Method for producing alpha-cyclodextrin
JP2025519570A5Pending Publication Date: 2026-06-16ベレン セラピューティクス ピービーシー
Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- ベレン セラピューティクス ピービーシー
- Filing Date
- 2023-06-09
- Publication Date
- 2026-06-16
AI Technical Summary
Technical Problem
Current cyclodextrin production methods face challenges such as supply chain deficiencies, scalability issues, quality variability, high purification costs, and the need for FDA approval of starch after each growth stage.
Method used
A method for biosynthetically producing cyclodextrin from sucrose without using starch as a starting material, involving the enzymatic conversion of sucrose to amylose and then to cyclodextrin using variant enzymes to enhance yield and purity.
Benefits of technology
This method increases the overall yield of cyclodextrin, improves its purity, reduces by-product waste, and allows for the production of alpha-cyclodextrin in higher amounts and concentrations compared to beta-cyclodextrin and gamma-cyclodextrin.
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Abstract
This specification provides a method for the enzymatic production of alpha-cyclodextrin from sucrose. Optionally, the method involves contacting sucrose with one or more enzymes to convert sucrose to amylose, and subsequently contacting amylose with one or more enzymes to convert amylose to alpha-cyclodextrin. Optionally, the method produces alpha-cyclodextrin in a higher yield compared to beta-cyclodextrin, gamma-cyclodextrin, or both.
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