A device to activate mitochondria
The device enhances mitochondrial activation and ATP production by supplying negative charges and reactive oxygen species and facilitating calcium ion entry, addressing the inefficiencies in existing methods to maintain cellular energy balance.
Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Filing Date
- 2024-11-15
- Publication Date
- 2026-03-27
AI Technical Summary
Existing methods fail to effectively supply negative charges and reactive oxygen species to mitochondria, and facilitate the entry of calcium ions into the mitochondrial matrix, thereby hindering mitochondrial activation and ATP production, which is crucial for maintaining cellular energy balance.
A device that supplies negative charges and reactive oxygen species to mitochondria via a supply unit and promotes calcium ion entry through a calcium ion channel unit, utilizing a low-temperature plasma generator and far-infrared generator to enhance mitochondrial oxidative phosphorylation and ATP production.
Regulates calcium ions, promotes oxidative phosphorylation, increases ATP synthesis, and maintains cellular energy balance by activating mitochondria through the supply of negative charges and reactive oxygen species and calcium ions.
Smart Images
Figure 2026054541000001_ABST
Abstract
Description
Technical Field
[0001] The present invention activates mitochondria Device and particularly relates to a method for supplying negative charges and reactive oxygen species to mitochondria from outside the body via a negative charge and reactive oxygen species supply unit. And through a calcium ion channel promoting unit, calcium ions in the body enter the mitochondrial matrix space through a calcium transport protein on the inner mitochondrial membrane, promoting the activation of mitochondria and the production of ATP.
Background Art
[0002] According to that, mitochondria are the units of energy production in cells and are the energy factories of cells. Each mitochondrion is composed of an outer membrane and an inner membrane, and the space surrounded by the inner membrane is called the matrix space. Enzymes related to biological oxidation reactions are embedded in the outer membrane of mitochondria and serve as raw materials for internal reactions in mitochondria. The matrix space inside mitochondria contains enzymes that metabolize carbohydrates, proteins, and fat products into H2O and CO2 through the citric acid cycle. In this process, electrons move through the respiratory enzyme chain, and adenosine triphosphate (abbreviation: ATP), a high-energy phosphate compound, is synthesized using oxidative phosphorylation. ATP is the main energy source for energy-consuming reactions in plants and animals. This ATP is a biochemical nucleotide that functions as an "energy currency" for energy transfer, storage, and transfer within cells. ATP also plays an important role in nucleic acid synthesis. It is also the guanine dinucleotide of the RNA sequence and can be used as an alternative to DNA transcription.
[0003] However, mitochondria need to continuously perform oxidation-reduction reactions to generate energy. The triggers for these oxidation-reduction reactions depend on negative charges (-e) and reactive oxygen species (O), which serve as the raw materials for mitochondria to act upon. Providing these raw materials can further activate mitochondria. Furthermore, the influx of calcium ions plays the following important roles in mitochondrial activation and ATP production.
[0004] 1. Regulation of calcium ions in mitochondria: Calcium can enter mitochondria and influence their function. When calcium concentration in the cytoplasm increases, calcium ions pass through calcium on the inner mitochondrial membrane, transporting proteins into the mitochondrial matrix space. This influx of calcium ions promotes mitochondrial depolarization, thereby increasing mitochondrial oxidative phosphorylation activity.
[0005] 2. Promote oxidative phosphorylation: An increase in calcium ions can activate various mitochondrial enzyme systems, including key enzymes in the tricarboxylic acid cycle (TCA). This activation allows mitochondria to accelerate substrate oxidation, improve electron transport chain efficiency, and ultimately increase ATP production.
[0006] 3. Increased ATP synthesis: An increase in calcium concentration within mitochondria increases the rates of the tricarboxylic acid cycle (TCA cycle) and oxidative phosphorylation. Oxidative phosphorylation, described above, is a cellular metabolic pathway that occurs in the inner mitochondrial membrane of eukaryotes or the cell membrane of prokaryotes. It synthesizes adenosine triphosphate (ATP) using energy released by oxidizing enzymes and various nutrients, directly increasing ATP production. ATP production is driven by the action of the electron transport chain and facilitated by calcium ions. These processes ensure the continuity and efficiency of ATP production.
[0007] 4. Maintaining cellular energy balance: Increased ATP production helps cells maintain energy balance, especially when responding to various stresses. This also aids in cell repair and normalization to avoid cell death due to energy deficiency.
[0008] Therefore, when negative charges (-e) and reactive oxygen species (O), which are necessary for mitochondrial redox reactions, are continuously supplied from the outside, and calcium ions from within the body are facilitated to enter the mitochondrial matrix space via calcium transport proteins in the inner mitochondrial membrane, mitochondrial activation and ATP production are promoted. [Overview of the project] [Problems that the invention aims to solve]
[0009] The main objective of the present invention is to activate mitochondria, which can enhance mitochondrial activation and ATP production. Device The objective is to provide. [Means for solving the problem]
[0010] The main features of this invention are as follows: Negative charge and reactive oxygen species are supplied to mitochondria from the outside via a negative charge and reactive oxygen species supply unit, as raw materials for mitochondrial redox reactions. . Calcium ions in the body enter the mitochondrial matrix space via calcium ion channel-facilitating units, mediated by calcium transport proteins on the inner mitochondrial membrane. This influx of calcium ions promotes mitochondrial depolarization and enhances mitochondrial oxidative phosphorylation activity. This, in turn, promotes mitochondrial activation and ATP production.
[0011] To achieve the above objectives and effectiveness, the following embodiments of the technical means used in the present invention are described. [Effects of the Invention]
[0012] 1. It can regulate calcium ions in mitochondria. 2. Promotes oxidative phosphorylation. 3. ATP synthesis increases. 4. Maintain the energy balance of cells. [Brief explanation of the drawing]
[0013] [Figure 1] This is a block diagram of a preferred embodiment of the present invention. [Modes for carrying out the invention]
[0014] Please refer to Figure 1. Activating mitochondria in a preferred embodiment of the present invention. Device The following applies:
[0015] It supplies negative charge (-e) and reactive oxygen species (O) to mitochondria. . The negative charge and reactive oxygen species are supplied to the mitochondria from the outside through the negative charge and reactive oxygen species supply unit 1, and become raw materials for mitochondrial oxidation-reduction. The negative charge and reactive oxygen species supply unit 1 can be achieved by energizing a low-temperature plasma generator. When the low-temperature plasma generator is energized, a large amount of negative charge (-e) and reactive oxygen species (O) are generated, and a large amount of negative charge (-e) and reactive oxygen species (O) enter the body as raw materials for mitochondrial oxidation-reduction.
[0016] Supply calcium ions to mitochondria. Through the calcium ion channel promoting unit 2, calcium ions in the body are promoted to enter the matrix space of mitochondria through the calcium transport protein on the inner mitochondrial membrane, and the influx of calcium ions promotes the depolarization of mitochondria. The calcium ion channel promoting unit 2 can be a far-infrared generator with a power of 500 watts or more. By irradiating the body through the far-infrared generator, calcium ions in the body are promoted to enter the matrix space of mitochondria through the calcium transport protein on the inner mitochondrial membrane.
[0017] Through the negative charge and reactive oxygen species supply unit 1 Provide sufficient negative charges (-e) and reactive oxygen species (O) raw materials to mitochondria. Next, through step 2, through the calcium ion channel promoting unit 2, calcium ions in the body are promoted to enter the matrix space of mitochondria by the calcium transport protein on the inner mitochondrial membrane, and the influx of calcium ions promotes the depolarization of mitochondria, which can promote the activation of mitochondria and the generation of ATP.
[0018] Next, the present invention tested the mitochondrial activation of peripheral blood mononuclear cells of test subjects A, B, and C before the use of the present invention, 1 hour after the second use, and 1 hour after the fourth use through Taiwan Mitochondrial Application Technology Co., Ltd. The test results are described in the first, second, and third measurement time points in Table 1. As shown in Table 1, in all subjects, it shows that mitochondria are clearly activated after the application of the present invention, proving that the present invention is clearly effective and has industrial utilization.
Table 1
[0019] The present invention has been described above by way of embodiments, but the present invention is not limited to the above embodiments, and can be implemented with various modifications without departing from the gist of the present invention. Therefore, the scope of the present invention is defined by the appended claims.
Description of Reference Numerals
[0020] 1 Negative charge and active oxygen supply unit 2 Calcium ion channel promoting unit
Claims
1. A method for activating mitochondria, Step 1 supplies negative charge and reactive oxygen species to the mitochondria. The aforementioned negative charge and reactive oxygen species are supplied to the mitochondria from the outside through the negative charge and reactive oxygen species supply unit, and become raw materials for mitochondrial oxidation-reduction. Step 2 involves supplying calcium ions to the mitochondria. A method for activating mitochondria, characterized in that, through a calcium ion channel promoting unit, calcium ions in the body are promoted to enter the mitochondrial matrix space via calcium transport proteins on the inner mitochondrial membrane, and the influx of calcium ions promotes mitochondrial depolarization, thereby improving mitochondrial oxidative phosphorylation activity.
2. The method for activating mitochondria according to claim 1, characterized in that the negative charge and reactive oxygen supply unit is a low-temperature plasma generator.
3. The method for activating mitochondria according to claim 1 or 2, characterized in that the calcium ion channel promoting unit is a far-infrared generator having a power of 500 watts or more.