System for suggesting treatment options

Abstract

To provide a system for appropriately proposing treatment choices in consideration of gene abnormality.SOLUTION: A system 1 for proposing treatment options includes a patient information input unit 3 to which patient information including clinical information of a patient is input, a genetic abnormality information input unit 5 to which information on a genetic abnormality of the patient is input, an evidence information recording unit 7 that records the patient information and evidence information related to the genetic abnormality, an evidence information extraction unit 9 that extracts first evidence information, which is evidence information related to the patient, from the evidence information recording unit using the patient information of a certain patient input from the patient information input unit and the information on the genetic abnormality of the patient input from the genetic abnormality information input unit, an evidence information display unit 11 for displaying the first evidence information on a display unit, and a treatment option proposal unit 13 that proposes treatment options based on the patient information using the first evidence information.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The present invention relates to a computer-based system for suggesting treatment options. [Background technology]

[0002] Published Japanese Patent Application No. 2018-533123 describes an informatics platform for integrated clinical care. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Special Publication No. 2018-533123 Summary of the Invention [Problem to be solved by the invention]

[0004] The above-mentioned informatics platform cannot properly consider treatment options based on genetic abnormalities. Furthermore, the above-mentioned informatics platform cannot properly evaluate treatment options. Therefore, the present invention aims to provide a system that can properly propose treatment options that take genetic abnormalities into account. [Means for solving the problem]

[0005] This invention is based on the finding that, essentially, treatment options are evaluated based on information about genetic abnormalities, and that by introducing indicators for ranking (evaluating) the evidence information that forms the basis of treatment options, treatment options based on genetic abnormalities can be appropriately proposed.

[0006] The present invention comprises a patient information input unit 3 to which patient information including clinical information of the patient is input; a genetic abnormality information input unit 5 into which information regarding a patient's genetic abnormality is input; an evidence information recording unit 7 for recording patient information and evidence information related to genetic abnormalities; an evidence information extraction unit 9 that extracts first evidence information, which is evidence information related to a patient, from the evidence information recording unit using patient information about a certain patient input from the patient information input unit and information about the patient's genetic abnormality input from the genetic abnormality information input unit; an evidence information display unit 11 for displaying the first evidence information on a display unit; a treatment option suggestion unit (13) that uses the first evidence information to suggest treatment options based on patient information; This is a system for suggesting treatment options.

[0007] A preferred embodiment of the present invention is further comprising a selection display unit that enables selection of evidence information displayed on the display unit, The treatment option suggestion unit is a system that uses the evidence information selected by the selection display unit as first evidence information.

[0008] A preferred embodiment of the present invention is further comprising an evidence information input unit for inputting second evidence information which is new evidence information, the evidence information display unit displays the second evidence information in addition to the first evidence information; The treatment option proposing unit is a system that uses the first evidence information and the second evidence information to propose treatment options based on patient information.

[0009] A preferred embodiment of the present invention is The patient's clinical information includes information about the type of tumor the patient has, Evidence information is a system that includes information on each tumor type.

[0010] A preferred embodiment of the present invention is The patient information is a system that includes one or more of information about the patient's specimen, information about the patient's gender, and information about the patient's medical history.

[0011] A preferred embodiment of the present invention is Treatment options include initiation of anticancer drug therapy.

[0012] A preferred embodiment of the present invention is Evidence information is classified into two or more of the following categories: (i) guideline publication information, (ii) approved drug information, (iii) clinical trial and trial information, (iv) paper information, and (v) academic conference presentation information. The treatment option suggestion part is a system that uses categories to suggest treatment options based on patient information.

[0013] A preferred embodiment of the present invention is a program for causing a computer to function as any of the above-mentioned systems. [Effects of the Invention]

[0014] This invention takes into account evidence based on genetic abnormalities and also introduces indicators for the evidence, making it possible to appropriately propose treatment options. [Brief explanation of the drawings]

[0015] [Figure 1] FIG. 1 is a block diagram showing an example of the basic configuration of a system according to the present invention. [Figure 2] FIG. 2 is a block diagram showing the basic configuration of a computer. [Figure 3] FIG. 3 is a conceptual diagram showing an example of a system according to the present invention. [Figure 4] FIG. 4 is a flowchart for explaining the processing. DETAILED DESCRIPTION OF THE INVENTION

[0016] The following describes embodiments of the present invention with reference to the drawings. The present invention is not limited to the embodiments described below, and also includes appropriate modifications of the embodiments below within the scope obvious to those skilled in the art.

[0017] 1 is a block diagram showing an example of the basic configuration of a system for proposing treatment options according to the present invention. The system 1 for proposing treatment options is a computer-based system for proposing treatment options to subjects such as doctors and patients. Examples of treatment options, for example for a tumor, are initiation of anticancer drug treatment, discontinuation of anticancer drug treatment, change of anticancer drug, clinical trial referral, and clinical trial referral.

[0018] As shown in Figure 1, the system 1 for proposing treatment options includes a patient information input unit 3, a genetic abnormality information input unit 5, an evidence information recording unit 7, an evidence information extraction unit 9, an evidence information display unit 11, and a treatment option proposing unit 13. This system 1 may further include either or both of a selection display unit 15 and an evidence information input unit 17. This system may also include a display unit 19, an interface unit 21, and a temporary storage unit 23. This system includes a computer, and each of the elements described below is implemented by the computer. The computer may be any of various terminals, mobile terminals, laptop computers, personal computers, and servers.

[0019] FIG. 2 is a block diagram showing the basic configuration of a computer. As shown in this diagram, the computer has an input unit 31, an output unit 33, a control unit 35, a calculation unit 37, and a memory unit 39, and each element is connected by a bus 41 or the like so as to be able to exchange information. For example, the memory unit may store a control program or various information. When predetermined information is input from the input unit, the control unit reads out the control program stored in the memory unit. The control unit then reads out the information stored in the memory unit as appropriate and transmits it to the calculation unit. The control unit also transmits the input information as appropriate to the calculation unit. The calculation unit performs calculation processing using the various pieces of information it receives and stores the results in the memory unit. The control unit reads out the calculation results stored in the memory unit and outputs them from the output unit. In this way, various processes are executed. Each element described below may correspond to any element of a computer.

[0020] FIG. 3 is a conceptual diagram showing an example of a system of the present invention. As shown in FIG. 3, the system of the present invention may include a mobile terminal 45 connected to the Internet or an intranet 43 and a server 47 connected to the Internet or an intranet 43. Of course, a single computer or mobile terminal may function as the device of the present invention, or multiple servers may exist. As shown in FIG. 3, the system 1 for proposing treatment options may be a server-client system or a standalone system. In addition, various information may be displayed on the display of a computer or on the display of a mobile terminal such as a tablet or smartphone.

[0021] The patient information input unit 3 is a part (means) for inputting patient information, including clinical information of the patient, into the system. For example, an input unit of a computer functions as the patient information input unit 3. Examples of patient information, including clinical information, include one or more of the following: the patient's name, the patient's ID (identification information), specimen information, information about the specimen in which the genetic abnormality was detected, basic patient information (personal information held by the patient such as gender and date of birth), clinical information (information indicating the patient's condition such as type of cancer, chief complaint, interview, palpation, and results of various tests such as biochemical tests and imaging tests), and patient history information (various patient histories such as medical history, hospitalization history, treatment history, and past test history). Preferred examples of patient clinical information include information about the type of tumor the patient has, which allows the system to suggest treatment options for the tumor. The patient information includes one or more of information about the patient's specimen, information about the patient's sex, and information about the patient's medical history.

[0022] The genetic abnormality information input unit 5 is a section (means) for inputting information about a patient's genetic abnormality into the system. For example, the input unit of a computer functions as the genetic abnormality information input unit 5. An example of information about a patient's genetic abnormality is information that a base located at a specific number in a certain gene has been replaced with another base.

[0023] The evidence information recording unit 7 is a unit (means) for recording patient information and evidence information related to genetic abnormalities. For example, a computer's memory unit functions as the evidence information recording unit 7. Evidence information refers to information that supports whether a certain drug or treatment method is effective or completely ineffective. Examples of evidence information include information on therapeutic drugs for specific diseases (e.g., tumors and cancers) and information on treatment methods for specific diseases. The evidence information preferably includes information for each type of tumor. Examples of evidence information are classified into two or more of the following categories: (i) guideline publication information, (ii) approved drug information, (iii) clinical trial and trial information, (iv) paper information, and (v) academic conference presentation information.

[0024] The evidence information extraction unit 9 is a part (means) for extracting first evidence information, which is evidence information related to a patient, from the evidence information recording unit 7, using patient information of a certain patient input from the patient information input unit 3 and information on the patient's genetic abnormality input from the genetic abnormality information input unit 5. For example, the evidence information recording unit 7 is functioned by a control program stored in the calculation unit, control unit, and memory unit of a computer.

[0025] The evidence information display unit 11 is a part (means) for displaying the first evidence information on the display unit. For example, the output unit of a computer functions as the display unit, and the control program stored in the calculation unit, control unit, and memory unit of the computer functions as the evidence information display unit 11.

[0026] The treatment option suggestion unit 13 is a unit (means) for suggesting treatment options based on patient information using the first evidence information. For example, a control program stored in the calculation unit, control unit, and storage unit of a computer functions as the treatment option suggestion unit 13. A preferred example of the treatment option suggestion unit 13 uses categories to suggest treatment options based on patient information.

[0027] The selection display unit 15 is a part (means) for making the evidence information displayed on the display unit selectable. For example, the calculation unit, control unit, and control program stored in the memory unit of a computer function as the selection display unit 15. In a system further having the selection display unit 15, it is preferable that the treatment option suggestion unit 13 treats the evidence information selected by the selection display unit (selection information input into the system) as the first evidence information.

[0028] The evidence information input unit 17 is a unit (means) for inputting second evidence information, which is new evidence information (evidence information different from the first evidence information). For example, the evidence information input unit 17 is functioned by a control program stored in the calculation unit, control unit, and storage unit of a computer.

[0029] In the system of this system aspect, the evidence information display unit 11 preferably displays the second evidence information in addition to the first evidence information on the display unit, and the treatment option suggestion unit 13 preferably suggests treatment options based on patient information using the first evidence information and the second evidence information.

[0030] Next, an example of the operation of this system will be explained. FIG. 4 is a flowchart for explaining the processing. Patient information is input to the system from an input unit of a computer serving as the patient information input unit 3 (patient information input step: S101). The input patient information is stored in the storage unit as appropriate. Examples of patient information include the patient's name, the patient's ID (identification information), and the patient's clinical information (tumor type: for example, "colon cancer").

[0031] Information about the genetic abnormality of the patient is input to the system from the input unit of the computer serving as the genetic abnormality information input unit 5 (genetic abnormality information input step: S102). The input information is stored in the storage unit as appropriate. For example, information that a base (e.g., T) at a specific position n in a patient's gene X has been replaced with another base (e.g., C) is entered into the system (X:TnC).

[0032] The evidence information recording unit 7 records patient information and evidence information related to genetic abnormalities. For example, for colon cancer patients in which a base (e.g., T) located at a specific number n in gene X has been replaced with another base (e.g., C), a paper stating that therapeutic drug Z is effective and guidelines for therapeutic drug Z for colon cancer are recorded in the memory unit of a server or computer that serves as the evidence information recording unit. Guidelines for therapeutic drug Z are classified into (i) guideline publication information and (ii) approved drug information. Papers stating that therapeutic drug Z is effective are classified into (iv) paper information. In this case, if there is a paper stating that therapeutic drug Y is not effective for colon cancer patients in which a base (e.g., T) located at a specific number n in gene X has been replaced with another base (e.g., C), this is stored in the memory unit as evidence information with a negative evaluation.

[0033] The evidence information extraction unit 9 uses the patient information of a certain patient input from the patient information input unit 3 and the information regarding the patient's genetic abnormality input from the genetic abnormality information input unit 5 to extract first evidence information, which is evidence information related to the patient, from the evidence information recording unit 7 (first evidence information extraction process: S103).

[0034] As explained earlier, for example, patient information such as "colon cancer" and information regarding the patient's genetic abnormality, such as "a base (e.g., T) located at a specific number n in gene X has been replaced with another base (e.g., C) (X:TnC)," are input into the system and stored in the memory unit. In response to commands from the control program stored in the memory unit, the control unit reads information regarding "colon cancer" and "X:TnC" from the memory unit, and extracts evidence information regarding either or both of "colon cancer" and "X:TnC" from the memory unit.

[0035] In this example, (i) Guideline publication information, (ii) Guideline for therapeutic drug Z classified as approved drug information (positive evidence information), (iv) A paper stating that therapeutic drug Z was effective (positive evidence information), which is classified as paper information. (iv) A paper categorized as paper information stating that therapeutic drug Y is not effective (negative evidence information) is extracted as evidence information.

[0036] The storage unit stores evidence information related to these target diseases and genetic abnormalities, so that the evidence information related to the target diseases and genetic abnormalities can be easily read out. At this time, the calculation unit may be used to perform necessary calculations. Furthermore, the read evidence information (first evidence information) may be temporarily stored in the storage unit.

[0037] The arithmetic unit, control unit, and storage unit of the computer functioning as the evidence information display unit 11 perform image processing to display the first evidence information on the computer monitor or the screen (display unit) of the mobile terminal (evidence information display processing step: S104). This image processing can be performed by the control unit receiving a command from the control program stored in the storage unit causing the arithmetic unit to perform the necessary arithmetic processing and reading out information necessary for screen display from the storage unit as appropriate.

[0038] In the above example, the display unit displays the guidelines for therapeutic drug Z and a paper stating that therapeutic drug Z is effective as evidence information. Note that a paper stating that therapeutic drug Y is not effective may also be displayed as negative evidence information on the display unit.

[0039] The calculation unit, control unit, and storage unit of the computer functioning as the treatment option proposing unit 13 use the first evidence information to propose treatment options based on the patient information (treatment option proposing step: S105). Specifically, the treatment options may be read from the storage unit and displayed on the display unit. At this time, evidence information related to the treatment options may also be displayed on the display unit.

[0040] In the above example, for example, the indicator (evaluation score) is assigned a + or - depending on whether the evidence information is positive or negative, and the evaluation score is assigned based on one of the following information: (i) guideline publication information, (ii) approved drug information, (iii) clinical trial / trial information, (iv) paper information, or (v) academic conference presentation information. In the above example of the patient, the information "colon cancer" and "X: TnC" are entered into the system, and for therapeutic drug Z, there is (i) guideline publication information, (ii) approved drug information, and (iv) paper information, so the evaluation points assigned to these are added up. It is also possible to add up based on the amount of evidence information. This processing can be performed by the control unit receiving commands from the control program stored in the memory unit, causing the calculation unit to perform the necessary calculation processing, and by reading out information required for the calculation processing (for example, coefficients and numerical values) from the memory unit as appropriate.

[0041] In addition, the therapeutic drug Y will be required to be evaluated as ineffective (negative evaluation).

[0042] Then, in this example, the computer functioning as the treatment option suggestion unit 13 extracts the start of anticancer drug treatment using therapeutic drug Z and displays it on the display unit. At this time, the above guidelines and papers may also be displayed as evidence information so that they can be seen. In this example, initiation of anticancer drug treatment with drug Z was proposed as a treatment option. On the other hand, if the evidence information recording section records information on drugs other than therapeutic drug Z related to "colon cancer" and "X:TnC" or treatment methods, these treatment options may also be displayed on the display section. Furthermore, for example, when information indicating that drug therapy with therapeutic drug Y is currently being administered is entered into the system as patient information, "changing anticancer drugs" may be proposed as a treatment option. In this case, the display unit may be configured to display either or both of the evidence information regarding therapeutic drug Z and therapeutic drug Y and the above-mentioned evaluation values.

[0043] In this way, the system will be able to suggest treatment options based on the patient's genetic abnormalities.

[0044] Next, another aspect of this system will be described. In this example, the system further includes a selection display unit 15. A control program stored in the calculation unit, control unit, and storage unit of the computer that functions as the selection display unit 15 selectably displays the evidence information selected by the selection display unit.

[0045] for example, Guidelines for therapeutic drug Z (positive evidence information), A paper stating that drug Z was effective (positive evidence), and Papers (negative evidence information) that indicate that therapeutic drug Y is not effective are displayed on the display unit, and check boxes are displayed before the display of this information. For example, when a check box is entered in a paper (positive evidence information) that states that therapeutic drug Z is effective, the paper (positive evidence information) that states that therapeutic drug Z is effective from the evidence information is erased from the display section. In this case, the guidelines for therapeutic drug Z (positive evidence information), and There is a paper (negative evidence) that says that drug Y is not effective. This may be considered as first evidence information.

[0046] In this aspect, when the evidence information is displayed on the display unit, the reason for the recommendation or non-recommendation may also be displayed together with whether each piece of evidence is recommended or non-recommended. Furthermore, if certain evidence information is non-recommended, the non-recommended evidence information may also be displayed, but the recommended evidence information may be displayed in a selected state, and the non-recommended evidence information may be displayed in an unselected state.

[0047] For example, if a paper stating that therapeutic drug Y is not effective is stored in the memory unit as being non-recommended, the control unit reads information about the non-recommended drug from the memory unit, Guidelines for therapeutic drug Z (positive evidence information), Articles showing that therapeutic drug Z was effective (positive evidence information), and are displayed in a pre-selected state (for example, displayed with a check mark in the checkbox), Papers that state that therapeutic drug Y is not effective (negative evidence information) may be displayed in a pre-selected state (for example, displayed with the checkbox unchecked).

[0048] Next, another aspect of this system will be described. This embodiment further includes an evidence information input unit 17 . In this case, second evidence information, which is new evidence information (evidence information different from the first evidence information), is input to the system from an input unit of a certain terminal. For example, authenticated drug information regarding therapeutic drug Z is input into the system from an input unit of a certain terminal. Then, the authenticated drug information regarding therapeutic drug Z (positive evidence information) is stored in the storage unit as second evidence information.

[0049] In the system of this system aspect, the evidence information display unit 11 displays the second evidence information on the display unit in addition to the first evidence information. In this case, for example, guidelines for therapeutic drug Z (positive evidence information), A paper stating that treatment drug Z was effective (positive evidence information), Certified drug information (positive evidence information) regarding therapeutic drug Z and A paper (negative evidence information) stating that therapeutic drug Y is not effective may be displayed on the display unit. In this embodiment of the system, it is preferable that the treatment option suggestion unit 13 suggests treatment options based on patient information using information including first evidence information and second evidence information (authenticated drug information regarding therapeutic drug Z).

[0050] Another aspect of the present invention relates to a program for causing a computer to function as any of the above systems. This specification also provides a computer-readable information recording medium (floppy disk, CD, DVD, USB memory, or hard disk) that stores such a program. [Example]

[0051] In order to provide appropriate treatment based on the interpretation of genetic abnormalities detected through gene panel testing, exome analysis, whole genome analysis, etc., performed on samples such as removed tumors, blood, and body fluids, a process of clinical significance based on evidence-based information linking genetic abnormalities with treatment options based on that interpretation is necessary. In addition, additional patient-derived information may be used as necessary to provide appropriate clinical significance tailored to individual patients.

[0052] Currently, such clinical significance is determined by experts or expert panels composed of experts, but this process requires the collection and organization of evidence-based information, which is a tedious task. The proposed method is intended to enable efficient selection of appropriate treatments based on the interpretation of these genetic abnormalities.

[0053] Examples of patient-derived information that may be included include: Specimen information Information on genetic abnormalities detected in the specimen Basic patient information (personal information held by the patient, such as gender and date of birth) Patient clinical information (information showing the patient's condition, such as type of cancer, chief complaint, interview, palpation, and results of various tests such as biochemical tests and imaging tests) Patient history information (various patient histories such as medical history, hospitalization history, treatment history, and past examination history)

[0054] Possible treatment options include, for example: ·Start of anti-cancer drug treatment -Discontinuation of anti-cancer drug treatment Change of anticancer drug Clinical trials and clinical trial introductions

[0055] Examples of evidence linking suspected genetic abnormalities to treatment options based on their interpretation include the following: Guideline information Approved Drug Information Clinical trial and trial information Paper information Conference presentation information

[0056] For example, when proposing potential treatment options for a patient with non-small cell lung cancer in which an exon 19 deletion of the EGFR gene has been detected, a candidate drug would be "dacomitinib," which is approved by the FDA and has the following statement in its package insert: "a kinase inhibitor indicated for the first-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 19 deletion or exon 21 L858R substitution mutations as detected by an FDA-approved test." This information serves as the basis for linking this genetic abnormality to treatment options based on its interpretation. Furthermore, since the deletion of exon 19 of the EGFR gene is known as a positive mutation in the EGFR gene, it is also a candidate for, for example, "dacomitinib hydrate tablets," which have been approved by the PMDA for efficacy and effectiveness in treating "inoperable or recurrent non-small cell lung cancer that is positive for the EGFR gene mutation" and for which this statement is included in the drug's package insert.

[0057] As another example, when proposing potential treatment options for patients with non-small cell lung cancer in which an EGFR exon 19 deletion and a T790M mutation have been detected, for example, a "randomized phase II trial of osimertinib + ramucirumab versus osimertinib as initial chemotherapy for EGFR gene mutation-positive non-squamous non-small cell lung cancer" would be a candidate for evidence linking genetic abnormalities to treatment options based on their interpretation, since the inclusion criteria for the trial include "a histological or cytological diagnosis of non-squamous non-small cell lung cancer" and "confirmed EGFR mutation (exon 19 deletion, L858R) in tissue or cytology samples (excluding patients with known T790M positivity)." However, if the T790M mutation had not been detected, the patient would not meet the inclusion criteria for the clinical trial, and therefore it is desirable not to propose this as a candidate for evidence linking genetic abnormalities to treatment options based on their interpretation.

[0058] In this way, evidence-based information linking one or more genetic abnormalities in a patient with treatment options based on their interpretation is proposed by comprehensively evaluating patient-derived information as needed.

[0059] However, since it is anticipated that even after collecting this information, the latest evidence information may not be proposed, the proposed method allows the expert panel participants or the attending physician who assigns clinical significance to check each piece of proposed evidence information displayed on the screen and decide whether or not to use it in their final decision.

[0060] When expert panel participants or attending physicians who assign clinical significance perform this confirmation, it is desirable to be able to confirm the evidence using information about one or more genetic abnormalities in a patient, as well as a large amount of patient-derived information such as cancer type, gender, age, and other information. However, displaying all of this information on a single screen would make the screen too cluttered and make the confirmation process difficult.

[0061] Therefore, the proposed method displays information about each individual genetic abnormality in a patient and patient-derived information on a single screen. This display makes it easier to confirm treatment options and evidence for each genetic mutation.

[0062] On the other hand, in such a system where information about individual genetic abnormalities in a single patient and patient-derived information are displayed on a single screen, situations can arise where the supporting information is suppressed because it is not displayed on the screen.

[0063] For example, in the case of the patient with an exon 19 deletion and a T790M mutation in the EGFR gene in the example above, the page displaying information about the exon 19 deletion in the EGFR gene does not indicate that the patient also has the T790M mutation. However, due to the condition "However, patients known to be T790M positive will be excluded," a situation occurs in which, based only on the mutation of exon 19 deletion that is displayed, clinical trials that should seemingly be eligible for the patient are not suggested as candidates.

[0064] Therefore, in the proposed method, if a situation arises in which evidence information is not proposed based on genetic abnormalities or other patient-derived information that is not displayed on the screen, it is possible to display the evidence information as evidence information in a state where the evidence information has been rejected.In addition, by also displaying the reason for displaying the information in a rejected state (in this case, the T790M mutation exists separately and should be excluded), the reason for rejection as evidence can be easily confirmed. [Industrial Applicability]

[0065] Since this invention is a system for providing medical information, it can be used in the information equipment industry for medical institutions. [Explanation of symbols]

[0066] 1. A system for proposing treatment options 3. Patient information input section 5 Genetic abnormality information input section 7 Evidence Information Recording Section 9. Evidence information extraction unit 11 Evidence information display section 13 Treatment Option Suggestion Section 15 Selection display section 17 Evidence information input section

Claims

1. a patient information input unit into which patient information including clinical information of the patient is input; a genetic abnormality information input unit into which information regarding a patient's genetic abnormality is input; an evidence information recording unit that records patient information and evidence information related to genetic abnormalities; an evidence information extraction unit that extracts first evidence information, which is evidence information related to a certain patient, from the evidence information recording unit using patient information of the certain patient input from the patient information input unit and information on the genetic abnormality of the certain patient input from the genetic abnormality information input unit; an evidence information display unit for displaying the first evidence information on a display unit; a treatment option suggestion unit that uses first evidence information to suggest treatment options based on the patient information, The treatment option suggestion unit excludes a certain treatment method that should be discouraged from the treatment options to be proposed to the patient based on abnormality information of a certain gene that is grounds for discontinuing the certain treatment method as a treatment option, the evidence information display unit displays the treatment options to be proposed to the patient; The treatment method to be discouraged is displayed separately from the treatment options to be proposed to the patient. A system for suggesting treatment options.

2. 2. The system of claim 1, The display device further includes a selection display unit that allows selection of the evidence information displayed on the display unit, the treatment option suggestion unit sets the evidence information selected by the selection display unit as first evidence information; system.

3. 3. The system according to claim 1 or 2, further comprising an evidence information input unit for inputting second evidence information which is new evidence information; the evidence information display unit displays second evidence information in addition to the first evidence information; the treatment option proposing unit uses first evidence information and second evidence information to propose treatment options based on the patient information; system.

4. The system according to any one of claims 1 to 3, the patient's clinical information includes information regarding the type of tumor the patient is suffering from; The evidence information includes information for each tumor type, system.

5. The system according to any one of claims 1 to 4, The patient information includes one or more of information about the patient's specimen, information about the patient's gender, and information about the patient's medical history.

6. A system according to any one of claims 1 to 5, The treatment options include initiation of anti-cancer drug treatment.

7. 2. The system of claim 1, The evidence information is classified into two or more categories of (i) guideline publication information, (ii) approved drug information, (iii) clinical trial information, (iv) paper information, and (v) academic conference presentation information, the treatment option suggestion unit uses the categories to suggest treatment options based on the patient information; system.

8. A program for causing a computer to function as the system according to claim 1.

Images