UV radiation device and method of use

Abstract

The present invention provides a device, system, and method of using the same that can safely and effectively transmit therapeutic or germicidal ultraviolet (UV) radiation, such as UVC radiation or UVA radiation. [Solution] The treatment device comprises a base component and a head component. The head component has a distal portion and a proximal portion. The distal portion of the head component is configured to contact the target eyelid, and the proximal portion is configured to be attached to the base component. The distal portion of the head component is configured to transmit a therapeutic dose of energy from a plurality of energy sources, including an ultraviolet C (UVC) radiation source, an infrared (IR) radiation source, and an ultrasonic source. The plurality of energy sources are configured to transmit a therapeutic dose of energy to the target eyelid at a predetermined output when the distal portion of the head component contacts the eyelid.

Description

[Technical Field]

[0001] This disclosure relates to a UV radiation device and a method for using the same. [Background technology]

[0002] By using ultraviolet (UV) radiation of the appropriate intensity, energy, and wavelength, unwanted cells or microorganisms can be inactivated or killed without causing significant damage to surrounding healthy cells. However, irradiating the right site with UV radiation at the right time has proven to be a challenging task. Therefore, new devices and methods are needed for delivering UV radiation for multiple indications. [Prior art documents] [Patent Documents]

[0003] [Patent Document 1] Special Publication No. 2019-530559 [Overview of the project] [Problems that the invention aims to solve]

[0004] This specification describes apparatus, methods, and systems useful for delivering therapeutic and germicidal ultraviolet (UV) radiation. Furthermore, infrared, heat, and ultrasound are optionally delivered using the apparatus described herein in configurations for treating various diseases. The described apparatus, methods, and systems are configured to sterilize tissues and surfaces such as contact lenses and eyeglasses. [Means for solving the problem]

[0005] Accordingly, in one embodiment, the present invention is characterized by a therapeutic device comprising a base component and a head component, the head component having a distal portion and a proximal portion, the distal portion of the head component configured to contact the target eyelid, and the proximal portion of the head component configured to be attached to the base component. The distal portion of the head component can be configured to transmit therapeutic dose energy from a plurality of energy sources comprising a far ultraviolet (UVC) radiation source, an infrared (IR) radiation source, and an ultrasonic source. The plurality of energy sources can be configured to transmit therapeutic dose energy to the target eyelid at a predetermined output (predetermined power) when the distal portion of the head component contacts the eyelid.

[0006] In some embodiments, the device further includes a temperature sensor. The device may further include a heat source. An infrared radiation source may be configured to provide heat. In some embodiments, the heat source includes a resistive wire element. In some embodiments, the device further includes a microwave radiation source. In some embodiments, the device further includes a powerful pulsed light source. In some embodiments, the device further includes a contact sensor for sensing contact between the device and the eyelid.

[0007] In another embodiment, the present invention features a therapeutic device comprising a base component and a head component, the head component having a distal portion and a proximal portion, the distal portion of the head component configured to transmit a therapeutic dose of UVC radiation from a UVC radiation source to the target eye, and the proximal portion of the head component configured to be attached to the base component. The device may further include a proximity detection element configured to detect a predetermined distance between the UVC radiation source and the treatment site of the eye. The device may also include a signal generating element configured to generate a signal when the proximity detection element detects the predetermined distance, the signal configured to transmit a therapeutic dose of UVC radiation to the target eye at a predetermined output by activating the UVC radiation source. The therapeutic device may further include an optical guide having a proximal portion and a distal portion, the proximal portion of the optical guide configured to be attached to the distal portion of the head component, and the distal portion of the optical guide configured to transmit a therapeutic dose of UVC radiation.

[0008] In another embodiment, the present invention features a sterilization device comprising a base component and a head component, the head component having a distal portion and a proximal portion, the distal portion of the head component configured to transmit a germicidal dose of UVC radiation from a UVC radiation source to a target, and the proximal portion of the head component configured to be attached to the base component. The device may further comprise an optical guide having a proximal portion and a distal portion, the proximal portion of the optical guide configured to be attached to the distal portion of the head component, and the distal portion of the optical guide configured to transmit a germicidal dose of UVC radiation. The device may further comprise a proximity determination element configured to detect a predetermined distance between the distal portion of the optical guide and the treatment site of a target. The device may also comprise a signal generation element configured to generate a signal when the proximity determination element detects a predetermined distance, the signal configured to transmit a germicidal dose of UVC radiation through the optical guide at a predetermined output by activating a UVC radiation source.

[0009] In some embodiments, the head component includes an aperture control element configured to adjust the dose of UVC radiation. The aperture control element may comprise one or more removable cones. The aperture control element may be integrated within the head component. The aperture of the UVC radiation source may range from about 1 mm to about 50 mm (e.g., about 2 mm to about 40 mm, about 4 mm to about 40 mm, e.g., about 25 mm, e.g., about 4 mm).

[0010] In some embodiments of any of the above-described aspects, the UVC radiation source is configured to deliver a therapeutic dose of UVC to the anterior region, posterior region, vitreous chamber region, retinal region, choroidal region, macular region, lens region (e.g., intraocular lens region), ciliary muscle region, optic nerve region, site of injury, or site affected by a foreign body in the eye. In some embodiments, the therapeutic dose of UVC is configured to be delivered to the target eye via a vitrectomy element. In some embodiments, the UVC radiation source is configured to deliver a therapeutic dose of UVC radiation to the target eye via an optical guide that is inserted into the vitrectomy element and enters the internal region of the target eye.

[0011] In some embodiments of any of the above-described aspects, the UVC radiation source is configured to deliver a therapeutic dose of UVC to the wound. In some embodiments, the therapeutic dose of UVC improves wound healing (e.g., the rate of healing, the degree of healing, and / or scar reduction).

[0012] In some embodiments of any of the above-described aspects, the device includes an eye stabilizing element having a proximal end configured to be attached to the distal portion of the head component and a distal end configured to stabilize by contact with the eye. In some embodiments, the eye stabilizing element is conical in shape, having a first diameter at the proximal end and a second diameter at the distal end.

[0013] In some embodiments, the first diameter is smaller than the second diameter, or the first diameter is larger than the second diameter. In some embodiments, the distal portion of the eye stabilizing element comprises a plurality of teeth configured to fix the target eye. In some embodiments, the eye stabilizing element is made of a material that does not transmit UVC light. In some embodiments, the eye stabilizing element is substantially hollow, providing a volume to which the therapeutic dose of UVC radiation from the head component can move to the treatment site of the target eye. In some embodiments, the eye stabilizing element is configured to block UVC radiation from irradiating healthy areas of the target eye. In some embodiments, the eye stabilizing element is disposable. In some embodiments, the eye stabilizing element is for single use only and is equipped with a tag (e.g., radio frequency identification (RFID)) to prevent reuse of the eye stabilizing element. In some embodiments, the eye stabilizing element is not sterilizable. In some embodiments, the eye stabilizing element is made of plastic. In some embodiments, the eye stabilizing element is transparent to visible light.

[0014] In another embodiment, the present invention features a therapeutic device comprising a base component and a head component, the head component having a distal portion and a proximal portion, the distal portion of the head component configured to transmit a therapeutic dose of near-ultraviolet (UVA) radiation from a UVA radiation source to the target eye, and the proximal portion of the head component configured to be attached to the base component. The device may further comprise a proximity detection element configured to detect a predetermined distance between the UVA radiation source and the treatment site of the target. The device may also comprise a signal generating element configured to generate a signal when the proximity detection element detects the predetermined distance, the signal configured to activate the UVA radiation source and transmit a therapeutic dose of UVA radiation to the target eye at a predetermined output.

[0015] In some embodiments, the device further includes an imaging module configured to display an image of the treatment site. In some embodiments, the device is configured to be attached to a slit lamp.

[0016] In some embodiments, the device further includes a power source (e.g., a battery). In some embodiments, the device further includes a control mechanism, such as a control button. In some embodiments, the control mechanism resides on a base component.

[0017] In some embodiments, the proximity detection element comprises two or more lasers. The proximity detection element can be configured to activate a signal generation element when the two or more lasers converge.

[0018] In some embodiments, the signal generating element is configured to provide an auditory signal, a visual signal, or a tactile signal. In another embodiment, the present invention features an apparatus comprising a base component and a head component, the head component having a distal portion and a proximal portion, the distal portion of the head component configured to transmit a certain dose of UVC radiation from a UVC radiation source to a contact lens or eyeglasses, and the proximal portion of the head component configured to be attached to the base component. In some embodiments, the apparatus further comprises a contact lens or eyeglasses case equipped with an ultrasonic source, the contact lens or eyeglasses case being attached to the distal portion of the head component and configured to transmit a certain dose of ultrasound.

[0019] In another embodiment, the present invention features a system for delivering multiple energy sources to a tissue site. The system comprises a base component, the base component having a proximal portion and a distal portion, the distal portion being configured to fit into one of a plurality of interchangeable heads selected from two or more of the following: a first head equipped with a UVC radiation source; a second head equipped with an infrared (IR) radiation source; a third head equipped with an ultrasonic source; a fourth head equipped with a UVA radiation source; a fifth head equipped with a UVC radiation source, an infrared (IR) radiation source, and an ultrasonic source; and a sixth head equipped with a microwave radiation source and an intense pulsed light source. The first head may further comprise one or more of the following: a proximity detection element configured to detect a predetermined distance between the energy source and the administration site; a signal generating element configured to generate a signal when the proximity detection element detects the predetermined distance; an aperture control module for adjusting the energy dose; an optical guide; and an imaging module. In some embodiments, the system for delivering multiple energy sources to a tissue site comprises a microwave radiation source and an intense pulsed light source, and can simultaneously deliver UVC radiation, infrared (IR) radiation, ultrasonic waves, microwave radiation, and intense pulsed light. In some embodiments, a system for delivering multiple energy sources to a tissue site comprises a microwave radiation source and a high-intensity pulsed light source, which can sequentially deliver UVC radiation, infrared (IR) radiation, ultrasound, microwave radiation, and high-intensity pulsed light.

[0020] In some embodiments of any of the above aspects, the UVC radiation source comprises an LED. In some embodiments, the UVC radiation source comprises a plurality of LEDs. In some embodiments, the UVC radiation has a peak wavelength of about 100 nm to about 290 nm (e.g., about 200 nm to about 290 nm, e.g., about 220 nm to about 290 nm, e.g., about 240 nm to about 280 nm, e.g., about 250 nm to about 280 nm, or about 260 nm to about 280 nm, e.g., about 254 nm, about 265 nm, or about 275 nm). In some embodiments, the UVC radiation is about 20 mW / cm². 2 ~Approx. 1,000mW / cm 2has a radiation intensity.

[0021] In some embodiments of any of the above aspects, the UVC radiation source comprises an LED. In some embodiments, the UVA radiation source comprises a plurality (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more) of LEDs. The UVA radiation can have a wavelength of from about 315 nm to about 400 nm, such as about 365 nm or about 370 nm. In some embodiments, the UVA radiation is from about 0.5 mW / cm 2 to about 100 mW / cm 2 , such as from about 1 mW / cm 2 to about 90 mW / cm 2 , from about 2 mW / cm 2 to about 80 mW / cm 2 , from about 5 mW / cm 2 to about 70 mW / cm 2 , from about 10 mW / cm 2 to about 60 mW / cm 2 , from about 15 mW / cm 2 to about 50 mW / cm 2 , from about 20 mW / cm 2 to about 45 mW / cm 2 , from about 25 mW / cm 2 to about 35 mW / cm 2 and has a radiation intensity. In some embodiments, the head component further comprises an aperture control element configured to adjust the dose of UVA radiation.

[0022] In some embodiments, the infrared IR radiation source comprises an LED. The infrared IR radiation source can comprise a plurality of LEDs. The infrared IR radiation has a peak wavelength of from about 750 nm to about 1,000,000 nm. The infrared IR radiation can have a radiation intensity of from about 20 mW / cm 2 to about 1,000 mW / cm 2 ​​​​​​​

[0024] In some embodiments of any of the above-described models, the head component and the base component are separable. In another aspect, the present invention provides the apparatus described herein and a method for treating blepharitis or meibomian gland disease (MGD) by not only bringing the distal portion of the head component into contact with the eyelid, but also by administering a therapeutic dose of energy to the eyelid from multiple energy sources.

[0025] In some embodiments, UVC radiation, infrared (IR) radiation, ultrasound, microwave radiation, and intense pulsed light can be administered simultaneously. Alternatively, in some embodiments, UVC radiation, infrared (IR) radiation, ultrasound, microwave radiation, and intense pulsed light can be administered sequentially.

[0026] In some embodiments, the method further comprises a step of transferring heat. In another embodiment, the present invention provides the apparatus described herein and a method for treating eye infections (e.g., endophthalmitis) and cancers (e.g., eyelid cancer or eye cancer) by positioning the apparatus near a treatment site. The method may comprise the steps of detecting a predetermined distance using a proximity determination element, activating a UVC radiation source by generating a signal using a signal generation element, and administering a therapeutic dose of UVC radiation to a treatment site in the eyelid or eye.

[0027] In another embodiment, the present invention provides the apparatus described herein and a method of treating cancer by arranging the apparatus near a treatment site, detecting a predetermined distance using a proximity determination element, activating a UVC radiation source by generating a signal using a signal generation element, and administering a therapeutic dose of UVC radiation to the treatment site.

[0028] In some embodiments, the cancer is eyelid or ocular cancer. In some embodiments, the cancer is intraocular melanoma, retinoblastoma, uveal melanoma, conjunctival melanoma, orbital cancer, or adnexal cancer.

[0029] In some embodiments of any of the embodiments described herein, for example, devices and methods for treating cancer, abnormal proliferation, and / or dysplasia, which include cancer cells or precancerous cells, may be used.

[0030] In another embodiment, the present invention provides the apparatus described herein and a method for sterilizing target tissue by positioning an optical guide in close proximity to the treatment site. This method may comprise the steps of detecting a predetermined distance using a proximity determination element, activating a UVC radiation source by generating a signal using a signal generation element, and administering a therapeutic dose of UVC radiation to the treatment site of the target tissue via the optical guide.

[0031] In some embodiments, the tissue is selected from the eye, nasal cavity, oral cavity, skin tissue, and tubular lumen. In some embodiments, the subject has or is suspected of having a bacterial infection (e.g., Chlamydia trachomatis, Streptococcus pneumoniae, Haemophilus influenzae), a fungal infection, an amoeba infection, a parasitic infection (e.g., Toxocara, Toxoplasma, infectious retinitis), or a viral infection (e.g., respiratory syncytial virus, influenza virus, or SARS-CoV-2). In some embodiments, the subject has acne vulgaris and / or rosacea. In some embodiments, the subject has ulcers caused by, for example, Helicobacter pylori. In some embodiments, the subject has or is suspected of having a herpesvirus infection. In some embodiments, the subject has or is suspected of having a human immunodeficiency virus infection. In some embodiments, the herpesvirus infection is located in epithelial tissue, for example, genital tissue, lips, or other parts of the skin. In some embodiments, the subject has or is suspected of having a human papillomavirus infection. In some embodiments, human papillomavirus infection is located in the tissue of the cervix.

[0032] In another embodiment, the present invention provides an apparatus as described herein and a method for treating a corneal ectasia (e.g., keratoconus) of a subject by placing the apparatus near the treatment site, wherein the subject is administered a certain dose of a photoactivator. Suitable photoactivators include, but are not limited to, riboflavin, rose bengal, porphyrin-based photosensitizers, psoralen, quinone, anthracycline, anthracendione, xanthene, fluorescein, rhodamine, phthalein, cyanine, chalcogenapyryllium dye, triarylmethane dye, phenothiazine, phenoxazine, acridine, hypericin, nicotinamide adenine dinucleotide phosphate (NADPH), 5-aminolevulinic acid, ciprofloxacin, and quinine. The photoactivator can be administered to the treatment site. In some embodiments, the method comprises the steps of detecting a predetermined distance using a proximity determination element, activating a UVA radiation source by generating a signal using a signal generation element, and administering a therapeutic dose of UVA radiation to the treatment site of the eye.

[0033] In another embodiment, the present invention features a method for sterilizing contact lenses or eyeglasses, comprising the steps of providing the apparatus described herein, placing contact lenses or eyeglasses in a case, and administering a UVC radiation source and an ultrasonic source to the contact lenses or eyeglasses. In some embodiments, the UVC radiation and ultrasonic waves are administered simultaneously. In some embodiments, the UVC radiation and ultrasonic waves are administered sequentially.

[0034] In another embodiment, the present invention features a contact lens having a proximal and distal end, configured to direct a therapeutic dose of UVC radiation from a UVC radiation source to the target eye. In some embodiments, the contact lens comprises a UVC radiation source. In some embodiments, the UVC radiation source comprises LEDs. In some embodiments, the UVC radiation source comprises a plurality of LEDs (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more). In some embodiments, the UVC radiation source comprises a plurality of surface-mount device (SMD) LEDs. In some embodiments, the plurality of LEDs are configured to be mounted on the contact lens, incorporated within the lens, or focused through the lens. In some embodiments, the proximal end of the contact lens is configured to contact the target eye, and the distal end is configured to be coupled to an external source of UVC radiation. In some embodiments, the external source of UVC radiation transmits a therapeutic dose of UVC to the distal end of the contact lens through an optical guide. In some embodiments, the UVC emission has peak wavelengths ranging from approximately 100 nm to approximately 290 nm (e.g., approximately 200 nm to approximately 290 nm, e.g., approximately 220 nm to approximately 290 nm, e.g., approximately 240 nm to 280 nm, e.g., approximately 250 nm to approximately 280 nm, or from approximately 260 nm to approximately 280 nm, e.g., approximately 254 nm, approximately 265 nm, or approximately 275 nm). In some embodiments, the UVC emission is approximately 20 mW / cm². 2 ~Approx. 1,000mW / cm 2 It has a radiant intensity of [value]. In some embodiments, the contact lens is equipped with a power source, which is a battery, an energy transfer antenna, a solar cell, an inertial power harvester, or an electrical plug.

[0035] In another embodiment, the present invention features a method for treating an eye infection, comprising the steps of providing a contact lens having a UVC radiation source as described herein, placing the contact lens on an eye infection site, and administering a therapeutic dose of UVC radiation to the eyelid or the eye treatment site.

[0036] In another aspect, the present invention provides a therapeutic apparatus as described herein and a method for treating a target wound, comprising the step of administering a therapeutic dose of UVC radiation to the wound.

[0037] <Definition> To facilitate understanding of the present invention, several terms are defined below. The terms defined herein have meanings that are generally understood by those skilled in the art relating to the present invention. Terms such as "a," "an," and "the" are not intended to refer only to singular entities, but rather to form a general class that can be used for specific examples. The terms used herein are used to describe specific embodiments of the present invention, but their use does not limit the invention except as outlined in the claims.

[0038] As used herein, the term "approximately" means a value that is within 10% of the stated value, either above or below it. As used herein, the term “cancer” refers to a disease caused by uncontrolled cell division and the ability of cells to metastasize or establish new growth in additional sites. The term cancer includes, for example, leukemia, seminoma, melanoma, teratoma, lymphoma, neuroblastoma, glioma, rectal cancer, endometrial cancer, kidney cancer, adrenal cancer, thyroid cancer, hematological cancer, skin cancer, brain cancer, cervical cancer, intestinal cancer, liver cancer, colon cancer, stomach cancer, intestinal cancer, head and neck cancer, digestive cancer, lymph node cancer, esophageal cancer, colorectal cancer, pancreatic cancer, ear, nose, and throat cancer (ENT), breast cancer, prostate cancer, uterine cancer, ovarian cancer, lung cancer and their metastases. Examples include lung carcinoma, breast carcinoma, prostate carcinoma, colon carcinoma, renal cell carcinoma, cervical carcinoma, or metastases from the above types of cancer or tumors. The term cancer according to the present invention also encompasses cancer metastases and / or cancers of surrounding tissues, such as orbital cancer or adnexal cancer. As used herein, cancer also includes neoplasia and dysplasia, for example, those comprising cancerous and precancerous cells or tissues.

[0039] As used herein, the term "sterilizing dose of energy" refers to an amount of electromagnetic energy (e.g., UV), mechanical energy (e.g., ultrasonic energy), thermal energy, or any combination thereof that is suitable to achieve the intended sterilizing effect when used in an appropriate treatment regimen to reduce the microbial load (e.g., bacterial load, fungi, protozoa, parasites, or viral load) at the target site.

[0040] As used herein, the term "energy guide" refers to any element that can carry any kind of energy (e.g., electromagnetic energy, mechanical energy, thermal energy) from one end to the other end. In one embodiment, the optical guide can be an optical fiber. Well-known optical fibers include fibers made of fused silica, pure silica, organic silicon, hollow tubes, clad and unclad fibers, and the fibers can be single or in bundles. The optical fiber can also be made of a transparent conductive material, such as SrNbO3. Other optical fibers are provided with other diluents such as water-based liquid fibers, or alcohols, ethers, aldehydes, ketones, and other liquids suitable for the transmission of the effective wavelength, and some can reduce the thermal energy with infrared energy.

[0041] As used herein, the term "energy source" refers to a source of electromagnetic radiation, mechanical energy (e.g., sound or ultrasonic), thermal energy, or any combination thereof. The energy source can include a plurality of energy sources, and the energy from the energy source can be administered directly to the target site or through an energy guide.

[0042] As used herein, the term "imaging module" represents an imaging device (imaging element) and processing circuitry used to generate a video signal. As used herein, the term "integral" refers to being part of, associated with, or belonging to the entire device, i.e., being necessary for the integrity of the whole, or consisting of, or constituting parts that make up the whole.

[0043] As used herein, the term "intense pulsed light" or "IPL" refers to non-laser light that has various wavelength ranges and is emitted periodically in the form of intense pulses. For example, intense pulsed light IPL is light in the wavelength range of about 300 to 1200 nm (varies depending on the intense pulsed light IPL device), and is emitted periodically in the form of intense pulses. An intense pulsed light IPL irradiation device controls the wavelength of the light emitted by a filter by using a lamp flash that emits light with a wavelength of about 300 to 1,200 nm. The intense pulsed light IPL energy is supplied as a series of single, double, or triple pulse sequences with a pulse duration of 2 to 25 ms and a pulse-to-pulse delay of 10 to 500 ms. The intense pulsed light IPL radiant energy density can be in the range of 5 J / cm 2 ~60 J / cm 2 and can range.

[0044] As used herein, the term "light guide" refers to an article that receives light at an input end and propagates the light to an output end or an extraction mechanism without significant loss. Generally, a light guide operates based on the principle of total internal reflection, whereby light passing through the light guide is reflected at the surface of the light guide based on the difference in refractive index between the material of the light guide and the material immediately surrounding the light guide, such as air, cladding, etc.

[0045] As used herein, the term "proximity determination element" (proximity determination device) refers to any device that can measure the distance from the device described herein to the surface of the treatment or administration site. As used herein, the term "respiratory infection" involves, for example, the invasion and / or growth and / or colonization by pathogenic microorganisms (e.g., bacteria and viruses) in one or more components of the respiratory tract, such as the lungs, larynx, trachea, bronchi, bronchioles, or alveoli.

[0046] As used herein, the term “separable” refers to a device component, module, element, or any variation thereof that can be easily connected or disconnected by engaging or disengaging a connection at a working interface.

[0047] As used herein, the term “signal generating element” refers to a component of an apparatus that can provide a detectable signal (e.g., an audible alert, a visual cue, or haptic feedback) in accordance with a measured distance, measured by, for example, a proximity determining element of the apparatus described herein.

[0048] As used herein, the terms “disinfection” and “sterilization,” or variations thereof, refer to the reduction of microbial load (e.g., pathogenic and / or non-pathogenic) on or inside living tissue or a part of the body of an object, or on or inside an inanimate object. As used herein, these terms may be used interchangeably.

[0049] As used herein, the term “Subject” refers to mammals, including humans, that require treatment for a condition or its after-effects, or are susceptible to such conditions. Subjects include dogs, cats, pigs, cattle, sheep, goats, horses, rats, mice, and humans. The term “Subject” does not exclude individuals who are normal in any respect.

[0050] As used herein, the term “sufficient distance and time” refers to the time and distance over which the (e.g., mechanical or thermal) target site (e.g., a part of the body, a surface, or an object) formed by light or other energy generated by the device is irradiated to deliver the therapeutic dose of energy. In one embodiment, this is approximately 0.01 seconds to approximately 30 minutes. In one embodiment, a shutter is used to open, close, and regulate the passage of energy from the energy source to the target site. Irradiation may be performed directly from the end of the energy source to deliver the therapeutic dose of energy directly into a body cavity or through the skin of the target, or it may be extended through an energy guide (e.g., a light guide) located at the end of the energy guide.

[0051] As used herein, the term “therapeutic dose energy” refers to the amount of appropriate electromagnetic energy, mechanical energy (e.g., ultrasonic energy), thermal energy, or a combination thereof, to achieve the intended therapeutic effect of an appropriate treatment regimen to alleviate the symptoms or severity of a disease. A dose can be considered a therapeutic dose for the treatment of cancer or metastasis if it is sufficient to produce the following effects: slowing or cessation of tumor or metastasis growth, or finding a reduction in the size of the tumor or metastasis, and / or a longer lifespan for the patient. A dose can be considered a therapeutic dose for the treatment of bacterial, fungal, protozoan, or viral infections if it is sufficient to produce the following effects: slowing or cessation of infection, and / or a longer lifespan for the patient. An appropriate therapeutic dose generally strikes a balance between therapeutic effect and acceptable toxicity, provided that the treatment is beneficial and, for example, side effects and toxicity are acceptable.

[0052] As used herein, the term “treatment” (also known as “treat” or “treating”) refers, in its broadest sense, to any administration of a therapeutic agent (e.g., ultraviolet light) that partially or completely alleviates, improves, restores, inhibits, delays the onset, reduces the severity, or decreases the incidence of one or more symptoms, features, or causes of a particular disease, disorder, or condition. In some embodiments, such treatment may be administered to subjects who show no signs of the related disease, disorder, or condition, or to subjects who show only the initial signs of the disease, disorder, or condition. Alternatively or additionally, in some embodiments, treatment may be administered to subjects who show one or more established signs of the related disease, disorder, or condition. In some embodiments, treatment may be for subjects diagnosed with the related disease, disorder, or condition. In some embodiments, treatment may be for subjects known to have one or more susceptibility factors that are statistically correlated with an increased risk of developing the related disease, disorder, or condition. [Brief explanation of the drawing]

[0053] [Figure 1] This is a schematic diagram showing the control side of the treatment device. The base components, control buttons, and interchangeable head components (indicated by asterisks) are shown. [Figure 2] This is a schematic diagram showing the treatment surface of the treatment device. The base components, UVC LED source, and replaceable head components (indicated by asterisks) are shown. [Figure 3] This is a schematic diagram showing a side view of the treatment device and charging docking station. [Figure 4] This is a schematic diagram showing the internal components of the treatment delivery device. The control buttons, control circuit, charging connector, battery, and UVCLED components are shown. [Figure 5] This is a schematic diagram showing the components of an energy transfer head. Multiple UVC LEDs are depicted, which can be connected to a module equipped with a heating element and a cover microscope. [Figure 6] It is a schematic diagram showing an energy transmission head component composed of an ultrasonic transducer and a heating element. [Figure 7] It is a schematic diagram showing a plurality of images of an energy transmission head module configured to transmit UVC light, ultrasonic waves, and heat. Part A of FIG. 7 shows the ultrasonic transducer, Part B shows the heating element, and Parts C and D show the UVC LEDs. [Figure 8] It is a schematic diagram showing an energy transmission head module configured to transmit UVC light, ultrasonic waves, and heat. [Figure 9] It is a schematic diagram showing the control side of a treatment device. The head component, control buttons, power button, and base component are shown. [Figure 10] It is a schematic diagram showing a side view of a treatment device having a base component and a head component. [Figure 11] It is a schematic diagram showing the treatment side of a treatment device. The imaging module (HD camera), UVC LED source, proximity measurement element, and base component are shown. [Figure 12] It is a schematic diagram showing the control side of a treatment device. The video screen, head module, control buttons, power button, and base component are shown. [Figure 13] It is a schematic diagram showing the control side of a treatment device. The video screen, head module, control buttons, power button, and base component are shown. [Figure 14] It is a schematic diagram showing the treatment side of a treatment device. The imaging module (HD camera), UVC LED source, proximity measurement element, and base component are shown. [Figure 15] It is a schematic diagram showing the control side of a treatment device. The signal generation element (video screen), control buttons, power button, and base component are shown. [Figure 16] It is a comprehensive schematic diagram showing the treatment side of a treatment device. The proximity measurement element and an array of UVA LEDs are shown. [Figure 17]This is a schematic diagram showing the treatment side of the treatment device. The proximity measurement element and the UVALED array are shown. [Figure 18] This is a schematic diagram of a UVC sterilization device. Multiple UVC LED sources, a base component configured to transmit ultrasound, and a contact lens well are shown. [Figure 19] This is a schematic diagram of a UVC sterilization device. Multiple UVC LED sources, a base component configured to transmit ultrasound, and a contact lens well are shown. [Figure 20] This is a schematic top view of a UVC sterilization device. Multiple UVC LED sources, a base component configured to transmit ultrasound, and a contact lens well are shown. [Figure 21] This is a schematic side view of a UVC sterilization device. The control circuit compartment and battery compartment, configured to transmit ultrasound and UVC, are shown. [Figure 22] This is a schematic diagram of the internal components of the base of a UVC sterilization device. It shows the control circuit compartment configured to transmit ultrasound and UVC, the battery compartment, and the ultrasonic transducer. [Figure 23] This is a schematic diagram of an embodiment of a vitrectomy element connected to the distal end of the head component of a UVC sterilizer. A vitreous probe and a vitreous probe opening are shown. In this embodiment, UVC radiation enters from one end of the vitrectomy element and exits from the vitreous probe opening, which is configured to be inserted into the internal region of the eye. [Figure 24A] This is a schematic side view of an embodiment of a vitreous resection element having a base with a diameter of 6 mm, a vitreous probe with a length of 12 mm, and a vitreous probe opening with a diameter of 1 mm. [Figure 24B] This is a schematic perspective view of one embodiment of a vitreous resection element having a vitreous probe opening with a diameter of 1 mm. [Figure 25] This is a schematic diagram showing an embodiment of an optical guide for transmitting UVC light to the vitreous humor of the eye. A needle may be used in conjunction with the guide to extract a portion of the vitreous humor. [Figure 26] This is a schematic diagram of an embodiment of an eye stabilizing element with a length of 10 mm from proximal to distal end. The distal end is shown as a smooth edge. The eye stabilizing element is shown in a conical shape with a larger diameter at the proximal end than at the distal end. The distal end stabilizes the eye by contacting the target eye and minimizing eye movement. The proximal end is configured to be attached to the distal end of the head component of the device. Part A of Figure 26 is a side view, and part B is a perspective view. The distal end is shown with a diameter of 6 mm, and the proximal end is shown with a diameter of 10 mm. [Figure 27A] This is a schematic diagram of one embodiment of an eye stabilization element. The distal end is shown as having a smooth edge. The eye stabilization element is shown in a conical shape with a larger diameter at the proximal end than at the distal end. The distal end stabilizes the eye by contacting the target eye and minimizing eye movement. The proximal end is configured to be attached to the distal end of the head component of the device. [Figure 27B] This is a schematic diagram of one embodiment of an eye stabilization element. The distal end is shown as having a toothed, castle-like rim. The eye stabilization element is shown in a conical shape with a larger diameter at the proximal end than at the distal end. The distal end stabilizes the eye by contacting the target eye and minimizing eye movement. The proximal end is configured to be attached to the distal end of the head component of the device. [Figure 28A] This is a schematic diagram of an embodiment of an optical guide used to deliver a therapeutic dose of UVC to the mouth of a target (for example, to treat gingivitis). This exemplary embodiment is shown to have a length of 40 mm from proximal to distal end and a diameter of 15 mm at the proximal end. The optical guide is configured to be attached to the head component of the device at the proximal end. The optical guide is configured with a UVC LED at the distal end. [Figure 28B] This is a schematic top view of an embodiment of a light guide used to deliver a therapeutic dose of UVC to the mouth of a target (for example, to treat gingivitis). A UVC LED is shown. [Figure 28C]This is a schematic side view of an embodiment of an optical guide used to deliver a therapeutic dose of UVC to the mouth of a target (e.g., to treat gingivitis). The proximal and distal ends, as well as the distal UVC LED, are shown. [Figure 28D] This is a side view of an embodiment of a light guide used to deliver a therapeutic dose of UVC to the mouth of a target (for example, to treat gingivitis). The head component, base component, UVC LED, and the light guide attached to it are shown. [Modes for carrying out the invention]

[0054] The present invention features devices, systems, and methods of use for delivering therapeutic or germicidal ultraviolet (UV) radiation. The devices and systems described herein can be used for a variety of purposes, including the treatment of ocular conditions such as blepharitis, meibomian gland disease (MGD), ocular cancer, ocular infections, and keratoconus. Using the devices described herein, germicidal or therapeutic radiation can be delivered to various tissues, such as the eyes, nasal cavity, oral cavity, skin tissue, or lumens. The devices can also be used to treat cancer (e.g., cancer of the eye or eyelid), neoplasia, and / or dysplasia. Generally, the devices comprise a base component and a head component attached thereto, the head component configured to deliver therapeutic or germicidal UV radiation (e.g., UVA or UVC) to the treatment site of the target or to the device. The devices can also be designed to be multifunctional, allowing a single device to be used with multiple interchangeable heads, each head being used according to the desired purpose or function. The components of the devices and systems are described in more detail below.

[0055] <Base Components> The base component of the apparatus described herein comprises a distal portion and a proximal portion, the proximal portion configured to connect to a head component. The base component may have any suitable size and shape so as to be appropriately configured to accommodate the head component thereon. The base component may be ergonomically designed to allow for easy control of the handheld device. For example, the base component may have a handle so as to allow users, such as healthcare providers, to easily operate the device. The base component may be configured to be mounted on another device or instrument such as a microscope, slit lamp, power supply, or energy source (e.g., UV (e.g., UVA or UVC), infrared (IR), heat, and ultrasound). The base component may have a housing, for example, on its distal portion, for mounting the head component or other accessory components. The base component may have a housing for mounting the base component to another instrument, such as a slit lamp. The base component may be designed to be detachably mounted (e.g., detachable) to the head component, and the base component and head component form a system. Alternatively, the base components can be designed to be integrated with the head components.

[0056] <Head Components> The head component of the device described in this specification comprises a distal portion and a proximal portion. The distal portion transmits a treatment energy source (e.g., UV, infrared IR, heat, microwave, intense pulsed light, and / or ultrasound) to a treatment or sterilization site. The proximal portion of the head component is configured to be attached or mounted to the base component. The head component can have any suitable geometry, for example, to transmit treatment energy to a suitable site (e.g., the eye, eyelid, nasal cavity, oral cavity, dental cavity, periodontal tissue, skin tissue, or lumen (e.g., gastrointestinal lumen, oropharyngeal lumen, genital lumen, or urinary lumen)). For example, a device configured to transmit treatment energy to the eyelid can comprise a head component having a size and shape (e.g., curvature) configured to fit the subject's eyelid or set of eyelids. In some embodiments, the head component can comprise an attachment configured to contact the treatment site. In some embodiments, the head component comprises an optical guide configured to transmit therapeutic UV radiation to a tooth, part of a tooth, a cavity, or a dental cavity (e.g., during a root canal or extraction procedure). In some embodiments, the optical guide is configured to transmit UV radiation to an area where a tooth or part thereof has been previously removed.

[0057] The head component can house a treatment energy source. For example, a treatment energy source (e.g., UV) can be integrated within or on the head. Alternatively, the head component can function as a delivery mechanism that directs the treatment energy source to the application site via an energy source. In some embodiments, the device further comprises an optical guide for transmitting UV radiation. The optical guide can be attached to the head component and transmits treatment energy from the source to the application site via the optical guide.

[0058] <UV radiation> The apparatus described herein comprises a UV radiation source. The UV radiation may be, for example, UVC radiation, UVA radiation, or a combination thereof. UVC radiation may have wavelengths from about 100 nm to about 280 nm (e.g., about 200 nm to about 280 nm, e.g., about 220 nm to about 280 nm, e.g., about 240 nm to 270 nm, e.g., about 250 nm to about 270 nm, or from about 260 nm to about 270 nm, e.g., about 254 nm, about 255 nm, or about 265 nm). UVA radiation may have wavelengths from about 315 nm to about 400 nm. The UV radiation source may be configured to emit radiation at multiple wavelengths. The radiation source is tunable to emit radiation at selected wavelengths. The UV radiation source may comprise at least one light-emitting diode (LED) or more LEDs that emit UV radiation. For example, the radiation source may comprise 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 or more LEDs that emit UV radiation. In one embodiment, the UV radiation source comprises 8 LEDs.

[0059] In some embodiments, the UV radiation source has a power output of approximately 0.005 mW to approximately 50 mW (e.g., approximately 0.005 mW to approximately 5 mW, e.g., approximately 0.01 mW to approximately 1 mW). For example, the UV radiation source has a power output of approximately 0.005 mW to approximately 0.01 mW, e.g., approximately 0.006 mW, 0.007 mW, 0.008 mW, 0.009 mW, or 0.01 mW, e.g., approximately 0.01 mW to approximately 0.01 mW, 0.1 mW, e.g., approximately 0.02 mW, 0.03 mW, 0.04 mW, 0.05 mW, 0.06 mW, 0.07 mW, 0.08 mW, 0.09 mW, or 0.1 mW, e.g., approximately 0.1 mW to approximately 1 mW, e.g., approximately 0 It can have power outputs of 0.2mW, 0.3mW, 0.4mW, 0.5mW, 0.6mW, 0.7mW, 0.8mW, 0.9mW, or 1mW, for example, about 1mW to about 10mW, for example, about 2mW, 3W, 4mW, 5mW, 6mW, 7mW, 8mW, 9mW, or 10mW, for example, about 10mW to about 50mW, for example, about 15mW, 20mW, 25mW, 30mW, 35mW, 40mW, 45mW, or 50mW. The power of the radiation source is adjustable to emit the desired power output.

[0060] The UV radiation source can be configured to irradiate the entire surface of the eye. The UV radiation source can be configured to irradiate a zone of tissue having a maximum dimension of less than approximately 10 cm, for example, approximately 9 cm, 8 cm, 7 cm, 6 cm, 5 cm, 4 cm, 3 cm, 2 cm, 1 cm, 0.9 cm, 0.8 cm, 0.7 cm, 0.6 cm, 0.5 cm, 0.4 cm, 0.3 cm, 0.2 cm, or less than 0.1 cm. The radiation source can be configured to irradiate a substantially circular zone of tissue, an elongated zone of tissue, or an annular zone of body tissue. In some embodiments, the radiation source is configured to be adjustable to adjust the size and / or shape of the irradiated zone. The device can be configured to scan UV radiation across a zone of body tissue. This can be achieved, for example, by moving a base component or a handle on it, or by rotating or moving a component within a head component.

[0061] In some embodiments, the UV radiation source is approximately 0.01 mW / cm². 2 ~about 500mW / cm 2 For example, approximately 0.01 mW / cm² 2 ~about 50mW / cm 2 For example, approximately 0.01 mW / cm² 2 ~about 5mW / cm 2 It generates a radiation intensity of approximately 0.01 mW / cm². For example, a UV radiation source produces approximately 0.01 mW / cm². 2 ~about 0.1mW / cm 2 For example, approximately 0.02 mW / cm² 2 , 0.03 mW / cm 2 , 0.04 mW / cm² 2 , 0.05 mW / cm 2 , 0.06 mW / cm 2 , 0.07 mW / cm 2 , 0.08 mW / cm 2 , 0.09 mW / cm² 2 , 0.1 mW / cm 2 For example, approximately 0.1 mW / cm² 2 ~about 1mW / cm 2 For example, approximately 0.2 mW / cm² 2 , 0.3 mW / cm 2 , 0.4 mW / cm 2 , 0.5 mW / cm 2 , 0.6 mW / cm 2 , 0.7 mW / cm 2 , 0.8 mW / cm 2 0.9 mW / cm² 2 , or 1 mW / cm 2 For example, from approximately 1 mW / cm² 2 ~about 10mW / cm 2 For example, approximately 2 mW / cm² 2 3mW / cm 2 4 mW / cm² 2 5 mW / cm² 2 , 6mW / cm 2 7mW / cm 2 8mW / cm 2 9 mW / cm² 2 , 10 mW / cm 2 For example, approximately 10 mW / cm² 2 ~about 100mW / cm 2For example, approximately 20 mW / cm² 2 30 mW / cm² 2 40 mW / cm² 2 50mW / cm 2 60mW / cm² 2 70mW / cm² 2 80mW / cm² 2 90 mW / cm² 2 , or 100mW / cm² 2 For example, approximately 100 mW / cm² 2 ~about 500mW / cm 2 For example, approximately 150 mW / cm² 2 , 200mW / cm 2 , 250mW / cm 2 , 300mW / cm 2 350mW / cm² 2 , 400mW / cm 2 , 450mW / cm 2 , or 500mW / cm² 2 It can generate the radiation intensity.

[0062] The UV radiation source can be administered over a certain period of time. The dose can be administered as a continuous dose or as pulses. The dose can be, for example, from about 0.01 second to about 600 seconds, for example, from about 0.01 second to about 0.1 second, for example, about 0.02 seconds, 0.03 seconds, 0.04 seconds, 0.05 seconds, 0.06 seconds, 0.07 seconds, 0.08 seconds, 0.09 seconds, or 0.1 second, for example, from about 0.1 second to about 1 second, for example, about 0.2 seconds, 0.3 seconds, 0.4 seconds, 0.5 seconds, 0.6 seconds, 0.7 seconds, 0.8 seconds, 0.9 seconds, or 1 second, for example, from about 1 second to about 10 seconds, for example, about 2 seconds, 3 seconds, 4 seconds, 5 seconds, 6 seconds, 7 seconds, 8 seconds, 9 seconds, or 10 seconds, for example, from about 10 seconds to about 100 seconds, for example, about 20 seconds, 30 seconds, 40 seconds, 50 seconds, 60 seconds, 70 seconds, 80 seconds, 90 seconds, or 100 seconds, for example, from about 100 seconds to about 600 seconds, for example, about 110 seconds, 120 seconds, 150 seconds, 180 seconds, 240 seconds, 270 seconds, 300 seconds, 330 seconds, 360 seconds, 390 seconds, 420 seconds, 450 seconds, 480 seconds, 510 seconds, 540 seconds, 570 seconds, or 600 seconds. The pulsed dose of radiation can have, for example, a ratio of on-time to off-time from about 0.01 to about 100, for example, from about 0.01 to about 0.1, for example, about 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, or 0.1, for example, from about 0.1 to about 1, for example, about 0.2, 0.3, 0, 0.5, 0.6, 0.7, 0.8, 0.9, or 1, for example, from about 1 to about 10, for example, about 2, 3, 4, 5, 6, 7, 8, 9, or 10, for example, from about 10 to about 100, for example, about 20, 30, 40, 50, 60, 70, 80, 90, or 100. The pulsed dose of radiation can have a pulse shape or waveform selected from the group consisting of a square, triangle, sine wave, sawtooth wave, and their superpositions or combinations.

[0063] The UV radiation source is about 0.01 mJ / cm 2 ~ about 500 mJ / cm 2 For example, about 0.01 mJ / cm 2 ~ about 250 mJ / cm 2 For example, about 0.01 mJ / cm 2 ~ about 15 mJ / cm 2 For example, about 1 mJ / cm 2~about 15 mJ / cm 2 can be administered at a dose of. For example, the radiation source is about 0.01 mJ / cm 2 ~about 0.1 mJ / cm 2 , for example, about 0.02 mJ / cm 2 , 0.03 mJ / cm 2 , 0.04 mJ / cm 2 , 0.05 mJ / cm 2 , 0.06 mJ / cm 2 , 0.07 mJ / cm 2 , 0.08 mJ / cm 2 , 0.09 mJ / cm 2 , or 0.1 mJ / cm 2 , for example, about 0.1 mJ / cm 2 ~about 1 mJ / cm 2 , for example, about 0.2 mJ / cm[[ID=,29]] 2 , 0.3 mJ / cm 2 , 0.4 mJ / cm 2 , 0.5 mJ / cm 2 , 0.6 mJ / cm 2 , 0.7 mJ / cm 2 , 0.8 mJ / cm 2 , 0.9 mJ / cm 2 , or 1 mJ / cm 2 , for example, about 1 mJ / cm 2 ~about 10 mJ / cm 2 , for example, about 2 mJ / cm 2 , 3 mJ / cm 2 , 4 mJ / cm 2 , 5 mJ / cm 2 , 6 mJ / cm 2 , 7 mJ / cm 2 , 8 mJ / cm 2 , 9 mJ / cm 2 , or 10 mJ / cm 2 , for example, about 10 mJ / cm 2 ~about 100 mJ / cm 2 , for example, about 20 mJ / cm 2 , 30 mJ / cm 2 , 40 mJ / cm 2 , 50 mJ / cm 2 , 60 mJ / cm 2 , 70 mJ / cm 2 , 80 mJ / cm 290 mJ / cm² 2 , or 100 mJ / cm 2 For example, approximately 100 mJ / cm² 2 ~about 250mJ / cm 2 For example, approximately 125 mJ / cm² 2 , 150 mJ / cm 2 , 175 mJ / cm 2 , 200 mJ / cm 2 , 225 mJ / cm 2 , or 250 mJ / cm² 2 It can be administered at a dose of [number]. In some embodiments, the UV radiation source includes an adaptive optical component configured to adjust the focus of the UV radiation.

[0064] <Infrared IR radiation> The apparatus described herein may be equipped with an infrared (IR) radiation source. Infrared (IR) radiation ranges from approximately 750 nm to approximately 1,000,000 nm (for example, approximately 800 nm to approximately 900,000 nm, approximately 810 nm to approximately 500,000 nm, approximately 820 nm to approximately 250,000 nm, approximately 830 nm to approximately 100,000 nm, approximately 850 nm to approximately 50,000 nm, approximately 860 nm to approximately 25,000 nm, approximately 870 nm to approximately 10,000 nm, approximately 880 nm to approximately 9,000 nm, approximately 890 nm to approximately 8,000 nm, approximately 90 The infrared (IR) radiation source can have wavelengths of approximately 0 nm to 7,000 nm, approximately 910 nm to 6,000 nm, approximately 920 nm to 5,000 nm, approximately 930 nm to 4,000 nm, approximately 940 nm to 3,000 nm, approximately 950 nm to 2,500 nm, approximately 960 nm to 2,400 nm, approximately 970 nm to 2,300 nm, approximately 980 nm to 2,200 nm, approximately 990 nm to 2,100 nm, or approximately 1,000 nm to 2,000 nm. The infrared (IR) radiation source can be configured to emit radiation at multiple wavelengths. The radiation source is tunable to emit radiation at selected wavelengths. The infrared (IR) radiation source may comprise at least one light-emitting diode (LED) or multiple LEDs that emit infrared (IR) radiation. For example, the radiation source may have 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 or more LEDs that emit infrared (IR) radiation.

[0065] In some embodiments, the infrared (IR) radiation source has a power output of approximately 0.005 mW to approximately 50 mW (e.g., approximately 0.005 mW to approximately 5 mW, e.g., approximately 0.01 mW to approximately 1 mW). For example, the infrared (IR) radiation source has a power output of approximately 0.005 mW to approximately 0.01 mW, e.g., approximately 0.006 mW, 0.007 mW, 0.008 mW, 0.009 mW, or 0.01 mW, e.g., approximately 0.01 mW to approximately 0.01 mW, 0.1 mW, e.g., approximately 0.02 mW, 0.03 mW, 0.04 mW, 0.05 mW, 0.06 mW, 0.07 mW, 0.08 mW, 0.09 mW, or 0.1 mW, e.g., approximately 0.1 mW to approximately 1 mW, e.g., approximately It can have power outputs of 0.2mW, 0.3mW, 0.4mW, 0.5mW, 0.6mW, 0.7mW, 0.8mW, 0.9mW, or 1mW, for example, about 1mW to about 10mW, for example, about 2mW, 3W, 4mW, 5mW, 6mW, 7mW, 8mW, 9mW, or 10mW, for example, about 10mW to about 50mW, for example, about 15mW, 20mW, 25mW, 30mW, 35mW, 40mW, 45mW, or 50mW. The power of the radiation source is adjustable to emit the desired power output.

[0066] An infrared (IR) radiation source can be configured to irradiate a zone of tissue having a maximum dimension of less than approximately 10 cm (e.g., approximately 90 mm, 80 mm, 70 mm, 60 mm, 50 mm, 40 mm, 30 mm, 20 mm, or 10 mm, e.g., less than approximately 9 mm, 8 mm, 7 mm, 6 mm, 5 mm, 4 mm, 3 mm, 2 mm, or 1 mm). The radiation source can be configured to irradiate a substantially circular zone of tissue, an elongated zone of tissue, or an annular zone of body tissue. In some embodiments, the radiation source is configured to be adjustable to adjust the size and / or shape of the zone being irradiated. The device can be configured to scan infrared (IR) radiation across a zone of body tissue. This can be achieved, for example, by moving a base component or a handle on it, or by rotating or moving a component within a head component.

[0067] In some embodiments, the infrared (IR) radiation source is approximately 0.01 mW / cm². 2 ~about 500mW / cm 2 For example, approximately 0.01 mW / cm² 2 ~about 50mW / cm 2 For example, approximately 0.01 mW / cm² 2 ~about 5mW / cm 2 It generates a radiation intensity of approximately 0.01 mW / cm². For example, an infrared (IR) radiation source produces approximately 0.01 mW / cm². 2 ~about 0.1mW / cm 2 For example, approximately 0.02 mW / cm² 2 , 0.03 mW / cm 2 , 0.04 mW / cm² 2 , 0.05 mW / cm 2 , 0.06 mW / cm 2 , 0.07 mW / cm 2 , 0.08 mW / cm 2 , 0.09 mW / cm² 2 , 0.1 mW / cm 2 For example, approximately 0.1 mW / cm² 2 ~about 1mW / cm 2 For example, approximately 0.2 mW / cm² 2 , 0.3 mW / cm 2 , 0.4 mW / cm 2 , 0.5 mW / cm 2 , 0.6 mW / cm 2 , 0.7 mW / cm 2 , 0.8 mW / cm 2 0.9 mW / cm² 2 , or 1 mW / cm 2 For example, approximately 1 mW / cm² 2 ~about 10mW / cm 2 For example, approximately 2 mW / cm² 2 3mW / cm 2 4 mW / cm² 2 5 mW / cm² 2 , 6mW / cm 2 7mW / cm 2 8mW / cm 2 9 mW / cm² 2 , 10 mW / cm 2 For example, approximately 10 mW / cm² 2 ~about 100mW / cm 2For example, approximately 20 mW / cm² 2 30 mW / cm² 2 40 mW / cm² 2 50mW / cm 2 60mW / cm² 2 70mW / cm² 2 80mW / cm² 2 90 mW / cm² 2 , or 100mW / cm² 2 For example, approximately 100 mW / cm² 2 ~about 500mW / cm 2 For example, approximately 150 mW / cm² 2 , 200mW / cm 2 , 250mW / cm 2 , 300mW / cm 2 350mW / cm² 2 , 400mW / cm 2 , 450mW / cm 2 , or 500mW / cm² 2 It can generate the radiation intensity.

[0068] Infrared (IR) radiation sources can be administered over a period of time. The dose can be administered as a continuous dose or as pulses. For example, doses can range from approximately 0.01 seconds to approximately 600 seconds, for example, approximately 0.01 seconds to approximately 0.1 seconds, for example, approximately 0.02 seconds, 0.03 seconds, 0.04 seconds, 0.05 seconds, 0.06 seconds, 0.07 seconds, 0.08 seconds, 0.09 seconds, or 0.1 seconds, for example, approximately 0.1 seconds to approximately 1 second, for example, approximately 0.2 seconds, 0.3 seconds, 0.4 seconds, 0.5 seconds, 0.6 seconds, 0.7 seconds, 0.8 seconds, 0.9 seconds, or 1 second, for example, approximately 1 second to approximately 10 seconds, for example, approximately 2 seconds, 3 seconds, 4 seconds, 5 seconds, 6 seconds. It can be administered for 7 seconds, 8 seconds, 9 seconds, or 10 seconds, for example, about 10 seconds to about 100 seconds, for example, about 20 seconds, 30 seconds, 40 seconds, 50 seconds, 60 seconds, 70 seconds, 80 seconds, 90 seconds, or 100 seconds, for example, about 100 seconds to about 600 seconds, for example, about 110 seconds, 120 seconds, 150 seconds, 180 seconds, 240 seconds, 270 seconds, 300 seconds, 330 seconds, 360 seconds, 390 seconds, 420 seconds, 450 seconds, 480 seconds, 510 seconds, 540 seconds, 570 seconds, or 600 seconds. The pulsed dose of radiation may have on-time to off-time ratios of, for example, about 0.01 to about 100, for example, about 0.01 to about 0.1, for example, about 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, or 0.1, for example, about 0.1 to about 1, for example, about 0.2, 0.3, 0, 0.5, 0.6, 0.7, 0.8, 0.9, or 1, for example, about 1 to about 10, for example, about 2, 3, 4, 5, 6, 7, 8, 9, or 10, for example, about 10 to about 100, for example, about 20, 30, 40, 50, 60, 70, 80, 90, or 100.

[0069] The infrared (IR) radiation source emits approximately 0.01 mJ / cm². 2 ~about 500mJ / cm 2 For example, approximately 0.01 mJ / cm² 2 ~about 250mJ / cm 2 For example, approximately 0.01 mJ / cm² 2 ~Approx. 15mJ / cm 2 For example, about 1 mJ / cm² 2 ~Approx. 15mJ / cm 2 It can be administered at a dose of approximately 0.01 mJ / cm². For example, the radiation source is approximately 0.01 mJ / cm². 2~about 0.1mJ / cm 2 For example, approximately 0.02 mJ / cm² 2 , 0.03 mJ / cm 2 , 0.04 mJ / cm 2 , 0.05 mJ / cm 2 , 0.06 mJ / cm 2 , 0.07 mJ / cm 2 , 0.08 mJ / cm 2 , 0.09 mJ / cm 2 , or 0.1 mJ / cm 2 For example, approximately 0.1 mJ / cm² 2 ~Approx. 1mJ / cm 2 For example, approximately 0.2 mJ / cm² 2 , 0.3 mJ / cm 2 , 0.4 mJ / cm 2 , 0.5 mJ / cm 2 , 0.6 mJ / cm 2 , 0.7 mJ / cm 2 , 0.8 mJ / cm 2 , 0.9 mJ / cm 2 , or 1 mJ / cm 2 For example, approximately 1 mJ / cm² 2 ~about 10mJ / cm 2 For example, approximately 2 mJ / cm² 2 3 mJ / cm 2 4 mJ / cm 2 5 mJ / cm 2 6 mJ / cm 2 7 mJ / cm 2 8 mJ / cm 2 9 mJ / cm² 2 , or 10 mJ / cm 2 For example, approximately 10 mJ / cm² 2 ~about 100mJ / cm 2 For example, approximately 20 mJ / cm² 2 30 mJ / cm² 2 40 mJ / cm² 2 50 mJ / cm² 2 60 mJ / cm² 2 70 mJ / cm² 2 80 mJ / cm² 2 90 mJ / cm² 2 , or 100 mJ / cm 2 For example, approximately 100 mJ / cm² 2~about 250mJ / cm 2 For example, approximately 125 mJ / cm² 2 , 150 mJ / cm 2 , 175 mJ / cm 2 , 200 mJ / cm 2 , 225 mJ / cm 2 , or 250 mJ / cm² 2 It can be administered at this dose.

[0070] <Powerful pulsed light> The described apparatus may include a powerful pulsed light source (IPL). A powerful pulsed light IPL source includes a non-laser light source that emits light of various wavelengths and generates bursts of light in the form of powerful pulses. A powerful pulsed light IPL source can generate light with wavelengths ranging from approximately 300 nm to approximately 1,200 nm (e.g., approximately 400 nm to approximately 1,100 nm, approximately 500 nm to approximately 1,000 nm, approximately 600 nm to approximately 900 nm, or approximately 700 nm to approximately 800 nm). The wavelengths emitted by a powerful pulsed light IPL vary depending on the powerful pulsed light IPL apparatus. In some embodiments, the powerful pulsed light IPL source generates bursts of light with broadband wavelengths, and the light is filtered to control the wavelength range that can exit the powerful pulsed light IPL source. In some examples, the filter is an optical filter configured as a low-pass filter, a high-pass filter, or a band-pass filter. In some embodiments, the filter may be configured to have notches that allow light of a small bandwidth (e.g., light of wavelengths differing by only less than 500 nm, 400 nm, 300 nm, 200 nm, 100 nm, 50 nm, 25 nm, 20 nm, 10 nm, 5 nm, or less than 2 nm) to pass through the filter.The powerful pulsed IPL energy has a pulse duration of approximately 2ms to 25ms (for example, approximately 2ms, 3ms, 4ms, 5ms, 6ms, 7ms, 8ms, 9ms, 10ms, 11ms, 12ms, 13ms, 14ms, 15ms, 16ms, 17ms, 18ms, 19ms, 20ms, 21ms, 22ms, 23ms, 24ms, or 25ms), and an inter-pulse delay of approximately 10ms to 500ms (for example, approximately 10ms, 20ms, 30ms, 40ms, 50ms, 60ms, 70ms, 80ms, 90ms, 100ms, 110ms, 120ms, 130ms, 140ms) and an inter-pulse delay of approximately 10ms to 500ms (for example, approximately 10ms, 20ms, 30ms, 40ms, 50ms, 60ms, 70ms, 80ms, 90ms, 100ms, 110ms, 120ms, 130ms, 140ms) It can be transmitted as a series of single, duplex, or triple pulse sequences of approximately msms, 150ms, 160ms, 170ms, 180ms, 190ms, 200ms, 210ms, 220ms, 230ms, 240ms, 250ms, 260ms, 270ms, 280ms, 290ms, 300ms, 310ms, 320ms, 330ms, 340ms, 350ms, 360ms, 370ms, 380ms, 390ms, 400ms, 410ms, 420ms, 430ms, 440ms, 450ms, 460ms, 470ms, 480ms, 490ms, or 500ms. The high-intensity pulsed light IPL radiation energy density is approximately 5 J / cm. 2 ~60J / cm 2 (For example, approximately 5 J / cm 2 , about 6J / cm 2 , about 7J / cm 2 , about 8J / cm 2 , about 9J / cm 2 , about 10J / cm 2 , about 11J / cm 2 , about 12J / cm 2 , about 13J / cm 2 , about 14J / cm 2 , about 15J / cm 2 , about 16J / cm 2 , about 17J / cm 2 , about 18J / cm 2 , about 19J / cm 2 , about 20J / cm 2 , about 21J / cm 2, about 22 J / cm 2 , about 23 J / cm 2 , about 24 J / cm 2 , about 25 J / cm 2 , about 26 J / cm 2 , about 27 J / cm 2 , about 28 J / cm 2 , about 29 J / cm 2 , about 30 J / cm 2 , about 31 J / cm 2 , about 32 J / cm 2 , about 33 J / cm 2 , about 34 J / cm 2 , about 35 J / cm 2 , about 36 J / cm 2 , about 37 J / cm 2 , about 38 J / cm 2 , about 39 J / cm 2 , about 40 J / cm 2 , about 41 J / cm 2 , about 42 J / cm 2 , about 43 J / cm 2 , about 44 J / cm 2 , about 45 J / cm 2 , about 46 J / cm 2 , about 47 J / cm 2 , about 48 J / cm 2 , about 49 J / cm 2 , about 50 J / cm 2 , about 51 J / cm 2 , about 52 J / cm 2 , about 53 J / cm 2 , about 54 J / cm 2 , about 55 J / cm 2 , about 56 J / cm 2 , about 57 J / cm 2 , about 58 J / cm 2 , about 59 J / cm 2 , or about 60 J / cm 2 ) may have a range of.

[0071] <Ultrasonic> The apparatus described herein may include an ultrasonic source, such as an ultrasonic transducer, which may have a frequency of about 20 Hz to about 20 MHz. The ultrasonic transducer may be configured to emit ultrasonic waves at multiple frequencies. The ultrasonic source is adjustable to emit ultrasonic waves at selected frequencies. The ultrasonic source may include at least one or more transducers that emit ultrasonic waves. For example, the ultrasonic source may include 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more transducers that emit ultrasonic waves.

[0072] In some embodiments, the ultrasonic source has a frequency of about 20 Hz to about 20 MHz, for example, about 20 Hz to about 100 kHz, for example, about 20 kHz to about 100 kHz, about 20 kHz to about 80 kHz, or about 40 kHz to about 80 kHz, for example, about 20 kHz or about 40 kHz. For example, ultrasonic sources can range from approximately 20Hz to approximately 100Hz, for example, 30Hz, 30Hz, 40Hz, 50Hz, 60Hz, 70Hz, 80Hz, 90Hz, or 100Hz; for example, approximately 100Hz to approximately 1kHz, for example, approximately 200Hz, 300Hz, 400Hz, 500Hz, 600Hz, 700Hz, 800Hz, 900Hz, or 1kHz; for example, approximately 1kHz to approximately 10kHz, for example, approximately 2kHz, 3kHz, 4kHz, 5kHz, 6kHz, 7kHz, 8kHz, 9kHz, or 10kHz; for example, approximately 10kHz to approximately 100kHz, for example, approximately 20kHz, 30kHz, 40kHz, 50kHz The frequencies can be 60kHz, 70kHz, 80kHz, 90kHz, or 100kHz, for example, about 100kHz to about 1MHz, for example, about 200kHz, 300kHz, 400kHz, 500kHz, 600kHz, 700kHz, 800kHz, 900kHz, or 1MHz, for example, about 1MHz to about 20MHz, for example, about 2MHz, 3MHz, 4MHz, 5MHz, 6MHz, 7MHz, 8MHz, 9MHz, 10MHz, 11MHz, 12MHz, 13MHz, 14MHz, 15MHz, 16MHz, 17MHz, 18MHz, 19MHz, or 20MHz.

[0073] In some embodiments, a low-frequency range of ultrasound, e.g., 20 kHz to about 100 kHz, is provided. In some embodiments, the frequency range of the supplied ultrasound is about 40 kHz. In other configurations, the frequency range of the supplied ultrasound is about 20 kHz. The low-frequency ultrasound range (below 100 kHz) described herein is unique and differs from other ranges of ultrasound in its effect on cellular stimulation and increased cell membrane permeability (e.g., cavitation). In particular, it is understood that ultrasound frequencies below 100 kHz can advantageously exhibit positional properties that are independent of thermal effects, such as cavitation, microcavitation, microjet formation, and acoustic streaming effects on treated cells. These effects are useful, for example, in breaking down clogged or solidified lipid disorders in parts of the eye, such as the meibomian glands.

[0074] In some embodiments, the ultrasonic transducer is mounted on a stainless steel plate, for example, bent at 90° at its ends, to form a contact footplate. The contact footplate can be configured to contact, for example, the eyelid of the target. The footplate can independently have a length and width of about 10 mm to about 100 mm, for example, about 15 mm, 20 mm, 25 mm, 30 mm, 35 mm, 40 mm, 45 mm, 50 mm, 55 mm, 60 mm, 65 mm, 70 mm, 75 mm, 80 mm, 85 mm, or 100 mm. In some embodiments, the contact footplate is about 45 mm wide and about 20 mm high.

[0075] <Fever> The apparatus described herein may include a heat source, such as infrared (IR) or a resistive wire. The heating element (heating component) may have a thermal output of about 10 J to about 10,000 J. The heat source may be configured to emit heat from a plurality of individual elements. For example, the heat source may include 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 or more heat elements that emit heat. In some embodiments, the heating element may consist of light-emitting diodes (LEDs).

[0076] In some embodiments, heating is performed in the range of approximately 1500nm to approximately 2,000,000nm, for example, approximately 2000nm to approximately 1,000,000nm, approximately 10,000nm to approximately 500,000nm, approximately 20,000nm to approximately 100,000nm, approximately 50,000nm to approximately 100,000nm, approximately 1,000,000nm to approximately 2,000,000nm, 1,100,000nm to approximately 1,900,000nm, 1,200,000nm to approximately 1,800,000nm, and approximately 1,800,000nm. This can be done by using radiation wavelengths of approximately 1,800,000 nm, 1,400,000 nm to 1,700,000 nm, approximately 1,500,000 nm to 1,600,000 nm, approximately 1,100,000 nm, approximately 1,200,000 nm, approximately 1,300,000 nm, approximately 1,400,000 nm, approximately 1,500,000 nm, approximately 1,600,000 nm, approximately 1,700,000 nm, approximately 1,800,000 nm, approximately 1,900,000 nm, or 2,000,000 nm.

[0077] The heat source can be administered over a period of time. The dose can be administered as a continuous dose or as a pulse. The dose can be, for example, approximately 0.01 seconds to approximately 600 seconds, for example, approximately 0.01 seconds to approximately 0.1 seconds, for example, approximately 0.02 seconds, 0.03 seconds, 0.04 seconds, 0.05 seconds, 0.06 seconds, 0.07 seconds, 0.08 seconds, 0.09 seconds, or 0.1 seconds, for example, approximately 0.1 seconds to approximately 1 second, for example, approximately 0.2 seconds, 0.3 seconds, 0.4 seconds, 0.5 seconds, 0.6 seconds, 0.7 seconds, 0.8 seconds, 0.9 seconds, or 1 second, for example, approximately 1 second to approximately 10 seconds, for example, approximately 2 seconds, 3 seconds, 4 seconds, 5 seconds, 6 seconds. It can be administered for 7 seconds, 8 seconds, 9 seconds, or 10 seconds, for example, about 10 seconds to about 100 seconds, for example, about 20 seconds, 30 seconds, 40 seconds, 50 seconds, 60 seconds, 70 seconds, 80 seconds, 90 seconds, or 100 seconds, for example, about 100 seconds to about 600 seconds, for example, about 110 seconds, 120 seconds, 150 seconds, 180 seconds, 240 seconds, 270 seconds, 300 seconds, 330 seconds, 360 seconds, 390 seconds, 420 seconds, 450 seconds, 480 seconds, 510 seconds, 540 seconds, 570 seconds, or 600 seconds. The pulsed dose of radiation may have on-time to off-time ratios of, for example, about 0.01 to about 100, for example, about 0.01 to about 0.1, for example, about 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, or 0.1, for example, about 0.1 to about 1, for example, about 0.2, 0.3, 0, 0.5, 0.6, 0.7, 0.8, 0.9, or 1, for example, about 1 to about 10, for example, about 2, 3, 4, 5, 6, 7, 8, 9, or 10, for example, about 10 to about 100, for example, about 20, 30, 40, 50, 60, 70, 80, 90, or 100.

[0078] In some embodiments, the heat source can be configured to be electrically connected to a thermistor sensor for feedback control of the heating element. In some embodiments, a control loop feedback mechanism, such as a proportional-integral-derivative (PID) controller, can be connected to the thermistor sensor to continuously monitor the heating element output for the safety of the user and / or the recipient of the heat. The heat source can be configured to provide a constant temperature (e.g., about 30°C to about 50°C, e.g., about 31°C, 32°C, 33°C, 34°C, 35°C, 36°C, 37°C, 38°C, 39°C, 40°C, 41°C, 42°C, 43°C, 44°C, 45°C, 46°C, 47°C, 48°C, 49°C, or 50°C). Other heat sources are known in the art. The heat source can be placed on a head component configured to contact, for example, the eyelid or tissue area of ​​the target.

[0079] <Microwave radiation> The apparatus described herein may include a microwave source, such as a microwave transducer. The microwaves may have frequencies ranging from about 300 MHz to about 300 GHz (e.g., about 400 MHz, about 500 MHz, about 600 MHz, about 700 MHz, about 800 MHz, about 900 MHz, about 1 GHz, about 2 GHz, about 3 GHz, about 4 GHz, about 5 GHz, about 6 GHz, about 7 GHz, about 8 GHz, about 9 GHz, about 10 GHz, about 20 GHz, about 50 GHz, about 100 GHz, about 200 GHz, about 300 GHz). The microwave transducer may be configured to emit microwave radiation at multiple frequencies. The microwave source is adjustable to emit microwaves at selected frequencies. The microwave source may include at least one or more transducers that emit microwave radiation. For example, the microwave source may include 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more transducers that emit microwave radiation.

[0080] In some embodiments, the microwave source has a range of approximately 1 mm to 1,000 mm, for example, approximately 2 mm to 900 mm, approximately 5 mm to 800 mm, approximately 10 mm to 700 mm, approximately 20 mm to 600 mm, approximately 50 mm to 500 mm, approximately 100 mm to 400 mm, approximately 200 mm to 300 mm, approximately 10 mm, approximately 20 mm, approximately 30 mm, approximately 40 mm, approximately 50 mm, approximately 60 mm, approximately 70 mm, approximately 80 mm, approximately 90 mm, approximately 100 mm, approximately 110 mm, approximately 120 mm, approximately 130 mm, and approximately 140 mm. m, approximately 150mm, approximately 160mm, approximately 170mm, approximately 180mm, approximately 190mm, approximately 200mm, approximately 200mm, approximately 210mm, approximately 220mm, approximately 230mm, approximately 240mm, approximately 250mm, approximately 260mm, approximately 270mm, approximately 280mm, approximately 2 90mmmm, approximately 300mm, approximately 310mm, approximately 320mm, approximately 330mm, approximately 340mm, approximately 350mm, approximately 360mm, approximately 370mm, approximately 380mm, approximately 390mm, approximately 400mm, approximately 410mm, approximately 420mm, approximately 430mm, approximately 440 mm, approximately 450mm, approximately 460mm, approximately 470mmmm, approximately 480mm, approximately 490mm, approximately 500mm, approximately 510mm, approximately 520mm, approximately 530mm, approximately 540mm, approximately 550mm, approximately 560mm, approximately 570mm, approximately 580mm, approximately 590m m, approximately 600mm, approximately 610mm, approximately 620mm, approximately 630mm, approximately 640mm, approximately 650mm, approximately 660mm, approximately 670mm, approximately 680mm, approximately 690mm, approximately 700mm, approximately 710mm, approximately 720mmmm, approximately 730mm, approximately 740mm, It can be configured to emit microwave radiation with wavelengths of approximately 750 mm, 760 mm, 770 mm, 780 mm, 790 mm, 800 mm, 810 mm, 820 mm, 830 mm, 840 mm, 850 mm, 860 mm, 870 mm, 880 mm, 890 mm, 900 mm, 910 mm, 920 mm, 930 mm, 940 mm, 950 mm, 960 mm, 970 mm, 980 mm, 990 mm, or 1,000 mm.

[0081] <Optical Guide> In some embodiments, the apparatus described herein includes an optical guide for transmitting therapeutic (e.g., UVC) radiation. An optical guide is a device used to distribute light (such as UV) from a light source to a specific area. An optical guide can be made of a transparent material (e.g., glass or plastic) that has a material that transmits UVC radiation. An optical guide may contain a thin filament inside that can transmit optical signals by internal reflection. An optical guide can be attached to a head component and transmit UV energy from the UV source to the application site via the optical guide. An optical guide may be, for example, a waveguide, optical fiber, liquid optical guide, or hollow tube (Figures 28A-28D). An optical guide may be configured to be mated to a light source. An optical guide has, for example, an inlet end connected to a UV source and an outlet end (Figures 28A-28D) configured to transmit light to a desired area such as the eye, nasal cavity, oral cavity, skin tissue, or lumen of a target tube.

[0082] The optical guide can have any suitable width and / or length, as long as it can effectively deliver UV light to the administration site. For example, the optical guide can have lengths of, for example, about 1 mm to about 1 m, for example, about 1 mm to about 10 mm, for example, about 2 mm, 3 mm, 4 mm, 5 mm, 6 mm, 7 mm, 8 mm, 9 mm, or 10 mm, for example, about 10 mm to about 100 mm, for example, about 20 mm, 30 mm, 40 mm, 50 mm, 60 mm, 70 mm, 80 mm, 90 mm, or 100 mm, for example, about 100 mm to about 1 m, for example, about 200 mm, 300 mm, 400 mm, 500 mm, 600 mm, 700 mm, 800 mm, 900 mm, or 1 m.

[0083] The thickness (e.g., diameter) of the optical guide or the filament located inside it can be, for example, approximately 1mm to 50mm, approximately 2mm to 25mm, approximately 4mm to 15mm, or approximately 1mm, 2mm, 3mm, 4mm, 5mm, 6mm, 7mm, 8mm, 9mm, 10mm, 11mm, 12mm, 13mm, 14mm, 15mm, 16mm, 17mm, 18mm, 19mm, or 20mm. m2It could be 5mm, 30mm, 35mm, 40mm, 45mm, or 50mm.

[0084] An optical guide may be a fiber optical guide or comprise a fiber optical guide, where a fiber optical guide refers to any fiber capable of carrying any type of UV light from one end to the other. In one embodiment, the fiber optical guide carries light in the range of approximately 180 nm to 465 nm. Well-known optical fibers comprise fibers made of fused silica, pure silica, organosilicon, hollow tubes, clad and unclad fibers, and these fibers may be singular or bundled. Other optical fibers comprise liquid fibers that are water-based or of other diluents such as alcohols, ethers, aldehydes, ketones, and other liquids suitable for transmitting effective wavelengths, some of which can reduce thermal energy while carrying infrared energy.

[0085] <Vitreous excision elements> The apparatus and method of the present invention may comprise a vitrectomy element (e.g., a vitrectomy port, a vitreous probe, or a trocar) (Figures 23, 24A, 24B, and 25). The vitrectomy element is or comprises a hollow tube having one or more sharp edges at its distal end to puncture and penetrate the sclera of the eye, and is configured to deliver radiation of a therapeutic dose to an internal region of the eye (e.g., anterior region, posterior region, vitreous region, retinal region, choroidal region, macular region, intraocular lens region, ciliary muscle region, or optic nerve region). In some embodiments, the vitrectomy element is configured as a high-frequency cutting device (e.g., a vitrectomy machine) configured to cut the vitreous humor. In some embodiments, a needle may be inserted into the vitreous region of the eye through an opening created by the vitrectomy element (Figure 25). In some embodiments, the vitrectomy element is configured to allow an optical guide to pass through the internal region of the eye within the vitrectomy element. In some embodiments, the vitrectomy element is configured to be attached to an ocular stabilizing element. In some embodiments, the proximal end of the vitrectomy element is configured to be attached to a head component, and the distal end is configured to be attached to an ocular stabilizing element. In some embodiments, the vitrectomy element is configured to receive radiation (e.g., UVC) of a therapeutic dose from a radiation source located in the head component, and the therapeutic dose exits the vitrectomy element at the distal end of the stabilizing element. In some embodiments, the vitrectomy element is configured to include a vitreous probe configured to connect to the radiation source in the head component. In some embodiments, the vitrectomy element may have a base with a diameter of about 1 mm to about 10 mm (e.g., about 1 mm, about 2 mm, about 3 mm, about 4 mm, about 5 mm, about 6 mm, about 7 mm, about 8 mm, about 9 mm, or about 10 mm). In some embodiments, the vitrectomy element is configured to include a vitreous probe configured to be attached to the base of the vitrectomy element.In some embodiments, the vitreous probe is configured to have a length of approximately 1 mm to approximately 20 mm (for example, approximately 2 mm to approximately 19 mm, approximately 3 mm to approximately 18 mm, approximately 4 mm to approximately 17 mm, approximately 5 mm to approximately 16 mm, approximately 6 mm to approximately 15 mm, approximately 7 mm to approximately 14 mm, approximately 8 mm to approximately 13 mm, approximately 9 mm to approximately 12 mm, approximately 1 mm, approximately 2 mm, approximately 3 mm, approximately 4 mm, approximately 5 mm, approximately 6 mm, approximately 7 mm, approximately 8 mm, approximately 9 mm, approximately 10 mm, approximately 11 mm, approximately 12 mm, approximately 13 mm, approximately 14 mm, approximately 15 mm, approximately 16 mm, approximately 17 mm, approximately 18 mm, approximately 19 mm, or approximately 20 mm).In some embodiments, the vitreous probe is approximately 0.05 mm to approximately 10 mm (for example, approximately 0.05 mm, approximately 0.06 mm, approximately 0.07 mm, approximately 0.08 mm, approximately 0.09 mm, approximately 0.1 mm, approximately 0.2 mm, approximately 0.3 mm, approximately 0.4 mm, approximately 0.5 mm, approximately 0.6 mm, approximately 0.7 mm, approximately 0.8 mm, approximately 0.9 mm, approximately 1.0 mm, approximately 1.1 mm, approximately 1.2 mm, approximately 1.3 mm, approximately 1.4 mm, approximately 1.5 mm, approximately 1.6 mm, approximately 1.7 mm, approximately 1 .8mm, approximately 1.9mm, approximately 2.0mm, approximately 2.1mm, approximately 2.2mm, approximately 2.3mm, approximately 2.4mm, approximately 2.5mm, approximately 2.6mm, approximately 2.7mm, approximately 2.8mm, approximately 2.9mm, approximately 3.0mm, approximately 3.1mm, approximately 3.2 mm, approximately 3.3mm, approximately 3.4mm, approximately 3.5mm, approximately 3.6mm, approximately 3.7mm, approximately 3.8mm, approximately 3.9mm, approximately 4.0mm, approximately 4.1mm, approximately 4.2mm, approximately 4.3mm, approximately 4.4mm, approximately 4.5mm, approximately 4.6mm Approximately 4.7mm, 4.8mm, 4.9mm, 5.0mm, 5.1mm, 5.2mm, 5.3mm, 5.4mm, 5.5mm, 5.6mm, 5.7mm, 5.8mm, 5.9mm, 6.0mm, 6.1mm, 6.2mm, 6.3mm, 6.4mm, 6.5mm, 6.6mm, 6.7mm, 6.8mm, 6.9mm, 7.0mm, 7.1mm, 7.2mm, 7.3mm, 7.4mm, 7. They are configured to have a diameter of 5 mm, approximately 7.6 mm, approximately 7.7 mm, approximately 7.7 mm, approximately 7.9 mm, approximately 8.0 mm, approximately 8.1 mm, approximately 8.2 mm, approximately 8.3 mm, approximately 8.4 mm, approximately 8.5 mm, approximately 8.6 mm, approximately 8.7 mm, approximately 8.8 mm, approximately 8.9 mm, approximately 9.0 mm, approximately 9.1 mm, approximately 9.2 mm, approximately 9.3 mm, approximately 9.4 mm, approximately 9.5 mm, approximately 9.6 mm, approximately 9.7 mm, approximately 9.8 mm, approximately 9.9 mm, or approximately 10.0 mm. In some embodiments, the vitreous excision element is configured as a vitreous probe having a base with a diameter of approximately 6 mm, a length of approximately 12 mm, and a probe diameter of approximately 1 mm.

[0086] <Proximity detection element> The apparatus described herein may include a proximity detection element. The proximity detection element is a component configured to detect the distance between an energy source (e.g., UV radiation, e.g., UVC radiation) and an administration site, e.g., treatment. Since the apparatus described herein provides therapeutic radiation, it is desirable to position the apparatus at an appropriate distance to provide safe and effective energy delivery. In some embodiments, the apparatus does not directly contact the administration site. Therefore, the apparatus may include a proximity detection element that detects a predetermined distance from the administration site where the energy source is to be activated. The proximity detection element may be located on a head component or on a base component.

[0087] Any suitable mechanism can be used as the proximity detection element. For example, a light sensor can be used to detect the distance between the energy source and the administration site. In one embodiment, the proximity detection element comprises two or more light beams (e.g., lasers) that converge and align when they reach a predetermined distance. For example, if the device is preferentially positioned at a predetermined distance from the administration site, the two light beams can converge and illuminate the zone of body tissue to be irradiated when the device is properly positioned. The predetermined distance may be, for example, about 1 mm to about 100 cm from the administration site, e.g., about 1 mm to about 100 mm, about 1 mm to about 50 mm, about 1 mm to about 25 mm, about 2 mm to about 20 mm, or about 5 mm to about 10 mm, e.g., about 8 mm.

[0088] <Eye stability factors> The apparatus described herein may include an eye stabilizing element. The eye stabilizing element may have a proximal end configured to be attached to the distal end of a head component, and a distal end configured to contact the target eye. In some embodiments, the eye stabilizing element has a conical or cylindrical shape with a first diameter and a second diameter at the proximal and distal ends, respectively (parts A and B of Figure 26). In some embodiments, the first diameter is smaller than the second diameter. In some embodiments, the first diameter is larger than the second diameter. In some embodiments, the first diameter is equal to the second diameter. In some embodiments, the first and second diameters have diameters large enough to accommodate a beam of UVC radiation with a beam diameter of about 1 mm to about 15 mm (e.g., about 1 mm, about 2 mm, about 3 mm, about 4 mm, about 5 mm, about 6 mm, about 7 mm, about 8 mm, about 9 mm, about 10 mm, about 11 mm, about 12 mm, about 13 mm, about 14 mm, or about 15 mm, e.g., about 4.5 mm). In some embodiments, the first and second diameters are approximately 1 mm to approximately 20 mm (for example, approximately 2 mm to approximately 19 mm, approximately 3 mm to approximately 18 mm, approximately 4 mm to approximately 17 mm, approximately 5 mm to approximately 16 mm, approximately 6 mm to approximately 15 mm, approximately 7 mm to approximately 14 mm, approximately 8 mm to approximately 13 mm, approximately 9 mm to approximately 12 mm, approximately 1 mm, approximately 2 mm, approximately 3 mm, approximately 4 mm, approximately 5 mm, approximately 6 mm, approximately 7 mm, approximately 8 mm, approximately 9 mm, approximately 10 mm, approximately 11 mm, approximately 12 mm, approximately 13 mm, approximately 14 mm, approximately 15 mm, approximately 16 mm, approximately 17 mm, approximately 18 mm, approximately 19 mm, or approximately 20 mm).

[0089] In some embodiments, the eye stabilizing element has a first diameter of approximately 1 mm to approximately 20 mm (e.g., approximately 2 mm to approximately 19 mm, approximately 3 mm to approximately 18 mm, approximately 4 mm to approximately 17 mm, approximately 5 mm to approximately 16 mm, approximately 6 mm to approximately 15 mm, approximately 7 mm to approximately 14 mm, approximately 8 mm to approximately 13 mm, approximately 9 mm to approximately 12 mm, or approximately 10 mm to approximately 11 mm); a second diameter of approximately 1 mm to approximately 10 mm (e.g., approximately 1 mm, approximately 2 mm, approximately 3 mm, approximately 4 mm, approximately 5 mm, approximately 6 mm, approximately 7 mm, approximately 8 mm, approximately 9 mm, or approximately 10 mm); and approximately 1 mm to approximately 20 mm (e.g., approximately 2 mm to approximately 19 mm, approximately The eye stabilizing element is configured in a conical shape with a base having a length of approximately 3 mm to approximately 18 mm, approximately 4 mm to approximately 17 mm, approximately 5 mm to approximately 16 mm, approximately 6 mm to approximately 15 mm, approximately 7 mm to approximately 14 mm, approximately 8 mm to approximately 13 mm, approximately 9 mm to approximately 12 mm, or approximately 10 mm to approximately 11 mm, a treatment distance of approximately 5 mm to approximately 11 mm (e.g., approximately 6 mm to approximately 10 mm, approximately 7 mm to approximately 9 mm, or approximately 8 mm), and a length of approximately 1 mm to approximately 3 mm (e.g., approximately 2 mm), corresponding to a beam diameter of approximately 1 mm to approximately 5 mm (e.g., approximately 1 mm, approximately 2 mm, approximately 3 mm, approximately 4 mm, or approximately 5 mm). In some embodiments, the eye stabilizing element is configured in a conical shape with a first diameter of approximately 10 mm, a second diameter of approximately 6 mm, a length of approximately 10 mm, a treatment distance of approximately 8 mm, and a base of approximately 2 mm for mounting to the distal end of the UV radiation source, to accommodate a beam diameter of approximately 4.5 mm.

[0090] In some embodiments, the distal end of the eye stabilizing element has a smooth rim (Figures 27A and 27B). In some embodiments, the distal end of the eye stabilizing element has a molded rim (e.g., a fortress-like rim) and is equipped with multiple (e.g., about 2, 3, 4, 5, 6, 7, 8, 9, or 10) projections and / or grooves, such as teeth, that stabilize the eye by contact (Figure 28B). In some embodiments, the teeth are evenly distributed along the circumference of the distal end of the eye stabilizing element.In some embodiments, the teeth have a triangular shape ending at the tip, with the tip of the tooth being approximately 1° to approximately 179° (for example, 1°, 2°, 3°, 4°, 5°, 6°, 7°, 8°, 9°, 10°, 11°, 12°, 13°, 14°, 15°, 16°, 17°, 18°, 19°, 20°, 21°, 22°, 23°, 24°, 25°, 26°, 27°, 28°, 29°, 30°, 31°, 32°, 33°, 34°, 35°, 36°, 37°, 38°, 39°, 40° °, 41°, 42°, 43°, 44°, 45°, 46°, 47°, 48°, 49°, 50°, 51°, 52°, 53°, 54°, 55°, 56°, 57°, 58°, 59°, 60°, 61°, 62°, 63°, 64°, 65°, 66°, 67°, 68°, 69°, 70°, 71°, 72°, 73°, 74°, 75°, 76°, 77°, 78°, 79°, 80°, 91°, 92°, 93°, 94°, 95°, 96°, 97°, 98°, 99°, 100°, 101°, 102°, 103°, 104°, 105°, 106°, 107°, 108°, 109°, 110°, 111°, 112°, 113°, 114°, 115°, 116°, 117°, 118°, 119°, 120°, 121°, 122°, 123°, 124°, 125°, 126°, 127°, 128°, 129°, 130°, 131°, 132°, 133°, 134°, 135°, 136°, 137°, 138°, 139°, 140°, 141 The angles are 142°, 143°, 144°, 145°, 146°, 147°, 148°, 149°, 150°, 151°, 152°, 153°, 154°, 155°, 156°, 157°, 158°, 159°, 160°, 161°, 162°, 163°, 164°, 165°, 166°, 167°, 168°, 169°, 170°, 171°, 172°, 173°, 174°, 175°, 176°, 177°, 178°, or 179°. In some embodiments, the eye stabilizing element also establishes the optimal distance of the target eye from the head component.In some embodiments, the optimal distance is about 1 mm to about 20 mm (e.g., about 2 mm to about 19 mm, about 3 mm to about 18 mm, about 4 mm to about 17 mm, about 5 mm to about 16 mm, about 6 mm to about 15 mm, about 7 mm to about 14 mm, about 8 mm to about 13 mm, about 9 mm to about 12 mm, about 1 mm, about 2 mm, about 3 mm, about 4 mm, about 5 mm, about 6 mm, about 7 mm, about 8 mm, about 9 mm, about 10 mm, about 11 mm, about 12 mm, about 13 mm, about 14 mm, about 15 mm, about 16 mm, about 17 mm, about 18 mm, about 19 mm, or about 20 mm). In some embodiments, the eye stabilizing element is made of a material that does not transmit UVC light. In some embodiments, the stabilizing element is hollow from the proximal end to the distal end. In some embodiments, the eye stabilizing element is disposable and for single use only, and is equipped with a tag (e.g., a radio frequency identification (RFID) tag) to prevent the eye stabilizing element from being reused. In some embodiments, the distal end of the eye stabilizing element is shaped to have substantially small-sized features (e.g., protrusions, grooves, or teeth) that make it impossible to clean the eye stabilizing element. In some embodiments, the eye stabilizing element is not sterilizable. In some embodiments, the eye stabilizing element is made of a material that is transparent to visible light. In some embodiments, the eye stabilizing element is made of a plastic material (e.g., thermoplastic resins (e.g., polyvinyl chloride, polystyrene, polyamide, polyester, and polyurethane), polyethylene terephthalate, polyethylene, polyvinyl chloride, polypropylene, polylactic acid, polycarbonate, acrylic plastic, polyoxymethylene, nylon, or acrylonitrile butadiene styrene). In some embodiments, the eye stabilizing element is equipped with a component (e.g., a microscope) used to maintain the eyelid of the subject in an open position. In some embodiments, the eye stabilizing element has the function of providing improved grip and / or handling stability (e.g., ridges, grooves, lines, depressions, or curves).

[0091] <Signal generation element> The apparatus described herein may include a signal generating element. The signal generating element provides a signal, such as a warning or stimulus, when it detects a predetermined distance. The signal generating element may be operably connected to a proximity detection element to generate a signal when the proximity detection element detects a predetermined distance. The signal may be an auditory signal, a visual signal, or a tactile signal. For example, the signal generating element may warn a user holding the apparatus to administer a UV radiation source when a predetermined distance is reached by generating a vibration when the predetermined distance is reached. In another embodiment, the signal generating element automatically triggers the activation of a UV source, for example, by opening an aperture or supplying power to the UV source. In this embodiment, the signal generating element may also generate auditory, visual, or tactile signals. Alternatively, it may also generate an electrical signal.

[0092] <Opening control element> The apparatus described herein may include an aperture control element configured to adjust the aperture size of a UV radiation source (e.g., UVC radiation). The aperture control element may be located on a head component. For example, the aperture control element may be an accessory that fits into the head near the UV radiation source. Alternatively, the aperture control element may be integrated within the head. In one embodiment, the aperture control element is one or more cones attached to the head component. Each cone may have a different size to control the aperture size. The diameter of the aperture may be, for example, about 1 mm to about 50 mm, for example, about 2 mm to about 40 mm, for example, about 4 mm, about 8 mm, or about 25 mm. In some embodiments, the aperture control element is configured to allow 360° irradiation, for example, when used with a laryngoscope. In some embodiments, the present invention features a system comprising multiple aperture control elements, each aperture control element (e.g., cone) configured for different applications or methods of treatment depending on the intensity, output, and distance required for administration.

[0093] <Imaging Module> The apparatus described herein may include an imaging module configured to display an image of the treatment or administration site. The imaging module allows the user to receive visual feedback during UV administration. The imaging module may include, for example, a detector (e.g., a camera, e.g., a CCD camera) and a display. Suitable detectors and displays are known in the art. The imaging module may be located on a head component or a base component. In some embodiments, the detector may be located on the head component and the display on the base component. In embodiments with an optical guide, the imaging module or a part thereof (e.g., a detector or camera) may be located at the distal end of the optical guide to visualize, for example, the area closest to the distal end of the optical guide. For example, an apparatus having an optical guide configured to deliver energy to a target lumen may have a camera located at the distal end to visualize the lumen before and during administration into a body cavity. In this embodiment, the apparatus may further include, for example, an endoscope having an optical guide internally and an imaging module mounted on it.

[0094] The display may have various functions to guide the user (e.g., a clinician) during the administration of therapeutic energy. For example, it may be able to display the distance between the UV source and the administration site in real time. The display may be coupled to proximity detection elements and / or signal generation elements so that when a predetermined distance is detected between the UV source and the administration site, a visual signal can be displayed. When the predetermined distance is detected, the visual signal can instruct the user to administer therapeutic energy.

[0095] <Luminous contact lenses> The apparatus described herein may include a contact lens configured to direct UVC radiation towards a target eye. In some embodiments, the contact lens includes a UVC radiation source (e.g., incorporated into or attached to the lens). In some embodiments, the contact lens is configured to transmit UVC radiation from an external source of UVC radiation to the target eye. In some embodiments, the UVC radiation source is directed towards the target eye. In some embodiments, the radiation source may be tuned to emit radiation at a selected wavelength. In some embodiments, the contact lens is configured to diffuse the UVC radiation to illuminate the eye with a UVC beam having a substantially smooth and uniformly distributed profile. The UVC radiation source may include at least one or more light-emitting diodes (LEDs) that emit UV radiation (e.g., surface-mount device LEDs (SMDs)). For example, the radiation source may include 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more LEDs that emit UV radiation. In some embodiments, the UVC radiation can have wavelengths ranging from about 100 nm to about 280 nm (e.g., about 200 nm to about 280 nm, e.g., about 220 nm to about 280 nm, e.g., about 240 nm to 270 nm, e.g., about 250 nm to about 270 nm, or about 260 nm to about 270 nm, e.g., about 254 nm, about 255 nm, or about 265 nm). In some embodiments, the UV radiation source has a wavelength of about 0.01 mW / cm². 2 ~about 500mW / cm 2 For example, approximately 0.01 mW / cm² 2 ~about 50mW / cm 2 For example, approximately 0.01 mW / cm² 2 ~about 5mW / cm 2 It generates a radiation intensity of approximately 0.01 mW / cm². For example, a UV radiation source produces approximately 0.01 mW / cm². 2 ~about 0.1mW / cm 2 For example, approximately 0.02 mW / cm² 2 , 0.03 mW / cm 2 , 0.04 mW / cm² 2 , 0.05 mW / cm 2 , 0.06 mW / cm 2, 0.07 mW / cm 2 , 0.08 mW / cm 2 , 0.09 mW / cm² 2 , 0.1 mW / cm 2 For example, approximately 0.1 mW / cm² 2 ~about 1mW / cm 2 For example, approximately 0.2 mW / cm² 2 , 0.3 mW / cm 2 , 0.4 mW / cm 2 , 0.5 mW / cm 2 , 0.6 mW / cm 2 , 0.7 mW / cm 2 , 0.8 mW / cm 2 0.9 mW / cm² 2 , or 1 mW / cm 2 For example, from approximately 1 mW / cm² 2 ~about 10mW / cm 2 For example, approximately 2 mW / cm² 2 3mW / cm 2 4 mW / cm² 2 5 mW / cm² 2 , 6mW / cm 2 7mW / cm 2 8mW / cm 2 9 mW / cm² 2 , 10 mW / cm 2 For example, approximately 10 mW / cm² 2 ~about 100mW / cm 2 For example, approximately 20 mW / cm² 2 30 mW / cm² 2 40 mW / cm² 2 50mW / cm 2 60mW / cm² 2 70mW / cm² 2 80mW / cm² 2 90 mW / cm² 2 , or 100mW / cm² 2 For example, approximately 100 mW / cm² 2 ~about 500mW / cm 2 For example, approximately 150 mW / cm² 2 , 200mW / cm 2 , 250mW / cm 2 , 300mW / cm 2 350mW / cm² 2 , 400mW / cm2 , 450mW / cm 2 , or 500mW / cm² 2 The radiant intensity can be generated. The contact lens may have a detachable or integrated power source (e.g., a battery, energy transfer antenna, solar cell, inertial power harvester, or electrical plug). In some embodiments, the contact lens is made of a plastic material (e.g., a rigid gas permeable lens or a hybrid lens). In some embodiments, the contact lens is made of a flexible material (e.g., a flexible lens). In some embodiments, the contact lens is made of quartz (e.g., fused silica). In some embodiments, the contact lens is made of a material that directs UVC radiation towards the treatment site while blocking UVC radiation from irradiating surrounding healthy tissue.

[0096] <Additional Components> The apparatus described herein may further include additional elements that are part of the apparatus or separate from the apparatus and may be provided as a kit or system. For example, a sterilization apparatus may include, for example, a contact lens, contact lens case, or eyeglass case configured to provide ultrasound and / or UV. The apparatus described herein may further include a temperature sensor. The heat source can be configured to provide a constant temperature (for example, about 30°C to about 50°C, for example, about 31°C, 32°C, 33°C, 34°C, 35°C, 36°C, 37°C, 38°C, 39°C, 40°C, 41°C, 42°C, 43°C, 44°C, 45°C, 46°C, 47°C, 48°C, 49°C, or 50°C, for example, about 38°C to about 40°C, for example, about 38.1°C, 38.2°C, 38.3°C, 38.4°C, 38.5°C, 38.6°C, 38.7°C, 38.8°C, 38.9°C, 39°C, 39.1°C, 39.2°C, 39.3°C, 39.4°C, 39.5°C, 39.6°C, 39.7°C, 39.8°C, 39.9°C, or 40°C). In some embodiments, the heat source provides a temperature of approximately 40°C. The device may optionally include a contact sensor that detects contact between the device and the treatment site (e.g., eyelid). The device may include a microprocessor. The contact sensor may comprise a combination of an infrared (IR) contact sensing feedback emitter or sensor that sends a signal to the microprocessor upon contact. This can be used to avoid UV transmission when not blocked by the target tissue.

[0097] The device may include one or more power sources (e.g., batteries), control buttons, handles or grips, or other ergonomic features. In some embodiments, the device is part of a system comprising a slit lamp. For example, the device may be configured to be reversibly attached to a slit lamp capable of providing an energy source (e.g., UV energy, e.g., UVC energy).

[0098] In one embodiment, a system is provided for delivering multiple energy sources to a tissue site. The system comprises a base component, which has a proximal and a distal portion, the distal portion being configured to fit into one of a plurality of interchangeable heads selected from two or more of the following: a first head with a UVC radiation source; a second head with an infrared (IR) radiation source; a third head with an ultrasonic source; a fourth head with a UVA radiation source; a fifth head with a UVC radiation source, an infrared (IR) radiation source, and an ultrasonic source; and a sixth head with a microwave radiation source and a powerful pulsed light source. The first head may further comprise one or more of the following: a proximity detection element configured to detect a predetermined distance between the energy source and the administration site; a signal generating element configured to generate a signal when the proximity detection element detects the predetermined distance; an aperture control module for adjusting the energy dose; an optical guide; and an imaging module. The system may be suitable for selecting the head components based on the desired application (e.g., a therapeutic method or a sterilization technique).

[0099] <How to use> The apparatus described herein can be used to treat a number of medical indications and / or as a sterilization apparatus. In some embodiments, the apparatus may comprise one or more head components configured to transmit a combination of energy in the form of light, heat, and / or ultrasound.

[0100] <Blepharitis and Meibomian Gland Diseases> In some embodiments, the apparatus described herein can be used as a therapeutic device for treating conditions associated with meibomian gland dysfunction, such as blepharitis and meibomian gland disease (MGD). In some embodiments, the therapeutic device is configured to treat blepharitis and / or meibomian gland disease (MGD), and its configuration comprises a base component of the device and a head component which may include a UVC light source, an infrared (IR) light source, and an ultrasonic source. The device may provide heat, for example, via an infrared (IR) source from another source. In some embodiments, a treatment session using the treatment device is approximately 100nm to approximately 280nm (for example, 105nm to 275nm, 110nm to 270nm, 115nm to 265nm, 120nm to 260nm, 125nm to 255nm, 130nm to 250nm, 135nm to 245nm, 140nm to 240nm, 145nm to 235nm, 150nm to 230nm, 155nm to 225nm, 160nm to...) 220nm, 165nm~215nm, 170nm~210nm, 175nm~205nm, 180nm~200nm, 185nm~195nm, 101nm, 102nm, 103nm, 104nm, 105n m, 106nm, 107nm, 108nm, 109, 110nm, 111nm, 112nm, 113nm, 114nm, 115nm, 116nm, 117nm, 118nm, 119, 120nm, 121nm, 1 22nm, 123nm, 124nm, 125nm, 126nm, 127nm, 128nm, 129, 130nm, 131nm, 132nm, 133nm, 134nm, 135nm, 136nm, 137nm, 1 38nm, 139, 140nm, 141nm, 142nm, 143nm, 144nm, 145nm, 146nm, 147nm, 148nm, 149, 150nm, 151nm, 152nm, 153nm, 154 nm, 155nm, 156nm, 157nm, 158nm, 159, 160nm, 161nm, 162nm, 163nm, 164nm, 165nm, 166nm, 167nm, 168nm, 169, 170nm , 171nm, 172nm, 173nm, 174nm, 175nm, 176nm, 177nm, 178nm, 179, 180nm, 181nm, 182nm, 183nm, 184nm, 185nm, 186nm,187nm, 188nm, 189, 190nm, 191nm, 192nm, 193nm, 194nm, 195nm, 196nm, 197nm, 198nm, 19 9, 200nm, 201nm, 202nm, 203nm, 204nm, 205nm, 206nm, 207nm, 208nm, 209, 210nm, 211nm, 212nm, 213nm, 214nm, 215nm, 216nm, 217nm, 218nm, 219, 220nm, 221nm, 222nm, 223nm, 22 4nm, 225nm, 226nm, 227nm, 228nm, 229, 230nm, 231nm, 232nm, 233nm, 234nm, 235nm, 236n The system may include irradiation of the affected eye with UVC light of wavelengths m, 237nm, 238nm, 239, 240nm, 241nm, 242nm, 243nm, 244nm, 245nm, 246nm, 247nm, 248nm, 249, 250nm, 251nm, 252nm, 253nm, 254nm, 255nm, 256nm, 257nm, 258nm, 259, 260nm, 261nm, 262nm, 263nm, 264nm, 265nm, 266nm, 267nm, 268nm, 269, 270nm, 271nm, 272nm, 273nm, 274nm, 275nm, 276nm, 277nm, 278nm, 279, or 280nm. In some embodiments, UVC light is approximately 20 mW / cm. 2 ~Approx. 1,000mW / cm 2 For example, approximately 30 mW / cm² 2 ~about 900mW / cm 2 , about 50mW / cm 2 ~about 850mW / cm 2 , about 100mW / cm 2 ~about 800mW / cm 2 , about 150mW / cm 2 ~about 750mW / cm 2 , about 200mW / cm 2 ~about 700mW / cm 2 , about 250mW / cm 2 ~about 650mW / cm 2 , about 300mW / cm 2 ~about 600mW / cm 2 , about 350mW / cm 2 ~about 550mW / cm2 , about 400mW / cm 2 ~about 500mW / cm 2 , about 50mW / cm 2 , about 100mW / cm 2 , about 150mW / cm 2 , about 200mW / cm 2 , about 250mW / cm 2 , about 300mW / cm 2 , about 350mW / cm 2 , about 400mW / cm 2 , about 450mW / cm 2 , about 500mW / cm 2 , about 550mW / cm 2 , about 600mW / cm 2 , about 650mW / cm 2 , about 700mW / cm 2 , about 750mW / cm 2 , about 800mW / cm 2 , about 850mW / cm 2 , about 900mW / cm 2 , about 950mW / cm 2 , or approximately 1,000 mW / cm² 2It has a power density of approximately 750nm to 1,000,000nm (e.g., 760nm to 900,000nm, 770nm to 800,000nm, 780nm to 700,000nm, 790nm to 600,000nm, 800nm ​​to 500,000nm, 810nm to 400,000nm, 820nm to 300,000nm, 830nm to 200,000nm, 840nm to 100,000nm, 850nm to 90,000nm, 860nm to 80,000nm, 870nm to 70,000nm, 880nm to 60,000nm). The system may include irradiation of the affected eye with infrared (IR) light of wavelengths (00nm, 890nm~50,000nm, 900nm~40,000nm, 1,000nm~30,000nm, 1,100nm~20,000nm, 1,200nm~10,000nm, 1,300nm~5,000nm, 1,400nm~4,000nm, 1,500nm~3,000nm, 1,600nm~2,500nm, 1,700nm~2,400nm, 1,800nm~2,300nm, 1,900nm~2,200nm, or 2,000nm~2,100nm). In some embodiments, the treatment of blepharitis and / or meibomian gland disease (MGD) is performed at frequencies of approximately 1 MHz to approximately 10 MHz, for example, 1 MHz, 2 MHz, 3 MHz, 4 MHz, 5 MHz, 6 MHz, 7 MHz, 8 MHz, 9 MHz, or 10 MHz, with a power of approximately 0.1 W / cm². 2 ~Approximately 1.0W / cm² 2 For example, 0.1 W / cm² 2 , 0.2 W / cm 2 , 0.3 W / cm 2 , 0.4 W / cm 2 , 0.5W / cm 2 , 0.6 W / cm 2 , 0.7 W / cm 2 , 0.8 W / cm 2 , 0.9 W / cm 2 , or 1.0 W / cm² 2 Ultrasound of a certain intensity may be required. In some embodiments, infrared (IR) light is approximately 20 mW / cm². 2 ~Approx. 1,000mW / cm 2 For example, approximately 30 mW / cm² 2~about 900mW / cm 2 , about 50mW / cm 2 ~about 850mW / cm 2 , about 100mW / cm 2 ~about 800mW / cm 2 , about 150mW / cm 2 ~about 750mW / cm 2 , about 200mW / cm 2 ~about 700mW / cm 2 , about 250mW / cm 2 ~about 650mW / cm 2 , about 300mW / cm 2 ~about 600mW / cm 2 , about 350mW / cm 2 ~about 550mW / cm 2 , about 400mW / cm 2 ~about 500mW / cm 2 , about 50mW / cm 2 , about 100mW / cm 2 , about 150mW / cm 2 , about 200mW / cm 2 , about 250mW / cm 2 , about 300mW / cm 2 , about 350mW / cm 2 , about 400mW / cm 2 , about 450mW / cm 2 , about 500mW / cm 2 , about 550mW / cm 2 , about 600mW / cm 2 , about 650mW / cm 2 , about 700mW / cm 2 , about 750mW / cm 2 , about 800mW / cm 2 , about 850mW / cm 2 , about 900mW / cm 2 , about 950mW / cm 2 , or approximately 1,000 mW / cm² 2It has a power density and can be continuous or pulsed illumination. In some embodiments, the treatment of blepharitis and / or meibomian gland disease (MGD) using the treatment device comprises multiple treatment sessions (e.g., weekly, monthly, quarterly, semi-annually, or yearly) and may comprise any combination of the aforementioned treatment procedures. In some embodiments, the treatment device is configured to transmit ultrasound with a transducer mounted on a stainless steel plate. In some embodiments, the physician providing the treatment may use a contact footplate that controls the activation of ultrasound, a heating pad, and UVC light. In some embodiments, the distal end of the head component may include a contact sensing element that communicates with a microprocessor that controls the UVC light. In further embodiments, the contact sensing element signals to the microprocessor whether there is contact with the treatment site to avoid irradiating surrounding healthy tissue with UVC light. When the contact sensor is activated, in some embodiments, UVC irradiation and ultrasound are initiated. In some embodiments, the device remains in contact after UVC irradiation and continues to transmit heat and ultrasound. In some embodiments, once the treatment cycle is complete, the ultrasound and heat are stopped, and a signal generator notifies the operator to remove the device. In further embodiments, whenever the device is prematurely removed from the eyelid, all light and ultrasound emissions are paused until contact is resumed.

[0101] <Cancer> In some embodiments, the devices described herein can be used as therapeutic devices for treating cancer (e.g., leukemia, seminoma, melanoma, teratoma, lymphoma, neuroblastoma, glioma, rectal cancer, endometrial cancer, kidney cancer, adrenal cancer, thyroid cancer, hematological cancer, skin cancer, brain cancer, cervical cancer, intestinal cancer, liver cancer, colon cancer, gastric cancer, intestinal cancer, head and neck cancer, digestive cancer, lymph node cancer, esophageal cancer, colorectal cancer, pancreatic cancer, otolaryngeal cancer (ENT), breast cancer, prostate cancer, uterine cancer, ovarian cancer, lung cancer and its metastases. Examples include lung carcinoma, breast carcinoma, prostate carcinoma, colon carcinoma, renal cell carcinoma, cervical carcinoma, or metastases from the above types of cancer or tumors). In some embodiments, for example, devices and methods for treating cancer, abnormal proliferation and / or dysplasia comprising cancer cells or precancerous cells may be used. In some embodiments, the therapeutic device is configured to treat cancer, and its configuration comprises a base component of the device and a head component which may include a UVC light source. The device may also include a proximity detection element and a signal generation element. In some embodiments, the device further includes an optical guide and / or imaging module. In some embodiments, a therapeutic session using the therapeutic device is in the range of approximately 100 nm to approximately 280 nm (e.g., 105 nm to 275 nm, 110 nm to 270 nm, 115 nm to 265 nm, 120 nm to 260 nm, 125 nm to 255 nm, 130 nm to 250 nm, 135 nm to 245 nm, 140 nm to 240 nm, 145 nm to 235 nm, 150 nm to 230 nm, 155 nm to 225 nm, 160 nm to 220 nm, 165 nm to 215 nm, 170 nm to 210 nm, 175 nm to 20 5nm, 180nm~200nm, 185nm~195nm, 101nm, 102nm, 103nm, 104nm, 105nm, 106nm, 107nm, 108nm, 109, 110nm, 111nm, 112nm, 113nm, 114nm, 115 nm, 116nm, 117nm, 118nm, 119, 120nm, 121nm, 122nm, 123nm, 124nm, 125nm, 126nm, 127nm, 128nm, 129, 130nm, 131nm, 132nm, 133nm, 134nm,135nm, 136nm, 137nm, 138nm, 139, 140nm, 141nm, 142nm, 143nm, 144nm, 145nm, 146nm, 147nm, 148nm, 149, 150nm, 151nm, 152nm, 153nm , 154nm, 155nm, 156nm, 157nm, 158nm, 159, 160nm, 161nm, 162nm, 163nm, 164nm, 165nm, 166nm, 167nm, 168nm, 169, 170nm, 171nm, 172nm , 173nm, 174nm, 175nm, 176nm, 177nm, 178nm, 179, 180nm, 181nm, 182nm, 183nm, 184nm, 185nm, 186nm, 187nm, 188nm, 189, 190nm, 191nm , 192nm, 193nm, 194nm, 195nm, 196nm, 197nm, 198nm, 199, 200nm, 201nm, 202nm, 203nm, 204nm, 205nm, 206nm, 207nm, 208nm, 209, 210nm , 211nm, 212nm, 213nm, 214nm, 215nm, 216nm, 217nm, 218nm, 219, 220nm, 221nm, 222nm, 223nm, 224nm, 225nm, 226nm, 227nm, 228nm, 22 9, 230nm, 231nm, 232nm, 233nm, 234nm, 235nm, 236nm, 237nm, 238nm, 239, 240nm, 241nm, 242nm, 243nm, 244nm, 245nm, 246nm, 247nm, 24 The treatment may include irradiation of the affected area with UVC light of wavelengths of 8nm, 249, 250nm, 251nm, 252nm, 253nm, 254nm, 255nm, 256nm, 257nm, 258nm, 259, 260nm, 261nm, 262nm, 263nm, 264nm, 265nm, 266nm, 267nm, 268nm, 269, 270nm, 271nm, 272nm, 273nm, 274nm, 275nm, 276nm, 277nm, 278nm, 279, or 280nm. In some embodiments, the UVC light is approximately 20mW / cm. 2 ~Approx. 1,000mW / cm 2 For example, approximately 30 mW / cm² 2 ~about 900mW / cm 2 , about 50mW / cm2 ~about 850mW / cm 2 , about 100mW / cm 2 ~about 800mW / cm 2 , about 150mW / cm 2 ~about 750mW / cm 2 , about 200mW / cm 2 ~about 700mW / cm 2 , about 250mW / cm 2 ~about 650mW / cm 2 , about 300mW / cm 2 ~about 600mW / cm 2 , about 350mW / cm 2 ~about 550mW / cm 2 , about 400mW / cm 2 ~about 500mW / cm 2 , about 50mW / cm 2 , about 100mW / cm 2 , about 150mW / cm 2 , about 200mW / cm 2 , about 250mW / cm 2 , about 300mW / cm 2 , about 350mW / cm 2 , about 400mW / cm 2 , about 450mW / cm 2 , about 500mW / cm 2 , about 550mW / cm 2 , about 600mW / cm 2 , about 650mW / cm 2 , about 700mW / cm 2 , about 750mW / cm 2 , about 800mW / cm 2 , about 850mW / cm 2 , about 900mW / cm 2 , about 950mW / cm 2 , or approximately 1,000 mW / cm² 2It has a power density and can be continuous or pulsed illumination. In some embodiments, cancer treatment can be continuous or pulsed illumination. In some embodiments where the illumination is pulsed, the pulse frequency is about 20 Hz to about 1,000 Hz, for example, about 50 Hz to about 950 Hz, about 100 Hz to about 900 Hz, about 150 Hz to about 850 Hz, about 200 Hz to about 800 Hz, about 250 Hz to about 750 Hz, about 300 Hz to about 700 Hz, about 350 Hz to about 650 Hz, about 400 Hz to about 600 Hz, about 450 Hz to about 550 Hz, about 500 Hz to about 525 Hz, about 50 Hz, about 100 Hz The frequency ranges are approximately 150Hz, 200Hz, 250Hz, 300Hz, 350Hz, 400Hz, 450Hz, 500Hz, 550Hz, 600Hz, 650Hz, 700Hz, 750Hz, 800Hz, 850Hz, 900Hz, 950Hz, and 1,000Hz. The duty cycle can be 1-100% (e.g., 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%). In some embodiments, cancer treatment using the device may comprise multiple treatment sessions and any combination of the aforementioned treatment procedures. In further embodiments, illumination may be controlled by a footplate. In some embodiments, a proximity detection element is connected to a light guide and communicates with a microprocessor that controls the irradiation. In some embodiments, irradiation is initiated only when the output end of the light guide reaches a predetermined distance from the treatment site. In some embodiments, once the treatment cycle is complete, the UVC source stops and the signal generator notifies the operator to remove the device. In further embodiments, whenever the device is removed prematurely from the treatment site, all light emission and pause occur until the predetermined distance is restored.

[0102] <Ocular cancer, orbital cancer, and / or adnexal cancer> In some embodiments, the apparatus described herein can be used as a therapeutic apparatus for treating and / or providing adjunctive treatment of ocular cancer, orbital cancer, and / or adnexal cancer (e.g., intraocular secondary tumors, retinoblastoma, uveal melanoma, conjunctival melanoma, orbital cancer, eyelid cancer, or adnexal cancer). In some embodiments, the therapeutic apparatus is configured to treat ocular cancer and comprises a base component of the apparatus and a head component which may include a UVC light source. The apparatus may also include proximity detection elements and signal generation elements. In some embodiments, the apparatus further comprises an optical guide and / or an imaging module. In some embodiments, the apparatus is a contact lens described herein and is used to deliver a therapeutic dose of UVC to the eye in order to treat ocular cancer. In some embodiments, a treatment session using the treatment device is approximately 100nm to approximately 280nm (for example, 105nm to 275nm, 110nm to 270nm, 115nm to 265nm, 120nm to 260nm, 125nm to 255nm, 130nm to 250nm, 135nm to 245nm, 140nm to 240nm, 145nm to 235nm, 15 0nm~230nm, 155nm~225nmnm, 160nm~220nm, 165nm~215nm, 170nm~210nm, 175nm~205nm, 180nm~2 00nm, 185nm~195nm, 101nm, 102nm, 103nm, 104nm, 105nm, 106nm, 107nm, 108nm, 109, 110nm, 111n m, 112nm, 113nm, 114nm, 115nm, 116nm, 117nm, 118nm, 119, 120nm, 121nm, 122nm, 123nm, 124nm, 1 25nm, 126nm, 127nm, 128nm, 129, 130nm, 131nm, 132nm, 133nm, 134nm, 135nm, 136nm, 137nm, 138n m, 139, 140nm, 141nm, 142nm, 143nm, 144nm, 145nm, 146nm, 147nm, 148nm, 149, 150nm, 151nm, 152 nm, 153nm, 154nm, 155nm, 156nm, 157nm, 158nm, 159, 160nm, 161nm, 162nm, 163nm, 164nm, 165nm,166nm, 167nm, 168nm, 169, 170nm, 171nm, 172nm, 173nm, 174nm, 175nm, 176nm, 177nm, 178nm, 179, 180nm, 1 81nm, 182nm, 183nm, 184nm, 185nm, 186nm, 187nm, 188nm, 189, 190nm, 191nm, 192nm, 193nm, 194nm, 195nm, 196nm, 197nm, 198nm, 199, 200nm, 201nm, 202nm, 203nm, 204nm, 205nm, 206nm, 207nm, 208nm, 209, 210nm, 2 11nm, 212nm, 213nm, 214nm, 215nm, 216nm, 217nm, 218nm, 219, 220nm, 221nm, 222nm, 223nm, 224nm, 225nm, 2 26nm, 227nm, 228nm, 229, 230nm, 231nm, 232nm, 233nm, 234nm, 235nm, 236nm, 237nm, 238nm, 239, 240nm, 24 1nm, 242nm, 243nm, 244nm, 245nm, 246nm, 247nm, 248nm, 249, 250nm, 251nm, 252nm, 253nm, 254nm, 255nm, 2 The treatment may include irradiation of the affected eye with UVC light of wavelengths of 56nm, 257nm, 258nm, 259, 260nm, 261nm, 262nm, 263nm, 264nm, 265nm, 266nm, 267nm, 268nm, 269, 270nm, 271nm, 272nm, 273nm, 274nm, 275nm, 276nm, 277nm, 278nm, 279, or 280nm. In some embodiments, the UVC light is approximately 20mW / cm². 2 ~Approx. 1,000mW / cm 2 For example, approximately 30 mW / cm² 2 ~about 900mW / cm 2 , about 50mW / cm 2 ~about 850mW / cm 2 , about 100mW / cm 2 ~about 800mW / cm 2 , about 150mW / cm 2 ~about 750mW / cm 2 , about 200mW / cm 2 ~about 700mW / cm 2, about 250mW / cm 2 ~about 650mW / cm 2 , about 300mW / cm 2 ~about 600mW / cm 2 , about 350mW / cm 2 ~about 550mW / cm 2 , about 400mW / cm 2 ~about 500mW / cm 2 , about 50mW / cm 2 , about 100mW / cm 2 , about 150mW / cm 2 , about 200mW / cm 2 , about 250mW / cm 2 , about 300mW / cm 2 , about 350mW / cm 2 , about 400mW / cm 2 , about 450mW / cm 2 , about 500mW / cm 2 , about 550mW / cm 2 , about 600mW / cm 2 , about 650mW / cm 2 , about 700mW / cm 2 , about 750mW / cm 2 , about 800mW / cm 2 , about 850mW / cm 2 , about 900mW / cm 2 , about 950mW / cm 2 , or approximately 1,000 mW / cm² 2It has a power density and can be continuous or pulsed illumination. In some embodiments, the treatment of eye cancer can be continuous or pulsed illumination. In some embodiments where the illumination is pulsed, the pulse frequency is about 20 Hz to about 1,000 Hz, for example, about 50 Hz to about 950 Hz, about 100 Hz to about 900 Hz, about 150 Hz to about 850 Hz, about 200 Hz to about 800 Hz, about 250 Hz to about 750 Hz, about 300 Hz to about 700 Hz, about 350 Hz to about 650 Hz, about 400 Hz to about 600 Hz, about 450 Hz to about 550 Hz, about 500 Hz to about 525 Hz, about 50 Hz, about 100 Hz Hz, approximately 150Hz, approximately 200Hz, approximately 250Hz, approximately 300Hz, approximately 350Hz, approximately 400Hz, approximately 450Hz, approximately 500Hz, approximately 550Hz, approximately 600Hz, approximately 650Hz, approximately 700Hz, approximately 750Hz, approximately 800Hz, approximately 850Hz, approximately 900Hz, approximately 950Hz, approximately 1,000Hz, and the duty cycle can be 1-100% (e.g., 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%). In some embodiments, the treatment of ocular cancer using the device may consist of multiple treatment sessions and may consist of any combination of the treatment procedures described above. In some embodiments, the treatment device may be mounted on a slit lamp device. In further embodiments, the illumination may be controlled by a footplate. In further embodiments, the ocular cancer may be intraocular, ocular surface, eyelid, or orbital cancer. In some embodiments, a light guide can be introduced into the internal space of the eye to deliver a therapeutic dose of UVC radiation to an intraocular or orbital cancer. In some embodiments, a proximity determination element is connected to the light guide and communicates with a microprocessor that controls the irradiation. In some embodiments, irradiation is initiated only when the output end of the light guide reaches a predetermined distance from the treatment site. In some embodiments, once the treatment cycle is complete, the UVC source stops and a signal generator notifies the operator to remove the device. In further embodiments, whenever the device is removed prematurely from the treatment site, all light emission and pause occur until the predetermined distance is restored.

[0103] <Acne vulgaris and rosacea> In some embodiments, the apparatus described herein can be used as a therapeutic apparatus for treating acne vulgaris and / or rosacea. In some embodiments, the therapeutic apparatus is configured to treat acne and comprises a base component of the apparatus and a head component which may include a UVC light source. In some embodiments, a therapeutic session using the apparatus may have a wavelength range of 100nm to 280nm (e.g., 105nm to 275nm, 110nm to 270nm, 115nm to 265nm, 120nm to 260nm, 125nm to 255nm, 130nm to 250nm, 135nm to 245nm, 140nm to 240nm, 145nm to 235nm, 150nm to 230nm, 155nm to 225nm, 160nm to 220nm, 165nm to 215nm, 170nm to 21nm). 0nm, 175nm~205nm, 180nm~200nm, 185nm~195nm, 101nm, 102nm, 103nm, 104nm, 105nm, 106nm, 107nm, 108nm, 109, 110nm, 111nm, 1 12nm, 113nm, 114nm, 115nm, 116nm, 117nm, 118nm, 119, 120nm, 121nm, 122nm, 123nm, 124nm, 125nm, 126nm, 127nm, 128nm, 129, 130 nm, 131nm, 132nm, 133nm, 134nm, 135nm, 136nm, 137nm, 138nm, 139, 140nm, 141nm, 142nm, 143nm, 144nm, 145nm, 146nm, 147nm, 14 8nm, 149, 150nm, 151nm, 152nm, 153nm, 154nm, 155nm, 156nm, 157nm, 158nm, 159, 160nm, 161nm, 162nm, 163nm, 164nm, 165nm, 166 nm, 167nm, 168nm, 169, 170nm, 171nm, 172nm, 173nm, 174nm, 175nm, 176nm, 177nm, 178nm, 179, 180nm, 181nm, 182nm, 183nm, 184n m, 185nm, 186nm, 187nm, 188nm, 189, 190nm, 191nm, 192nm, 193nm, 194nm, 195nm, 196nm, 197nm, 198nm, 199, 200nm, 201nm, 202nm,203nm, 204nm, 205nm, 206nm, 207nm, 208nm, 209, 210nm, 211nm, 212nm, 21 3nm, 214nm, 215nm, 216nm, 217nm, 218nm, 219, 220nm, 221nm, 222nm, 223nm , 224nm, 225nm, 226nm, 227nm, 228nm, 229, 230nm, 231nm, 232nm, 233nm, 23 4nm, 235nm, 236nm, 237nm, 238nm, 239, 240nm, 241nm, 242nm, 243nm, 244nm The method may include irradiation of the affected area of ​​skin with UVC light having wavelengths of 245nm, 246nm, 247nm, 248nm, 249, 250nm, 251nm, 252nm, 253nm, 254nm, 255nm, 256nm, 257nm, 258nm, 259, 260nm, 261nm, 262nm, 263nm, 264nm, 265nm, 266nm, 267nm, 268nm, 269, 270nm, 271nm, 272nm, 273nm, 274nm, 275nm, 276nm, 277nm, 278nm, 279, or 280nm. In some embodiments, the UVC light is approximately 20mW / cm². 2 ~Approx. 1,000mW / cm 2 For example, approximately 30 mW / cm² 2 ~about 900mW / cm 2 , about 50mW / cm 2 ~about 850mW / cm 2 , about 100mW / cm 2 ~about 800mW / cm 2 , about 150mW / cm 2 ~about 750mW / cm 2 , about 200mW / cm 2 ~about 700mW / cm 2 , about 250mW / cm 2 ~about 650mW / cm 2 , about 300mW / cm 2 ~about 600mW / cm 2 , about 350mW / cm 2 ~about 550mW / cm 2 , about 400mW / cm 2 ~about 500mW / cm 2 , about 50mW / cm 2 , about 100mW / cm2 , about 150mW / cm 2 , about 200mW / cm 2 , about 250mW / cm 2 , about 300mW / cm 2 , about 350mW / cm 2 , about 400mW / cm 2 , about 450mW / cm 2 , about 500mW / cm 2 , about 550mW / cm 2 , about 600mW / cm 2 , about 650mW / cm 2 , about 700mW / cm 2 , about 750mW / cm 2 , about 800mW / cm 2 , about 850mW / cm 2 , about 900mW / cm 2 , about 950mW / cm 2 , or approximately 1,000 mW / cm² 2It has a power density and can be continuous or pulsed illumination. In some embodiments, acne treatment can be continuous or pulsed illumination. In some embodiments where the illumination is pulsed, the pulse frequency is about 20 Hz to about 1,000 Hz, for example, about 50 Hz to about 950 Hz, about 100 Hz to about 900 Hz, about 150 Hz to about 850 Hz, about 200 Hz to about 800 Hz, about 250 Hz to about 750 Hz, about 300 Hz to about 700 Hz, about 350 Hz to about 650 Hz, about 400 Hz to about 600 Hz, about 450 Hz to about 550 Hz, about 500 Hz to about 525 Hz, about 50 Hz, about 100 Hz Hz, approximately 150Hz, approximately 200Hz, approximately 250Hz, approximately 300Hz, approximately 350Hz, approximately 400Hz, approximately 450Hz, approximately 500Hz, approximately 550Hz, approximately 600Hz, approximately 650Hz, approximately 700Hz, approximately 750Hz, approximately 800Hz, approximately 850Hz, approximately 900Hz, approximately 950Hz, approximately 1,000Hz, and the duty cycle can be 1-100% (e.g., 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%). In some embodiments, the treatment of acne using the device may consist of multiple treatment sessions (e.g., weekly, monthly, quarterly, semi-annually, or yearly) and may consist of any combination of the treatment procedures described above. In some embodiments, the treatment device may be mounted on a slit lamp device. In further embodiments, the lighting may be controlled by a footplate. In some embodiments, the optical guide can be directed towards the affected area of ​​skin to deliver a therapeutic dose of UVC radiation. In some embodiments, a proximity determination element is connected to the optical guide and communicates with a microprocessor that controls the irradiation. In some embodiments, irradiation is initiated only when the output end of the optical guide reaches a predetermined distance from the treatment site. In some embodiments, once the treatment cycle is complete, the UVC source stops and a signal generator notifies the operator to remove the device. In further embodiments, whenever the device is removed prematurely from the treatment site, all light emission is paused until the predetermined distance is restored.

[0104] <Wound healing (e.g., gastric ulcer or duodenal ulcer)> In some embodiments, the apparatus described herein can be used as a therapeutic device for treating wounds and improving wound healing (e.g., speed of healing, degree of healing, and / or reduction of scarring). In some embodiments, the apparatus is configured to treat gastric or duodenal ulcers (e.g., those caused by H. pylori (Helicobacter pylori) infection), abrasions, surgical incisions, recurrent corneal erosions, corneal ulcers, infections, burns, eyelid and skin trauma, abrasions due to trauma or foreign bodies, cosmetic surgery, blepharoplasty, cataract surgery incisions, refractive surgery incisions and / or flaps, puncture wounds, suture-related inflammation, rotational flaps, pedicle flaps, or skin grafts. In some embodiments, the therapeutic device is configured to treat gastric or duodenal ulcers, and its configuration comprises a base component of the device and a head component which may include a UV source. In some embodiments, a treatment session using a wound healing configuration of a treatment device (e.g., a gastric ulcer or duodenal ulcer configuration) uses a wavelength range of 100nm to 280nm (e.g., 105nm to 275nm, 110nm to 270nm, 115nm to 265nm, 120nm to 260nm, 125nm to 255nm, 130nm to 250nm, 135nm to 245nm, 140nm to 240nm, 145nm to 235nm, 150nm to 230nm, 155nm to 225nm, 160nm to 220nm, 165nm to 215nm, 170nm to 210nm, 175nm to 205nm, 180nm to 200nm, 185nm to 195nm, 101nm, 102nm, 103nm, 10 4nm, 105nm, 106nm, 107nm, 108nm, 109, 110nm, 111nm, 112nm, 113nm, 114nm, 115nm, 116nm, 1 17nm, 118nm, 119, 120nm, 121nm, 122nm, 123nm, 124nm, 125nm, 126nm, 127nm, 128nm, 129, 13 0nm, 131nm, 132nm, 133nm, 134nm, 135nm, 136nm, 137nm, 138nm, 139, 140nm, 141nm, 142nm, 1 43nm, 144nm, 145nm, 146nm, 147nm, 148nm, 149, 150nm, 151nm, 152nm, 153nm, 154nm, 155nm,156nm, 157nm, 158nm, 159, 160nm, 161nm, 162nm, 163nm, 164nm, 165nm, 166nm, 167nm, 168nm, 169, 170nm, 171nm, 17 2nm, 173nm, 174nm, 175nm, 176nm, 177nm, 178nm, 179, 180nm, 181nm, 182nm, 183nm, 184nm, 185nm, 186nm, 187nm, 188 nm, 189, 190nm, 191nm, 192nm, 193nm, 194nm, 195nm, 196nm, 197nm, 198nm, 199, 200nm, 201nm, 202nm, 203nm, 204nm, 205nm, 206nm, 207nm, 208nm, 209, 210nm, 211nm, 212nm, 213nm, 214nm, 215nm, 216nm, 217nm, 218nm, 219, 220nm, 221 nm, 222nm, 223nm, 224nm, 225nm, 226nm, 227nm, 228nm, 229, 230nm, 231nm, 232nm, 233nm, 234nm, 235nm, 236nm, 237 nm, 238nm, 239, 240nm, 241nm, 242nm, 243nm, 244nm, 245nm, 246nm, 247nm, 248nm, 249, 250nm, 251nm, 252nm, 253nm, The method may include irradiation of the wound area with UVC light of wavelengths of 254nm, 255nm, 256nm, 257nm, 258nm, 259, 260nm, 261nm, 262nm, 263nm, 264nm, 265nm, 266nm, 267nm, 268nm, 269, 270nm, 271nm, 272nm, 273nm, 274nm, 275nm, 276nm, 277nm, 278nm, 279, or 280nm. In some embodiments, the UVC light is approximately 1 to mJ / cm. 2 ~Approx. 5000mJ / cm 2 For example, approximately 50 mJ / cm² 2 ~Approx. 4500mJ / cm 2 , about 100mJ / cm 2 ~About 4000mJ / cm 2 , about 200mJ / cm 2 ~About 4000mJ / cm 2 , about 300mJ / cm 2 ~Approx. 3500mJ / cm2 , about 500mJ / cm 2 ~Approx. 3000mJ / cm 2 , about 1,000mJ / cm 2 ~Approx. 2500mJ / cm 2 , about 1500mJ / cm 2 ~About 2000mJ / cm 2 , about 100mJ / cm 2 , about 200mJ / cm 2 , about 300mJ / cm 2 , about 400mJ / cm 2 , about 500mJ / cm 2 , about 600mJ / cm 2 , about 700mJ / cm 2 , about 800mJ / cm 2 , about 900mJ / cm 2 , about 1,000mJ / cm 2 , about 1500mJ / cm 2 , about 2000mJ / cm 2 , about 2500mJ / cm 2 , about 3000mJ / cm 2 , about 3500mJ / cm 2 , about 4000mJ / cm 2 , about 4500mJ / cm 2 , about 5000mJ / cm 2 It has a power density and can be continuous or pulsed illumination. In some embodiments, the UVC light source may be an LED having a light output of 0.2 mW to 0.3 mW. In some embodiments, the intensity of the UVC LED light on the target tissue (e.g., wound) may depend on the area of ​​the target tissue being irradiated (e.g., about 1 cm²). 2 For the target tissue region, the intensity is approximately 0.3 mW / cm². 2 It is approximately 4.3m m2 For a given target tissue area, the intensity is approximately 2.07 mW / cm². 2 In some embodiments, the total UVC dose to the target tissue depends on the duration of the illumination session (e.g., about 4.3 m). m2 For target tissue with a surface area of ​​approximately 2.07 mW / cm², the intensity is approximately 2.07 mW / cm². 2 The total UVC dose over 15 seconds was approximately 31 mJ / cm². 2(This is the case.) In some embodiments where the lighting is pulsed, the pulse frequency is approximately 20Hz to approximately 1,000Hz, for example, approximately 50Hz to approximately 950Hz, approximately 100Hz to approximately 900Hz, approximately 150Hz to approximately 850Hz, approximately 200Hz to approximately 800Hz, approximately 250Hz to approximately 750Hz, approximately 300Hz to approximately 700Hz, approximately 350Hz to approximately 650Hz, approximately 400Hz to approximately 600Hz, approximately 450Hz to approximately 550Hz, approximately 500Hz to approximately 525Hz, approximately 50Hz, approximately 100Hz Hz, approximately 150Hz, approximately 200Hz, approximately 250Hz, approximately 300Hz, approximately 350Hz, approximately 400Hz, approximately 450Hz, approximately 500Hz, approximately 550Hz, approximately 600Hz, approximately 650Hz, approximately 700Hz, approximately 750Hz, approximately 800Hz, approximately 850Hz, approximately 900Hz, approximately 950Hz, approximately 1,000Hz, and the duty cycle may be 1-100% (e.g., 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%). In some embodiments, the treatment of a wound, or a gastric or duodenal ulcer, may consist of multiple treatment sessions (e.g., weekly, monthly, quarterly, semi-annually, or annually), and may consist of any combination of the aforementioned treatment procedures. In further embodiments, the lighting may be controlled by a footplate. In some embodiments, the optical guide can be introduced to or positioned near the affected area of ​​an internal wound (e.g., a gastrointestinal wound) to deliver a therapeutic dose of UVC radiation. In some embodiments, a proximity determination element is connected to the optical guide and communicates with a microprocessor that controls the irradiation. In some embodiments, irradiation is initiated only when the output end of the optical guide reaches a predetermined distance from the treatment site. In some embodiments, once the treatment cycle is complete, the UVC source is shut off and a signal generator notifies the operator to remove the device. In further embodiments, whenever the device is removed prematurely from the treatment site, all light emission is paused until the predetermined distance is restored. The method of treating a wound by delivering a therapeutic dose of UVC radiation can incorporate any combination of UVC and other energy sources described herein (e.g., infrared (IR) radiation, UVA radiation, microwaves, and / or ultrasound).

[0105] <Sterilization of the tissue and / or reduction of the harmful microorganism load> In some embodiments, the apparatus described herein can be used as a sterilization apparatus for sterilizing tissue or for reducing the microbial load (e.g., viruses, bacteria, protozoa, symbiotic organisms, parasites, fungi, nematodes, viroids, or any combination thereof) within tissue. In some embodiments, the sterilization apparatus can reduce the microbial load (e.g., Chlamydiatrachomatous infection, Demodex folliculorum infection, endophthalmitis, bacterial conjunctivitis, adenovirus conjunctivitis, herpesvirus, human papillomavirus, coronavirus, e.g., SARS-CoV-2). In some embodiments, the sterilization device is configured to sterilize tissue (e.g., internal areas of the mouth to treat periodontitis, and / or external areas of the mouth to treat gingivitis, e.g., lips, nasal cavity, oropharynx, reproductive tract, ureter, gastrointestinal tract, external areas of the eye, internal areas of the eye, ear, genitals, body lumen), and the configuration includes a base component of the device and a head component which may include a UV source, proximity detection elements, and a light guide. In some embodiments, the device is configured to sterilize and / or reduce the load of harmful microorganisms in tooth infections or dental tracts (e.g., at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 97%, 99%, and 100%). In some embodiments, the device is configured to sterilize internal areas of the mouth (e.g., teeth, tooth cavities, and / or areas surrounding teeth), e.g., during the process of root canal treatment. In some embodiments, the device comprises a contact lens described herein to kill or reduce viral and / or bacterial loads in the eye by delivering a therapeutic dose of UVC to the eye. In some embodiments, the device is configured to treat gingivitis and comprises a shield molded to deliver a therapeutic dose or UVC to the target gingival tissue while preventing the UVC from being transmitted outside the gingival tissue. In some embodiments, the UVC radiation source is directed to the anterior region, posterior region, vitreous cavity region, retinal region, choroidal region, macular region, lens region (e.g., intraocular lens region), ciliary muscle region, or optic nerve region of the eye.It is configured to deliver a therapeutic dose of UVC radiation. In some embodiments, the therapeutic dose of UVC is delivered to the target eye via a vitrectomy element. In some embodiments, the UVC radiation source is inserted into a vitrectomy element and configured to deliver a therapeutic dose of UVC radiation directly to the target eye. In some embodiments, the UVC radiation source is configured to deliver a therapeutic dose of UVC radiation through a vitrectomy element using an optical guide. In some embodiments, the optical guide (e.g., a vitreous probe) has a diameter of approximately 1 mm to approximately 20 mm (e.g., approximately 2 mm to approximately 19 mm, approximately 3 mm to approximately 18 mm, approximately 4 mm to approximately 17 mm, approximately 5 mm to approximately 16 mm, approximately 6 mm to approximately 15 mm, approximately 7 mm to approximately 14 mm, approximately 8 mm to approximately 13 mm, approximately 9 mm to approximately 12 mm, approximately 1 mm, approximately 2 mm, approximately 3 mm, approximately 4 mm, approximately 5 mm, approximately 6 mm, approximately 7 mm, approximately 8 mm, approximately 9 mm, approximately 10 mm, approximately 11 mm, approximately 12 mm, approximately 13 mm, approximately 14 mm, approximately 15 mm, approximately 16 mm, approximately 17 mm, approximately 18 mm, approximately 19 mm, or approximately 20 mm). In some embodiments, the optical guide has a length of approximately 1 mm to approximately 20 mm (for example, approximately 2 mm to approximately 19 mm, approximately 3 mm to approximately 18 mm, approximately 4 mm to approximately 17 mm, approximately 5 mm to approximately 16 mm, approximately 6 mm to approximately 15 mm, approximately 7 mm to approximately 14 mm, approximately 8 mm to approximately 13 mm, approximately 9 mm to approximately 12 mm, approximately 1 mm, approximately 2 mm, approximately 3 mm, approximately 4 mm, approximately 5 mm, approximately 6 mm, approximately 7 mm, approximately 8 mm, approximately 9 mm, approximately 10 mm, approximately 11 mm, approximately 12 mm, approximately 13 mm, approximately 14 mm, approximately 15 mm, approximately 16 mm, approximately 17 mm, approximately 18 mm, approximately 19 mm, or approximately 20 mm) (for example, the length of the vitreous probe). In some embodiments, the sterilization session using the device covers a range of wavelengths from 100nm to 280nm (e.g., 105nm to 275nm, 110nm to 270nm, 115nm to 265nm, 120nm to 260nm, 125nm to 255nm, 130nm to 250nm, 135nm to 245nm, 140nm to 240nm, 145nm to 235nm, 150nm to 230nm, 155nm to 225nm, 160nm to 220nm, 165nm to 215nm, 170nm to 210nm, 175nm to 205nm, 180nm to 200nm, 185nm to 195nm, 101nm, 102nm, 103nm, 104nm, 105nm,106nm、107nm、108nm、109、110nm、111nm、112nm、113nm、114nm、115nm、116nm、117nm、118nm、119、120nm、121nm、122nm、123nm、124nm、125nm、126nm、127nm、128nm、129、130nm、131nm、132nm、133nm、134nm、135nm、136nm、137nm、138nm、139、140nm、141nm、142nm、143nm、144nm、145nm、146nm、147nm、148nm、149、150nm、151nm、152nm、153nm、154nm、155nm、156nm、157nm、158nm、159、160nm、161nm、162nm、163nm、164nm、165nm、166nm、167nm、168nm、169、170nm、171nm、172nm、173nm、174nm、175nm、176nm、177nm、178nm、179、180nm、181nm、182nm、183nm、184nm、185nm、186nm、187nm、188nm、189、190nm、191nm、192nm、193nm、194nm、195nm、196nm、197nm、198nm、199、200nm、201nm、202nm、203nm、204nm、205nm、206nm、207nm、208nm、209、210nm、211nm、212nm、213nm、214nm、215nm、216nm、217nm、218nm、219、220nm、221nm、222nm、223nm、224nm、225nm、226nm、227nm、228nm、229、230nm、231nm、232nm、233nm、234nm、235nm、236nm、237nm、238nm、239、240nm、241nm、242nm、243nm、244nm、245nm、246nm、247nm、248nm、249、250nm、251nm、252nm、253nm、254nm、255nm、256nm、257nm、258nm、259、260nm、261nm、262nm、263nm、264nm、265nm、266nm、267nm、268nm、269、270nm、271nm、272nm、273nm、274nm、275nm、276nm、277nm、The procedure may include irradiation of the affected skin area with UVC light at a wavelength of 278 nm, 279 nm, or 280 nm. In some embodiments, the UVC light is approximately 20 mW / cm². 2 ~Approx. 1,000mW / cm 2 For example, approximately 30 mW / cm² 2 ~about 900mW / cm 2 , about 50mW / cm 2 ~about 850mW / cm 2 , about 100mW / cm 2 ~about 800mW / cm 2 , about 150mW / cm 2 ~about 750mW / cm 2 , about 200mW / cm 2 ~about 700mW / cm 2 , about 250mW / cm 2 ~about 650mW / cm 2 , about 300mW / cm 2 ~about 600mW / cm 2 , about 350mW / cm 2 ~about 550mW / cm 2 , about 400mW / cm 2 ~about 500mW / cm 2 , about 50mW / cm 2 , about 100mW / cm 2 , about 150mW / cm 2 , about 200mW / cm 2 , about 250mW / cm 2 , about 300mW / cm 2 , about 350mW / cm 2 , about 400mW / cm 2 , about 450mW / cm 2 , about 500mW / cm 2 , about 550mW / cm 2 , about 600mW / cm 2 , about 650mW / cm 2 , about 700mW / cm 2 , about 750mW / cm 2 , about 800mW / cm 2 , about 850mW / cm 2 , about 900mW / cm 2 , about 950mW / cm 2 , or approximately 1,000 mW / cm² 2It has a power density and can be continuous or pulsed illumination. In some embodiments where the illumination is pulsed, the pulse frequency is about 1 Hz to about 1,000 Hz, for example, about 5 Hz to about 950 Hz, about 10 Hz to about 900 Hz, about 25 Hz to about 850 Hz, about 50 Hz to about 800 Hz, about 100 Hz to about 750 Hz, about 150 Hz to about 700 Hz, about 200 Hz to about 650 Hz, about 250 Hz to about 600 Hz, about 300 Hz to about 550 Hz, about 350 Hz to about 525 Hz, about 400 to about 500 Hz, about 450 to about 475 Hz, about 2 Hz, about 5 Hz, about 10 Hz, approximately 25Hz, approximately 50Hz, approximately 100Hz, approximately 150Hz, approximately 200Hz, approximately 250Hz, approximately 300Hz, approximately 350Hz, approximately 400Hz, approximately 450Hz, approximately 500Hz, approximately 550Hz, approximately 600Hz, approximately 650Hz, approximately 700Hz, approximately 750Hz, approximately 800Hz, approximately 850Hz, approximately 900Hz, approximately 950Hz, approximately 1,000Hz, and the duty cycle can be 1-100% (e.g., 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%). In some embodiments, tissue sterilization may consist of multiple sterilization sessions and any combination of the procedures described above. In some embodiments, the sterilization device may be mounted on a slit lamp device. In further embodiments, the lighting may be controlled by a footplate. In some embodiments, a light guide can be introduced to a body part to deliver a therapeutic dose of UVC radiation. In some embodiments, a light guide can be introduced to an area inside the eye (e.g., vitreous humor, retina, choroid, macula, lens, ciliary muscle, optic nerve) to deliver a therapeutic dose and a germicidal dose of UVC radiation. In some embodiments, a proximity detection element is connected to the light guide and communicates with a microprocessor that controls the irradiation. In some embodiments, irradiation is initiated only when the output end of the light guide reaches a predetermined distance from the sterilization site. In some embodiments, once the sterilization cycle is complete, the UVC source stops and a signal generator notifies the operator to remove the device. In further embodiments, whenever the device is prematurely removed from the sterilization site, all light emission is paused until the predetermined distance is restored.In some embodiments, tissue sterilization may involve the use of an aperture control element. The aperture control element for tissue sterilization utilizes an aperture control element (e.g., a cone) with an aperture diameter of 10 mm to 50 mm (e.g., 25 mm) to enable wide-field illumination of the target tissue. In some embodiments, sterilization may involve an aperture control element that illuminates the tissue circumferentially (e.g., 360°).

[0106] Treatment of corneal ectasias such as keratoconus. In some embodiments, the apparatus described herein can be used as a therapeutic apparatus for treating corneal ectasias (e.g., keratoconus). In some embodiments, the apparatus is configured to deliver UVA light, and the configuration comprises a base component of the apparatus and a head component which may include a UVA light source, a proximity detection element, and a signal-generating element optical guide. Treatment of keratoconus involves crosslinking riboflavin with near-ultraviolet (UVA) light. The subject may first be administered a therapeutic dose of a photoactivator such as riboflavin into the eye. Suitable photoactivators include, but are not limited to, riboflavin, rose bengal, porphyrin-based photosensitizers, psoralen, quinone, anthracycline, anthracendione, xanthene, fluorescein, rhodamine, phthalein, cyanine, chalcogenapyryllium dyes, triarylmethane dyes, phenothiazine, phenoxazine, acridine, hypericin, nicotinamide adenine dinucleotide phosphate (NADPH), 5-aminolevulinic acid, ciprofloxacin, and quinine.In some embodiments, a sterilization session using the apparatus uses wavelengths from approximately 315nm to approximately 400nm (for example, approximately 316nm, 317nm, 318nm, 319nm, 320nm, 321nm, 322nm, 323nm, 324nm, 325nm, 326nm, 327nm, 328nm, 329nm, 330nm, 331nm, 332nm, 333nm, 334nm, 335nm, 336nm, 337nm, 338nm, 339nm, 340nm, 341nm, 342nm, 343nm, 344nm, 345nm, 346nm, 347nm, 348nm, 349nm, 350nm, 351nm, 352nm, 353nm, 354nm, 355nm, 356nm It may include irradiation of the affected tissue area with UVA light of 357nm, 358nm, 359nm, 360nm, 361nm, 362nm, 363nm, 364nm, 365nm, 366nm, 367nm, 368nm, 369nm, 370nm, 371nm, 372nm, 373nm, 374nm, 375nm, 376nm, 377nm, 378nm, 379nm, 380nm, 381nm, 382nm, 383nm, 384nm, 385nm, 386nm, 387nm, 388nm, 389nm, 390nm, 391nm, 392nm, 393nm, 394nm, 395nm, 396nm, 397nm, 398nm, 399nm, or 400nm. In some embodiments, the UVA light is approximately 0.5 mW / cm. 2 ~about 30mW / cm 2 (For example, approximately 1.0 mW / cm²) 2 , about 2.0mW / cm 2 , about 3.0mW / cm 2 , about 4.0mW / cm 2 , about 5.0mW / cm 2 , about 6.0mW / cm 2 , about 7.0mW / cm 2 , about 8.0mW / cm 2 , about 9.0mW / cm 2 , about 10mW / cm 2 , about 11mW / cm 2 , about 12mW / cm 2 , about 13mW / cm 2 , about 14mW / cm 2 , about 15mW / cm 2 , about 16mW / cm2 , about 17mW / cm 2 , about 18mW / cm 2 , about 19mW / cm 2 , about 20mW / cm 2 , about 21mW / cm 2 , about 22mW / cm 2 , about 23mW / cm 2 , about 24mW / cm 2 , about 25mW / cm 2 , about 26mW / cm 2 , about 27mW / cm 2 , about 28mW / cm 2 , about 29mW / cm 2 , or approximately 30 mW / cm² 2) has a power density and can be continuous or pulsed illumination. In some embodiments where the illumination is pulsed, the pulse frequency is about 20Hz to about 1,000Hz, for example, about 50Hz to about 950Hz, about 100Hz to about 900Hz, about 150Hz to about 850Hz, about 200Hz to about 800Hz, about 250Hz to about 750Hz, about 300Hz to about 700Hz, about 350Hz to about 650Hz, about 400Hz to about 600Hz, about 450Hz to about 550Hz, about 500Hz to about 525Hz, about 50Hz, about 100 Hz, approximately 150Hz, approximately 200Hz, approximately 250Hz, approximately 300Hz, approximately 350Hz, approximately 400Hz, approximately 450Hz, approximately 500Hz, approximately 550Hz, approximately 600Hz, approximately 650Hz, approximately 700Hz, approximately 750Hz, approximately 800Hz, approximately 850Hz, approximately 900Hz, approximately 950Hz, approximately 1,000Hz, and the duty cycle can be 1-100% (e.g., 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%). In some embodiments, treatment of dilatation such as keratoconus may consist of multiple sessions and any combination of the procedures described above. In some embodiments, the device may be mounted on a slit lamp device. In further embodiments, illumination may be controlled by a footplate. In some embodiments, a therapeutic dose of UVC radiation may be irradiated by using an optical guide. In some embodiments, a proximity detection element is connected to an optical guide and communicates with a microprocessor that controls the irradiation. In some embodiments, irradiation is initiated only when the output end of the optical guide reaches a predetermined distance from the administration site. In some embodiments, once the administration cycle is complete, the UVA source stops and a signal generator notifies the operator to remove the device. In further embodiments, whenever the device is removed prematurely from the administration site, all light emission is paused until the predetermined distance is restored.

[0107] <Sterilization of contact lenses, contact lens cases, eyeglasses, or eyeglass cases> In some embodiments, the apparatus described herein can be used as a sterilization apparatus for sterilizing contact lenses, contact lens cases, eyeglasses and / or eyeglass cases. In some embodiments, the sterilization apparatus is configured to sterilize contact lenses, contact lens cases, eyeglasses and / or eyeglass cases, and the configuration includes a base component of the apparatus and a head component which may include a UV source. In some embodiments, the apparatus described herein is configured to sterilize contact lens accessory items (e.g., contact lens socks, plungers, finger gloves). In some embodiments, a sterilization session using the apparatus is performed in the 100nm to 280nm range (e.g., 105nm to 275nm, 110nm to 270nm, 115nm to 265nm, 120nm to 260nm, 125nm to 255nm, 130nm to 250nm, 135nm to 245nm, 140nm to 240nm, 145nm to 235nm, 150nm to 230nm, 155nm to 225nm). , 160nm~220nm, 165nm~215nm, 170nm~210nm, 175nm~205nm, 180nm~200nm, 185nm~195nm, 101nm, 102nm, 103 nm, 104nm, 105nm, 106nm, 107nm, 108nm, 109, 110nm, 111nm, 112nm, 113nm, 114nm, 115nm, 116nm, 117nm, 118n m, 119, 120nm, 121nm, 122nm, 123nm, 124nm, 125nm, 126nm, 127nm, 128nm, 129, 130nm, 131nm, 132nm, 133nm, 134nm, 135nm, 136nm, 137nm, 138nm, 139, 140nm, 141nm, 142nm, 143nm, 144nm, 145nm, 146nm, 147nm, 148nm, 1 49, 150nm, 151nm, 152nm, 153nm, 154nm, 155nm, 156nm, 157nm, 158nm, 159, 160nm, 161nm, 162nm, 163nm, 164 nm, 165nm, 166nm, 167nm, 168nm, 169, 170nm, 171nm, 172nm, 173nm, 174nm, 175nm, 176nm, 177nm, 178nm, 179,180nm, 181nm, 182nm, 183nm, 184nm, 185nm, 186nm, 187nm, 188nm, 189, 190nm, 191nm, 192nm, 193nm , 194nm, 195nm, 196nm, 197nm, 198nm, 199, 200nm, 201nm, 202nm, 203nm, 204nm, 205nm, 206nm, 207n m, 208nm, 209, 210nm, 211nm, 212nm, 213nm, 214nm, 215nm, 216nm, 217nm, 218nm, 219, 220nm, 221nm , 222nm, 223nm, 224nm, 225nm, 226nm, 227nm, 228nm, 229, 230nm, 231nm, 232nm, 233nm, 234nm, 235nm , 236nm, 237nm, 238nm, 239, 240nm, 241nm, 242nm, 243nm, 244nm, 245nm, 246nm, 247nm, 248nm, 249, 250nm, 251nm, 252nm, 253nm, 254nm, 255nm, 256nm, 257nm, 258nm, 259, 260nm, 261nm, 262nm, 263nm, The system may include irradiation of contact lenses, contact lens cases, eyeglasses and / or eyeglass cases with UVC light of wavelengths (264nm, 265nm, 266nm, 267nm, 268nm, 269, 270nm, 271nm, 272nm, 273nm, 274nm, 275nm, 276nm, 277nm, 278nm, 279, or 280nm). In some embodiments, the UVC light is approximately 20 mJ / cm. 2 ~Approx. 5000mJ / cm 2 For example, approximately 50 mJ / cm² 2 ~Approx. 4500mJ / cm 2 , about 100mJ / cm 2 ~About 4000mJ / cm 2 , about 200mJ / cm 2 ~About 4000mJ / cm 2 , about 300mJ / cm 2 ~Approx. 3500mJ / cm 2 , about 500mJ / cm 2 ~Approx. 3000mJ / cm 2 , about 1,000mJ / cm 2 ~Approx. 2500mJ / cm 2Approximately 1500 mJ / cm 2 ~approximately 2000 mJ / cm 2 Approximately 100 mJ / cm 2 Approximately 200 mJ / cm 2 Approximately 300 mJ / cm 2 Approximately 400 mJ / cm 2 Approximately 500 mJ / cm 2 Approximately 600 mJ / cm 2 Approximately 700 mJ / cm 2 Approximately 800 mJ / cm 2 Approximately 900 mJ / cm 2 Approximately 1,000 mJ / cm 2 Approximately 1500 mJ / cm 2 Approximately 2000 mJ / cm 2 Approximately 2500 mJ / cm 2 Approximately 3000 mJ / cm 2 Approximately 3500 mJ / cm 2 Approximately 4000 mJ / cm 2 Approximately 4500 mJ / cm 2 Approximately 5000 mJ / cm 2It has a power density and can be continuous or pulsed illumination. In some embodiments where the illumination is pulsed, the pulse frequency is about 20 Hz to about 1,000 Hz, for example, about 50 Hz to about 950 Hz, about 100 Hz to about 900 Hz, about 150 Hz to about 850 Hz, about 200 Hz to about 800 Hz, about 250 Hz to about 750 Hz, about 300 Hz to about 700 Hz, about 350 Hz to about 650 Hz, about 400 Hz to about 600 Hz, about 450 Hz to about 550 Hz, about 500 Hz to about 525 Hz, about 50 Hz, about 100 Hz , approximately 150Hz, approximately 200Hz, approximately 250Hz, approximately 300Hz, approximately 350Hz, approximately 400Hz, approximately 450Hz, approximately 500Hz, approximately 550Hz, approximately 600Hz, approximately 650Hz, approximately 700Hz, approximately 750Hz, approximately 800Hz, approximately 850Hz, approximately 900Hz, approximately 950Hz, approximately 1,000Hz, Hz, the duty cycle can be 1-100% (e.g., 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%). In some embodiments, sterilization may consist of multiple sterilization sessions (e.g., daily, weekly, monthly, yearly) and any combination of the procedures described above. In some embodiments, the sterilization device may be connected to a contact lens case. In some embodiments, the sterilization device may be connected to an eyeglass case. In further embodiments, sterilization is performed in combination with ultrasound emitted by a contact lens case or eyeglass case.

[0108] <Examples> The following examples are provided to explain how the compositions and methods described herein may be used, manufactured, and evaluated, and are intended purely to illustrate the present invention, and not to limit the scope of what the inventors consider to be their invention.

[0109] <Example 1. Use of a therapeutic device for treating blepharitis and / or meibomian gland disease (MGD)> The therapeutic device described herein can be used to treat blepharitis and / or meibomian gland disease (MGD). An ophthalmologist uses the device to treat blepharitis and / or meibomian gland disease (MGD) (Figures 1-8). The head component is equipped with a UV source and optionally one or more of the following: an infrared (IR) light source, a heat source, a powerful pulsed light source, and an ultrasonic source (Figures 1-8). The ophthalmologist brings the head component close to the lower eyelid of the patient's left eye by pressing the control button on the base component. The ophthalmologist initiates treatment by pressing the control button on the base component of the device, in addition to bringing the head component into contact with the affected eyelid. The therapeutic dose of UVC light at a wavelength of 265 nm is 2 mW / cm². 2 At this output, it is emitted from the distal end of the head component for 30 seconds. Following the UVC irradiation of the eyelids, the ophthalmologist presses the control button again to select ultrasound and heat emitted from the distal end of the head component. 0.7 W / cm 2 The 3MHz frequency therapeutic ultrasound is transmitted to the eyelid along with simultaneous heating by a heating element located at the distal end of the head component, raising the temperature of the meibomian glands to approximately 40°C, thereby softening and removing the oily particles clogging the meibomian glands in the affected eyelid. Next, the ophthalmologist activates the eyelid irradiation by pressing the control button on the base component for the third time, irradiating the eyelid with 2.0μm wavelength infrared light for 12 minutes, with a 30-second downtime between treatment irradiations. The treatment is repeated monthly, for a total of four treatment sessions.

[0110] <Example 2. Use of a treatment device for treating eye cancer> The therapeutic device described herein can be used to treat ocular cancer. An oncologist uses the device to treat ocular melanoma (Figures 9-15). The head component comprises a UV source, a proximity detection element, and an imaging module (Figures 9-15). The oncologist activates the proximity detection element by pressing the power button on the base component and brings the device closer to the affected eye. When a predetermined distance is reached between the UVC light source located at the distal end of the head component and the melanoma site, the proximity detection element signals the oncologist. The proximity detection element activates a green light visible to the oncologist when the device is at the predetermined distance, and a red light visible to the oncologist when the device is outside the predetermined distance. Holding the therapeutic device at the predetermined distance from the tumor site, the oncologist activates the UVC light located at the distal end of the head component to provide a 10-minute UVC light treatment session with a wavelength of 265 nm at a pulse frequency of 5 Hz. UVC therapy is administered 1 to 10 times with a 1-week rest period in between.

[0111] <Example 3. Use of a treatment device to reduce the viral load in the oral cavity> The treatment device described herein can be used to reduce the viral load in the mouth of patients infected with SARS-CoV-2. The dentist uses the device to sterilize the oral cavity. The head component is equipped with a UV source, a UVC optical fiber, a proximity detection element, and a signal generation element. The dentist transmits UVC light into the mouth by attaching the input end of the optical fiber to the distal end of the UVC light source in the head component. The dentist then presses the power button on the base component of the device. The optical fiber is equipped with a proximity detection element that keeps the UVC light off until a predetermined sterilization distance is reached between the output end of the optical fiber and the treatment site. When the output end of the optical fiber reaches the predetermined distance from the treatment site, the proximity detection element activates a green light to inform the dentist that the predetermined distance has been reached. Holding the optical fiber at the predetermined distance from the treatment site, the dentist activates the UVC light located at the distal end of the head component, emitting 20 mW / cm² for 30 seconds at a wavelength of 265 nm and a pulse frequency of 20 Hz. 2The output provides UVC light therapy sessions. UVC therapy will be repeated as needed for future dental treatments.

[0112] <Example 4. Use of a treatment device for treating keratoconus> The therapeutic device described herein can be used to treat keratoconus. Treatment of keratoconus involves crosslinking of riboflavin with near-ultraviolet (UVA) light. The ophthalmologist first administers a riboflavin therapeutic solution to the patient's affected eye. The ophthalmologist uses the device to treat keratoconus (Figures 16 and 17). The head component is equipped with a UVA light source, a proximity detection element, and a signal generation element (Figures 16 and 17). The ophthalmologist activates the proximity detection element by pressing the power button on the base component and brings the device close to the affected cornea. When a predetermined distance is reached between the UVA light source, located at the distal end of the head component, and the affected cornea, the proximity detection element sends a signal to the ophthalmologist. The proximity detection element activates a green light visible to the ophthalmologist when the device is at the predetermined distance, and activates a red light visible to the ophthalmologist when the device is outside the predetermined distance. The ophthalmologist holds the treatment device at a predetermined distance from the affected cornea and activates the UVA light located at the distal end of the head component, thereby controlling the dose of 365nm wavelength UVA light at a power of 9mW / cm². 2 I will deliver the message for 10 minutes.

[0113] <Example 5. Use of a treatment device for sterilizing contact lenses> The treatment device described herein can be used to sterilize contact lenses. The operator using the device for sterilizing contact lenses attaches the head component to the base component of the sterilizer (Figures 18-22). The head component is equipped with a UV source and an attachment clip that connects the distal end of the head component to the contact lens storage case. The contact lens case is also equipped with an ultrasonic source. The operator attaches the sterilizer, which includes the base component and the contact lens sterilization head component, to the contact lens case. The operator then presses the power button on the base component of the sterilizer to activate UVC irradiation at a wavelength of 220 nm and 20 mW / cm². 2 A predetermined sterilization program is activated, combining UVC power with 3MHz ultrasound at a pulse frequency of 5Hz for 300 seconds. UVC therapy is repeated daily.

[0114] <Example 6. Use of a treatment device for sterilizing eyeglasses> The treatment device described herein can be used to sterilize eyeglasses. The operator attaches the head component to the base component of the sterilizer by using the head component for sterilizing eyeglasses. The head component is equipped with a UV source and an attachment clip that connects the distal end of the head component to the eyeglass storage case. The eyeglass case is also equipped with an ultrasonic source. The operator attaches the sterilizer, which includes the base component and the eyeglass sterilization head component, to the eyeglass case. The operator then presses the power button on the base component of the sterilizer to activate UVC irradiation at a wavelength of 265 nm and 20 mW / cm². 2 A predetermined sterilization program is activated, combining UVC power with 300 seconds of 3MHz ultrasound. UVC and ultrasound therapy are repeated after each use of the glasses.

[0115] <Example 7. Use of a treatment device for sterilizing the eye and eyelids> The treatment device described herein can be used to reduce the viral load on the eyes and eyelids of patients infected with SARS-CoV-2 before surgical procedures. The ophthalmologist uses the device to sterilize the eyes and eyelids. The head component is equipped with a UV source, an aperture control component, a proximity detection element, and a signal generation element. The ophthalmologist delivers UVC light to the eyelids by attaching the UVC LED delivery head to the head component and attaching a 50 mm diameter aperture control component to the distal end of the UVC LED. Next, the ophthalmologist presses the power button on the base component of the device. The head component includes a proximity detection element that keeps the UVC light off until a predetermined sterilization distance is reached between the output end of the aperture control component and the treatment site. When the output end of the aperture control component reaches the predetermined distance from the treatment site, the proximity detection element activates a green light to inform the ophthalmologist that the predetermined distance has been achieved. The ophthalmologist maintains the aperture control component at a predetermined distance from the treatment site and activates the UVC light positioned at the distal end of the head component to deliver a 30-second UVC light treatment session at a wavelength of 265 nm and a pulse frequency of 20 Hz. The UVC therapy is repeated only before the commencement of any subsequent surgical procedure.

[0116] <Example 8. Use of a treatment device for sterilizing the nasal cavity> The therapeutic device described herein can be used to reduce the viral load in the nose of patients infected with SARS-CoV-2. An otolaryngologist selects the device for sterilizing the nasal cavity. The head component is equipped with a UV source, a UVC optical fiber, an aperture control component, a proximity detection element, and a signal generation element. The otolaryngologist delivers UVC light into the nose by attaching the input end of the optical fiber to the distal end of the UVC light source of the head component and to the 360-degree irradiation aperture control component. The otolaryngologist then presses the power button on the base component of the device. The optical fiber is equipped with a proximity detection element that keeps the UVC light off until a predetermined sterilization distance is reached between the output end of the optical fiber and the treatment site. When the output end of the optical fiber reaches the predetermined distance from the treatment site, the proximity detection element activates a green light to inform the otolaryngologist that the distance has been reached. By holding the optical fiber at a predetermined distance from the treatment site, the otolaryngologist activates the UVC light positioned at the distal end of the head component to provide a continuous UVC light treatment session with a wavelength of 265 nm.

[0117] <Example 9. Use of a Therapeutic Multi-Head Device> The therapeutic device described herein can be used to treat different medical indications. Its design, comprising a base component and multiple treatment heads configured to treat various indications, allows healthcare providers to exchange treatment heads between different patients. The ophthalmologist selects a head component to treat the first patient's blepharitis. The head component is equipped with a UV source, an infrared (IR) light source, a heat source, and an ultrasonic source. The ophthalmologist brings the head component close to the lower eyelid of the patient's left eye by pressing the power button on the base component. The ophthalmologist initiates treatment by pressing the control button on the base component of the device, in addition to bringing the head component into contact with the affected eyelid. The therapeutic dose of UVC light at a wavelength of 265 nm is 10 mW / cm². 2At this output, it is emitted from the distal end of the head component for 30 seconds. Following the UVC irradiation of the eyelids, the ophthalmologist presses the control button again to select ultrasound and heat emitted from the distal end of the head component. 0.7 W / cm 2 The 3MHz frequency therapeutic dose of ultrasound is delivered to the eyelid along with simultaneous heating by a heating element, raising the eyelid temperature to 40°C. This softens the oily particles clogging the meibomian glands of the affected eyelid, facilitating their removal. The treatment is repeated monthly and supplemented by manual or automated compression of the glands. Next, the ophthalmologist examines the second patient and selects a head to reduce the viral load on the eyelid by sterilizing the eyelid. The ophthalmologist removes the head for blepharitis treatment from the base component by pressing the release button on the base component and replaces it with a head and optical fiber for the sterile application. The ophthalmologist uses an attachment adapter element to secure the base component to a slit lamp, allowing for manual control of the optical fiber. Next, the ophthalmologist presses the power button on the base component of the device. The optical fiber is equipped with a proximity detection element that keeps the UVC light off until a predetermined sterilization distance is reached between the output end of the optical fiber and the treatment site. When the output end of the optical fiber reaches a predetermined distance from the treatment site, the proximity detection element activates a green light to inform the dentist that the predetermined distance has been reached. While maintaining the optical fiber at the predetermined distance from the treatment site, the ophthalmologist activates UVC light located at the distal end of the head component, with a wavelength of 265 nm and a power of 20 mW / cm². 2 It provides a continuous UVC light treatment session for 30 seconds at this output.

[0118] <Example 10. Use of a treatment device for treating gastric ulcers> The treatment device described herein can be used to reduce the bacterial load in the gastrointestinal tract of patients suffering from H. pylori (Helicobacter pylori) ulcers. The gastroenterologist selects a head component for sterilizing the gastrointestinal lumen and attaches the head component to the base component of the treatment device. The head component is equipped with a far ultraviolet (UVC) light source, a UVC optical fiber, a proximity detection element, and a signal generation element. The gastroenterologist delivers UVC light into the gastrointestinal lumen by attaching the input end of the optical fiber to the distal end of the UVC light source on the head component (this may be attached to or integrated into an endoscope). The gastroenterologist then presses the power button on the base component of the device. The optical fiber is equipped with a proximity detection element that keeps the UVC light off until a predetermined sterilization distance is reached between the output end of the optical fiber and the treatment site. When the output end of the optical fiber reaches the predetermined distance from the treatment site, the proximity detection element activates a green light to inform the gastroenterologist that the distance has been reached. The optical fiber is held at a predetermined distance from the treatment site, and the gastroenterologist activates the UVC light located at the distal end of the head component to deliver a 30-second UVC light treatment session at a wavelength of 265 nm and a pulse frequency of 5 Hz. The UVC therapy is repeated up to 10 times with a 300-second rest period in between.

[0119] <Example 11. Use of a treatment device for treating gingivitis> The treatment device described herein can be used to treat gingivitis in a patient's mouth. A dental hygienist uses the device to sterilize the oral cavity. The head component is attached to a light guide equipped with a UVC LED at the distal end of the light guide (Figures 28A, 28B, 28C, and 28D), and the device is also equipped with a proximity detection element and a signal generation element. The dental hygienist transmits UVC light into the mouth by attaching the proximal end of the light guide to the head component. Next, the dental hygienist presses the power button on the base component of the device. The light guide is equipped with a proximity detection element that keeps the UVC light off until a predetermined treatment distance is reached between the output end of the light guide and the treatment site. When the output end of the light guide reaches the predetermined distance from the treatment site, the proximity detection element activates a green light to inform the dental hygienist that the predetermined distance has been reached. The dental hygienist holds the device at a predetermined distance from the treatment site and activates the UVC LED light located at the distal end of the light guide, emitting 20 mW / cm² of light for 30 seconds at a wavelength of 265 nm and a pulse frequency of 20 Hz. 2 The device provides UVC light therapy sessions at its output. UVC therapy is repeated as needed for future gingivitis treatment.

[0120] <Example 12. Use of a treatment device for treating periodontitis and dental infections> The treatment device described herein can be used to treat periodontitis and dental infections in a patient's mouth. A dental professional (e.g., a dentist or dental hygienist) uses the device to sterilize the oral cavity and cavities. The head component is attached to a light guide equipped with a UVC LED at the distal end of the light guide (Figures 28A, 28B, 28C, and 28D), and the device is also equipped with a proximity detection element and a signal generation element. The dental hygienist transmits UVC light to the periodontal area and infected area of ​​the tooth of interest by attaching the proximal end of the light guide to the head component. The dental hygienist then presses the power button on the base component of the device. The light guide is equipped with a proximity detection element that keeps the UVC light off until a predetermined treatment distance is reached between the output end of the light guide and the treatment site. When the output end of the light guide reaches the predetermined distance from the treatment site, the proximity detection element activates a green light to inform the dental hygienist that the predetermined distance has been reached. The dental hygienist holds the device at a predetermined distance from the treatment site and activates the UVC LED light located at the distal end of the light guide, emitting a pulse of 20 Hz for 30 seconds at 20 mW / cm². 2 The device provides a 265nm UVC light treatment session at its output. UVC therapy will be repeated as needed to treat future periodontitis and dental infections.

[0121] <Example 13. Use of a treatment device for treating cancer> The therapeutic device described herein can be used to treat cancer. A breast surgeon uses the device to treat breast cancer (Figures 28A-28D). The head component is mounted on an optical guide equipped with a UVC LED at the distal end of the optical guide (Figures 28A-28D), and the device is also equipped with a proximity detection element and a signal generation element. The oncologist activates the proximity detection element by pressing the power button on the base component and pulls the device closer to the tumor site. When a predetermined distance is reached between the UVC light source located at the distal end of the head component and the tumor site, the proximity detection element sends a signal to the oncologist. The proximity detection element activates a green light visible to the oncologist when the device is at the predetermined distance, and activates a red light visible to the oncologist when the device is outside the predetermined distance. Holding the therapeutic device at the predetermined distance from the tumor site, the oncologist activates the UVC light located at the distal end of the head component to provide a 10-minute UVC light treatment session with a wavelength of 265 nm at a pulse frequency of 5 Hz. UVC therapy is administered 1 to 10 times with a one-week rest period in between.

[0122] <Other Embodiments> While the present invention is described in conjunction with its specific embodiments, it is intended that the present invention is subject to further modifications, and that this application generally covers any variations, uses, or adaptations of the present invention in accordance with the principles of the invention, and that any departures from the invention that become known or are customarily practiced in the art to which the invention relates, and that are applicable to the essential features described above and subject to the claims. Other embodiments are found in the claims.

Claims

1. A device as a therapeutic apparatus comprising a base component and a head component, The head component comprises a distal portion and a proximal portion, The distal portion of the head component is configured to contact the eyelid of the target, The proximal portion of the head component is configured to be attached to the base component, The distal portion of the head component is configured to transmit therapeutic dose energy from a plurality of energy sources, including a far-ultraviolet (UVC) radiation source, an infrared (IR) radiation source, and an ultrasonic source. The plurality of energy sources are configured to transmit the therapeutic dose of energy to the target eyelid at a predetermined output when the distal portion of the head component comes into contact with the eyelid. Device.

2. UVC radiation has wavelengths ranging from approximately 100 nm to approximately 280 nm. The apparatus according to claim 1.

3. UVC radiation is approximately 20 mW / cm². ２ ~Approx. 1,000mW / cm ２ Having a radiant intensity, The apparatus according to claim 1 or 2.

4. IR emission has peak wavelengths ranging from approximately 750 nm to approximately 1,000,000 nm. The apparatus according to any one of claims 1 to 3.

5. IR radiation is approximately 20 mW / cm². ２ ~1,000mW / cm ２ Having a radiant intensity, The apparatus according to any one of claims 1 to 4.

6. Ultrasound has frequencies ranging from approximately 1 MHz to approximately 10 MHz. The apparatus according to any one of claims 1 to 5.

7. The apparatus further includes a temperature sensor and / or a heat source. The apparatus according to any one of claims 1 to 6.

8. The apparatus further comprises a microwave radiation source and / or a powerful pulsed light source. The apparatus according to any one of claims 1 to 7.

9. The device further includes a contact sensor. The apparatus according to any one of claims 1 to 8.

10. A device as a therapeutic apparatus comprising a base component and a head component, The head component comprises a distal portion and a proximal portion, The distal portion of the head component is configured to transmit a therapeutic dose of UVC radiation from a UVC radiation source to the target eye. The proximal portion of the head component is configured to be attached to the base component, The aforementioned device further, A proximity determination element configured to detect a predetermined distance between the UVC radiation source and the treatment site of the eye, A signal generating element configured to generate a signal when the proximity determination element detects the predetermined distance, wherein the signal is configured to transmit the therapeutic dose of UVC radiation to the target eye at a predetermined output by activating the UVC radiation source, A device equipped with the following features.

11. The apparatus further includes an optical guide having a proximal portion and a distal portion. The proximal portion of the optical guide is configured to be attached to the distal portion of the head component, The distal portion of the optical guide is configured to transmit the UVC radiation of the therapeutic dose. The apparatus according to claim 10.

12. The aforementioned therapeutic dose of UVC is configured to be transmitted to the eye of the subject via a vitrectomy element. The apparatus according to claim 10.

13. The UVC radiation source is inserted into the vitrectomy element and configured to directly deliver the therapeutic dose of UVC radiation to the eye of the target. The apparatus according to claim 12.

14. The UVC radiation source is configured to deliver the therapeutic dose of UVC radiation to the internal region of the eye of the target through an optical guide that is inserted into the hollow region of the vitrectomy element and enters the internal region of the eye of the target. The apparatus according to claim 12.

15. The aforementioned device further includes an eye stabilizing element. The aforementioned eye stabilizing element is The proximal end is configured to be attached to the distal portion of the head component, The distal end is configured to be stabilized by contact with the eye, It is equipped with The apparatus according to any one of claims 10 to 14.

16. The eye stabilizing element is conical in shape, having a first diameter at its proximal end and a second diameter at its distal end. The apparatus according to claim 15.

17. The distal end of the eye stabilizing element comprises a plurality of teeth configured to fix the eye of the target, The apparatus according to claim 15.

18. The eye stabilizing element is substantially hollow and provides a volume through which the therapeutic dose of UVC radiation from the head component can be transferred to the treatment area of ​​the eye of the target. The apparatus according to any one of claims 15 to 17.

19. The apparatus further comprises components used to maintain the eyelids of the target in an open state. The apparatus according to any one of claims 15 to 18.

20. A sterilization device comprising a base component and a head component, The head component comprises a distal portion and a proximal portion, The distal portion of the head component is configured to transmit a germicidal dose of UVC radiation from the UVC radiation source to the target. The proximal portion of the head component is configured to be attached to the base component, The aforementioned device further, An optical guide having a proximal portion and a distal portion, wherein the proximal portion of the optical guide is configured to be attached to the distal portion of the head component, and the distal portion of the optical guide is configured to transmit UVC radiation of the germicidal dose, A proximity determination element configured to detect a predetermined distance between the distal portion of the optical guide and the treatment site of the target, A signal generating element configured to generate a signal when the proximity determination element detects the predetermined distance, wherein the signal is configured to transmit UVC radiation of the germicidal dose at a predetermined output through the optical guide by activating the UVC radiation source, A device equipped with the following features.

21. The head component includes an aperture control element configured to adjust the dose of UVC radiation. The apparatus according to any one of claims 1 to 20.

22. The opening control element comprises one or more removable cones. The apparatus according to claim 21.

23. The distal portion of the optical guide comprises a substantially hollow tube configured to deliver a therapeutic dose of UVC to the vitreous cavity region, retinal region, choroidal region, macular region, intraocular lens region, ciliary muscle region, optic nerve region, damaged area, or the area of ​​the eye affected by the foreign body. The apparatus according to any one of claims 20 to 22.

24. A device as a therapeutic apparatus comprising a base component and a head component, The head component comprises a distal portion and a proximal portion, The distal portion of the head component is configured to transmit a therapeutic dose of near-ultraviolet (UVA) radiation from a UVA radiation source to the target eye. The proximal portion of the head component is configured to be attached to the base component, The aforementioned device further, A proximity determination element configured to detect a predetermined distance between the UVA radiation source and the treatment site of the target, A signal generating element configured to generate a signal when the proximity determination element detects the predetermined distance, wherein the signal is configured to transmit the therapeutic dose of UVA radiation to the target eye at a predetermined output by activating the UVA radiation source, A device equipped with the following features.

25. The aforementioned UVA radiation has wavelengths ranging from approximately 315 nm to approximately 400 nm. The apparatus according to claim 24.

26. The aforementioned UVA emission is approximately 0.5 mW / cm². ２ ~Approx. 100mW / cm ２ Having a radiant intensity, The apparatus according to claim 24 or 25.

27. The apparatus further includes an imaging module configured to display an image of the treatment site. The apparatus according to any one of claims 1 to 26.

28. The proximity detection element comprises two or more lasers. The apparatus according to any one of claims 24 to 27.

29. The proximity detection element is configured to activate a signal generation element when the two or more lasers converge. The apparatus according to claim 28.

30. The signal generating element is configured to provide auditory, visual, or tactile signals. The apparatus according to any one of claims 24 to 29.

31. A device comprising a base component and a head component, The head component comprises a distal portion and a proximal portion, The distal portion of the head component is configured to transmit a certain dose of UVC radiation from a UVC radiation source to a contact lens or eyeglasses. The proximal portion of the head component is configured to be attached to the base component, The device further includes a contact lens case or eyeglasses case equipped with an ultrasonic source. The contact lens case or eyeglass case is attached to the distal portion of the head component and is configured to transmit a certain dose of ultrasound. Device.

32. A system for transmitting multiple energy sources to tissue sites, The aforementioned system comprises a base component, The aforementioned base component comprises a proximal portion and a distal portion, The distal portion is (a) First head equipped with a UVC radiation source, (b) Second head equipped with an IR radiation source, (c) Third head equipped with an ultrasonic source, (d) A fourth head equipped with a UVA radiation source, (e) A fifth head equipped with a UVC radiation source, an IR radiation source, and an ultrasonic source, (f) A sixth head equipped with a microwave radiation source and a powerful pulsed light source, It is configured to mate to one of several interchangeable heads selected from two or more of the following: system.

33. The first head further, A proximity determination element configured to detect a predetermined distance between the energy source and the administration site, A signal generation element configured to generate a signal when the proximity determination element detects the predetermined distance, An aperture control module for adjusting the energy dose, an optical guide, and an imaging module, It has one or more of the following: The system according to claim 32.

34. A method for treating blepharitis or meibomian gland disease (MGD), wherein the method is: A step of providing the apparatus according to any one of claims 1 to 9, A step to enable the distal portion of the head component to contact the eyelid, The process involves administering the energy of the aforementioned therapeutic dose to the eyelid from multiple energy sources, A method that includes [the following features].

35. The method further comprises a step of transferring heat. The method according to claim 34.

36. A method for treating an eye infection or a cancer selected from eyelid cancer, eye cancer, or orbital cancer, or adnexal cancer, wherein the method is (a) Providing the apparatus according to any one of claims 10 to 19, and the step of arranging the apparatus near the treatment site, (b) A step of detecting the predetermined distance using the proximity determination element, (c) A step of generating the signal using the signal generating element in order to activate the UVC radiation source, (d) The step of administering the therapeutic dose of UVC radiation to the treatment site, A method that includes [the following features].

37. The aforementioned eyelid cancer or eye cancer is intraocular melanoma, retinoblastoma, uveal melanoma, or conjunctival melanoma, or The aforementioned eye infection is endophthalmitis. The method according to claim 36.

38. A method for sterilizing target tissue, wherein the method is (a) Providing the apparatus according to any one of claims 20 to 23, and further comprising the step of arranging the optical guide near the treatment site, (b) A step of detecting the predetermined distance using the proximity determination element, (c) A step of generating the signal using the signal generating element in order to activate the UVC radiation source, (d) A step of administering a therapeutic dose of UVC radiation to the treatment site of the target tissue via the optical guide, A method that includes [the following features].

39. The tissues are selected from the eyes, nasal cavity, oral cavity, skin tissue, and tubular lumens. The method according to claim 38.

40. The aforementioned subjects have or are suspected of having ulcers, human immunodeficiency virus infection, herpesvirus infection, or human papillomavirus infection. The method according to claim 38 or 39.

41. A method for treating corneal ectasia in a subject, wherein the method is (a) Providing an apparatus according to any one of claims 24 to 29, the step of arranging the apparatus near the treatment site, wherein the target is administered a certain dose of a photoactivator to the treatment site, (b) A step of detecting the predetermined distance using the proximity determination element, (c) A step of generating the signal using the signal generating element in order to activate the UVA radiation source, (d) The step of administering the UVA radiation of the therapeutic dose to the treatment site of the eye, A method that includes [the following features].

42. The aforementioned photoactivator is riboflavin, rose bengal, porphyrin-based photosensitizers, psoralen, quinone, anthracycline, anthracendione, xanthene, fluorescein, rhodamine, phthalein, cyanine, chalcogenapyryllium dye, triarylmethane dye, phenothiazine, phenoxazine, acridine, hypericin, nicotinamide adenine dinucleotide phosphate (NADPH), 5-aminolevulinic acid, ciprofloxacin, or quinine. The method according to claim 41.

43. A method for sterilizing contact lenses or eyeglasses, wherein the method is: A step of providing the apparatus described in claim 31, The process of placing the aforementioned contact lenses or eyeglasses into a case, The process of administering the UVC radiation source and ultrasonic source to the contact lens or eyeglasses, A method that includes [the following features].

44. A contact lens having a proximal end and a distal end, The aforementioned contact lens is configured to direct the therapeutic dose of UVC radiation towards the target eye. Contact lenses.

45. The aforementioned contact lens is equipped with a UVC radiation source. The contact lens according to claim 44.

46. The UVC radiation source is equipped with a surface-mount (SMD) LED. The contact lens according to claim 45.

47. Multiple LEDs, It is configured to be attached to the aforementioned contact lens, It is configured to be incorporated into the aforementioned contact lens, or The contact lens is configured to focus the light through the aforementioned contact lens. The contact lens according to claim 46.

48. A method for treating an eye infection, wherein the method is (a) Providing a contact lens according to claim 44, and a step of placing the contact lens on an infected area of ​​the eye, (b) The step of administering the therapeutic dose of UVC radiation to the eyelid or the treatment site of the eye, A method that includes [the following features].

49. A method for treating a wound in a subject, wherein the method is (a) A step of providing the apparatus according to claim 10 or 11, (b) The step of administering the therapeutic dose of UVC radiation to the wound, A method that includes [the following features].

50. A method for treating cancer, wherein the method is (a) Providing the apparatus according to any one of claims 10 to 19, and the step of arranging the apparatus near the treatment site, (b) A step of detecting the predetermined distance using the proximity determination element, (c) A step of generating the signal using the signal generating element in order to activate the UVC radiation source, (d) The step of administering the therapeutic dose of UVC radiation to the treatment site, A method that includes [the following features].

Images