Dry powder inhaler stick containing cough suppressant and dry powder inhaler containing the same

Abstract

The present invention provides a stick for a dry powder inhaler comprising a filter portion, a capsule portion, and a tube portion, wherein the capsule portion contains nicotine dry powder, and one or more of the filter portion and the tube portion contain a cough suppressant, and a dry powder inhaler comprising the same.

Description

Technical Field

[0001] The present invention relates to a stick for a dry powder inhaler containing a cough suppressant and a dry powder inhaler including the same.

Background Art

[0002] Nicotine is transmitted into the body in various ways, such as by inhaling combustion-type tobacco such as cigarettes, cigars, and pipe tobacco, by using a method in which an aerosol is generated by heating an aerosol product substance in a cigarette, or by directly inhaling nicotine powder or the like.

[0003] Among them, the method of directly inhaling nicotine powder is to directly deliver it to the user's airway by inhaling dry powder using a dry powder inhaler (DPI). The dry powder contains various active ingredients (drugs) in addition to nicotine for the purpose of improving diseases and the like.

[0004] DPI tobacco is an inhalation tobacco product that utilizes medical inhalation technology to inhale powder containing nicotine (1% or less by weight) so that smokers can obtain a sense of satisfaction. The inhalation tobacco product may include a powder (nicotine and a powder material for nicotine transfer), a stick containing a capsule containing the powder, and a device for realizing a smoking ritual.

[0005] On the other hand, when inhaling DPI tobacco, coughing occurs while the powder migrates to the respiratory tract, which is a factor that inhibits the satisfaction of consumers' inhalation.

[0006] In order to suppress or reduce the cough, menthol or the like is used. However, when the process of manufacturing and drying nicotine powder using menthol is carried out, problems such as a decrease in the yield of nicotine and the like, the uniformity of the powder size, and the storage stability may occur.

Summary of the Invention

Problems to be Solved by the Invention

[0007] One objective of the present invention is to solve the above-mentioned problems by applying the menthol application method, which is used as a cough suppressant when manufacturing existing DPI powders, to the filter components that make up the DPI sticks, rather than to the powder manufacturing process, thereby reducing cough suppression and decreasing quality degradation and process problems that occur in the manufacturing process of nicotine-containing powders.

[0008] However, the problems that this invention aims to solve are not limited to those mentioned above, and other problems not mentioned can be clearly understood by those with ordinary skill in the art from the following description. [Means for solving the problem]

[0009] According to one embodiment of the present invention, a stick for a dry powder inhaler includes a filter part, a capsule part, and a tube part, The capsule portion contains dried nicotine powder. The present invention provides a stick for a dry powder inhaler, characterized in that one or more of the filter portion and the tube portion contain a cough suppressant.

[0010] According to another embodiment of the present invention, a dry powder inhaler is provided, which includes the dry powder inhaler stick. [Effects of the Invention]

[0011] A stick for a dry powder inhaler containing a cough suppressant according to one aspect of the present invention, and a dry powder inhaler containing the same, have the advantages of efficient cough suppression and reduction of quality degradation and process problems that occur in the manufacturing process of nicotine-containing powder. [Modes for carrying out the invention]

[0012] The embodiments will be described in detail below with reference to the attached drawings. However, various modifications may be made to the embodiments, and the scope of the patent application will not be limited or restricted by such embodiments. All modifications, equivalents, or substitutes to the embodiments should be understood to be included within the scope of the patent.

[0013] The terms used in the embodiments are for illustrative purposes only and should not be construed as intended to limit them. Singular expressions include plural expressions unless the context clearly indicates otherwise. In this specification, terms such as “includes” or “having” indicate the presence of features, figures, steps, actions, components, parts, or combinations thereof described in the specification, and should not be understood as preemptively excluding the possibility of the presence or addition of one or more other features, figures, steps, actions, components, parts, or combinations thereof.

[0014] Unless otherwise defined, all terms used herein, including technical or scientific terms, have the same meaning as those generally understood by a person of ordinary skill in the art to which this embodiment belongs. Commonly used, predefined terms should be interpreted as having the meaning consistent with their meaning in the context of the relevant art, and not as ideal or overly formal unless expressly defined herein.

[0015] Furthermore, when explaining with reference to the attached drawings, the same components will be assigned the same reference numerals regardless of the reference numerals used in the drawings, and redundant explanations will be omitted. In the description of embodiments, if a specific explanation of related prior art is deemed to unnecessarily obscure the gist of the embodiment, such detailed explanation will be omitted.

[0016] Furthermore, in describing the components of the embodiments, terms such as first, second, A, B, (a), (b), etc., may be used. These terms are used to distinguish a component from other components, and the terms do not limit the essence, order, or sequence of the component in question.

[0017] Components that have functions common to components included in any of the embodiments will be described using the same name in the other embodiments. Unless otherwise stated, the descriptions in one embodiment will also apply to the other embodiments, and specific descriptions will be omitted to the extent that they overlap.

[0018] As used herein, the term "Dry Powder Inhaler (DPI)" refers to a device that delivers substances, such as those produced by the reaction of nicotine-related substances and organic acid substances, into the user's lungs via the user's oral cavity.

[0019] According to one embodiment of the present invention, a stick for a dry powder inhaler includes a filter part, a capsule part, and a tube part, The capsule portion contains dried nicotine powder. The present invention provides a stick for a dry powder inhaler, characterized in that one or more of the filter portion and the tube portion contain a cough suppressant.

[0020] The components of the aforementioned dry powder inhaler stick are described in detail below.

[0021] [Capsule section]

[0022] The capsule portion contained in the stick for a dry powder inhaler contains nicotine dry powder and does not contain a cough suppressant separately, and the nicotine dry powder is a substance containing nicotine or a nicotine salt.

[0023] Here, the nicotine salt exists in the form of a salt of nicotine and an organic acid. The organic acid corresponds to, but is not limited to, lactic acid, tartaric acid, pyruvic acid, and / or salicylic acid.

[0024] When forming an organic acid and nicotine salt as described above, for example, it may have the form of nicotine lactate, nicotine tartrate, nicotine pyruvate or nicotine salycilate. Among them, considering stability and harmfulness to the human body together in terms of the use of the nicotine dry powder for human inhalation, the organic acid is preferably lactic acid. Therefore, the nicotine salt is preferably nicotine lactate.

[0025] The nicotine dry powder may contain an amino acid and an excipient in addition to the nicotine or nicotine salt.

[0026] The type of amino acid is not greatly restricted, but corresponds to one or more of leucine, lysine, valine, arginine, threonine, and / or methionine. Preferably, the amino acid may contain leucine.

[0027] Thus, when leucine is included as an amino acid, unlike the case of other amino acids, the fluidity and transfer amount of the finally formed nicotine dry powder can be improved.

[0028] Also, the content of the amino acid contained at this time is preferably 5% by weight or less based on the entire dry powder. By adjusting the content of the amino acid to 5% by weight or less as described above, the particle size and particle size distribution of the finally formed nicotine dry powder can be improved.

[0029] The excipients contained in the dried nicotine powder may include sugars and / or sugar alcohols, and the sugars may include sucrose, trehalose, dextrose, glucose, maltose, etc. Furthermore, the sugar alcohols may include mannitol, sorbitol, galactitol, maltitol, xylitol, lactitol, etc.

[0030] Of these, the excipient preferably includes mannitol, which has a shape close to spherical in order to ensure the safety of the additive and the flowability of the powder.

[0031] The nicotine-dried powder is specifically manufactured using nicotine or nicotine salts, amino acids, and excipients, as detailed above, through a spray-drying process. When nicotine-dried powder is manufactured using a spray-drying process, better results are obtained in terms of yield compared to when jet milling is used. This is understood to be because, when using jet milling, development occurs in which nicotine volatilizes into the air due to the properties of nicotine-dried powder.

[0032] On the other hand, when spray drying is performed, the solvent, nicotine or nicotine salt, amino acids, and excipients can be first stirred via a magnetic stirrer before spray drying is carried out. In this case, water is used as the solvent, and the mixture is spray dried at an inlet temperature of approximately 100°C with a specific spray flow rate and ambient flow rate to form nicotine-dried powder.

[0033] The spray flow rate is considered appropriate at 2-7 mL / min, as it is a factor that determines the final yield, total spray time, and properties of the nicotine dry powder. The atmospheric flow rate is considered appropriate at 0.3-0.4 m / min, taking into account the final yield and particle size of the nicotine dry powder. 3 / min appears to be appropriate. Furthermore, the aspirator flow rate is determined by pressure or flow rate depending on the equipment characteristics, and around 250 kPa or 1200 L / hr appears to be appropriate.

[0034] Thus, unlike existing DPI cigarettes, the capsule portion according to one embodiment of the present invention does not contain a separate cough suppressant such as menthol during the production of the nicotine dried powder (spray drying process). Therefore, it is not necessary to maintain a temperature of 80°C or higher during the manufacturing process, and when a cough suppressant such as menthol is added to the nicotine dried powder, manufacturing process problems such as reduced yield, uneven powder size, and storage stability do not occur.

[0035] [Functional part]

[0036] The filter portion contained in the stick for dry powder inhaler may consist of a cellulose acetate filter containing acetate tow, a paper filter, or a filter made of a polymer material. The filter portion consists of one segment, or it may be divided into multiple segments such as a first filter portion, a second filter portion, etc.

[0037] The filter portion may contain a cough suppressant according to one embodiment of the present invention. Examples of cough suppressants include menthol, mint, saccharin, and benzocaine, and preferably contains menthol.

[0038] For example, when menthol is used as a cough suppressant and a cellulose acetate filter containing acetate tow is formed, the menthol may be supported in a capsule and positioned inside the acetate tow, or the acetate tow may be treated with a TJNS (Transport Jet Nozzle System) fragrance.

[0039] On the other hand, if the filter section is divided into multiple segments, a filter containing a fragranced filter or a capsule carrying a cough suppressant may be included in at least one of the multiple segments.

[0040] [Tube section]

[0041] The tube portion included in the dry powder inhaler stick refers to a part molded by applying steam pressure or the like, in the form of an acetate tow tube. By applying acetate tow material, it holds flavoring substances, and when the consumer smokes, the held flavoring substances move into the mouth, allowing them to perceive the characteristic aroma and taste. Furthermore, as explained in the filter portion above, it may also have a form that contains a cough suppressant.

[0042] In this case, the type of cough suppressant is substantially the same as the cough suppressant in the filter section described in detail above, and the cough suppressant, such as menthol, may be sprayed into or out of the tube section.

[0043] Cough suppressants such as menthol may be selectively included in the filter portion or the tube portion, or they may be located in both the filter portion and the tube portion.

[0044] Thus, by positioning the cough suppressant in the filter and / or tube section separately from the nicotine dry powder located in the capsule section, it is not necessary to manufacture a powder containing a cough suppressant such as menthol simultaneously with the nicotine dry powder. Compared to manufacturing the final powder by mixing nicotine dry powder and a cough suppressant such as menthol, the menthol content applied to the acetate toe can be adjusted relatively accurately and easily, resulting in advantages such as yield, uniformity of powder size, and storage stability.

[0045] On the other hand, according to another embodiment of the present invention, a dry powder inhaler including the dry powder inhaler stick can be provided.

[0046] In this case, the stick for the dry powder inhaler included in the dry powder inhaler can be considered to be substantially the same as the one described in detail above.

[0047] The configuration of the present invention and its effects will be described in detail below through embodiments and comparative examples. However, these embodiments are intended to illustrate the present invention more specifically, and the scope of the present invention is not limited to these embodiments.

[0048] <Embodiment>

[0049] 1. Manufacturing Example 1

[0050] (1) Manufacturing of dried nicotine powder - spray drying

[0051] After weighing the materials according to the composition ratios shown in Table 1 below, they were placed in DI water and stirred for about 10 minutes, and then dried nicotine powder was produced through a spray drying process. [Table 1]

[0052] (2) Manufacturing of capsules containing nicotine dry powder

[0053] The 30 mg of nicotine powder produced was weighed and manually placed into inhalation capsules to manufacture the capsules.

[0054] 2. Manufacturing Example 2

[0055] A DPI stick, comprising a filter section, capsule section, and tube section made of acetate toe, was manufactured by applying menthol, a cough suppressant, to the DPI stick, as shown in Table 2 below.

[0056] When menthol was applied to the filter section, it was sprayed using the TJNS method, or when menthol-containing capsules were applied to the tube section, the menthol was sprayed into the inside of the tube to manufacture the molded tube. [Table 2]

[0057] 3. Test example: Measurement of particle size, particle size distribution, and migration characteristics

[0058] The data shows a comparison of the aerodynamic mass-average particle size (MMAD), fine particle fraction (FPF), and transfer amount when nicotine dry powder is produced alone, and when nicotine dry powder and flavor powder are mixed together. [Table 3]

[0059] As shown in Table 3 above, it was confirmed that when only nicotine dried powder is produced, the MMAD value is lower, the FPF value is closer to 50%, and the transfer amount is also superior compared to when nicotine dried powder and flavor powder are mixed to produce the powder.

[0060] This study revealed that when only nicotine dry powder is applied to the capsule separately, the efficiency of nicotine inhalation by the user is superior compared to when both the nicotine dry powder and the fragrance powder are applied to the capsule. It also showed that it is more preferable for menthol, a cough suppressant, to be applied to the filter or tube rather than to the capsule.

[0061] Although embodiments of the present invention have been described in detail above with reference to the drawings, a person with ordinary skill in the art can apply various technical modifications and variations based on the above. For example, the described techniques may be performed in a different order than described, and / or the components of the described systems, structures, devices, circuits, etc. may be combined or assembled in a different manner than described, and substituted or replaced by other components or equivalents, while still achieving the desired results.

[0062] Therefore, other embodiments, other examples, and those equivalent to the claims described below also fall within the scope of the claims.

Claims

1. A stick for a dry powder inhaler, comprising a filter section, a capsule section, and a tube section, The capsule portion contains dried nicotine powder, A stick for a dry powder inhaler, characterized in that one or more of the filter portion and the tube portion contain a cough suppressant.

2. The dry powder inhaler stick according to claim 1, wherein the cough suppressant comprises one or more of menthol, mint, saccharin, and benzocaine.

3. The filter section includes acetate tow, The dry powder inhaler stick according to claim 1, wherein the cough suppressant is the acetate tow that has been flavored with TJNS (Transport Jet Nozzle System).

4. The filter portion comprises a capsule containing a cough suppressant and an acetate toe, as described in claim 1, for a dry powder inhaler stick.

5. The dry powder inhaler stick according to claim 1, wherein the cough suppressant is sprayed inside or outside the tube portion.

6. The dry nicotine powder in the capsule portion comprises nicotine or a nicotine salt, an amino acid, and an excipient, as described in claim 1, for use with a dry powder inhaler stick.

7. The nicotine dry powder contains nicotine salts, The aforementioned nicotine salt contains nicotine, A stick for a dry powder inhaler according to claim 6, comprising a salt containing one or more selected from the group consisting of lactic acid, tartaric acid, pyruvic acid, and salicylic acid.

8. The nicotine salt comprises nicotine and lactic acid, as described in claim 6, for a dry powder inhaler stick.

9. The stick for a dry powder inhaler according to claim 6, wherein the amino acid comprises one or more selected from the group consisting of leucine, lysine, valine, arginine, threonine, and methionine.

10. The aforementioned amino acid includes leucine, The dry powder inhaler stick according to claim 6, wherein the leucine content is 5% by weight or less based on the total weight of the nicotine dry powder.

11. The excipient comprises one or more of sugars and sugar alcohols. The aforementioned sugar comprises one or more selected from the group consisting of lactose, sucrose, trehalose, dextrose, glucose, and maltose. The dry powder inhaler stick according to claim 6, wherein the sugar alcohol comprises one or more selected from the group consisting of mannitol, sorbitol, galactitol, maltitol, xylitol, and lactitol.

12. The dry powder inhaler stick according to claim 6, wherein the excipient comprises mannitol.

13. A dry powder inhaler comprising a stick for a dry powder inhaler as described in claim 1.

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