System for processing health indicator values ​​of a patient - Patent application

Abstract

The present invention relates to a system for processing health indicator values ​​to determine a numerical score representative of a patient's overall health, the system comprising a database (1) containing a series of values ​​of indicators of different aspects of health calibrated using standardized values. A number of input means (2A, 2B, 2C) are each associated with at least one patient. An equal number of intermediate servers (7) are each associated with the input means (2A, 2B, 2C) of one or more patients and communicate with a master server (8) comprising the calculation units (4) of all intermediate servers. The raw data of indicators of the different aspects of the patient's health received by the input means (2A, 2B, 2C) are calibrated and transmitted to the master server (8) and the calculated scores of said data are stored on a display device (5), for example a smartphone associated with the input means of the patients.

Description

[Technical field]

[0001] The object of the present invention is a system for processing the health index values ​​of at least one patient to determine, for each patient, a numerical score representative of the patient's overall health in order to assist that person in restoring, optimizing and maintaining his / her health and to ensure and increase his / her well-being and longevity. [Background technology]

[0002] The applicant's WO2016110734 already discloses a method for assessing a score representative of a patient's health, based on the following considerations:

[0003] The ready availability of scientific research results has tremendously accelerated our understanding of human physiology. Despite this, patients are still too often treated according to incorrect or incomplete concepts. This method relies solely on recent, validated research to provide optimal care to patients.

[0004] Health is the result of a balance between two parts of the body: the gastrointestinal system or digestive brain and the nervous system or brain.

[0005] The digestive system must provide energy, essential nutrients, vitamins and trace elements, and act as a protective barrier against the entry of unwanted invaders, much like the skin, the mucous membranes of the lungs and the blood-brain barrier. It is in continuous communication with the brain via the enteric nervous system and a host of hormones, lipoproteins, interleukins and other substances, some of which are still unknown.

[0006] The digestive interface must be considered in its entirety. This includes the thousands of species of bacteria found in the human digestive tract. They have lived symbiotically with generations of individuals for thousands of years. Each individual feeds on the results of its own metabolism. They provide about 50% of the essential ingested nutrient content of each individual. They also produce many lipoproteins that can send information to the brain. They play a fundamental role in immune function and, above all, in the development of inflammation that can affect the entire body. The latest scientific evidence clearly demonstrates a link between the gut microbiota and certain diseases such as obesity and type 2 diabetes. Ensuring the quality of an individual's gut microbiota is fundamental to maintaining good health.

[0007] The intestinal mucosa acts as a real barrier. It consists of juxtaposed cells held together by tight junctions. The integrity of these links is essential. The intestinal mucosa is the border between the outside and the inside of the body. It is therefore not surprising that more than half of an individual's immune defenses are located along the digestive tract. When a foreign bacterium or protein penetrates this protective layer, the immune system must prevail to eliminate it from the individual. This can mean a considerable expenditure of energy for the body. That energy is no longer available for other functions. It is therefore crucial to ensure that the intestinal cells (enterocytes) receive optimal nutrition and that nothing attacks the tight junctions.

[0008] The brain is the driving force, regulator and coordinator of all essential functions. To function properly, it must be well protected by the digestive brain and constantly activated. Physical activity, which is movement through the stimulation of cerebellar neurons, is the most important activation. Other stimuli, such as vision, hearing, taste and touch, also play this role.

[0009] During evolution, the brain has changed. Depending on the developmental stage, different zones can be distinguished. The primitive brain, known as the nervous system or reptilian system, is the most important area with regard to health. It manages essential functions and ensures the proper regulation of the different cycles that delimit the day of an individual. The other zones have a regulatory effect on the reptilian brain.

[0010] It is therefore essential to assess the function of all these zones in order for an individual to know his or her state of health. This is made possible by new discoveries in the field of functional neurology. It is therefore possible to stimulate or inhibit certain brain areas in order to modify their regulatory effect on the nervous system.

[0011] In addition, a marker of cell damage is well known: oxidative stress.

[0012] Furthermore, doctors and patients alike are increasingly finding themselves with fewer available resources, and while appointments can still be made when one falls ill, follow-up appointments are becoming increasingly complicated.

[0013] Today, people have applications on their smartphones to track, for example, their sports performance or a night's sleep, as well as medical records kept at each doctor's visit.

[0014] The goal of the present invention is a system for processing the health index values ​​of at least one patient to determine, for each patient, a numerical score representative of the patient's overall health in order to assist that person in restoring, optimizing and maintaining his or her health and to ensure and increase his or her well-being and longevity.

[0015] The present invention relates to a system for processing patient health index values ​​to determine, for each individual patient of a plurality of patients, a numerical score representative of the patient's overall health, the system comprising a database comprising a set of index values ​​for different aspects of health calibrated using standardized values, means for inputting a set of patient health index data among the standardized values, a unit for storing the data received by the inputting means, and a unit for calculating a numerical score representative of the patient's overall health according to a weighting of the patient's health index data values.

[0016] Such a system is derived from implementation of the method described in WO2016110734 through generalization of the health index values, their groupings, and the weightings applied, however the method of WO2016110734 described below involves defined health index values, their groupings, and specific weightings. Summary of the Invention

[0017] One object of the present invention is to provide such a system which is able to implement the method of WO2016110734 by calculating the health score in a simpler manner and in particular by allowing each patient to access the score more quickly, which is particularly advantageous when the system treats a large number of patients.

[0018] It is a further object of the present invention to provide such a system which is capable of implementing other methods using other health index values ​​and according to other weightings of the patient's health index values.

[0019] According to the invention, the system comprises a number of input means, each associated with at least one patient, a number of intermediate servers, each intermediate server associated with the input means of one or more patients, and a master server for all intermediate servers, the master server comprising a calculation unit. The electronic sensor device comprises at least one sensor associated with the input means for receiving raw data indicators of different aspects of the patient's health from these input means. Calibration means integrated in the input means, the intermediate server or the master server are arranged to calibrate the raw sensor data according to calibrated and standardized values ​​from the database and to transfer the calibrated values ​​to a storage unit arranged to transmit the calibrated data to the calculation unit of the master server.

[0020] Each intermediate server forms a platform with the master server for exchanging health score data calculated by the calculation unit of the master server, the data exchange platform being arranged to store an overall health score of each patient in a display device associated with a patient-specific input means, the calculation unit of the master server being arranged to instantaneously calculate a patient's health score each time the input means integrates patient health indicator data whose value influences the calculation of the health score, thereby automatically updating the overall health score of each patient stored in the display device.

[0021] The applicant's WO2016110734 defines a method for determining a numerical score representative of a patient's overall health based on a set of indicators related to the patient's overall health status and stored in a database, which method can be implemented by the system of the present invention. The method comprises the following steps: In an initial calibration step, a database is established that is combined with information about the patient's overall health status from a set of indicators regarding the patient's overall health status, including an indicator regarding oxidative stress, an indicator regarding digestive brain function, an indicator regarding reptilian brain function, and an indicator regarding the patient's physical performance, and each individual indicator is assigned a numerical value between 0 and 10; - The statistical analysis of this database - establishing a score ranging from 0 to 10 for each of the patient indicators as a function of the measurement of the patient's health status indicator relative to a reference value; -Four groups of indicators stored in the database, namely: The group of oxidative stress indicators, which is group 1 below, A group of indicators related to digestive brain function, hereafter referred to as group 2, A group of indicators of reptilian brain function, hereafter referred to as group 3, and carried out to establish a group of indicators related to the patient's physical capabilities combined with information about the patient's general health status, hereinafter group 4, For each patient, a value is assigned to each group from 0 to 100 according to the patient's index score, and the value of each group is related to the 10 * (the sum of the scores from 0 to 10 for each of the N indicators in the indicator group considered to calculate the value of each group) / N, A health score S specific to the patient's overall health, on a scale of 0 to 100, is then calculated using the following formula: S = (Σ1 * (Group 1 value)+2 * (Group 2 value)+2 * (Group 3 values) +3 * (Group 4 values)) / 8.

[0022] Numeric scores are determined on a scale of 0 to 100. The value of each indicator varies from 0 to 10, while the value of each group also varies from 0 to 100.

[0023] In a preferred embodiment of the method, Group 1 value is determined using scores related to digestive analysis, oxidized LDL (Low Density Lipoprotein) value, HOMA (homoestasis model assessment) index, selenium value, ferritin value, and zinc value. Group 1 gives a value for oxidative stress.

[0024] Oxidative stress is the root of many chronic diseases, where highly reactive molecules linked to oxygen constantly damage our most important molecules and ultimately make us sick. The paradox is that these highly reactive molecules, known as free radicals, have important biological functions, especially in cell signaling, and are useful to the individual. In excess, they can also attack all the components of the living body, promoting cataracts, cancer, coronary heart disease, diabetes, kidney failure, Alzheimer's disease, Parkinson's disease, and other chronic diseases. In theory, these free radicals are neutralized or countered by the body's own protective mechanisms, called antioxidants. Today, antioxidants are key to longevity and have emerged as our allies in the fight against modern diseases. They are protective elements that intervene by scavenging free radicals. Oxidative stress, whether temporary or persistent, can lead to physical or nervous fatigue, as well as eating disorders.

[0025] In one embodiment of the method, the Group 2 value is determined using scores related to digestive analysis, CRP (C-reactive protein) value, HOMA index, and omega-6 / omega-3 ratio value. Group 2 provides a value for digestive inflammation.

[0026] In one embodiment of the method, the Group 3 value is determined using scores linked to health questionnaires, values ​​linked to measurements of perceived time, homocysteine ​​values, Omega-3 Index values, scores linked in particular to night-time cardiac variability parameters, values ​​of the root mean square of the successive differences in heart rate, values ​​of the LF / HF (low frequency / high frequency) ratio reflecting the overall sympathovagal balance, values ​​of the restorative sleep index, and values ​​linked to measurements taken on the total activity of the autonomic nervous system. Group 3 gives a value for brain function.

[0027] In particular, nervous system activity is measured through cardiac variability during exercise and over a 24-hour period, making it possible to measure the quality of sleep and the individual's ability to recover. This measurement is essential for the follow-up of the patient. The deeper the program, the greater the need for improvement.

[0028] In one embodiment of the method, the Group 4 value is determined in particular by a score linked to a health questionnaire, the results of which are analyzed and weighted for motor tests for speed or power, measurements of cardiac amplitude, scores linked to speed tests, and root mean square values ​​of consecutive heart rate differences of 10 or less, somatosensory tests, visual tests, vestibular tests, ferritin values, HOMA index, zinc values, selenium values, CRP values, and immune questionnaire values. Group 4 gives a value for general health. This is because a complete examination based on a thorough functional neurological examination makes it possible to determine the level of functioning of the nervous system and the control capacity of higher cortical areas. The individual functions and interactions of the three main sensory systems, peripheral, vestibular and ocular, are also examined. We also evaluate the adaptation of the motor system, the visual ability when the head is moving, and the functional ability of the lower limb joints. Each index has a value from 0 to 10.

[0029] For example, the Group 1 value can be determined using the following formula: Group 1 Value = Σ(((3 * Digestive analysis value) + (3 * Oxidized LDL value) +2 * (Zinc value + Selenium value) + HOMA index value + Ferritin value) * 10) / 12.

[0030] The Group 2 value can be determined using the following formula: Group 2 value = Σ(((5 * CRP value) + (3 * Digestive Analysis Value) +2 * (Omega 6 / Omega 3 value) + HOMA index value) * 10) / 11.

[0031] The Group 3 Value can be determined using the following formula: Group 3 Value = Σ(((3 *Health Questionnaire Value) + (4 * Perceived Time Measure) + (5 * Autonomic nervous system measurements) + (3 * Cardiac variability parameter nighttime value HF) + (3 * Cardiac variability parameter nighttime value LF) + (3 * Homocysteine ​​root mean square value (LF) + (3 * Root mean square value of consecutive heart rate differences) + (2 * Homocysteine ​​value) + (LF / HF ratio value) + Omega-3 index value + Sleep recovery index value) * 10) / 26.

[0032] Finally, the Group 4 value can be determined using the following formula: Group 4 value = Σ(((3 * Health Questionnaire Value) + (5 * Speed ​​Effort Test Value) + (5 * Power Effort Test Value) + (4 * Heart amplitude value) + (4 * Speed ​​test value and consecutive heart rate difference root mean square value) + (2 * Somatosensory test value) + (2 * Visual test value) + (3 * Vestibular test value) + (2 * Ferritin value) + Homa index value + Zinc value + Selenium value + (4 * CRP value) + (2 * Immunoassay value) * 10) / 39.

[0033] In summary, the method of WO2016110734 determines a numerical score representative of a patient's overall health based on a weighting of the patient's health index values.

[0034] To implement the method described in WO2016110734, the calculation unit calculates scores that are stored in a storage unit accessible to the master server, the intermediate server, or the electronic capture device.

[0035] In one embodiment of the invention, each of the input means comprises a keyboard for manual data entry as well as an input for computerized data.

[0036] In this embodiment, each intermediate server and computing unit processes each patient's data separately.

[0037] Also according to this embodiment, each of the input means comprises a device for storing and displaying the overall health score of each patient.

[0038] In one embodiment, the calculation unit is parameterized to calculate the health score according to at least three, preferably at least four parameters representing different health index values.

[0039] According to this embodiment, the calculation unit is configured to calculate a health score according to weighted values ​​of four parameter groups representing different values ​​of the health index, corresponding respectively to the patient's oxidative stress index, digestive brain function, reptilian brain function, and general health status.

[0040] Further according to this embodiment, the calculation unit is configured to calculate the health score by considering the values ​​of the heart amplitude, the perception time and the Omega-3 index.

[0041] In one embodiment, the electronic sensing device of the input means is a smartphone, a connected watch, and / or a heart rate belt.

[0042] In another embodiment, the input means with electronic sensor devices with intermediate servers are grouped together in a single device or integrated into multiple devices grouped together in the same location, typically a doctor's office.

[0043] Therefore, the system according to the invention has as many input means as there are physicians, each input means being equipped with an intermediate server, and each physician monitoring one or more patients.

[0044] The characteristics of the invention will become apparent on reading and with reference to the schematic drawings in which some embodiments are given by way of example only and not of limitation. [Brief description of the drawings]

[0045] [Figure 1] FIG. 1 is a schematic diagram of a portion of a system illustrating tracking of a patient through their smartphone, an intermediate server, and a master server. [Diagram 2] FIG. 1 is a schematic diagram of a system illustrating the monitoring of five patients via a smartphone, two intermediate servers, and a master server, respectively. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0046] Figure 1 shows part of a system for processing a patient's health index values ​​to determine a numerical score representative of the patient's overall health. The system comprises a database 1 containing a set of health index values ​​calibrated using standardized values, means 2A, 2B, 2C for inputting a set of patient's health index data among the standardized values, units 3A, 3B for storing the data received by the input means 2A, 2B, 2C, and a unit 4 for calculating a numerical score representative of the patient's overall health according to a weighting of the patient's health index data values.

[0047] In this embodiment, the database 1 and storage unit 3A are located on the master server 8 on which the computing unit 4 is located.

[0048] In this embodiment, the input means 2C comprises a smartphone 5 having a sensor 6 arranged to receive raw health indicator data from the patient and to calibrate this raw data using electronic components according to standardized database values.

[0049] In this embodiment, the smartphone 5 is connected to a connected watch 9 and a heart rate belt 10.

[0050] Storage unit 3B is integrated into intermediate server 7, while storage unit 3A is integrated into master server 8 and computation unit 4 is fully integrated into master server 8.

[0051] Database 1 comprises a group of quantified indicators as presented in WO2016110734, e.g. regarding oxidative stress, regarding digestive brain function, regarding reptilian brain function and regarding the physical performance of the patient combined with information about the patient's overall health status.

[0052] The various input means 2A, 2B, 2C correspond either to the keyboard of the master server 8, to the keyboard of the intermediate server 7 or to the keyboard of the smartphone 5. These various input means are arranged to input the raw values ​​of all health indicators according to the groups stored in the database 1. For example, the data entered via the smartphone 5 or the intermediate server 7 is calibrated by the master server 8, which returns the health score immediately. In another embodiment, the captured data is automatically calibrated on the smartphone 5 or the intermediate server 7 and transferred to the master server 8 to calculate the health score.

[0053] In the embodiment shown in figure 2, each intermediate server 7 is managed by a respective doctor, who can therefore monitor the progress of each of his patients. The intermediate servers 7 communicate with a master server 8, which together with each intermediate server 7 constitutes a data exchange platform for the health scores calculated by the calculation unit 4, and for storing each overall health score in the intermediate server 7, and for transmitting the scores to storage and display means associated with specific input means for the patient, typically a smartphone 5.

[0054] The unit 4 for calculating a numerical score representative of the patient's overall health is arranged to calculate a patient's health score instantaneously each time values ​​of health indicators influencing the health score are entered manually or automatically into the data input means 2A, 2B, 2C. In this way, the overall health score of each patient stored in the data exchange platform on the one hand and in the storage and display means associated to the specific input means for the patient on the other hand is automatically updated.

[0055] For example, for each sports activity, as shown in Fig. 1, the patient's smartphone 5 connected to a connected watch 9 and a heart rate belt 10 records data influencing the health score and transmits it to the intermediate server 7, which in turn transmits it to the master server 8. In this way, the patient's health score is automatically updated by the calculation unit 4 located in the master server 8.

[0056] The calculation unit 4 in the master server 8 may include a computer module programmed to calculate a numerical score representative of the patient's overall health according to a weighting of the patient's health index values, for example according to the algorithm described in WO201611734.

[0057] Similarly, when the doctor enters values ​​that affect the patient's health score into the keyboard 2B of the intermediate server 7, the calculation unit 4 of the master server 8 immediately recalculates the patient's health score, particularly in accordance with the actual blood test results, and the patient can immediately view the new health score on, for example, his or her smartphone 5.

[0058] The phone app allows patients to access their health scores and track their progress over time by day, week or month.

[0059] The measurements of the indicators are used to establish a score for each of the indicators based on the measurements relative to a baseline value.

[0060] To carry out the method described in WO2016110734, values ​​corresponding to each of the four groups constituted by indicators are entered into the input means 2A, 2B, 2C, each group representing information respectively corresponding to the patient's physical capabilities combined with information about the general health state, hereinafter group 1: oxidative stress, hereinafter group 2: gastrointestinal system function, hereinafter group 3: nervous system function, hereinafter group 4.

[0061] Finally, the computation unit 4 located within the master server 8 uses a computer algorithm to calculate a patient specific health score S on a scale from 0 to 100 using the following formula: S = Σ(group 1 value + (2 * Group 2 Value)+(2 * Group 3 values)+(3 * Group 4 Value) / (2 * number of groups).

[0062] For example, a patient with a Group 1 value of 49.17, a Group 2 value of 47.27, a Group 3 value of 86.92, and a Group 4 value of 99.12 would have a health score S=76.86.

[0063] In this example, the closer the health score value is to 100, the healthier the patient is.

[0064] Figure 2 shows a system for processing the health-related indicator values ​​of five patients to determine a numerical score representative of the overall health of each patient. Referring also to figure 1, the system comprises a database 1 in the master server 8 and also in the intermediate server 7. This database stores a set of health indicator values ​​calibrated according to standardized values. Each intermediate server 7 is associated with each patient's smartphone 5 and constitutes a means for inputting a set of health indicator data of each patient among the standardized values. The system further comprises a storage unit 3B in the intermediate server 7 and a storage unit 3A in the master server 8 for storing the data received by the input means 2A, 2B, 2C, and a calculation unit 4 in the master server 8 for calculating a numerical score representative of the overall health according to a weighting of the health indicator values.

[0065] In this embodiment, the input means comprises one smartphone 5 for each patient, i.e. five smartphones 5 each equipped with a sensor 6 arranged to receive raw health indicator data from each patient and to calibrate this raw data according to standardized values ​​from a database (either in the smartphone 5 or in the intermediate server 7).

[0066] Storage units are integrated in each smartphone 5, in each of the two intermediate servers 7 and in the master server 8, and the two intermediate servers 7 and the master server 8 receive data calibrated to standardized values ​​from a database via communication means.

[0067] In this example, the first intermediate server 7 tracks two patients and the second intermediate server 7 tracks three patients. In this way, each doctor can monitor the progress of each of his patients. Each intermediate server 7 communicates with the master server 8 and constitutes a data exchange platform for the health scores calculated by the calculation unit 4 and for storing the overall health score of each patient in a location associated to an input means specific to the patient, i.e. the smartphone 5.

[0068] The unit 4 for calculating a numerical score representative of the patient's overall health is arranged to calculate the patient's health score instantly each time data of health indicator values ​​influencing the health score are integrated manually or automatically, so that the overall health score of each patient stored in the smartphone 5 constituting a data exchange platform and a storage / display device associated to the patient-specific input means is automatically updated by the master server 8.

[0069] For example, after each sports activity, the smartphone 5 of each patient records the data that influences the health score and transmits it to the storage units 3A, 3B, which in turn transmit it to the master server 8. In this way, the health score of the patient is automatically updated by the master server 8.

[0070] Similarly, when each of the two doctors enters values ​​that affect the health score at keyboard 2B of intermediate server 7, each patient can instantly see the new health score, especially in relation to the actual state of the blood test results.

[0071] For example, a four month period is sufficient to demonstrate significant changes that have a real impact on health. It is only at the end of this period that improvements become visible in the patient's blood balance and sleep quality, which are the best indicators of reptilian brain function. Comparative analysis of pre- and post-program ratings demonstrates an improvement in the patient's health scores.

Claims

1. 1. A system for processing health index values ​​to determine, for each individual patient of a plurality of patients, a numerical score representative of the patient's overall health, comprising: a database (1) containing a series of indicator values ​​for different aspects of health, calibrated using standardized values, and means (2A, 2B, 2C) for inputting a series of health indicator data of a patient, said data being among said standardized values; a storage unit (3A, 3B) for the data received by said input means (2A, 2B, 2C), a unit (4) for calculating a numerical score representative of the overall health of said patient according to a weighting of the patient's health indicator data values, The system comprises: a plurality of input means (2A, 2B, 2C), each associated with at least one patient; a plurality of intermediate servers (7), each intermediate server (7) associated with said input means (2A, 2B, 2C) of one or more patients; a master server (8) for all intermediate servers (7), said master server (8) comprising a computing unit (4); an electronic sensor device (5) comprising at least one sensor (6) associated with the input means (2A, 2B, 2C) for receiving raw data indicators of different aspects of the patient's health from said input means (2A, 2B, 2C); calibration means integrated in said input means (2A, 2B, 2C), intermediate server (7) or master server (8) for calibrating the raw data from the sensors (6) according to calibrated values ​​and the standardized values ​​from the database (1) and for transferring said calibrated values ​​to said storage unit (3A, 3B) arranged to transmit said calibrated data to the calculation unit (4) of the master server (8), each intermediate server (7) constitutes together with said master server (8) a data exchange platform for the health scores calculated by said calculation unit (4) of said master server (8), said data exchange platform being arranged to store the overall health score of each patient on a display device (5) associated to said input means specific to said patient, The system is characterized in that the calculation unit (4) of the master server (8) is arranged to calculate a patient's health score instantaneously each time the input means (2A, 2B, 2C) integrates patient health indicator data whose value affects the calculation of the health score, thereby automatically updating the overall health score of each patient stored in the display device (5) associated to the input means that is specific to the patient.

2. 2. The system according to claim 1, wherein at least one of said input means (2A, 2B, 2C) comprises a keyboard for manual data entry as well as an input for computer processed data.

3. 3. The system according to claim 1 or 2, comprising a database (1) in the master server (8) or in each intermediate server (7).

4. The system according to any one of claims 1 to 3, wherein each of said input means (2A, 2B, 2C) comprises a device (5) for storing and displaying the overall health score of each patient.

5. The system according to any one of claims 1 to 4, wherein the calculation unit (4) is arranged to calculate the health score according to at least three, preferably at least four parameters representing different health index values.

6. 6. The system according to claim 5, wherein the calculation unit (4) is configured to calculate the health score according to weighted values ​​of four parameter groups representing different values ​​of health indices corresponding respectively to oxidative stress index, digestive brain function, reptilian brain function and general health status of the patient.

7. The system according to claim 5 or 6, wherein the calculation unit is configured to calculate the health score by taking into account values ​​of cardiac amplitude, perception time and Omega-3 index.

8. The system according to any one of the preceding claims, wherein the electronic sensor device (5) of the input means is a smartphone, a connected watch (9) or a heart rate belt (10).

9. A system according to any one of claims 1 to 8, wherein the assembly of each intermediate server (7) with its respective input means (2A, 2B, 2C) and said electronic sensor devices (5) are grouped in a single device or integrated in several devices grouped in the same location.

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