Devices and methods for transarterial osmotic embolization of pathological tissue.

Abstract

This provides a novel device / system that promotes osmotic embolism formation. [Solution] An intravascular intervention method is provided, comprising the steps of: inserting a catheter into a target vessel, wherein the catheter is coupled to a system that provides continuous delivery of a contrast agent and a hyperosmolar fluid; injecting a contrast agent and determining a flow rate to achieve angiographic filling of the target vessel at a first time point; continuously injecting a hyperosmolar fluid at a flow rate to achieve angiographic filling over a first period at the first time point; injecting a contrast agent and determining a flow rate to achieve angiographic filling of the target vessel at a second time point following the first period; and continuously injecting a hyperosmolar fluid at a flow rate to achieve angiographic filling over a second period at the second time point.

Claims

1. The steps include inserting a catheter into a target vessel, wherein the catheter is coupled to a system that provides continuous delivery of contrast agent and hyperosmolar fluid, The steps include: injecting the contrast agent and determining the flow rate to achieve angiographic filling of the target vessel at a first time point; The steps include: continuously injecting the hyperosmolar fluid at the flow rate required to achieve filling by angiography over a first period of time at the first time point; A step of injecting the contrast agent and determining the flow rate to achieve angiographic filling of the target vessel at a second time point following the first period, The steps include: continuously injecting the hyperosmolar fluid at the flow rate required to achieve filling by angiography over a second period of time at the second time point; Intravascular intervention methods, including those mentioned above.

2. The method according to claim 1, wherein the aforementioned high-osmotic fluid includes an osmotic embolizer.

3. The method according to claim 1, wherein the first period is approximately 20 minutes to approximately 30 minutes.

4. The method according to claim 1, wherein the second period is approximately 20 minutes to approximately 30 minutes.

5. The method according to claim 1, comprising repeating the step of injecting the contrast agent and the hyperosmolar fluid until the flow rate at the second time point is reduced.

6. The method according to claim 1, further comprising repeating the step of injecting the contrast agent and the hyperosmolar fluid until the flow rate at the second time point is reduced to a negligible flow rate.

7. The method according to claim 1, further comprising repeating the step of injecting the contrast agent and the hyperosmolar fluid until the flow rate at the second time point indicates the completion of osmotic embolization in the target vessel.

8. The method according to claim 1, wherein when the flow of the high-osmotic fluid is turned on, the flow of the contrast agent is turned off.

9. The method according to claim 1, wherein when the flow of the contrast agent is turned on, the flow of the hyperosmolar fluid is turned off.

10. The method according to claim 1, wherein the system comprises at least one sensor for determining the flow rate, and the first and second flow rates are determined based on feedback from the at least one sensor.

11. The method according to claim 1, wherein the system comprises at least one sensor for determining the osmolality or molar osmotic pressure at a target site, and the system adjusts first and second flow rates based on feedback from the at least one sensor.

12. The method according to claim 11, wherein the system adjusts the flow rate to maintain a desired osmolality or molar osmotic concentration at the target site.

13. A system coupled to a catheter and operable to provide continuous delivery of contrast agent and hyperosmolar fluid, the system comprising a controller and a computer memory storing executable instructions that, when executed, cause the controller to perform a method, the method is The steps include: injecting the contrast agent and determining the flow rate to achieve angiographic filling of the target vessel at a first time point; The steps include: continuously injecting the hyperosmolar fluid at the flow rate required to achieve filling by angiography over a first period of time at the first time point; A step of injecting the contrast agent and determining the flow rate to achieve angiographic filling of the target vessel at a second time point following the first period, The steps include: continuously injecting the hyperosmolar fluid at the flow rate required to achieve filling by angiography over a second period of time at the second time point; A system that includes this.

14. The system according to claim 13, wherein the aforementioned high-osmotic fluid includes an osmotic embolizer.

15. The system according to claim 13, wherein the first and second periods are approximately 20 minutes to approximately 30 minutes.

16. The system according to claim 13, wherein the method comprises repeating the step of injecting the contrast agent and the hyperosmolar fluid until the flow rate at the second time point indicates the completion of osmotic embolization in the target vessel.

17. The system according to claim 16, comprising at least one sensor for determining flow rate, wherein first and second flow rates are determined based on feedback from the sensor.

18. The system according to claim 13, comprising at least one sensor for determining flow rate, wherein first and second flow rates are determined based on feedback from the at least one sensor.

19. The system according to claim 13, comprising at least one sensor for determining the osmolality or molar osmotic pressure at a target site, wherein the system adjusts first and second flow rates based on feedback from the at least one sensor.

20. The system according to claim 19, wherein the system adjusts the flow rate to maintain a desired osmolality or molar osmotic concentration at the target site.

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