Liquid oral components

Abstract

The present invention aims to provide a liquid oral composition that can suppress the reduction in flavor expression caused by glycyrrhizic acid or its salts by incorporating acyl amino acids or their salts. [Solution] A liquid oral composition comprising: (A) component: at least one selected from the group consisting of glycyrrhizic acid and its salts; (B) component: at least one selected from the group consisting of acyl amino acids and their salts; and (C) component: a fragrance, wherein the ratio of the content of component (A) to the content of component (B) is 0.625 to less than 2.2 when component (B) contains acyl sarcosine and its salts, and 0.03 to less than 5 when component (B) does not contain acyl sarcosine and its salts, and substantially free of ethyl alcohol.

Description

Technical Field

[0006] ,

[0001] The present invention relates to a liquid oral composition.

Background Art

[0002] Glycyrrhizic acid or its salts, such as dipotassium glycyrrhizinate (GK2), have an anti-inflammatory effect, and when formulated in an oral composition, they can enhance the effect of preventing periodontal disease while giving a sweet taste feeling. Therefore, they have been formulated in oral compositions (for example, Patent Documents 1 to 3).

Prior Art Documents

Patent Documents

[0003]

Patent Document 1

Patent Document 2

Patent Document 3

Summary of the Invention

Problems to be Solved by the Invention

[0004] However, when glycyrrhizic acid or its salts are formulated in a liquid oral composition that does not contain ethyl alcohol (has no alcohol odor), there is a problem that the expression of the fragrance due to the fragrance in the liquid oral composition may be reduced (it becomes difficult to feel the fragrance).

[0005] An object of the present invention is to provide a liquid oral composition that is substantially free of ethyl alcohol and has good fragrance expression even when containing glycyrrhizic acid and / or its salts.

Means for Solving the Problems

[0006] As a result of various investigations into means of solving this problem, we found that by incorporating acyl amino acids or their salts in a specific proportion, the reduction in flavor expression caused by glycyrrhizic acid or its salts can be suppressed.

[0007] The present invention provides the following [1] to [6]. [1] A liquid oral composition comprising (A) component: at least one selected from the group consisting of glycyrrhizic acid and its salts, (B) component: at least one selected from the group consisting of acyl amino acids and their salts, and (C) component: a fragrance, wherein the ratio of the content of component (A) to the content of component (B) is 0.625 to less than 2.2 when component (B) contains acyl sarcosine and its salts, and 0.03 to less than 5 when component (B) does not contain acyl sarcosine and its salts, and substantially free of ethyl alcohol. [2] The composition according to [1], wherein component (B) is at least one selected from the group consisting of acylmethyltaurine, acylmethylalanine, acylglutamic acid, acylsarcosine, and salts thereof. [3] The liquid oral composition according to [1] or [2], wherein component (A) is at least one of dipotassium glycyrrhizinate and monoammonium glycyrrhizinate. [4] A composition according to any one of items [1] to [3], wherein the content of component (A) is 0.005 to 1.5% by mass. [5] A composition according to any one of items [1] to [4], wherein the content of component (B) is 0.01 to 1% by mass. [6] The composition according to any one of [1] to [5], wherein component (C) is at least one selected from the group consisting of menthol, carvone, 1,8-cineole, anethole, cinnamic aldehyde, eugenol, methyl salicylate, thymol, and limonene. [Effects of the Invention]

[0008] According to the present invention, by including acyl amino acids or salts thereof, the reduction in flavor expression caused by glycyrrhizic acid or salts thereof can be suppressed. Furthermore, according to the present invention, oral irritation caused by acyl amino acids or salts thereof can be suppressed by glycyrrhizic acid or salts thereof. [Modes for carrying out the invention]

[0009] [1. Liquid oral composition of the present invention] The liquid oral composition of the present invention contains component (A), component (B), and component (C), and substantially does not contain ethyl alcohol.

[0010] [(A) component] (A) Component is at least one selected from the group consisting of glycyrrhizic acid and its salts. Component (A) can suppress oral irritation caused by component (B).

[0011] Examples of glycyrrhizinate salts include alkali metals such as sodium salts and potassium salts, and ammonium salts, with potassium salts and ammonium salts being preferred, and potassium salts being more preferred. More specifically, examples include dipotassium glycyrrhizinate, disodium glycyrrhizinate, trisodium glycyrrhizinate, and monoammonium glycyrrhizinate. Of these, dipotassium glycyrrhizinate and monoammonium glycyrrhizinate are preferred, and dipotassium glycyrrhizinate is more preferred. By including component (A), oral irritation caused by component (B) can be suppressed.

[0012] Glycyrrhizic acid and its salts may be derived from natural raw materials such as plants, or they may be manufactured industrially. Component (A) may be, for example, a single component selected from glycyrrhizic acid and its salts, or a combination of two or more components that differ in type, raw materials, and manufacturing method.

[0013] -(A) Content of component- The content of component (A) is preferably 0.005% by mass or more, or 0.01% by mass or more, more preferably 0.012% by mass or more, and even more preferably 0.013% by mass or more, based on the total amount of the composition of the present invention. This makes it possible to suppress oral irritation derived from component (B). The upper limit is preferably 1.5% by mass or less, or 0.9% by mass or less, more preferably 0.4% by mass or less, and even more preferably 0.15% by mass or less. This prevents excessive reduction in flavor expression and allows for good flavor expression. Therefore, it is preferably 0.005 to 1.5% by mass, or 0.01 to 0.9% by mass, more preferably 0.012 to 0.4% by mass, and even more preferably 0.013 to 0.15% by mass.

[0014] [(B) Component] Component (B) is at least one selected from the group consisting of acyl amino acids and their salts. Component (B) can suppress the reduction in flavor expression caused by component (A).

[0015] Acyl amino acids and their salts have a hydrocarbon group as a lipophilic group. Typically, a part of the structure derived from fatty acid acyls and / or amino acids is a hydrocarbon group as a lipophilic group. The number of carbon atoms in the hydrocarbon group is usually 8 to 20, preferably 10 to 18, and more preferably 11 to 16. The hydrocarbon group may be saturated or unsaturated, with saturated being preferred. The hydrocarbon group may be linear, branched, or cyclic, preferably linear or branched, and more preferably linear.

[0016] The salt can be selected from pharmaceutically acceptable salts. Examples of pharmaceutically acceptable salts include, for example, base addition salts and amino acid salts. Specific examples thereof include inorganic base salts such as sodium salt, potassium salt, calcium salt, magnesium salt, ammonium salt, etc.; organic base salts such as triethylammonium salt, triethanolammonium salt, pyridinium salt, diisopropylammonium salt, etc.; and basic amino acid salts such as arginine salt. Among them, inorganic base salts are preferred, alkali metal salts (for example, sodium salt, potassium salt) or ammonium salt are more preferred, and sodium salt is even more preferred.

[0017] The acyl group of the acyl amino acid may be either linear or branched, and may be either saturated or unsaturated. The number of its carbon atoms is usually 8 - 20, preferably 10 - 18, and more preferably 12 - 14. More specifically, for example, octanoyl group, nonanoyl group, decanoyl group, undecanoyl group, lauroyl group, tridecanoyl group, myristoyl group, pentadecanoyl group, palmitoyl group can be mentioned.

[0018] Examples of the amino acid in the acyl amino acid include, for example, glycine, alanine, glutamic acid, valine, leucine, isoleucine, serine, threonine, cysteine, methionine, aspartic acid, glutamine, proline, phenylalanine, tyrosine, tryptophan, taurine, etc. The hydrogen of the amino group or imino group of these amino acids may be substituted with an alkyl group (for example, methyl group). Examples of such amino acid derivatives include N - methylalanine, N - methylglycine (sarcosine), N - methylglutamic acid, and N - methyltaurine.

[0019] Examples of the acyl amino acid and its salt include, for example, acyl taurine, acyl alanine, acyl glutamic acid, acyl sarcosine, acyl glycine, acyl aspartic acid, and salts thereof. Examples of acyltaurine include acylmethyltaurines such as lauroylmethyltaurine and cocoylmethyltaurine. Examples of acylalanine include acylmethylalanines such as lauroylmethylalanine, myristoylmethylalanine, and methylacylalanine, lauroylalanine, myristylalanine, and cocoylalanine. Examples of acylglutamic acid include lauroylglutamic acid, myristoylglutamic acid, and palmitoylglutamic acid. Examples of acylsarcosine include lauroylsarcosine and myristoylsarcosine. Examples of acylglycine include lauroylmethylglycine and cocoylglycine. Examples of acylaspartic acid include lauroylaspartic acid.

[0020] Among these, the component (B) is preferably acylmethyltaurine, acylmethylalanine, acylglutamic acid, acylsarcosine, and salts thereof, more preferably lauroylmethyltaurine salt, lauroylmethylalanine salt, lauroylglutamic acid salt, myristoylglutamic acid salt, and lauroylsarcosine salt, still more preferably sodium lauroylmethyltaurine, sodium lauroylsarcosine, sodium lauroylmethylalanine, sodium lauroylglutamic acid, and sodium myristoylglutamic acid, and even more preferably sodium lauroylmethyltaurine and sodium lauroylsarcosine.

[0021] The content of component (B) is preferably 0.01% by mass or more, or 0.03% by mass or more, more preferably 0.08% by mass or more, and even more preferably 0.13% by mass or more, based on the total amount of the composition of the present invention. This can improve the expression of flavor. The upper limit is preferably 1% by mass or less, or 0.5% by mass or less, more preferably 0.3% by mass or less, and even more preferably 0.24% by mass or less. This can prevent oral irritation caused by component (B). Therefore, the content of component (B) is preferably 0.01 to 1% by mass or 0.03 to 0.5% by mass, more preferably 0.08 to 0.3% by mass, and even more preferably 0.13 to 0.24% by mass, based on the total amount of the composition of the present invention.

[0022] [Ratio (A) / (B)] The ratio of the content of component (A) to the content of component (B) (hereinafter, (A) / (B)) is, for example, 0.03 to less than 5.

[0023] If component (B) contains acyl sarcosine and its salts, the ratio (A) / (B) is preferably 0.625 or higher, more preferably 0.65 or higher, even more preferably 0.7 or higher, or 0.75 or higher. Its upper limit is preferably less than 2.2, more preferably 2.1 or lower, and even more preferably 2 or lower. This makes it possible to suppress the decrease in flavor expression while preventing oral irritation caused by component (B). Therefore, it is preferably between 0.625 and less than 2.2, and if component (B) contains acyl sarcosine and its salts, the ratio (A) / (B) is more preferably between 0.65 and 2.1, even more preferably 0.7 and 2, or 0.75 and 2.

[0024] If component (B) does not contain acyl sarcosine and its salts, the ratio (A) / (B) is preferably 0.03 or higher, more preferably 0.055 or higher, or 0.06 or higher, and even more preferably 0.065 or higher. The upper limit is preferably less than 5, or 4.9 or lower, more preferably 3 or lower, or 2.4 or lower, and even more preferably 2 or lower. This makes it possible to suppress the decrease in flavor expression while preventing oral irritation caused by component (B). Therefore, if component (B) does not contain acyl sarcosine and its salts, the ratio (A) / (B) is preferably 0.03 to less than 5, or 0.03 to 4.9, more preferably 0.055 to 3, or 0.06 to 2.4, and even more preferably 0.065 to 2.

[0025] [(C) component] (C) component is a fragrance. By containing (C) component, the composition of the present invention can express its flavor well. Examples of fragrances include natural essential oils such as peppermint oil, spearmint oil, Japanese mint oil, anise oil, cassia oil, clove oil, eucalyptus oil, wintergreen oil, mastic oil, neroli oil (orange blossom oil), lemongrass oil, jasmine oil, rose oil, iris oil, thyme oil, sage oil, cardamom oil, coriander oil, rosemary oil, laurel oil, chamomile oil, caraway oil, basil oil, marjoram oil, lemon oil, orange oil, grapefruit oil, lime oil, mandarin oil, yuzu oil, nutmeg oil, lavender oil, paracleth oil, vanilla oil, cinnamon oil, pimento oil, cinnamon leaf oil, and perilla oil; menthol, menthofran, carvone, cinnamic aldehyde, anethole, 1,8-cineole, methyl salicylate Fragrance components contained in the above natural essential oils, such as phosphate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, decanal, camphor, borneol, pinene, spiranthol, n-decyl alcohol, citronellol, α-terpineol, linalyl acetate, phenylethyl glycidate, phenylethyl alcohol, allyl hexanoate, octanol, octanal, octyl acetate, caryophyllene, germacrene, viridiflorol, methyl cinnamate, methylheptin carbonate, ionone, ethyl-β-methylthiopropionate, cis-6-nonenol, carone, methyl jasmonate, citronellyl acetate, ethyl linalool, etc.Ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methylphenyl glycidate, benzaldehyde, vanillin, ethyl vanillin, furaneol, ethylcyclopentenolone, 3-hydroxy-4,5-dimethylfuran-2-one, cyclotene, 2-methylbutyric acid, acetate acid, propionic acid, cis-3-hexenol, trans-2-hexenal, undecalact Fragrance components such as decalactone, hexyl acetate, ethyl-2-methyl butyrate, benzyl alcohol, N-ethyl-p-menthane-3-carboxamide (N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide), menthyl lactate, ethylene glycol-l-menthyl carbonate, maltol, ethyl maltol; plant extracts such as vanilla extract, chili pepper extract, ginger extract, pepper extract, Japanese pepper extract, cardamom extract;This also includes various blended flavors such as mint, fruit, and herb, which are created by combining several fragrance components and natural essential oils. Furthermore, fragrances that can also function as cooling agents include, for example, N-ethyl-p-menthane-3-carboxamide (N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide), N-((ethoxycarbonyl)methyl)-p-menthane-3-carboxamide, Np-benzeneacetonitrile menthanecarboxamide, N-(2-(pyridine-2-yl)ethyl)-3-p-menthanecarboxamide, N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide, 2-(4-methylphenoxy)-N-(1H-pyrazole-3-yl)-N-(thiophen-2-ylmethyl)acetamide, menthyl lactate, menthyl monosuccinate, vanillyl butyl ether, isopulegol, menthol glycoside ketal, N-(4-cyanomethylphenyl)- Other examples include p-menthanecarboxamide, 3-l-menthoxypropane-1,2-diol, menthyl glyceryl ether, menthyl succinate, linalool oxide, vanillyl butyl ether, 5-methyl-2-propane-2-yl-N-(2-pyridine-2-ylethyl)cyclohexane-1-carboxamide, 3-(p-menthane-3carboxamide)ethyl acetate, 2-isopropyl-N,2,3-trimethylbutylamide, N-ethyl-2,2-diisopropylbutanamide, N-(1,1-dimethyl-2-hydroxyethyl)-2,2-diethylbutanamide, N-(2-hydroxyethyl)-2,3-dimethyl-2-isopropylbutanamide, menthyl glutarate, 2-(4-methylphenoxy)-N-(1H-pyrazole-yl)-N-(thiophen-2-ylmethyl)acetamide, and isopulegol. As for the fragrance, one of the fragrances exemplified above may be used alone, or two or more may be used in combination.

[0026] Of these, menthol, carvone, 1,8-cineole, anethole, cinnamic aldehyde, eugenol, methyl salicylate, thymol, and limonene are preferred, menthol, carvone, 1,8-cineole, anethole, cinnamic aldehyde, eugenol, and methyl salicylate are more preferred, and menthol is even more preferred. Including these fragrances as component (C) is preferable because it allows for a greater perception of the fragrance derived from the fragrance and improves flavor expression.

[0027] (C) Component may be one of the above components alone, or a combination of two or more components of different types, raw materials, or manufacturing methods, but it is more preferable to include a combination of two or more, three or more, or four or more components selected from the group consisting of menthol, carvone, 1,8-cineole, anethole, cinnamic aldehyde, eugenol, methyl salicylate, thymol, and limonene. Preferred such combinations include menthol and carvone, menthol and cineole, menthol and anethole, menthol and cinnamic aldehyde, menthol and eugenol, menthol and methyl salicylate, menthol and thymol, and menthol and limonene, and combinations of menthol, 1,8-cineole and anethole, menthol, anethole and cinnamic aldehyde, and menthol, carvone and cinnamic aldehyde. More preferably, a combination of menthol, carvone, and methyl salicylate, and a combination of menthol, cinnamic aldehyde, and methyl salicylate are preferred, and a combination of menthol, carvone, cinnamic aldehyde, and methyl salicylate is even more preferred, and a combination of menthol, carvone, 1,8-cineole, anethole, cinnamic aldehyde, eugenol, and methyl salicylate is even more preferred, and a combination of menthol, carvone, 1,8-cineole, anethole, cinnamic aldehyde, eugenol, methyl salicylate, thymol, and limonene is even more preferred. By including the above fragrance combinations in component (C), the reduction in flavor expression caused by component (A) is suppressed by component (B), thereby allowing the flavor to be more fully expressed and the remarkable effects of the present invention to be more favorably exhibited.

[0028] The content of component (C) is preferably 0.000001% by mass or more, more preferably 0.01% by mass or more, or 0.1% by mass or more, relative to the total amount of the composition of the present invention. The upper limit is preferably 2% by mass or less, more preferably 1% by mass or less, or 0.5% by mass or less. Therefore, the content of component (C) is preferably 0.000001 to 2% by mass, more preferably 0.01 to 1% by mass, or 0.1 to 0.5% by mass, relative to the total amount of the composition of the present invention.

[0029] The total amount of at least one fragrance selected from the group consisting of menthol, carvone, 1,8-cineole, anethole, cinnamic aldehyde, eugenol, methyl salicylate, thymol, and limonene is preferably 5% by mass or more, more preferably 7% by mass or more, and even more preferably 10% by mass or more, relative to the total amount of component (C). The upper limit is preferably 100% by mass or less, more preferably 95% by mass or less, and even more preferably 90% by mass or less. Therefore, the total amount of at least one fragrance selected from the group consisting of menthol, carvone, 1,8-cineole, anethole, cinnamic aldehyde, eugenol, methyl salicylate, thymol, and limonene is preferably 5 to 100% by mass, more preferably 7 to 95% by mass, and even more preferably 10 to 90% by mass, relative to the total amount of component (C).

[0030] If component (C) contains menthol, the menthol content is preferably 0.1 to 70% by mass, or 1 to 70% by mass, more preferably 3 to 60% by mass, relative to the total amount of component (C). If component (C) contains carvone, the carvone content is preferably 0.1 to 30% by mass, and more preferably 0.5 to 25% by mass, relative to the total amount of component (C). If component (C) contains 1,8-cineole, the 1,8-cineole content is preferably 0.1 to 30% by mass, and more preferably 0.5 to 25% by mass, relative to the total amount of component (C). If component (C) contains anethole, the anethole content is preferably 0.1 to 30% by mass, and more preferably 0.5 to 25% by mass, relative to the total amount of component (C). If component (C) contains cinnamic aldehyde, the cinnamic aldehyde content is preferably 0.1 to 30% by mass, and more preferably 0.5 to 25% by mass, relative to the total amount of component (C). If component (C) contains eugenol, the eugenol content is preferably 0.1 to 20% by mass, and more preferably 0.5 to 15% by mass, relative to the total amount of component (C). If component (C) contains methyl salicylate, the methyl salicylate content is preferably 0.1 to 40% by mass, and more preferably 0.5 to 35% by mass, relative to the total amount of component (C).

[0031] Furthermore, solvents may be used when compounding these fragrances. Examples of solvents include propylene glycol, glycerin fatty acid esters, and triacetin. The solvent can be used as long as the composition of the present invention does not substantially contain ethyl alcohol. "Substantially containing ethyl alcohol" is as described below.

[0032] The liquid oral composition of the present invention is substantially free of ethyl alcohol. As a result, the flavor expression of component (C) is more favorably exhibited because component (B) suppresses the reduction in flavor expression caused by component (A). In the present invention, "substantially free of ethyl alcohol" means that the ethyl alcohol content in the composition of the present invention is preferably less than 0.01% by mass, more preferably 0.001% by mass or less, even more preferably below the detection limit, or either zero or zero by mass.

[0033] [Optional ingredients] The liquid oral composition of the present invention may contain, as appropriate, known components in addition to the above components (A) to (C), depending on the dosage form and intended use described later. Examples include surfactants, thickeners, preservatives, sweeteners, wetting agents, pH adjusters, suspending agents, colorants, active ingredients, solvents, and oily components. When the liquid oral composition of the present invention is a mouthwash, it does not usually contain non-solubilizable solid components such as abrasives.

[0034] Examples of surfactants include nonionic surfactants, amphoteric surfactants, and anionic surfactants.

[0035] Examples of nonionic surfactants include polyoxyethylene alkyl ethers (e.g., polyoxyethylene cetyl ether), polyoxyethylene hydrogenated castor oil, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters (e.g., polyoxyethylene sorbitan monostearate), alkylolamides, polyoxyethylene fatty acid esters, polyoxyethylene alkenyl ethers, glycerin fatty acid esters (e.g., triglycerides such as tri(caprylic / capric acid) glyceryl), polyglycerin fatty acid esters, alkyl glycosides, sucrose fatty acid esters (e.g., maltose fatty acid esters), sugar alcohol fatty acid esters (e.g., maltitol fatty acid esters, lactitol fatty acid esters), fatty acid ethanolamides (e.g., lauric acid mono or diethanolamide), polyoxyethylene-polyoxypropylene copolymers, polyoxyethylene-polyoxypropylene fatty acid esters, and polyoxyethylene-polyoxypropylene alkyl ethers. The number of carbon atoms in the alkyl chain of polyoxyethylene alkyl ether is typically 10 to 26, and the average number of moles of ethylene oxide added is typically 2 to 50 moles. The average number of moles of ethylene oxide added to polyoxyethylene hydrogenated castor oil is typically 5 to 100 moles, preferably 20 to 100 moles. The number of carbon atoms in the fatty acid of sorbitan fatty acid ester is typically 10 to 18. The number of carbon atoms in the fatty acid of polyoxyethylene sorbitan fatty acid ester is typically 12 to 18, and the average number of moles of ethylene oxide added is typically 20 to 80 moles. The number of carbon atoms in the alkyl chain of alkylolamide is typically 12 to 14. The number of carbon atoms in the alkyl chain of polyoxyethylene polyoxypropylene alkyl ether is typically 10 to 20, the average number of moles of ethylene oxide added is typically 10 to 300 moles, and the average number of moles of propylene oxide added is typically 5 to 70 moles. Polyoxyethylene hydrogenated castor oil is preferred as a nonionic surfactant.

[0036] Examples of amphoteric surfactants include betaine-type amphoteric surfactants such as alkyldimethylaminoacetic acid betaine (e.g., lauryldimethylaminoacetic acid betaine) and fatty acid amidopropyldimethylaminoacetic acid betaine (e.g., coconut oil fatty acid amidopropyl betaine, cocamidopropyl betaine); imidazoline-type amphoteric surfactants such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salts (e.g., N-coconut oil fatty acid acyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine), coconut oil fatty acid imidazolinium betaine, and 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine; and alkylbetaines such as lauryldimethylaminoacetic acid betaine.

[0037] Examples of anionic surfactants include alkyl sulfates, α-olefin sulfonates, hydrogenated coconut fatty acid monoglyceride monosulfates, and alkyl sulfoacetates. When an alkyl group is present, the alkyl group may be linear or branched, saturated or unsaturated, and its number of carbon atoms is usually 10 to 20, preferably 12 to 18. The salt can be selected from pharmacokinetically acceptable salts. Examples of pharmacokinetically acceptable salts include inorganic base salts such as sodium salts, potassium salts, calcium salts, magnesium salts, and ammonium salts; organic base salts such as triethylammonium salts, triethanolammonium salts, pyridinium salts, and diisopropylammonium salts; and basic amino acid salts such as arginine salts, lysine salts, and histidine salts. Among these, inorganic base salts are preferred, alkali metal salts (e.g., sodium salts, potassium salts) or ammonium salts are more preferred, and sodium salts are even more preferred.

[0038] Examples of alkyl sulfates include lauryl sulfate (e.g., sodium lauryl sulfate) and myristoyl sulfate. Examples of α-olefin sulfonates include α-olefin sulfonates with 12 to 14 carbon atoms, such as tetradecene sulfonate. Other examples of anionic surfactants include hydrogenated coconut fatty acid monoglyceride monosulfate sodium and sodium lauryl sulfoacetate.

[0039] When the liquid oral composition of the present invention contains the above-mentioned surfactant, the total content of the surfactant is preferably 0.05 to 2.0% by mass, more preferably 0.1 to 1.5% by mass.

[0040] Examples of thickening agents include cellulosic compounds such as sodium carboxymethylcellulose, and gums such as xanthan gum and carrageenan. When the liquid oral composition of the present invention contains a thickening agent, its content is usually 0.001 to 3% by mass.

[0041] Examples of preservatives include parahydroxybenzoic acid esters (e.g., methyl parahydroxybenzoate, ethyl parahydroxybenzoate), benzoic acid, or its sodium salt.

[0042] Examples of sweeteners include sodium saccharin, sucralose, mannitol, aspartame, stevioside, stevia extract, p-methoxycinnamic aldehyde, neohesperidin dihydrochalcone, perillartin, thaumatin, and aspartylphenylalanine methyl ester. When using sweeteners, the amount can be appropriately determined within a range that does not impair the effects of the present invention.

[0043] Examples of humectants include polyhydric alcohols. Examples of polyhydric alcohols include sugar alcohols such as sorbitol, erythritol, maltitol, lactitol, and xylitol; glycerin; glycols such as ethylene glycol, polyethylene glycol (molecular weight 200-6000), propylene glycol, and dipropylene glycol; and reduced starch saccharides.

[0044] Examples of pH adjusting agents include phthalic acid, citric acid, malic acid, lactic acid, tartaric acid, succinic acid, acetic acid, phosphoric acid, pyrophosphate, glycerophosphate, various salts of these such as calcium salts, potassium salts, sodium salts, and ammonium salts, sodium hydroxide, and hydrochloric acid. These can be blended individually or in combination of two or more to achieve a pH of 5 to 9 in the composition. When using pH adjusting agents, the amount blended can be appropriately determined within a range that does not impair the effects of the present invention.

[0045] A premixed emulsion can be used as a suspending agent. The oily component contained in the emulsion particles consists of oils and fats that are liquid at 25°C. This emulsion can be an O / W type (oil-in-water) emulsion obtained by emulsifying the oily component with an emulsifier using a polyhydric alcohol such as glycerin or water as a dispersion medium. It is preferable to add and blend such an O / W type emulsion. In this case, the oil droplet particles of the O / W type emulsion are dispersed in the liquid oral composition, and the dispersion medium mixes with the aqueous phase of the liquid oral composition, resulting in the existence of an O / W type emulsion.

[0046] Examples of oily components that are liquid at 25°C include liquid oils such as olive oil, camellia oil, and castor oil, as well as triglycerides with a carbon chain length of 6 to 12. These can be used individually or in combination of two or more. Commercially available oily components can also be used. Examples of triglycerides include glyceryl tricaprylate, glyceryl tricaprate, and tri(caprylic / capric acid)glyceride. The amount of triglycerides blended into the emulsion is preferably 10 to 60% by mass, particularly 20 to 50% by mass.

[0047] As emulsifiers, one or more nonionic surfactants such as glycerin fatty acid esters, polyoxyethylene hydrogenated castor oil, and polyoxyethylene alkyl ethers can be used, with HLB values ​​of 10 to 16 being preferred. Examples of glycerin fatty acid esters include decaglyceryl monomyristate and decaglyceryl monolaurate, which are decaglycerin monofatty acid esters with 12 to 16 fatty acid carbon atoms. The average number of moles of ethylene oxide added from polyoxyethylene hydrogenated castor oil is 10 to 100 moles, particularly 20 to 60 moles, and especially 20 moles. The average number of moles of ethylene oxide added from polyoxyethylene alkyl ethers is 4 to 20 moles, particularly 6 to 15 moles. Among these, decaglyceryl monomyristate and polyoxyethylene hydrogenated castor oil are particularly preferred. One or more of the above can be used as emulsifiers. Commercially available emulsifiers can also be used. The amount of emulsifier added is usually preferably 5 to 30% by mass of the total emulsion, including the dispersion medium, and more preferably 5 to 20% by mass.

[0048] As a dispersion medium, in addition to water, one or more polyhydric alcohols such as glycerin, dipropylene glycol, propylene glycol, 1,3-butylene glycol, and polyethylene glycol with an average molecular weight of 190 to 630 can be used. Commercially available dispersion media may also be used.

[0049] The above emulsion preferably has an average particle size of 30 to 300 nm, particularly 40 to 150 nm, and especially 40 to 120 nm. The suspension may be one of the above-mentioned types used alone, or two or more types used in combination, or a commercially available product may be used.

[0050] As colorants, water-soluble dyes are preferred due to their high safety. Examples include Blue No. 1, Green No. 3, Yellow No. 4, and Red No. 105.

[0051] The pH of the liquid oral composition of the present invention is preferably 5 or higher, more preferably 5.5 or higher, at 25°C. This effectively suppresses gelation of the liquid oral composition of the present invention. The upper limit is preferably 8 or lower, more preferably 7.5 or lower, at 25°C. This results in better appearance stability. Therefore, the pH of the liquid oral composition of the present invention is preferably 5 to 8, more preferably 5.5 to 7.5, at 25°C. For pH adjustment, a combination of sodium dihydrogen phosphate and sodium monohydrogen phosphate, or citric acid and sodium citrate, may be included as a pH adjuster.

[0052] Active ingredients include, for example, bactericidal or antibacterial agents such as cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, zinc gluconate, zinc citrate, chlorhexidine hydrochloride, triclosan, hinokitiol, and isopropylmethylphenol; enzymes such as dextranase, mutanase, amylase, protease, and Ritec enzyme; fluorides such as sodium fluoride, potassium fluoride, sodium monofluorophosphate, and tin fluoride; anti-inflammatory agents such as ε-aminocaproic acid, allantoin, tranexamic acid, aluminum chlorohydroxyallantoin, azulene, sodium azulene sulfonate, dihydrocholesterol, Phellodendron amurense, and Phellodendron amurense extract; metal salts such as zinc, copper salts, and tin salts; condensed phosphates such as sodium polyphosphate and ethanehydroxylate. Examples of plaque inhibitors include: cydiphosphonates and zeolites; desensitizing agents such as aluminum lactate, strontium chloride, and potassium nitrate; coating agents such as hydroxyethylcellulose dimethyldiallylammonium chloride; vitamins such as sodium chloride, alum, vitamin C (e.g., ascorbic acid), vitamin E (e.g., tocopherol acetate (tocopherol acetate), tocopherol nicotinate, tocopherol), pyridoxine, lysozyme chloride, glycyrrhetinic acid and its salts; water-soluble copper compounds such as copper chlorophyll and copper gluconate; amino acids such as alanine, glycine, and proline; plant extracts such as thyme, scutellaria baicalensis, clove, and witch hazel; and plaque inhibitors such as caropeptide and polyvinylpyrrolidone. The amount of active ingredients can be used within a range that does not hinder the effects of the present invention (a range that is pharmaceutically acceptable).

[0053] Examples of solvents include lower monohydric alcohols (preferably lower monohydric alcohols other than ethyl alcohol) and purified water. If the liquid oral composition of the present invention contains a lower monohydric alcohol, the amount may be such that the composition of the present invention is substantially free of ethyl alcohol, preferably 10% by mass or less, preferably 5% by mass or less, more preferably substantially free, and even more preferably no free.

[0054] Examples of oily components include hydrocarbons such as squalane, (light) liquid paraffin, petrolatum, and microcrystalline wax; higher alcohols (e.g., alcohols with 8 to 22 carbon atoms such as lauryl alcohol, cetyl alcohol, cetostearyl alcohol, oleyl alcohol, and isostearyl alcohol); higher fatty acids (e.g., fatty acids with 8 to 22 carbon atoms such as lauric acid, myristic acid, oleic acid, and isostearic acid); vegetable oils such as olive oil, castor oil, and coconut oil; and fatty acid esters such as isopropyl myristate.

[0055] [2. Dosage Form and Use] The liquid oral composition of the present invention can be applied to liquid products such as liquid toothpaste for regular brushing, liquid toothpaste for interdental use applied with interdental brushes or dental floss, topical agents applied to the gums and gingiva by taking them on a finger or sheet made of nonwoven fabric, topical products that are directly administered to areas such as interdental spaces and periodontal pockets using a container with a fine nozzle, and concentrated mouthwashes and gargles that are diluted with water or other liquids before use.

[0056] There are no particular limitations on the container used to contain the liquid oral composition of the present invention, and it can be filled into containers commonly used for liquid oral compositions. Specifically, such containers can be laminated containers consisting of a polyethylene layer, an ethylene methacrylic acid copolymer layer, a polyethylene terephthalate layer, an aluminum layer, a glass vapor-deposited layer, a polyvinyl alcohol layer, an ethylene vinyl alcohol copolymer layer, an acrylonitrile copolymer layer, paper, a recycled plastic layer, etc., or polyethylene containers, polyethylene terephthalate containers, polypropylene containers, etc. Various containers commonly used for liquid oral compositions can be used, such as tubular containers, mechanical or differential pressure dispenser containers, and film packaging containers such as pillow packaging. [Examples]

[0057] The present invention will be described below with reference to examples. The following examples are not intended to limit the present invention.

[0058] Mouthwashes with the compositions shown in Tables 1-5 were prepared by conventional methods and evaluated using the following methods. The results are shown in Tables 1-5.

[0059] [Raw materials used] Details of the raw materials used are as follows. -(A) component- Dipotassium glycyrrhizinate: Manufactured by Maruzen Pharmaceutical Co., Ltd. Monoammonium glycyrrhizinate: Manufactured by Maruzen Pharmaceutical Co., Ltd.

[0060] -(B) Component- Sodium lauroyl methyl taurate: Manufactured by Nikko Chemicals Co., Ltd., product name "NIKKOL® LMT" Sodium lauroyl methylalanine: Manufactured by NOF Corporation, product name "Softilt® AS-L" Sodium lauroyl glutamate: Manufactured by Asahi Kasei Chemicals Corporation, product name "AminoSurfact® ALMS-P1" Sodium myristoyl glutamate: Manufactured by Asahi Kasei Chemicals Corporation, product name "AminoSurfact® AMMS-P1" Sodium lauroyl sarcosinate: Manufactured by Nikko Chemicals Co., Ltd., product name "NIKKOL® Sarcosinate LN"

[0061] -(C) component- Fragrance compositions A-S: (The composition of each fragrance composition is shown in Tables 13 and 14.)

[0062] -Other ingredients- Sorbitol solution (70%): Manufactured by Mitsubishi Corporation Life Sciences Co., Ltd. Glycerin (85%): Manufactured by Lion Chemical Co., Ltd. Propylene glycol: Manufactured by ADEKA Corporation POE Hydrogenated Castor Oil (60): Manufactured by Japan Surfactant Industry Co., Ltd. Citric acid: Manufactured by Komatsuya Co., Ltd. Sodium citrate: Manufactured by Komatsuya Co., Ltd. purified water

[0063] [Method for evaluating flavor expression] The product was evaluated in a sensory test conducted by 10 expert panelists. Each participant took 10 mL of the mouthwash into their mouth, rinsed for 20 seconds, and evaluated whether the fragrance from the product was immediately noticeable in the nose, according to the scoring criteria below. The average of the 10 participants' scores was calculated, and the flavor expression was evaluated using the following criteria.

[0064] -Scoring Criteria- 4 points: I strongly noticed the fragrance derived from the perfume. 3 points: I could slightly detect the fragrance derived from the perfume. 2 points: I didn't really notice the fragrance derived from the perfume. 1 point: I didn't detect any fragrance from the perfume.

[0065] -Evaluation Criteria for Flavor Expression- ◎: Average score 3.5 points or more ○: Average score of 3.0 or higher but less than 3.5 points △: Average score between 2.0 and 3.0 ×: Average score less than 2.0 points

[0066] [Methods for evaluating oral stimulation] The product was evaluated in a sensory test conducted by 10 expert panelists. Each participant took 10 mL of mouthwash into their mouth, rinsed for 20 seconds, and evaluated whether they felt any irritation on the tip of their tongue according to the scoring criteria below. The average of the 10 participants' scores was calculated, and the flavor expression was evaluated according to the evaluation criteria below.

[0067] -Scoring Criteria- 4 points: No oral irritation was felt. 3 points: I didn't feel much irritation in my mouth. 2 points: I felt some irritation in my mouth. 1 point: I felt a lot of irritation in my mouth.

[0068] -Evaluation Criteria for Oral Stimulation- ◎: Average score 3.5 points or more ○: Average score of 3.0 or higher but less than 3.5 points △: Average score between 2.0 and 3.0 ×: Average score less than 2.0 points

[0069] [Table 1]

[0070] [Table 2]

[0071] [Table 3]

[0072] [Table 4]

[0073] [Table 5]

[0074] While the comparative mouthwash received low ratings for either flavor expression or oral irritation, the mouthwashes of Examples 1 to 23, which contained components (A) to (C) and whose ratio of component (A) content to component (B) content met the predetermined numerical range, received high ratings for both flavor expression and oral irritation, and also received high ratings for both flavor expression and suppression of oral irritation.

[0075] (Example prescription) Examples of formulations of liquid oral compositions to which the present invention is applied are shown below. In the following prescription examples 1 to 44, both flavor expression and oral irritation were highly rated, and both flavor expression and suppression of oral irritation received high marks.

[0076] [Table 6]

[0077] [Table 7]

[0078] [Table 8]

[0079] [Table 9]

[0080] [Table 10]

[0081] [Table 11]

[0082] [Table 12]

[0083] Furthermore, when samples prepared in the same manner as above were used, except that fragrance compositions B to S were used instead of fragrance composition A, the same results as in Examples 1 to 23, Comparative Examples 1 to 6, and Formulation Examples 1 to 44 were obtained when the flavor expression and oral irritation evaluations described above were performed. The liquid oral compositions of the present invention can exhibit good flavor expression and an inhibitory effect on oral irritation regardless of which fragrance composition is used. In addition, it was shown that when a fragrance composition containing at least one of the following, such as fragrance compositions A to S, is used, flavor expression is more favorably exhibited, even when glycyrrhizic acid or a salt thereof is used in combination.

[0084] [Table 13]

[0085] Table 14

[0086] Table 15

[0087] Table 16

[0088] Table 17

Claims

1. (A) Components: At least one selected from the group consisting of glycyrrhizic acid and its salts, (B) Component: At least one selected from the group consisting of acyl amino acids and their salts, (C) Ingredient: Fragrance It contains, The ratio of the content of component (A) to the content of component (B) is, (B) If component contains acyl sarcosine and its salts, the value is between 0.625 and less than 2.

2. (B) If component does not contain acyl sarcosine and its salts, the value is between 0.03 and less than 5. Substantially free of ethyl alcohol, Liquid oral composition.

2. The composition according to claim 1, wherein component (B) is at least one selected from the group consisting of acylmethyltaurine, acylmethylalanine, acylglutamic acid, acylsarcosine, and salts thereof.

3. (A) The liquid oral composition according to claim 1 or 2, wherein component (A) is at least one of dipotassium glycyrrhizinate and monoammonium glycyrrhizinate.

4. The composition according to claim 1 or 2, wherein the content of component (A) is 0.005 to 1.5% by mass.

5. The composition according to claim 1 or 2, wherein the content of component (B) is 0.01 to 1% by mass.

6. The composition according to claim 1 or 2, wherein component (C) is at least one selected from the group consisting of menthol, carvone, 1,8-cineole, anethole, cinnamic aldehyde, eugenol, methyl salicylate, thymol, and limonene.

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