Compositions and methods for enhancing immune activity
JP2026094293APending Publication Date: 2026-06-09KUMQUAT BIOSCIENCES INC
Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- KUMQUAT BIOSCIENCES INC
- Filing Date
- 2026-02-27
- Publication Date
- 2026-06-09
AI Technical Summary
Benefits of technology
【0066】 本発明の新規の特徴を、特に、添付される特許請求の範囲において示す。本発明の特徴および利点のより良い理解は、本発明の原理が利用される実例となる実施形態を示す以下の詳細な説明に対する参照によって得られ、添付する図面は以下の通りである。
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Abstract
This invention provides compositions and methods for enhancing immunity, which are particularly useful for strengthening the immune response of lymphocytes. [Solution] A method for increasing the efficacy of cell therapy or reducing side effects for a subject that requires increasing the efficacy of cell therapy or reducing side effects, comprising the step of administering to the subject a pharmaceutical composition comprising cells comprising (i) a chimeric T cell receptor (TCR) sequence encoding a T cell receptor fusion protein (TFP) and / or (ii) a CAR sequence encoding a chimeric antigen receptor (CAR), wherein each of the TFP and CAR exhibits specific binding to an antigen, and the cells are exposed to a small molecule PTPN2 inhibitor.
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