not limited to, sugar alcohols such as xylitol, maltitol, and erythritol; and acesulfame potassium, sucralose, and aspartame. Sugar alcohols are preferred from the viewpoint of taste control. One type of sweetener may be used alone, or two or more types may be used in any ratio.

[0034] The type of sugar alcohol is not particularly limited, and examples thereof include xylitol, maltitol, erythritol, sorbitol, mannitol, and lactitol. Among these, maltitol is preferred from the viewpoint of imparting a good flavor. These substances may be used alone or in combination of two or more kinds in any ratio.

[0035] The sugar alcohol content in the composition (total content when two or more types of sugar alcohols are contained) is not limited, but from the viewpoint of flavor regulation, it is usually 1% by weight or more, preferably 5% by weight or more, and more preferably 10% by weight or more. The upper limit is usually 80% by weight or less, preferably 70% by weight or less, and more preferably 60% by weight or less.

[0036] 3) Bitterness suppressant The bitterness suppressing agent is not limited, but may be, for example, soybean lecithin. Soybean lecithin is a phospholipid, specifically, phosphatidylcholine, phosphatidylethanolamine, phosphatidic acid, etc. As the bitterness suppressing agent, one type may be used alone, or two or more types may be used in combination in any ratio.

[0037] 4) Moisturizer The moisturizing agent is not limited, but examples thereof include polyhydric alcohols such as glycerin and propylene glycol. From the viewpoint of product preservation, glycerin is preferred. As the moisturizing agent, one type may be used alone, or two or more types may be used in any ratio.

[0038] 5) Emulsifiers, surfactants The emulsifier is not limited, and examples thereof include emulsifiers added to foods. Examples of emulsifiers include one or more selected from the group consisting of sucrose fatty acid esters, organic acid glycerin fatty acid esters, polyglycerin fatty acid esters, and lecithin. Examples of sucrose fatty acid esters include sucrose palmitate ester and sucrose stearate ester. Examples of organic acid glycerin fatty acid esters include succinic acid glycerin fatty acid ester and diacetyltartaric acid glycerin fatty acid ester. Examples of polyglycerin fatty acid esters include decaglycerin fatty acid ester. The content of the emulsifier in the composition is preferably such that the total content with the polyglycerin fatty acid ester falls within the above-mentioned range for the polyglycerin fatty acid ester content.

[0039] The degree of polymerization of glycerin in the polyglycerin fatty acid ester is preferably 2 to 10. The polyglycerin fatty acid ester functions as an emulsifier. Therefore, by including the polyglycerin fatty acid ester, the components of the composition are maintained in a uniform mixed state, and flavor components are stabilized, thereby improving the flavor of the composition. Furthermore, the polyglycerin fatty acid ester imparts appropriate viscosity to the composition and binds the components together, thereby reducing the dryness of the composition and improving the feel and flavor of the composition. Furthermore, even if the composition is a dry type with a low water content (moisture content), scattering of the composition can be prevented when the composition is filled into an outer packaging material such as a pouch. Thus, by including the polyglycerin fatty acid ester in the composition, production efficiency, such as work efficiency and yield, can be improved in the production of oral care products.

[0040] The polyglycerol fatty acid ester is a fatty acid ester of a dehydration condensation product of glycerol, and the degree of polymerization of glycerol is usually 2 or more, and may be 3 or more, and is usually 10 or less, and may be 8 or less.

[0041] The fatty acid ester group (RCOO- group) of the polyglycerol fatty acid ester is derived from a fatty acid. The fatty acid is not limited and may be a saturated fatty acid or an unsaturated fatty acid. From the viewpoints of good flavor and production efficiency, the number of carbon atoms in the fatty acid is usually 10 or more, preferably 12 or more, more preferably 14 or more, and even more preferably 16 or more, and is usually 30 or less, preferably 26 or less, more preferably 22 or less, and even more preferably 20 or less. The fatty acid may have a substituent or may be unsubstituted.

[0042] Furthermore, the number of fatty acid ester groups in one molecule of polyglycerol fatty acid ester is not limited as long as the structure allows the polyglycerol fatty acid ester to function as an emulsifier, and can be appropriately selected depending on the degree of polymerization of glycerol and the number of hydroxyl groups derived from glycerol. A structure that can function as an emulsifier is a structure that has both a fatty acid moiety that serves as a lipophilic group and a polyhydric alcohol moiety that serves as a hydrophilic group. Specifically, the number of fatty acid ester groups in one molecule of polyglycerol fatty acid ester is usually one or more. Furthermore, the number of hydroxyl groups derived from glycerol is also one or more.

[0043] The degree of polymerization of glycerin and the type and number of fatty acid ester groups in the polyglycerol fatty acid ester can be any combination of those described above. More specifically, the alcohol component of the polyglycerol fatty acid ester may be diglycerol, triglycerol, tetraglycerol, pentaglycerol, hexaglycerol, heptaglycerol, octaglycerol, nonaglycerol, or decaglycerol. The acid component of the polyglycerol fatty acid ester may be a fatty acid such as lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, or α-linolenic acid. The polyglycerol fatty acid ester may be a monoester, diester, triester, tetraester, pentaester, or the like. One type of polyglycerol fatty acid ester may be used alone, or two or more types may be used in any ratio.

[0044] From the viewpoint of good flavor and ease of production, the polyglycerol fatty acid ester is preferably one or more selected from diglycerol mono-fatty acid esters and decaglycerol fatty acid esters. The diglycerol mono-fatty acid ester is preferably selected from the group consisting of diglycerol monolaurate, diglycerol monomyristate, diglycerol monopalmitate, diglycerol monostearate, and diglycerol monooleate, and more preferably diglycerol monooleate. The decaglycerol fatty acid ester is preferably selected from the group consisting of decaglycerol laurate, decaglycerol myristate, decaglycerol palmitate, decaglycerol stearate, and decaglycerol oleate, and more preferably selected from the group consisting of decaglycerol monolaurate, decaglycerol monomyristate, decaglycerol monopalmitate, decaglycerol monostearate, and decaglycerol monooleate.

[0045] The content of polyglycerol fatty acid ester in the composition (when two or more types of polyglycerol fatty acid esters are contained, the total content thereof) is not limited, but from the viewpoints of obtaining a good flavor and improving production efficiency, it is usually 0.1% by weight or more, preferably 0.2% by weight or more, more preferably 0.3% by weight or more, and even more preferably 0.5% by weight or more. Furthermore, from the viewpoint of imparting an appropriate viscosity to the composition, the content of the polyglycerol fatty acid ester is usually 20.0% by weight or less, preferably 15.0% by weight or less, more preferably 10.0% by weight or less, and even more preferably 8.0% by weight or less.

[0046] The HLB value of the polyglycerol fatty acid ester is not limited, but from the viewpoint of obtaining a good flavor and improving production efficiency, it is usually 6.0 or more, preferably 7.0 or more, and usually 20.0 or less, preferably 18.0 or less, more preferably 16.0 or less.

[0047] (8) Characteristics of the composition 1) pH The pH of the composition is not limited, but from the viewpoint of the effect on taste, it is usually 7.0 or higher, preferably 7.5 or higher, more preferably 8.0 or higher, and usually 10.0 or lower, preferably 9.5 or lower, more preferably 9.0 or lower. The pH is measured at 25°C.

[0048] The pH of the composition at a measurement temperature of 25°C can be measured using a pH analyzer (e.g., HORIBA's LAQUA F-72 flat ISFET pH electrode) by adding 20 mL of water to 2 g of the composition, shaking for 10 minutes, and measuring the supernatant. Calibration of the instrument is preferably performed using three-point calibration, for example, using a phthalic acid pH standard solution (pH 4.01), a neutral phosphate pH standard solution (pH 6.86), and a borate pH standard solution (pH 9.18) (all from Wako Pure Chemical Industries, Ltd.).

[0049] (9) Method for producing the composition The composition may be produced by any method, but is preferably produced by mixing nicotine, an optional base material, and the above-mentioned components. The mixing can be carried out by putting all the raw materials into a mixer and mixing them.

[0050] In a preferred production method, the base material, nicotine, and, if necessary, water and other substances (sweeteners, flavors, humectants, etc.) are first mixed to obtain a first mixture. Heat may be applied at this time. The order in which the ingredients are mixed is not limited; they may be added to a mixer in any order or simultaneously and mixed, or the solid ingredients may be mixed uniformly, and then the liquid ingredients may be added and further mixed. From the viewpoint of workability, the latter embodiment is preferred.

[0051] To the mixture obtained as described above, an aqueous solution containing a pH adjuster, a sweetener such as acesulfame potassium, a flavoring such as menthol, a bitterness suppressant such as soybean lecithin, and a humectant such as glycerin can be added as needed (additive addition step). The additives may be added in solid form or as an aqueous solution dissolved in water. When added as an aqueous solution, they may be dissolved in a predetermined amount of water in advance so as to achieve the final moisture content of the oral product.

[0052] 2. Oral pouch products Oral products are used by being held in the mouth. An oral pouch product is a product that contains a composition (also called a base material or a filler) in a sealed water-insoluble packaging material (also called a pouch), and saliva penetrates through the pouch to dissolve the ingredients in the composition contained in the pouch, which can then be carried through the pouch and into the oral cavity.

[0053] (1) Pouch The pouch can be made of any known material, as long as it can package the filling, is insoluble in water, and is permeable to liquids (water, saliva, etc.) and water-soluble components in the filling. Examples of pouch materials include cellulose-based nonwoven fabrics, and commercially available nonwoven fabrics may also be used. A pouch product can be produced by forming a sheet made of such a material into a bag shape, filling it with the filling, and sealing it by means of heat sealing or the like.

[0054] The basis weight of the above sheets is not particularly limited, and is usually 12 gsm (g / m 2 The thickness of the sheet is not particularly limited, but is usually 100 μm or more and 300 μm or less, and preferably 175 μm or more and 215 μm or less.

[0055] A water-repellent material may be applied to at least one of the inner and outer surfaces of the pouch. A water-repellent fluororesin is preferably used as the water-repellent material. Specifically, an example of this type of water-repellent fluororesin is Asahi Guard (registered trademark) manufactured by Asahi Glass Co., Ltd. Water-repellent fluororesins are applied to packaging materials for foods and products containing fats and oils, such as confectioneries, dairy products, prepared foods, fast food, and pet food. Therefore, this type of water-repellent fluororesin is safe to apply to pouches placed in the oral cavity. The water-repellent material is not limited to fluororesins, and may be, for example, a water-repellent material such as paraffin resin, silicone resin, or epoxy resin.

[0056] The pouch may contain any ingredient, such as a scent- or taste-adjusting material, a flavoring, an additive, a tobacco extract, or a coloring. The manner in which these ingredients are contained is not limited, and examples include coating the pouch surface, impregnating the pouch, or, if the pouch is made of fiber, incorporating the ingredients into the fiber.

[0057] The appearance of the pouch is also not limited. The pouch may be opaque, translucent, or transparent. Translucent or transparent pouches allow the contents to be seen through.

[0058] Regarding the size of the oral pouch product before use, the upper limit of the long side is preferably 25 mm or less, more preferably 15 mm or less. The lower limit of the short side is preferably 10 mm or more or 13 mm or more, and the upper limit is preferably 20 mm or less or 17 mm or less. The dimensions of the long side and short side do not include the edge of the pouch. The weight ratio of the filling to the total weight of the oral pouch product is not limited, but is usually 80 wt% or more, preferably 85 wt% or more, more preferably 90 wt% or more, and usually 99 wt% or less, preferably 97 wt% or less, more preferably 95 wt% or less.

[0059] (2) Filling The oral pouch product is filled with the composition as a filler. The amount of the filler per oral pouch product is preferably 0.4 to 1.5 g.

[0060] (3) Manufacturing method of oral pouch products An oral pouch product can be produced by packaging the composition in an outer packaging material (packaging process). The packaging method is not limited, and known methods can be used. For example, known methods can be used, such as a method in which the composition is placed in a bag-shaped nonwoven fabric and then sealed. In the packaging process, additional water may be added as desired after sealing (water addition process). For example, if the water content of the final composition is 50% by weight and the water content of the filled composition is 15% by weight, the remaining 35% by weight of water is added. [Example]

[0061] [Example 1] Preparation of oral composition 100.0 g of silica (Evonic, SIPERNAT 2200) as a base material, 3.87 g of nicotine, 45.1 g of anhydrous sodium phosphate aqueous solution, 4.79 g of anhydrous citric acid aqueous solution, 14.03 g of sodium chloride aqueous solution, and 23.4 g of acesulfame K aqueous solution were added and mixed until uniform, yielding Mixture A. The resulting Mixture A was jacket heated (can wall temperature: 100°C). It was then cooled for 30 minutes at an ambient temperature of 20°C, yielding Mixture B (water content after cooling: 11%). After cooling, Mixture B was added with 67.7 g of tripotassium phosphate aqueous solution, 28.5 g of trisodium phosphate aqueous solution, 20 g of gellan gum aqueous solution, 7.5 g of flavor, and other ingredients to yield 270 g of an oral composition (water content: 44.06 wt %, pH: 8.46).

[0062] [Example 2] An oral composition was prepared in the same manner as in Example 1, except that 7.5 g of distilled water was mixed in place of the flavoring.

[0063] [Example 3] An oral composition was produced in the same manner as in Example 1, except that 25.0 g of powdered cellulose (VITACEL L00, manufactured by Rettenmeyer) and 75.0 g of the silica were mixed and used as the base material.

[0064] [Example 4] An oral composition was produced in the same manner as in Example 1, except that 35.0 g of the powdered cellulose and 66.0 g of the silica were mixed and used as the base material.

[0065] [Example 5] An oral composition was produced in the same manner as in Example 1, except that 50.0 g of the powdered cellulose and 51.0 g of the silica were mixed and used as the base material.

[0066] [Example 6] An oral composition was produced in the same manner as in Example 1, except that 76.0 g of the powdered cellulose and 26.0 g of the silica were mixed and used as the base material.

[0067] [Comparative Example 1] An oral composition was produced in the same manner as in Example 1, except that 100.0 g of granular regenerated cellulose (Viscopal Mini, manufactured by Rengo Co., Ltd.) was used as the base material.

[0068] Comparative Example 2 An oral composition was produced in the same manner as in Example 1, except that 100.0 g of the granular regenerated cellulose was used as the base material and 7.5 g of distilled water was added instead of the flavoring agent.

[0069] Comparative Example 3 An oral composition was produced in the same manner as in Example 1, except that 81.0 g of the powdered cellulose and 20.0 g of the silica were mixed and used as the base material. Table 1 shows the composition and physical properties of the composition.

[0070] [Table 1]

[0071] [Example 7] 0.4 g of the composition obtained in Example 1 was taken and packaged in a known pouch to produce an oral product.

[0072] [Example 8] 1.0 g of the composition obtained in Example 1 was taken and packaged in a known pouch to produce an oral product.

[0073] Comparative Example 4 0.4 g of the composition obtained in Example 1 was taken and packed in a known pouch to produce an oral product.

[0074] Comparative Example 5 0.65 g of the composition obtained in Example 1 was taken and packed in a known pouch to prepare an oral product. Table 2 shows the sizes of the prepared oral products.

[0075] [Table 2]

[0076] When Example 7, Example 8, Comparative Example 4, and Comparative Example 5 were subjected to a sensory evaluation by seven expert panelists, oral products such as those of Example 7 and Example 8 tended to be more palatable because they fit easily into gaps in the oral cavity and were less likely to cause a foreign body sensation. On the other hand, the products of Comparative Examples 4 and 5 were larger in size, and therefore tended to be less palatable compared to Example 7 and Example 8 when used in gaps in the oral cavity.

[0077] By controlling the bulk density of the composition of the present invention, it is possible to encapsulate a small amount of the composition and design a product that achieves a sufficient taste effect. In particular, with pouch-type oral products, if the product is large, the user may be more likely to perceive the foreign body sensation of the nonwoven fabric packaging, which can reduce palatability. In other words, the oral composition of the present invention is useful in that it increases the freedom of product design and allows for the provision of products that do not interfere with the user's palatability. Each physical property was measured as follows.

[0078] <Loose bulk density> The measurement was performed in accordance with Japanese Pharmacopoeia 3.01. Specifically, the powder composition of the above example was allowed to fall freely from a hopper placed above it, and the drop was measured at a height of 100 cm. 3 The powder was allowed to flow down into the measuring container until it overflowed. The powder on the top and sides of the measuring container was scraped off, and the mass of the composition powder was measured. Based on the measured mass of the powder, the loose bulk density was calculated using the following formula. Loose bulk density (g / cm 3 ) = Mass of composition powder (g) / Volume of measuring container (cm 3 )

[0079] <Moisture content> Measurements were performed using a heat-drying moisture meter (Metter Toledo: HB 43-S). The sample was placed in a designated container and heated to a temperature of 100°C. The measurement was stopped when the change in weight was 1 mg or less in 60 seconds, and the moisture content was calculated from the weighing values before and after heating.

[0080] <ph> Using a pH analyzer (HORIBA, Ltd.: LAQUA F-72 flat ISFET pH electrode), 20 ml of water was added to 2 g of the composition, and the mixture was shaken for 10 minutes, and the supernatant was measured. The instrument was calibrated using, for example, a three-point calibration using a phthalic acid pH standard solution (pH 4.01), a neutral phosphate pH standard solution (pH 6.86), and a borate pH standard solution (pH 9.18) (all from Wako Pure Chemical Industries).< / ph>

Claims

1. Contains nicotine and has a bulk density of 0.4 g / cm ３ The oral composition is as described above.

2. The oral composition of claim 1 , comprising an inorganic porous substrate.

3. The oral composition according to claim 2 , wherein the content of the inorganic porous substrate is 6% by weight or more.

4. the inorganic porous material is selected from the group consisting of silica, silicates, alumina, zeolites, hydroxyapatite, hydrotalcite, and combinations thereof; The oral composition according to claim 2 or 3.

5. The oral composition according to any one of claims 2 to 4, wherein the inorganic porous substrate has an average particle size of 60 to 500 µm.

6. The oral composition according to any one of claims 1 to 5, wherein the water content is 10 to 70 wt%.

7. The oral composition according to any one of claims 1 to 6, A packaging material for packaging the oral composition; An oral pouch product comprising:

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