Composition for improving scalp health and method for improving scalp health using the same

Abstract

The present invention provides a composition for improving scalp health, comprising a 1,2-alkanediol having 6 to 16 carbon atoms per molecule and hydrolyzed yeast protein. The present invention further provides a method for improving scalp health, comprising applying such composition to the scalp and / or hair.

Description

Technical Field

[0001] Technical Field The present invention relates to a composition for improving scalp health and a method for improving scalp health. In particular, the present invention relates to a composition for improving scalp health, comprising a 1,2-alkanediol having 6 to 16 carbon atoms per molecule and a hydrolyzed yeast protein, and a method for improving scalp health, comprising applying such a composition to the scalp and / or hair.

Background Art

[0002] Background of the Invention Sensitive scalp, which means that the scalp is very itchy, has been frequently seen in recent years. Itching of the scalp is one of the most serious discomforts and can lead to a serious impairment of the quality of life. According to world statistics, the morbidity rate of scalp itching is estimated to be in the range of 13% to 45%. Therefore, the demand in the market for treating scalp itching is increasing.

[0003] Currently, antifungal drugs, antihistamines and moisturizers are the most widely used solutions for treating scalp itching. However, antifungal drugs and antihistamines only treat the symptoms of scalp itching, and antifungal drugs may even damage the scalp microbiota, and the effect of moisturizers is limited.

Summary of the Invention

Problems to be Solved by the Invention

[0004] An object of the present invention is to provide a composition for improving scalp health and a method for improving scalp health that can effectively treat scalp itching.

Means for Solving the Problems

[0005] Summary of the Invention In a first embodiment, the present invention provides a composition for improving scalp health, comprising a 1,2-alkanediol having 6 to 16 carbon atoms per molecule and hydrolyzed yeast protein.

[0006] In a second embodiment, the present invention provides a method for improving scalp health, comprising applying a composition according to the present invention to the scalp and / or hair.

[0007] The compositions and methods of the present invention are all based on the following remarkable discovery by the inventors: Compositions comprising a combination of a 1,2-alkanediol having 6 to 16 carbon atoms per mole and hydrolyzed yeast protein can effectively treat itchy scalps; in particular, they effectively reduce the severity of itching, increase the number of subjects who recover from itchiness to an itchy state, reduce the number of itchy scalp species, and eliminate Clostridium sensuality stricte 1, Leptormia, and Acinetobacter (which are abundant on itchy scalps) on the itchy scalp. - Reduces the relative amounts of Enterobacter, Azoarcus, Bacteroides, Comamonas, Panonibacter, Novosphingobium, Klebsiella, Escherichia coli, Shigella, Corynebacterium and / or Sporolactobacterium, increases the relative amounts of Cutibacterium (which are abundant on itchy scalps), Staphylococcus and Lawsonella, reduces pathways related to the synthesis of butyrosine and neomycin on itchy scalps, and / or increases pathways related to amino acid and biotin metabolic pathways on itchy scalps. [Brief explanation of the drawing]

[0008] [Figure 1] Figure 1 shows the changes in Faith_pd and observed ASVs in groups 1 and 3, which reflect a decrease in the abundance of itchy scalp species. [Figure 2] Figure 2 shows the modification of route Ko00524 by groups 1 and 3. [Modes for carrying out the invention]

[0009] Detailed description of the invention As those skilled in the art will understand, this description is merely an illustrative description of exemplary embodiments and is not intended to limit broader aspects of the invention. Each of the embodiments described herein can be combined with any other embodiment unless expressly indicated otherwise. In particular, any feature indicated as preferred or advantageous can be combined with any other feature indicated as preferred or advantageous.

[0010] Unless otherwise specified, the terms “a,” “an,” and “the” as used herein include both singular and plural referents.

[0011] As used herein, the terms “comprising” and “comprises” are synonymous with “including,” “includes,” “containing,” or “contains,” and are comprehensive or open-ended, not precluding further, unlisted components, elements, or process steps.

[0012] Unless otherwise specified, a list of numerical endpoints includes all numbers and fractions contained within their respective ranges, as well as the listed endpoints.

[0013] Unless otherwise defined, all terms used in the disclosure of this invention, including technical and scientific terms, have the meanings generally understood by those skilled in the art to which this invention belongs.

[0014] Surprisingly, according to the present invention, the inventors have found that a composition according to the present invention, comprising a combination of a 1,2-alkanediol having 6 to 16 carbon atoms per molecule and hydrolyzed yeast protein, can effectively treat scalp itchiness, particularly by influencing the scalp microbiome and relative metabolic pathways.

[0015] In a first embodiment, the disclosure relates to compositions for improving scalp health, generally comprising 1,2-alkanediols having 6 to 16 carbon atoms per molecule and hydrolyzed yeast proteins.

[0016] 1,2-alkanediols having 6 to 16 carbon atoms per molecule According to the present invention, the composition contains a 1,2-alkanediol having 6 to 16 carbon atoms per molecule. Preferably, the 1,2-alkanediol having 6 to 16 carbon atoms per molecule is selected from the group consisting of 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, 1,2-tetradecanediol, 1,2-hexadecanediol, and mixtures thereof. More preferably, the 1,2-alkanediol having 6 to 16 carbon atoms per molecule is selected from the group consisting of 1,2-hexanediol, 1,2-octanediol, 1,2-decanediol, 1,2-dodecanediol, and mixtures thereof. More preferably, the 1,2-alkanediol having 6 to 16 carbon atoms per molecule is selected from the group consisting of 1,2-octanediol, 1,2-decanediol, 1,2-dodecanediol, and mixtures thereof. Most preferably, the 1,2-alkanediol having 6 to 16 carbon atoms per molecule is 1,2-decanediol.

[0017] In preferred embodiments of the present invention, the 1,2-alkanediol having 6 to 16 carbon atoms per molecule is used in a form selected from the group consisting of the following forms: 1,2-decanediol available from SymRise under the trade name SymClariol; a mixture of 1,2-hexanediol and 1,2-octanediol available from SymRise under the trade name SymDiol 68; a mixture of 1,2-hexanediol, 1,2-octanediol and troporone available from SymRise under the trade name SymDiol 68T; a mixture of 1,2-octanediol, 1,2-hexanediol and methylbenzyl alcohol available from SymRise under the trade name SymTriol; a mixture of phenoxyethanol, 1,2-decanediol and 1,2-hexanediol available from SymRise under the trade name SymOcide PS; and mixtures thereof. In a more preferred embodiment of the present invention, the 1,2-alkanediol having 6 to 16 carbon atoms per molecule is used in a form selected from the group consisting of the following forms: 1,2-decanediol available from Symrise under the trade name SymClariol, phenoxyethanol available from Symrise under the trade name SymOcide PS, a mixture of 1,2-decanediol and 1,2-hexanediol, and a mixture thereof. In a more preferred embodiment of the present invention, the 1,2-alkanediol having 6 to 16 carbon atoms per molecule is used in the form of 1,2-decanediol available from Symrise under the trade name SymClariol.

[0018] Preferably, the content of 1,2-alkanediol having 6 to 16 carbon atoms per molecule is from 0.01% by weight to 10.0% by weight, preferably from 0.02% by weight to 5.0% by weight, more preferably from 0.025% by weight to 2.0% by weight, based on the total weight of the composition. When the content of 1,2-alkanediol having 6 to 16 carbon atoms per molecule is higher than 10.0% by weight with respect to the total weight of the composition, the composition is not stable for a long period. When the content of 1,2-alkanediol having 6 to 16 carbon atoms per molecule is less than 0.01% by weight with respect to the total weight of the composition, the advantageous technical effects of the present invention are not achieved.

[0019] In the most preferred embodiment of the present invention, the 1,2-alkanediol having 6 to 16 carbon atoms per molecule is used in the form of 1,2-decanediol under the trade name of SymClariol, and the content of SymClariol is from 0.1% by weight to 2.0% by weight, preferably from 0.3% by weight to 1.5% by weight, more preferably from 0.4% by weight to 1.3% by weight, based on the total weight of the composition.

[0020] Hydrolyzed yeast protein According to the present invention, the composition contains hydrolyzed yeast protein. As used herein, the term "hydrolyzed yeast protein" refers to any hydrolyzed yeast protein conventionally used in hair and / or scalp care products, preferably a substance having CAS No. 100684-36-4.

[0021] Preferably, in the present invention, the hydrolyzed yeast protein is used in the form of a mixture containing hydrolyzed yeast protein, 1,2-pentanediol and 1,3-butanediol. Preferably, the mixture is available from BASF under the trade name of Relipidium, particularly Relipidium A00265 and / or Relipidium BC10096. More preferably, the mixture is available under the trade name of Relipidium BC10096.

[0022] In a preferred embodiment of the present invention, the content of the hydrolyzed yeast protein is from 0.01% to 10.0% by weight, preferably from 0.02% to 5.0% by weight, more preferably from 0.03% to 1.0% by weight, based on the total weight of the composition. When the content of the hydrolyzed yeast protein is higher than 10.0% by weight relative to the total weight of the composition, the resulting composition has a problem of incompatibility. When the content of the hydrolyzed yeast protein is less than 0.01% by weight based on the total weight of the composition, the advantageous technical effects of the present invention cannot be achieved.

[0023] In the most preferred embodiment of the present invention, the hydrolyzed yeast protein is used in the form of Relipidium, and the content of Relipidium is from 0.1% to 1.0% by weight, preferably from 0.3% to 0.7% by weight, more preferably from 0.4% to 0.6% by weight, based on the total weight of the composition.

[0024] In a preferred embodiment of the present invention, the composition contains 1,2 - decanediol under the trade name SymClariol from Simrise and the hydrolyzed yeast protein used in the form of Relipidium; the content of SymClariol is from 0.1% to 2.0% by weight, preferably from 0.3% to 1.5% by weight, more preferably from 0.4% to 1.3% by weight, based on the total weight of the composition, and / or the content of Relipidium is from 0.1% to 1.0% by weight, preferably from 0.3% to 0.7% by weight, more preferably from 0.4% to 0.6% by weight, based on the total weight of the composition.

[0025] additives The composition according to the present invention may further contain additives conventionally used in hair and / or scalp care products, including, but not limited to, water, surfactants, hair moisturizers, thickeners, preservatives, fragrances, pH adjusters, and / or skin moisturizers.

[0026] The presence, type, and amount of additives can be determined by those skilled in the art according to their actual needs, as long as they do not adversely affect the purpose of the present invention. For example, if the composition is a shampoo, it may further contain surfactants, hair humectants, thickeners, preservatives, and / or fragrances, and if the composition is a scalp care product such as a scalp serum, it may further contain thickeners, pH adjusters, skin humectants, preservatives, and / or fragrances.

[0027] The composition according to the present invention may be a hair care, styling and / or color product, and / or scalp care product, such as a shampoo, hair conditioner, hair styling product, hair color product, scalp serum, and / or scalp spray. Preferably, the composition according to the present invention is a shampoo or scalp serum.

[0028] The compositions according to the present invention can be prepared according to conventional methods in the art, such as by mixing all the components of the composition at room temperature. Furthermore, the compositions of the present invention can be used according to conventional methods in the art.

[0029] The composition of the present invention can effectively treat scalp itchiness, and in particular can effectively reduce scalp itchiness, increase the number of subjects who recover from itchiness to non-itchiness, reduce the variety of scalp itchiness types, reduce the relative amounts of Clostridium sensuality stricte 1, Leptormbia, Acinetobacter, Enterobacter, Azoarcus, Bacteroides, Comamonas, Panonibacter, Novosphingovium, Klebsiella, Escherichia coli, Shigella, Corynebacterium and / or Sporolactobacterium in scalp itchiness, increase the relative amounts of Cucibacterium, Staphylococcus and Lawsonella in scalp itchiness (which are abundant in normal scalps), reduce pathways related to the synthesis of butyrosine and neomycin in scalp itchiness, and / or increase pathways related to amino acid metabolism and biotin metabolism in scalp itchiness.

[0030] In a second aspect, the disclosure relates to a method for improving scalp health, which generally involves applying a composition according to the present invention to the scalp and / or hair.

[0031] With regard to methods for improving scalp health, and further preferred embodiments of hair care, styling, and / or color products, the provisions relating to the compositions of the present invention shall apply mutatis mutandis.

[0032] The present invention will be described in more detail using the following examples, but this should not be understood as limiting the concept of the present invention. [Examples]

[0033] Examples 1. Preparation of compositions 1-6 The following raw materials are used in the examples. The water was obtained from Henkel. I obtained Hostapur OS solution from Clariant. I obtained Pureact WS-70 from Innospec Active Chemicals. Coco-glucoside 52% was obtained from BASF. Cocamidopropyl betaine 40% was obtained from BASF. The 99.5% glycerin was obtained from KLK Oleo. I obtained the Merquat 281 from Lubrizol. I obtained glucamete DOE-120 from Lubrizol. Nutrilan Keratin W PP was obtained from BASF. 80% DAB lactate was obtained from Purac Biochem. PEG-7 glyceryl cocoate was obtained from BASF. Castor oil aqueous solution, 40 EO, was obtained from Croda. Parfum 711495 Wonderland was obtained from Symrise. Sodium benzoate was obtained from DSM. SymClariol 344028 was obtained from Symprise. Relipidium BC10096 was obtained from BASF. Carbomer 50,000-60,000 mPas was obtained from OQWMA. Sodium hydroxide pearl was obtained from Merck. Regular citric acid monohydrate was obtained from Inter-Harz. D-Panthenol 75% was obtained from BASF. Propanediol-1,2 was obtained from Dow. I obtained the Sensiva SC 50 from Ashland. Caprylyl glycol was obtained from Symprise. SymDiol 68 was obtained from Symprise.

[0034] [Table 1]

[0035] [Table 2]

[0036] [Table 3]

[0037] [Table 4]

[0038] [Table 5]

[0039] [Table 6]

[0040] Compositions 1-4 (all comparative compositions) shown in Tables 1-4 and compositions 5-6 (all compositions for improving scalp health according to the present invention) shown in Tables 5-6 were prepared by dispersing a surfactant or carbomer in water at room temperature while stirring, adding other substances including a humectant, preservative and active substance (if any) one at a time while stirring, and then adding sodium hydroxide and / or fragrance to the mixture.

[0041] 2. Method and results for measuring the severity of itching The severity of itching was measured using a Visual Analogue Scale (VAS), a numerical score scale ranging from 1 to 10, which is a method for assessing itching. The VAS is a 10 cm long line, and subjects indicated the intensity of itching by crossing the line at points corresponding to the severity of their itching. Subjects were told that the beginning of the scale represents no pruritus (0 points), and the end represents the most severe pruritus they could imagine (10 points). For example, this measurement method is described in Reich A, Heisig M, Phan NQ, et al. Visual analogue scale: evaluation of the instrument for the assessment of pruritus [J]. Acta Derm Venereol, 2012, 92(5):497-501.

[0042] In this study, "itchy scalp" refers to the scalp of subjects with a VAS score of 6 or higher, while "normal scalp" refers to the scalp of subjects who, based on evaluation by a specialist dermatologist and subjective evaluation by the subjects, are free from scalp diseases such as dandruff and seborrheic dermatitis, have a VAS score of 2 or lower, and do not experience scalp itching.

[0043] 125 Chinese women with itchy scalps (VAS > 6) were screened by completing a 3S questionnaire, self-scoring the severity of their itching, and having their scalp condition and the degree of itching evaluated by a specialist dermatologist. They were randomly divided into three groups: Group 1, consisting of 40 subjects; Group 2, consisting of 43 subjects; and Group 3, consisting of 42 subjects. Group 1 used compositions 1 and 2, Group 2 used compositions 3 and 4, and Group 3 used compositions 5 and 6. All subjects used both the shampoo and scalp serum according to the following method.

[0044] (1) Shampoo I shampoo every other day, washing my hair twice each time. Specifically, I wet my hair, apply shampoo, rinse thoroughly, shampoo again, massage, and then rinse thoroughly again.

[0045] (2) Leave-on scalp serum As described above, after shampooing, dry the scalp and hair, take a soybean-peanut-sized amount of scalp serum, place it on your fingertips, and apply it to the center of the crown of your head with both hands, massaging the scalp until the serum is completely absorbed. Next, repeat the same process, applying the serum to both sides of the center of the crown of your head, the posterior nostril area, the center of the nasal septum, both sides of the nasal septum, and any itchy areas, and confirm that the serum is completely absorbed.

[0046] After 28 days, all subjects re-scored their VAS scores according to the method described above. The mean VAS scores for groups 1 and 3 on day 0 and day 28 are shown in Table 7.

[0047] [Table 7]

[0048] From the above, it can be seen that the composition of the present invention (Group 3, etc.) containing 1,2-alkanediols having 6 to 16 carbon atoms per molecule and hydrolyzed yeast protein, compared to compositions that do not contain 1,2-alkanediols having 6 to 16 carbon atoms per molecule and hydrolyzed yeast protein (Group 1, etc.), more effectively reduces the severity of itching.

[0049] 3. Measurement method and results for the number of subjects whose itching disappeared The number of subjects in groups 1-3 whose itching subsided to no itching (VAS score of 2 or less) was tallied, and the results are shown in Table 8.

[0050] [Table 8]

[0051] From the above, when comparing a composition that does not contain a 1,2-alkanediol having 6 to 16 carbon atoms per molecule and hydrolyzable yeast protein (e.g., Group 1) with a composition that contains a 1,2-alkanediol having 6 to 16 carbon atoms per molecule but does not contain hydrolyzable yeast protein (e.g., Group 2), it can be seen that after using the composition according to the present invention (e.g., Group 3) which contains a 1,2-alkanediol having 6 to 16 carbon atoms per molecule and hydrolyzable yeast protein, many subjects experienced a complete elimination of itching.

[0052] 4. Method and results for measuring the abundance of causes of scalp itchiness 125 Chinese female subjects with itchy scalps (VAS > 6) were also examined for microbiome issues. First, on day 0, microbial collection areas were marked on the scalps of all subjects.

[0053] To collect as many microorganisms as possible in the microbial collection area, each itchy area of ​​a 6cm × 0.5cm subject (hereinafter referred to as "itch sample") was swabbed with five sterile cotton swabs that had been dipped at least 10 times in sterile saline. A total of 125 itchy samples were collected. Bacterial DNA from all samples was extracted according to the slightly modified DNeasy Blood & Tissue Kit (Qiagen, #69506) guidelines, and all samples were subjected to high-throughput sequencing at Shanghai Personalbio Technology Co., Ltd. using the Illumina Novaseq sequencing platform and PE250 strategy. Next, all samples were used for droplet digital PCR quantification, and all microbial data obtained from the above were analyzed using USEARCH (version 11.0.667) and the QIIME2 platform (version 2021.04, https: / / qiime2.org).

[0054] On the 28th day after using the shampoo and serum as described above, the same process and analysis were performed.

[0055] To analyze the diversity of sequencing results from 125 samples, Faith_pd and observed ASVs were analyzed.

[0056] The Faith_pd index not only indicates richness but also shows the relationships between species on the evolutionary tree, with higher pd scores indicating species originating from different locations on the evolutionary tree. Observed ASVs only characterize species information without population information, intuitively representing the number of species within a group.

[0057] As shown in Figure 1, the results for Faith_pd and observed ASVs showed that, compared to compositions that did not contain either 1,2-alkanediols with 6 to 16 carbon atoms per molecule or hydrolyzable yeast protein (e.g., Group 1), compositions containing both 1,2-alkanediols with 6 to 16 carbon atoms per molecule and hydrolyzable yeast protein (e.g., Group 3) showed a more significant reduction in both Faith_pd and observed ASVs after 28 days of use as described above.

[0058] Furthermore, according to PCT / CN2022 / 104287 (Henkel's concurrently pending PCT international application, incorporated herein by reference), the microorganisms of an itchy scalp are thought to be more species-rich than those of a normal scalp.

[0059] The results above demonstrate that the composition of the present invention, comprising a 1,2-alkanediol having 6 to 16 carbon atoms per molecule and hydrolyzed yeast protein, can more significantly reduce the abundance of scalp itchiness-causing factors and treat scalp itchiness more effectively compared to a composition that does not contain a 1,2-alkanediol having 6 to 16 carbon atoms per molecule and hydrolyzed yeast protein.

[0060] 5. Method and results for measuring the relative abundance of bacteria on itchy scalps The relative abundance of bacterial species composition was also analyzed in 125 Chinese female subjects who experienced scalp itchiness (VAS > 6).

[0061] The results for the relative amount of bacterial compositions on itchy scalps show that, compared to compositions that do not contain either 1,2-alkanediols with 6 to 16 carbon atoms per molecule or hydrolyzed yeast protein (e.g., Group 1), and compositions that contain 1,2-alkanediols with 6 to 16 carbon atoms per molecule but do not contain hydrolyzed yeast protein (e.g., Group 2), the compositions of the present invention that contain both 1,2-alkanediols with 6 to 16 carbon atoms per molecule and hydrolyzed yeast protein (e.g., Group 3) are more effective on itchy scalps. The study showed a more significant reduction in the relative amounts of Clostridium sensuality stricte 1, Leptormbia, Acinetobacter, Enterobacter, Azoarcus, Bacteroides, Comamonas, Panonibacter, Novosphingovium, Klebsiella, Escherichia coli, Shigella, Corynebacterium and / or Sporolactobacterium on the above (abundantly present on itchy scalps), and a more significant increase in the relative amounts of Cucibacterium, Staphylococcus and Lawsonella on the above (abundantly present on normal scalps). Furthermore, Table 9 shows that, compared to compositions that do not contain either 1,2-alkanediols having 6 to 16 carbon atoms per molecule or hydrolyzed yeast protein (e.g., Group 1), and compositions that contain 1,2-alkanediols having 6 to 16 carbon atoms per molecule but do not contain hydrolyzed yeast protein (e.g., Group 2), using the composition of the present invention (e.g., Group 3) that contains both 1,2-alkanediols having 6 to 16 carbon atoms per molecule and hydrolyzed yeast protein resulted in a greater number of downregulated ASVs concentrated on itchy scalps and a smaller number of upregulated ASVs concentrated on itchy scalps.

[0062] Therefore, based on the invention of PCT / CN2022 / 104287, it can be concluded that a composition containing both a 1,2-alkanediol having 6 to 16 carbon atoms per molecule and hydrolyzed yeast protein according to the present invention can treat scalp itchiness more effectively than a composition containing a 1,2-alkanediol having 6 to 16 carbon atoms per molecule and hydrolyzed yeast protein, compared to a composition containing a 1,2-alkanediol having 6 to 16 carbon atoms per molecule and not containing hydrolyzed yeast protein.

[0063] [Table 9]

[0064] 6. Methods and results of measuring metabolic pathways To investigate the functional potential of the scalp microbial community, ASV abundance files and representative sequence files from the 125 samples obtained above were analyzed based on PICRUST2 analysis.

[0065] As shown in Figure 2, the metabolic pathway results showed that, compared to compositions that did not contain either 1,2-alkanediols having 6 to 16 carbon atoms per molecule or hydrolyzable yeast protein (e.g., Group 1), the biosynthesis of the butyrosine and / or neomycin pathway (Ko00524) was significantly downregulated in itchy scalps, and the metabolic pathways of amino acids, including alanine, aspartic acid, and glutamate metabolism, lysine biosynthesis, D-glutamine and D-glutamate metabolism, as well as biotin and thiamine metabolism, were significantly upregulated. Therefore, based on the invention of PCT / CN2022 / 104287, it can be concluded that a composition containing both a 1,2-alkanediol having 6 to 16 carbon atoms per molecule and hydrolyzed yeast protein according to the present invention can treat scalp itchiness more effectively than a composition containing neither a 1,2-alkanediol having 6 to 16 carbon atoms per molecule nor hydrolyzed yeast protein.

[0066] Based on the above, compared to compositions that do not contain either a 1,2-alkanediol having 6 to 16 carbon atoms per molecule or hydrolyzable yeast protein, and compositions that contain a 1,2-alkanediol having 6 to 16 carbon atoms per molecule but do not contain hydrolyzable yeast protein, the composition of the present invention, which contains a 1,2-alkanediol having 6 to 16 carbon atoms per molecule (such as SymClariol) and hydrolyzable yeast protein (such as Relipidium), can more effectively treat scalp itchiness and improve scalp health.

[0067] While several preferred embodiments have been described, many modifications and variations can be made in light of the above teachings. Therefore, it should be understood that the present invention can be implemented in ways other than those specifically described without departing from the scope of the appended claims.

Claims

1. A composition for improving scalp health, comprising a 1,2-alkanediol having 6 to 16 carbon atoms per molecule and hydrolyzed yeast protein.

2. The composition according to claim 1, wherein the 1,2-alkanediol having 6 to 16 carbon atoms per molecule is selected from the group consisting of 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, 1,2-tetradecanediol, 1,2-hexadecanediol and mixtures thereof, preferably selected from the group consisting of 1,2-hexanediol, 1,2-octanediol, 1,2-decanediol, 1,2-dodecanediol and mixtures thereof, more preferably selected from the group consisting of 1,2-octanediol, 1,2-decanediol, 1,2-dodecanediol and mixtures thereof, and most preferably 1,2-decanediol.

3. The 1,2-alkanediol having 6 to 16 carbon atoms per molecule is used in a form selected from the following: 1,2-decanediol available from Symrise under the trade name SymClariol; a mixture of 1,2-hexanediol and 1,2-octanediol available from Symrise under the trade name SymDiol 68; a mixture of 1,2-hexanediol, 1,2-octanediol and troporone available from Symrise under the trade name SymDiol 68T; a mixture of 1,2-octanediol, 1,2-hexanediol and methylbenzyl alcohol available from Symrise under the trade name SymTriol; a mixture of phenoxyethanol, 1,2-decanediol and 1,2-hexanediol available from Symrise under the trade name SymOcide PS; and mixtures thereof. Preferably, the 1,2-alkanediol having 6 to 16 carbon atoms per molecule is used in a form selected from the following: 1,2-decanediol available from Symrise under the trade name SymClariol, phenoxyethanol available from Symrise under the trade name SymOcide PS, a mixture of 1,2-decanediol and 1,2-hexanediol, and mixtures thereof; More preferably, the 1,2-alkanediol having 6 to 16 carbon atoms per molecule is used in the form of 1,2-decanediol available from SymRise under the trade name SymClariol. The composition according to feature 1.

4. The composition according to claim 1, wherein the hydrolyzed yeast protein is the substance of CAS number 100684-36-4, which is preferably used in the form of a mixture comprising the hydrolyzed yeast protein, 1,2-pentanediol and 1,3-butanediol, the mixture preferably available from BASF under the trade name Relipidium.

5. The composition according to claim 1, wherein the content of the 1,2-alkanediol having 6 to 16 carbon atoms per molecule is 0.01% to 10.0% by weight, preferably 0.02% to 5.0% by weight, and more preferably 0.025% to 2.0% by weight, based on the total weight of the composition.

6. The composition according to claim 1, wherein the content of the hydrolyzed yeast protein is 0.01% to 10.0% by weight, preferably 0.02% to 5.0% by weight, and more preferably 0.03% to 1.0% by weight, based on the total weight of the composition.

7. The composition according to claim 1, wherein the 1,2-alkanediol having 6 to 16 carbon atoms per molecule is used in the form of 1,2-decanediol under the trade name SymClariol, and hydrolyzed yeast protein is used in the form of Relipidium, preferably the content of SymClariol is 0.1% to 2.0% by weight, preferably 0.3% to 1.5% by weight, more preferably 0.4% to 1.3% by weight, and / or the content of Relipidium is 0.1% to 1.0% by weight, preferably 0.3% to 0.7% by weight, more preferably 0.4% to 0.6% by weight, based on the total weight of the composition.

8. The composition according to claim 1, further comprising an additive selected from the group consisting of surfactants, hair humectants, thickeners, preservatives, fragrances, pH adjusters, and / or skin humectants.

9. The composition according to claim 1, which is a hair care, hair styling and / or hair coloring agent and / or scalp care agent, such as a shampoo, hair conditioner, hair styling agent, hair coloring agent, scalp serum and / or scalp spray.

10. A method for improving scalp health, comprising applying a composition according to any one of claims 1 to 9 to the scalp and / or hair.

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