Topical skin preparations

Abstract

This invention provides a topical skin preparation containing niacinamide that suppresses the feeling of tightness or irritation. [Solution] The topical skin preparation contains (A) 0.1 to 6% by mass of niacinamide, (B) 0.1 to 4% by mass of diglycerin, and (C) 0.0001 to 0.5% by mass of one or more selected amino acids and their salts. The topical skin preparation may also further contain (D) 0.0001 to 0.5% by mass of one or more selected extracts or fermented products from yuzu, soybean, lotus, royal jelly, and scutellaria baicalensis.

Description

【Technical Field】 【0001】 The present invention relates to an external preparation for skin. 【Background Art】 【0002】 Among various skin problems, "deep wrinkles" that occur on the skin with aging are one of the major concerns for women. Wrinkles include "shallow wrinkles" caused by dryness or mild external environmental changes, and "deep wrinkles" caused by factors such as photoaging or natural aging, which result in the alteration of dermal components. The former is relatively easy to improve by skin care such as moisturizing, while the latter is known to be difficult to improve without appropriate beauty ingredients or skin care. 【0003】 Regarding skin problems related to such deep wrinkles, in particular, niacinamide is known to be a vitamin with high safety and having an anti-skin aging effect (for example, Patent Document 1). However, when niacinamide is formulated at a high concentration, it is known to have an undesirable feeling of roughness, and improvements have been made in this regard. Examples include water-in-oil emulsified cosmetics using silicone oil and polyoxyalkylene-added glycerin derivatives (for example, Patent Document 2), gel-like external preparations for skin using silicone oil, polyether-modified silicone, and carboxymethyl cellulose (for example, Patent Document 3), leave-on skin care compositions using petrolatum (for example, Patent Document 4), etc. 【Prior Art Documents】 【Patent Documents】 【0004】 【Patent Document 1】 Japanese Patent No. 3922311 【Patent Document 2】 International Publication No. 2021 / 201136 【Patent Document 3】 Japanese Patent No. 7256624 【Patent Document 4】 Japanese Patent Application Publication No. 2003-502435 【Summary of the Invention】 [Problems that the invention aims to solve] 【0005】 The conventional topical skin preparations described above improve the squeaky feeling caused by niacinamide using oil-based methods, but methods to improve this squeaky feeling without relying on oil have not been sufficiently investigated. Given this background, there is a need for topical skin preparations containing niacinamide that suppress the squeaky feeling. 【0006】 This invention has been made in view of the above circumstances, and its purpose is to provide a topical skin preparation containing niacinamide that suppresses the feeling of tightness. [Means for solving the problem] 【0007】 As a result of diligent research to achieve the above objectives, the inventors of the present invention have discovered that by combining niacinamide, diglycerin, amino acids and their salts, it is possible to provide a topical skin preparation that does not feel sticky or greasy, has excellent moisturizing properties for the skin, and provides firmness and elasticity, thus completing the present invention. 【0008】 The topical skin preparation according to the present invention is a topical skin preparation containing the following (A) to (C). (A) Niacinamide 0.1-6% by mass (B) Diglycerin 0.1-4% by mass (C) One or more amino acids and their salts selected from 0.0001 to 0.5% by mass 【0009】 The topical skin preparation according to the present invention may contain the following (D). (D) One or more extracts or fermented products selected from yuzu, soybeans, lotus, royal jelly, and scutellaria baicalensis, in a quantity of 0.0001-0.5% by mass. [Effects of the Invention] 【0010】 This invention makes it possible to suppress the squeaky feeling caused by niacinamide. [Modes for carrying out the invention] 【0011】 The following describes in detail the topical skin preparation according to this embodiment, but the present invention is not limited to the following embodiments. The present invention is not limited to the configurations described below, and various modifications are possible within the scope of the claims, and embodiments and examples obtained by appropriately combining the technical means disclosed in different embodiments and examples are also included in the technical scope of the present invention. Furthermore, unless otherwise specified in this specification, "A~B" representing a numerical range means "A or more, B or less". 【0012】 The topical skin preparation according to this embodiment contains (A) niacinamide, (B) diglycerin, and (C) one or more selected from amino acids and their salts. 【0013】 <(A) Niacinamide> Component (A) used in the topical skin preparation according to this embodiment is niacinamide. Niacinamide is one of the B vitamins, which are water-soluble vitamins, and is also called nicotinamide. Niacinamide can be used without particular restrictions as long as it is commonly used in pharmaceuticals, quasi-drugs, and cosmetics, and these may be natural or synthetic. Niacinamide is known to have effects such as wrinkle improvement, blood circulation promotion, rough skin improvement, melanin production inhibition, and skin whitening. 【0014】 Niacinamide is available as a commercially available cosmetic ingredient. Examples of commercially available products include "Niacinamide USP PC (manufactured by Arcsada Japan)" and "Nicotinamide (manufactured by DSM)." 【0015】 The topical skin preparation according to this embodiment can suppress a prickling sensation by containing niacinamide as component (A) and one or more selected from (C) amino acids and their salts described below. 【0016】 The blending amount of component (A) is 0.1 to 6% by mass in the total mass of the topical skin preparation, preferably 0.5 to 5% by mass. If the blending amount of component (A) is 0.1% by mass or more, a sufficient moisturizing effect and an effect of improving the firmness of the skin can be obtained. On the other hand, if the blending amount of component (A) is 6% by mass or less, prickling can be suppressed by combining with component (C) described below. 【0017】 <(B) Diglycerin> Component (B) used in the topical skin preparation according to this embodiment is diglycerin. Diglycerin is a kind of polyhydric alcohol having four hydroxyl groups, which is a dimer in which two glycerins are bonded. 【0018】 Component (B) in the topical skin preparation according to this embodiment gives moisture (moisturizing effect) to the skin. 【0019】 The blending amount of component (B) is 0.1 to 4% by mass in the total mass of the topical skin preparation, preferably 0.3 to 3% by mass. If the blending amount of component (B) is 0.1% by mass or more, a sufficient moisturizing effect can be obtained. On the other hand, if the blending amount of component (B) is 4% by mass or less, stickiness resulting from an increase in the blending amount of component (B) can be sufficiently suppressed. 【0020】 <One or more selected from (C) amino acids and their salts> Component (C) used in the topical skin preparation according to this embodiment is one or more selected from amino acids and their salts. Amino acids are a general term for organic compounds having carboxyl and amino functional groups, and are classified into α-amino acids, β-amino acids, γ-amino acids, δ-amino acids, etc., depending on the position of the functional groups, but are not particularly limited as long as they are used as components of topical skin preparations in the fields of pharmaceuticals, quasi-drugs, or cosmetics. These components are available as commercially available cosmetic raw materials. The amino acids used in the topical skin preparation of the present invention are not particularly limited, but include glycine, serine, threonine, alanine, valine, leucine, isoleucine, asparagine, glutamine, cysteine, methionine, phenylalanine, tyrosine, tryptophan, citrulline, azaserine, cystathionine, homocysteine, S-adenosylhomocysteine, S-adenosylmethionine, ε-N-acetyllysine, proline, 4-hydroxyproline, N-methylglycine, N-acetylserine, N-acetylcysteine, arginine, lysine, histidine, ornithine, ω-N-methylarginine, ε-N,N,N-trimethyllysine, 5-hydroxylysine, 3-methylhistidine, aspartic acid, glutamic acid, γ-carboxyglutamic acid, O-phosphoserine, aminobutyric acid, etc. In addition, salts of the above-mentioned amino acids may be used as component (C) of the topical skin preparation according to this embodiment. Examples of amino acid salts include sodium salts, potassium salts, magnesium salts, and calcium salts. 【0021】 In the topical skin preparation according to this embodiment, component (C), when included together with component (A), suppresses tightness and further synergistically improves firmness and elasticity. 【0022】 The amount of component (C) is 0.0001 to 0.5% by mass of the total mass of the topical skin preparation, preferably 0.001 to 0.1% by mass. If the amount of component (C) is 0.0001% by mass or more, it can suppress the squeaking caused by component (A) and the stickiness caused by component (B). On the other hand, if the amount of component (C) is 0.5% by mass or less, it can suppress the unpleasant odor caused by component (C). If the topical skin preparation contains multiple types of amino acids and their salts, which are component (C), the amount of component (C) is the total amount of the amino acids and their salts. 【0023】 The topical skin preparation according to this embodiment contains (A) 0.1 to 6% by mass of niacinamide, (B) 0.1 to 4% by mass of diglycerin, and (C) 0.0001 to 0.5% by mass of one or more amino acids and their salts, thereby suppressing the squeaky feeling caused by niacinamide, further suppressing skin stickiness, and providing moisture and firmness to the skin. 【0024】 <(D) Extracts and fermented products of yuzu, soybeans, lotus, royal jelly, and scutellaria baicalensis> The topical skin preparation according to this embodiment may optionally contain, as an additional (D) component, an extract or fermented product of yuzu, soybean, lotus, royal jelly, or scutellaria baicalensis. The topical skin preparation may contain only one of the extracts and fermented products of yuzu, soybean, lotus, royal jelly, or scutellaria baicalensis as component (D), or two or more. 【0025】 The topical skin preparation according to this embodiment synergistically improves firmness and elasticity by containing component (D). 【0026】 If the topical skin preparation according to this embodiment contains component (D), the amount of component (D) is preferably 0.0001 to 0.5% by mass of the total mass of the topical skin preparation, and more preferably 0% by mass. The amount is 0.001 to 0.1% by mass. If the amount of component (D) is 0.0001% by mass or more, firmness and elasticity can be further improved. On the other hand, if the amount of component (D) is 0.5% by mass or less, unpleasant odors derived from component (D) can be suppressed. In addition, if the topical skin preparation contains multiple types of extracts and fermented products of component (D), such as yuzu, soybean, lotus, royal jelly, and scutellaria baicalensis, the amount of these components is the total amount of amino acids and their salts. 【0027】 <Other ingredients> In addition to the components described above, the topical skin preparation according to this embodiment may appropriately contain other components, such as anionic surfactants, cationic surfactants, amphoteric surfactants, nonionic surfactants, oils, polymer compounds, thickeners, powders (dyes, resins, pigments), preservatives, fragrances, moisturizers, physiologically active ingredients, mineral salts, solvents, antioxidants, chelating agents, pearlescent agents, neutralizing agents, pH adjusters, and other components such as plant extracts and enzymes not listed in component (D) used in the topical skin preparation of the present invention, as long as the objective of the present invention is not impaired. 【0028】 Furthermore, the topical skin preparation according to this embodiment may contain physiologically active ingredients as appropriate, as long as it does not impair the objectives of the present invention. Physiologically active substances are substances that, when applied to the skin, provide some kind of physiological activity to the skin. Examples include anti-inflammatory agents, anti-aging agents, UV protection agents, astringents, antioxidants, blood circulation promoters, antibacterial agents, disinfectants, drying agents, cooling agents, warming agents, vitamins, amino acids, wound healing promoters, irritation relievers, analgesics, and cell activators. 【0029】 The topical skin preparation according to this embodiment can be manufactured according to conventional methods. Examples of topical skin preparations according to this embodiment include lotions, emulsions, creams, gels, serums, sheet masks, makeup, body lotions, body gels, body creams, and makeup bases. The dosage form can also be arbitrarily selected according to the purpose. Examples include liquids, creams, gels, emulsions, sheets, sticks, and aerosols. The topical skin preparation according to this embodiment is not limited to general cosmetics, but includes quasi-drugs, designated quasi-drugs, topical pharmaceuticals, etc. [Examples] 【0030】 Next, the topical skin preparation according to this embodiment will be described in detail based on examples, but is not limited thereto. Prior to the examples, the test methods and evaluation methods used in each example will be described. 【0031】 1. Evaluation test for the absence of skin tightness. Ten expert panelists washed their forearms with lukewarm water, then allowed them to acclimate for 20 minutes in an environment of 25°C and 50% relative humidity. Afterward, appropriate amounts of the topical skin preparations of the examples and comparative examples of the present invention were applied, and sensory evaluations were conducted on the feeling of tightness in the skin during and after use, using the following scoring method. The evaluation criteria were based on the average value of the sum of the scores given by five participants regarding the lack of tightness, and were classified as follows. 【0032】 <Rating and content regarding the lack of creaking> 5 points... I don't feel any tightness or dryness on my skin during or after use. 4 points... I felt a slight tightness in my skin during and after use. 3 points... I felt a slight tightness in my skin during and after use. Two points... I feel a tightness in my skin during and after use. 1. I felt a strong, unpleasant tightness on my skin during and after use. 【0033】 (Evaluation criteria for lack of creaking) ◎: Excellent (Average score of 5 people is 4 points or higher) ○: Good (Average score of 5 people is 3 or higher, but less than 4) △: Slightly poor (Average score of 5 people is 2 or higher, but less than 3 points) ×: Poor (Average score of 5 people is less than 2 points) 【0034】 2. Non-stickiness evaluation test Ten expert panelists washed their forearms with lukewarm water, then allowed them to acclimate for 20 minutes in an environment of 25°C and 50% relative humidity. Afterward, appropriate amounts of the topical skin preparations of the examples and comparative examples of the present invention were applied, and sensory evaluations were conducted on the stickiness of the skin during and after use, using the following scoring method. The evaluation criteria were based on the average value of the sum of the scores given by five participants regarding the lack of stickiness, and were classified as follows. 【0035】 <Rating and content regarding non-stickiness> 5 points... I don't feel any stickiness on my skin during or after use. 4 points... I felt a slight stickiness on my skin during and after use. 3 points... I felt a slight stickiness on my skin during and after use. Two points... I felt stickiness on my skin during and after use. One point: I felt a strong stickiness on my skin during and after use, which was unpleasant. 【0036】 (Evaluation criteria for non-stickiness) ◎: Excellent (Average score of 5 people is 4 points or higher) ○: Good (Average score of 5 people is 3 or higher, but less than 4) △: Slightly poor (Average score of 5 people is 2 or higher, but less than 3 points) ×: Poor (Average score of 5 people is less than 2 points) 【0037】 3. Skin moisture evaluation test For the evaluation panel of 10 participants, the forearms were washed with lukewarm water and then acclimatized for 20 minutes at a temperature of 25°C and a relative humidity of 50%. Afterward, appropriate amounts of the topical skin preparations of the examples and comparative examples of the present invention were applied, and the areas were again acclimatized for 20 minutes at a temperature of 25°C and a relative humidity of 50%. The stratum corneum moisture content (conductance value) was then measured using a Corneometer (MPA580, Courage+Khazaka). The moisturizing effect was evaluated by calculating the moisturizing effect (%) using the following formula, determining the average value for 5 participants, and then judging based on the following criteria. 【0038】 <Rating regarding skin moisturizing effect> Moisturizing effect (%) = (Skin stratum corneum moisture content after application / Stratum corneum moisture content before application) × 100 【0039】 (Evaluation criteria for skin moisturizing effect) ◎: Moisturizing effect (%) was 150% or higher. ○: The moisturizing effect (%) was between 120% and 150%. △: Moisturizing effect (%) was between 100% and 120%. ×: The moisturizing effect (%) was less than 100%. 【0040】 4. Skin firmness evaluation test Ten expert panel members had their cheeks washed with soap, then acclimatized for 20 minutes in an environment of 25°C and 50% relative humidity, after which 0.1 mL / cm³ of the aftershave agent according to the examples and comparative examples of the present invention was applied to their cheeks. 2 The product was applied. After application, the skin was allowed to acclimate for 60 minutes at a temperature of 25°C and a relative humidity of 50%, and the viscoelasticity of the skin was measured using a cutometer (MPA580, Courage+Khazaka). The effect of improving skin firmness and elasticity was evaluated by calculating the percentage of improvement in firmness and elasticity using the following formula, determining the average value for 10 subjects, and judging based on the following criteria. The results are shown in the table. 【0041】 <Calculation formula> Firmness and elasticity improvement effect (%) = (Skin elasticity 60 minutes after application / Skin elasticity before application) × 100 【0042】 <Judgment criteria> ◎: The firmness and elasticity improvement effect (%) was 150% or more. ○: The firmness and elasticity improvement effect (%) was between 150% and 120%. △: The firmness and elasticity improvement effect (%) was between 120% and 100%. ×: The firmness and elasticity improvement effect (%) was less than 100%. 【0043】 <Examples 1-4 and Comparative Examples 1-5> The topical skin preparations for each formulation in Examples 1-4 and Comparative Examples 1-5 shown in Table 1 were prepared by conventional methods and evaluated using the respective test methods. The results are also shown in Table 1. 【0044】 [Table 1] 【0045】 As is clear from Table 1, all of the topical skin preparations in the examples exhibited excellent performance. On the other hand, the comparative examples lacking any of the essential components were inferior in terms of lack of skin tightness, lack of skin stickiness, skin moisture, or skin firmness. 【0046】 The following are other examples of the topical skin preparation according to this embodiment. These topical skin preparations were also examined for the absence of skin tightness, non-stickiness, skin moisture, and skin firmness, and all exhibited excellent properties. 【0047】 Formula Example 1 (Beauty Serum) (by mass) 1. Niacinamide 4.0% 2. Yuzu fruit extract 0.02% 3. Peppermint leaf extract 0.01% 4. Retinyl palmitate 0.1% 5. Ascorbic acid 2-glucoside 3.0% 6. L-Ascorbic Acid Sulfate Disodium 0.7% 7. Loquat fruit extract 0.4% 8. Aminobutyric acid 0.3% 9. Job's Tears Seed Extract 0.01% 10. Lemon fruit extract 0.2% 11. Diphenylsiloxy Phenylen Trimethicone 0.8% 12. Trimethylsiloxyphenyl dimethicone 0.5% 13. Phenylentrimethicone 0.1% 14. Cyclohexane-1,4-dicarboxylic acid Bisethoxydiglycol 1.0% 15. Polyethylene glycol (average molecular weight 4000) 1.5% 16. Polyglycerin-6 3.0% 17. Methyl Gluceth-20 2.0% 18. Glycerin 10.0% 19. Dipropylene glycol 1.0% 20. Diglycerin 3.0% 21,1,3-Butylene glycol 0.5% 22. EDTA-2Na 0.01% 23. Xanthan gum 0.25% 24. Carboxyvinyl polymer 0.1% 25. Alkyl-modified carboxyvinyl polymer 0.01% 26. Hydroxyethylethylenediaminetriacetate trisodium 0.001% 27. PEG-60 Hydrogenated Castor Oil 0.5% 28. Polysorbate 20 0.2% 29. Citric acid 0.03% 30. Sodium citrate 0.03% 31.Fragrance 0.001% 32. Phenoxyethanol 0.3% 33. Hydroxyacetophenone 0.2% 34. Methylparaben 0.5% 35.Purified water remainder 【0048】 (Manufacturing method) (11) to (35) were heated to 80°C and dissolved uniformly. Then, they were cooled to 35°C, (1) to (10) were added and dissolved uniformly, and then filled into containers to prepare the beauty serum. 【0049】 Formula Example 2 (Serum) (by mass) 1. Gardenia blue extract 0.001% 2. Niacinamide 5.0% 3. Glucosyltrehalose 1.0% 4. Glycine 0.5% 5. Alaria esculenta extract 0.1% 6. Lactobacillus / Lotus Seed Ferment Filtrate 0.4% 7. Sodium glutamate 0.01% 8. Sage leaf extract 0.006% 9. Polyethylene glycol (average molecular weight 1000) 0.1% 10. Sodium polyacrylate 0.2% 11. Dipropylene glycol 10.0% 12. Diglycerin 2.0% 13. Polyoxyethylene glycerin (26 E.O.) 1.0% 14. Alkyl-modified carboxyvinyl polymer 0.15% 15. PEG-10 Glyceryl Triisostearate 0.1% 16. (PCA / Isostearate) PEG-40 Hydrogenated Castor Oil 0.1% 17. PEG-60 Hydrogenated Castor Oil 0.1% 18. Monopotassium phosphate 0.09% 19. Disodium phosphate 0.01% 20. Methylparaben 0.005% 21. Cyclohexylglycerin 0.5% 22. Squalane 0.1% 23. PEG-11 Methyl Ether Dimethicone 0.05% 24. Ethylhexyl palmitate 0.1% 25. Purified water remainder 【0050】 (Manufacturing method) Heat (1) to (21) and (25) to 80°C and stir to dissolve uniformly (Solution A). Heat (22) to (24) to 80°C and stir to disperse uniformly (Solution B). Add Solution B to Solution A, disperse in a homomixer until uniform, then cool to 30°C to create the beauty serum. 【0051】 Formula Example 3 (Whitening Makeup Base Cream) (by mass) 1. Arginine 0.05% 2. Yuzu Ceramide 0.01% 3. Glycosyltrehalose / hydrogenated starch hydrolysate mixed solution 0.1% 4. Niacinamide 4.5% 5. Scutellaria Baicalensis Root Extract 0.05% 6. Rosemary leaf extract 0.005% 7. Chamomile flower extract 0.0003% 8. Japanese knotweed root extract 2.5% 9. Kiwi extract 5.0% 10. Althaea root extract 0.0007% 11. Aloe vera juice 0.85% 12. Heparin-like substance 1.0% 13. Fennel fruit extract 1.0% 14. Brown algae extract 0.1% 15. Cyclohexane-1,4-dicarboxylic acid Bisethoxydiglycol 0.1% 16. Dipotassium glycyrrhizinate 0.2% 17. Ascorbic acid 2-glucoside 2.0% 18. Tranexamic acid 3.0% 19. N-stearoyl-L-glutamate sodium 0.3% 20. Diglycerin 1.0% 21. Sorbitan monoisostearate 0.1% 22. PEG-10 Glyceryl Triisostearate 0.2% 23. PEG-60 Hydrogenated Castor Oil 0.9% 24. Carboxyvinyl polymer 0.1% 25. Xanthan gum 0.01% 26. Hydrophobized hydroxypropyl methylcellulose 0.01% 27. Potassium hydroxide 0.02% 28. L-Arginine 0.01% 29. Citric acid 0.01% 30. Dipotassium phosphate 0.04% 31. Triethanolamine 0.02% 32. Ethylparaben 0.05% 33. Methylparaben 0.05% 34. Phenoxyethanol 0.5% 35,3-O-Ethyl ascorbic acid 0.01% 36. Retinyl palmitate 0.11% 37. dl-α-tocopherol nicotinate 0.5% 38. Mineral oil 8.0% 39. Octyldodecyl myristate 2.0% 40. Squalane 0.3% 41. Tri(caprylic acid, capric acid, myristic acid, stearic acid) Glyceryl glyceryl 0.5% 42. Zinc Oxide 0.5% 43. Dilinoleate Di(Phytosteryl / Isostearyl / (Cetyl / Stearyl / Behenyl) 0.3% 44. Bleached beeswax 0.1% 45. Sodium cetyl sulfate 0.02% 46. ​​Phenylentrimethicone 0.7% 47. Diphenyl Trimethicone 0.05% 48.Purified water remainder 【0052】 (Manufacturing method) Heat (19) to (35) and a portion of (48) to approximately 80°C and stir to dissolve uniformly (Solution A). Heat (36) to (47) to approximately 80°C and stir to dissolve uniformly (Solution B). Add Solution A to Solution B and disperse using a homomixer. Then cool and add (1) to (18) dissolved in the remainder of (48) at 40°C and dissolve further to dissolve uniformly. Cool again to 30°C to prepare the whitening makeup base cream. 【0053】 Prescription Example 4 (Gel Cream) (Mass %) 1. Niacinamide 6.0% 2. Cysteine ​​0.2% 3. Hot spring water 0.005% 4. Tranexamic acid 2.0% 5. Maltose-sucrose condensate 0.5% 6. Hydrolyzed elastin 1.5% 7. Glucosylceramide 0.1% 8. Methyl Gluceth-20 0.7% 9. Sodium pyrrolidone carboxylate 0.1% 10. Disodium EDTA 0.01% 11. Polyethylene glycol (molecular weight 4000) 2.0% 12. Behenyl alcohol 1.0% 13. Sodium stearoyl glutamate 0.3% 14. Carboxyvinyl polymer 0.2% 15. (Acrylates / Alkyl Acrylate) (C10-30) Crosspolymer 0.2% 16. HEDTA-3Na 0.005% 17. Citric acid 0.01% 18. Potassium hydroxide 0.22% 19. Dipropylene glycol 5.0% 20,1,3-Butylene glycol 10.0% 21. Diglycerin 0.3% 22. Glyceryl Monostearate 2.0% 23. Octyldodecyl myristate 0.5% 24. Methylpolysiloxane (6CS) 1.5% 25. Beeswax 1.0% 26. Ceramide III 0.1% 27. Sorbitan isostearate 0.2% 28.Pure water remainder 【0054】 (Manufacturing method) (9) to (21) and (28) were heated to 80°C and uniformly dissolved (Solution A). (22) to (27) were uniformly dissolved and then heated to 80°C (Solution B). Solution A was added to Solution B, dispersed using a homomixer, and then cooled to room temperature to prepare a gel cream. 【0055】 Formula Example 5 (Wrinkle Concealing Cream) (Mass %) 1. Angelica keiskei leaf / stem extract 0.07% 2. Proline 0.05% 3. Niacinamide 5.0% 4. Soybean seed extract 0.5% 5. Silk hydrolyzate 0.3% 6. Rosa multiflora fruit extract 0.0008% 7. Licorice root extract 0.09% 8. Coenzyme Q10 0.0001% 9. Red algae extract 0.45% 10. Green algae extract 0.5% 11. Saccharomyces / Rice Ferment Filtrate 0.9% 12. Ethanol 15.0% 13. Polyoxyethylene (2) alkyl (12-15) phosphoric acid 0.5% 14. Polyoxyethylene(2) oleyl ether 0.5% 15. PEG-60 Hydrogenated Castor Oil 0.5% 16. Polyvinylpyrrolidone 0.1% 17. Carboxyvinyl polymer 0.3% 18. Potassium hydroxide 0.15% 19. Disodium EDTA 0.05% 20.Fragrance 0.1% 21. Phenoxyethanol 0.2% 22. Liquid paraffin 5.0% 23. Methylpolysiloxane (100 cs) 1.0% 24. Vaseline 1.0% 25. Diphenyl Trimethicone 1.5% 26.Purified water remainder 【0056】 (Manufacturing method) Add (13) to (21) to (26) and heat to 70°C to dissolve uniformly (Solution A). Heat (22) to (25) to 60°C to disperse uniformly, add to Solution A, and disperse with a homomixer. Next, add (1) to (12) and stir, fill into tube containers, and prepare body milk. 【0057】 Formula Example 6 (Skin Texture Improving Serum) (by mass) 1. Niacinamide 4.0% 2. Soybean extract 0.2% 3. Lactobacillus / Lotus Seed Ferment Filtrate 0.01% 4. Sodium chondroitin sulfate 0.7% 5. Alanine 0.01% 6. Trimethylglycine 0.5% 7. α-Glucan Oligosaccharide 0.3% 8. Aloe vera leaf extract 0.2% 9. Hedera helix extract 0.01% 10. Elderflower Extract 0.005% 11. Parietaria extract 0.003% 12. Arnica flower extract 0.1% 13. Lactobacillus / Pear Juice Ferment Filtrate 0.1% 14. Grape leaf extract 1.0% 15. St. John's wort flower / leaf / stem extract 0.2% 16. Hamamelis Virginiana (Witch Hazel) Leaf Extract 0.6% 17. Horse Chestnut Leaf Extract 0.05% 18. Bifidobacterium culture solution 0.04% 19. Calendula Flower Extract 0.05% 20.Isomerized sugar 0.1% 21. Roman chamomile flower extract 0.0001% 22. Peach leaf extract 0.0005% 23. Cyclohexane-1,4-dicarboxylic acid Bisethoxydiglycol 0.6% 24. (Sodium acrylate / sodium acryloyldimethyl taurate) Copolymer 0.6% 25. Polyquaternium-52 0.2% 26. POE(60) Hydrogenated Castor Oil 0.1% 27,1,3-Butylene glycol 6.0% 28. Glycerin 2.0% 29. Diglycerin 0.5% 30. Polyethylene glycol 4000 1.0% 31. Sorbitol 3.0% 32. Maltitol 3.0% 33. Diisopropanolamine 0.05% 34. Potassium hydroxide 0.05% 35. Carboxyvinyl polymer 0.02% 36. Alkyl-modified carboxyvinyl polymer 0.02% 37. Xanthan gum 0.2% 38. Disodium EDTA 0.07% 39. Sodium pyrosulfite 0.05% 40. Octyldodecyl myristate 0.01% 41. Cholesterol 0.05% 42.Purified water remainder 【0058】 (Manufacturing method) (1) to (39) and (42) were uniformly dissolved at 80°C, (40) and (41) were uniformly dispersed at 80°C, and then these were added and dispersed using a homomixer, followed by cooling to prepare the beauty serum. 【0059】 Prescription Example 7 (Sunscreen) (by mass) 1. Niacinamide 4.5% 2. Yuzu fruit extract 0.2% 3. Star Fruit Extract 1.0% 4. Ethanol 5.0% 5. Dipropylene glycol 2.0% 6. Diglycerin 3.0% 7. Methoxycinnamide ethylhexyl 6.0% 8. Diethylamino hydroxybenzoyl hexyl benzoate 1.0% 9. Bis-ethylhexyloxyphenol Methoxyphenyltriazine 1.0% 10. t-Butyl methoxydibenzoylmethane 6.0% 11. Aluminum starch octenyl succinate 0.5% 12. POE·POP-modified dimethylpolysiloxane 0.8% 13. Octyldodecyl myristate 3.0% 14. Isononyl Isononanoate 1.0% 15. Methylcyclopolysiloxane 1.0% 16. Dimethylpolysiloxane 2.2% 17. Hydrogenated lecithin 0.08% 18. Phytosterols 0.08% 19. DL-α-tocopherol acetate 0.1% 20. Scutellaria Baicalensis Root Extract 0.05% 21. Green Tea Leaf Extract 0.5% 22. Angelica root extract 0.3% 23. Royal jelly extract 0.0001% 24. Water-soluble collagen 0.001% 25. Cucumber fruit extract 0.01% 26. Birch bark extract 0.1% 27. Ceramide NG 0.35% 28. Glycine 0.2% 29. Bentonite 0.1% 30. Disteardimonium hectorite 0.1% 31. Silica-coated zinc oxide 5.0% 32.Purified water remainder 【0060】 (Manufacturing method) Add (1) to (3) to (32) heated to 80°C and dissolve (Solution A). Add (5), (6), (17) to (30) and heat to 80°C to disperse uniformly (Solution B). Heat (7) to (16) to 70°C to dissolve uniformly (Solution C). Add Solution B and Solution C to Solution A in order, mix uniformly with a homomixer, and then cool to 50°C. Add (4) and (11) to this, mix further uniformly with a homomixer, and then cool to obtain the sunscreen. 【0061】 Formula Example 8 (Sheet Mask) (Mass %) 1. Niacinamide 5.0% 2. Yuzu fruit extract 0.02% 3. Peppermint leaf extract 0.01% 4. Retinyl palmitate 0.1% 5. Ascorbic acid 2-glucoside 3.0% 6. L-Ascorbic Acid Sulfate Disodium 0.1% 7. Loquat fruit extract 0.04% 8. Aminobutyric acid 0.3% 9. Job's Tears Seed Extract 0.01% 10. Lemon fruit extract 0.2% 11. Diphenylsiloxy Phenylen Trimethicone 0.8% 12. Trimethylsiloxyphenyl dimethicone 0.5% 13. Phenylentrimethicone 0.1% 14. Cyclohexane-1,4-dicarboxylic acid Bisethoxydiglycol 1.0% 15. Polyethylene glycol (average molecular weight 4000) 1.5% 16. Polyglycerin-6 3.0% 17. Methyl Gluceth-20 0.7% 18. Glycerin 3.0% 19. Dipropylene glycol 1.0% 20. Diglycerin 3.0% 21,1,3-Butylene glycol 0.5% 22. EDTA-2Na 0.01% 23. Xanthan gum 0.25% 24. Carboxyvinyl polymer 0.1% 25. Alkyl-modified carboxyvinyl polymer 0.01% 26. Hydroxyethylethylenediaminetriacetate trisodium 0.21% 27. PEG-60 Hydrogenated Castor Oil 0.1% 28. Polysorbate 20 0.2% 29. Citric acid 0.03% 30. Sodium citrate 0.03% 31.Fragrance 0.001% 32. Phenoxyethanol 0.3% 33. Hydroxyacetophenone 0.2% 34. Methylparaben 0.5% 35.Purified water remainder 【0062】 (Manufacturing method) Heat (11) to (35) to 80°C and dissolve uniformly. Then, cool to 35°C, add (1) to (10) and dissolve uniformly, then a cotton nonwoven fabric sheet (basis weight 50g / m²) 2 A sheet mask was prepared by impregnating it with 25 mL of [the solution]. 【0063】 Prescription Example 9 (Sheet Mask) (Mass %) 1. Gardenia blue extract 0.01% 2. Niacinamide 5.0% 3. Glucosyltrehalose 1.0% 4. Glycine 0.5% 5. Alaria esculenta extract 0.1% 6. Lactobacillus / Lotus Seed Ferment Filtrate 0.4% 7. Sodium glutamate 0.01% 8. Sage leaf extract 0.006% 9. Polyethylene glycol (average molecular weight 1000) 0.1% 10. Sodium polyacrylate 0.2% 11. Dipropylene glycol 10.0% 12. Diglycerin 2.0% 13. Polyoxyethylene glycerin (26 E.O.) 1.0% 14. Alkyl-modified carboxyvinyl polymer 0.1% 15. PEG-10 Glyceryl Triisostearate 0.1% 16. (PCA / Isostearate) PEG-40 Hydrogenated Castor Oil 0.1% 17. PEG-60 Hydrogenated Castor Oil 0.1% 18. Monopotassium phosphate 0.03% 19. Disodium phosphate 0.07% 20. Methylparaben 0.005% 21. Cyclohexylglycerin 0.5% 22. Squalane 0.1% 23. PEG-11 Methyl Ether Dimethicone 0.05% 24. Ethylhexyl palmitate 0.1% 25. Purified water remainder 【0064】 (Manufacturing method) Heat (1) to (21) and (25) to 80°C and stir to dissolve uniformly (Solution A). Heat (22) to (24) to 80°C and stir to disperse uniformly (Solution B). Add Solution B to Solution A and disperse in a homomixer until uniform, then cool to 30°C to form a nonwoven fabric sheet made of rayon and pulp synthetic fibers (basis weight 50g / m²). 2 A sheet mask was prepared by impregnating it with 25 mL of [the solution]. 【0065】 Formula Example 10 (Sheet Mask) (Mass %) 1. Arginine 0.05% 2. Yuzu Ceramide 0.01% 3. Glycosyltrehalose / hydrogenated starch hydrolysate mixed solution 0.1% 4. Niacinamide 4.5% 5. Scutellaria Baicalensis Root Extract 0.05% 6. Rosemary leaf extract 0.5% 7. Chamomile flower extract 0.03% 8. Japanese knotweed root extract 0.5% 9. Kiwi extract 0.06% 10. Althaea root extract 0.0007% 11. Aloe vera juice 0.0085% 12. Heparinoid 0.4% 13. Fennel fruit extract 1.0% 14. Brown algae extract 0.1% 15. Cyclohexane-1,4-dicarboxylic acid Bisethoxydiglycol 0.1% 16. Dipotassium glycyrrhizinate 0.1% 17. Ascorbic acid 2-glucoside 2.0% 18. Tranexamic acid 3.0% 19. N-stearoyl-L-glutamate sodium 0.25% 20. Diglycerin 1.0% 21. Sorbitan monoisostearate 0.1% 22. PEG-10 Glyceryl Triisostearate 0.4% 23. PEG-60 Hydrogenated Castor Oil 0.9% 24. Carboxyvinyl polymer 0.1% 25. Xanthan gum 0.04% 26. Hydrophobized hydroxypropyl methylcellulose 0.01% 27. Potassium hydroxide 0.02% 28. L-Arginine 0.01% 29. Citric acid 0.01% 30. Dipotassium phosphate 0.04% 31. Triethanolamine 0.02% 32. Ethylparaben 0.05% 33. Methylparaben 0.05% 34. Phenoxyethanol 0.5% 35,3-O-Ethyl ascorbic acid 0.01% 36. Retinyl palmitate 0.11% 37. dl-α-tocopherol nicotinate 0.5% 38. Mineral oil 8.0% 39. Octyldodecyl myristate 2.0% 40. Squalane 1.0% 41. Tri(caprylic acid, capric acid, myristic acid, stearic acid) Glyceryl glyceryl 0.5% 42. Zinc Oxide 0.5% 43. Dilinoleate Di(Phytosteryl / Isostearyl / (Cetyl / Stearyl / Behenyl) 0.3% 44. Bleached beeswax 0.1% 45. Sodium cetyl sulfate 0.02% 46. ​​Phenylentrimethicone 0.07% 47. Diphenyl Trimethicone 0.5% 48.Purified water remainder 【0066】 (Manufacturing method) Heat (19) to (35) and a portion of (48) to approximately 80°C and stir to dissolve uniformly (Solution A). Heat (36) to (47) to approximately 80°C and stir to dissolve uniformly (Solution B). Add Solution A to Solution B and disperse using a homomixer. Then cool, and add (1) to (18) dissolved in the remainder of (48) at 40°C and dissolve further to dissolve uniformly. After cooling again to 30°C, a rayon nonwoven fabric sheet (basis weight 50g / m²) is prepared. 2 A sheet mask was prepared by impregnating it with 20 mL of [the solution]. 【0067】 Formula Example 11 (Sheet Mask) (Mass %) 1. Niacinamide 6.0% 2. Cysteine ​​0.2% 3. Hot spring water 0.005% 4. Tranexamic acid 2.0% 5. Maltose-sucrose condensate 0.5% 6. Hydrolyzed elastin 0.5% 7. Glucosylceramide 0.1% 8. Methyl Gluceth-20 0.7% 9. Sodium pyrrolidone carboxylate 0.1% 10. Disodium EDTA 0.01% 11. Polyethylene glycol (molecular weight 4000) 0.6% 12. Behenyl alcohol 2.0% 13. Sodium stearoyl glutamate 0.3% 14. Carboxyvinyl polymer 0.2% 15. (Acrylates / Alkyl Acrylate) (C10-30) Crosspolymer 0.2% 16. HEDTA-3Na 0.005% 17. Citric acid 0.01% 18. Potassium hydroxide 0.22% 19. Dipropylene glycol 8.0% 20,1,3-Butylene glycol 2.0% 21. Diglycerin 0.3% 22. Glyceryl Monostearate 2.0% 23. Octyldodecyl myristate 0.5% 24. Methylpolysiloxane (6CS) 0.2% 25. Beeswax 0.5% 26. Ceramide III 0.01% 27. Sorbitan isostearate 0.2% 28.Pure water remainder 【0068】 (Manufacturing method) (9)~(21) and (28) were heated to 80°C and uniformly dissolved (Solution A). (22)~(27) were uniformly dissolved and then heated to 80°C (Solution B). Solution A was added to Solution B, dispersed using a homomixer, and then cooled to room temperature. After that, a cupro nonwoven fabric sheet (basis weight 50g / m²) was prepared. 2 A sheet mask was prepared by impregnating it with 25 mL of [the solution]. 【0069】 Formula Example 12 (Sheet Mask) (Mass %) 1. Angelica keiskei leaf / stem extract 0.07% 2. Proline 0.05% 3. Niacinamide 5.0% 4. Soybean seed extract 0.5% 5. Silk hydrolyzate 0.3% 6. Rosa multiflora fruit extract 0.0008% 7. Licorice root extract 0.09% 8. Coenzyme Q10 0.01% 9. Red algae extract 0.45% 10. Green algae extract 0.05% 11. Saccharomyces / Rice Ferment Filtrate 0.9% 12. Ethanol 15.0% 13. Polyoxyethylene (2) alkyl (12-15) phosphoric acid 0.5% 14. Polyoxyethylene(2) oleyl ether 0.5% 15. PEG-60 Hydrogenated Castor Oil 0.5% 16. Polyvinylpyrrolidone 0.1% 17. Carboxyvinyl polymer 0.3% 18. Potassium hydroxide 0.15% 19. Disodium EDTA 0.05% 20.Fragrance 0.1% 21. Phenoxyethanol 0.2% 22. Liquid paraffin 5.0% 23. Methylpolysiloxane (100 cs) 1.0% 24. Vaseline 1.0% 25. Diphenyl Trimethicone 1.5% 26.Purified water remainder 【0070】 (Manufacturing method) Add (13) to (21) to (26) and heat to 70°C to dissolve uniformly (Solution A). Heat (22) to (25) to 60°C to disperse uniformly, add to Solution A, and disperse with a homomixer. Next, add (1) to (12) and stir to make a pulp nonwoven fabric sheet (basis weight 50g / m²). 2 A sheet mask was prepared by impregnating it with 25 mL of [the solution]. 【0071】 Formula Example 13 (Sheet Mask) (Mass %) 1. Niacinamide 4.0% 2. Soybean extract 0.2% 3. Lactobacillus / Lotus Seed Ferment Filtrate 0.01% 4. Sodium chondroitin sulfate 0.7% 5. Alanine 0.01% 6. Trimethylglycine 0.5% 7. α-Glucan Oligosaccharide 0.3% 8. Aloe vera leaf extract 0.2% 9. Hedera helix extract 0.01% 10. Elderflower Extract 0.005% 11. Parietaria extract 0.3% 12. Arnica flower extract 0.1% 13. Lactobacillus / Pear Juice Ferment Filtrate 0.1% 14. Grape leaf extract 1.0% 15. St. John's wort flower / leaf / stem extract 0.2% 16. Hamamelis Virginiana (Witch Hazel) Leaf Extract 0.6% 17. Horse Chestnut Leaf Extract 0.05% 18. Bifidobacterium culture solution 0.04% 19. Calendula Flower Extract 0.05% 20.Isomerized sugar 0.1% 21. Roman chamomile flower extract 0.0001% 22. Peach leaf extract 0.0005% 23. Cyclohexane-1,4-dicarboxylic acid Bisethoxydiglycol 0.1% 24. (Sodium acrylate / sodium acryloyldimethyl taurate) Copolymer 0.6% 25. Polyquaternium-52 0.2% 26. POE(60) Hydrogenated Castor Oil 0.1% 27.1,3-Butylene glycol 2.0% 28. Glycerin 2.0% 29. Diglycerin 0.5% 30. Polyethylene glycol 4000 1.0% 31. Sorbitol 1.0% 32. Maltitol 3.0% 33. Diisopropanolamine 0.05% 34. Potassium hydroxide 0.05% 35. Carboxyvinyl polymer 0.02% 36. Alkyl-modified carboxyvinyl polymer 0.02% 37. Xanthan gum 0.1% 38. Disodium EDTA 0.07% 39. Sodium pyrosulfite 0.05% 40. Octyldodecyl myristate 0.5% 41. Cholesterol 0.5% 42.Purified water remainder 【0072】 (Manufacturing method) Dissolve (1) to (39) and (42) uniformly at 80°C, add (40) and (41) to a uniformly dispersed mixture at 80°C, disperse in a homomixer, then cool to form a cotton nonwoven fabric sheet (basis weight 50g / m²). 2 A sheet mask was prepared by impregnating it with 25 mL of [the solution]. 【0073】 Prescription Example 14 (Sheet Mask) (Mass %) 1. Niacinamide 4.5% 2. Yuzu fruit extract 0.2% 3. Star Fruit Extract 1.0% 4. Ethanol 2.0% 5. Dipropylene glycol 2.0% 6. Diglycerin 1.0% 7. Methoxycinnamide ethylhexyl 6.0% 8. Diethylamino hydroxybenzoyl hexyl benzoate 1.0% 9. Bis-ethylhexyloxyphenol Methoxyphenyltriazine 1.0% 10. t-Butyl methoxydibenzoylmethane 6.0% 11. Aluminum starch octenyl succinate 0.5% 12. POE·POP-modified dimethylpolysiloxane 0.8% 13. Octyldodecyl myristate 3.0% 14. Isononyl Isononanoate 1.0% 15. Methylcyclopolysiloxane 1.0% 16. Dimethylpolysiloxane 2.2% 17. Hydrogenated lecithin 0.08% 18. Phytosterols 0.08% 19. DL-α-tocopherol acetate 0.1% 20. Scutellaria Baicalensis Root Extract 0.05% 21. Green Tea Leaf Extract 0.5% 22. Angelica root extract 0.3% 23. Royal jelly extract 0.0001% 24. Water-soluble collagen 0.001% 25. Cucumber fruit extract 0.01% 26. Birch bark extract 0.1% 27. Ceramide NG 0.35% 28. Glycine 0.2% 29. Bentonite 0.1% 30. Disteardimonium hectorite 0.1% 31. Silica-coated zinc oxide 5.0% 32.Purified water remainder 【0074】 (Manufacturing method) Add (1) to (3) heated to 80°C and dissolve (Solution A). Add (5), (6), (17) to (30) and heat to 80°C to disperse uniformly (Solution B). Heat (7) to (16) to 70°C to dissolve uniformly (Solution C). Add Solution B and Solution C to Solution A in order, mix uniformly with a homomixer, then cool to 50°C. Add (4) and (11) to the mixture, mix further uniformly with a homomixer, then cool to form a cupro nonwoven fabric sheet (basis weight 50g / m²). 2 A sheet mask was prepared by impregnating it with 30 mL of [the solution].

Claims

[Claim 1] A topical skin preparation containing the following (A) to (C). (A) Niacinamide 0.1-6% by mass (B) Diglycerin 0.1-4% by mass (C) One or more amino acids and their salts selected from 0.0001 to 0.5% by mass [Claim 2] A topical skin preparation according to claim 1, comprising the following (D). (D) One or more extracts or fermented products selected from yuzu, soybeans, lotus, royal jelly, and scutellaria baicalensis, in a quantity of 0.0001 to 0.5% by mass.