Ceramide-containing plate-shaped vesicle dispersion and cosmetics containing the same

Abstract

The objective is to provide a ceramide-containing plate-shaped vesicle dispersion that does not precipitate ceramide crystals and has excellent temporal stability, and furthermore, a ceramide-containing plate-shaped vesicle dispersion that does not precipitate ceramide crystals and has excellent temporal stability, and also does not precipitate ceramide crystals even in the state of a coating film, and a cosmetic composition containing the ceramide-containing plate-shaped vesicle dispersion. [Solution] A ceramide-containing plate-shaped vesicle dispersion is provided, characterized in that it contains (A) ceramide, (B) one or more selected from sucrose palmitate and sucrose stearate having an HLB value of 11 or higher, (C) a polyhydric alcohol, and (D) water, wherein the content of (B) is 8% by weight or less, the weight ratio (B) / (A) is 2 or more, the weight ratio (C) / (B) is 0.5 or more, and (E) if it contains an oil that is liquid at 25°C, the weight ratio (E) / (B) is 0.25 or less, and the average particle diameter is 200 nm or less. A cosmetic composition is provided, characterized in that it contains the plate-shaped vesicle dispersion.

Description

[Technical Field] 【0001】 The present invention relates to a ceramide-containing plate-shaped vesicle dispersion that does not precipitate ceramide crystals and has excellent temporal stability, and further to a ceramide-containing plate-shaped vesicle dispersion that does not precipitate ceramide crystals and has excellent temporal stability, and also to a ceramide-containing plate-shaped vesicle dispersion in which ceramide crystals do not precipitate even in the state of a coating film, and to a cosmetic composition containing the ceramide-containing plate-shaped vesicle dispersion. [Background technology] 【0002】 Ceramides, present in the stratum corneum of the skin, constitute intercellular lipids and are attracting attention as essential components for the skin's barrier function. Therefore, their application as high-performance moisturizers is promising. However, ceramides have the challenge of low solubility in cosmetic bases. This makes it difficult to incorporate them in large quantities into cosmetics, and even if they can be incorporated, crystals tend to precipitate over time, impairing the feel and appearance of the cosmetic and reducing its market value. 【0003】 To address this challenge, a technique for stably incorporating ceramides into topical skin preparations such as cosmetics is known: the use of vesicle dispersions. Vesicles are also used as drug delivery systems (DDS), and by encapsulating ceramides in vesicles, it is possible not only to suppress crystallization but also to improve absorption into the skin. 【0004】 In recent years, plate-shaped vesicles such as Bycell have attracted particular attention (Non-Patent Literature 1). While typical vesicles are spherical, plate-shaped vesicles are expected to offer further improvements in stability and skin penetration. 【0005】 Prior art for plate-like vesicle dispersions containing ceramides includes stable plate-like vesicle dispersions containing phospholipids, cholesterol and phytosterols, surfactants such as certain PEG cholesteryl ethers and PEG phytosteryl ethers, dihydric alcohols and water (Patent Document 1, Patent Document 2). 【0006】 However, in recent years, with consumers increasingly favoring natural products, ingredients derived from petroleum or those that have undergone complex chemical synthesis, particularly PEG-based surfactants, tend to be avoided. 【0007】 While the compositions of the prior art described above exhibit excellent long-term stability and pose no industrial problems, they contain PEG-based surfactants. Therefore, a technology for producing plate-like vesicle dispersions containing ceramide without PEG-based surfactants is likely to be well-received by natural-minded consumers and is considered to be an extremely valuable technology from an industrial perspective. 【0008】 Furthermore, when topical skin preparations such as cosmetics are applied to the skin, volatile components such as water evaporate, ultimately leaving a film on the skin that contains almost no water. Ceramide-containing compositions also form a film in the same way, but at this time, crystals often precipitate as the ceramide concentration increases. In recent years, it has been reported that formulations in which crystals do not precipitate even in the state of the film after application further enhance the absorption of ceramide into the skin, and it has become clear that controlling the structure of the film greatly affects the value of the formulation (Non-Patent Literature 2). 【0009】 Therefore, plate-like vesicle dispersions that do not contain PEG-based surfactants and do not cause ceramide crystal precipitation even in the form of a coating are considered to be technologies of even greater industrial value. [Prior art documents] [Patent Documents] 【0010】 [Patent Document 1] Patent Application No. 2017-552736 [Patent Document 2] Patent Application No. 2019-128893 [Non-patent literature] 【0011】 [Non-Patent Document 1] "Journal of the Japan Society of Cosmetic Scientists," Vol. 55, No. 3, p. 250, 2021, published by the Japan Society of Cosmetic Scientists. [Non-Patent Document 2] "Journal of the Japan Society of Cosmetic Scientists," Vol. 53, No. 4, p. 271, 2019, published by the Japan Society of Cosmetic Scientists. [Overview of the Initiative] [Problems that the invention aims to solve] 【0012】 The object of the present invention is to provide a ceramide-containing plate-shaped vesicle dispersion that does not precipitate ceramide crystals and has excellent temporal stability, and further to provide a ceramide-containing plate-shaped vesicle dispersion that does not precipitate ceramide crystals and has excellent temporal stability, and also does not precipitate ceramide crystals even in the state of a coating film. Another object is to provide a cosmetic composition containing the ceramide-containing plate-shaped vesicle dispersion. [Means for solving the problem] 【0013】 In view of these circumstances, the inventors have conducted diligent studies and have found that a ceramide-containing plate-shaped vesicle dispersion, characterized by containing component (A) ceramide, component (B) one or more selected from sucrose palmitate and sucrose stearate having an HLB value of 11 or higher, component (C) polyhydric alcohol and component (D) water, wherein the content of component (B) is 8% by weight or less, the weight ratio (B) / (A) is 2 or more, the weight ratio (C) / (B) is 0.5 or more, and if component (E) contains an oil that is liquid at 25°C, the weight ratio (E) / (B) is 0.25 or less, and the average particle diameter is 200 nm or less, does not cause ceramide crystals to precipitate and exhibits excellent stability over time. Furthermore, cosmetics containing this ceramide-containing plate-shaped vesicle dispersion also exhibit excellent stability over time and do not cause crystals to precipitate. Furthermore, it was found that by making 50% or more of component (C) polyhydric alcohol of the above-mentioned ceramide-containing plate-shaped vesicle dispersion a trihydric or higher polyhydric alcohol, ceramide crystals do not precipitate, resulting in excellent stability over time, and ceramide crystals do not precipitate even in the state of a coating film. It was also found that in cosmetics containing this ceramide-containing plate-shaped vesicle dispersion, ceramide crystals do not precipitate, resulting in excellent stability over time, and ceramide crystals do not precipitate even in the state of a coating film. 【0014】 That is, the present invention provides a ceramide-containing lamellar vesicle dispersion characterized by containing component (A) ceramide, component (B) one or more selected from sucrose palmitate and sucrose stearate having an HLB value of 11 or more, component (C) polyhydric alcohol, and component (D) water, wherein the content of component (B) is 8% by weight or less, the weight ratio (B) / (A) is 2 or more, the weight ratio (C) / (B) is 0.5 or more, and when containing component (E) an oil agent that is liquid at 25°C, the weight ratio (E) / (B) is 0.25 or less, and the average particle diameter is 200 nm or less. 【0015】 Further, the present invention provides a ceramide-containing lamellar vesicle dispersion in which 50% by weight or more of component (C) polyhydric alcohol is a polyhydric alcohol having 3 or more valences. 【0016】 Further, the present invention provides a cosmetic characterized by containing the above ceramide-containing lamellar vesicle dispersion. 【Effects of the Invention】 【0017】 According to the present invention, it is possible to provide a ceramide-containing lamellar vesicle dispersion in which ceramide crystals do not precipitate and which has excellent stability over time, and a cosmetic containing the ceramide-containing lamellar vesicle dispersion. Furthermore, it is possible to provide a ceramide-containing lamellar vesicle dispersion in which ceramide crystals do not precipitate, which has excellent stability over time, and in which ceramide crystals also do not precipitate in the state of the coating film, and a cosmetic containing the ceramide-containing lamellar vesicle dispersion. 【Brief Description of the Drawings】 【0018】 [Figure 1] Figure 1 is a transmission electron microscope image of the lamellar vesicle dispersion of Example 3. [Figure 2] Figure 2 is a scattering spectrum in the X-ray scattering measurement of the lamellar vesicle dispersion of Example 3. [Figure 3] Figure 3 is a polarized light microscope image of the coating film of Example 39. [Figure 4] Figure 4 is a polarized light microscope image of the coating film of Example 40. [Figure 5]Figure 5 shows the scattering spectrum of the coating film of Example 39 obtained from X-ray scattering measurement. [Figure 6] Figure 6 shows the scattering spectrum of the coating film of Example 40 obtained from X-ray scattering measurement. [Modes for carrying out the invention] 【0019】 The present invention will be described in detail below. The component (A) ceramide used in the present invention is a general term for compounds in which a long-chain fatty acid is amide-bonded to the amino group of sphingosine. There are several types of ceramides, which are classified according to differences in the structure of sphingosine and the long-chain fatty acid. For example, ceramide EOP, ceramide NG, ceramide NP, ceramide AG, and ceramide AP are known. Any of these ceramides can be used as component (A) ceramide in the present invention, but among them, ceramide NG, ceramide NP, ceramide AG, and ceramide AP are preferred. Furthermore, one or more of these can be used as needed. As ceramide NG, for example, ceramide TIC-001 manufactured by Takasago International Corporation can be used. As ceramide NP, for example, Ceramide III and Ceramide IIIB manufactured by Evonik can be used. As ceramide AG, for example, ceramide TIC-006 manufactured by Takasago International Corporation can be used. As ceramide AP, for example, Ceramide VI manufactured by Evonik can be used. 【0020】 Component (B) of the present invention is one or more selected from sucrose palmitate and sucrose stearate, having an HLB value of 11 or higher. Sucrose palmitate and sucrose stearate are those in which the hydroxyl group of sucrose is ester-bonded to palmitic acid or stearic acid. 【0021】 The HLB value of component (B) is 11 or higher. If the HLB value is less than 11, separation or crystal precipitation may occur. The HLB values ​​of sucrose palmitate and sucrose stearate used in this invention are based on the values ​​listed in the catalog (Surfhope SE COSME May 2001 (Mitsubishi Chemical)). If two or more types of sucrose palmitate and sucrose stearate are included, the HLB value can be calculated assuming additivity. 【0022】 Commercially available sucrose palmitate and sucrose stearate can be used. For example, commercially available products from Mitsubishi Chemical, such as Surfhope SE COSME C-1615, Surfhope SE COSME C-1616, Surfhope SE COSME C-1811, Surfhope SE COSME C-1815, and Surfhope SE COSME C-1816, can be used. 【0023】 The content of component (B) is 8% by weight or less. If it is greater than 8% by weight, the composition will become gel-like and will not become a dispersion in which vesicles are dispersed in a dispersion medium such as water, and the objective of the present invention may not be achieved. 【0024】 Component (C) of the present invention is a polyhydric alcohol. Component (C) can be either a dihydric polyhydric alcohol or a trihydric or higher polyhydric alcohol. However, by making 50% or more by weight of component (C) a trihydric or higher polyhydric alcohol, it is possible to prevent ceramide crystals from precipitation even in the coated film state. Examples of trihydric or higher polyhydric alcohols include glycerin derivatives such as glycerin, diglycerin, and polyglycerin, and sugar alcohols obtained by adding hydrogen to the carbonyl group of sugars (reduction reaction), such as sorbitol, mannitol, and xylitol. Examples of dihydric polyhydric alcohols include, but are not limited to, pentylene glycol, butylene glycol, propylene glycol, dipropylene glycol, hexylene glycol, and isoprene glycol. Any polyhydric alcohol commonly used as a cosmetic or pharmaceutical ingredient can be used. 【0025】 The content of components (A), (B), and (C) must satisfy the following weight ratios: (B) / (A) is 2 or greater, and (C) / (B) is 0.5 or greater. If the weight ratio (B) / (A) is less than 2 or the weight ratio (C) / (B) is less than 0.5, the average particle size will increase, and separation or crystal precipitation may occur. 【0026】 Furthermore, in the present invention, when component (E) contains an oil that is liquid at 25°C, the weight ratio (E) / (B) is 0.25 or less, and more preferably 0.05 or less. If the weight ratio (E) / (B) is greater than 0.25, the average particle size will increase, and separation or crystal precipitation may occur. 【0027】 Ingredients (E) include oils that are liquid at 25°C, such as isododecane, isohexadecane, liquid paraffin, α-olefin oligomer, squalane, hydrogenated polyisobutene, oleic acid, isostearic acid, linoleic acid, oleyl alcohol, isostearyl alcohol, avocado oil, olive oil, peach kernel oil, kukui nut oil, grape seed oil, safflower oil, almond oil, corn oil, pistachio seed oil, sunflower oil, hazelnut oil, macadamia nut oil, meadowfoam oil, rosehip oil, and diisononyl alcohol. Butyl ester, jojoba oil, butyl myristate, butyl stearate, cetyl ethylhexanoate, ethyl oleate, hexyldecyl isostearate, octyldodecyl myristate, isocetyl myristate, isocetyl stearate, ethylhexyl palmitate, isopropyl isostearate, isopropyl myristate, isopropyl palmitate, isostearyl palmitate, octyldodecyl myristate, ethylhexyl stearate, ethyl linoleate, isopropyl linoleate, octyl neopentanoate Decyl, Butyloctyl salicylate, Diglyceryl triisostearate, Propylene glycol dicaprate, Pentaerythrityl tetraethylhexanoate, Propylene glycol monocaprylate, Propylene glycol dicaprylate, Trimethylolpropane triethylhexanoate, Trimethylolpropane triisostearate, Glyceryl tri-2-ethylhexanoate, Caprylic / capric triglyceride, 2-butyl-2-ethyl-1,3-propanediol 2-ethylhexanoate, Diethyl sebacate, Examples include diisopropyl adipate, diisopropyl sebacate, di-2-ethylhexyl 2,6-naphthalenedicarboxylate, dibutyloctyl sebacate, diisostearyl malate, triethylhexyl citrate, diglyceryl triisostearate, decaglyceryl pentaoleate, decaglyceryl decaisostearate, decaglyceryl decaoleate, decaglyceryl decamacadamiate, dimethyl silicone, methylphenyl silicone, cyclic dimethyl silicone, alkyl-modified silicone, etc. 【0028】 The average particle size of the present invention was determined by dynamic light scattering measurement using nanoSAQLA (manufactured by Otsuka Electronics) and calculated by cumulant analysis. The average particle size of the ceramide-containing plate-shaped vesicle dispersion of the present invention is 200 nm or less. 【0029】 The ceramide-containing plate-shaped vesicle dispersion of the present invention may appropriately contain various components, such as surfactants, UV absorbers, preservatives, humectants, thickeners, colorants, metal ion chelating agents, antioxidants, cosmetic ingredients, fragrances, cooling agents, pH adjusters, etc., depending on its intended use. 【0030】 In this invention, by incorporating the above-mentioned ceramide-containing plate-shaped vesicle dispersion into a cosmetic composition, a ceramide-containing cosmetic composition can be provided that does not precipitate ceramide crystals and exhibits excellent long-term stability. Furthermore, by incorporating the above-mentioned ceramide-containing plate-shaped vesicle dispersion into a cosmetic composition in which 50% by weight or more of component (C) polyhydric alcohol is a trihydric or higher polyhydric alcohol, a ceramide-containing cosmetic composition can be provided that does not precipitate ceramide crystals, exhibits excellent long-term stability, and does not precipitate ceramide crystals even in the state of a coated film. In addition, the ceramide-containing vesicle dispersion itself can also be used as a cosmetic composition. 【0031】 The cosmetic composition containing the ceramide-containing plate-shaped vesicle dispersion of the present invention may appropriately contain various components, such as surfactants, UV absorbers, preservatives, humectants, thickeners, colorants, metal ion chelating agents, antioxidants, cosmetic ingredients, fragrances, cooling agents, pH adjusters, etc., depending on the intended use, as long as the effects of the invention are not impaired. 【0032】 Cosmetics containing the ceramide-containing plate-shaped vesicle dispersion of the present invention can be exemplified by, but are not limited to, basic cosmetic products such as lotions, serums, and face masks. [Examples] 【0033】 The present invention will be described in more detail below with reference to examples, but the present invention is not limited in any way by these examples. All content in the examples is in weight percent. 【0034】 Examples 1 to 41, Comparative Examples 1 to 12: Ceramide-containing plate-shaped vesicle dispersions The preparation method and evaluation method for the ceramide-containing plate-shaped vesicle dispersion of the present invention will be described in detail. In the formulations shown in Examples 1 to 41 and Comparative Examples 1 to 12 below, part A was heated to 80°C, mixed and uniformly dissolved, then part B, which had also been heated to 80°C, was added to part A, and then cooled to 30°C to obtain a ceramide-containing plate-shaped vesicle dispersion. The appearance of the obtained ceramide-containing plate-shaped vesicle dispersion was observed and the average particle size was measured. The appearance was also observed and the average particle size was measured again after standing at 40°C for one month to confirm its stability over time. Only if these results were satisfactory, the presence or absence of ceramide crystals in the coating film was confirmed by polarized light microscopy. 【0035】 The external observation evaluation was conducted as follows. The obtained ceramide-containing plate-like vesicle dispersions were visually observed and classified as follows. <External observation> ○: Uniform, with no separation or crystal precipitation observed. ×: Separation or crystal precipitation is observed. 【0036】 The average particle size was determined by dynamic light scattering measurements using nanoSAQLA (manufactured by Otsuka Electronics) and calculated using cumulant analysis. 【0037】 After standing at 40°C for one month, the appearance was observed, and the condition of the coating film was also observed only in the examples that showed good results. Polarized light microscopy observation to confirm the presence or absence of ceramide crystals in the coating film was performed as follows. 1. Spread 3g of ceramide-containing plate-shaped vesicle dispersion uniformly in a glass petri dish with a diameter of 5cm and a height of 1.5cm, and leave it standing for 24 hours at 32°C and 40% Rh. (Since the weight of the coating film prepared under these conditions was almost the same as the weight excluding the volatile component (water), it can be considered that almost all of the volatile components have evaporated from the coating film.) 2. Observe the coating remaining in the petri dish using a polarizing microscope. <Polarized light microscopy observation of coating films> ○: No crystal precipitation is observed. ×: Crystal precipitation is observed. 【0038】 [Table 1] *1: Ceramide TIC-001 (manufactured by Takasago International Corporation) *2: Ceramide III (manufactured by Evonik) *3: Ceramide TIC-006 (manufactured by Takasago International Corporation) *4: Ceramide VI (manufactured by Evonik) *5: Surfhope SE COSME C-1816 (manufactured by Mitsubishi Chemical) *6: RG Co. P (manufactured by NOF Corporation) 【0039】 Table 1 shows the results when the weight ratio (B) / (A) and the type of component (A) ceramide were changed. In Examples 1 to 7, where the weight ratio (B) / (A) was 2 or greater, the appearance was good and the average particle size was 200 nm or less, and this remained the same even after standing at 40°C for one month. Furthermore, good results were obtained for all ceramides, including NG, NP, AG, and AP. On the other hand, in Comparative Example 1, where the weight ratio (B) / (A) was less than 2, the average particle size was larger than 200 nm, and after standing at 40°C for one month, the average particle size increased, and separation and crystal precipitation were observed. 【0040】 [Table 2] 【0041】 Table 2 shows the results when the content of component (B) sucrose stearate was varied. In Examples 8 to 12, where the content of component (B) sucrose stearate was 8% by weight or less and the weight ratio (B) / (A) was 2 or more, the appearance was good and the average particle size was 200 nm or less, and this remained the same even after standing at 40°C for one month. On the other hand, in Comparative Example 2, where the content of component (B) sucrose stearate was 8% by weight or less but the weight ratio (B) / (A) was less than 2, the average particle size was larger than 200 nm, and after standing at 40°C for one month, the average particle size increased, and separation and crystal precipitation were observed. Furthermore, in Comparative Example 3, where the content of component (B) sucrose stearate was greater than 8% by weight, it became gel-like and did not become a vesicle dispersion, and the average particle size could not be measured. 【0042】 [Table 3] *7: Surfhope SE COSME C-1616 (manufactured by Mitsubishi Chemical) *8: Surf Hope SE COSME C-1815 (manufactured by Mitsubishi Chemical) *9: Surfhope SE COSME C-1811 (manufactured by Mitsubishi Chemical) *10: Surfhope SE COSME C-1809 (manufactured by Mitsubishi Chemical) *11: Surfhope SE COSME C-1216 (manufactured by Mitsubishi Chemical) *12: NIKKOL Decaglyn 1-SV (manufactured by Nikko Chemicals) *13: NIKKOL BPS-30 (manufactured by Nikko Chemicals) *14: EMALEX 830 (manufactured by Nippon Emulsion Co., Ltd.) 【0043】 Table 3 shows the results when the HLB values ​​of component (B) sucrose stearate and sucrose palmitate were changed, and when sucrose laurate, polyglyceryl-10 stearate, POE-30 phytosterol, and PEG-30 stearate were included instead of component (B). In Examples 13-16, where the HLB values ​​of component (B) sucrose stearate and sucrose palmitate were 11 or higher, the appearance was good and the average particle size was 200 nm or less, and this remained the same even after standing at 40°C for one month. On the other hand, in Comparative Example 4, where the HLB value of sucrose stearate was less than 11, the appearance was good and the average particle size was 200 nm or less immediately after preparation, but separation and crystal precipitation were observed after standing at 40°C for one month. Furthermore, in Comparative Examples 5-8, which contained sucrose laurate, polyglyceryl-10 stearate, POE-30 phytosterol, and PEG-30 stearate instead of component (B), separation and crystal precipitation were observed immediately after preparation, and the average particle size became larger than 200 nm. 【0044】 [Table 4] *15: Diglycerin S (manufactured by Sakamoto Pharmaceutical Co., Ltd.) *16: Sorbitol D-70 (manufactured by Mitsubishi Corporation Life Sciences) *17: Xylitol (manufactured by Mitsubishi Corporation Life Sciences) 【0045】 Table 4 shows the results when the content of component (C) polyhydric alcohol was varied, and when component (C) contained diglycerin, sorbitol, and xylitol. In Examples 17-22, where the weight ratio (C) / (B) was 0.5 or higher, the appearance was good and the average particle size was 200 nm or less, and this remained the case even after standing at 40°C for one month. In Examples 23-25, where component (C) contained diglycerin, sorbitol, and xylitol, the appearance was also good and the average particle size was 200 nm or less, and this remained the case even after standing at 40°C for one month. On the other hand, in Comparative Example 9, where the weight ratio (C) / (B) was less than 0.5, separation and crystal precipitation were observed, and the average particle size became larger than 200 nm. 【0046】 [Table 5] *18: CARNATION (Made by SONNEBORN) *19: Isostearic acid (manufactured by Nissan Chemical Industries) *20: ODM (Manufactured by Kogyo Kogyo) 【0047】 Table 5 shows the results when the content of component (E), an oil that is liquid at 25°C, was varied. In Examples 26-34, where the weight ratio (E) / (B) was 0.25 or less, the appearance was good and the average particle size was 200 nm or less, and this remained the case even after standing at 40°C for one month. In particular, Examples 26, 27, 29, 30, 32, and 33, where the weight ratio (E) / (B) was 0.05 or less, showed less change in average particle size before and after standing at 40°C for one month compared to Examples 28, 31, and 34, where the weight ratio (E) / (B) was 0.25, and exhibited superior long-term stability. On the other hand, in Comparative Examples 10-12, where the weight ratio (E) / (B) was greater than 0.25, the appearance was good and the average particle size was 200 nm or less immediately after preparation, but after standing at 40°C for one month, the average particle size increased, and separation and crystal precipitation were observed. 【0048】 [Table 6] *21:1,3-Butylene glycol (manufactured by Daicel) *22: Hydrolite 5 Green (manufactured by Simrise) *23: DPG-FC (manufactured by AGC) 【0049】 Table 6 shows the results when the proportion of trivalent or higher polyhydric alcohols in component (C) is varied, and when various types of divalent polyhydric alcohols are included as component (C). In Examples 37-39, where 50% by weight or more of component (C) polyhydric alcohols were trivalent or higher polyhydric alcohols, the appearance was good and the average particle size was 200 nm or less, and this remained the same even after standing at 40°C for one month. In addition, no crystals were observed in polarized light microscopy of the coating film. Furthermore, in Examples 40 and 41, which contained various types of divalent polyhydric alcohols, the appearance was also good and the average particle size was 200 nm or less, and this remained the same even after standing at 40°C for one month. 【0050】 Examples of cosmetic compositions containing ceramide-containing plate-shaped vesicle dispersions are given below. In these examples, no separation or crystal precipitation was observed, and no changes were seen even after standing at 40°C for one month. Furthermore, the state of the coating film was checked under the same conditions as for the ceramide-containing plate-shaped vesicle dispersion, but no ceramide crystals were observed. 【0051】 (Example 42: Lotion) (Ingredient name) Weight (%) (1) Water remainder (2) Glycerin (*6) 12.0 (3) Dipropylene glycol (*23) 5.0 (4) Citric acid 0.1 (5) Sodium citrate 0.3 (6) Sodium metaphosphate 0.1 (7) Sodium hyaluronate 0.01 (8) Magnesium ascorbate phosphate 0.01 (9) Dipotassium glycyrrhizinate 0.05 (10) Ethanol 12.0 (11) Methylparaben 0.1 (12) Phenoxyethanol 0.1 (13) Ceramide-containing plate-shaped vesicle dispersion of Example 4 10.0 (Manufacturing method) 1. Mix ingredients (1) to (12) and dissolve them uniformly. 2. Add ingredient (13) to ingredients (1) to (12). 【0052】 (Example 43: Beauty serum) (Ingredient name) Weight (%) (1) Water remainder (2) Glycerin (*6) 10.0 (3) Sorbitol (70% aqueous solution) (*16) 10.0 (4) Diglycerin (*15) 3.0 (5) EDTA-2Na 0.05 (6) Xanthan gum 0.4 (7) Sodium hyaluronate 0.1 (8) Water-soluble collagen 0.1 (9) 1,3-Butylene glycol (*21) 4.0 (10) Methylparaben 0.2 (11) Polyglyceryl-10 isostearate 0.5 (12) Polyglyceryl-10 Laurate 0.2 (13) Flavoring (appropriate amount) (14) Ceramide-containing plate-shaped vesicle dispersion of Example 27 10.0 (Manufacturing method) 1. Mix ingredients (1) to (10) and dissolve them uniformly. 2. Mix ingredients (11) to (13) and dissolve them uniformly. 3. Add ingredients (11) to (13) and ingredient (14) to ingredients (1) to (10). 【0053】 Transmission electron microscopy was performed to confirm the structure of the ceramide-containing plate-like vesicle dispersion of the present invention. 【0054】 Figure 1 shows a transmission electron microscope image of the dispersion from Example 3. The presence of plate-like dispersions was confirmed. 【0055】 X-ray scattering measurements were performed to confirm the structure of the ceramide-containing plate-like vesicle dispersion of the present invention. Measurements were performed with an X-ray energy of 13.9 keV, an X-ray wavelength of 0.09 nm, and an irradiation time of 100 seconds. The obtained scattering images were converted to one dimension to obtain a scattering spectrum. 【0056】 Figure 2 shows the scattering spectrum of the dispersion from Example 3. The scattering intensity on the vertical axis and the scattering vector Q on the horizontal axis are plotted logarithmically, and from Figure 2 it can be seen that the region around Q 0.1 has a slope of -2. This indicates that the vesicles are plate-shaped. From the results in Figures 1 and 2 it can be seen that the scattering material of the present invention consists of plate-shaped vesicles. 【0057】 Figure 3 shows a polarized light microscope image of the coating film of Example 39, and Figure 4 shows a polarized light microscope image of the coating film of Example 40. In the coating films of Examples 37, 38, and 39, where 50% by weight or more of component (C) polyhydric alcohol is a trivalent or higher polyhydric alcohol, polarized light microscope images like those in Figure 3 were observed, and no crystals were observed. On the other hand, in the coating films of Examples 35, 36, 40, and 41, where the amount of trivalent or higher polyhydric alcohol in component (C) is less than 50% by weight, crystals were confirmed to appear as granular structures, as shown in Figure 4. 【0058】 To confirm the structure of the coating film of the ceramide-containing plate-shaped vesicle dispersion of the present invention, X-ray scattering measurements were performed using the same method as described above, and a one-dimensional scattering spectrum was obtained. 【0059】 Figure 5 shows the scattering spectrum of the coating film of Example 39. In the coating film of Example 39, the primary, secondary, tertiary, quaternary, and quintic peaks indicating the presence of a lamellar structure are each at 0.285 nm. -1 , 0.577nm -1 , 0.863nm -1 , 1.15nm -1 , 1.44nm -1 It appears there, and it can be seen that there is a lamellar structure with a period of approximately 20 nm. Also, when ceramide crystals precipitate, 1.5 nm -1Although sharp peaks derived from crystals are observed around it, since such peaks were not observed, it is confirmed that crystal precipitation does not occur even in the coating film. 【0060】 Figure 6 shows the scattering spectrum of the coating film of Example 40. In the coating film of Example 40, at 1.48 nm -1 , 2.95 nm -1 , 4.42 nm -1 sharp peaks appear, and these are considered to be peaks derived from the crystals of ceramide. 【Industrial Applicability】 【0061】 According to the present invention, it is possible to provide a ceramide-containing lamellar vesicle dispersion in which crystals of ceramide do not precipitate and which has excellent stability over time, and further a ceramide-containing lamellar vesicle dispersion in which crystals of ceramide do not precipitate, which has excellent stability over time and in which crystals of ceramide do not precipitate even in the state of a coating film. In addition, it is possible to provide a cosmetic containing the ceramide-containing lamellar vesicle dispersion.

Claims

[Claim 1] A ceramide-containing plate-shaped vesicle dispersion characterized by containing component (A) ceramide, component (B) one or more selected from sucrose palmitate and sucrose stearate having an HLB value of 11 or higher, component (C) polyhydric alcohol and component (D) water, wherein the content of component (B) is 8% by weight or less, the weight ratio (B) / (A) is 2 or more, the weight ratio (C) / (B) is 0.5 or more, and if component (E) contains an oil that is liquid at 25°C, the weight ratio (E) / (B) is 0.25 or less, and the average particle size is 200 nm or less. [Claim 2] The ceramide-containing plate-shaped vesicle dispersion according to claim 1, characterized in that 50% by weight or more of the aforementioned component (C) polyhydric alcohol is a trihydric or higher polyhydric alcohol. [Claim 3] A cosmetic composition characterized by containing the ceramide-containing plate-shaped vesicle dispersion described in claim 1 or 2.

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