Methods for Providing High SPF to Topical Body Surfaces

Abstract

The present invention relates to a method for providing a high Sun Protection Factor (SPF) and UVA Protection Factor (UVAPF) to topical surfaces of the human body. The method provides a synergistic benefit of SPF and UVAPF that exceeds that which can be achieved through two separate, sequential steps: cleansing followed by application of a leave-on composition to the same skin surface. The method involves cleansing the skin with a foam composition containing a water-soluble sunscreen, generated from a container equipped with a pump, followed by application of a leave-on composition that may include an optional sunscreen.

Description

[Technical Field]

[0001] The present invention relates to a method for providing a high Sun Protection Factor (SPF) to topical surfaces of the body, preferably the human body, and more preferably provides a synergistic benefit of SPF that exceeds that which can be achieved through two separate, sequential steps: cleansing the skin with a particular cleansing foam composition delivered from a container having a pump, followed by applying a sunscreen composition to the same skin surface. [Background technology]

[0002] Solar radiation contains approximately 5% ultraviolet (UV) radiation, with wavelengths ranging from 200 nm to 400 nm. It is further classified into three wavelength ranges: 320 nm to 400 nm (UV-A), 290 nm to 320 nm (UV-B), and 200 nm to 290 nm (UV-C). Short-term exposure to UV-A and UV-B radiation is known to cause skin redness and local irritation. Continuous and prolonged exposure can result in sunburn, melanoma, and wrinkle formation. UV rays have also been reported to cause significant damage to hair. Therefore, people want to protect their skin and hair from the harmful effects of both UV-A and UV-B radiation.

[0003] Various cosmetic products, such as creams, lotions, or gels, that can be applied to the skin have been reported to prevent and / or protect the skin from the harmful effects of ultraviolet rays. These cosmetic compositions typically contain various types of organic sunscreens, particularly those capable of absorbing UV-A and / or UV-B radiation present in sunlight. Therefore, both UV-A and UV-B sunscreens are typically incorporated into photoprotective compositions to provide protection against the full range of ultraviolet rays. Such leave-on compositions are applied to the skin before a person goes outdoors and remain on the skin until the person next washes.

[0004] Another method of applying sunscreen to skin is by wash-off products, such as soap, face wash or body wash products, where sunscreen is incorporated into skin cleansing products and delivered to skin simultaneously with the cleaning process.However, the main purpose of wash-off products is to remove dirt and oil from skin surface, and the active substance in wash-off products is likely to be washed off at the same time, so delivering sunscreen to skin is a very difficult task.Therefore, it is an ongoing challenge to improve the adhesion of active substance through wash-off products.

[0005] The inventors, with years of experience in understanding the properties of available sunscreens and knowledge of the surface science of surfactant systems, have, through extensive experimentation, found a solution to the problem of providing a high SPF to the skin. The inventors discovered a unique two-step method that synergistically improves SPF compared to each step individually. The method involves cleansing the skin with a foam composition containing a water-soluble sunscreen, generated from a container equipped with a foam-generating pump, followed by applying a leave-on sunscreen composition to the skin.

[0006] EP 1261688 (Unilever, 2001) discloses personal cleansing compositions that deposit high levels of sunscreen (SPF>2) while maintaining good lather (i.e., minimal lather degradation over time compared to compositions containing more "oily" sunscreens). Enhanced deposition is seen in both bar and liquid compositions and is based on the solubility or insolubility of the sunscreen used.

[0007] The inventors have found that while either wash-off or leave-on sunscreen compositions have limitations in the SPF they can achieve, the latter are more effective. Incorporating greater amounts of sunscreen, as taught in the prior art, generally does not consistently increase deposition efficacy and the SPF achieved thereby. [Prior art documents] [Patent documents]

[0008] [Patent Document 1] European Patent No. 1261688 Summary of the Invention [Problem to be solved by the invention]

[0009] It is therefore an object of the present invention to provide a method that obviates at least some of the drawbacks of the prior art and provides an enhanced, even synergistic, SPF compared to known techniques.

[0010] Another object of the present invention is to provide a method that results in an SPF greater than 10 and a UVAPF (UV-A Protection Factor) greater than 4. [Means for solving the problem]

[0011] According to a first aspect of the present invention, there is provided a method of providing a high SPF to a topical body surface, comprising the steps of: (a) cleaning the surface with a wash-off composition produced as a foam from a container equipped with a pump, the wash-off composition comprising: (i) 0.1 to 10 wt. % of a water-soluble UVA sunscreen; (ii) 0.1 to 10 wt. % of a water-soluble UVB sunscreen; (iii) 3 to 80 wt. %, preferably 6 to 80 wt. %, of a mild surfactant selected from one or more of anionic, zwitterionic, and nonionic surfactants; (iv) a cosmetically acceptable carrier; and preferably diluted with water, followed by a washing step (b) rinsing the surface with water, followed by (c) applying a leave-on composition to said surface comprising a sunscreen and a cosmetically acceptable vehicle; A method is provided, comprising:

[0012] A second aspect of the present invention provides a wash-off composition comprising: (a) a hand-held container equipped with a pump capable of generating foam, the wash-off composition comprising 0.1 to 10% by weight of a water-soluble UVA sunscreen, 0.1 to 10% by weight of a water-soluble UVB sunscreen, 3 to 80% by weight, preferably 6 to 80% by weight of a mild surfactant selected from one or more of anionic, zwitterionic, or nonionic surfactants, and a cosmetically acceptable carrier; (b) a leave-on composition comprising a sunscreen and a cosmetically acceptable vehicle; (c) Instructions for use and The present invention relates to a kit comprising: DETAILED DESCRIPTION OF THE INVENTION

[0013] These and other aspects, features, and advantages will become apparent to those skilled in the art upon reading the following detailed description and the appended claims. For the avoidance of doubt, any feature of one aspect of the present invention may be utilized in any other aspect of the present invention. The term "comprising" is intended to mean "including," but does not necessarily mean "consisting of" or "composed of." In other words, the listed steps or options need not be exhaustive. It should be noted that the examples given in the following description are intended to clarify the invention but are not intended to limit the invention to those examples themselves. Similarly, unless otherwise indicated, all percentages are weight / weight percentages. Except in the examples and comparative examples, or where otherwise expressly stated, all numbers in the specification and claims expressing amounts of materials or reaction conditions, physical properties and / or uses of materials should be understood to be modified by the word "about." Numerical ranges expressed in the format "from x to y" are understood to include x and y. When multiple preferred ranges for a particular feature are listed in the format "x to y," it is understood that all ranges combining the different endpoints are also contemplated.

[0014] The disclosure of the present invention found herein should be considered to cover all embodiments found in the claims as multiple dependent on each other, notwithstanding the fact that the claims may be viewed as lacking multiple dependencies or as non-repetitive. Where features are disclosed with respect to a particular aspect of the invention (e.g., a method of the present invention), such disclosure should be considered to apply mutatis mutandis to any other aspect of the invention (e.g., a kit of the present invention). Preferably, the method or use is non-therapeutic or cosmetic in nature.

[0015] As used herein, the term "wash-off composition" refers to a composition for cleansing topical surfaces of mammals, particularly humans. This composition is particularly useful for use on sun-exposed areas of the body. Such compositions are generally rinse-off, meaning that the composition contains a high content of surfactants known to aid in cleaning surfaces and freeing them from oil and dirt. Wash-off compositions are generally used by diluting them with water when applied to the skin, scalp, or hair. The consumer then lathers the composition to ensure that the dirt and oil on the surface are solubilized in the micelles of the surfactant solution, and then rinses the body with plenty of water to ensure that the surface is substantially free of the composition. The wash-off composition of the present invention is contained in a container equipped with a pump. When the pump on the container is activated, the composition is released from the container as a foam, which is then used by the consumer to clean the desired surface of the body. As used herein, "skin" refers to the face and body (e.g., neck, chest, back, arms, armpits, hands, legs, buttocks, and scalp), especially the skin on the sun-exposed areas thereof. The wash-off compositions of the present invention also relate to application to any other keratinous substrate of the human body other than skin, such as the scalp and hair, where products can be formulated specifically to provide photoprotection. It has been observed that use of the wash-off compositions of the present invention substantially removes dirt and oil from the skin surface during the washing and rinsing process. Furthermore, surprisingly, the specific combination of incorporated sunscreens ensures deposition of much greater amounts than would typically be expected from a rinse-off product, such that the deposited sunscreen interacts synergistically with sunscreens subsequently applied from a leave-on composition to enhance the SPF and UVA / UVA benefits. Enhanced deposition results in a high Sun Protection Factor (SPF). A high SPF according to the present invention preferably refers to a composition having an SPF of at least 10, more preferably at least 15, more preferably greater than 20, even more preferably greater than 30, even more preferably greater than 50, often greater than 80, and optimally greater than 100. Most preferably, the present invention provides an SPF in the range of 20-50. The SPF can be as high as 160.The SPF in the present invention is measured using a transmittance measurement technique. The method of the present invention also provides a high UVAPF. By high UVAPF, we mean that the method provides a UVAPF of at least 4, preferably greater than 8, more preferably greater than 12, even more preferably greater than 16, and most preferably greater than 20. (初期) In particularly preferred embodiments, the present invention provides UVAPF values ​​ranging from 4 to 16. The UVAPF can be as high as 40.

[0016] The wash-off composition used in the first step of the method of the present invention comprises 0.1 to 10% by weight of a water-soluble UVA sunscreen, 0.1 to 10% by weight of a water-soluble UVB sunscreen, 3 to 80% by weight, preferably 6 to 80% by weight, of a mild surfactant selected from one or more of anionic, zwitterionic and nonionic surfactants, and a cosmetically acceptable carrier.

[0017] Water-soluble sunscreen means that the solubility of the sunscreen in water at 25°C, whether UVA or UVB, is greater than 10 g / L, preferably greater than 50 g / L. The wash-off composition is contained in a container. The container may preferably be handheld. The container has a pump at its top, and when the pump is activated by pressing down with a finger or thumb, the composition mixes with air and is expelled from the container as foam. Various ways in which a pump-equipped container can be realized are described below.

[0018] The container contains a sprayable foamable composition. The container may be realized using a spray device containing the foamable composition. The spray device may include a bottle with a nozzle and a spray pump dispenser. Thus, the present invention provides a cleaning system including the spray device. The spray device includes a container holding the foamable wash-off composition, a spray head, and a liquid supply device for transferring the foamable wash-off composition from the container to the spray head to form a foam. The generated foam generally has a density of less than 0.4 g / ml when released from the spray device through the spray head.

[0019] The spray device used in the present invention comprises a container having an internal volume preferably of 25 to 1000 ml, more preferably 50 to 800 ml, even more preferably 60 to 750 ml, and most preferably 75 to 500 ml. The spray device preferably comprises a positive displacement pump that acts directly on the foaming wash-off composition. The pump draws the composition into a liquid supply device, transfers the composition to a spray head, and dispenses it from the spray head, preferably through a nozzle, in the form of a foam.

[0020] In the spray device, dispensing of the wash-off composition is preferably powered by user effort; i.e., the liquid cleaning composition is not dispensed under pressure by simply actuating a valve, but requires a manual trigger. The spray device used in accordance with the present invention is preferably selected from a trigger-spray foam bottle, a squeeze foam bottle, and a foam pump. Most preferably, the spray device is a squeeze foam bottle or a foam pump. In another preferred embodiment, the spray device is configured to mix the liquid cleaning composition with air before dispensing from the spray head. The composition can be placed in a reservoir of a plastic squeeze bottle containing a foam spray head or other foam-generating means. Upon squeezing the container, the wash-off composition leaves the reservoir and enters an air mixing chamber or foam chamber via an internal dip tube. The foam generated in the foam chamber often passes through a homogenizing element interposed between the air mixing chamber and the discharge opening to homogenize and control the density of the dispensed foam. Further compression of the foam causes it to be dispensed from the discharge cap as a uniform, unpressurized, aerated foam. Alternatively, the container may have a rigid sidewall and a dip tube fitted with a pump that is activated by a push button, which draws the composition into an air mixing or foaming chamber to produce the desired foam.

[0021] A preferred UVB sunscreen for use in the wash-off composition is phenylbenzimidazole sulfonic acid (PBSA) or benzylidene camphor sulfonic acid, preferably PBSA.

[0022] PBSA has the following chemical structure: [ka] 2-Phenylbenzimidazole 5-sulfonic acid PBSA, also known as Ensulizole, is commercially available as Eusolex 232 (Merck KGaA). PBSA is also available under the trade names Neo Heliopan Hydro (Symrise), Parsol HS (DSM), and Sunsafe ES (Uniproma). It is generally used in a water-solubilized form after neutralization to provide the desired benefits.

[0023] Benzylidene camphor sulfonic acid has the following chemical structure: Benzylidene camphor sulfonic acid is generally used in a water-solubilized form before / after neutralization to provide the desired benefits. [ka] Preferred UVA sunscreens for use in the wash-off composition are one or more of phenyldibenzimidazole tetrasulfonate disodium (Neoheliopan AP) or terephthalidene dicamphorsulfonic acid (TDSA).

[0024] Disodium phenyldibenzimidazole tetrasulfonate, also known as bisdisulizole disodium, has the chemical structure shown below. [ka] It is commercially available as Neo heliopan AP (manufactured by Symrise Shanghai Ltd) or Sunsafe DPDT (manufactured by Uniproma). It is generally used in a water-solubilized form after neutralization to provide the desired benefits.

[0025] Terephthalidenedicamphorsulfonic acid (TDSA) has the following structure: [ka] It is also known as Ecamsule. It is commercially available as Mexoryl SX (US4585597) by L'Oreal or Sunsafe TDSA (Uniproma). It can be used as the parent acid or its salt in a water-solubilized form to provide the desired benefits.

[0026] The wash-off composition preferably contains 0.1 to 10% by weight, more preferably 0.25 to 8% by weight, and even more preferably 0.5 to 5% by weight, of a water-soluble UVA sunscreen. The composition preferably contains 0.1 to 10% by weight, more preferably 0.25 to 8% by weight, and even more preferably 0.5 to 5% by weight, of a water-soluble UVB sunscreen. Certain sunscreens exist that have both UVA and UVB screening efficacy. One such sunscreen provides both UVA and UVB protection, such as benzophenone-4. Benzophenone-4 (Sulisobenzone) has the following chemical structure: [ka] Such sunscreens may also be included in the wash-off composition of the present invention. When included, it should be interpreted as including one type of sunscreen, namely, either a UVA sunscreen or a UVB sunscreen, but not both. Therefore, when included as a UVA sunscreen, it is essential to include another sunscreen as a UVB sunscreen. Similarly, when included as a UVB sunscreen, it is essential to include another sunscreen as a UVA sunscreen.

[0027] Water-soluble sunscreens for inclusion in the wash-off compositions of the present invention are generally commercially available in their acid form. When included in the acid form (pre- / partially neutralized form), i.e., compositions containing sulfonic acid groups (—SO₃H), the wash-off compositions further contain a neutralizing agent to convert the acid form to a salt form, which is known to be active as a sunscreen, except for Mexoryl SX, which can function as a sunscreen with or without neutralization. When included, the neutralizing agent is preferably present in an amount of 0.05% to 4% by weight of the composition. The neutralizing agent is preferably an inorganic or organic alkali. The organic alkali is preferably an amine, such as triethanolamine or diethanolamine. The inventors have observed that inorganic alkalis are particularly preferred. Alkali metal hydroxides are preferred. The most preferred metal hydroxides for inclusion as a neutralizing agent in the compositions of the present invention are sodium hydroxide or potassium hydroxide.

[0028] One of the objectives of the first step of the method of the present invention is to ensure that as much sunscreen as possible is deposited on the skin throughout the wash-off process. Without wishing to be bound by theory, the inventors believe that this is achieved by a selected combination of sunscreens, selected for their structure and solubility, in a selected foaming surfactant composition that determines their separation between the rinse water and the cleaned surface, resulting in high sunscreen deposition.

[0029] The wash-off compositions of the present invention contain a mild surfactant delivered in the form of a foam to aid in cleansing. To enable cleansing, the mild surfactant comprises 3-80% by weight of the composition, preferably 6-80% by weight, and even more preferably 10-75% by weight. By mild, we mean a zein number less than 100 or a zein dissolved weight percent value less than 6%. Zein dissolved weight percent is defined in U.S. Pat. No. 9,655,866, entitled "Mild antibacterial cleansing compositions."

[0030] The mild surfactant is preferably an anionic surfactant selected from one or more of isethionate, glycinate, cocoate, olefin sulfonate, sulfoacetate, and sulfosuccinate surfactants. Preferred mild anionic surfactants are selected from one or more of cocoyl isethionate, potassium cocoyl glycinate, and potassium cocoate, alpha olefin sulfonate (AOS), sodium lauryl sulfoacetate, alkyl ether sulfoacetate, sodium dioctyl sulfosuccinate, and alkyl ether sulfosuccinate. These anionic surfactants are preferably present at a level of 1 to 50%, preferably 2 to 35%, and even more preferably 10 to 35% by weight of the wash-off composition.

[0031] The wash-off compositions of the present invention preferably comprise a mild amphoteric surfactant which may be selected from one or more of cocoamidopropyl hydroxysultaine, cocoamidopropyl betaine, sodium lauroamphoacetate and sodium cocoamphoacetate.

[0032] When included, the wash-off composition comprises 0.1 to 10 wt. %, preferably 0.5 to 8 wt. %, more preferably 1 to 5 wt. % of a mild amphoteric surfactant.

[0033] The wash-off compositions of the present invention preferably comprise a mild non-ionic surfactant which may be selected from one or more of polysorbate 20, polysorbate 60, sorbitan laurate, decyl glucoside and lauryl glucoside.

[0034] If included, the wash-off composition comprises greater than 0.5 to less than 30% by weight, preferably 1 to 20% by weight, of a mild non-ionic surfactant.

[0035] The wash-off compositions of the present invention comprise a cosmetically acceptable carrier. The cosmetically acceptable carrier is preferably an aqueous solution / dispersion of a cosmetically acceptable adjuvant. The wash-off compositions of the present invention generally contain water. Wash-off compositions are generally formulated in liquid, emulsion, or gel form, with the water content generally ranging from 50 to 95% by weight of the composition, preferably from 60 to 85% by weight.

[0036] Further adjuvants that may be used to constitute a cosmetically acceptable carrier for the wash-off composition are described below.

[0037] The wash-off composition preferably contains a polyhydric alcohol (also called a polyol) or a mixture of polyols. Polyol is a term used herein to refer to compounds with multiple hydroxyl groups (at least two, preferably at least three) that are highly water-soluble. Many types of polyols are available, including relatively low molecular weight, short-chain polyhydroxy compounds such as glycerol and propylene glycol; sugars such as sorbitol, mannitol, sucrose, and glucose; modified carbohydrates such as hydrolyzed starch, dextrin, and maltodextrin; and polymeric synthetic polyols such as polyalkylene glycols, e.g., polyoxyethylene glycol (PEG) and polyoxypropylene glycol (PPG). Particularly preferred polyols are glycerol, sorbitol, and mixtures thereof. The most preferred polyol is glycerol. In a preferred embodiment, the bar of the present invention contains 0 to 8% by weight of polyol, preferably 1 to 7.5% by weight. Preferred wash-off compositions may further comprise up to 30% by weight of a benefit agent. Preferred benefit agents include moisturizers, emollients and anti-aging compounds.

[0038] Other optional ingredients such as antioxidants, fragrances, polymers, chelating agents, colorants, deodorants, dyes, enzymes, foam boosters, disinfectants, antibacterial agents, foaming agents, pearlescent agents, skin conditioning agents, stabilizers, or superfatting agents may be added in suitable amounts in the process of the present invention. Preferably, the ingredients are added after the saponification step. Preferably, sodium metabisulfite, ethylenediaminetetraacetic acid (EDTA), borax, or ethylenehydroxydiphosphonic acid (EHDP) are added to the formulation.

[0039] The present invention includes a second step of the method, which comprises applying a leave-on composition comprising a sunscreen and a cosmetically acceptable vehicle to a desired topical surface, such as the skin. A leave-on composition refers to a composition that is applied to a desired topical surface and remains on the surface, usually for several hours or a day, until the surface is washed, typically when a person normally bathes or showers or performs any other personal cleansing procedure. The leave-on composition of the present invention can be in the form of a liquid, lotion, cream, spray, stick, or gel. As used herein, "skin" refers to the skin of the face and body (e.g., neck, chest, back, arms, armpits, hands, legs, buttocks, and scalp), especially those parts exposed to the sun. The leave-on composition of the present invention also relates to application to any other keratinous substrate of the human body other than the skin, such as the scalp and hair, where products can be formulated specifically to provide photoprotection.

[0040] The sunscreen in the leave-on composition is an organic UVA sunscreen, an organic UVB sunscreen, an inorganic sunscreen or a mixture thereof, preferably a combination of an organic UVB sunscreen and an organic UVA sunscreen.

[0041] Preferably, the leave-on composition contains a UVA organic sunscreen that absorbs UVA radiation and prevents it from reaching the user's surface, such as the skin. Examples of sunscreens that can be used as the UVA organic sunscreen in the composition include dibenzoylmethane compounds, bisdisulizole disodium (commercially available as Neo Heliopan® AP), diethylaminohydroxybenzoylhexylbenzoate (commercially available as Uvinul® A Plus), Ecamsule (commercially available as Mexoryl SX), dimethoxyphenyl-[1-(3,4)]-4,4-dimethyl-1,3-pentanedione, and methyl anthranilate. Preferably, the sunscreen that can be used as the UVA organic sunscreen in the leave-on composition is selected from dibenzoylmethane compounds or diethylaminohydroxybenzoylhexylbenzoate, preferably dibenzoylmethane compounds. Examples of dibenzoylmethane compound sunscreens that can be used as UVA organic sunscreens in leave-on compositions include butyl methoxydibenzoylmethane or BMDM (commercially available as Parsol® 1789 or Avobenzone), 2-methyldibenzoylmethane, 4-isopropyldibenzoylmethane, 4-tert-butyldibenzoylmethane, 2,4-dimethyldibenzoylmethane, 2,5-dimethyldibenzoylmethane, 4,4'-diisopropyl-dibenzoylmethane, 2-methyl-5-isopropyl-4'-methoxydibenzoylmethane, 2-methyl-5-tert-butyl-4'-methoxydibenzoylmethane, 2,4-dimethyl-4'-methoxydibenzoylmethane, or 2,6-dimethyl-4-tert-butyl-4'-methoxydibenzoylmethane. Most preferably, the dibenzoylmethane compound that can be used as the UVA organic sunscreen is BMDM.

[0042] Preferably, the leave-on composition comprises 0.01 to 10% by weight of one or more UVA organic sunscreens, more preferably 0.1 to 8% by weight, even more preferably 1 to 6% by weight, even more preferably 1 to 5% by weight, even more preferably 1 to 3% by weight, even more preferably 1 to 2.5% by weight.

[0043] Preferably, the leave-on composition may contain a UV-B organic sunscreen. UVB organic sunscreens absorb UVB radiation and prevent it from reaching the user's surface, such as the skin. Examples of UVB organic sunscreens that can be used in the composition include compounds of the following classes: cinnamic acid, salicylic acid, diphenylacrylic acid, benzylidene camphor, and their derivatives. Examples of such compounds include 2-ethylhexyl salicylate (commercially available as Octisalate™), 3,3,5-trimethylcyclohexyl 2-hydroxybenzoate (commercially available as Homosalate™), ethylhexyl methoxycinnamate (commercially available as NeoHelipan® AV), 2-ethylhexyl 2-cyano-3,3-diphenylacrylate (OCR, commercially available as Octocrylene™), 2-hydroxy-4-methoxybenzophenone (commercially available as Oxybenzone™), 2-ethylhexyl 4-methoxycinnamate (MCX, Parsol MCX™), 3-benzylidene camphor, benzylidene camphor sulfonic acid, DEA methoxycinnamate, cinoxate, diethylhexyl butamido triazone, digalloyl trioleate, diisopropyl methyl cinnamate, ethyl dihydroxypropyl PABA, ethylhexyl dimethoxybenzylidene dioxoimidazoline propionate, ethylhexyl dimethyl PABA, ethylhexyl triazone, ferulic acid, glyceryl ethylhexanoate dimethoxycinnamate, glyceryl PABA, isoamyl p-methoxycinnamate, isopentyl trimethoxycinnamate trisiloxane, isopropyl benzyl salicylate, isopropyl methoxycinnamate, 4-methylbenzylidene camphor, PABA, PEG-25 Suitable organic sunscreens include PABA, pentyl dimethyl PABA, phenylbenzimidazole sulfonic acid, polyacrylamidomethyl benzylidene camphor, polysilicone-15, salicylic acid, TEA salicylate, and mixtures thereof. Preferably, the UVB organic sunscreens that may be used in the leave-on compositions are selected from OCR, MCX, phenylbenzimidazole sulfonic acid, ethylhexyl salicylate, and mixtures thereof.

[0044] When incorporated into the composition, UVB organic sunscreens may preferably be incorporated into the leave-on composition at 0.1 to 10 wt %, more preferably 0.5 to 7 wt %, even more preferably 1 to 5 wt %, even more preferably 1 to 3.5 wt %, even more preferably 1 to 3 wt %, and even more preferably 1 to 2.5 wt %.

[0045] Preferably, the leave-on composition may contain a UVB / A sunscreen, which is a sunscreen that absorbs both UVB and UVA radiation and prevents them from reaching the surface to which it is applied. Examples of UVB / A sunscreens that may be used in the composition include benzophenone derivatives. Examples of such compounds are benzophenone-1, benzophenone-2, benzophenone-3, benzophenone-4, benzophenone-5, benzophenone-6, benzophenone-8, benzophenone-9, beta-2-glucopyranoxypropyl hydroxybenzophenone, bis-ethylhexyloxyphenol methoxyphenyl triazine (Tinosorb S), drometrizole, drometrizole trisiloxane, and methylene bis-benzotriazolyl tetramethylbutylphenol (Tinosorb M).

[0046] Preferably, the leave-on composition comprises 0.01 to 10 wt. % of one or more UVB / A organic sunscreens, more preferably 0.1 to 8 wt. %, even more preferably 1 to 6 wt. %, even more preferably 1 to 5 wt. %, even more preferably 1 to 3 wt. %, even more preferably 1 to 2.5 wt. %.

[0047] Preferably, the composition may contain an inorganic sunscreen agent.Examples of inorganic sunscreen agents that can be used in the composition include zinc oxide (ZnO), iron oxide, silica such as fumed silica, and titanium dioxide (TiO2).Preferably, the inorganic sunscreen agents that can be used in the composition are selected from TiO2, ZnO, and mixtures thereof.

[0048] When incorporated into the composition, inorganic sunscreens may preferably be incorporated into the composition at 0.1 to 25% by weight, more preferably 0.5 to 20% by weight, even more preferably 1 to 15% by weight, even more preferably 1 to 10% by weight, even more preferably 1 to 5% by weight, and even more preferably 1 to 3% by weight.

[0049] The leave-on compositions may include one or more agents for providing radiance to the skin, such as niacinamide, picolinamide, 4-alkyl-substituted resorcinols, vitamin B6, vitamin C, vitamin A, glutathione precursors, gallazine, adapalene, aloe extract, ammonium lactate, arbutin, azelaic acid, butylhydroxyanisole, butylhydroxytoluene, citric acid esters, deoxyarbutin, 1,3-diphenylpropane derivatives, 2,5-dihydroxybenzoic acid and its derivatives, 2-(4-acetoxyphenyl)-1,3-dithiane, 2-(4-hydroxyphenyl)-1,3-dithiane, ellagic acid, glucopyranosyl-1-ascorbic acid, gluconic acid, glycosaminoglycans, glycerin, glycerol, hydroxybenzoic acid ... The following may be used as the active ingredient: lactic acid, green tea extract, 4-hydroxy-5-methyl-3[2H]-furanone, 4-hydroxyanisole and its derivatives, 4-hydroxybenzoic acid derivatives, hydroxycaprylic acid, inositol-ascorbic acid, lactic acid, lemon extract, linoleic acid, magnesium ascorbyl phosphate, 5-octanoylsalicylic acid, salicylic acid, 3,4,5-trihydroxybenzyl derivatives, acetylglucosamine, Pitera extract, SimWhite, calcium pantothenate (Melanoblock), SepiWhite, soybean extract (Bowman-Birk inhibitor), 12-hydroxystearic acid, and mixtures thereof. When used in the composition, 12-hydroxystearic acid is used as a skin brightening agent, not as a fatty acid.

[0050] Preferably, the skin brightening agent is selected from the group consisting of niacinamide, picolinamide, isonicotinamide, 12-hydroxystearic acid, 4-alkyl-substituted resorcinols, and mixtures thereof. Preferably, the skin brightening agent used in the leave-on composition is niacinamide. More preferably, the selected skin brightening agent is a 4-alkyl-substituted resorcinol selected from the group consisting of 4-ethylresorcinol (4-ER), 4-isopropylresorcinol (4-IPR), 4-butylresorcinol (4-BR), 4-pentylresorcinol (4-PR), 4-phenylethylresorcinol (4-PER), 4-HR, and mixtures thereof. Even more preferably, the selected agent is selected from the group consisting of 4-ER, 4-HR, and mixtures thereof. Even more preferably, the selected agent is 4-HR.

[0051] Preferably, the leave-on composition comprises 0.001 to 10% by weight, more preferably 0.01 to 8% by weight, even more preferably 0.1 to 7% by weight, even more preferably 0.1 to 5% by weight, even more preferably 0.1 to 3% by weight, even more preferably 0.1 to 1% by weight, even more preferably 0.25 to 0.5% by weight of skin brightening agent.

[0052] The leave-on composition comprises a cosmetically acceptable vehicle. The cosmetically acceptable vehicle is preferably in the form of an oil, liquid, stick, cream, lotion, spray or gel. The cosmetically acceptable vehicle preferably comprises ingredients such as surfactants, e.g., nonionic surfactants, fatty acids, soap, water, polymers, emollients, solvents, powders, preservatives, or optional ingredients. Details regarding various possible ingredients for inclusion in the cosmetically acceptable vehicle are provided below.

[0053] Preferably, the leave-on composition comprises a non-ionic surfactant, more preferably selected from those having an HLB value in the range of 9 to 20, preferably 10 to 19, more preferably 12 to 18, even more preferably 13 to 17, and even more preferably 15 to 17.

[0054] HLB is calculated using the Griffin method, where HLB = 20 × Mh / M, where Mh is the molecular mass of the hydrophilic portion of the molecule and M is the molecular mass of the entire molecule, giving results on an arbitrary scale from 0 to 20. Typical values ​​for various surfactants are shown below.

[0055] Value <10: Fat-soluble (water-insoluble) Value > 10: Water soluble Values ​​of 4 to 8 indicate antifoaming agents Values ​​of 7 to 11 indicate W / O (water-in-oil) emulsifiers Values ​​of 12 to 16 indicate oil-in-water emulsifiers Values ​​of 11 to 14 indicate wetting agents Values ​​of 12 to 15 are typical for detergents A value of 16-20 indicates a solubilizer or hydrotrope.

[0056] Preferably, the nonionic surfactant, having an HLB value in the range of 9 to 20, is selected from fatty alcohol ethoxylates, alkylphenol ethoxylates, polyoxyethylene sorbitan alkyl esters, and mixtures thereof. Preferably, the nonionic surfactant has at least 9 alkylene oxide groups, preferably at least 9 ethylene oxide groups.

[0057] Examples of fatty alcohol ethoxylates that may be used as nonionic surfactants in the composition include polyoxyethylene lauryl ether (HLB=16.9, commercially available as Brij® 35), polyoxyethylene (20) cetyl ether (HLB=16, commercially available as Brij® 58), polyethylene glycol octadecyl ether (HLB=18.8, commercially available as Brij® 700), and laureth-9 (C12EO9, HLB=14.3, commercially available as Brij® L9).

[0058] Examples of alkylphenol ethoxylates that may be used as nonionic surfactants in the composition include octylphenol ethoxylate (HLB=15.5, commercially available as Triton™ X165), octylphenol ethoxylate (HLB=17.6, commercially available as Triton™ X405), and octylphenol ethoxylate (HLB=18.4, commercially available as Triton™ X705).

[0059] Examples of polyoxyethylene sorbitan alkyl esters that may be used as nonionic surfactants in the compositions include polyoxyethylene sorbitan monolaurate (HLB=13.3, commercially available as Tween® 21), polyoxyethylene sorbitan monolaurate (HLB=16.7, commercially available as Tween® 20), polyoxyethylene sorbitan monopalmitate (HLB=15.6, commercially available as Tween® 40), and polyoxyethylene sorbitan monostearate (HLB=14.9, commercially available as Tween® 60).

[0060] Even more preferably, the nonionic surfactants having an HLB value in the range of 9 to 20 that may be present in the composition are fatty alcohol ethoxylates with a saturated carbon chain having an HLB greater than 15.5.

[0061] Preferably, the leave-on composition comprises 0.5-5 wt. %, more preferably 1-4 wt. %, even more preferably 2-3 wt. % of a non-ionic surfactant with an HLB range of 9-20.

[0062] Preferably, the leave-on composition contains a fatty acid. When present in the composition together with soap, the fatty acid provides a so-called vanishing cream effect, i.e., the composition, when applied to human skin, disappears on the skin without leaving noticeable streaks of the composition. Preferably, the leave-on composition contains a fatty acid having 10 to 30 carbon atoms, more preferably 12 to 25 carbon atoms, even more preferably 14 to 20 carbon atoms, and even more preferably 16 to 18 carbon atoms. Examples of fatty acids that can be used in the composition include pelargonic acid, lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, oleic acid, linoleic acid, arachidic acid, behenic acid, erucic acid, and mixtures thereof. Preferably, the fatty acid that can be used is stearic acid or palmitic acid, or a mixture thereof. The fatty acid in the present invention is preferably histoic acid, which is a substantial mixture (generally about 90 to 95%) of stearic acid and palmitic acid in a ratio of between 55:45 and 45:55.

[0063] Preferably, the leave-on composition comprises 2.25 to 25 wt. % fatty acids, more preferably 4 to 22 wt. %, even more preferably 6 to 20 wt. %, even more preferably 8 to 19 wt. %, even more preferably 10 to 18 wt. %, even more preferably 12 to 16 wt. %.

[0064] Preferably, the leave-on composition contains soap. When present in combination with a fatty acid in the composition, the soap provides a vanishing cream effect. Preferably, the soap in the leave-on composition is generally prepared by in situ neutralization of the fatty acids that may be present in the composition. Therefore, the soap preferably has a carbon chain length corresponding to the chain length of the fatty acid in the composition. The soap is formed from the fatty acid using an alkali metal hydroxide, such as sodium hydroxide or potassium hydroxide. Of these, potassium hydroxide is more preferred. Therefore, the soap is preferably a potassium soap (fatty acid potassium salt).

[0065] Preferably, the leave-on composition comprises 0.1 to 10% by weight of soap, more preferably 0.25% to 8% by weight, even more preferably 0.5 to 7% by weight, even more preferably 0.5 to 5% by weight, even more preferably 0.5% to 3%.

[0066] Preferably, the leave-on composition comprises water in an amount of 5 to 99.9% by weight, more preferably 10 to 95% by weight, even more preferably 15 to 90% by weight, even more preferably 20 to 80% by weight, even more preferably 25 to 75% by weight, even more preferably 30 to 70% by weight.

[0067] Preferably, the leave-on composition comprises a polymer, which acts as a thickener in the composition and improves the sensory properties of the composition.

[0068] The polymer is preferably selected from the following classes:

[0069] Acrylates / R-methacrylate copolymers, such as acrylates / steareth-20 methacrylate copolymer (commercially available as Aculyn® 22) and acrylates / beheneth-25 methacrylate copolymer (commercially available as Aculyn® 28); Acrylate / R-methacrylate crosspolymers, such as acrylate / steareth-20 methacrylate crosspolymer (commercially available as Aculyn™ 88); acrylate copolymer (commercially available as Aculyn™ 33), Acrylates / R-alkyl acrylate crosspolymers, such as acrylates / C10-C30 alkyl acrylate crosspolymer (commercially available as Pemulen™ TR-2); Copolymer of ammonium acryloyldimethyltaurate and vinylpyrrolidone (commercially available as Aristoflex® AVC), Copolymer of sodium acryloyldimethyltaurate and vinylpyrrolidone (commercially available as Aristoflex® AVS), and Crosspolymers of acryloyldimethyltaurate with R-alkyl acrylates and methacrylates, such as ammonium acryloyldimethyltaurate / beheneth-25 methacrylate crosspolymer (commercially available as Aristoflex® HMB and Aristoflex® BLV).

[0070] Preferably, the leave-on composition comprises 0.1 to 5 wt. % of the polymer, more preferably 0.25 to 4.5 wt. %, even more preferably 0.5 to 4 wt. %, even more preferably 0.75 to 3.5 wt. %, even more preferably 0.75 to 2.75 wt. %.

[0071] Preferably, the leave-on composition comprises an emollient. Examples of emollients that may be used in the leave-on composition include stearyl alcohol, glyceryl monoricinoleate, mink oil, cetyl alcohol, isopropyl isostearate, isobutyl palmitate, isocetyl stearate, oleyl alcohol, isopropyl laurate, hexyl laurate, decyl oleate, octadecane-2-ol, isocetyl alcohol, eicosanyl alcohol, behenyl alcohol, cetyl palmitate, silicone oils such as dimethylpolysiloxane, di-n-butyl sebacate, isopropyl myristate, Isopropyl palmitate, isopropyl stearate, butyl stearate, polyethylene glycol, triethylene glycol, lanolin, cocoa butter, corn oil, cottonseed oil, olive oil, palm kernel oil, rapeseed oil, safflower seed oil, evening primrose oil, soybean oil, sunflower seed oil, avocado oil, sesame seed oil, coconut oil, peanut oil, castor oil, acetylated lanolin alcohol, petrolatum, mineral oil, butyl myristate, isopropyl linoleate, lauryl lactate, myristyl lactate, decyl oleate, myristyl myristate and mixtures thereof.

[0072] Preferably, the leave-on composition comprises a solvent. Examples of solvents that may be used in the composition include ethyl alcohol, isopropanol, acetone, ethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol monoethyl ether, and mixtures thereof.

[0073] Preferably, the leave-on composition comprises a powder. Examples of powders that can be used in the composition include chalk, talc, fuller's earth, kaolin, starch, gum, colloidal silica sodium polyacrylate, tetraalkyl and / or trialkylarylammonium smectite, chemically modified magnesium aluminum silicate, organically modified montmorillonite clay, hydrated aluminum silicate, fumed silica, carboxyvinyl polymer, sodium carboxymethylcellulose, ethylene glycol monostearate, and mixtures thereof.

[0074] Preferably, the leave-on composition contains a preservative to protect against the growth of potentially harmful microorganisms. Examples of ingredients that can be used as preservatives in the composition include alkyl esters of parahydroxybenzoic acid, hydantoin derivatives, propionates, and various quaternary ammonium compounds. More preferably, ingredients that can be used as preservatives in the composition are sodium benzoate, iodopropynyl butylcarbamate, methylisothiazolinone, iodopropynyl butylcarbamate, phenoxyethanol, methylparaben, propylparaben, imidazolidinyl urea, sodium dehydroacetate, ethylhexylglycerin, benzyl alcohol, alkanediols, and mixtures thereof. Suitable alkanediols for use as preservatives include C6-C alkyl esters vicinal substituted with hydroxy groups. 12 Illustrative examples include 1,2-octanediol (caprylyl glycol), 2,3-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-hexanediol, 3,4-octanediol, mixtures thereof, and the like, with caprylyl glycol typically being most preferred.

[0075] When present in a leave-on composition, the preservative is preferably added in an amount of 0.001 to 5% by weight, more preferably 0.01 to 3% by weight, most preferably 0.02 to 2% by weight, and even most preferably 0.25 to 1.5%.

[0076] Preferably, the leave-on composition contains a range of other optional ingredients including antioxidants, binders, buffers, colorants, astringents, fragrances, opacifiers, conditioners, exfoliants, pH adjusters, skin feel agents, skin soothing agents, and skin healing agents.

[0077] The present invention relates to a method as described in detail hereinabove, i.e., the step of washing a surface with a wash-off composition, followed by rinsing, followed by applying a leave-on composition. After the rinsing step, the skin is preferably dried by patting the surface with a towel to leave the surface substantially dry. The step of applying the leave-on composition after the rinsing step may occur any time between 1 minute and 1 hour after the rinsing step. Preferably, the step of applying the leave-on composition is between 1 minute and 30 minutes, more preferably between 1 minute and 10 minutes, and even more preferably between 1 minute and 5 minutes after the rinsing step. Preferably, the method is non-therapeutic or cosmetic in nature.

[0078] The present invention also relates to a method for providing topical body surfaces with SPF 10, at least 20, preferably at least 30, more preferably at least 50. Preferably, the method is non-therapeutic or cosmetic in nature. The present invention also relates to a method for providing UVA F of 4 to the skin and at least UVA F of 8, preferably at least 12, more preferably at least 16 to topical body surfaces. Preferably, the method is non-therapeutic or cosmetic in nature.

[0079] According to another aspect of the present invention, a hand-held container equipped with a pump capable of generating foam and containing a wash-off composition comprising 0.1 to 10% by weight of a water-soluble UVA sunscreen, 0.1 to 10% by weight of a water-soluble UVB sunscreen, 3 to 80% by weight, preferably 6 to 80% by weight of a mild surfactant selected from one or more of anionic, zwitterionic, or nonionic surfactants, and a cosmetically acceptable carrier; a leave-on composition comprising the sunscreen and the cosmetically acceptable vehicle; and instructions for use. Preferably, the method is non-therapeutic or cosmetic in nature.

[0080] The invention will now be demonstrated with the aid of the following non-limiting examples.

[0081] [Example] Wash-off compositions 1-2: The following skin cleansing compositions were prepared as shown in Table 1 below. [Table 1] Leave-on compositions 3-5: The following leave-on compositions were prepared as shown in Table 2 below. [Table 2] TIFF2025535160000008.tif19156The following experiment was carried out using the above sample. The procedure used for the wash-off compositions was as follows: A diluted wash-off product of Composition 1 or 2 was applied to pre-wet in-vitro skin. Immediately after product application, the in-vitro skin was rinsed and stored in the dark to dry. After the drying step, the in-vitro skin was exposed to UV light, and a transmittance scan was recorded. This scan provides transmittance as a function of wavelength (290-400 nm) for a given sample. Four different locations were scanned for a single in-vitro skin sample. The same was repeated for two in-vitro skin samples. Therefore, the reported data is the average of eight readings. A reference transmittance scan was obtained using blank in-vitro skin spread with glycerin as a control. Using the software provided with the instrument, the transmittance values ​​were used to obtain SPF and UVAPF values.

[0082] The procedure used for the leave-on compositions is as follows: 2 mg / cm of the leave-on product (Composition 3 or 4 or 5) was applied to in vitro skin after washing with Composition 1 or 2. 2The in vitro skin was then applied to the same side of cleansed in vitro skin to mimic a consumer scenario. The applied in vitro skin was then allowed to dry in the dark for 20-30 minutes, replicating the recommended drying time from the in vivo ISO 24444 method. After drying, the in vitro skin was exposed to UV light, and a transmittance scan was recorded. This scan provides transmittance as a function of wavelength (290-400 nm) for a given sample. Four different locations were scanned for a single in vitro skin sample. This was repeated for two in vitro skin samples. Therefore, the reported data are the average of eight readings. A reference transmittance scan was obtained using a blank in vitro skin spread with glycerin as a control. The transmittance values ​​were used to obtain SPF and UVAPF values ​​using the software provided with the instrument.

[0083] Example 1: SPF and UVAPF of a substrate were measured after the substrate was washed with Wash-Off Composition 1 Example 2: The SPF and UVAPF of a substrate were measured after the substrate was washed with Wash-Off Composition 2 Example 3: After applying Leave-On Composition 3, the SPF and UVAPF of the substrates were measured.

[0084] Example 4: The SPF and UVAPF of the substrates were measured after applying Leave-On Composition 4.

[0085] Example 5: After applying Leave-On Composition 5, the SPF and UVAPF of the substrates were measured.

[0086] Example 6: The SPF and UVAPF of a substrate were measured after cleaning the substrate with Composition 1 followed by application of Leave-on Composition 3.

[0087] Example 7: The SPF and UVAPF of a substrate were measured after cleaning the substrate with Composition 1 followed by application of Leave-on Composition 4.

[0088] Example 8: The SPF and UVAPF of a substrate were measured after cleaning the substrate with Composition 1 followed by application of Leave-on Composition 5.

[0089] Example 9: The SPF and UVAPF of a substrate were measured after cleaning the substrate with Composition 2 followed by application of Leave-on Composition 3.

[0090] Example 10: The SPF and UVAPF of a substrate were measured after cleaning the substrate with composition 2 followed by application of leave-on composition 4.

[0091] Example 11: The SPF and UVAPF of a substrate were measured after cleaning the substrate with Composition 2 followed by application of Leave-on Composition 5.

[0092] The SPF and UVAPF of the various examples listed above were measured and the data is summarized in Table 3 below. [Table 3] The data in Table 3 above demonstrate that the method according to the present invention (Examples 6-11) provides synergistic improvements in SPF and UVAPF over the individual steps of the method (Examples 1-5).

Claims

1. 1. A method of providing a high SPF to a topical body surface, comprising: (a) cleaning the surface with a wash-off composition produced as a foam from a container equipped with a pump, the wash-off composition comprising: (i) 0.1 to 10 wt. % of a water-soluble UVA sunscreen; (ii) 0.1 to 10 wt. % of a water-soluble UVB sunscreen; and (iii) 3 to 80 wt. %, preferably 6 to 80 wt. %, of a mild surfactant selected from one or more of anionic, zwitterionic, and nonionic surfactants; (iv) a cosmetically acceptable carrier; and and preferably diluted with water, followed by a washing step (b) rinsing the surface with water, followed by (c) applying to said surface a leave-on composition comprising a sunscreen and a cosmetically acceptable vehicle; A method comprising:

2. 10. The method of claim 1, wherein the anionic surfactant is selected from one or more of isethionate, glycinate, cocoate, olefin sulfonate, sulfoacetate, and sulfosuccinate surfactants.

3. 10. The method of claim 1, wherein the zwitterionic surfactant is selected from one or more of sultaine, betaine, and amphoacetate surfactants.

4. 10. The method of claim 1, wherein the non-ionic surfactant is selected from one or more of polysorbate, sorbitan, polyethylene glycol, and glucoside surfactants.

5. 5. The method of any one of claims 1 to 4, wherein the water-soluble UVA sunscreen and the water-soluble UVB sunscreen have a water solubility of greater than 10 g / l at 25°C.

6. 6. The method of any one of claims 1 to 5, wherein the water-soluble UVB sunscreen is selected from phenylbenzimidazole sulfonic acid or benzylidene camphor sulfonic acid or mixtures thereof.

7. 7. The method of any one of claims 1 to 6, wherein the water-soluble UVA sunscreen is selected from disodium phenyldibenzimidazole tetrasulfonate, terephthalylidene dicamphor sulfonic acid, or mixtures thereof.

8. 8. The method of any one of claims 1 to 7, wherein the sunscreen in the leave-on composition is an organic UVA sunscreen, an organic UVB sunscreen, an inorganic sunscreen or a mixture thereof, preferably a combination of an organic UVB sunscreen and an organic UVA sunscreen.

9. 9. The method of claim 8, wherein the organic UVA sunscreen is butyl methoxydibenzoylmethane or diethylamino hydroxybenzoyl hexyl benzoate, the organic UVB sunscreen is ethylhexyl methoxycinnamate, octocrylene, phenylbenzimidazole sulfonic acid or ethylhexyl salicylate, and the inorganic sunscreen is zinc oxide or titanium dioxide.

10. 10. The method of any one of claims 1 to 9, wherein the cosmetically acceptable vehicle of the leave-on composition is in the form of a cream, stick, lotion, gel, or spray.

11. 11. The method of any one of claims 1 to 10, wherein the step of applying the leave-on composition is performed 1 minute to 1 hour after the step of rinsing the surface with water.

12. 12. The method according to any one of claims 1 to 11, for obtaining an SPF of at least 10.

13. (a) a handheld container equipped with a pump capable of generating a foam, containing a wash-off composition comprising 0.1 to 10% by weight of a water-soluble UVA sunscreen, 0.1 to 10% by weight of a water-soluble UVB sunscreen, 3 to 80% by weight, preferably 6 to 80% by weight of a mild surfactant selected from one or more of anionic, zwitterionic, or nonionic surfactants, and a cosmetically acceptable carrier; (b) a leave-on composition comprising a sunscreen and a cosmetically acceptable vehicle; (c) Instructions for use and A kit comprising:

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